ライフサイエンスコーパス: peptide synthetase

1 f the termination module of the nonribosomal peptide synthetase.

2 tion pathway that is based on a nonribosomal peptide synthetase.

3 ree-subunit (TycABC), 10-module nonribosomal peptide synthetase.

4 ntermediates on a multimodular, nonribosomal peptide synthetase.

5 ame (HTS1) encoding a multifunctional cyclic peptide synthetase.

6 (CepA, CepB, and CepC) modular nonribosomal peptide synthetase.

7 ety of ansatrienin from shikimic acid, and a peptide synthetase.

8 s, in contrast to the monomeric nonribosomal peptide synthetases.

9 presents a novel substrate for non-ribosomal peptide synthetases.

10 hesized on ribosomes and not by nonribosomal peptide synthetases.

11 ynthesized wholly or in part by nonribosomal peptide synthetases.

12 chain activities within dimeric nonribosomal peptide synthetases.

13 genes, orbI and orbJ, encoding nonribosomal peptide synthetases.

14 etases, firefly luciferase, and nonribosomal peptide synthetases.

15 assembled by hybrid polyketide/nonribosomal peptide synthetases.

16 nylation domains of the modular nonribosomal peptide synthetases.

17 between monomers and dimers in nonribosomal peptide synthetases.

18 me A ligases, luciferases, and non-ribosomal peptide synthetases.

19 been less well characterized in nonribosomal peptide synthetases.

20 ation and thiolation domains of nonribosomal peptide synthetases.

21 ally similar to the present day nonribosomal peptide synthetases.

22 nsation domain found in certain nonribosomal peptide synthetases.

23 ld enable engineering of novel non-ribosomal peptide synthetases.

24 oach has been unprecedented for nonribosomal peptide synthetases.

25 ed by two large multifunctional enzymes, the peptide synthetases 1 and 2.

26 ere we report an unprecedented non-ribosomal peptide synthetase activity that both assembles a serine

27 airwise Southern hybridizations identified a peptide synthetase acyladenylation module conserved amon

28 the substrate specificities of nonribosomal peptide synthetase adenylation (A) domains from DNA sequ

29 ate specificity prediction for non-ribosomal peptide synthetase adenylation domains based on the new

30 s a large rotation compared to structures of peptide synthetase adenylation domains.

31 trate specificities of related non-ribosomal peptide synthetase adenylation enzymes.

32 e screened syn-BNPs inspired by nonribosomal peptide synthetases against microbial pathogens, and dis

33 imodular polyketide synthase, a nonribosomal peptide synthetase, along with enzymes responsible for t

34 f a gene, HTS1, that encodes a 570-kD cyclic peptide synthetase and is lacking in Tox2- isolates.

35 n unprecedented convergence of non-ribosomal peptide synthetase and polyketide synthase assembly-line

36 The hybrid nonribosomal peptide synthetase and polyketide synthase biosynthetic

37 DszC, with DszC containing both nonribosomal peptide synthetase and polyketide synthase modules.

38 exploring interactions between nonribosomal peptide synthetase and polyketide synthase modules.

39 e multidomain enzymes, known as nonribosomal peptide synthetases and polyketide synthases (NRPSs and

40 of natural products, including nonribosomal peptide synthetases and polyketide synthases.

41 ding of the structural cycle of nonribosomal peptide synthetases and provide insights into the produc

42 in part by enzymes resembling non-ribosomal peptide synthetases and that the ABC transporter ExiT is

43 at includes firefly luciferase, nonribosomal peptide synthetases, and acyl- and aryl-CoA synthetases/

44 own formally classified family, nonribosomal peptide synthetases, and several hybrid clusters.

45 is methodology to other dimeric nonribosomal peptide synthetases, and to the related fatty acid and p

46 Non-ribosomal peptide synthetases are giant enzymes composed of module

47 dular polyketide synthases and non-ribosomal peptide synthetases are molecular assembly lines that co

48 , encoding a peramine-producing nonribosomal peptide synthetase, as the central component.

49 hus, full reconstitution of the nonribosomal peptide synthetase assembly line by purified protein com

50 ay for this polyketide synthase/nonribosomal peptide synthetase assembly line.

51 of cyclic peptides inspired by nonribosomal peptide synthetase BGCs associated with the human microb

52 successfully expressed a 67-kb nonribosomal peptide synthetase biosynthetic gene cluster from the ma

53 modular polyketide synthase and nonribosomal peptide synthetase biosynthetic pathways are a rich sour

54 tekeeper adenylation domains of nonribosomal peptide synthetases can be switched from an alpha-amino

55 he organization of the deduced TxtA and TxtB peptide synthetase catalytic domains is consistent with

56 not previously associated with nonribosomal peptide synthetase chemistry.

57 We show that nonribosomal peptide synthetases ClbN and ClbB assemble and process a

58 biosynthesis of L-PAPA and the nonribosomal peptide synthetase CmlP.

59 We identified two peptide synthetase coding regions interrupted by a 10- t

60 is assembled by a four-subunit nonribosomal peptide synthetase complex, VibE, VibB, VibH, and VibF,

61 eparate carrier protein, and a non-ribosomal peptide synthetase condensation domain condenses it with

62 The nonribosomal peptide synthetase consisted of a priming module, six ex

63 tins are synthesized through a non-ribosomal peptide synthetase containing a terminal NAD(P)H-depende

64 in thioesterase domains of such nonribosomal peptide synthetases control the oligomerization and cycl

65 e carboxy terminus carrying the nonribosomal peptide synthetase cores, as well as the site-directed m

66 encoding proteins homologous to nonribosomal peptide synthetases, cytochrome P450-related oxidases, f

67 The pathway builds on a nonribosomal peptide synthetase de-rived di-tyrosine piperazine inter

68 is a polyketide synthase (PKS)-non-ribosomal peptide synthetase-derived natural product with potent a

69 marily polyketide synthase- and nonribosomal peptide synthetase-derived universe of microbial natural

70 he largest continuous bacterial nonribosomal peptide synthetase discovered so far is described.

71 ary metabolites synthesized by non-ribosomal peptide synthetases display diverse and complex topologi

72 od are demonstrated on a 37 kDa nonribosomal peptide synthetase domain subject to spectral overlap.

73 genes encoding for a six-module nonribosomal peptide synthetase EcdA, an acyl-AMP ligase EcdI, and ox

74 ide of 1,928 Da to an 18-module nonribosomal peptide synthetase encoded as a single gene in chromosom

75 e (2,3-DHB) and l-serine by the nonribosomal peptide synthetases EntB and EntF.

76 anine adenylation domain of the nonribosomal peptide synthetase enzyme gramicidin S synthetase A (Grs

77 odification of the product of a nonribosomal peptide synthetase enzyme, whose consequences are predic

78 heterocyclization ability in a nonribosomal peptide synthetase enzyme.

79 set of polyketide synthases and nonribosomal peptide synthetases evolve by concerted evolution, which

80 e whether CepA, a three-module 3,158-residue peptide synthetase expected to assemble the first three

81 se (PKS) subunits (fkbB, fkbC and fkbA), the peptide synthetase (fkbP), the 31-O-methyltransferase (f

82 ncluding the modular polyketide-nonribosomal peptide synthetase for necroxime assembly.

83 VbsS, a nonribosomal peptide synthetase free-standing module, then activates

84 identified, the non-canonical non-ribosomal peptide synthetase Fub8.

85 tified a 59-kb cryptic inactive nonribosomal peptide synthetase gene cluster proposed to be responsib

86 in, a major product of the gli non-ribosomal peptide synthetase gene cluster, is strongly associated

87 dicted lipopeptide encoded by a nonribosomal peptide synthetase gene cluster.

88 a widely distributed family of nonribosomal peptide synthetase gene clusters in gut bacteria.

89 cyclic peptides inspired by 96 nonribosomal peptide synthetase gene clusters were synthesized and sc

90 We have cloned a similar peptide synthetase gene from Neotyphodium lolii and inac

91 A peptide synthetase gene hypothesized to be important for

92 Each cosmid hybridized with one or more peptide synthetase gene probes and two also hybridized w

93 pregulate transcription of the non-ribosomal peptide synthetase gene required for nidulanin A biosynt

94 er of nine genes (including one nonribosomal peptide synthetase gene, ataP) that is required for acet

95 The complete nucleotide sequences of two peptide synthetase genes (txtAB) were determined from S.

96 ed portions of the acyladenylation module of peptide synthetase genes from genomic DNA of representat

97 ion of polyketide synthase and non-ribosomal peptide synthetase genes from two newly decoded genomes

98 We studied the non-ribosomal peptide synthetase genes involved in A21978C biosynthesi

99 Individual inactivation of the non-ribosomal peptide synthetase genes, xcnA and xcnK, and polyketide

100 gliP, the gene that encodes the nonribosomal peptide synthetase GliP.

101 sembly by polyketide synthases, nonribosomal peptide synthetases, glycosyltransferases and other enzy

102 A gene encoding a putative peptide synthetase has been cloned and partially sequenc

103 lar weight protein 2 (HMWP2), a nonribosomal peptide synthetase homologue, and YbtE in the initiation

104 Expression of all or parts of the peptide synthetase in Escherichia coli would facilitate

105 peptide and hybrid polyketide-non-ribosomal peptide synthetases, including those responsible for ass

106 ed using the recently described nonribosomal peptide synthetase independent siderophore (NIS) biosynt

107 for both siderophores involve a nonribosomal peptide synthetase independent siderophore (NIS) synthet

108 Here we uncover a nonribosomal peptide synthetase-independent biosynthetic pathway for

109 acyl carrier protein-dependent, nonribosomal peptide synthetase-independent biosynthetic system.

110 hizoferrin and encodes a single nonribosomal peptide synthetase-independent siderophore (NIS) synthet

111 a three-dimensional model of a nonribosomal peptide synthetase-independent siderophore (NIS) synthet

112 A non-ribosomal peptide synthetase-independent siderophore biosynthetic

113 AcsD and other members of the non-ribosomal peptide synthetase-independent siderophore superfamily m

114 a member of the superfamily of nonribosomal peptide synthetase-independent siderophore synthetases (

115 PMI0229-0239 encodes a non-ribosomal peptide synthetase-independent siderophore system for pr

116 respectively, which are highly homologous to peptide synthetases, indicating that exochelin biosynthe

117 esis of aminoacyl-thioesters by nonribosomal peptide synthetases is relaxed, whereas the amino acid s

118 NPS6, encoding a nonribosomal peptide synthetase, is a virulence determinant in the ma

119 ng hybrid PKS-PKS and PKS-NRPS (nonribosomal peptide synthetase) junctions and suggests fundamental g

120 t load carrier domains found in nonribosomal peptide synthetases, large molecule mass spectrometry is

121 quent enzymatic assays with the nonribosomal peptide synthetase-like AsbC, AsbD, and AsbE polypeptide

122 we discovered an unprecedented nonribosomal peptide synthetase-like-pteridine synthase hybrid biosyn

123 e is assembled from tyrosine by nonribosomal peptide synthetase logic.

124 ergopeptines requires the activities of two peptide synthetases, LPS1 and LPS2.

125 ng family of enzymes, including nonribosomal peptide synthetases, luciferase, and aryl- and acyl-CoA

126 er (siderophore) and product of nonribosomal peptide synthetase machinery, to the C-terminal serine r

127 ts loading module, which uses a nonribosomal peptide synthetase mechanism, and its initial elongation

128 dule (KS-AT-MT(2)-KR-ACP) and a nonribosomal peptide synthetase module (Cy(3)-MT(3)-PCP(3)-TE).

129 ical analysis of the N-terminal nonribosomal peptide synthetase module from the Thalassospira TtcA me

130 re, TxtB was identified as the non-ribosomal peptide synthetase module specific for 4-nitrotryptophan

131 Here we show that DdaD, a nonribosomal peptide synthetase module, activates and sequesters N(be

132 through the actions of CmaA, a non-ribosomal peptide synthetase module, and CmaE, an unusual acyltran

133 mposed of a loading module, one nonribosomal peptide synthetase module, eight polyketide synthase mod

134 produced by the action of two non-ribosomal peptide synthetase modules (TxtA and TxtB) and a complem

135 pected polyketide synthase and non-ribosomal peptide synthetase modules and tailoring genes.

136 e predicted protein structure consists of 18 peptide synthetase modules with additional modifying dom

137 ructures of two different holo-non-ribosomal peptide synthetase modules, each revealing a distinct st

138 odifies polyketide synthase and nonribosomal peptide synthetase modules.

139 VbsS, which is similar to many non-ribosomal peptide synthetase multienzymes, has a central role.

140 mechanistic studies of the two nonribosomal peptide synthetases NocA and NocB that lie at the heart

141 ied but experimentally elusive non-ribosomal peptide synthetase (NRPS) and NRPS-polyketide synthase (

142 zymatic assembly line with both nonribosomal peptide synthetase (NRPS) and polyketide synthase (PKS)

143 They are synthesized on modular nonribosomal peptide synthetase (NRPS) and polyketide synthase (PKS)

144 ach to clone a thiazole-forming nonribosomal peptide synthetase (NRPS) as a probe, we localized a 172

145 tapeptide on the thio-templated nonribosomal peptide synthetase (NRPS) assembly line protein PacH.

146 e or intermediates bound to the nonribosomal peptide synthetase (NRPS) assembly line.

147 canonical epimerase domains of nonribosomal peptide synthetase (NRPS) assembly lines found in the Yb

148 dimer are made via two distinct nonribosomal peptide synthetase (NRPS) assembly lines, and the respon

149 FUM14 was predicted to encode a nonribosomal peptide synthetase (NRPS) containing two domains, peptid

150 ssociated nature of the encoded nonribosomal peptide synthetase (NRPS) domains and modules.

151 fungal anthranilate-activating nonribosomal peptide synthetase (NRPS) domains through bioinformatics

152 reaction typically catalyzed by nonribosomal peptide synthetase (NRPS) domains.

153 All three are homologous to nonribosomal peptide synthetase (NRPS) domains: VibE is a 2,3-dihydro

154 ed by polyketide synthase (PKS)-nonribosomal peptide synthetase (NRPS) enzymes EpoA-F.

155 The activity of several nonribosomal peptide synthetase (NRPS) enzymes is used to combine the

156 hexapeptides are assembled by non-ribosomal peptide synthetase (NRPS) enzymes remains poorly underst

157 yclic lipopeptides assembled by nonribosomal peptide synthetase (NRPS) enzymes.

158 -L-Trp dipeptide from the MalG non-ribosomal peptide synthetase (NRPS) followed by reverse prenylatio

159 Ebony is a rare example of a nonribosomal peptide synthetase (NRPS) from a higher eukaryote and co

160 rio harveyi BAA-1116 contains a nonribosomal peptide synthetase (NRPS) gene cluster (aebA-F) resembli

161 analyses identified a putative nonribosomal peptide synthetase (NRPS) gene cluster (nan).

162 ajor product of the cryptic has nonribosomal peptide synthetase (NRPS) gene cluster in the human path

163 e applied to the known PKS and non-ribosomal peptide synthetase (NRPS) gene clusters in the Bacillus

164 self-resistance gene (vph) and non-ribosomal peptide synthetase (NRPS) gene probes amplified from S.

165 by a polyketide synthase (PKS)-nonribosomal peptide synthetase (NRPS) hybrid involving proteins EpoA

166 Genetic engineering of the nonribosomal peptide synthetase (NRPS) in the daptomycin biosynthetic

167 main organization of the ncpA-B nonribosomal peptide synthetase (NRPS) is co-linear in arrangement wi

168 tin (Ybt) synthetase, a 230 kDa nonribosomal peptide synthetase (NRPS) making the N-terminus of the Y

169 guillarum, is synthesized via a nonribosomal peptide synthetase (NRPS) mechanism.

170 CrpD-M2 is a unique non-ribosomal peptide synthetase (NRPS) module comprised of condensati

171 acyltransferase, a stand-alone nonribosomal peptide synthetase (NRPS) module, and four flavin-depend

172 ent-state kinetic analysis of a nonribosomal peptide synthetase (NRPS) module.

173 ), including highly dissociated nonribosomal peptide synthetase (NRPS) modules and a variety of tailo

174 cluster encodes a series of six nonribosomal peptide synthetase (NRPS) modules distributed over three

175 ) at the carboxyl terminus of a nonribosomal peptide synthetase (NRPS) or as stand-alone enzymes (Tbe

176 lized metabolites derived from non-ribosomal peptide synthetase (NRPS) or polyketide synthase (PKS).

177 a polyketide synthase (PKS) and nonribosomal peptide synthetase (NRPS) pathways.

178 to require only the two-module non-ribosomal peptide synthetase (NRPS) peramine synthetase (PerA), wh

179 Many bacteria use nonribosomal peptide synthetase (NRPS) proteins to produce peptide an

180 cymA, which encodes a 7-module nonribosomal peptide synthetase (NRPS) responsible for assembly of th

181 rmined the function of a novel non-ribosomal peptide synthetase (NRPS) system carried by a streptococ

182 ybrid polyketide synthase (PKS)/nonribosomal peptide synthetase (NRPS) systems in streptomycetes.

183 The EpoB protein is a non-ribosomal peptide synthetase (NRPS) that catalyzes formation of th

184 PKS is fused to a single module nonribosomal peptide synthetase (NRPS) to synthesize polyketides conj

185 The six-domain, 270 kDa nonribosomal peptide synthetase (NRPS) VibF, a component of vibriobac

186 from the multidomain tyrocidine nonribosomal peptide synthetase (NRPS) was recently shown to catalyze

187 of polyketide synthase (PKS), non-ribosomal peptide synthetase (NRPS), and shikimate pathway compone

188 scent product of the LNM hybrid nonribosomal peptide synthetase (NRPS)-acyltransferase (AT)-less type

189 ecursor of chloramphenicol in a nonribosomal peptide synthetase (NRPS)-based pathway to yield the nit

190 dreds of such thiotemplated yet nonribosomal peptide synthetase (NRPS)-independent biosynthetic gene

191 de synthase (HRPKS, Fub1) and a nonribosomal peptide synthetase (NRPS)-like carboxylic acid reductase

192 inates from a fungal trimodular nonribosomal peptide synthetase (NRPS).

193 protein (EntE, B, F) six-module nonribosomal peptide synthetase (NRPS).

194 of the MBT backbone by a hybrid nonribosomal peptide synthetase (NRPS)/polyketide synthase (PKS) mega

195 Non-ribosomal peptide synthetases (NRPS) and polyketide synthases (PKS

196 Type II nonribosomal peptide synthetases (NRPS) generate exotic amino acid de

197 t for new bioactive substances, nonribosomal peptide synthetases (NRPS) provide biodiversity by synth

198 The initiation module of non-ribosomal peptide synthetases (NRPS) selects and activates the fir

199 ssays reveal two single-module non-ribosomal peptide synthetases (NRPs) that incorporate the beta-ket

200 ing systems can be assembled by nonribosomal peptide synthetases (NRPS) using the conformationally re

201 es, the adenylation domains of non-ribosomal peptide synthetases (NRPS), and firefly luciferase, perf

202 Nonribosomal peptide synthetases (NRPS), fatty acid synthases (FAS),

203 Nonribosomal peptide synthetases (NRPS), fatty acid synthases (FAS),

204 Nonribosomal peptide synthetases (NRPS), polyketide synthases (PKS),

205 five Aspergillus species, the non-ribosomal peptide synthetases (NRPS).

206 domain-domain communication in nonribosomal peptide synthetases (NRPSs) and lay the groundwork for t

207 ackbone of PVD is assembled by non-ribosomal peptide synthetases (NRPSs) and modified by accessory en

208 Single-module nonribosomal peptide synthetases (NRPSs) and NRPS-like enzymes activa

209 Nonribosomal peptide synthetases (NRPSs) and NRPS-like enzymes have d

210 Nonribosomal peptide synthetases (NRPSs) and polyketide synthases (PK

211 l properties are synthesized by nonribosomal peptide synthetases (NRPSs) and polyketide synthases (PK

212 ters encoding the production of nonribosomal peptide synthetases (NRPSs) and polyketide synthases (PK

213 Nonribosomal peptide synthetases (NRPSs) and polyketide synthases are

214 Nonribosomal peptide synthetases (NRPSs) are a family of multidomain,

215 Non-ribosomal peptide synthetases (NRPSs) are megaenzymes responsible

216 Nonribosomal peptide synthetases (NRPSs) are microbial enzymes that p

217 Non-ribosomal peptide synthetases (NRPSs) are modular enzymatic machin

218 The nonribosomal peptide synthetases (NRPSs) are one of the most promisin

219 Polyketide synthases (PKSs) and nonribosomal peptide synthetases (NRPSs) are two related families of

220 Non-Ribosomal Peptide Synthetases (NRPSs) assemble a diverse range of

221 Nonribosomal peptide synthetases (NRPSs) assemble a large group of st

222 Ribosomes and nonribosomal peptide synthetases (NRPSs) carry out instructed peptide

223 Nonribosomal peptide synthetases (NRPSs) catalyze the biosynthesis of

224 thioesterase (TE) domains from nonribosomal peptide synthetases (NRPSs) catalyze the final step in t

225 polyketide synthases (PKSs) and nonribosomal peptide synthetases (NRPSs) comprise giant multidomain e

226 Nonribosomal peptide synthetases (NRPSs) generate the core peptide sc

227 tural products are produced by non-ribosomal peptide synthetases (NRPSs) in an assembly-line fashion.

228 eptidyl precursors derived from nonribosomal peptide synthetases (NRPSs) into 2,5-diketopiperazines (

229 Nonribosomal peptide synthetases (NRPSs) make many natural products o

230 s on the carrier domains of the nonribosomal peptide synthetases (NRPSs) or polyketide synthases (PKS

231 Nonribosomal peptide synthetases (NRPSs) produce a wide variety of pe

232 teria, polyketide synthases and nonribosomal peptide synthetases (NRPSs) produce complex lipidic meta

233 cidic lipopeptides assembled by nonribosomal peptide synthetases (NRPSs) that are known to display va

234 olyketide synthases (PKSs) and non-ribosomal peptide synthetases (NRPSs) that contain repeated, coord

235 arison with the large number of nonribosomal peptide synthetases (NRPSs) that release their peptide p

236 Nonribosomal peptide synthetases (NRPSs) underlie the biosynthesis of

237 Nonribosomal peptide synthetases (NRPSs) use phosphopantetheine (pPan

238 ng polyketide synthases (PKSs), nonribosomal peptide synthetases (NRPSs), and mixed PKS/NRPS systems,

239 cluster predicted that the two nonribosomal peptide synthetases (NRPSs), BlmIV and BlmIII, are respo

240 f enzyme-bound intermediates in nonribosomal peptide synthetases (NRPSs), mass spectrometry is used t

241 cin A gene cluster encodes two non-ribosomal peptide synthetases (NRPSs), NocA and NocB, predicted to

242 nes encoding fatty acid ligase, nonribosomal peptide synthetases (NRPSs), regulators, transporters, a

243 d from amino acid precursors by nonribosomal peptide synthetases (NRPSs), which are organized into mo

244 ti-enzyme assembly lines called nonribosomal peptide synthetases (NRPSs).

245 rge, multidomain enzymes called nonribosomal peptide synthetases (NRPSs).

246 nthesis of natural products by non-ribosomal peptide synthetases (NRPSs).

247 ts are produced by multidomain non-ribosomal peptide synthetases (NRPSs).

248 e also shown to originate from non-ribosomal peptide synthetases (NRPSs).

249 we report the structure of the nonribosomal peptide synthetase ObiF1, highlighting the structure of

250 creted proteins, a multisubunit nonribosomal peptide synthetase operon, and genes encoding two member

251 nd has no sequence homology to non-ribosomal peptide synthetase or bacterial cyclodipeptide synthase.

252 irst direct characterization of nonribosomal peptide synthetase oxidase domain activity and will lead

253 bacterin is biosynthesized by a nonribosomal peptide synthetase pathway.

254 ty of future engineering within nonribosomal peptide synthetase pathways using oxidase domains.

255 two module polyketide synthase-nonribosomal peptide synthetase (PKS-NRPS) that generates cyclo-aceto

256 two module polyketide synthase-nonribosomal peptide synthetase (PKS-NRPS) that makes and releases cy

257 ngle-module polyketide synthase-nonribosomal peptide synthetase (PKS-NRPS), although two separate hex

258 es a hybrid polyketide synthase nonribosomal peptide synthetase (PKS-NRPS), which resembles iterative

259 lyketide siderophores involves non-ribosomal peptide synthetase, polyketide synthase and non-ribosoma

260 tors biosynthesized by a hybrid nonribosomal peptide synthetase-polyketide synthase (NRPS-PKS) system

261 of the nos synthetase, a mixed non-ribosomal peptide synthetase-polyketide synthase, is co-linear in

262 nthetic gene cluster encoding a nonribosomal peptide synthetase/polyketide synthase accompanied by a

263 sized by the action of a hybrid nonribosomal peptide synthetase/polyketide synthase in the myxobacter

264 y backbone assembly by a hybrid nonribosomal peptide synthetase/polyketide synthase.

265 osynthetic loci encoding hybrid nonribosomal peptide synthetase/polyketide synthases consistent with

266 II thioesterase from the hybrid nonribosomal peptide synthetases/polyketide synthase rifamycin biosyn

267 uced genes showed homology with nonribosomal peptide synthetases/polyketide synthases.

268 Peptide synthetases produce a wide variety of peptide se

269 Nonribosomal peptide synthetases produce diverse natural products usi

270 inal thioesterase domain of the nonribosomal peptide synthetase producing the lipopetide surfactin (S

271 500 microM sample of the 33 kDa nonribosomal peptide synthetase protein EntB.

272 le motifs characteristic of the nonribosomal peptide synthetase protein family were identified in eac

273 end of the sequence reported here encodes a peptide synthetase required for the activation and incor

274 The excised TE domain from the nonribosomal peptide synthetase responsible for the production of the

275 n domains of PchE and PchF, the nonribosomal peptide synthetases responsible for the biosynthesis of

276 Nonribosomal peptide synthetases responsible for the production of ma

277 nd the following spacer is typical of fungal peptide synthetases, showing good conservation of the si

278 evealed the central role of the nonribosomal peptide synthetase Sln9 in constructing and installing t

279 covalently modified serines in nonribosomal peptide synthetases, streamlined methodologies described

280 All six domains of this nonribosomal peptide synthetase subunit, three phosphopantetheinylata

281 that communication between two non-ribosomal peptide synthetase subunits responsible for chain releas

282 d by a four-subunit, ten-domain nonribosomal peptide synthetase system, VibE, VibB, VibH, and VibF, u

283 nstalled into the scaffold by a nonribosomal peptide synthetase that also performs the subsequent mac

284 ) domain of the Yersinia pestis nonribosomal peptide synthetase that biosynthesizes the siderophore y

285 Here, we uncover a nonribosomal peptide synthetase that is induced in male worms upon pa

286 The non-ribosomal peptide synthetase that synthesizes HC-toxin has only on

287 mbling bacterial polyketide and nonribosomal peptide synthetases that produce antibiotics.

288 ins of polyketide synthases and nonribosomal peptide synthetases to macrocycles via covalent enzyme b

289 one hybrid polyketide synthase-nonribosomal peptide synthetase together with cytochrome P450s and fl

290 zed from a classically derived non-ribosomal peptide synthetase tripeptide (from delta-(L-alpha-amino

291 The most common BGCs are non-ribosomal peptide synthetases, type 1 polyketide synthases, terpen

292 ssion of nrps1 which encodes a non-ribosomal peptide synthetase was elevated in the ompR and envZ str

293 ogous to adenylation domains of nonribosomal peptide synthetases, was identified as specific for the

294 mately 450 residue E domains of nonribosomal peptide synthetases were constructed, and the PheATE der

295 ynthesis gene clusters encoding nonribosomal peptide synthetases were identified, emphasizing the pos

296 syringomycin are synthesized by nonribosomal peptide synthetases which are encoded by the syringomyci

297 sual hybrid polyketide synthase-nonribosomal peptide synthetase, which resembles iterative polyketide

298 tural basis for catalysis with non-ribosomal peptide synthetases will facilitate bioengineering to cr

299 We identify a nonribosomal peptide synthetase with an unusual domain architecture a

300 on of polyketide synthases and non-ribosomal peptide synthetases with unusual domain structures, incl