ライフサイエンスコーパス: peptidase

1 nd Astn2 as the endoplasmic reticulum signal peptidase.

2 , followed by cleavage by the inner membrane peptidase.

3 ysis of catalytic specificity of an aspartic peptidase.

4 ase in complex with a self-compartmentalized peptidase.

5 eophilic attack during catalysis of cysteine peptidases.

6 of proteolysis phenomenon exerted by muscle peptidases.

7 -8) is mediated by the activities of several peptidases.

8 biotics that can be hydrolyzed by wastewater peptidases.

9 active fragments by at least three different peptidases.

10 ast proteostasis is governed by a network of peptidases.

11 ficity of dissolved extracellular wastewater peptidases.

12 s an oral reversible inhibitor of dipeptidyl peptidase 1 (DPP-1), an enzyme responsible for the activ

13 Plastidic Type I Signal Peptidase 1 (Plsp1) is an integral thylakoid membrane si

14 akoid integration of Plastidic type I signal peptidase 1 (Plsp1) using in vitro targeting assays.

15 protein 1 (RAD51AP1)-UAF1-ubiquitin-specific peptidase 1 (USP1) trimeric deubiquitinase complex.

16 nonsense mutations in the TPP1 (tripeptidyl peptidase 1), DMD (dystrophin), SMARCAL1 (SWI/SNF-relate

17 heat shock protein 60, Clp protease, and Lon peptidase 1.

18 the mRNA encoding for the ubiquitin-specific peptidase 11 (USP11), a known modulator of TGF-beta sign

19 quitinases, in particular ubiquitin specific peptidase 14 (USP14).

20 Deficiency of ubiquitin-specific peptidase 18 (USP18) is a severe type I interferonopathy

21 diated by upregulation of ubiquitin-specific peptidase 18 (USP18).

22 ate-specific enzyme human kallikrein-related peptidase 2 (hK2; KLK2).

23 xp3 expression, including ubiquitin-specific peptidase 22 (Usp22) and ring finger protein 20 (Rnf20).

24 eaves and inactivates the ubiquitin-specific peptidase 28 (USP28), preventing USP28 from de-ubiquitin

25 Dipeptidyl peptidase 3 (DPP3) is a zinc-dependent hydrolase involve

26 produced via cleavage by kallikrein-related peptidase 3 (KLK3), aka prostate-specific antigen (PSA).

27 s of Campylobacter jejuni, the peptidoglycan peptidase 3 (Pgp3), are reported.

28 d miR-148a suppresses the ubiquitin-specific peptidase 33 (USP33) protein expression levels via bindi

29 have demonstrated CV safety of 3 dipeptidyl peptidase 4 (DPP-4) inhibitors but have included limited

30 tide 1 receptor (GLP-1) agonists, dipeptidyl peptidase 4 (DPP-4) inhibitors, peroxisome proliferator-

31 s such as the tetraspanin CD9 and dipeptidyl peptidase 4 (DPP4) along with multiple endosomal sorting

32 ced levels of the virus receptor, dipeptidyl peptidase 4 (DPP4) and higher basal levels of interferon

33 e coronavirus (MERS-CoV) utilizes dipeptidyl peptidase 4 (DPP4) as an entry receptor.

34 ficient mice receiving background dipeptidyl peptidase 4 (DPP4) inhibitor treatment were characterize

35 e 1 receptor (GLP1R) agonists and dipeptidyl peptidase 4 (DPP4) inhibitors, can also reduce blood pre

36 e-1 (GLP-1) receptor agonists and dipeptidyl peptidase 4 (DPP4) inhibitors, with the risk of Parkinso

37 o the cell surface entry receptor dipeptidyl peptidase 4 (DPP4) occurs via S1(B) We now demonstrate t

38 S-CoV) binds to cellular receptor dipeptidyl peptidase 4 (DPP4) via the spike (S) protein receptor-bi

39 r MERS-CoV has been identified as dipeptidyl peptidase 4 (DPP4), the mouse DPP4 homologue does not al

40 novirus transduction of the human dipeptidyl peptidase 4 (hDPP4) receptor and then analyzed the abili

41 +/+) and heterozygous (+/-) human dipeptidyl peptidase 4 (hDPP4) transgenic mice to study the effect

42 S) glycoprotein to sialosides and dipeptidyl-peptidase 4 (the attachment and entry receptors, respect

43 ulfonylureas, thiazolidinediones, dipeptidyl peptidase 4 [DPP-4] inhibitors, glucagon-like peptide 1

44 e identified as a major source of dipeptidyl peptidase 4 and we also found that skin mast cells and f

45 wo clinically used T2D drugs: the dipeptidyl peptidase 4 inhibitor linagliptin and the sulfonylurea g

46 aking metformin with or without a dipeptidyl peptidase 4 inhibitor.

47 ety of alogliptin, a nonselective dipeptidyl peptidase 4 inhibitor.

48 es, sulfonylurea, glitazones, and dipeptidyl peptidase 4 inhibitors have variable effects on cardiova

49 nd is critical for the actions of dipeptidyl peptidase 4 inhibitors that enhance GLP-1 levels in pati

50 heir efficacy and safety in human dipeptidyl peptidase 4 transgenic (hDPP4 Tg+) mice.

51 Dipeptidyl peptidase 4 was found to be expressed in mast cells in n

52 etry analysis revealed that DPP4 (dipeptidyl peptidase 4) was selectively expressed on the surface of

53 ng oxopeptides toward cleavage by dipeptidyl peptidase 4, the principal regulator of their in vivo st

54 ral cell adhesion molecule L1 and dipeptidyl peptidase 4, were further studied.

55 ral cell adhesion molecule L1 and dipeptidyl peptidase 4.

56 Linagliptin is a dipeptidyl Peptidase-4 (DPP-4) inhibitor that inhibits the degradat

57 Dipeptidyl peptidase-4 (DPP-4) inhibitors have pleotropic anti-infl

58 an active comparator drug class, dipeptidyl peptidase-4 (DPP-4) inhibitors, in patients with type 2

59 atic degradation by inhibition of dipeptidyl peptidase-4 (DPP-4) promotes glycemic reduction for the

60 Aminopeptidases, such as dipeptidyl peptidase-4 (DPP-4, CD26), are potent therapeutic target

61 s, we identified the exopeptidase dipeptidyl peptidase-4 (DPP4) as a critical glucocorticoid-responsi

62 humans and dromedary camels using dipeptidyl peptidase-4 (DPP4) as its receptor.

63 Given the role of Dipeptidyl Peptidase-4 (DPP4) in glucose homeostasis, we further de

64 actions, as well as the effect of dipeptidyl peptidase-4 (DPP4) inhibitor on CD in endothelial-pericy

65 Dipeptidyl peptidase-4 (DPP4) modulates inflammation by enzymatic c

66 Cells marked by dipeptidyl peptidase-4 (DPP4)/CD26 expression are highly proliferat

67 ose-lowering medication-including dipeptidyl peptidase-4 inhibitor (DPP4i), insulin, or thiazolidined

68 ared the safety and efficacy of a dipeptidyl peptidase-4 inhibitor (sitagliptin) plus basal insulin w

69 omparing empagliflozin versus the dipeptidyl peptidase-4 inhibitor class, and comparing sodium-glucos

70 cotransporter-2 inhibitor versus dipeptidyl peptidase-4 inhibitor classes also produced consistent f

71 cardiovascular safety trials, the dipeptidyl peptidase-4 inhibitor linagliptin demonstrated noninferi

72 HF and related outcomes with the dipeptidyl peptidase-4 inhibitor linagliptin versus placebo in CARM

73 apagliflozin with and without the dipeptidyl peptidase-4 inhibitor saxagliptin, and the effect of dap

74 ihyperglycemic medications in the dipeptidyl peptidase-4 inhibitor, glucagon-like peptide-1 receptor

75 pagliflozin versus sitagliptin, a dipeptidyl peptidase-4 inhibitor.

76 sulfonylurea (8.7% versus 6.9%), dipeptidyl peptidase-4 inhibitors (10.6% versus 7.5%), SGLT-2i (10.

77 with thiazolidinediones (TZDs) or dipeptidyl peptidase-4 inhibitors (DPP-4is) as a third antidiabetic

78 Some but not all dipeptidyl peptidase-4 inhibitors have been associated with increas

79 by producing excessive amounts of Dipeptidyl peptidase-4, a protease that is a target of diabetes the

80 of PRSS3/mesotrypsin and kallikrein-related peptidase 5 (KLK5) in lung adenocarcinoma malignancy.

81 f existing inhibitors for kallikrein-related peptidase 5 and show that a variant with substitutions a

82 racellular protease KLK5 (kallikrein-related peptidase 5) is efficient in promoting the infectivity o

83 Kv4.2 with its auxiliary subunit dipeptidyl peptidase 6 (DPP6), and thereby modulates neuronal excit

84 Kallikrein-related peptidase 6 (KLK6) is a secreted serine protease hypothe

85 e cleavage preferences of Kallikrein-related peptidase 7 (KLK7) have previously been delineated using

86 The serine protease kallikrein-related peptidase 7 (KLK7) is a member of the human tissue kalli

87 Ubiquitin specific peptidase 7 (USP7) is a deubiquitinating enzyme (DUB) th

88 ely, USP7 (deubiquitinase ubiquitin-specific peptidase 7) opposes the activities of E3 ligases, stabi

89 12)) within the gene that encodes dipeptidyl peptidase 9 (DPP9); and on chromosome 21q22.1 (rs2236757

90 some activation in the context of dipeptidyl peptidase 9 inhibition and could thereby increase asthma

91 but decreases NLRP1 activation on dipeptidyl peptidase 9 inhibition.

92 that M1184V increases binding to dipeptidyl peptidase 9, which can account for its inhibitory role i

93 ife on Earth, the fundamental details of how peptidases accommodate posttranslational modifications,

94 endo-peptidases act first followed by the successive action o

95 of apoptosis, including apoptosome apoptotic peptidase activating factor 1 (APAF-1).

96 xperiments in vivo indicate that the PaClpP2 peptidase active site uniquely contributes to biofilm de

97 Changes in peptidase activities altered the degradation patterns of

98 ayed higher alpha-amylase, endoxylanase, and peptidase activities as well as signs of (incipient) pro

99 se, tripeptidyl peptidase, and acylaminoacyl peptidase activities have been reported previously, here

100 dases as their receptors is unknown, but the peptidase activities of the receptors are dispensable, s

101 DA1 peptidase activity also cleaves the deubiquitylase UBP15

102 te the physiological importance of both CGEP peptidase activity and its autocatalytic processing.

103 ficient proteasomes reduced both their basal peptidase activity and the stimulation by ATPgammaS.

104 The PA28 regulator stimulates 20S proteasome peptidase activity in vitro, but its role in vivo remain

105 We propose that DA1 peptidase activity regulates the duration of cell prolif

106 e proteasomes lacking Usp14 had higher basal peptidase activity than WT 26S, and this activity was st

107 le-organism catabolic process, regulation of peptidase activity, and negative regulation of cell deat

108 uitin-modified proteins independently of its peptidase activity, consistent with our recently reporte

109 he degradation of glutathione conjugates via peptidase activity.

110 type (S9D) peptidase with both exo- and endo-peptidase activity.

111 ate DA1, DAR1 and DAR2, hence reducing their peptidase activity.

112 ng alpha-amylase, protease and gamma-carboxy peptidase allowing complete sample preparation within a

113 ch are subsequently cleaved by the activated peptidase and destabilized.

114 While the combined action of signal peptide peptidase and endoplasmic reticulum (ER) aminopeptidase

115 entially cleaved by mitochondrial processing peptidase and then by octapeptidyl aminopeptidase 1 (Oct

116 eafloor (8) (mbsf) encode numerous candidate peptidases and carbohydrate-active enzymes ('CAZymes') (

117 compendium of known and putative Arabidopsis peptidases and inhibitors, and compare the distribution

118 the (near) absence of cysteine and aspartic peptidases and peptidase inhibitors, whereas other pepti

119 c data, and used to infer additional plastid peptidases and to generate a coexpression network for 97

120 peptidase, dipeptidyl peptidase, tripeptidyl peptidase, and acylaminoacyl peptidase activities have b

121 f HslV, a double-ring self-compartmentalized peptidase, and one or two AAA+ HslU ring hexamers that h

122 other serine hydrolases, including lipases, peptidases, and proteases.

123 tasis network containing protein chaperones, peptidases, and their substrate recognition factors.

124 Besides its role as a peptidase, APN also mediates signal transduction and is

125 ession and hydrolytic activities of cellular peptidases are increased upon TCR-dependent and MHC-pept

126 Thus, these peptidases are promising enzymes for the development of

127 n be removed from the transcribed peptide by peptidases, artificial and biomachines working in concer

128 Why CoV evolved to use peptidases as their receptors is unknown, but the peptid

129 However, many peptidases, as well as their functional connections and

130 Autophagy-related 4 cysteine peptidase (ATG4) proteases process inactive pro-LC3/GABA

131 ate a coexpression network for 97 organellar peptidase baits (1742 genes, making 2544 edges).

132 pt in the hydrolysate using the non-specific peptidase because of its high free amino acid content.

133 The prey peptidase becomes covalently attached to the inhibitor,

134 e the hydrolysis of protein peptide bonds by peptidases being a process essential to all life on Eart

135 at can be used to impart resistance to the d-peptidases BogQ and TriF.

136 er sequence that is excised by an N-terminal peptidase C39 domain at a double Gly motif.

137 Here we characterize a ubiquitin-activated peptidase called DA1 that limits the duration of cell pr

138 In SBS patients disaccharidases and peptidases can be upregulated in the colon.

139 d four laticifer fluids as a novel source of peptidases capable of hydrolyzing proteins in cow's milk

140 cific subsites immediately adjacent to their peptidase catalytic machinery.

141 oteolytic activity, cell envelope associated peptidase (CEP) profile and LC-MS/MS analysis of peptide

142 (Arabidopsis thaliana) chloroplast glutamyl peptidase (CGEP) is a homo-oligomeric stromal Ser-type (

143 notation based on the MEROPS nomenclature of peptidase clans and families, is incorporated into the P

144 The colibactin peptidase ClbP deacylates synthetic precolibactin 886 to

145 ies indicate that deletion of the colibactin peptidase ClbP, a modification introduced to promote acc

146 are converted to colibactins by a dedicated peptidase, ClbP.

147 Instead constitutively active signal peptidase cleaves RsiV at site-1 in a lysozyme-dependent

148 nd ClpX rotate with respect to their partner peptidase ClpP to allow function.

149 composed of a double-ring compartmentalized peptidase (ClpP) and a AAA+ unfoldase (ClpX or ClpA/ClpC

150 o the same extent as inhibitors of all three peptidases combined.

151 The peptidase compendium, including the autophagy and proteo

152 id and mitochondrial peptidases to the total peptidase complement.

153 e hydrolysate obtained from the non-specific peptidase contained a larger variety of pyrazines, inclu

154 The peptidase-containing ATP-binding cassette transporters (

155 h can be partially fulfilled by a noncognate peptidase-containing transporter component B (PctB).

156 tide receptor (GIPR), caveolin 2 (CAV2), and peptidase D (PEPD) (P-interaction < 0.05).

157 Here, we show that peptidase D (PEPD) binds and suppresses over half of nuc

158 IG BROTHER (BB) and DA2, activate the latent peptidases DA1, DAR1 and DAR2 by mono-ubiquitination at

159 known about the specificity of extracellular peptidases derived from wastewater microbial communities

160 Subsequently, these activated peptidases destabilize various positive growth regulator

161 s Alt-EJ through its SOS-response-associated-peptidase domain (SRAPd), a function that requires DNA b

162 nserved residues in the prodomain and in the peptidase domain of ADAMTS3.

163 Each PCAT contains two peptidase domains that cleave off the secretion signal,

164 dent stimulation by virtue of its ATPase and peptidase domains.

165 ion of chemokines mediated by the dipeptidyl peptidase DPP4 (CD26) has been shown to negatively regul

166 Like the closely related dipeptidyl peptidase DPPIV, the extracellular domain of FAP can be

167 Dipeptidyl peptidases (DPPs) are proteolytic enzymes that are ideal

168 rolyzed (i.e., inactivated) by extracellular peptidases during biological wastewater treatment, there

169 terization of the dual function macrocyclase-peptidase enzyme involved in the biosynthesis of the hig

170 , cerliponase alfa (Brineura), a tripeptidyl peptidase enzyme replacement therapy, became the first g

171 emonstrated for steroid-binding proteins and peptidase enzymes.

172 nal anchors, whose cleavage via the prepilin peptidase, essential for pilin membrane extraction and a

173 ases and peptidase inhibitors, whereas other peptidase families were exclusively organellar; reasons

174 and they comprise the largest of all of the peptidase families, their dynamic motions remain obscure

175 sively hydrolysed firstly by endogenous endo-peptidases followed by the successive action of exo-pept

176 conserved activity as an internal processing peptidase for complex mitochondrial precursor proteins.

177 e, chymosine, thermolysin and a non-specific peptidase from Aspergillus melleus), contained a varying

178 The visceral peptidase from farmed giant catfish could be an alternat

179 The peptidase from the viscera of farmed giant catfish was u

180 The latex peptidases from Calotropis procera (CpLP), Cryptostegia

181 We identified Germ Cell Nuclear Acidic Peptidase (GCNA) as a conserved regulator of genome stab

182 Peptidase-generated oligopeptide QS signals being receiv

183 by P. gingivalis are the essential cysteine peptidases gingipain K (Kgp) and R (RgpA and RgpB), whic

184 CFEs were suitable sources of peptidases, glutamate dehydrogenase and cystathionine ga

185 oluble proteins, the H-segment of the leader peptidase helix used in the von Heijne and White biologi

186 were more resistant to proteolysis by latex peptidases; however, heat pretreatment of the whey prote

187 Signal peptidase I (SpI) cleavage sites were found in 463 of th

188 n criteria included the presence of a signal peptidase I cleavage site, a predicted beta-barrel fold,

189 dipeptidly-peptidase I) is a widely expressed, exo-cystein-protease

190 Here, we identify a pilin peptidase iamP, and LysR-type regulator (LRTR) iamR, tha

191 secretion by altering the activity of signal peptidase IB.

192 he signal sequence is then cleaved by signal peptidase II (LspA) to give an N-terminal S-diacylglycer

193 in signal peptide recognition site of signal peptidase II (SpII).

194 Tripeptidyl peptidase II (TPPII) is a eukaryotic protease acting dow

195 a-amylase, alpha-glucosidase, and dipeptidyl peptidase III (DPP III) enzyme activities.

196 The presence of peptidase in vB_RpoMi-Mini genome further implies that h

197 reticulum aminopeptidases (ERAPs), the final peptidases in the antigen-presentation pathway.

198 cF Thr74Ile, and Asp486Glu in a hypothetical peptidase) in previously unrecognized S. aureus virulenc

199 In uncovering a peptidase-independent function for PCS1, we reveal this

200 Peptidase inhibitor 3 (PI3), a gene in the antimicrobial

201 Missense mutations in the serine peptidase inhibitor Kazal type 5 (SPINK5) skin barrier g

202 iation between low circulating plasma serine peptidase inhibitor Kunitz type-1 (SPINT1) concentration

203 coding alpha-1 antitrypsin, SERPINA1 (serpin peptidase inhibitor, clade A, member 1), in determining

204 8 (MTRNRL8), interleukin-8 (IL8), and serpin peptidase inhibitor, clade H (SERPINH1) and chemokine li

205 Peptidase inhibitors (PIs) have been broadly studied due

206 ses and identified IL-1 cytokines and serine peptidase inhibitors as the most dysregulated esophagus-

207 alin was doubled by application of all three peptidase inhibitors combined.

208 al microglia or adult microglia treated with peptidase inhibitors into spinal cord lesions of adult m

209 ike peptide 1 (GLP1) mimetics and dipeptidyl peptidase inhibitors that enhance GLP1 receptor activati

210 for enkephalin activity, we applied specific peptidase inhibitors to determine which peptidase(s) reg

211 ress several extracellular and intracellular peptidase inhibitors, as well as other molecules that ar

212 ence of cysteine and aspartic peptidases and peptidase inhibitors, whereas other peptidase families w

213 a mechanism that was partially prevented by peptidase inhibitors.

214 Amnesiac and Neprilysin 1 (Nep1), a membrane peptidase involved in memory and expressed in the MB.

215 letal muscle cells, insulin-responsive amino peptidase (IRAP) along with glucose transporter 4 (Glut4

216 ing organ growth in Arabidopsis thaliana The peptidase is activated by two RING E3 ligases, Big Broth

217 ctivation protein (FAP), a membrane-anchored peptidase, is highly expressed in cancer-associated fibr

218 otein of L. major, named inhibitor of serine peptidases (ISP) 2, inactivates neutrophil elastase (NE)

219 idly inactivated by the action of dipeptidyl peptidase IV (DPP-4) which limits their use as therapeut

220 sin-I-converting enzyme (ACE) and dipeptidyl peptidase IV (DPP-IV) inhibitory activities, with inhibi

221 ensin converting enzyme (ACE) and dipeptidyl peptidase IV (DPP-IV) inhibitory and oxygen radical abso

222 Nine novel dipeptidyl peptidase IV (DPP-IV) inhibitory peptides (FLQY, FQLGASP

223 s used to optimise the release of dipeptidyl peptidase IV (DPP-IV) inhibitory peptides during hydroly

224 Camel milk proteins contain dipeptidyl peptidase IV (DPP-IV) inhibitory peptides.

225 mong them primarily inhibition of dipeptidyl peptidase IV and angiotensin-converting enzyme.

226 y and histochemical estimation of dipeptidyl-peptidase IV enzyme activity of donor cells in the negat

227 The highest dipeptidyl peptidase IV inhibitory activity was obtained by the com

228 e and senescent rats deficient in dipeptidyl-peptidase IV.

229 e (37.8%), alpha-amylase (35.6%), dipeptidyl peptidase-IV (34.4%), reactive oxygen species (81.6%), a

230 riety of bioactivities, including dipeptidyl peptidase-IV (DPP-IV) and angiotensin converting enzyme

231 d clinical variants, for example, dipeptidyl peptidase-IV inhibitor-associated noninflammatory bullou

232 ne proteases known as the kallikrein-related peptidases (KLKs).

233 nst a hepatic surface protein, leucine amino peptidase (LAP).

234 Signal peptide peptidase-like 2a (SPPL2a) is an aspartyl intramembrane

235 nd the intramembrane protease signal peptide peptidase-like 2a (SPPL2a).

236 f the intramembrane proteases signal peptide peptidase-like 2a and b (SPPL2a/b).

237 rough proteolytic cleavage by signal peptide peptidase-like 2a.

238 amino acid synthase/hydrolase called PM20D1 (peptidase M20 domain containing 1).

239 rst followed by the successive action of exo-peptidases (mainly, tri- and di-peptidylpeptidases, amin

240 ses followed by the successive action of exo-peptidases, mainly, tri- and di-peptidylpeptidases, amin

241 This peptidase may be a target for regulation of endogenous o

242 Inhibiting peptidases may be an attractive method to enhance endoge

243 s coeruleus, and spinal cord, where multiple peptidases metabolize enkephalin.

244 n between GRP75 and mitochondrial processing peptidase (MPP), which makes frataxin more accessible to

245 cleaved off by the mitochondrial processing peptidase (MPP).

246 However, a more widely expressed islet peptidase, neprilysin, degrades angiotensin-(1-7) into s

247 des a systematic insight into the organellar peptidase network in Arabidopsis thaliana We present a c

248 onal choices of drugs targeting the specific peptidase of interest.

249 Cruzipain, the main papain-like cysteine peptidase of T. cruzi, is an important virulence factor

250 pact of Aqualysin 1 (Aq1), the thermo-active peptidase of Thermus aquaticus, on wheat albumin, globul

251 Serine peptidases of the prolyl oligopeptidase (POP) family are

252 form of OPA1 (L-OPA1) by the stress-induced peptidase OMA1.

253 Nevertheless, we did not detect any YbAnbu peptidase or amidase activity.

254 an increase in the level of the neprilysin 1 peptidase overcomes memory deficits induced by amyloid p

255 to as the C39 domain, or referred to as the peptidase (PEP) domain.

256 Hydrolysates, obtained with different peptidases (pepsine, chymosine, thermolysin and a non-sp

257 ions of both pilA1 and pilA2 or the prepilin peptidase, PibD, show the reduction in the number of pil

258 ed principles for processing by the prepilin peptidase PilD and for assembly into filaments; (ii) dis

259 Casein hydrolysis by Plumeria rubra latex peptidases (PrLP) was negligible.

260 This insight builds upon the paradigm of how peptidases recognize substrates and provides a molecular

261 hibitors of mosquito peptidyl dipeptidase, a peptidase related to mammalian angiotensin-converting en

262 Heat-stable peptidases released in refrigerated raw milk by psychrot

263 y a lack of information regarding a protease/peptidase required for the excision of an early, cross-l

264 Redistribution was blocked by a peptidase-resistant version of ZIP and by treatment with

265 This indicates neprilysin is the predominant peptidase responsible for degrading enkephalins in the i

266 equencing that mutations in ASPRV1 (aspartic peptidase retroviral-like 1) cause a dominant Mendelian

267 ght the importance of knowing which specific peptidase(s) control opioid actions in the relevant neur

268 ific peptidase inhibitors to determine which peptidase(s) regulate enkephalin signaling in this regio

269 ling; however, we do not know which specific peptidase(s) to target.

270 In a milk-clotting assay, this peptidase showed maximal milk clotting activity at 60-65

271 The three peptidases showed selectivity for different glycans, rev

272 ed crystal structures of the LysM/M23 family peptidase ShyA, the primary EP of the cholera pathogen V

273 lly processed by the cell membrane-localized peptidase sortase A, which cleaves the LPXTG motif.

274 Here, we show that signal peptide peptidase (SPP) modulates the ER shape through degradati

275 glycoprotein K (gK) binds to signal peptide peptidase (SPP), also known as minor histocompatibility

276 s of the human HMCES SOS response-associated peptidase (SRAP) domain in complex with DNA-damage subst

277 utionarily conserved SOS-response associated peptidase (SRAP) domain of HMCES and its Escherichia col

278 l activity and have significantly enhanced d-peptidase stability.

279 e describe a general approach for predicting peptidase substrates de novo using protein structure mod

280 the specificity of different classes of ClpP peptidase subunits contributes to the biological outcome

281 Of these, 237 related to proteases and peptidases, suggesting a bacterial component to the pre-

282 p1) is an integral thylakoid membrane signal peptidase that requires an intramolecular disulfide bond

283 References 912 Subtilases (SBTs) are serine peptidases that are found in all three domains of life.

284 tatins are reversible inhibitors of cysteine peptidases that are found naturally in plants.

285 d-Stereoselective peptidases that degrade nonribosomal peptides (NRPs) wer

286 In the presence of the peptidase, the reactive intermediates are converted to a

287 ase/translocase that functions with the ClpP peptidase to degrade proteins that are damaged or unneed

288 teins can also be isolated and hydrolysed by peptidases to produce hydrolysates.

289 he distribution of plastid and mitochondrial peptidases to the total peptidase complement.

290 Although endopeptidase, dipeptidyl peptidase, tripeptidyl peptidase, and acylaminoacyl pept

291 Peptides generated by the action of peptidases upon cheese proteins were separated by revers

292 in modifier ISG15 and the ubiquitin specific peptidase USP18.

293 f the transcripts encoding putative secreted peptidases were assigned to lineages (7,13,14) of uncult

294 Kinases, phosphatases, proteases, and peptidases were the most common targets, fluorescent ass

295 s showed that the gene encoding pyroglutamyl peptidase, which removes N-terminal OP residues, cluster

296 ivity, but its action is strongly limited by peptidases, which degrade enkephalin into inactive fragm

297 s lspB, a gene encoding a lipoprotein signal peptidase whose expression appears detrimental for infec

298 uantify other endogenous peptides cleaved by peptidases whose concentrations are below 1 pM.

299 is a homo-oligomeric stromal Ser-type (S9D) peptidase with both exo- and endo-peptidase activity.

300 Our results revealed an aspartic peptidase with molecular mass approximately 38kDa, maxim