ライフサイエンスコーパス: peptide hormone

1 of ghrelin, a secreted metabolism-regulating peptide hormone.

2 n large part by the N-terminal domain of the peptide hormone.

3 ent subtilase that releases a very different peptide hormone.

4 g receptor selectivity in this fast evolving peptide hormone.

5 e induced by repeated administrations of the peptide hormone.

6 idates including Neuromedin U, a circulating peptide hormone.

7 his region for full agonist activity of this peptide hormone.

8 domain, and their signalling is regulated by peptide hormones.

9 py loss-of-function states for the indicated peptide hormones.

10 for developing stabilized analogues of other peptide hormones.

11 ncluding neuropeptides, biogenic amines, and peptide hormones.

12 citonin, and other therapeutically important peptide hormones.

13 to provide an extensive map of O-glycans on peptide hormones.

14 ase 1 in response to many growth factors and peptide hormones.

15 endogenously stimulated by moderately large peptide hormones.

16 receptors has been implicated in binding to peptide hormones.

17 erence in the biological activities of these peptide hormones.

18 e the regulated release of neuropeptides and peptide hormones.

19 the knowledgebase of this critical class of peptide hormones.

20 ectables and can likely be extended to other peptide hormones.

21 metabolic products of neurotransmitters and peptide hormones, a novel consequence of the phenomenon

22 coupled receptor that, when activated by the peptide hormone ACTH, stimulates cAMP production and adr

23 The peptide hormone acyl-ghrelin and its receptor, GHSR(1a),

24 In the human adrenal cortex, the peptide hormone adrenocorticotropin (ACTH) directs corti

25 The 52 amino acid peptide hormone adrenomedullin (ADM) plays a major role

26 Here, we report a novel role for the peptide hormone adropin in regulating substrate oxidatio

27 The peptide hormone adropin regulates energy metabolism in s

28 ialized endocrine cells secrete a variety of peptide hormones all along the gastrointestinal (GI) tra

29 s spectrometry, we profiled the gradients of peptide hormones along the human and mouse gut, includin

30 Aggregation of the peptide hormone amylin into amyloid deposits is a pathol

31 To develop novel proteolysis-resistant peptide hormone analogs, we utilize a strategy that reli

32 Gastrin is a peptide hormone and an important factor in determining t

33 r work reveals a novel mechanism integrating peptide hormone and auxin signaling in the regulation of

34 ence of HID-1 results in specific defects in peptide hormone and monoamine storage and regulated secr

35 Hepcidin is a liver-derived peptide hormone and the master regulator of systemic iro

36 This enzyme is able to activate/inactivate peptide hormones and could be involved in a cascade of e

37 of G protein-coupled receptors (GPCRs) bind peptide hormones and have causal roles in many diseases,

38 , inhibition of inflammation, the release of peptide hormones and modulation of fever.

39 Peptide hormones and neuropeptides encompass a large cla

40 that most proteins participate in producing peptide hormones and neurotransmitters, enzymes, and the

41 en the importance of insulin and its related peptide hormones and previous studies of glycosylated in

42 Peptide hormones and their cognate receptors belonging t

43 Peptide hormones and their receptors are widespread in m

44 ing a TIR domain-containing protein, a plant peptide hormone, and many OLIGO PEPTIDE TRANSPORTER gene

45 ortance of O-glycosylation in the biology of peptide hormones, and our map of O-glycosites in this la

46 a rich source of bioactive molecules such as peptides, hormones, and neurotransmitters, but relativel

47 Extracellular NaCl concentrations and the peptide hormone angiotensin II (AngII) are two major neu

48 We report that overproduction of the peptide hormone Angiotensin II (AngII) in tumor-bearing

49 matic activity is responsible for processing peptide hormones angiotensin III and IV.

50 ), cytokinin (CK), brassinosteroids (BR) and peptide hormones are also implicated in plant defence si

51 Peptide hormones are attractive as injectable therapeuti

52 CLE peptide hormones are critical regulators of many cell pr

53 Peptide hormones are implicated in many important aspect

54 Peptide hormones are key physiological regulators, and m

55 Peptide hormones are powerful regulators of various biol

56 Neurotransmitters and peptide hormones are secreted by regulated vesicle exocy

57 Neuropeptides and peptide hormones are stored in the amyloid state in dens

58 he previously held paradigm that steroid and peptide hormones are the primary regulators of mammary g

59 -related increases in circulating ghrelin, a peptide hormone, are necessary and sufficient for stress

60 processing of proglucagon yields three major peptide hormones as follows: glucagon in the alpha cells

61 polypeptide (IAPP or amylin) is a 37-residue peptide hormone associated with glucose metabolism that

62 kinases (LRR-RKs) to sense sequence diverse peptide hormones at the cell surface.

63 ulating the secretion of the cardiac-derived peptide hormone, atrial natriuretic peptide.

64 , they do not differentiate to express their peptide hormone battery, nor do they project an axon via

65 IAPP, a 37 amino-acid peptide hormone belonging to the calcitonin family, is a

66 6 amino acids with two functional domains, a peptide hormone-binding domain and a G-protein-coupled r

67 re all members of the insulin superfamily of peptide hormones but bind to several distinct classes of

68 way, allows for high-affinity sensing of the peptide hormone by binding to an Arg-His-Asn motif in ID

69 Regulated secretion of neuropeptides and peptide hormones by secretory granules (SGs) is central

70 The peptide hormone calcitonin is intimately connected with

71 olysis-resistant variants of other important peptide hormones can also be found using this strategy t

72 In the pituitary gland, peptide hormones can be stored as amyloid fibrils within

73 rids (phybrids) comprising covalently linked peptide hormones can leverage independent biological pat

74 that almost one third of the 279 classified peptide hormones carry O-glycans.

75 dentify aberrant beta cell expression of the peptide hormone cholecystokinin (Cck) in response to obe

76 d extracellular loop of the receptor for the peptide hormone, cholecystokinin.

77 Ghrelin, a peripherally produced peptide hormone, circulates at high concentrations durin

78 ation of islet amyloid polypeptide (IAPP), a peptide hormone co-synthesized and co-stored with insuli

79 rgising with the actions of locally elevated peptide hormone concentrations.

80 Calcitonin is a peptide hormone consisting of 32 amino acid residues and

81 and the complicated topology of this 51-mer peptide hormone consisting of two chains and three disul

82 ike peptide 5 (INSL5) is a complex two-chain peptide hormone constrained by three disulfide bonds in

83 Hepcidin is a tightly folded 25-residue peptide hormone containing four disulfide bonds, which h

84 Islet amyloid polypeptide (IAPP) is a peptide hormone cosecreted with insulin by pancreatic be

85 ssue by determining the mechanism by which a peptide hormone, crustacean cardioactive peptide (CCAP),

86 ting to the VTA were suppressed by leptin, a peptide hormone derived from adipocytes that signals per

87 hytosulfokines (PSKs) are secreted, sulfated peptide hormones derived from larger prepropeptide precu

88 r, they provide evidence that the endogenous peptide hormone does not function as an activator per se

89 r numbers of known bioactive peptides (e.g., peptide hormones) during the analysis of gut samples, su

90 rine cells, including those that secrete the peptide hormones (e.g., ghrelin and glucagon-like peptid

91 he ECD scaffold and the helical structure of peptide hormones emphasizes this hot dog model as a gene

92 inducible and ABA/sugar-repressible putative peptide hormone encoded by GASA6 was severely repressed

93 Adropin is a peptide hormone encoded by the Energy Homeostasis Associ

94 Mouse studies linking adropin, a peptide hormone encoded by the energy homeostasis-associ

95 Peptide hormones encoded by H. sacchari CLE effectors ar

96 cades of research have demonstrated that the peptide hormone endothelin-1 (ET-1) plays multiple, comp

97 Evolution often diversifies a peptide hormone family into multiple subfamilies, which

98 The corticotropin-releasing factor (CRF) peptide hormone family members coordinate endocrine, beh

99 Peptide hormone fibroblast growth factor-21 (FGF21) has

100 ription 3 (Stat3) transduces signals of many peptide hormones from the cell surface to the nucleus an

101 Recently, peptide hormones from the nervous system have been shown

102 d to developing therapeutics targeting other peptide hormone G protein-coupled receptors.

103 The peptide hormone gastrin exerts a suppressive effect on a

104 site is shared by the human gastrointestinal peptide hormones gastrin and cholecystokinin.

105 The peptide hormone ghrelin acts in the central nervous syst

106 The peptide hormone ghrelin exerts pleiotropic effects inclu

107 The peptide hormone ghrelin is important for both homeostati

108 The peptide hormone ghrelin is the endogenous ligand for the

109 The peptide hormone ghrelin is the only known protein modifi

110 n octanoyl group to the appetite-stimulating peptide hormone ghrelin, potentially preventing obesity.

111 d behavior was dependent on signaling by the peptide hormone ghrelin.

112 he glucagon receptor (GCGR) activated by the peptide hormone glucagon is a seven-transmembrane G prot

113 The peptide hormone glucagon-like peptide-1 (GLP-1) enhances

114 Peptide hormones governing many developmental processes

115 etformin increases circulating levels of the peptide hormone growth/differentiation factor 15 (GDF15)

116 mor-homing peptides, antimicrobial peptides, peptide hormones, growth factors and matrix metalloprote

117 Complementary surfaces are buried when peptide hormones, growth factors, or cytokines bind and

118 crude ETEC filtrates, purified STa, and the peptide hormone guanylin.

119 Motilin, a peptide hormone has a direct excitatory effect on circul

120 Hepcidin, an antimicrobial-like peptide hormone, has emerged as the master regulator of

121 PCRs), cell-surface proteins that respond to peptide hormones, has been restricted to the amino-termi

122 herapeutic properties of recombinant relaxin peptide hormone have been investigated in several diseas

123 The peptide hormone hepcidin (Hepc) limits iron uptake from

124 entral role is related to the secretion of a peptide hormone hepcidin by hepatocytes.

125 The hepatic peptide hormone hepcidin controls the duodenal absorptio

126 A major focus is on the regulation of the peptide hormone hepcidin during the inflammatory respons

127 The hepatic peptide hormone hepcidin is considered the central regul

128 The hepatic peptide hormone hepcidin is the principal regulator of i

129 The peptide hormone hepcidin is the principal regulator of s

130 Levels of the peptide hormone hepcidin negatively correlate with syste

131 The peptide hormone hepcidin regulates iron metabolism in re

132 The peptide hormone hepcidin regulates iron metabolism, and

133 The peptide hormone hepcidin regulates mammalian iron homeos

134 emic iron balance is controlled by the liver peptide hormone hepcidin, which is transcriptionally reg

135 iron exporter ferroportin and its regulatory peptide hormone hepcidin.

136 signaling induces hepatic expression of the peptide hormone hepcidin.

137 Ferroportin is inhibited by a peptide hormone, hepcidin.

138 omeostasis is regulated by the liver-derived peptide hormone, hepcidin.

139 The peptide hormone human relaxin-2 (H2-RLX) has emerged as

140 epeat receptor kinase (LRR-RK) HAESA and the peptide hormone IDA.

141 to fibrillation of human calcitonin (hCT), a peptide hormone important in calcium metabolism.

142 Hepcidin is the key peptide hormone in iron homeostasis, and is secreted pre

143 urther support the concept of C-peptide as a peptide hormone in its own right and suggest a potential

144 ly conserved sequences, we predicted another peptide hormone in pro-somatostatin and named it neurono

145 trol and prolong the bioactivity of a native peptide hormone in vivo.

146 rk for the recognition of sequence-divergent peptide hormones in plants.

147 ic enzyme for the production of POMC-derived peptide hormones in secretory vesicles.

148 ction of ACTH, beta-endorphin, and alpha-MSH peptide hormones in the regulated secretory pathway.

149 mice that have defects in the production of peptide hormones, in the function of cell membrane recep

150 ropin releasing factor (CRF)/urocortin (Ucn) peptide hormones include four structurally similar pepti

151 Several peptide hormones including bradykinin and angiotensin I

152 embers of the oxytocin/vasopressin family of peptide hormones induce in Hirudo verbana a sequence of

153 rally through secretion of adipocyte-derived peptide hormones, inflammatory mediators, signaling lipi

154 Peptide hormones, initially identified in the periphery

155 upregulation of the mannose-6-phosphate- and peptide hormone-interacting receptor IGF2R, which is a p

156 ptide binding in which the C terminus of the peptide hormone interacts almost exclusively with the N-

157 served that a major portion of both of these peptide hormones interacts with the phospholipid head gr

158 Hepcidin-25 is a peptide hormone involved in iron absorption and homeosta

159 Ghrelin is a peptide hormone involved in regulation of appetite, gluc

160 rs (GPCRs) respond to paracrine or endocrine peptide hormones involved in control of bone homeostasis

161 nt techniques to determine specific forms of peptide hormones involved in physiologic processes; inve

162 in the concentration of functionally related peptide hormones is critical to understanding the etiolo

163 However, the remodelling capacity of these peptide hormones is difficult to study in chronic settin

164 Hepcidin, a peptide hormone, is a key regulator in mammalian iron ho

165 Hepcidin, an iron regulatory peptide hormone, is altered in subjects with COPD; howev

166 The 37-residue peptide hormone islet amyloid polypeptide (IAPP) plays a

167 Calcitonin is a 32-residue peptide hormone known for its hypocalcemic effect and it

168 s system cells but does not co-localize with peptide hormones known to elicit molting behavior, sugge

169 1) and cholecystokinin (CCK) are gut-derived peptide hormones known to play important roles in the re

170 isting variation in a subfamily of plant CLE peptide hormones leads to a synthetic bifunctional pepti

171 on of the receptor for the adipocyte-derived peptide hormone leptin (OB-R) is a characteristic featur

172 For both D. ocoee and E. guttolineata, peptide hormone-like transcripts occur at high frequency

173 PanNET) universally hypersecrete one or more peptide hormones, likely sensitizing these cells to high

174 Hepcidin, a peptide hormone made in the liver, is the principal regu

175 In contrast to animals, data for plant peptide hormone maturation are scarce and the specificit

176 l electron transport, iron mobilization, and peptide hormone maturation.

177 l electron transport, iron mobilization, and peptide hormone maturation.

178 s for RaxX function as an immunogen and host peptide hormone mimic.

179 This is exemplified by the plant-peptide hormone mimics, the CLAVATA3/EMBRYO SURROUNDING

180 by the discovery of hepcidin, the main serum peptide hormone negative regulator of body iron.

181 tegrated to obtain a structural model of the peptide hormone neuropeptide Y (NPY) bound to its human

182 sults support the hypothesis that packing of peptide hormones/neuropeptides in dense-core vesicles do

183 quence of OCN predicts that, like many other peptide hormones, OCN is first synthesized as a prohormo

184 Like many peptide hormones, OCN is subjected to post-translational

185 stimulating factor (G-CSF) is an endogenous peptide hormone of the hematopoietic system that has bee

186 stimulating factor (G-CSF) is an endogenous peptide hormone of the hematopoietic system that has ent

187 7) [Ang-(1-7)] is an endogenous 7-amino acid peptide hormone of the renin-angiotensin system that has

188 hrough modulating the actions of circulating peptide hormones on the brain.

189 In particular, the peptide hormone osteocalcin, which is made by bone and f

190 The peptide hormone oxytocin (OXT) exhibits anxiolytic-like

191 ether endogenous neuromodulators such as the peptide hormone oxytocin (OXT) influence the chemosensor

192 The peptide hormone oxytocin is an established regulator of

193 reactivity, we intranasally administered the peptide hormone oxytocin to the same 57 individuals in a

194 Two peptide hormones, oxytocin and vasopressin, are also ass

195 zes recent progress on the identification of peptide hormones participating in the pathophysiology of

196 Here, we describe a growth-promoting peptide hormone, phytosulfokine (PSK), as attenuating PT

197 dies have demonstrated that oxytocin (OT), a peptide hormone, plays an important role in regulating m

198 es involved in the proteolytic maturation of peptide hormone precursors and are implicated in a varie

199 proteolytic maturation of a large number of peptide hormone precursors.

200 Relaxin, a peptide hormone produced during pregnancy, is involved i

201 Inhibin is a heterodimeric peptide hormone produced in the ovary that antagonizes a

202 Ghrelin, an octanoylated peptide hormone produced in the stomach, rises dramatica

203 Leptin, a peptide hormone produced primarily by the adipocytes, is

204 ology and mass spectrometry, we identified a peptide hormone product of the gastrin gene (glycine-ext

205 a and represent the best refined models of a peptide hormone receptor in this important family.

206 iverse plant peptides, suggesting that plant peptide hormone receptors may share a common ligand bind

207 ptor (GIPR), are three metabolically related peptide hormone receptors.

208 n agonist at three key metabolically-related peptide hormone receptors: glucagon-like peptide-1 (GLP-

209 sponsible of the degradation of the incretin peptide hormones regulating blood glucose levels.

210 ation using short-term administration of the peptide hormone relaxin (RLN).

211 The peptide hormone relaxin is showing potential as a treatm

212 Herein, the naturally occurring peptide hormone relaxin-2 is administered for the treatm

213 recombinant form of the naturally occurring peptide hormone relaxin-2, is a pleiotropic vasodilating

214 The ovarian peptide hormone, relaxin, circulates during pregnancy, c

215 eyond the widely accepted role of regulating peptide hormone release from enteroendocrine cells in th

216 Angiotensin II (AngII), a peptide hormone released by adipocytes, can be cataboliz

217 Secretin is a peptide hormone released from the duodenum to stimulate

218 d (acoustic) extraction of insulin and other peptide hormones released from freshly prepared islets,

219 edullin (Adm, gene; AM, protein)-a mitogenic peptide hormone required for normal cardiovascular devel

220 as a regulator connecting sugar, ABA, GA and peptide hormone responses.

221 ractions and signalling networks involving a peptide hormone, root meristem growth factor 1 (RGF1)(1)

222 at subtle changes in the native structure of peptide hormone(s) could alter its conformational dynami

223 ere we investigate GAG interactions with the peptide hormone salmon calcitonin (sCT).

224 Leptin is a peptide hormone secreted by adipose tissue and regulates

225 lin is a 28 amino acid, appetite-stimulating peptide hormone secreted by the food-deprived stomach.

226 Hepcidin is a peptide hormone secreted by the liver that plays a centr

227 mic iron balance is regulated by hepcidin, a peptide hormone secreted by the liver.

228 Ghrelin is an endogenous peptide hormone secreted primarily by the stomach and is

229 Ghrelin is an orexigenic gastric peptide hormone secreted when caloric intake is limited.

230 gulates the expression of genes encoding the peptide hormones secreted by each cell type, including t

231 Hepcidin, a cysteine-rich peptide hormone, secreted mainly by the liver, plays a c

232 The gastrointestinal peptide hormone, secretin (SCT) that binds to secretin r

233 rantee continuous availability and function, peptide hormone secretion must be tightly coupled to its

234 ein expressed in cells with stimulus-coupled peptide hormone secretion, including pancreatic beta cel

235 These synthetic peptide hormones share the overall structure of GLP-1 an

236 to study the mechanisms by which steroid and peptide hormone signaling control gene expression.

237 The endocrine system mediates long-range peptide hormone signaling to broadcast changes in metabo

238 egation and fibril reversibility of a cyclic peptide hormone somatostatin (SST)-14 using various tech

239 imide bridge, and this is illustrated on the peptide hormone somatostatin.

240 udies define mechanisms for gastrointestinal peptide hormone stimulation of glucose uptake.

241 H2-relaxin (RLN2) is a two-chain peptide hormone structurally related to insulin with a t

242 Heart muscle cells produce peptide hormones such as natriuretic peptides.

243 PC2), an enzyme involved in the synthesis of peptide hormones, such as glucagon and proopiomelanocort

244 mammals, the production of insulin and other peptide hormones, such as the islet amyloid polypeptide

245 utocrine feedback mechanism in regulation of peptide hormone synthesis.

246 tropin-releasing hormone (GnRH) is a trophic peptide hormone synthesized by hypothalamic neurons and

247 -Fc(mIgG)-Leptin, a bifunctional therapeutic peptide hormone that combines the glucagon-like peptide

248 e peptide 1 (GLP-1) is a 30 or 31 amino acid peptide hormone that contributes to the physiological re

249 Hepcidin is a liver-derived peptide hormone that controls systemic iron homeostasis.

250 Hepcidin, a peptide hormone that decreases intestinal iron absorptio

251 Hepcidin is a peptide hormone that functions as a key regulator of mam

252 Atrial natriuretic peptide (ANP) is a peptide hormone that in response to atrial stretch is se

253 Cholecystokinin (CCK) is a peptide hormone that induces bile release into the intes

254 Somatostatin (SS) is a peptide hormone that inhibits insulin secretion in beta-

255 ation factor 1 (AtRALF1) is a small secreted peptide hormone that inhibits root growth by repressing

256 Ghrelin (Grln) is a peptide hormone that is predominantly produced in the st

257 abscission in Arabidopsis is regulated by a peptide hormone that is released from its precursor by a

258 Glucagon-like peptide 1 (GLP-1) is a peptide hormone that is released from the gut in respons

259 l natriuretic peptide (ANP) is an endogenous peptide hormone that is synthesized and secreted by the

260 Fibroblast growth factor 21 (FGF21) is a peptide hormone that is synthesized by several organs an

261 Relaxin is a peptide hormone that mediates antifibrotic effects throu

262 tropin-releasing hormone (GnRH) is a trophic peptide hormone that modulates reproductive function and

263 Hepcidin is a peptide hormone that negatively regulates iron egress fr

264 Hepcidin is a peptide hormone that regulates iron homeostasis and acts

265 e intestine secrete cholecystokinin (CCK), a peptide hormone that stimulates digestion of fat and pro

266 Ghrelin is a peptide hormone that stimulates growth hormone (GH) rele

267 n of this strategy to oxyntomodulin (OXM), a peptide hormone that stimulates insulin secretion from i

268 ich is processed to ghrelin, an octanoylated peptide hormone that stimulates release of growth hormon

269 Ghrelin is a gastric peptide hormone that stimulates weight gain in vertebrat

270 Angiotensin II (Ang II) is a peptide hormone that, like many cytokines, acts as a pro

271 o proteolytically process a diverse suite of peptide hormones that coordinate larval and pupal growth

272 thesis coupling for glucagon, one of several peptide hormones that increase blood glucose levels.

273 quences homologous to other classes of plant peptide hormones that may be utilized by these pests.

274 Hepcidin-25 is a peptide-hormone that has been proposed as the key biomar

275 e main amyloidogenic region from the insulin peptide hormone, the LVEALYL heptapeptide.

276 cardioactive peptide (CCAP) neurons and the peptide hormones they secrete are critical for ecdysis;

277 ue role as the sole blood glucose-decreasing peptide hormone, this coupling is considered an exceptio

278 the first to report DOPA cross-linking of a peptide hormone to a GPCR and the first to identify a re

279 nd imipramine pamoate (Tofranil-PM); and the peptide hormones triptorelin pamoate (Trelstar) and octr

280 The peptide hormone Urocortin 3 (Ucn 3) is abundantly and ex

281 The peptide hormone urocortin3 (Ucn3) is abundantly expresse

282 Although the circulating level of peptide hormone urotensin II (UII) and kidney tissue exp

283 Neuropeptides are peptide hormones used as chemical signals by the neuroen

284 kidney is regulated by the neurohypophyseal peptide hormone vasopressin through actions in renal col

285 chanism that accounts for the ability of the peptide hormone vasopressin to regulate water excretion

286 urons (MNC) which synthesize and release the peptide hormones vasopressin and oxytocin.

287 ocrine tissues secrete neurotransmitters and peptide hormones via large dense-core vesicles (LDCVs).

288 aracterize conformational changes induced by peptide hormones, we investigated interactions of the cl

289 interactions at the N-terminal domain of the peptide hormone were manifested by suppressed cAMP gener

290 Several peptide hormones were recently suggested to be stored as

291 IAPP is a 37-residue peptide hormone which forms amyloid fibers in individual

292 t amyloid polypeptide (IAPP) is a 37-residue peptide hormone whose deposition as amyloid fibrils in t

293 Apelin is an important mammalian peptide hormone with a range of physiological roles, esp

294 recombinant human relaxin-2, is a vasoactive peptide hormone with many biological and haemodynamic ef

295 Adrenomedullin (AM) is a peptide hormone with numerous effects in the vascular sy

296 Fibroblast growth factor 21 (FGF21), a peptide hormone with pleiotropic effects on carbohydrate

297 iuretic peptides (NPs) are cyclic vasoactive peptide hormones with high therapeutic potential.

298 Thus, two peptide hormones with opposing action in weight regulati

299 The storage of protein/peptide hormones within subcellular compartments and sub

300 A nonradioactive label for peptide hormones would be useful for pharmacokinetic stu