ライフサイエンスコーパス: peptidic

1 ral energies are spatially controlled within peptidic 1-D nanostructures to create localized energy g

2 derivative of acetazolamide, a spacer, and a peptidic (99m)Tc chelator, was labeled using sodium pert

3 ancer cells can process and present a shared peptidic Ag to TCR alphabeta+ T cells via a nonclassical

4 As such, many peptidic agents have been described in the past decade,

5 the delta receptor by centrally administered peptidic agonists and intravenously administered JOM-13

6 ects without producing convulsions, and some peptidic agonists can increase BDNF mRNA expression, how

7 Using total synthesis, we found that the peptidic alkaloid tryptorubin A can be one of two noncan

8 n of VEK-30 with mK2Pg demonstrated that the peptidic alpha-helical structure increased substantially

9 Peptidic alpha-toxins AahI to AahIV are responsible for

10 When homologous peptidic amide and ester substrates were compared, a ser

11 ould be exploited for the development of non-peptidic amyloid-specific inhibitors.

12 own approach to study a series of alpha/beta-peptidic analogs of anginex, a beta-sheet-forming antian

13 Other peptidic analogues, chosen because of specific substitut

14 quantitation of translation termination and peptidic analysis identified lncRNAs that produce peptid

15 ernalized DRM proteins show varied lipid and peptidic anchors indicating that, contrary to the prevai

16 nce for overlapping ligand-binding sites for peptidic and nonpeptidic agonists.

17 It also competes weakly with peptidic and nonpeptidic antagonists.

18 Thus, the CSP approach distinguishes both peptidic and nonpeptidic delta opioid agonists and antag

19 ned models for a structurally diverse set of peptidic and nonpeptidic delta opioid ligands offer good

20 In addition, results indicate that both peptidic and nonpeptidic ligands have the same binding m

21 Because of its critical role in cancer, many peptidic and nonpeptidic ligands with different modes of

22 access to folded objects beyond the reach of peptidic and nucleotidic backbones.

23 have relevance for the development of other peptidic and peptidomimetic drugs such as inhibitors of

24 Peptidic and peptidomimetic hydroxamates are increasingl

25 jor progress has recently been achieved with peptidic and proteinaceous compounds.

26 A variety of peptidic and proteinaceous contaminants (e.g., proteins,

27 o binding of Tat protein and of a variety of peptidic and small molecule ligands, indicating that its

28 ps, and latest updates of the development of peptidic and small molecule NPFFR ligands as tool compou

29 es a platform for the further development of peptidic and/or small molecule agents directed toward th

30 notoxin GVIA, a well-characterized ICK-motif peptidic antagonist of voltage-gated calcium channels.

31 caconitine, further opens to accommodate the peptidic antagonist, alpha-conotoxin ImI, but wraps arou

32 e recent development of orally available non-peptidic antagonists and genetically modified mice defic

33 I and class II molecules bind to and display peptidic antigens acquired from pathogens that are recog

34 riant T (MAIT) cells recognize microbial non-peptidic antigens presented by non-classical MHC MR1.

35 ructural relationships with other classes of peptidic antimicrotubule agents, or for modeling studies

36 mode of HTI-286, a synthetic analogue of the peptidic antimitotic agent hemiasterlin, to tubulin is p

37 Many peptidic APIs are large molecules that require considera

38 translocation signal is comprised of unique, peptidic (approximately equal to 40-aa) sequences.

39 These peptidic arrays are used to purge self-reactive T cells,

40 ts for human Cdc25A with respect to a set of peptidic, artificial, and natural substrates.

41 To date, a large number of peptidic as well as nonpeptidic SH2 domain inhibitors ha

42 Second, B cells specific to the peptidic B cell epitope in pCol(28-40) were absent among

43 that the anti-GBM Ab was not related to the peptidic B cell epitope nested in pCol(28-40); that is,

44 array of oligomannose glycans on Env shields peptidic B cell epitopes, impedes the presentation of T

45 ACE1 for activity and inhibition by selected peptidic BACE inhibitors.

46 n-2-ylamine], the first orally available non-peptidic BACE1 inhibitor that produces profound Abeta-lo

47 sure to UV light induces an oxidation of its peptidic backbone and a concomitant reduction of the coo

48 multaneously improved by replacing the polar peptidic backbone of the inhibitor with nonpeptidic moie

49 lator natural product, which contains in its peptidic backbone two S-methylated l-cysteine residues.

50 Here we report a new type of unnatural peptidic backbone, containing alpha-, beta-, and gamma-a

51 sful biologics to date are drugs that bear a peptidic backbone, ranging from small peptides to monocl

52 y-D-glucitol-gamma-glutamate subunits into a peptidic backbone, was synthesized.

53 are seen also in helices formed by unnatural peptidic backbones, e.g., those containing beta- or gamm

54 e 1 were conceived as "minimalist" mimics of peptidic beta-turn structures.

55 t reported crystal structure of a two-tailed peptidic bilayer reveals similarities in thickness to a

56 , a strategy for the iterative conversion of peptidic blockers of protein-protein interactions into p

57 the A' pocket of the groove, whereas its two peptidic branches protrude along the F' pocket to the ou

58 ers of 4-hydroxyphenylglycine as non-natural peptidic building blocks synthesized via a copper-comple

59 We investigated the effect of the peptidic C3 inhibitor, compstatin Cp40, and its long-act

60 n amine-containing PS forms amide bonds with peptidic cargo, a thiol derivative is designed for conju

61 specific bone fracture targeting of multiple peptidic cargoes can be achieved by subcutaneous injecti

62 conjugation of a small receptor ligand to a peptidic carrier to potentially facilitate transport acr

63 f as little as 0.1 mol % of a chemoselective peptidic catalyst.

64 ort peptides, the design and optimization of peptidic catalysts by rational structural modifications

65 In recent years, numerous versatile peptidic catalysts have been developed that bear Xaa-Pro

66 stereoselectivity of H-Pro-Pro-Xaa-NH2-type peptidic catalysts in conjugate addition reactions.

67 diastereoselectivity of structurally related peptidic catalysts.

68 ool to optimize the catalytic performance of peptidic catalysts.

69 radiography and compared with an established peptidic CCK agonist radioligand.

70 rom these studies revealed not only that the peptidic CCK2R ligands were unstable in vivo but also th

71 o acid residues of 1 with moieties with less peptidic character was done with retention of BACE enzym

72 ncy of this lead, as well as attenuating its peptidic character, an analogue program was undertaken.

73 h higher conformational definition and lower peptidic character.

74 and KGHK-Rev, which also contain N-terminal peptidic chelators (ATCUN motifs), were studied for comp

75 activity can be conveniently monitored with peptidic chromogenic or fluorogenic substrates, with cer

76 e site specificity (PICS), we identified 286 peptidic cleavage sites spanning from P6 to P6' from whi

77 stent with the kinetic data, the affinity of peptidic competitive inhibitors is diminished at acidic

78 ows LN01 to interact simultaneously with the peptidic component of the MPER epitope and membrane via

79 hese studies yield new insight into critical peptidic components composing one side of the prion repl

80 and robustly with PrP(Sc), likely represent peptidic components of one flank of the prion replicativ

81 Defensins are peptidic components of the innate immune system of plant

82 d was specific for structure of the acyl and peptidic components of these antigens.

83 of 70.37%, was characterised in terms of its peptidic composition using mass spectrometry and 1882 pe

84 This peptidic compound, termed LirAzo, possesses an azobenzen

85 These peptidic compounds and their advantageous biological pro

86 have constructed and tested a library of 45 peptidic compounds based on this loop sequence.

87 LACE as an effective strategy for converting peptidic compounds to more pharmaceutically relevant com

88 (including apamin, scyllatoxin and newer non-peptidic compounds) showed these homomeric SK3 channels

89 ity, nonreceptor-mediated interaction of the peptidic conantokins with synaptic membranes in conjunct

90 can introduce unnatural amino acids and non-peptidic constraints that modify peptide backbones and s

91 ally-produced, post-translationally modified peptidic copper-binding natural products produced under

92 t a study on MMP-12 inhibitors with a common peptidic core but different ZBGs.

93 ss-section EM to reveal a nanostructure with peptidic core.

94 pharmacokinetic properties relative to their peptidic counterparts.

95 cleoside amino acid fragment was followed by peptidic coupling of the two components, leading to the

96 onalized pyrolytic graphite electrodes using peptidic coupling.

97 r antagonist, and alpha-helical CRH(9-41), a peptidic CRHR1/CRHR2 antagonist to attempt to determine

98 Previously documented peptidic cross-linking strategies remain operative in th

99 and the synthesis of our first series of non-peptidic cyclophilin ligands, along with the preliminary

100 D-responsive IKZF3 degron and show that this peptidic degron can be used to target heterologous prote

101 present study examined whether a variety of peptidic delta agonists, DPDPE, JOM-13, a systemically a

102 review summarizes the stepwise evolution of peptidic dendrimers along with their multifaceted applic

103 novel chemotype of potent small-molecule non-peptidic dengue protease inhibitors derived from 4-benzy

104 TEEI (4), VYGGG (5), and YGFGG (6) to afford peptidic derivatives for exploring pentapeptide-based hy

105 process and convert exogenous antigens into peptidic determinants capable of interaction with MHC cl

106 This minor peptidic difference results in the induction of two comp

107 own to be very efficacious at insertion into peptidic disulfide bonds.

108 cerning the rate by which TCEP reduces other peptidic disulfide bonds.

109 s an engineered nanocontainer for delivering peptidic drugs across the BBB encapsulating the analgesi

110 ffector molecule, resembles the mechanism of peptidic entry inhibitors based on portions of the gp41

111 tion of gluten and gliadin 33-mer equivalent peptidic epitopes (33EPs) in human feces.

112 at combination of NP-inspired scaffolds with peptidic epitopes enables identification of novel hot lo

113 cificities and may hydrolyze a wide range of peptidic epitopes; it is therefore challenging to identi

114 oach can become a tool for rapid creation of peptidic expression domains in a eukaryotic environment.

115 ioid receptors, for which relatively few non-peptidic fluorescent probes currently exist.

116 In this respect, peptidic foldamers are perhaps the best-characterized sy

117 We describe efforts to develop peptidic foldamers that bind to the irregular receptor-r

118 Peptidic foldamers, consisting of various amino acid bas

119 mes to stabilize the folding in a variety of peptidic foldamers.

120 bundles composed of either alpha-peptides or peptidic foldamers.

121 The peptidic fraction of carotenoproteins (PFCP) contained 8

122 s and in vitro antioxidative activity of the peptidic fraction of carotenoproteins from shrimp (Parap

123 Results from this study suggest that the peptidic fraction of carotenoproteins is a good source o

124 rties of Pacific hake hydrolysates and their peptidic fractions varying in molecular size were assess

125 (procyanidin B3) and different wheat-derived peptidic fractions.

126 is stabilized by hydrogen bonds between the peptidic fragment and the sugar.

127 restrictive properties of media differing in peptidic fragment content and reveal unusual signalling

128 markedly enhanced production of informative peptidic fragment ions during CID that dramatically incr

129 were obtained for isolated protein domains, peptidic fragments, or mutants.

130 with MALDI-TOF MS analysis of the resulting peptidic fragments.

131 can be widely used to improve the potency of peptidic fusion inhibitors against other enveloped virus

132 cretagogue receptor 1a (ghrelin receptor), a peptidic G-protein-coupled receptor.

133 The therapeutic success of peptidic GLP-1 receptor agonists for treatment of type 2

134 Peptidic glucagon antagonists have been shown to lower b

135 rity to lipidic GPCRs than to the homologous peptidic GPCRs.

136 All peptidic guests in all solvent systems have association

137 Macrocyclization could also provide a less peptidic HCV inhibitor.

138 ins DS40M6 and DS40M8, each contain a unique peptidic head group that coordinates iron(III) and an ap

139 tin has the same Tris-hydroxamate-containing peptidic headgroup composed of three ornithine residues

140 uretic peptides (PNPs), are a novel class of peptidic hormones that signal via guanosine 3',5'-cyclic

141 No specific peptidic hydrolysed bond was detected.

142 acterize the engagement of hTS with one such peptidic inhibitor in cell lysates.

143 A peptidic inhibitor of caspase-3, Z-Asp-Glu-Val-Asp-fluor

144 nerated viruses with resistance to VIR165, a peptidic inhibitor that binds the fusion peptide of the

145 The non-peptidic inhibitor tipranavir is distinctive in its cons

146 A synthetic peptidic inhibitor, diphenyl N alpha-benzoxycarbonyl-l-A

147 Recently, we successfully developed a peptidic inhibitor, RRYGTSKYQ ("SKY" peptide), that show

148 association of acetylcholinesterase with its peptidic inhibitor, the neurotoxin fasciculin.

149 The potent peptidic inhibitor, Y1, of the basic residue-specific ye

150 The designed peptidic inhibitors are 12-amino-acids-long and target t

151 the importance of evaluating the potency of peptidic inhibitors at physiologically relevant pH value

152 Here we design small peptidic inhibitors based on the atomic structure of the

153 in-coupled receptors, for which chemical and peptidic inhibitors have been extensively explored, few

154 experimental approach and identify novel non-peptidic inhibitors of CK2 subunit interface disclosing

155 vel substrates and their conversion into non-peptidic inhibitors of Cys and Ser proteases.

156 esis and in vitro characterization of potent peptidic inhibitors of dengue virus protease that incorp

157 We recently discovered new, unconventional peptidic inhibitors of hTS that are active against cance

158 Potent and selective non-peptidic inhibitors of human endothelin-converting enzym

159 gn and structural characterization of potent peptidic inhibitors of influenza hemagglutinin.

160 e of action of Elec410 as one of the largest peptidic inhibitors targeting the acetylcholinesterase p

161 benzamide, belongs to a family of potent non-peptidic inhibitors that have large P1' groups.

162 y demonstrates the feasibility of developing peptidic inhibitors to functionally relevant sites on PC

163 Using this assay, we found that the peptidic inhibitors, leupeptin and aprotinin, exhibited

164 y classified as either peptidomimetic or non-peptidic inhibitors.

165 to give irreversible cruzain inhibition for peptidic inhibitors.

166 as a starting structure to rationally design peptidic inhibitors.

167 ied structurally diverse small molecule (non-peptidic) inhibitors (SMNPIs) of the botulinum neurotoxi

168 re were employed to mine small molecule (non-peptidic) inhibitors from the National Cancer Institute'

169 nd a domain motion enabling enclosure of the peptidic ligand and formation of specific hydrogen bonds

170 The APJ receptor and its endogenous peptidic ligand apelin have been implicated as important

171 conjugate that consists of a nanobody and a peptidic ligand for a G protein-coupled receptor (GPCR),

172 in was recently identified as the endogenous peptidic ligand for human APJ.

173 n vitro potency to apelin-13, the endogenous peptidic ligand for the APJ receptor.

174 r, expressed in an inducible manner, and the peptidic ligand substance P was used as a test system.

175 that targets the ATP-binding cleft and (2) a peptidic ligand that enhances selectivity between kinase

176 e that QDC-3DM can be applied to analyze any peptidic ligand to reveal single-cell correlations betwe

177 settled in the apo-cluster and the PR-957 (a peptidic ligand) complex in the pep-cluster.

178 he potency of a recently described linear SE peptidic ligand.

179 subunits of the unliganded species with the peptidic liganded forms demonstrates a greatly enhanced

180 The manner by which peptidic ligands bind and activate their corresponding G

181 Peptidic ligands can be used for specific cell targeting

182 In contrast, peptidic ligands failed to promote expression or rescue

183 ve biopanning for isolation of high affinity peptidic ligands for a single cancer type and expands th

184 One of the better characterized peptidic ligands is the chemotactic cytokine complement

185 r phylogeny has accelerated the discovery of peptidic ligands targeted to ion channels and receptors.

186 pioid efficacy pharmacophore, is extended to peptidic ligands using replica exchange molecular dynami

187 and the pep-cluster comprises complexes with peptidic ligands.

188 residues is compared with that of biotin and peptidic ligands.

189 iopanning for the isolation of TM transiting peptidic ligands.

190 H1-hinge domains of mAb2 are fused through a peptidic linker to the N terminus of mAb1 H chain, and p

191 the latter, the two peptides are joined via peptidic linkers of variable lengths to produce a range

192 glycosidic attachment of thymine at C-1, and peptidic linking of the C-6 amine with the 1,2-aminocycl

193 peptides proved efficient in the ligation to peptidic, lipidic and fluorescently labeled amines and i

194 rapeutic potential and mode of action of the peptidic macrocycle CXCR4 antagonist POL5551 in mice wit

195 cule modulators of CXCR7 have been reported, peptidic macrocycles may provide advantages in terms of

196 We produced a series of peptidic macrocycles that incorporate an N-linked peptoi

197 ilico three-dimensional library of composite peptidic macrocycles.

198 ning the activity and physical properties of peptidic macrocycles.

199 ate and selectively redissolve CS versus the peptidic material and (3) the selective purification and

200 Administration of peptidic MC4R antagonists (usually by intracerebro ventr

201 alternatives, we replaced one or both of the peptidic membrane anchors of exocytic vesicle (v)- and t

202 ndocaensis results in the discovery of three peptidic metabolites (cahuitamycins A-C), with cahuitamy

203 effectively mine microbial strains for novel peptidic metabolites.

204 These results suggest that all peptidic mimics of Tat induce the same dynamics in TAR w

205 talling isosteric chemical substituents in a peptidic model system and using NMR spectroscopy, X-ray

206 ligands linking agonist to antagonist small peptidic moieties were designed and found to act as Galp

207 of the myristoyl chain and repulsion of the peptidic moiety from the phospholipid headgroup region.

208 a1-selective peptidomimetic, or an RGD/PHSRN peptidic molecule.

209 As peptidic molecules find increasing value in therapeutic

210 e energy associated with the transfer of the peptidic molecules from water to membrane.

211 ade to develop technologies for selection of peptidic molecules that act as substrates or binders to

212 tide-binding domains (PBDs) and unstructured peptidic motifs in partner proteins.

213 o link the acids to DNA major groove-binding peptidic motifs known to adopt alpha-helical conformatio

214 xylation of conserved prolyl residues within peptidic motifs present in the HIFalpha family members.

215 second and fourth amino acid residues in the peptidic mu opioid lead agonist Dmt-d-Arg-Phe-Lys-NH(2)

216 Herein, we used a self-assembling peptidic nanoparticle (NP) platform featuring a cell pen

217 s, we show that intraarticular delivery of a peptidic nanoparticle complexed to NF-kappaB siRNA signi

218 This peptidic natural product exhibited an amino acid sequenc

219 e various bioactivity types and potencies of peptidic natural products (PNPs) are of high interest fo

220 A number of seemingly structurally disparate peptidic natural products inhibit tubulin polymerization

221 y towards high-throughput discovery of novel peptidic natural products.

222 nvironmental responsiveness, morphology, and peptidic nature make this hydrogel a possible material c

223 The peptidic nature of pantocin B facilitated a series of st

224 The peptidic nature of the calmodulin ligand enables incorpo

225 lic dipeptide moiety would also decrease the peptidic nature of the inhibitors.

226 ochemistry was employed to detect changes in peptidic neurotransmitter expression in identified dural

227 amics simulations were performed with 13 non-peptidic neurotransmitters (NTs) in three different memb

228 methylmalonyl CoA is hydrogen bonded to the peptidic NH group of Gly 110 and the imidazole ring of H

229 The oxyanion hole, formed by peptidic NH groups from Gly121, Gly122, and Ala204, is a

230 d between the carbonyl oxygen of ACh and the peptidic NH groups of Gly121 and Gly122.

231 the inhibitors are mediated through backbone peptidic NH groups, carbonyl oxygens, and/or solvents.

232 gen bonds with backbone carbonyl oxygens and peptidic NH groups.

233 that the stimulatory compounds were neither peptidic nor lipidic but instead were composed of sulfur

234 We synthesized a series of peptidic NPY Y(4)R ligands, derived from the hexapeptide

235 structure prediction and design of five non-peptidic oligomer scaffolds (noncanonical backbones), ol

236 Peptidic oligomers that contain both alpha- and beta-ami

237 The peptidic opioid delta(1) agonist [D-Pen(2),D-Pen(5)]enke

238 ibitors relies on a core zinc chelator and a peptidic or nonpeptidic scaffold that provides supplemen

239 letely novel set of antibacterial compounds, peptidic or peptidomimetic, if the interacting bacterial

240 is first halogenated and then elaborated by peptidic or polyketide extensions.

241 ecule that occupies the same position as the peptidic oxygen in the tetrahedral intermediate.

242 OSCA1.3 within minutes of treatment with the peptidic PAMP flg22, which is derived from bacterial fla

243 On the contrary, we identified the non-peptidic part as the determining factor of differences b

244 were capable of localizing small amounts of peptidic payloads to fracture surfaces 2-fold over healt

245 n classes of rhodesain inhibitors, including peptidic, peptidomimetic, and nonpeptidic structures, em

246 zed by conjugating fluorescent dyes to a non-peptidic, pharmacophore-based ligand, based on a molecul

247 alpha,beta-unsaturated ketones catalyzed by peptidic phosphine ligands and (CuOTf)(2).C(6)H(6).

248 ric acids and (b) phosphothreonine-embedded, peptidic phosphoric acids.

249 ligand can bind simultaneously to a flexible peptidic PPI recognition motif and to a well-structured

250 downregulation in cancer cells by designing peptidic precursors as the substrates of both carboxyles

251 ) in complex with a substrate analogue and a peptidic product to 2.5 and 2.7 A, respectively, and com

252 A similar configuration was evident for the peptidic product, although decreasing electron density t

253 ompared efficacy and safety of the novel non-peptidic protease inhibitor tipranavir co-administered w

254 a well-known family of aldehyde-containing, peptidic protease inhibitors, including antipain, chymos

255 fluence of (EH)3 on the biodistribution of 2 peptidic radiopharmaceuticals, Glu-urea-Lys(Ahx)-HBED-CC

256 to improve the pharmacokinetic properties of peptidic radiopharmaceuticals, leading to reduced uptake

257 Here we investigate the ability of such peptidic receptor ligands to target the liver.

258 and their bioderivatization with a selective peptidic receptor modified with a SERS transducer.

259 potential to interact with broad surfaces of peptidic receptors rather than within their narrow folds

260 Boronic acid based peptidic receptors, derived from a combinatorial library

261 we biochemically generated the potential Tg peptidic repertoire available to HLA-DR3 by separately t

262 ot affect the binding of the four C-terminal peptidic residues to PDZ, as revealed by the crystal str

263 he catalytic domain of human MMP9 bound to a peptidic reverse hydroxamate inhibitor as well as the co

264 The introduction of non-peptidic scaffolds into macrocycles is highly desirable

265 unit of the ligand and the AA2 moiety of the peptidic segment of the chiral ligand associates and del

266 yields highly conjugated backbones when the peptidic segment of the PAs has a linear, as opposed to

267 , we further identified within this region a peptidic segment that exhibits membrane interaction prop

268 olism through their binding, via a conserved peptidic sequence, into a universally conserved pocket.

269 A discrete peptidic sequence, termed the amyloid-converting motif (

270 pine nucleus is introduced internally to the peptidic sequence.

271 rupting the DNA stretch encoding a conserved peptidic sequence.

272 s of beta-sheet folding and design for alpha-peptidic sequences are well established, while those for

273 ere, we used phage display to identify novel peptidic sequences that bind Cx43CT and modify Cx43 regu

274 s further exemplified in combining optimized peptidic sequences with effective N-terminal capping gro

275 novo-designed bioactive beta- or alpha,beta-peptidic sequences.

276 dels or, as in previous studies, zinc finger peptidic sequences.

277 the membrane permeability of matched sets of peptidic small molecules bearing natural or bioisosteric

278 Our approach relies on the use of non-peptidic small molecules, which selectively bind fungal

279 inus of VEK30 (VEK32) maintained a monomeric peptidic structure, but exhibited similar K2hPg binding

280 eation of rationally designed and functional peptidic structures, the roles of these forces on purely

281 proteolysis rate of the folded protein and a peptidic substrate mimicking the sequence at the cleavag

282 iabetic compound such a the organic vanadate peptidic substrate was possible the toxicity problems cu

283 Ligand interactions, as reported in one peptidic substrate, are favorable so that complementarit

284 ic phosphate derivatives, the more realistic peptidic substrates allow evaluating substrate specifici

285 employing 3-nitrophosphotyrosine containing peptidic substrates is described.

286 ytic efficiency than glycan-free KLK2 toward peptidic substrates with P2-Phe, the situation was rever

287 nown to process a large variety of different peptidic substrates, although the mechanism behind this

288 ng enzyme (IDE) cleaves insulin, among other peptidic substrates, but its function in insulin signali

289 In contrast to peptidic substrates, Cdc25A and dN25A are highly active

290 ction from 3-nitrophosphotyrosine containing peptidic substrates, which are accepted by many PTPs.

291 atases-tailoring the number of phosphates on peptidic substrates-is able to regulate the rate of mole

292 aturation and are capable of acting on large peptidic substrates.

293 onfirms a mode of binding similar to that of peptidic substrates.

294 e show that gp33 variants substituted at the peptidic termini at the putative CDR1 contact regions sh

295 e and robust synthesis of highly substituted peptidic thiazole derivatives using Ugi-multicomponent r

296 ctivating regions characterized thus far are peptidic, this function can be served by other kinds of

297 , it is likely that the discovery of similar peptidic toxins will rapidly expand to existing and emer

298 other sequence suggesting an expansive short peptidic transport system within Devosia.

299 f novel, potent, selective, and short-acting peptidic V(2)R agonists, we synthesized a series of C-te

300 h 7 daily subcutaneous injections of VIPhyb (peptidic VIP-antagonist) or phosphate-buffered saline (P