ライフサイエンスコーパス: peptide transporter

1 thers empty MHC class I molecules to the TAP peptide transporter.

2 induced by carbon starvation and to encode a peptide transporter.

3 lex between the class I molecule and the TAP peptide transporter.

4 r of PTR2, a gene encoding the transmembrane peptide transporter.

5 ytes, confirming the function of HvPTR1 as a peptide transporter.

6 ate studies on the regulatory aspects of the peptide transporters.

7 ly elucidated primary structure of mammalian peptide transporters.

8 ss of secondary transporters named SbmA-like peptide transporters.

9 eported guanidinium-rich oligocarbonates and peptide transporters.

10 y, the peptides nevertheless are absorbed by peptide transporters.

11 ow TAP1 expression and a reduced function of peptide transporters.

12 ession of genes for aquaporin (AQP) 3, AQP4, peptide transporter 1 (PepT1), sodium/glucose co-transpo

13 In Antarctic icefish (Chionodraco hamatus) peptide transporter 1 (PEPT1), the first transporter clo

14 AAs, respectively) and induced expression of peptide transporter 1 (PEPT1).

15 interferon-induced genes, and the ER antigen peptide transporter 1 (TAP1).

16 ndent glutamate/aspartate transporter 3, and peptide transporter (1), lipid transport and metabolism-

17 The human peptide transporter 2 (PEPT2) expressed by proximal tubu

18 Here we demonstrated that Slc15a1, a peptide transporter also known as Pept1, was predominant

19 lize the structural segments stabilizing the peptide transporter and investigated which of these stru

20 indicated that DtpD functions as a canonical peptide transporter and is, therefore, a valid model for

21 ion of a subset of genes, including the TAP1 peptide transporter and proteasome subunit beta type 9 (

22 ate genes encode an extensin-like protein, a peptide transporter and two unknown proteins, which may

23 ession of TAP, the MHC-encoded cytosol to ER peptide transporter, and (iii) was blocked by pinocytosi

24 oteins expressed in the ovary: opt1, a novel peptide transporter, and nod, a member of the kinesin fa

25 lts show that tapasin links Qa-1b to the TAP peptide transporter, and that tapasin facilitates the de

26 e CUP9-TUP1-SSN6 repressor complex, the PTR2 peptide transporter, and the UBR1-dependent N-end rule p

27 a member of the oligopeptide (OPT) family of peptide transporters, and a recessive mutant allele, opt

28 tation in the gene encoding subunit 1 of the peptide transporter associated with antigen processing (

29 In human B lymphoblasts, inhibition of the peptide transporter associated with antigen processing (

30 that tethers empty class I molecules to the peptide transporter associated with antigen processing (

31 yed 58% identity to the Arabidopsis thaliana peptide transporter AtPTR2-B.

32 APPROACH: A peptide transporter comprising sixteen lysine residues a

33 The heterodimeric peptide transporter consists of two homologous subunits,

34 pneumoniae Sap (sensitivity to antimicrobial peptides) transporter contributes to bacterial-host cell

35 rast, several citric-acid cycle enzymes, the peptide transporter CstA, PEB1 aspartate/glutamate trans

36 wo approaches were taken to characterize the peptide transporter defect in this mutant strain.

37 "Empty" HLA-Cw7 expressed in peptide transporter-deficient cells and HLA-Cw7 loaded w

38 Lack of amino acid transporters and peptide transporter delays the absorption of amino acids

39 t presented to CD8+ T cells via a proteasome/peptide transporter-dependent pathway.

40 Peptide transporters display a remarkable capacity to re

41 One laboratory has reported that the peptide transporter encoded by the Tap1 gene within H2g7

42 r the catalytic function of the H(+)-coupled peptide transporters expressed in the intestine and the

43 Arabidopsis thaliana nitrate transporter 1/peptide transporter family (NPF) 6.3 is a dual-affinity

44 -ATAF-CUC (NAC), and nitrate transporter 1 / peptide transporter family (NPF), exhibited duplications

45 xylem loading from the Nitrate transporter 1/Peptide Transporter family (NPF2.4).

46 nes of evidence that a member of the nitrate/peptide transporter family is required for the accumulat

47 is study, PEPT2 is the primary member of the peptide transporter family responsible for dipeptide upt

48 of the Lotus japonicus nitrate transporter1/peptide transporter family, LjNPF8.6 The phenotypic char

49 scherichia coli, a prokaryotic member of the peptide transporter family.

50 the first structural view of a member of the peptide transporter family.

51 (Arabidopsis thaliana) NITRATE TRANSPORTER1 PEPTIDE TRANSPORTER FAMILY6.3.

52 for Medicago truncatula NITRATE TRANSPORTER1/PEPTIDE TRANSPORTER Family6.8) in the inhibition of prim

53 diated intestinal absorption, via the hPEPT1 peptide transporter, followed by the rapid and complete

54 rly characterized family of peptide/modified peptide transporters found in archebacteria, bacteria, f

55 milar prokaryotic homologue of the mammalian peptide transporters from Shewanella oneidensis.

56 Comparison with peptide transporters further reveals how the NRT1/PTR fa

57 mino acids or short peptides up-regulate the peptide transporter gene PTR2, thereby increasing the ca

58 ave shown increased frequency of alleles for peptide transporter genes TAP1 (0101) and TAP2 (0101) ge

59 ein, a plant peptide hormone, and many OLIGO PEPTIDE TRANSPORTER genes, all of which may lead to indu

60 In addition, the peptide transporters have immediate pharmacologic releva

61 -L-glutamine (Gly-Gln) of the proton-coupled peptide transporter, hPepT1, in the Caco-2 human intesti

62 with antigen processing (TAP), which is the peptide transporter in the endoplasmic reticulum (ER) me

63 o understand further the purpose of specific peptide transporters in brain, we have generated PEPT2-d

64 iously reveal, as illustrated by examples of peptide transporters in Escherichia coli and nitrogenase

65 structures provide a unique insight into how peptide transporters interact with xenobiotic molecules

66 Expression of the PTR2 peptide transporter is induced not only by amino acids b

67 One candidate for an alternative peptide transporter is P-glycoprotein, which transports

68 In contrast, structural information on peptide transporters is very sparse.

69 tein Mdl1 was identified as an intracellular peptide transporter localized in the inner membrane of y

70 Proton-coupled peptide transporters mediate the absorption of a large v

71 multiple proteases and toxins, and iron- and peptide-transporter molecules, which are upregulated in

72 omimetics that might specifically target two peptide transporters (namely, PEPT1 and PEPT2) upregulat

73 ed protein response, and inhibition of a gut peptide transporter partially suppressed C. elegans resp

74 was found to be negatively regulated by the peptide transporter PEPT-1, as well as the target of rap

75 ed exopher elevation requires the intestinal peptide transporter PEPT-1, lipid synthesis transcriptio

76 Two peptide transporters, PEPT 1 and PEPT 2, have been clone

77 colonic mucosal growth and expression of the peptide transporter PepT1 in adults with or without SBS.

78 e step: 4-aminophenylacetic acid (epithelial peptide transporter PepT1 inhibitor), 3,4-dihydroxypheny

79 sh border enzyme dipeptidyl peptidase IV and peptide transporter PepT1 messenger RNA levels were dete

80 tide derivatives by the mammalian intestinal peptide transporter PepT1 were investigated, using the X

81 The intestinal H(+)-coupled peptide transporter PepT1, displays a broad substrate sp

82 n body are facilitated by the proton-coupled peptide transporters PepT1 (SLC15A1) and PepT2 (SLC15A2)

83 N2 were good substrates for the H(+)-coupled peptide transporters PEPT1 and PEPT2.

84 are conserved among the intestinal and renal peptide transporters (PEPT1 and PEPT2, respectively) fro

85 tic analysis of the rat kidney high-affinity peptide transporter PepT2 expressed in Xenopus oocytes.

86 of the outward open conformation of the rat peptide transporter PepT2 in complex with an inhibitory

87 ent cryo-EM structures of the proton-coupled peptide transporter, PepT2 from Rattus norvegicus, in co

88 ic G protein-coupled receptor (beta2AR), the peptide transporter (PepTSt), diacylglycerol kinase (Dgk

89 solution structural studies of the bacterial peptide transporter PeptTSo2 by single-particle cryo-ele

90 epT1 and PepT2, the mammalian proton coupled peptide transporters (POTs), function to assimilate and

91 mpaired in macrophages deficient in PepT1, a peptide transporter previously implicated in MDP interna

92 pecific homolog of protein phosphatase 2C, a peptide transporter protein, and a nodule-specific form

93 antigen loss, and (b) downregulation of the peptide-transporter protein TAP-1 expression by this pat

94 al, low-affinity Nitrate Transporter1 (NRT1)/Peptide Transporter (PTR) family member NPF7.3/NRT1.5 is

95 unbiased visual screen, which identified the peptide transporter Ptr2 and the ammonium permease Mep3

96 ets CUP9, a transcriptional repressor of the peptide transporter PTR2, through an internal (non-N-ter

97 of Cup9, a transcriptional repressor of the peptide transporter Ptr2.

98 Peptide transporters (PTRs) of the large PTR family faci

99 urease, iron uptake systems, amino acid and peptide transporters, pyruvate metabolism enzymes, and a

100 Here we show that two endo-lysosomal peptide transporters, SLC15A3 and SLC15A4, are preferent

101 (SGK) and the proteasome-associated antigen peptide transporter subunit 1 (Tap1), was confirmed afte

102 EBV miRNAs directly target the peptide transporter subunit TAP2 and reduce levels of th

103 his study provides new evidence for multiple peptide transporter systems in Arabidopsis, suggesting a

104 lbumin secreted by the parasite requires the peptide transporter TAP (transporter associated with ant

105 epsin-positive amphisomal vacuoles, to which peptide transporter TAP and upregulated MHC class I (MHC

106 al processing components like proteasome and peptide transporter TAP.

107 lass I chains from the ER, inhibition of the peptide transporter (TAP) involved in antigen presentati

108 bility Complexes (MHCs) and to Transmembrane Peptide Transporter (TAP), as well as an annotated list

109 res formation of a complex between the 'ABC' peptide transporter, TAP, and newly synthesized class I

110 s is because p53 regulates expression of the peptide transporter Tap1 and the aminopeptidase Erap1, w

111 c loop 1 of the human homodimeric, lysosomal peptide transporter TAPL (transporter associated with an

112 nce-associated macrophage protein, and oligo-peptide transporters, were differentially regulated betw

113 , fungi, and bacteria they are predominantly peptide transporters, whereas in plants the family has d

114 Here, we report creation of a 36-amino acid peptide transporter, which can transport a protein to th