ライフサイエンスコーパス: pentyl

1 o the silica surface from C1 (methyl) to C5 (pentyl).

2 on of cyclohexyl, cycloheptyl, cyclooctyl, 1-pentyl, 1-hexyl, and 1-heptyl substrates, approaching >9

3 m the aliphatic C-H bonds of a series of 1-Z-pentyl, 1-Z-propyl, and Z-cyclohexyl derivatives and of

4 For example, 12-pentyl-1, 12-dicarba-closo-dodecaborane-1-carboxylic aci

5 entricular M40 with intraperitoneal 3-(3-S-n-pentyl-1,2,5-thiadiazol-4-yl)-1,2,5, 6-tetrahydro-1-meth

6 (MPVBC) and (trans,trans)-4-fluorophenyl 4'-pentyl-[1,1'-bi(cyclohexane)]-4-carboxylate (FPeBC) were

7 , and the best-in-class compound, 4-methyl-1-pentyl-1H-benzo[d]imidazol-2-amine, was found to be a pu

8 or 5-chloro-N-(4-(dimethylamino)phenethyl)-3-pentyl-1H-indole-2-carboxamide (11j) was identified.

9 synthesized using (19)F-labeled 2-(5-fluoro-pentyl)-2-methyl malonic acid ((19)F-FPMA) as the labeli

10 dolisation products, 2-butyl-2-octenal and 2-pentyl-2-nonenal, were detected from the interactions be

11 ,6S)-2, 6-dimethyltetrahydro-1(2H)-pyridinyl]pentyl]-2-phenyl-2H-1, 4-benzoxazin-3(4H)-one (1a) as an

12 nalogous dyads based on a zinc 5,10,15-tri(n-pentyl)-20-phenylporphyrin donor show that, for a given

13 ly linked, fixed-distance zinc 5,10,15-tri-n-pentyl-20-phenylporphyrin-NMI-Fe(2)S(2)(CO)(6) donor-acc

14 eries include 5-methoxy-3-(2-methylbenzyl)-7-pentyl-2H-chromen-2-one (19a, PSB-SB-1201), a selective

15 0.022 muM), 5-methoxy-3-(2-methoxybenzyl)-7-pentyl-2H-chromen-2-one (21a, PSB-SB-1202), a dual CB(1)

16 The Deltahda-2 overproduced the VOC 6-pentyl-2H-pyran-2-one (6-PP), which resulted in enhanced

17 t of coconut and dried figs as 5,6-dihydro-6-pentyl-2H-pyran-2-one (C10 massoia lactone).

18 The new ET primers have 3-(epsilon-carboxy-pentyl)-3'ethyl-5,5'-dimethyloxacarbocyanine (CYA; epsil

19 ate, cyclooctyl-4-nitrobenzenesulfonamide, 1-pentyl-3,5-dinitrobenzoate, 1-hexyl-3,5-dinitrobenzoate,

20 The 1-pentyl-3-benzoylindole is characterized by the strong in

21 The base peak at m/z 214 in the 1-n-pentyl-3-benzoylindole represents the M-77 cation fragme

22 ,6S)-2, 6-dimethyltetrahydro-1(2H)-pyridinyl]pentyl]-3-oxo-3,4-dihydro-2H- 1,4-benzoxazin-2-yl)-1-ben

23 3-[4-[5-((2S,6R)-2,6-dimethylpiperidin-1-yl)pentyl]-3-oxo-3,4-dihydroquino xolin-2-yl]benzamidine (3

24 Pentyl 4-(N-doxazolidinylcarbonyloxymethyl)phenylcarbama

25 derivative N-(piperidin-1-yl)-5-phenyl-1-(n-pentyl)-4-methyl-1H-pyrazole-3-carboxamid e (AM263).

26 and dynamics of two 40-nm thick films of 4-n-pentyl-4'-cyanobiphenyl (5CB), a nematic liquid crystal,

27 l interface of a nematic material, namely, 4-pentyl-4'-cyanobiphenyl (5CB).

28 for the case of the liquid crystalline oil 4-pentyl-4'-cyanobiphenyl (5CB).

29 entation of a liquid-crystalline film of 4-n-pentyl-4'-cyanobiphenyl was conducted in a new experimen

30 structure calculations to predict that 4'-n-pentyl-4-biphenylcarbonitrile (5CB), a room temperature

31 BCA (0.005 mol %) was doped into an LC (4'-n-pentyl-4-biphenylcarbonitrile).

32 ing energies of benzonitrile, a model for 4'-pentyl-4-biphenylcarbonitrile, and dimethyl methylphosph

33 morphous film of 5,11-bis(3-methoxyphenyl)-6-pentyl-5,11-dihydroindolo[3,2-b]carbazole exceed 10(-3)

34 lly related to cannabinol (6,6,9-trimethyl-3-pentyl-6 H-benzo[ c]chromen-1-ol), a natural constituent

35 analogous sensitivity to the corresponding 1-pentyl-7-aminophenoxazin-3-one substrate 1 used commerci

36 fluorescence responses to the DmOr47a ligand pentyl acetate that were recovered 12 h after rehydratio

37 e ligand, 2,4-bis(2,6-diisopropylphenylimido)pentyl; Ad = 1-adamantyl).

38 5 with allyl, cyclopropylmethyl, propyl, or pentyl alcohol catalyzed by K(2)CO(3) afforded O(6)-alky

39 iables (14 compounds), including lactones (6-pentyl-alpha-pyrone, gamma-decalactone, gamma-dodecalact

40 opentyl amidine substituents and DB226 has 3-pentyl amidines.

41 und to carrier proteins via the reducing end pentyl amine linker, to explore their antigenic and immu

42 enient access to chiral alpha-substituted (3-pentyl)amines.

43 o-1-[[4-(4-pyridinyl)-1-piperazinyl]carbonyl]pentyl]amino]-1-[ (3,5-dibromo-4-hydroxyphenyl)methyl]-2

44 o-l-[[4-(4-pyridinyl)-l-piperazinyl]carbonyl]pentyl]amino]-1-[(3,5-d ibromo-4-hydroxyphenyl)methyl]-2

45 ipophilic) and 3-fold more potent than the 1-pentyl analog (less lipophilic), indicating that, in add

46 With 1-pentyl and 1-propyl derivatives, alpha-CH2 activation to

47 -A 2B 2- or cis-A 2BC-porphyrins wherein A = pentyl and B/C = pyridyl ( o-, m-, p-).

48 R)H, where R = methyl, ethyl, propyl, butyl, pentyl, and hexyl, to generate RH and Tp'Rh(L)(C(6)D(5))

49 ing substituents (methyl, ethyl, n-propyl, n-pentyl, and phenyl) at the C-1 position of the cocaine t

50 xylate anion does not afford 1-bicyclo[1.1.1]pentyl anion as previously assumed.

51 A 1-bicyclo[1.1.1]pentyl anion was prepared nevertheless via the fluoride-

52 , or five methylene units (propyl, butyl, or pentyl) at C-5 were prepared and tested as reporter prob

53 st method for the synthesis of bicyclo[1.1.1]pentyl (BCP) alkyl ethers from alcohols.

54 Bicyclo[2.1.0]pentyl (BCP) ketones, less strained than BCB ketones, ar

55 ely mild and harsh detergents 5-cyclohexyl-1-pentyl-beta-D-maltoside and n-octyl-beta-D-glucopyranosi

56 biphenyl (5CB) and 4'-(3,4-difluor-phenyl)-4-pentyl-bicylohexyl (5CF) molecules partitioning into a d

57 In this system, 4-cyano-4'-pentyl biphenyl (5CB) was doped with a sulfur- and nitro

58 in the nematic liquid crystal 4-cyano-4'-(n-pentyl)biphenyl (5CB) at cryogenic temperatures results

59 ngeners of pentamidine in which the flexible pentyl bridge of pentamidine was replaced by trans-1,2-b

60 ve study of the electron-induced reaction of pentyl bromide (PeBr) and phenyl bromide (PhBr) on Cu(11

61 Simple butyl and pentyl, but not ethyl, carbamate prodrugs inhibited the

62 yl-butyl-carbamate (34) and 2-ethyl-3-methyl-pentyl-carbamate (38) also exhibited potent activity in

63 form [(PNP)Ti(eta(2)-H2C horizontal lineCH(n)Pentyl)(CH2(t)Bu)] (6) and [(PNP)Ti(eta(2)-H2C horizonta

64 changing the length and branching of the end pentyl chain (C5H11) of anandamide (AN), various analogs

65 Like the THCs, the branching of the end pentyl chain in AN (1e-h) increased potency both in in v

66 It was shown that the SAR of the end pentyl chain in AN is very similar to that of THCs.

67 The pentyl chain on THC 3 and its precursors were replaced w

68 f the methyl group than the methylene of the pentyl chain, in excellent agreement with the previous e

69 ic activators of PKCepsilon, such as 8-(2-(2-pentyl-cyclopropylmethyl)-cyclopropyl)-octanoic acid met

70 cond group consists of alpha-butyl and alpha-pentyl dibenzyl ketones that yield equimolar amounts of

71 d enol ether chain with a maximum ee for the pentyl enol ether.

72 entenes occurs at a slower rate and leads to pentyl ester covalently bound to the surface.

73 ne, 2-nonanone, 1-nonen-3-one, 1-pentanol, 2-pentyl furan, 2-isopropyl-3-methoxypyrazine, 2,5-dimethy

74 germination, microwaving, and fermentation.2-pentyl furan, benzyl alcohol, benzaldehyde, 1-octen-3-ol

75 eptanal, benzeneacetaldehyde, nonanal, and 2-pentyl furan, which contributed to the characteristic ar

76 dienal, 3-methyl-1-butanol, 1-hexanol, and 2-pentyl-furan, were employed to quantify beany flavor for

77 e(2)NN](-) = 2,4-bis(2,6-dimethylphenylimido)pentyl} gives {[Me(2)NN]Ni}(2)(mu-eta(2):eta(2)-ONAr) (1

78 ompared to its tert-butyl analogue, the tert-pentyl group has been found to improve enantioselectivit

79 In particular, the tert-pentyl group of this ligand was systematically replaced

80 a derivative of this analogue lacking the n-pentyl group was produced, consistent with a RedG cataly

81 the p-anisyl group of 1 was replaced by an n-pentyl group, the resultant antagonist 3 exhibited subst

82 tert-Pentyl groups are recognized to be highly effective ster

83 ed orientations of its phosphonic acid and 3-pentyl groups in the NA active site as inferred from the

84 rent from that of a porphyrin bearing linear pentyl groups.

85 enylethyne linker and bear swallowtail (or n-pentyl) groups at the nonlinking meso positions.

86 e labile hydrocarbon in Tp'Rh(CNneopentyl)(n-pentyl)H or Tp'Rh(CNneopentyl)(CH3)H.

87 The synthetic compounds contained pentyl, hexyl, or hexanoyl and octyl lipid chains at the

88 hyldesferrithiocin, N-[5-(acetylhydroxyamino)pentyl]hydroxamate (3); desmethyldesferrithiocin, N-benz

89 ro-3-(1'-2"-R-hydroxy-3'N-(5-amino-1-carboxy pentyl)iminodiacetic acid)propyl ether (DHGN).

90 -ethyl) or potent opioid agonist activity (N-pentyl) in morphinan-like ligands which interact with th

91 or four alkyl groups (ethyl, propyl, butyl, pentyl), in which case microwave irradiation was used fo

92 ed by FTIR spectroscopy for methyl through n-pentyl isocyanide bound to a series of 20 different dist

93 Dendrimers constituted with n-pentyl linker were found to afford higher solubilities o

94 haride units attached to a hydrophobic amino-pentyl linker, a construct not expected to assemble into

95 [3H-4,5-pentyl]MNAN and [3H-2,3-pentyl]-MNAN were synthesized, p

96 [3H-4,5-pentyl]MNAN and [3H-2,3-pentyl]-MNAN were synthesized, purified, and incubated w

97 rate the strategic coupling of bicyclo[1.1.1]pentyl moieties with sulfoximines to achieve a synergist

98 connect the branch junctures from ethyl to n-pentyl moiety (C(2)G3-C(5)G3).

99 In alpha1L232Cbeta3gamma2L receptors, only pentyl-MTS and hexyl-MTS induced persistent effects that

100 d for modifications with ethyl-MTS through n-pentyl-MTS, with unambiguous cut-on and cut-off.

101 4S)-[4-amino-5-[2-(2-aminoethyl)phenylamino]-pentyl]-N'-nitroguanidine (17) (K(i) = 50 nM), which als

102 itors, (4S)-N-{4-amino-5-[(2-aminoethylamino]pentyl}-N'-nitroguanidine (1) and 4-N-(Nomega-nitro-l-ar

103 sq)2 (3, X = Cl, Br, I; disq- = N,N'-bis(neo-pentyl)-ortho-diiminosemiquinonate) in which each redox-

104 omplex, [Zr(pda)2]n (1, pda2- = N,N'-bis(neo-pentyl)-ortho-phenylenediamide, n = 1 or 2), prepared by

105 uoro-2-(1-methyl-4-piperidyl)phenyl]-2-oxo-N-pentyl-oxazole-3-carboxamide 32b as a potent AC inhibito

106 ers contain one or two thermolabile, 4-oxo-1-pentyl (OXP) phosphotriester (PTE) modification groups a

107 ydroxy-4- methyl-1-oxo-2-[(1-oxopropyl)amino]pentyl]oxy]-L-leucyl-N,O-dimethyl-,(7-->1)-lac tone (9CI

108 Furthermore, one CAPH, Pentyl-P14 exhibited excellent antibacterial activity ag

109 Pentyl PABC-Doxaz (PPD) is a Doxaz carbamate prodrug tha

110 Pentyl PABC-Doxaz (PPD) is a prodrug of Doxaz that is ac

111 Moreover, the most potent n-pentyl PAIB-SOs were significantly more stable toward ro

112 h one of three acceptors: achiral N,N-bis(3'-pentyl)perylene-(3,4:9,10)-bis(dicarboximide) and two en

113 ne (Cor) or pyrene (Pyr) and A is N,N-bis(3'-pentyl)-perylene-3,4:9,10-bis(dicarboximide) (C(5)PDI) o

114 [(6-(18)F-fluoro-pyridine-3-carbonyl)-amino]-pentyl) PET/CT.

115 R = tBu, Ar = TCHP 2; R = Et, Ar = 2,6-di(3-pentyl)phenyl (Dipep) 3) have been synthesized.

116 Tris(bicyclo[1.1.1]pentyl)phosphine can be prepared by radical addition of

117 phenylphosphine gives the bis(bicyclo[1.1.1]pentyl)phosphine derivative PBcp(2)Ph, illustrating the

118 primers with one or two thermolabile 4-oxo-1-pentyl phosphotriester modifications in improving multip

119 butyl phthalate, diisopentyl phthalate, di-n-pentyl phthalate, di-(2-ethylhexyl) phthalate, di-n-octy

120 late, DBP; diisopentyl phthalate, DIPP; di-n-pentyl phthalate, DNPP; dihexyl phthalate, DHP; butyl be

121 sisting of four zinc 5-phenyl-10,15,20-tri(n-pentyl)porphyrins (Z3PN) attached to the 1,7,N,N'-positi

122 ligand design led to the identification of 3-pentyl-quinoline-2-amine as a novel, human TLR8-specific

123 ron affinity of 3-tert-butyl-1-bicyclo[1.1.1]pentyl radical (14.8 plus minus 3.2 kcal/mol) was measur

124 intensity at 1681 cm(-1) in the 1-benzoyl-3-pentyl regioisomer.

125 ionships regarding the highly functionalized pentyl side chain attached at C-3 of mithramycin (MTM),

126 studies evidence that PAIB-SOs bearing an n-pentyl side chain exhibit antiproliferative activity in

127 carrying an alkyne instead of the natural n-pentyl side chain has been developed.

128 of the MTM biosynthesis, a keto group of the pentyl side chain is reduced to a secondary alcohol, and

129 to bind to the DNA, alteration of the MTM 3-pentyl side chain led to a compound (mithramycin SK) wit

130 9-THC, (3) the five terminal carbons and the pentyl side chain of delta9-THC, and (4) the polyolefin

131 direct desaturation of the C1-C2 bond in the pentyl side chain of jasmolone to produce pyrethrolone.

132 r cleavage reactions of the initially formed pentyl side chain with a reactive beta-dicarbonyl functi

133 g of premithramycin B (PMB), creating the C3 pentyl side chain, strictly followed by reduction of the

134 duced a terminal carboxylic acid on a single pentyl side chain.

135 ially, highlighting that the position of the pentyl substituent can be varied while maintaining detec

136 For example, the 2-pentyl substituted aminophenoxazin-3-one 22b performed w

137 se inhibitors that comprise rare N-hydroxy-2-pentyl-succinamic acid warheads.

138 nonin and matlystatin feature an N-hydroxy-2-pentyl-succinamyl (HPS) chemophore that facilitates meta

139 allography to show that it features a rare 2-pentyl-succinyl chemophore.

140 lane via synthesis of N,N'-bis(bicyclo[1.1.1]pentyl)sulfamide and azoxybicyclo[1.1.1]pentane.

141 n, there is an increasing preference for the pentyl tail of Delta(8)-THC to bend toward the tricyclic

142 s possessing bulky N-substituents (e.g., neo-pentyl, tert-butyl, etc.) were stable in the solid-state

143 activity occurring for the butyl (TLR-7) and pentyl (TLR-8) derivatives.

144 e concerted rearrangement of a bicyclo[1.1.1]pentyl to a bicyclo[1.1.0]butyl carbocation, initiated b

145 contrast, no enhancement in potency for the pentyl to DMH side chain exchange was seen in the mouse

146 2-(3-(1-carboxy-5-(4-(211)At-astatobenzamido)pentyl)ureido)-pentanedioic acid ((211)At- 6: ) was synt

147 ((S)-1-carboxy-5-((4-(123)I-iodobenzyl)amino)pentyl)ureido)pentanedioic acid, (123)I-MIP-1072, target

148 (S)-2-(3-((S)-1-carboxy-5-(4-iodobenzylamino)pentyl)ureido)pentanedioic acid, and MIP-1095, (S)-2-(3-

149 2-(3-((S)-1carboxy-5-(3-(4-iodophenyl)ureido)pentyl)ureido)pentanedioic acid, were selected for furth

150 [(6-(18)F-fluoro-pyridine-3-carbonyl)-amino]-pentyl)-ureido)-pentanedioic acid ((18)F-DCFPyL), a seco

151 [(6-(18)F-fluoro-pyridine-3-carbonyl)-amino]-pentyl)-ureido)-pentanedioic acid PET/CT.

152 (6-[(18)F]fluoro-pyridine-3-carbonyl)-amino]-pentyl)-ureido)-pentanedioic acid), or (18)F-JK-PSMA-7 (

153 [(6-(18)F-fluoro-pyridine-3-carbonyl)-amino]-pentyl)-ureido)-pentanedioic acid], a second-generation

154 rsatile intermediate 2-[3-(5-amino-1-carboxy-pentyl)-ureido]-pentanedioic acid (Lys-C(O)-Glu), which

155 [(5-[(125)I]iodo-pyridine-3-carbonyl)-amino]-pentyl]-ureido)-pe ntanedioic acid ([(125)I]8) in 65-80%

156 [3-[1-carboxy-5-(4-(125)I-iodo-benzoylamino)-pentyl]-ureido]-pentanedioic acid ((125)I-DCIBzL) was sy

157 3-[1-carboxy-5-(4-[(125)I]iodo-benzoylamino)-pentyl]-ureido]-pentanedioic acid ([(125)I]3), 2-[3-[1-c

158 -[1-carboxy-5-(4-[(18)F]fluoro-benzoylamino)-pentyl]-ureido]-pentanedioic acid ([(18)F]6), and 2-(3-[

159 [(6-(18)F-fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-p entanedioic acid) and more recently (1

160 oxy-5-[(6-fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentaned ioic acid (DCFPyL), PSMA-617, P

161 -[(6-[18F]fluoro-pyridine 3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid ((18)F-DCFPyL) may imp

162 (6-[(18)F]fluoro-pyridine 3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid ((18)F-DCFPyL) PET aft

163 (6-[(18)F]fluoro-pyridine 3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid ((18)F-DCFPyL) PET in

164 -[(6-[18F]fluoro-pyridine 3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid ((18)F-DCFPyL) were hi

165 [(6-(18)F-fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid ((18)F-DCFPyL) were pe

166 (6-[(18)F]fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid (DCFPyL) for targeting

167 (6-[(18)F]fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid (DCFPyL) had a high bi

168 -[(6-(18)F-fluoropyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid) is a promising PET ra

169 [(6-(18)F-fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid) PET/CT in patients wi

170 [(6-(18)F-fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid), a prostate-specific

171 9 emu g(-1)), which can effectively catalyze pentyl valerate esterification and be easily separated b