ライフサイエンスコーパス: peptides

1 was performed to identify motifs of binding peptides.

2 fication/quantification of partially labeled peptides.

3 ions (PTMs) affecting single amino acids and peptides.

4 gnition of the autoreactive TCR with foreign peptides.

5 ernal standards to quantify chosen surrogate peptides.

6 insights from the "ocean" of known bioactive peptides.

7 ividual capacity to present pathogen-derived peptides.

8 rated the extent of Cu(2+) binding among the peptides.

9 and sequencing of MHC class I- and II-bound peptides.

10 e provided for gas-phase research on neutral peptides.

11 aligning the sequences of the most enriched peptides.

12 ategy for comprehensive analysis of modified peptides.

13 olayers (SAMs) of helical lanthanide-binding peptides.

14 ssion to quantify the modification extent of peptides.

15 ng the same Ag recognize the same off-target peptides.

16 otential for investigating other therapeutic peptides.

17 rons and transport of APP-derived neurotoxic peptides.

18 and T-cell reactivity against citrullinated peptides.

19 ond the metabolic stabilization of bioactive peptides.

20 rferon gamma-secreting T-cell response to M1 peptides.

21 ishes cross-reactive from non-cross-reactive peptides.

22 duction, upon re-stimulation with SARS-CoV-2 peptides.

23 ited electronic states of model amyloid-like peptides.

24 of longer amyloidogenic amyloid-beta (Abeta) peptides.

25 mination is likely achieved using just a few peptides.

26 es, with no cross-recognition of YFV-derived peptides.

27 ostasis by degrading circulating angiotensin peptides.

28 erent classes of conformationally stabilized peptides.

29 t to HLA-A2 or to HLA-A2 loaded with control peptides.

30 cross-reacted with 10 of the 15 nonvaccine M peptides.

31 ation through cooperation between individual peptides.

32 n, processing, and toxicity of Abeta (Abeta) peptides.

33 he advantages and benefits of various native peptides.

34 of ultra-low concentrations of the Abeta-40 peptides.

35 try for strong binders than for low-affinity peptides.

36 A-A, -B, and -C genotypes for all SARS-CoV-2 peptides.

37 rease the prediction accuracy of immunogenic peptides.

38 occur, releasing large numbers of endogenous peptides.

39 is the delineation of the role of individual peptides.

40 omplex class I (MHC I) molecules loaded with peptides.

41 dentification of the first endogenous opioid peptides.

42 o see no increase in GSIS in response to CCK peptides.

43 A large number of Cys peptides (412) were redox switched, representing central

44 R, LKGYGGVSLPEW, and LKALPMH), antimicrobial peptides (AASDISLLDAQSAPLR, IIAEKTKIPAVF, IDALNENK, and

45 Proteins and peptides account for 20-75% of marine biota biomass, of

46 heptad sites between vaccine and nonvaccine peptides accurately distinguishes cross-reactive from no

47 ions following HCD fragmentation of labeled peptides acquired on Orbitrap platforms at a minimum of

48 diction of endogenous HLA class I-associated peptides across a large fraction of the human population

49 The SPACE analysis shows that, whereas both peptides act locally, the inhibitor EPF1 exerts longer r

50 elineation of interfaces and the modeling of peptides acting as inhibitors of protein-protein interac

51 ragments of bacterial peptidoglycan (muramyl peptides) activate innate immune cells through nucleotid

52 Exon 17b peptides also promote fodrin-actin complex formation.

53 right properties, for example Antimicrobial peptides (AMPs), can disrupt this protective barrier by

54 d stimulated to release stored antimicrobial peptides (AMPs).

55 -presenting cells, which function to present peptides and activate CD4 T cells.

56 ers resistance to host-derived antimicrobial peptides and bile, respectively.

57 , which enhanced production of antimicrobial peptides and caused microbiome changes.

58 Peptides and free amino acids are naturally generated in

59 These peptides and macrocycles, along with the dimeric model o

60 binding was retained against both rearranged peptides and no peptide (r = 0.85 and r = 0.79, respecti

61 t that the self-replicator consisted of both peptides and nucleic acid strands.

62 ts often study how modern biopolymers, e.g., peptides and nucleic acids, could have originated in the

63 stems to prepare natural biopolymers such as peptides and oligonucleotides.

64 pacts the efficacy and safety of therapeutic peptides and proteins (TPPs), understanding of the metab

65 Amyloidogenic peptides and proteins aggregate into fibrillary structur

66 red through the labeling of 6-Trp-containing peptides and proteins ranging from 1 to 14 kDa.

67 satile and selective method to functionalize peptides and proteins through free-radical-mediated dech

68 ter has been the main application of VCD for peptides and proteins, although this is now reinforced b

69 s been used in mass spectrometry to fragment peptides and proteins, providing fragments mostly simila

70 IRMPD exploited in dissociation protocols of peptides and proteins.

71 of conformational isomers of disulfide-rich peptides and proteins.

72 ind amyloid fibrils formed from many natural peptides and proteins.

73 sing label-free quantification of unmodified peptides and robust linear regression to quantify the mo

74 (4) information about a library of synthetic peptides and root and nodule phenotyping data from synth

75 Furthermore, host defense antimicrobial peptides and small-molecule peptide mimetics also activa

76 The ability to generate large panels of peptides and subsequently large bodies of peptide-MHC-II

77 oid plaques composed of amyloid beta (Abeta) peptides and the cerebrospinal fluid concentrations of t

78 the potential interactions between different peptides and the main anthocyanins from eggplant peels.

79 e method utilizing the anchor antibodies and peptides and the traditional capture antibody printing a

80 on by enzymatic cleavage of immunoregulatory peptides and through its soluble form (sDPP4) that direc

81 sport substrate proteins implies that signal peptides and transmembrane domains pass through the site

82 identify 21 cytokines by two or more unique peptides and two cytokines by a single unique peptide.

83 localized and delocalized motions present in peptides and where they can be found in the electromagne

84 activated receptor 2 agonist and antagonist peptides, and a tryptase-neutralizing mAb on human umbil

85 nd their interactions on the profiles of pH, peptides, and flavanols in the bean during the incubatio

86 This is demonstrated for small molecules, peptides, and proteins up to 66 kDa on three commerciall

87 source is demonstrated using beta-blockers, peptides, and proteins.

88 ies into both rigid and flexible macrocyclic peptides, and that scaffold rigidity can be used to tune

89 analysis workflows, targeted different PTEN peptides, and were performed in different laboratories,

90 the balanced synthesis of its main effector peptides Ang (angiotensin) II and Ang (1-7).

91 techniques used in the purification of such peptides are discussed.

92 The isobarically labeled peptides are fragmented into sets of b- and y-ion cluste

93 Cyclic peptides are reported to have antibacterial, antifungal,

94 cerebrospinal fluid concentrations of those peptides are used as a biomarker for AD.

95 NPs (natriuretic peptides) are cardiac-derived hormones that promote natr

96 way for future development of this class of peptides as a spray-on fungistat/fungicide.

97 ion of the NTE from MOB1A or addition of NTE peptides as binding competitors attenuated YAP1 recruitm

98 of metal-organic coordination networks using peptides as building blocks.

99 aightforward approach to design new targeted peptides as HIV-1 fusion inhibitors and lead us to defin

100 n composed of several concatenated signature peptides as internal standard.

101 ely demonstrate the nature and extent of EPF peptides as non-cell autonomous local signals and provid

102 VZV glycoprotein B (gB) peptides assembled into fibrils and catalyzed amylin and

103 binding and beta-arrestin recruitment) of 22 peptides at each of the three opioid receptors.

104 thymidine kinase, antibiotics, antimicrobial peptides, bacterial antibodies, bacteriophages, and bact

105 in maintaining effective cyclization of such peptides bearing 3,5-dihydroxyphenylglycine residues at

106 e design and engineering of novel functional peptides because hybrid peptides combine the advantages

107 charge-states of the same peptide, different peptides belonging to the same proteins, and individual

108 Peptides below 1400 Dalton had the highest activity, and

109 heat-damage and occurrence of the bioactive peptides beta-casomorphins (BCMs).

110 n elicited antibodies against AipA and Asp14 peptides but not OmpA peptide.

111 ulation of amyloidogenic mutant BRI2-derived peptides, but the mechanistic details remain unclear.

112 s fractionated into <1, 1-3, 3-5, and >5 kDa peptides by membrane ultrafiltration.

113 rometry responses (signal-to-noise ratio) of peptides by more than 1 order of magnitude on average af

114 that are cross-linked between adjacent wall peptides by penicillin-binding proteins to confer robust

115 thus enabling extraction of high amounts of peptides by the new C18/PAN coating.

116 lecules, including the complement activation peptides, C3a and C5a.

117 nvolved in the biosynthesis of antimicrobial peptides, camalexin, and 4-OH-ICN, as well as pathogenes

118 is technology to evaluate if M. tuberculosis peptides can also be detected in individuals with latent

119 Functional analysis demonstrated that EBV peptides can bind to HLA-E and block inhibition of NK ce

120 and may influence the availability of mutant peptides capable of driving effective response to immune

121 Cystine-dense peptides (CDPs) have drawn recent interest as drugs or d

122 ity to selectively quantify other endogenous peptides cleaved by peptidases whose concentrations are

123 of novel functional peptides because hybrid peptides combine the advantages and benefits of various

124 Szeto-Schiller (SS) peptides comprise a class of amphipathic tetrapeptides t

125 is we uncover previously uncharacterized CIF peptides conserved among higher plants.

126 tail of keyhole limpet hemocyanin-conjugated peptides corresponding to the AipA, Asp14, and OmpA bind

127 tibodies directed at 58 (15-mer) overlapping peptides, covering the entire sequence of ovomucoid, in

128 Cell penetrating peptides (CPP) have the ability to rapidly internalize a

129 onolayers is conjugation to cell-penetrating peptides (CPPs); however, very little is known about the

130 Here we show that cationic proto-peptides (depsipeptides and polyesters), either produced

131 in our laboratory, macrocyclic beta-hairpin peptides derived from Abeta(16-22) and Abeta(30-36), cap

132 viously designed and synthesized macrocyclic peptides derived from Abeta(17-23) and Abeta(30-36) that

133 olute values were observed for the P2 and P3 peptides derived from alpha- and gamma-gliadins.

134 uggest that non-canonical tumor-specific HLA peptides derived from annotated non-coding regions could

135 In this study, we designed synthetic peptides derived from indolicidin, a naturally occurring

136 hexamers formed by macrocyclic beta-hairpin peptides derived from the central and C-terminal regions

137 Peptides designed to include a glycine-proline-hydroxypr

138 Of the 49 heat-stable peptides detected in pure cooked rabbit meat, three were

139 Halotryptophan-containing RGD peptides display increased affinity toward integrin alph

140 nteractions with a wide variety of antigenic peptides displayed in a given major histocompatibility c

141 ion, our findings suggest that cysteine-rich peptides diversified for a variety of specialized functi

142 crin, SERPINB7 and SERPINB13), antimicrobial peptides (e.g. B-defensins like DEFB4A, DEFB4B, DEFB103A

143 e used mass spectrometry to profile >185,000 peptides eluted from 95 HLA-A, -B, -C and -G mono-alleli

144 w cytometry of the five most highly abundant peptides (EP1, -2, -3, -7 or EP9) showed strong binding

145 lico techniques, we demonstrate that the two peptides, even if applied individually, transform origin

146 e methods include directly administering the peptides ex vivo (i.e., to excised tissue) or in vivo (i

147 ivo and an enhanced response to weak agonist peptides ex vivo.

148 We find that the most potent pore-forming peptides exhibit strong interpeptide interactions, inclu

149 e generation of single, terminal proteotypic peptides followed by chemical enrichment or depletion st

150 II (MHCII) bind and present pathogen-derived peptides for CD4 T cell activation.

151 l interest, e.g. for the synthesis of cyclic peptides for drug design or for protein engineering.

152 HLA-B*46:01 had the fewest predicted binding peptides for SARS-CoV-2, suggesting that individuals wit

153 potency compared to those of the monovalent peptides for the human Na(V)1.4 channel.

154 s spectrometry analysis of HLA class I-bound peptides from 35 PDAC patient tumors.

155 This study was aimed to produce bioactive peptides from optimally fermented tempe, and map their o

156 bit the release of puromycin-labeled nascent peptides from ribosomes.

157 rst study to focus on the screening of umami peptides from tempeh.

158 solvents improves digestion, generating more peptides from the rigid beta-barrel regions, without com

159 lti-step peptide search strategy to identify peptides generated by various types of proteolysis.

160 nical usefulness of urine gluten immunogenic peptides (GIP) as a biomarker monitoring GFD adherence i

161 The cyclic peptides have a combination of piperazine or hydrazine l

162 CANCE STATEMENT The neuropeptide VGF and its peptides have been associated with many metabolic and ne

163 Oxytocin-like peptides have been implicated in the regulation of a wid

164 om acylation to C-C bond formation, in which peptides have been successfully employed.

165 Bicyclic peptides have great therapeutic potential since they can

166 Natriuretic peptides have many physiological actions and participate

167 The evolved peptides have these activities in vitro even in the pres

168 peutic interventions such as heparin-binding peptides (HBPs), which are used for other cases, can be

169 ed in complex with their orthosteric agonist peptides, however, little is known about their extracell

170 nicity of HAdVs, the structures of synthetic peptides identical or very similar to the adenovirus 12

171 entify both nonbiotinylated and biotinylated peptides in a single experimental setup.

172 ancreatic, gastrointestinal and hypothalamic peptides in addition to exosomes.

173 pling is useful for multiple conjugations of peptides in conjunction with conventional conjugation re

174 elenization to give several different cyclic peptides in good yields.

175 l improved modestly after adding natriuretic peptides in men (DeltaC-statistic = 0.006; likelihood ra

176 Our findings reveal distinct effects of IAPP peptides in modulating Abeta aggregation and toxicity an

177 esin to facilitate the chemical synthesis of peptides in organic solvent as well as the enzymatic syn

178 MRM-MS) assays that detected M. tuberculosis peptides in serum extracellular vesicles from TB patient

179 y obtaining a complete data set of PSMalpha3 peptides in solution and with n-dodecyl-beta-d-maltoside

180 lphabeta T cells that express upstream Vbeta peptides in surface TCRs and carry Trbv31-DJbeta2 rearra

181 Endogenous opioid peptides in the amygdala regulate many of our behaviors

182 re of acetylated/nonacetylated alpha-tubulin peptides in the background of human olfactory neurospher

183 results support the use of amaranth protein/peptides in the elaboration of functional foods for hype

184 ortin (POMC) neuron-producing beta-endorphin peptides in the hypothalamus in a postnatal rat model of

185 ide arrays, in casu containing 70,000 random peptides in triplicates.

186 e of catabolism of host-derived proteins and peptides in vivo is less well understood.

187 shared and tumor-specific non-canonical HLA peptides, including an immunogenic peptide derived from

188 is and across the cell layers in which these peptides influence patterns.

189 nto the primary sequences of self-assembling peptides influences molecular-level packing and supramol

190 of chemokines, cytokines, and antimicrobial peptides involved in pathogen clearance.

191 eventing aggregation of amyloid beta (Abeta) peptides is a promising strategy for the treatment of Al

192 concentrate (WPC 35) to produce antioxidant peptides is an innovative approach which can provide add

193 eciphering interactions between bacteria and peptides is important in understanding marine carbon and

194 ginating from self-assembly of alpha-helical peptides is incomplete.

195 The selection of good biomarker peptides is of high importance to develop a specific, un

196 Capture and release of peptides is often a critical operation in the pathway to

197 cases, the binding between MHC and antigenic peptides is the most selective step in the antigen prese

198 the identified peptides were ACE-inhibitory peptides (LDAQSAPLR, LKGYGGVSLPEW, and LKALPMH), antimic

199 chanisms by which chemical species (cations, peptides, lipids, lignin, carbohydrates, and some low-mo

200 The first syntheses of the cytotoxic peptides lipovelutibols B and D are described.

201 IDALNENK, and VLVLDTDYK), DPP-IV-inhibitory peptides (LKALPMH, LKPTPEGDLEIL, LKGYGGVSLPE, LKPTPEGDLE

202 h have similar folding conformation to alpha-peptides, making them an ideal molecular scaffold to des

203 and membrane-bound and secreted proteins and peptides mediate many important physiological and pathop

204 Here, we show that constrained 31-residue-peptides ('msR4Ms') designed to mimic the CXCR4-binding

205 The N-terminally extended peptides N+1, N+2, N+4, N+6, N+8, N+10, N+12, and N+14 a

206 interactions of representative amyloidogenic peptides, namely, the 106-126 fragment of prion protein

207 Pore formation by membrane-active peptides, naturally encountered in innate immunity and i

208 Since HIV-1 fusion inhibitor peptides need to be embedded in the membrane to properly

209 Nonribosomal peptides (NRPs) are natural products that are biosynthes

210 We identify host-derived peptides of 4-11 residues, varying in both charge and co

211 The binding of amyloid-beta peptides of different concentrations to the surface of t

212 Synthetic overlapping 15-mer peptides of peanut allergens (Ara h 1-11) were spotted o

213 es solid-phase immobilization of proteolytic peptides of proteins, which modifies Tn by glycosyltrans

214 the form of a collection of conserved short peptides) of each subfamily, and thus were further used

215 Seven peptides on Ara h 1, Ara h 2, and Ara h 3 were bound mor

216 We characterized the effects of these two peptides on K. pneumoniae, along with their physical int

217 akes use of a reactive linker to form cyclic peptides on the phage surface while simultaneously intro

218 ed the presence of only two short allergenic peptides on the surface of CpCP3, which was highly susce

219 e selective recognition of lysine-containing peptides, opening new perspectives in the field of pepti

220 of methods now exist for the modification of peptides or proteins, many of these target a handful of

221 ry input for the server consists of a set of peptides or proteins, optionally with PTM sites, and the

222 Application of this method to tryptic peptides originating from O-GlcNAcylated proteins TAB1 a

223 released a higher concentration of specific peptides, particularly anti-hypertensives, from yogurt c

224 e observations demonstrate that our designed peptides perturb TJs in human lung as well as human and

225 Instead, the opioid peptides play complex and overlapping roles in a variety

226 Fifty T. cruzi peptides predicted to bind a broad range of class I and

227 ed cells expressing the target virus-derived peptides presented by human leukocyte antigen (HLA).

228 T cell blasts are stimulated by recombinant peptides presented on MHC Ag alone, we show that differe

229 aturally presented influenza A virus-derived peptides previously identified from virally infected cel

230 Both peptides protected greater than 80% mice from infection-

231 or various kinds of molecules including DNA, peptides, proteins, and oligosaccharides.

232 Importantly, the nitro-alkylated peptides provide a new handle for site-selective fluorin

233 Isolated aromatic amino acids and short peptides provide benchmark cases to study, at the molecu

234 y mass spectrometry in order to identify the peptides responsible for that activity.

235 The (glyco)peptides resulting from a subsequent digestion using try

236 n complex with conventional and Phospho-FFAT peptides revealed new mechanisms of interaction.

237 ydrides, for the synthesis of peptidyl-RNAs, peptides, RNA oligomers and primordial phospholipids.

238 In this study, several families of peptides, selected for the ability to partition into and

239 A total of 11 peptides sequences were identified in the fractions eval

240 on, leading to the recognition of off-target peptides sharing little similarity with the cognate pept

241 Only peptides showing processing robustness were retained.

242 Cationic proto-peptides significantly increase the thermal stability of

243 rs, using interferon-gamma-based assays with peptides spanning SARS-CoV-2 except ORF1.

244 Peptides such as gastrin-releasing peptide receptors tar

245 and also requires the presence of activator peptides, such as benzoyl-leucyl-leucine (Bz-LL), for fu

246 eta-cells, we analyzed the HLA-A3-restricted peptides targeted by circulating CD8(+) T cells.

247 Thrombin-derived C-terminal peptides (TCPs), including a major 11-kDa fragment (TCP9

248 ing synthetic nanogels with a combination of peptides that address barriers to cytosolic delivery ind

249 Orbitides are a class of cyclic peptides that are small, head-to-tail cyclized, composed

250 function characterization, we present simple peptides that bind alpha-cobratoxin (alpha-Cbtx) and pre

251 Here we report the modification of two peptides that comprise a coiled-coil heterodimer pair wi

252 further stabilize oligomers of Abeta-derived peptides that contain more of the native sequence and th

253 This PCSK9 inhibitor is one of many peptides that could benefit from bioactive cyclization,

254 ationally designed a series of seven-residue peptides that form hemin-binding catalytic amyloids to f

255 on resonance, we identified parasite-derived peptides that have the sequence-specific ability to incr

256 The relevant peptides that induced pathogenic CD4(+) T cells at the i

257 Bicycles are constrained bicyclic peptides that represent a promising binding modality for

258 e the development of novel anti-inflammatory peptides that therapeutically target the chemokine netwo

259 s and correctly identified >75% of HLA-bound peptides that were observed experimentally in 11 patient

260 in-based vaccine that included six Strep A M peptides that were predicted to elicit antisera that wou

261 esized, given the flexibility of SH3 binding peptides, that their binding pathways include multiple s

262 udies were initially limited to simple model peptides, the past decade has seen a dramatic advancemen

263 uctural variability of natural and synthetic peptides, the two directions have so far not been merged

264 ws that, in the presence of palmitoleoylated peptides, these glypicans change conformation to create

265 he coating facilitated the mass transport of peptides through the PAN layer, thus enabling extraction

266 ew handle for site-selective fluorination of peptides, thus installing a specific probe to study pept

267 ontaining and UV-reduced cysteine-containing peptides to be identified by a nontargeted database sear

268 We used a set of natural peptides to explore the specificity of dissolved extrace

269 iderably decreases the adsorption of certain peptides to glass.

270 cs made by phospholipids and amphipathic 18A peptides to mediate the formation of supported phospholi

271 This demonstrates the potential of small peptides to neutralize lethal snake toxins in vitro, est

272 we study adhesion of Lys and DOPA-containing peptides to organic and inorganic substrates using singl

273 a computational approach to design bicyclic peptides to target specific epitopes on disordered prote

274 oemission spectroscopies, bonding of the two peptides to TiO(2) surfaces (either nanostructured or si

275 ow that after relaxation of the photoexcited peptides toward the minimum of the different npai* state

276 We identify six antimicrobial peptides, two plant immune regulators and eight chemical

277 detection and identification of cross-linked peptides using multistage mass spectrometry (MS(n)).

278 ated as the separation media for analysis of peptides using supercritical fluid chromatography-mass s

279 tended monomers at the N- and C- terminus of peptides using wild-type and engineered ribosomes.

280 matrix, the median LOD and LOQ for cytokine peptides was 130 and 433 pg/mL, respectively.

281 ticular, the proline/glycine kink in helical peptides was reported to both increase and decrease anti

282 approaches for the discovery of therapeutic peptides, we present a method for the isolation of small

283 channels, using specific S4-S5(L)-mimicking peptides, we previously demonstrated that S4-S5(L)/S6(T)

284 fferent class I alleles and greater than 800 peptides, we systematically and comprehensively mapped s

285 Among the identified peptides were ACE-inhibitory peptides (LDAQSAPLR, LKGYGG

286 noted that these 1:1 alpha/Sulfono-gamma-AA peptides were completely resistant to proteolytic degrad

287 At least four of the five selected surrogate peptides were detected in nine of the products analyzed,

288 Two or more pathogen peptides were identified in 40% of samples from PTLDS an

289 Three of these peptides were purified and their structures elucidated b

290 IgE and IgG4 levels to selected peptides were quantified using ImmunoCAP.

291 Twelve candidate peptides were selected as potential authentication marke

292 nucleoprotein were digested and proteotypic peptides were selected for parallel reaction monitoring

293 The synthesized peptides were tested for their binding to nSH3/cSH3.

294 unds, representative of mono- and disulfated peptides, were used to compare the enrichment capabiliti

295 identified 53 differentially phosphorylated peptides when comparing low responders with high respond

296 n of the Toll pathway-mediated antimicrobial peptides when the flies were challenged with Gram-positi

297 ts, a class of Bronsted basic guanidinylated peptides, which catalyze an efficient atroposelective ch

298 Peptides with molecular weights from 12 to 35 kDa, with

299 Peptides with the right properties, for example Antimicr

300 omeostatic control, and express insulin-like peptides with well-established roles in regulating food

301 The caveat is that modified peptides would need to reliably contain only a single O-