ライフサイエンスコーパス: peptide motif

1 e were glycan dependent or targeted the GDIR peptide motif.

2 l antigen sensitivity and recognize the same peptide motif.

3 d peptides containing an appropriate HLA-B35 peptide motif.

4 event blocks ADAP-SH3c domain binding to the peptide motif.

5 eins are known to be mediated by a conserved peptide motif.

6 has defined the binding pocket for the LXCXE peptide motif.

7 ind ligands containing the Arg-Gly-Asp (RGD) peptide motif.

8 ire ICD sequence, rather than a short linear peptide motif.

9 ich is instead mediated by a short cytosolic peptide motif.

10 host macrophages with its ELR (Glu-Leu-Arg) peptide motif.

11 a variety of interactions and bind distinct peptide motifs.

12 by the activators' short acidic-hydrophobic peptide motifs.

13 n components through their carboxyl-terminal peptide motifs.

14 been found which recognize specific internal peptide motifs.

15 tions with endocytic adaptors containing F&H peptide motifs.

16 ined by a common fold and a set of conserved peptide motifs.

17 us A (PVA) proteinases that cleave different peptide motifs.

18 redicted by encoded transmembrane and leader peptide motifs.

19 GXM), is highly protective and binds several peptide motifs.

20 SH3 domains interact with proline-rich peptide motifs.

21 ide interaction does not utilise established peptide motifs.

22 be segregated into four groups according to peptide motifs.

23 Cas9 fused with single-stranded DNA binding peptide motifs.

24 dues surrounded by conformationally flexible peptide motifs.

25 ble domains binding to specific proline-rich peptide motifs.

26 tal anionic groups linked by self-assembling peptide motifs.

27 formed between structured domains and short peptide motifs.

28 compact interaction modules, referred to as peptide motifs.

29 dular domains each interacting with multiple peptide motifs.

30 cing, we discovered unique USP11-interacting peptide motifs.

31 evolutionary conservation of Vg-proteotypic peptide motifs.

32 ons, were found to share largely overlapping peptide motifs.

33 responsible for their emergence from simple peptide motifs.

34 t the CRD and guide selection of synergistic peptide motifs adjacent to the CRD.

35 The two distinct peptide motifs adopt markedly different bound conformati

36 Asp(330) exposed a novel p10 NH(2)-terminal peptide motif (AISS) that retained the ability to mediat

37 The chemical versatility of the peptoid-peptide motif allows low-molecular-weight drugs to be pr

38 h foldable sequence-space between the simple peptide motif and extant protein fold is demonstrated.

39 nine residues, given the lack of a consensus peptide motif and the proximity of O-glycosites.

40 he specific sequence of a given TNKS-binding peptide motif and the quaternary structure of individual

41 es the utility of the approach to predicting peptide motifs and individual residues important for the

42 the potential utility of myriad other short peptide motifs and provide a blueprint for therapeutic a

43 By analyzing selected cell-homing peptide motifs and their NCI-60 recognition patterns, we

44 novel leucine-rich sequence or an undefined peptide motif, and both appear to act through CRM1-indep

45 et binds E2F, the A/B pocket binds the LXCXE peptide motif, and the C pocket binds the nuclear c-Abl

46 re screened for H-2b allele-specific class I peptide motifs, and four peptides (PA11, PA12, PA13, and

47 The same peptide motifs are contained in pathogenic microorganism

48 These peptide motifs are not only conserved among the TCF fami

49 While this staggering number suggests that peptide motifs are numerous and the most understudied fu

50 ent work demonstrates that chromatin-derived peptide motifs are portable and in some cases can be cus

51 ich contain COOH-terminal PDZ domain binding peptide motifs, are found colocalized at high density at

52 Arginine-rich peptide motifs (ARMs) capable of binding unique RNA stru

53 ubstitutions defined the critical amino acid peptide motif as RRKQXK-PXXF.

54 of the discovery of phosphoserine/threonine peptide motifs as binding targets of the polo box domain

55 - blocking peptides yielded phage with a new peptide motif (Asn-Pro-Phe) that also bound specifically

56 icity to bone by grafting the bone-targeting peptide motif (AspSerSer)(6) onto the AAV9-VP2 capsid pr

57 owth regulators able to bind both glycan and peptide motifs at intra- and extracellular sites.

58 The crystal structure of this peptide motif bound to vinculin D1 shows that the two he

59 cts with the N332gp120 glycan and gp120 GDIR peptide motif, but in a distinct Env-binding orientation

60 tapeptides, based on our previously reported peptide motif c(-phg-isoDGR-X-), in which high activity

61 ains three copies of a conserved DNA-binding peptide motif called the 'AT-hook' that preferentially b

62 orylation site but also by binding to linear-peptide motifs called docking sites.

63 and computational analysis, that a truncated peptide motif can engage the two anomers of an isolated

64 Surprisingly small peptide motifs can confer critical biological functions.

65 s utilized to successfully identify a simple peptide motif capable of recapitulating, via gene duplic

66 lpha-helical coiled-coil to generate modular peptide motifs capable of assembling into metalloporphyr

67 gnition complex through its PCNA-interacting peptide motif, causing accumulation of MMR intermediates

68 o the DNA template by interacting with short peptide motifs conserved in a variety of sequence-specif

69 The results showed that: (a) minimal signal peptide motifs consisting of charged N, hydrophobic H, a

70 II beta-turn that serves to place the entire peptide motif, consisting of ThrP5, ProP6, TrpP8, MetP9

71 hanistic models that describe how reiterated peptide motifs could synergistically effect transcriptio

72 A peptide motif [CS][CS]-x(0,2)-G-x(1)-C-x(2,3)-S-x(3)-L f

73 evidenced by their requirement for specific peptide motifs, cytoskeletal elements, and motor protein

74 Here we show that a phosphorylated peptide motif derived from human papillomavirus 8 (HPV-8

75 Three peptide motifs differentiate the POGase existing in phyl

76 we identified two OmpG nanopores with unique peptide motifs displayed in either loop 3 or 6, which al

77 in a shallow groove formed by the conserved peptide motif E ... H ... SXWY ... G, with additional st

78 mbrane-associated adaptors, which have short peptide motifs, either the clathrin-box (CBM) and/or the

79 dia proteins and tagged them with a multiple peptide motif element called F8M4.

80 Peptide motifs embedded within intrinsically disordered

81 rizations, we discovered a strongly enriched peptide motif, employed by the Int-D to facilitate speci

82 ate complexes are bound to PRMT5 through two peptide motifs, enabling these adaptors to act as flexib

83 ucture drives Grp94 recognition, rather than peptide motifs exposed by unfolded protein.

84 hat mouse Fpr3 (Fpr-rs1) recognizes the core peptide motif f-MKKFRW that is predominantly present in

85 The LXCXE peptide motif facilitates interaction between the RB tum

86 Most PDZ domains recognize specific peptide motifs followed by a required COOH-terminus.

87 om only 4 viral genes, nearly all having the peptide motif for BL2*02, the dominantly expressed class

88 To identify peptide motifs for FAP-selective inhibitor design, we us

89 on system and immunopeptidomics to determine peptide motifs for the 2 class II molecules expressed by

90 enced the erg6 cDNA, identified the putative peptide motifs for the sterol and SAM binding sites in t

91 tructure of human Pds5B bound to a conserved peptide motif found in both Wapl and Sororin.

92 terminal half of which contains a mixture of peptide motifs found in alpha-, beta-, and gamma-tubulin

93 (KLC(TPR)), they can recognize short linear peptide motifs found in many cargo proteins characterize

94 its kinesin-1 interactions with short linear peptide motifs found in organelle-specific cargo adaptor

95 Adaptor protein interaction with specific peptide motifs found within the intracellular, carboxyl

96 his study shows that a short linear EEIWVLRK peptide motif from Caskin1 is necessary and sufficient f

97 t bears a dual role in sensing the conserved peptide motif from phytocytokines and microbial proteins

98 The data suggest that peptide motifs from at least three regions of the N-term

99 The selection of distinct peptide motifs from identical libraries confirmed that m

100 crystallography, we show that FxDxF and WVxF peptide motifs from synaptojanin bind to distinct subdom

101 neutrophil-binding phage displaying a novel peptide motif, GPNLTGRW.

102 meric immunogens as carriers for recombinant peptide motif grafting.

103 sin comprises two phylogenetically conserved peptide motifs, [GS]LFXG[ML]X[LV] and S[AV]F[SA]FLN, wit

104 A peptide motif, GXXX(D/E)(R/K)XG(R/K)(R/K), has been cons

105 activity, and a synthetic acidic-hydrophobic peptide motif had large-scale chromatin decondensation a

106 Liposomes with peptide motifs have been successfully used in glioma-tar

107 These essential peptide motifs have now been shown to function by access

108 Liposomes with peptides motifs have been widely applied for targeted de

109 age displaying trinitrotoluene (TNT)-binding peptide motifs identified from a phage display selective

110 AuNCs toward S. aureus and MRSA, the binding peptide motifs identified from HSA-AuNCs were characteri

111 ecific mutants, we identified a novel, short peptide motif immediately C-terminal to the signal seque

112 R41-PQLC2 interaction is mediated by a short peptide motif in a flexible loop that extends from the W

113 The peptide motif in MeCP2 that binds to TBL1/TBLR1 is essen

114 Although a short conserved peptide motif in Sall1 is sufficient to recruit NuRD, it

115 We demonstrate here that a peptide motif in the C terminus of the HTLV-1 nucleocaps

116 f mitotic phenotypes identifies a novel KLTF peptide motif in the Cik1 N-terminus.

117 substitution mutants, we identified a short peptide motif in the cytoplasmic C-terminal region of EA

118 ex contacts, including a calcineurin-binding peptide motif in the disordered tail of FAM126A, which w

119 ated that this domain binds to both the NPXY peptide motif in the lipoprotein receptor tails as well

120 with clathrin through one or two copies of a peptide motif in the p6 domain of Gag that resembles the

121 tween the human G3BP1/2 proteins and an OxFG peptide motif in the SARS-CoV-2 nucleocapsid (N) protein

122 (HIV-1) and other retroviruses harbor short peptide motifs in Gag that promote the release of infect

123 well established that retroviruses use short peptide motifs in Gag, known as late domains, to usurp c

124 the IRS proteins may ordinarily bind acidic peptide motifs in membrane proteins or other acidic memb

125 The presence of related peptide motifs in other transcription factors indicates

126 des (RiPPs) originating from repetitive core peptide motifs in precursor peptides with plant-specific

127 nzymatic intermolecular modification of core peptide motifs in precursor peptides.

128 sion that involves competition between short peptide motifs in repressor and activator proteins for i

129 DZ domains accomplish by binding to specific peptide motifs in target proteins.

130 Mutational disruption of each of five LXXLL peptide motifs in the beta-catenin armadillo repeats did

131 lved in endosomal protein sorting, and short peptide motifs in the HIV-1 Gag late domain and Ebola vi

132 t there might be over a million instances of peptide motifs in the human proteome.

133 to known Stat3-binding phosphotyrosine (pY) peptide motifs, including those of the epidermal growth

134 r for E2F-responsive elements, and an RGD-4C peptide motif inserted into the adenoviral fiber to enha

135 become a valuable approach to develop linear peptide motifs into metabolically stable and potentially

136 ficile by the sortase SrtB and that an SPKTG peptide motif is involved in the transpeptidation reacti

137 Interestingly, this peptide motif is sequestered within the known ASF1-H3-H4

138 Single peptide motifs joined by a flexible amino acid linker in

139 iral structural protein, Gag, contains small peptide motifs known as late domains that promote effici

140 proteins containing the abundant endothelial peptide motifs led to a nearly 100-fold increase of surf

141 We evaluated several cyclic peptide motifs linked by ester bonds between the P2 and

142 ) of NHERF specifically binds to an internal peptide motif located within the COOH-terminal regulator

143 tudies reveal that multiple degenerate short peptide motifs located within the RGG domain of Npl3p se

144 L epitope prediction that relies on dominant peptide motifs may not always identify the correct epito

145 ve identified a short evolutionary conserved peptide motif named SADH motif (SCRIB ABLIMs DMTN Homolo

146 xport can be determined by positively acting peptide motifs, namely, NESs, and suggest that Rev prote

147 Similarly, this same synthetic peptide motif of HIP could block about 50% of [3H]HP bin

148 to a heparan sulfate (HS)-binding synthetic peptide motif of HIP in a HP-inhibitable fashion.

149 control by binding the C-terminal (M/I)EEVD peptide motif of Hsp/c70(90) with its N-terminal tetratr

150 e neuropilin-binding RXXK tissue-penetration peptide motif of iRGD.

151 d this by analyzing the function of the ;QA' peptide motif of the Hox protein Ultrabithorax (Ubx), a

152 Two copies of a mutant peptide motif of VP16 (viral protein 16) possess large-s

153 Three peptide motifs of cMyBPC were identified as the potentia

154 ibodies in human sera that recognize allelic peptide motifs of distinct parasite types.

155 Peptide motifs of HLA-C unveil anchors in position 2 or

156 approach was developed in order to identify peptide motifs of interest based on clustering and contr

157 a tool to elucidate the specific function of peptide motifs of proteins.

158 block copolymers (SELPs) (composed of repeat peptide motifs of silk and elastin) differed from ELPs i

159 , SM proteins bind the N-terminal peptide (N-peptide) motif of the SNARE subunit syntaxin, but the fu

160 ferred to a protein by the presentation of a peptide motif on a surface loop.

161 nt (PIF) pocket--is engaged by an activating peptide motif on downstream substrate kinases (PIFtides)

162 recycling in a manner that is dependent on a peptide motif on the cytoplasmic domain.

163 xes through their ability to recognize short peptide motifs on other proteins.

164 hereby MDM2 binding to at least two distinct peptide motifs on p53 promotes ubiquitination.

165 nique for selectively recognizing glycan and peptide motifs on the surface of red blood cells.

166 ittle is known about the functional domains, peptide motifs, or residues of any Vif protein.

167 nhances the subsequent binding of additional peptide motifs; or 3) a high-affinity interaction betwee

168 ernative way to obtain the whole class I MHC peptide motif, particularly when a specific antibody is

169 sequence, yet a lysine-rich 12-14-amino acid peptide motif (pentalysine cluster), which is conserved

170 We identified canonical peptide motifs per HLA allele, unique and shared binding

171 dditive contributions of activity-regulating peptide motifs play important roles in moderating the ph

172 Here we show that a repeated peptide motif present in both SMRT and NCoR is sufficien

173 aromyces cerevisiae gene YRB1 and contains a peptide motif present in several proteins found within t

174 TransMoDEs are derived from Angiopep-2, a peptide motif previously employed as a covalent tag to f

175 Tyrosine 204 resides in a peptide motif previously thought to be involved in AdoMe

176 IV from the plasma membrane requires a small peptide motif, Pro-Thr/Ser-Ala-Pro (PTAP), located near

177 (SH2) domain with phosphotyrosine-containing peptide motifs (pTyr), are ubiquitous and important to m

178 at sequence-dependent glycosylation of small peptide motifs results in glycomodules.

179 Here we observed the presence of a tri-peptide motif, RGD, in domain 6 of the human CDH17 seque

180 s transmembrane domain(s) or signal sequence peptide motif(s) suggests that Tub is an intracellular p

181 tides having a motif almost identical to the peptide motif selected by 2H1.

182 We used in vivo phage display to isolate a peptide motif (sequence CKGGRAKDC) that homes to white f

183 phage display peptide library, we isolated a peptide motif, sequence Phe-Phe/Tyr-Any-Leu-Arg-Ser (F(F

184 vector representations, or an embedding, of peptide motif sequences, and we compare our novel embedd

185 Natural biopolymers, such as peptide motif sequences, can be used as a template to di

186 synergistically effect transcription: 1) the peptide motifs simultaneously bind to quasi-identical si

187 haracterized and revealed a highly conserved peptide motif sufficient to inhibit TCR-mediated signali

188 A conserved peptide motif, T1, within the DT transmembrane helix 1 m

189 nts were performed to compare the avidity of peptide motifs, tandemly repeated two or four times, and

190 ARCs recognise a conserved tankyrase-binding peptide motif (TBM).

191 epressors, which bind to TLX via a conserved peptide motif termed the Atro box.

192 AAVP-TNF particles displaying the octreotide peptide motif (termed Oct-AAVP-TNF) were confirmed in vi

193 eractions through the binding of a conserved peptide motif, termed PAM2.

194 analysis of the features of this turn-helix peptide motif that are necessary for IGFBP-1 binding and

195 Moreover, this work uncovers a new peptide motif that binds to and inhibits intracellular a

196 Zalpha is a peptide motif that binds to Z-DNA with high affinity.

197 esulfonamides and that also includes the RGD peptide motif that can bind to cell-surface integrin adh

198 two zinc fingers (ZFs) consisting of a CCHC peptide motif that coordinates Zn(II).

199 Here, we show that a new peptide motif that emerged from such combinatorial scree

200 oteins, possesses a well-characterized LXCXE peptide motif that interacts with the pocket domain of p

201 p codons on full-length mRNA using a nascent peptide motif that interferes with translation terminati

202 nds tightly to Vps45p via a short N-terminal peptide motif that is absent in Pep12p.

203 Thus, SurA recognizes a peptide motif that is characteristic of integral outer m

204 The eib sequences predict a C-terminal peptide motif that is characteristic of outer membrane p

205 ce analysis shows that P267 is embedded in a peptide motif that is conserved among the Trm5 family, b

206 These catalysts are based on a DXaa-DXaa peptide motif that is known to target the teicoplanin st

207 amino acid residues and a minimal fusogenic peptide motif that is necessary for promoting cell-cell

208 extracellular proteoglycan carrying a short peptide motif that is required for binding to Lrp4 recep

209 In addition, we have identified a conserved peptide motif that is required for this interaction.

210 d by a tripeptide in the V2 loop of gp120, a peptide motif that mimics structures presented by the na

211 Recent studies identified a short peptide motif that serves as a docking site for cyclin/c

212 mals, like pathogenic bacteria, have evolved peptide motifs that allosterically activate N-WASP, lead

213 ymes of halophilic organisms contain unusual peptide motifs that are absent from their mesophilic cou

214 Short linear peptide motifs that are intracellular ligands of folded

215 activator subdomains and acidic-hydrophobic peptide motifs that are responsible for transcriptional

216 s mediated by a novel type of 'dual-purpose' peptide motifs that can contact two different surfaces o

217 elicited by phosphate were clustered in the peptide motifs that comprise the active site.

218 hat lead to Taxol resistance-we selected for peptide motifs that confer resistance to Taxol-induced c

219 Hox protein evolution, and that pleiotropic peptide motifs that contribute quantitatively to several

220 from >1,000 peptides, we characterized novel peptide motifs that include dominant anchor residues ext

221 ing-phage random peptide library selects for peptide motifs that localize to different intracellular

222 that PDZ domains can recognize some internal peptide motifs that occur within a specific secondary st

223 omain of HIV-1 Gag contains highly conserved peptide motifs that recruit host machinery to sites of v

224 root leucoplasts and identified two transit-peptide motifs that specifically enhance preprotein impo

225 ichia coli, we identified additional nascent peptide motifs that stall ribosomes.

226 Zinc fingers are small DNA-binding peptide motifs that were discovered in this laboratory.

227 On the basis of this peptide motif, the present study aimed at identifying th

228 NA, with the conserved PIP (PCNA interacting peptide)-motif, the unique P-domain, and the thumb domai

229 nce for the membrane compartmentalization of peptide motifs thought to target to lipid rafts.

230 T-Ag and E1A each contains an LXCXE-peptide motif through which binding to the conserved 'A/

231 mbly of signaling complexes by binding short peptide motifs through a distinctive safety-belt mechani

232 tylproteins was used to identify a potential peptide motif, TMDX1-12AAC(C)A (TMD, transmembrane domai

233 me with an M13KE phage that delivers a small peptide motif to an F(+), alpha-complementing strain of

234 ruses exploit a capsid-associated small PPxY peptide motif to manipulate the autophagic machinery to

235 beta4GalNAc-T4 are able to utilize the same peptide motif to selectively add GalNAc to beta1,6-linke

236 Conjugation of beta-sheet peptide motif to the CHP results in self-assembly of non

237 conserved H(abc) domain, which connects an N-peptide motif to the SNARE core domain and is thought to

238 for ClpX, in that both proteins use related peptide motifs to bind to the N-terminal domain of ClpX,

239 eceptors based on similarity of the selected peptide motifs to mouse proteins.

240 ing (VPS) pathway to bud from cells, and use peptide motifs to recruit specific class E VPS factors.

241 all intrinsically disordered or unstructured peptide motifs to regulate the specific activity of a pr

242 ent an approach for the efficient docking of peptide motifs to their free receptor structures.

243 Here, we identified a peptide motif, TPKTSVT, that homes to the yolk sac, indu

244 In addition to peptide motifs, ubiquitination of cytosolic lysine resid

245 peptide display and one ZIP kinase consensus peptide motif was identified in p21(WAF1).

246 Ralpha ligand-binding domain and coactivator peptide motifs was comparable to PPARalpha agonists, but

247 Although interactions with the consensus peptide motif were conserved in all structures, flanking

248 of four CAMHC peptides containing the -KXXS- peptide motif were found to be immunogenic.

249 Specific substitutions within the 3S peptide motif were prepared by directed mutagenesis.

250 Antibody binding peptide motifs were identified from 28 Chagas repertoire

251 Different peptide motifs were recovered from each of these tissues

252 me sequence showed that these EF-P-dependent peptide motifs were represented in flagellar genes.

253 ar receptors preferentially bind to an LXXLL peptide motif which is highly conserved throughout the 3

254 in containing the C-terminal Asp-Pro nascent peptide motif (which interferes with translation termina

255 selective evolutionary retention of transit-peptide motifs, which enhances import into specific plas

256 inding pocket of COP1 via two valine-proline peptide motifs, which represent a known interaction moti

257 We designed and screened minimal peptide motifs whose conjugates with polyethylene glycol

258 vivo B. subtilis reporter system identified peptide motifs whose efficient synthesis was most depend

259 ubiquitin-interacting motif (UIM) is a short peptide motif with the dual function of binding ubiquiti

260 R)-fold, a module that typically binds short peptide motifs, with three TPR alpha-helical repeats.

261 between the KLC2(TPR) domain and a conserved peptide motif within an unstructured region of the molec

262 lex in vivo Previously we identified a short peptide motif within H3 that binds to the TPR domain of

263 racts with alphabeta-tubulin through a small peptide motif within its MT-binding domain.

264 ing mutational analysis, we show that a WRPW peptide motif within the Otx2 protein is required for ph

265 bunit to specific phosphotyrosine-containing peptide motifs within activated cytoplasmic receptor dom

266 g 793 plant transcriptomes for moroidin core peptide motifs within BURP-domain precursor peptides, we

267 eparase recognizes and cleaves two conserved peptide motifs within Scc1.

268 de microarray screening of C3 identified two peptide motifs within the beta chain of fibrinogen (resi

269 elimits residues within two highly conserved peptide motifs within the tail that are required (KKCRAR

270 ese activators, and short acidic-hydrophobic peptide motifs within these subdomains.

271 mediated by seven conserved diaromatic penta-peptide motifs (WXXX(F/Y) motifs) in the N-terminal half