ライフサイエンスコーパス: penumbra

1 f recruited neurons and a surrounding 'ictal penumbra'.

2 mbral pattern (large core or small or absent penumbra).

3 f salvageable ischemic brain tissue (ie, the penumbra).

4 core seizure territory from the surrounding penumbra.

5 an10, Tspan14, Tspan15, Tspan17, and Tspan33/Penumbra.

6 el that included the volume of non-infarcted penumbra.

7 damage to the surrounding area known as the penumbra.

8 ked beta-catenin degradation in the ischemic penumbra.

9 ng and neuronal excitotoxicity in the injury penumbra.

10 a defect that is reversed by reexpression of Penumbra.

11 r in the delayed cell losses of the ischemic penumbra.

12 ion and apoptotic cell death in the ischemic penumbra.

13 rization and cell death, particularly in the penumbra.

14 ution of irreversible damage in the ischemic penumbra.

15 the temporal and spatial progression of the penumbra.

16 in diabetic rats in both ischemic focus and penumbra.

17 a 67.9% (p<0.05) increase in APP mRNA in the penumbra.

18 xia that mimics many features of an ischemic penumbra.

19 chemic region, and to a lesser extent in the penumbra.

20 ate and GABA observed in the focal ischaemic penumbra.

21 bition of glutamate release in the ischaemic penumbra.

22 rstanding the pathophysiology of an ischemic penumbra.

23 th potentially increased significance of the penumbra.

24 bility by maintaining blood flow to ischemic penumbra.

25 na; Hasten Biopharmaceutic; Genesis Medtech; Penumbra.

26 es and identifying patients with salvageable penumbra.

27 creases in extracellular potassium levels in penumbra.

28 osis), could better reproduce aspects of the penumbra.

29 abnormalities serves as an indicator of the penumbra.

30 n may represent resolution of the reversible penumbra.

31 and their continued accumulation within the penumbra.

32 proposed as a metabolic marker of ischaemic penumbra.

33 ard afforded due to sharp lateral and distal penumbras.

34 rated peak NP accumulation within the injury penumbra 1 h post-injury.

35 eas temperature was highest in the potential penumbra (37.7 versus 37.3 degrees C in lesion core, P <

36 igger spreading depolarizations in ischaemic penumbra (4-fold increase in spreading depolarization oc

37 vely) was much smaller than that of salvaged penumbra (59.3 and 93 ml, respectively), it was substant

38 k of a simple in vitro model of the ischemic penumbra, a clinically relevant region of stroke-afflict

39 ls) of reperfusion catheters manufactured by Penumbra, a US-based medical device company, illustrates

40 he ischemic core and diffuse to the ischemic penumbra, activating microglia and promoting proinflamma

41 astrocyte signalling through the 'mechanical penumbra' affects the activity of neural circuits distan

42 inistered during periods of the inflammatory penumbra after active lesion formation, and was shown to

43 Thus, increasing the energy imbalance in the penumbra after multiple SDs may hasten the deterioration

44 , California) (40%) and the Penumbra System (Penumbra, Alameda, California) (9%), represented a large

45 Hence, strategies to keep the penumbra alive until reperfusion occurs are needed.

46 ral O2 pressure and by such may maintain the penumbra alive until reperfusion.

47 ng reduction of the GAG chains in the lesion penumbra and allowed axons to regenerate around the core

48 ade of collateral circulation, the ischaemic penumbra and clinical functional outcome.

49 d reduced in-plane vessel length between the penumbra and contralateral gray matter (-16.7% vs. -20.5

50 whole-brain coverage to measure the ischemic penumbra and core and to compare its performance to that

51 processing with different programs measuring penumbra and core areas reveal poor correlation.

52 g with one program developed for identifying penumbra and core areas show a strong correlation.

53 wo different packages designed for measuring penumbra and core areas.

54 of their ability to consistently define the penumbra and core in an ischemic area.

55 volume at CT perfusion was compared with the penumbra and core reference values at magnetic resonance

56 in ischemic volume delineated by the optimal penumbra and core threshold was determined as the brain

57 Results CT perfusion at penumbra and core thresholds resulted in the least volum

58 esonance (MR) imaging to derive CT perfusion penumbra and core thresholds.

59 btained were compared to the distribution of penumbra and core within the ischaemic area received fro

60 iently increased at 5 h in both the ischemic penumbra and core, and the total protein level of beta-c

61 iability in dividing the ischaemic zone into penumbra and core.

62 maximize the dose rate while minimizing beam penumbra and cross-channel leakage.

63 re measured in contralateral (non-ischemic), penumbra and densely ischemic brain regions.

64 An overlap between non-infarcted penumbra and functional magnetic resonance imaging clust

65 TBI penumbra and hippocampus had higher cellular proliferati

66 of different perfusion CT thresholds for the penumbra and infarct core with each postprocessing metho

67 as shown that there is marked variability in penumbra and infarct prediction among various deconvolut

68 BH-treated penumbra and its identical lobe showed reduced liver fib

69 ith significant fewer apoptotic cells in the penumbra and less BBB disruption; PHD3-/- mice had impai

70 Lymphocytes infiltrate the stroke core and penumbra and often exacerbate cellular injury.

71 Lesion core, penumbra and peri-penumbra, and normal-appearing brain,

72 c rats enhanced angiogenesis in the ischemic penumbra and significantly improved neurological recover

73 induced by IS accurately mimics the in vivo penumbra and thus whether our model system is suitable f

74 mbining clinicoradiological information (ie, penumbra and vessel status), anticoagulant activity and

75 Each tumor, its surrounding penumbra, and bone marrow from the L3-L5 vertebral bodie

76 adiomic features of the primary tumor, tumor penumbra, and bone marrow identifies lung cancer disease

77 xture features from the primary tumor, tumor penumbra, and bone marrow predicts disease-free survival

78 target of acute stroke therapy, the ischemic penumbra, and clinically available imaging modalities su

79 is this boundary zone that comprises the new penumbra, and future investigations should dissect where

80 Lesion core, penumbra and peri-penumbra, and normal-appearing brain, ischaemic brain vo

81 esonance imaging responses and non-infarcted penumbra, and tested the hypothesis that the former do t

82 f LRP in neurons within the area of ischemic penumbra, and this effect was attenuated in mice treated

83 identify a small ischemic core and ischemic penumbra, and this information will contribute increasin

84 idence of cortical ischemia with salvageable penumbra, and were ineligible for reperfusion therapies.

85 nge between these thresholds was termed the "penumbra," and restitution of flow above the functional

86 Moreover, the ischemic penumbra APN levels increased and peaked in T1DM-2W mice

87 perfusion 'mismatch' being representative of penumbra appears to be an oversimplification.

88 Taken together, our findings suggest that penumbras are pertinent for understanding variation in t

89 reduced VT recurrence and increased unipolar penumbra area predicted cardiac death.

90 concentrations of reactive aldehydes in the penumbra area, we investigated if the hydrazine function

91 low voltage areas, unipolar low voltage and penumbra areas) and morphology characteristics (presence

92 However, although the non-infarcted penumbra as a whole was affected by selective neuronal l

93 motor and somatosensory areas of the injury penumbra as compared to the parietal association and vis

94 Penumbra as defined by (15) O-PET cerebral blood flow (C

95 The same validation based on penumbra as defined by quantitative (15) O-PET CBF was p

96 geted photothrombosis produced a more graded penumbra at 48 and 120 h.

97 Following ischemic stroke, the penumbra, at-risk neural tissue surrounding the core inf

98 e than 2 seconds most accurately defined the penumbra (AUC = 0.86, P = .046, mean volume difference b

99 teral cerebral blood flow (CBF) to ischaemic penumbra because it can cause vasoconstriction.

100 emerged that focus not only on the ischemic penumbra but also on the infarct core.

101 ed preferentially in neurons in the ischemic penumbra but not in the ischemic core or in brain region

102 the tissue putrescine level was found in the penumbra but there was no difference in the putrescine l

103 ulated angiogenesis in the striatal ischemic penumbra, but not the dentate gyrus.

104 reased apoptotic cell counts in the ischemic penumbra by more than 50%.

105 of irreversible infarction as well as of the penumbra by the MRI modalities.

106 tion of erythropoiesis, we identified murine Penumbra cDNA from a multipotent hematopoietic cell line

107 wing image coregistration, the non-infarcted penumbra comprised all acutely ischaemic voxels (identif

108 Human and murine Penumbras contain 283 amino acids and are 97% identical.

109 rvation of these glial cells in the ischemic penumbra corresponded with a markedly reduced area of in

110 Selective neuronal loss (SNL) in the rescued penumbra could account for suboptimal clinical recovery

111 rombectomy (baseline mRS 0-1) and had viable penumbra (CT perfusion or Alberta Stroke Program Early C

112 The "salvaged penumbra" defined by the area of mismatch between the fi

113 To study the effects of Penumbra deletions, we created a knockout mouse model by

114 netic resonance imaging (MRI) mismatch-based penumbra detection against full quantitative positron em

115 mography ((15) O-PET), the gold standard for penumbra detection in acute ischemic stroke.

116 Tmax >5.6 seconds-based penumbra detection is reliable to guide treatment decisi

117 Clinical evidence for Penumbra devices was generated from nonrandomized, singl

118 severe, cerebral blood flow in the ischemic penumbra during reperfusion was reduced, and NMDA neurot

119 ggest that stroke victims with a significant penumbra estimated by the diffusion/perfusion mismatch o

120 to improve cerebal blood flow to reduce the penumbra following stroke.

121 Subsequently, we identified the human PENUMBRA from a bone marrow cDNA library.

122 The optimal threshold to discriminate penumbra from oligemia was Tmax >5.6 seconds with a sens

123 CT perfusion allowed differentiation of the penumbra from the ischemic core in patients with acute i

124 The human PENUMBRA gene is mapped to chromosome 7q32, a hot spot f

125 Tmax (AUC 0.9) was the best estimator of the penumbra (group A), CBF relative to the contralateral he

126 f 2.6 +/- 2.1 days, the estimation regarding penumbra (group A, ATI: r = 0.63/0.69, ATS: r = 0.64) an

127 These findings indicate that Penumbra has a positive function in erythropoiesis and i

128 therapeutic approaches aiming to rescue the penumbra have failed, likely due to unspecific targeting

129 in the scar, increased vessel density in the penumbra, higher tumor necrosis factor alpha plasma leve

130 ing depolarizations in an electrophysiologic penumbra (i.e. isoelectric cortex with no spontaneous ac

131 ntracerebally transplanted into the ischemic penumbra immediately (within 1 h) after stroke surgery.

132 The existence of a penumbra implies that therapeutic salvage is theoretical

133 f occludin serine 490 (S490) in the ischemic penumbra in a tPA-dependent manner, as tPA-/- mice were

134 ies that selectively target the inflammatory penumbra in experimental autoimmune encephalomyelitis le

135 stantial percentage of patients have notable penumbra in extended time windows; the findings of this

136 stigated genetic determinants of the size of penumbra in mice subjected to middle cerebral artery occ

137 ies, continues to be advanced by imaging the penumbra in novel ways.

138 Given the key role of the ischaemic penumbra in stroke pathophysiology, we hypothesised that

139 ut potentially salvageable tissue (i.e., the penumbra) in stroke patients can be achieved.

140 l role of PGs, and particularly those in the penumbra, in causing regeneration failure in the adult s

141 aluated the Indigo CAT RX Aspiration System (Penumbra Inc, Alameda CA) for sustained mechanical aspir

142 The ischemic penumbra includes not only the region of diffusion/perfu

143 osis/autophagy characteristic of the in vivo penumbra, including: (1) short-term elevation of [ATP] f

144 After an initial decrease, blood flow in the penumbra increased during the first 10 min after injury,

145 lude that our in vitro model of the ischemic penumbra induces autophagy and apoptosis in cultured neu

146 Stroke penumbra injury caused by excess glutamate is an importa

147 fts and cause progressive recruitment of the penumbra into the core infarct.

148 ause vasoconstriction and recruitment of the penumbra into the ischemic core in the critical first ho

149 levation in diffusion lesion core, potential penumbra, ipsilateral and contralateral normal brain and

150 Penumbra is a new member of the tetraspanin superfamily

151 keeping with the hypothesis that the rescued penumbra is affected by SNL.

152 The penumbra is an area of brain tissue that is damaged but

153 er, we find evidence that entering a group's penumbra is associated with a change in attitude on grou

154 However, whether the non-infarcted penumbra is capable of neuronal activation, and how sele

155 at 1-3 months after stroke the non-infarcted penumbra is capable of neuronal activation, consistent w

156 Imaging the penumbra is essential, not only to identify patients who

157 Penumbra is targeted to the cell surface and forms disul

158 The defining feature of the 'ictal penumbra' is the contrast between the large amplitude EE

159 produce a square-shaped lesion surrounding a penumbra-like "area at risk" in middle cerebral artery t

160 uorescent protein-expressing neurons in this penumbra-like area at risk revealed that SDs were tempor

161 However, the rescued penumbra may be affected by selective neuronal loss, as

162 that increase in BVR expression in ischemic penumbra may present a cellular defense mechanism agains

163 latory history and clinical evidence for the Penumbra medical devices were analyzed through a qualita

164 Penumbra(-/-) mice develop massive splenomegaly, basophi

165 ischaemic core volume (ICV>=110 mL) or core-penumbra mismatch ratio (MMR<=1.4) thresholds resulted i

166 X, was established from the bone marrow of a Penumbra(-/-) mouse.

167 Bland-Altman plots indicated that these penumbra-nulled IR images provided more accurate predict

168 btained from tp3 T2-weighted images and the "penumbra" obtained from the tp1 perfusion-weighted image

169 in significantly reduced CSPG levels in the penumbra of 49% at 14 and 40% at 28 days post-injury com

170 cumulation of Abeta deposits decrease in the penumbra of CCI months after TBI.

171 Laser-speckle imaging showed that the penumbra of cerebral ischaemia was narrower in the activ

172 amples were harvested from ischemic core and penumbra of cortices at one hour and twenty-four hours f

173 accumulates within neuronal processes in the penumbra of hypoxic damage in adult brain, and within ne

174 lation of PrP(C) in neuronal soma within the penumbra of ischemic lesions.

175 e or male human iESCs were injected into the penumbra of ischemic myocardial tissue of female mice or

176 with local metabolic stress, similar to the penumbra of ischemic/hypoxic states.

177 To assess whether quantifying this penumbra of lung at risk would predict FEV1 decline.

178 rmine whether new emphysema arises from this penumbra of mechanically affected lung (MAL) or from sma

179 in the form of neurofibrillary tangles or a penumbra of neurites surrounding amyloid cores also dist

180 n with promoted angiogenesis in the ischemic penumbra of rat brains after treadmill exercise.

181 xercise-induced angiogenesis in the ischemic penumbra of rat brains, and whether caveolin-1 changes c

182 nes were then transplanted into the striatal penumbra of rats, 1 h following middle cerebral artery o

183 ty have largely focused on activation in the penumbra of the lesion or in contralesional, homotopic r

184 Such recovery is based on the visible penumbra of the opaque object having a linear dependence

185 e, Bif-1 expression was downregulated in the penumbra of wild-type mice.

186 polyubiquitinated proteins were increased in penumbra of WT mouse brains but not in KI mouse brains a

187 the largest effect size among patients with penumbras of 120 mL or more (adjusted common odds ratio

188 the smallest effect size among patients with penumbras of 72 mL or less (ACOR, 0.49 [95% CI, 0.22-1.0

189 us to learn about the characteristics of the penumbras of politically relevant groups such as gay peo

190 eals major and systematic differences in the penumbras of various social groups, even ones of similar

191 ularly in the inner infarct border zone (the penumbra), of the bid-deficient brains.

192 ute anterior circulation stroke, presence of penumbra on computed tomography perfusion performed with

193 f they had a small ischemic core and a large penumbra on their baseline CT perfusion.

194 ificantly reduced in the whole non-infarcted penumbra (P < 0.01) but not within the functional magnet

195 ct growth (P = .004) and had higher salvaged penumbra (P = .009) volumes than patients without reperf

196 of maximal injury at 48 h postinjury (injury penumbra) (p<0.001).

197 lesion core (42 versus 26 units in potential penumbra, P < 0.05), whereas temperature was highest in

198 mic core, which gradually expands toward the penumbra, partly as the result of a neuroinflammatory re

199 fusion-weighted imaging lesion) and presumed penumbra (perfusion-diffusion mismatch [threshold = T(ma

200 In the focal ischaemic penumbra, peri-infarct depolarizations have prolonged di

201 The main therapeutic target is the ischemic penumbra, potentially salvageable brain tissue that dies

202 There were 156 bone marrow and 512 tumor and penumbra radiomic features computed from the PET series.

203 The presence of a substantial penumbra ranged from approximately 80% in patients image

204 Penumbra ratio differed significantly by strain (F = 2.7

205 amine the effects of genetic variants on the penumbra ratio, defined as the ratio of the infarct volu

206 We have identified 6 candidate genes for penumbra ratio: Clint1, Nbea, Smtnl2, Rin3, Dclk1, and S

207 e present at elevated levels in the ischemic penumbra region after middle cerebral artery occlusion.

208 eath but not typical apoptosis occurs in the penumbra region and non-ischemic thalamus after cerebral

209 placed into the previously defined ischemic penumbra region and perfused with a salicylate/CSF solut

210 of free radical adduct formation within the penumbra region during cerebral ischemia/reperfusion may

211 radical adduct formation was observed in the penumbra region during ischemia/reperfusion.

212 lial activation state were visualized in the penumbra region of mice before and after ischemia induce

213 ositive cells in the thalamus and the cortex penumbra region represented a hybrid death, featured by

214 c and apoptosis-inducing factor (AIF) in the penumbra region were reduced by NBP.

215 n that tissue putrescine is increased in the penumbra region, an area of incomplete ischemia that is

216 le for monitoring metabolic responses in the penumbra region.

217 p<0.05) including the most affected ischemic penumbra regions (e.g. hippocampus, pallium).

218 rmation was observed in densely ischemic and penumbra regions.

219 -induced injury to synaptic circuitry in the penumbra remain unknown.

220 the therapeutic aim to salvage the ischemic penumbra remains a formidable challenge.

221 gulatory analysis indicated that each of the Penumbra reperfusion catheters was cleared under the 510

222 Traumatic peri-contusional penumbra represents crucial targets for therapeutic inte

223 k ahead as we move into the fourth decade of penumbra research?

224 of 52.9% and 57.0% (p<0.05) in the core and penumbra, respectively.

225 we found increased flow at the periphery, or penumbra (rostral, p < 0.05; caudal, p < 0.01), followin

226 The primary endpoint was percentage of penumbra salvaged (CT perfusion-defined penumbra volume

227 "Penumbra sign" (hyperintense rim on T1W images), diffusi

228 "Penumbra sign" on T1W images was significantly more comm

229 "Penumbra sign" on T1W images, diffusion characteristics,

230 In the penumbra, six genes related to axongenesis (Erbb2); grow

231 ctal discharges in both the seizure core and penumbra (spatial seizure domains defined by multiunit a

232 A key finding was that in the penumbra, spike stereotypy was maintained even during th

233 As expected, salvaged penumbra strongly positively influenced early neurologic

234 Care, Medtronic/Covidien/EV3, Medac/Lamepro, Penumbra, Stryker, and Top Medical.

235 The original concept of the ischaemic penumbra suggested imaging of regional cerebral blood fl

236 rily associated with neurons in the ischemic penumbra, suggesting an important role for PPARgamma in

237 erfusion; however, recent examination of the penumbra suggests a central role for NADPH-oxidase (Nox)

238 newborn neurons are present in the ischemic penumbra surrounding cerebral cortical infarcts, where t

239 spreading depolarizations (SDs) occur in the penumbra surrounding ischemic core.

240 selected to null signal from the peripheral penumbra surrounding the ablation zone (r = 0.939, P < .

241 al, Mountain View, California) (40%) and the Penumbra System (Penumbra, Alameda, California) (9%), re

242 h the MERCI Retriever and 0% to 11% with the Penumbra System) or asymptomatic (13 studies; 28% to 43%

243 o mechanical embolectomy (Merci Retriever or Penumbra System) or receive standard care.

244 the MERCI Retriever and 83% to 100% with the Penumbra System).

245 bone marrow texture features, one tumor with penumbra texture feature, and two penumbra texture featu

246 tumor with penumbra texture feature, and two penumbra texture features (concordance, 0.78; 95% confid

247 ltage beam provides a 5-fold sharper lateral penumbra than a 6-MV x-ray beam.

248 magnitude of the changes was greater in the penumbra than in the normal cortex.

249 on and microvascular patency in the ischemic penumbra that is coordinated by S1P signaling and can be

250 on depolarizing waves (PIDs) in the ischemic penumbra, the territory of salvage.

251 Accurate identification of the ischemic penumbra, the therapeutic target in acute clinical strok

252 We contend that a group's penumbra-the set of individuals who are personally famil

253 ntrating drugs within the compromised BBB of penumbra, thereby ameliorating AIS.

254 lectively dilates arterioles in the ischemic penumbra, thereby increasing collateral blood flow and s

255 n tips dieback from the lesion core into the penumbra they closely associate with NG2+ cells.

256 an be repeatedly investigated to demonstrate penumbra tissue, which can benefit from therapeutic inte

257 ential in the transfer of the concept of the penumbra to clinical stroke and thereby had a great impa

258 e, we utilized a novel in vitro model of the penumbra to examine the free radical profile of ischemic

259 l and ischemic brain, but the ability of the penumbra to recover from the insult is compromised.

260 became upregulated in vessels of the stroke penumbra using a mouse model of reversible middle cerebr

261 e estimate of ischemic core volume (ICV) and penumbra volume (PV) is important in decision-making for

262 rial, there was a direct interaction between penumbra volume and treatment effect, and a trend toward

263 e of penumbra salvaged (CT perfusion-defined penumbra volume at baseline minus CT infarct volume at 2

264 although enrollment of patients with minimal penumbra volume was low.

265 t was analyzed in subgroups of core volumes, penumbra volume, and mismatch ratios using ordinal regre

266 Penumbra volumes significantly modified the association

267 d ischaemic core and potentially salvageable penumbra volumes were associated with functional outcome

268 The smaller penumbra was associated with a lower density of terminal

269 Substantial penumbra was defined as greater than or equal to 15 mL a

270 The concept of the ischemic penumbra was formulated on the basis of animal experimen

271 4 double-positive cells towards the ischemic penumbra was increased in the exercise group.

272 maging activation clusters and non-infarcted penumbra was mapped, and binding potential values then c

273 ts failure to produce a substantial ischemic penumbra weakens its resemblance to human stroke.

274 Cell death in the thalamus and the cortex penumbra were attenuated by delayed administration of th

275 ted tissue, and the eventually non-infarcted penumbra, were determined by performing voxel-wise analy

276 ion size and neuronal damage in the ischemic penumbra when administered six hours post middle cerebra

277 o gives valuable information on the ischemic penumbra which are very important in early diagnosis and

278 RTD; and (iii) prolonged RTD representing a 'penumbra', which slowly succumbs to molecularly governed

279 VT was seen among patients with the smallest penumbras, which warrants further research.

280 t artery-targeted photothrombosis widens the penumbra while maintaining the ability to create localiz

281 central umbra is surrounded by a filamentary penumbra, whose complicated fine structure has only rece

282 ies demonstrate that imaging of the ischemic penumbra with diffusion/perfusion magnetic resonance ima

283 ollows the dynamics of the ischemic core and penumbra with submillimeter spatial and second-scale tem

284 nt of a more severe perfusion deficit in the penumbra within 4 h of MCAO supports the hypothesis that

285 rons surrounding the ischemic core (ischemic penumbra) within 6 hours of occlusion of the middle cere

286 rations should benefit damaged tissue in the penumbra zones and in remote brain regions.