ライフサイエンスコーパス: peptide sequence

1 on, regardless of the residues' location and peptide sequence.

2 d by the positions of the amino acids in the peptide sequence.

3 distribution of cationic residues along the peptide sequence.

4 on of hMSC cultures compared with the native peptide sequence.

5 structures from operon content and precursor peptide sequence.

6 s, yet remarkably tolerant to changes in the peptide sequence.

7 ures of the resultant assemblies through the peptide sequence.

8 nformative with respect to glycosylation and peptide sequence.

9 f transient nanostructures controlled by the peptide sequence.

10 our orders of magnitude within each distinct peptide sequence.

11 activate caspase-3 enzyme to cleave the DEVD peptide sequence.

12 tides bearing opposite charge and varying in peptide sequence.

13 ide chains and was influenced by the primary peptide sequence.

14 adjacent to threonine or iso-threonine in a peptide sequence.

15 odified by insertion of a protease cleavable peptide sequence.

16 heir nature, quantity, and position within a peptide sequence.

17 depends on long-range interactions within a peptide sequence.

18 These rules can be generalized for other peptide sequences.

19 rofiles to the list motifs formed by similar peptide sequences.

20 sing 14-3-3 proteins with the target partner peptide sequences.

21 aging-an approach that is applicable to most peptide sequences.

22 y can also give additional confidence on the peptide sequences.

23 hest antioxidant activity contained 15 novel peptide sequences.

24 stinal tract and may contain novel bioactive peptide sequences.

25 with high antioxidant properties and unique peptide sequences.

26 CB[8] (MVCB[8]) within a vast pool of cyclic peptide sequences.

27 s a general detector of membrane activity in peptide sequences.

28 he presence of the MMP cleavage sites in the peptide sequences.

29 e to recognize and process a vast variety of peptide sequences.

30 nd acetylated peptides to generate 12 larger peptide sequences.

31 tial tri-disulfide peptide (STP) toxins from peptide sequences.

32 ta-strands, helices, reverse turns) in short peptide sequences.

33 ducing conformational constraints into small peptide sequences.

34 viral peptide sequences and T1D autoantigen peptide sequences.

35 itories have few well-annotated virus mature peptide sequences.

36 backbone and nonbackbone ions) directly from peptide sequences.

37 LC and then analyzed by LC-MS/MS to identify peptide sequences.

38 ted monoclonal phages revealed two conserved peptide sequences.

39 amino acid residues, in known antimicrobial peptide sequences.

40 low for high-throughput and accurate de novo peptide sequencing.

41 -energy dissociation (HCD) fragmentation for peptide sequencing.

42 let photodissociation (UVPD) was applied for peptide sequencing.

43 s (11%-49%), peptide analytes (10%-16%), and peptide sequences (3%-10%) compared to data derived from

44 monomer of the MGAT2 enzyme predicted by its peptide sequence, a 76-kDa moiety was detected in SDS-PA

45 Peptide sequencing after MS/MS fragmentation enabled the

46 Alternatively, de novo peptide sequencing algorithms annotate MS/MS spectra and

47 generation for any organism on the basis of peptide sequence alone.

48 Amongst the 4 cationic peptides, the peptide sequence ALPMHIR, identified as lactokinin and k

49 Proteomics peptide sequencing analysis indicated large peptide sequ

50 ) was identified, supported through in-depth peptide sequencing analysis, and found to carry mitochon

51 germline alterations change the neoantigenic peptide sequence and also affect neoantigen binding pred

52 HLA class I ligands is modulated by both the peptide sequence and conformation, as determined by the

53 c limitations of VIP, we modified the native peptide sequence and generated two stable synthetic anal

54 e-like activity significantly depends on the peptide sequence and length.

55 er proximal (nearby) variants that alter the peptide sequence and may influence neoantigen binding.

56 M(2)R selectivity was dependent on the peptide sequence and on the type of linker.

57 e a multimodal distribution knowing only the peptide sequence and peak intensities from mass spectrom

58 lian membranes by systematically varying the peptide sequence and salt concentration.

59 plex, may be amenable for inhibition and the peptide sequence and structure derived from the interact

60 n mobility mass spectrometer for analysis of peptide sequence and structure showing ultraviolet photo

61 and deep-sequenced to identify the enriched peptide sequence and the accompanying cPTM simultaneousl

62 to identify as they lack discernable signal peptide sequences and can make use of diverse secretion

63 identification platform (MAGIC) to identify peptide sequences and glycan compositions directly from

64 Identifying peptide sequences and receptors involved in hormonal sec

65 re that generates large virtual libraries of peptide sequences and searches within the resulting inte

66 gers of T1D given similarities between viral peptide sequences and T1D autoantigen peptide sequences.

67 l DNA and RNA sequencing with serum antibody peptide sequencing and antibody synthesis, rare circulat

68 example proteins (up to 272 kDa) by de novo peptide sequencing and illustrate the advantages of this

69 tructures lags far behind similar efforts in peptide sequencing and proteomics.

70 We confirmed IRES activity by both peptide sequencing and ribosome profiling in muscle from

71 isoforms have a conserved N-terminus (signal peptide sequence) and are dissimilar in amino acid seque

72 omatic component, (ii) linker segment, (iii) peptide sequence, and (iv) C-terminus.

73 is an uncharacterized protein with a signal peptide sequence, and the third is an ortholog of a Glob

74 MS/MS spectra, ignoring unexpected glycan or peptide sequences, and making incorrect assignments beca

75 rbitrap mass spectrometer with HCD-MS/MS for peptide sequencing, and MaxQuant bioinformatics tool for

76 ning an alternate and non-protease-cleavable peptide sequence are stable in both in vitro and in vivo

77 engines or quantitative tools as input, the peptide sequences are aligned to an internal protein dat

78 Intriguingly, many of the new peptide sequences are attributable to antibody variable

79 Because the peptide sequences are completely random, the assay is ef

80 Peptide sequences are known to recognize and bind differ

81 Nearly half of peptide sequences are unique to the reporting laboratory

82 ycopeptides, with the glycan attached to the peptide sequence, are characterized by tandem mass spect

83 why so many large proteins, without a signal peptide sequence, are present in the prostatic fluid.

84 Using the consensus substrate-peptide sequence as a starting point, we optimized the l

85 erties of the glycopeptides depending on the peptide sequence as well as the size and charges of the

86 te reveals great potential for DEAdcCE-caged peptide sequences as selective drug carriers in the cont

87 ered the underlying grammar of antimicrobial peptide sequences, as demonstrated by the experimentally

88 ear magnetic resonance and mass spectrometry peptide sequencing assays with the La antigen protein de

89 e fragment ions to improve the confidence of peptide sequence assignment in proteomic analyses and ex

90 proteomics search engines such as Comet for peptide sequence assignment, greatly simplifying data an

91 processing was performed to obtain confident peptide sequence assignments, allowing the detection of

92 This transition depends on nascent peptide sequence at specific tunnel locations.

93 53 that has a glutamic acid-rich amphipathic peptide sequence attached to N-terminal of bZIP53 leucin

94 rate feasibility, we have (i) generated 1536 peptide sequences based on the parallel dimeric coiled-c

95 We describe a strategy for de novo peptide sequencing based on matched pairs of tandem mass

96 The identical peptide sequence bearing an amide terminus did not bind

97 Thus, the amphipathic peptide sequences become available to disrupt the endoso

98 e binding was observed in the Trp-containing peptide sequence but not the other tested sequences.

99 lden color upon the cleavage of the specific peptide sequence by the Listeria protease.

100 e proteins and obtained 43 de novo-generated peptide sequences by tandem MS.

101 approach this fundamental question, we used peptide sequencing by high-resolution mass spectrometry

102 De novo peptide sequencing by mass spectrometry represents an im

103 In this work, we demonstrate that peptide sequence can be programmed to direct the structu

104 of this method resides in the fact that the peptide sequence can be used to identify the microbial s

105 nge of oligomers that a single amyloidogenic peptide sequence can form, but also how mutation can alt

106 hydrolytic stability of functional, natural peptide sequences can be improved by two orders of magni

107 to predict tandem mass (MS/MS) spectra from peptide sequences can significantly enhance our understa

108 Here, we describe a short peptide (sequence CAQK) identified by in vivo phage disp

109 The marker peptide sequences chosen were those found to be present

110 Alanine scanning of the peptide sequence, combined with preliminary in silico mo

111 demonstrate that a carboxyl-terminated RXXR peptide sequence, conjugated to liposomes at a concentra

112 Hyp of model substrate acceptors having AGP peptide sequences, consisting of non-contiguous Hyp resi

113 Due to the enormously large number of peptide sequences contained in global peptide profiles g

114 we have designed and tested a number of new peptide sequences containing the key CxC or CxxC motifs.

115 s of growing interest, particularly as short peptide sequences continue to play important roles as bi

116 has proteolytic activity selective against a peptide sequence corresponding to the viral VP1-2A polyp

117 functions as a viral protease that cleaves a peptide sequence corresponding to the VP1-2A polyprotein

118 ment ions in AI-ETD+ substantially increases peptide sequence coverage while also improving peptide i

119 med within approximately 60 s, yielding 100% peptide sequence coverage.

120 A 19-mer peptide sequence covering the core of the immunodominant

121 urther truncates of PaaP leader and follower peptide sequences demonstrate the different impacts of t

122 Examination of peptide sequence dependence of this amidine conjugation

123 ophages in a time-, dose-, temperature-, and peptide sequence-dependent endocytotic process.

124 we have investigated the effect of a shorter peptide sequence derived from Cpn 60.1, named IRL201104,

125 ILA1 CD8(+) T-cell clone that responds to a peptide sequence derived from human telomerase reverse t

126 show that p12 proteins engineered to encode peptide sequences derived from known viral tethering pro

127 Peptide sequences derived from the well-defined CARM1 su

128 This stapling modification performed on a peptide sequence designed to bind the C-terminal domain

129 d hydrophilic (such as Lys) side-chains in a peptide sequence determines the orientation of the pepti

130 ific for AGPs because substrates lacking AGP peptide sequences did not act as acceptors.

131 Replacement of this linker with flexible peptide sequences did not restore DhNik1p activity.

132 er of the oppositely charged residues in the peptide sequence differ, such that they have different c

133 ared with the adult stage for which specific peptide sequences dominated.

134 SILAC partner spacing and filters candidate peptide sequences during a database search using this in

135 d 972 bp, respectively and the corresponding peptide sequences each contained several conserved motif

136 d strategy provides high-performance de novo peptide sequencing, enabling the de novo sequencing of t

137 in a sequence-dependent manner, resulting in peptide sequence-encoded properties such as UV absorbanc

138 The peptide sequences encompassed specific residues where mu

139 riteria that were used to select the mutated peptide sequences, evaluate the parameters that characte

140 clear analogue conjugated to an octaarginine peptide sequence exhibited some cytotoxicity over 24 h,

141 at secondary structure is the most important peptide sequence feature for predicting AVPs.

142 Polymers displayed a GKRK peptide sequence for targeting p32, a protein often over

143 synthetic polymeric substrates containing a peptide sequence for that MMP.

144 The inhibitors are based on a characteristic peptide sequence for the inhibition of the cysteine prot

145 yet extensive survey of key short bioactive peptide sequences for a range of applications ranging fr

146 tracts are used to directly identify optimal peptide sequences for probe design.

147 thesis, we studied simple positively charged peptide sequences for the occurrence of typical MAP-like

148 l imaging because of the high specificity of peptide sequences for their biomolecular targets.

149 In tests on 1271 peptide sequences for which the experimental dissociatio

150 D-IM-MS analysis serves both as a method for peptide sequencing for peptides of similar (or identical

151 ld be identified in addition to 33854 unique peptide sequences found.

152 e of the Brd4 ET domain bound to a conserved peptide sequence from the C terminus of murine leukemia

153 teractions, we show using a newly identified peptide sequence from the Clr3 histone deacetylase and a

154 N-linked carbohydrate is to shield conserved peptide sequences from recognition by humoral immunity.

155 blies in nature are dimeric, we select short peptide sequences from the interface of a heterodimer of

156 -MS together to enable the identification of peptide sequence, glycosylation site and the structure o

157 is remarkable biointerface, several of these peptide sequences have found extensive use in creating f

158 or temporarily attaching highly solubilizing peptide sequences ("helping hands") onto insoluble pepti

159 al amino acid residue, which makes aliphatic peptide sequences highly vulnerable to NO(3)(*)-induced

160 s inserted at the N-terminus in a very short peptide sequence (i.e., PhCO-(R)-Oxo-Azn-L-Ala-Aib-L-Ala

161 were selected from approximately 64 million peptide sequences (i.e., a large unbiased representation

162 The 5B4 epitope corresponds to a peptide sequence (I56-K68) overlapping with the binding

163 To facilitate the subsequent peptide sequence identification by common database searc

164 TBLASTN analysis of the acquired peptide sequences identified a single full-length maize

165 arly cancer detection test based on a set of peptide sequences identified by comparing cancer patient

166 Human vaccine recipients responded to the peptide sequences identified by LC-MS/MS.

167 Based on the peptide sequences identified by mass spectrometry, 30 pr

168 DPP-IV inhibitory peptide sequences identified within camel and bovine mil

169 xcess of enzymatic cleavage sites, nonunique peptide sequences, impaired peptide ionization/separatio

170 thyl-hexanoic acid, and linearization of the peptide sequence improves antibacterial activity and red

171 ues, which were artificially inserted into a peptide sequence in order to perform native chemical lig

172 Our findings underline a key role for peptide sequence in the ability to assemble and form tox

173 ficient identification of low molecular mass peptide sequences in food protein hydrolysates.

174 Inserting antigenic peptide sequences in introns that are spliced out before

175 creening technology to determine the precise peptide sequences in SARS-CoV-2 that are recognized by t

176 this pathway normally requires two signals: peptide sequences in unassembled outer-membrane proteins

177 Peptide sequences included in fractions with antioxidant

178 The identification of the peptide sequence incorporating the oxidised amino acid p

179 Binary encoding of peptide sequences into differential antimicrobial mechan

180 e combine several key strategies for de novo peptide sequencing into a single high-throughput pipelin

181 The peptide sequences investigated were functionalized with

182 The most abundant and frequent peptide sequence ions were a/x-type products which, impo

183 in both mouse and human cells even when the peptide sequence is not conserved.

184 omeric peptide oxidation products (where the peptide sequence is the same but isomeric oxidation prod

185 e)copper(II) and various organelle-targeting peptide sequences is reported.

186 hese proteins interact with PCNA via a short peptide sequence known as a PIP (PCNA interacting protei

187 mass distributions (AAMDs), the influence of peptide sequence length on parameter sensitivity, and ho

188 he transpeptidase Sortase A (SrtA) for short peptide sequences (LPXTG and GGG).

189 he effect of a cleavable leucine-rich signal peptide sequence (Lucy tag) on OR surface expression in

190 hinders the de novo prediction of the active peptide sequences, making MS-based measurements very val

191 A new peptide sequence (MB1) has been designed which, in the p

192 CP-1 micelles consisting of a CCR2-targeting peptide sequence (MCP-1 peptide) and the apoptotic KLAKL

193 Full Spin Analysis (HiFSA) to establish NMR peptide sequencing methodology that overcomes the intrin

194 rogels of P(MAA-co-NVP) crosslinked with the peptide sequence MMRRRKK were synthesized and tested in

195 We found a highly conserved peptide sequence motif for HLA-C*05:01-restricted activa

196 ort the application of isotopically labelled peptide sequence MSTKDFNLDLVSVSKKDSGASP(R) (without thio

197 tography-tandem mass spectrometry (LC-MS/MS) peptide sequencing (multiplex substrate profiling by mas

198 erivatives based on the metabolically stable peptide sequence NLys-Lys-Pro-Tyr-Tle-Leu suitable for P

199 We report the design of two collagen-mimetic peptide sequences, NSI and NSII, that self-assemble into

200 ull-length maize cDNA clone encoding all the peptide sequences obtained from the purified enzyme.

201 MALDI-TOF study showed a peptide sequence of AFCGGSLVNENKMHSAGHCYKSRIQV at the N-

202 We found that molecules with a peptide sequence of alternating hydrophobic and hydrophi

203 Two proteolytic sites within the GLP1 peptide sequence of dulaglutide were identified using th

204 ominant strategy of modifying the endogenous peptide sequence of ligands for peptide-binding GPCRs.

205 The signal peptide sequence of MBLs dictates their adaptability to

206 According to our in silico predictions, the peptide sequence of the exposed extracellular unstructur

207 An N-terminal hepta-peptide sequence of yeast prion protein Sup35 with the s

208 fect of tubulin carboxy-terminal tails using peptide sequences of alpha-, beta-, or detyrosinated alp

209 FN directly or indirectly, here we identify peptide sequences of growth factor-binding sites in FN.

210 00 centroid measurements for 430 proteolytic peptide sequences of the Fab fragment (~78 900 centroids

211 ge, and ~10 900 centroid measurements for 77 peptide sequences of the Fc fragment.

212 in the identification of nearly 300 mutated peptide sequences, of which ~50 were characterized by qu

213 of the peptide, indicating the influence of peptide sequence on KIR-HLA association.

214 LRRK2 kinase activity, combining a reported peptide sequence optimized for LRRK2 binding and an esta

215 to myristoylated peptides independent of the peptide sequence or the position of the myristoyl group.

216 Given a peptide sequence (or elemental formula) and charge state

217 e (M)/methionine sulfoxide (M-ox) within the peptide sequences (PEP(Au) = AYSSGAPPMPPF/PEP(Au)(M-ox)

218 atic interactions in the center of the Abeta peptide sequence play a crucial role in the three-dimens

219 ion of UHM domains by UHM ligand motif (ULM) peptide sequences plays important roles during early ste

220 er cell lines and also discovered unexpected peptide sequence polymorphisms (pSPs).

221 cale screening, resulting in vast amounts of peptide sequences, potentially containing information on

222 However, no recurrent neoantigen peptide sequences predicted responder patient population

223 dical (ABTS(+)) scavenging assay and de novo peptide sequencing produced two peptides, WAFAPA (661.32

224 We show that long peptide sequences, producing precursors with up to five

225 ly modified amino acid sequences to evaluate peptide sequence properties influencing binding to C. al

226 analyzed by MALDI mass spectrometry, and the peptide sequences read directly from the resulting spect

227 d peptide array libraries to investigate the peptide sequence recognition specificity of murine HEMK2

228 ad specificity the generation of overlapping peptide sequences reduces the number of identified prote

229 With that in mind, this work investigates peptide-sequence-related factors that influence curvatur

230 stems of disease-relevant mutant protein and peptide sequences relates to the IPOD and JUNQ patterns

231 The degree of hydrolysis reached and the peptide sequences released over time were evaluated.

232 Short peptide sequences represent emerging analytes in a varie

233 allation of interlocked dicarba bridges into peptide sequences requires the development of a regiosel

234 -D-Oxd-Tri-CO motif may be introduced in any peptide sequence requiring the presence of a stable beta

235 The annotated peptide sequences resulting from Nano LC Ultimate 3000 S

236 Proteolytic cleavage of the peptide sequence results in a shift in wavelength of the

237 ay combined with reengineering of the signal peptide sequence results in display levels 24-fold above

238 Variations of the peptide sequence revealed that the compact state involve

239 Crystallographic analysis of 35 different peptide sequences revealed a range of conformational sta

240 Protein/peptide sequencing revealed 1kDa peptides with the prese

241 by coating FDA-approved PLGA-PEG NP with the peptide sequence RGD, which binds with high affinity to

242 Peptide sequence scrambling during mass spectrometry-bas

243 ur results strongly support the mechanism of peptide sequence scrambling via b ion cyclization, and p

244 y to diagnose propagation-related TUPS among peptide sequences selected by phage display.

245 While the traditional peptide-sequencing service gradually vanishes from acade

246 he shells by fusion to a predicted targeting peptide sequence, setting the stage for the use of these

247 The peptide sequence shows no homology to any previously des

248 Even other peptide sequences, similar to epitope sequences only wit

249 SVM is used to search the undiscovered peptide sequence space and identify Pareto-optimal candi

250 Here we report a methodology that allows the peptide sequence space to be searched for self-assemblin

251 These tools, which enable the peptide sequence space to be searched for supramolecular

252 e a variant TEV protease with altered target peptide sequence specificities.

253 enzoic acid separately into an amyloidogenic peptide sequence, synthesized alpha/beta, alpha/gamma an

254 Tag-based methods extract peptide sequence tags from a tandem mass spectrum and us

255 tential utility offered by a high-throughput peptide sequencing technology.

256 sed medium, also includes a unique synthetic peptide sequence that acts as a traceable "code" to iden

257 e MDA-7 has a potential 28 amino acid signal peptide sequence that can target it for active secretion

258 iviral activity of a parainfluenza F-derived peptide sequence that inhibits both parainfluenza and Ni

259 ater elimination and the formation of larger peptide sequences that are characterized by subsequent i

260 Discriminative n-grams are short peptide sequences that are highly frequent in one class

261 A screen for N-terminal peptide sequences that can bind to Gid10 showed that sub

262 s, which in turn explains the large array of peptide sequences that can function as NESs.

263 Cell-penetrating peptides (CPPs) are short peptide sequences that can translocate across cellular p

264 reasing intermolecular cohesion using longer peptide sequences that form stable beta-sheets was found

265 We designed stable beta-peptide sequences that generated globally amphiphilic (G

266 of an iterative peptide library to identify peptide sequences that have the following two properties

267 When fused to a cargo carrying peptide sequence this BCL-3-derived peptide, but not a m

268 arise because of the inability of an altered peptide sequence to properly engage protein homeostasis

269 ter programs use a protein database to match peptide sequences to the observed spectra.

270 quid chromatography-tandem mass spectrometry peptide sequencing to identify binders from fully random

271 nal control of the self-organization of beta-peptides sequences to adopt regular secondary structures

272 Short bimodular peptide sequences undergo a programmed sequence of event

273 n between isomeric leucine and isoleucine in peptide sequencing utilizes multistage electron transfer

274 peptide sequencing analysis indicated large peptide sequence variation without specific clone expres

275 Clone A2, with peptide sequence VTPNDDTFDPFR, showed the best response

276 Consequently, the peptide sequence was obtained manually by ESI-MS spectra

277 the SCHOOL approach and the SARS-CoV fusion peptide sequence, we rationally designed a novel immunom

278 By recovering AMELY-specific peptide sequences, we also conclude that the H. antecess

279 Using rationally designed short peptide sequences, we determined that the charge type an

280 The identified peptide sequences were analysed for their structural con

281 Peptide sequences were assembled on solid-phase.

282 By using PEAKS studio, 511 peptide sequences were first shortlisted based on their

283 onmental cycling protocol, hundreds of proto-peptide sequences were formed over a mere 4 d of reactio

284 ified) identified by de novo only; 102 short peptide sequences were identified (with 12 modified ones

285 ed from MS/MS spectra of their own and their peptide sequences were identified by the MS(3) spectra o

286 Thirteen peptide sequences were identified following UPLC-ESI MS/

287 A number of novel PEP inhibitory peptide sequences were identified in this study, includi

288 A total of 11 peptides sequences were identified in the fractions eval

289 specific regions in the Amyloid beta (Abeta) peptide sequence where variations cause enhanced toxicit

290 eling was effective for determination of the peptide sequence, which could be used to provide informa

291 of these CEST effects were dependent on the peptide sequence, which demonstrated the sensitivity of

292 oxisomal matrix proteins is encoded by short peptide sequences, which have been characterized as pero

293 inhibition effect of EGCG is specific to the peptide sequence, while those of resveratrol and curcumi

294 uots: The first is digested with trypsin for peptide sequencing, while the second has its ratio of (1

295 The peptide sequence with the highest sensitivity and select

296 B. pseudomallei FliC contained several peptide sequences with ability to bind multiple HLA clas

297 Four peptide sequences with existing biochemical applications

298 by LC-ESI-MS/MS allowed identification of 8 peptide sequences with potential antioxidant properties.

299 interaction is shown to require only a short peptide sequence within the central domain of these bact

300 epitopes and maximizing the content of human peptide sequences without disrupting protein structure a