ライフサイエンスコーパス: perforant path

1 inal input to the ipsilateral dentate gyrus (perforant path).

2 erlap and interact with innervation from the perforant path.

3 arizations in response to stimulation of the perforant path.

4 paired-pulse paradigm was determined in the perforant path.

5 tial after high-frequency stimulation of the perforant path.

6 nduced through electrical stimulation of the perforant path.

7 it was restricted to synapses of the lateral perforant path.

8 dopaminergic control of transmission in the perforant path.

9 stimulation (HFS) was applied to the medial perforant path.

10 ves input from the entorhinal cortex via the perforant path.

11 perforant path projections, but not lateral perforant path.

12 uated in rats kindled from olfactory bulb or perforant path.

13 escence on glutamatergic axons of the medial perforant path.

14 ols indicating atrophy at this branch of the perforant path.

15 the parahippocampal gyrus that includes the perforant path.

16 ls prepared with bilateral knife cuts of the perforant path, a major afferent hippocampal fiber bundl

17 ion predict that blocking mossy-fiber and/or perforant path activity to CA3 would cause impairments i

18 revealed that high-frequency stimulation of perforant path afferents induced a robust STP and LTP of

19 separating the associational/commissural and perforant path afferents.

20 ating and recording electrodes placed in the perforant path and dentate gyrus, respectively.

21 mals prepared with chronic electrodes in the perforant path and dentate gyrus.

22 in cortical interneurons, in the hippocampal perforant path and mossy fiber pathways, and in the glob

23 ia a decrease in glutamate release from both perforant path and mossy fiber terminals.

24 ed on the established importance of both the perforant path and N-methyl-D-aspartate (NMDA) receptors

25 nputs to hippocampal CA1 neurons through the perforant path and Schaffer collateral synapses, respect

26 atrophilin-3 selectively direct formation of perforant-path and Schaffer-collateral synapses, respect

27 Synaptic input from granule cells (GCs), perforant path, and CA3 inputs onto hilar border interne

28 he associational-commissural pathway, medial perforant path, and lateral perforant path, respectively

29 tribution of the main excitatory inputs, the perforant path, and Schaffer collaterals during theta an

30 ing, we quantified both the integrity of the perforant path as well as dentate/CA3 dendritic changes

31 nd among somatostatin (SOM)-containing hilar perforant path-associated (HIPP) interneurons.

32 rbours were contained within the SO; and one perforant path-associated cell with axonal and dendritic

33 Hilar-perforant-path-associated interneurons (HIPP cells) have

34 high frequency (400 Hz) train bursts to the perforant path at a moderate stimulus intensity and I/O

35 nesthetized rats and with stimulation of the perforant path at the peak of theta in both anesthetized

36 vels in entorhinal cortex neurons, where the perforant path axons originate, were stable through adul

37 (1) the middle molecular layer (MML), where perforant path axons synapse with dentate granule cells,

38 n by increasing afterdischarge thresholds in perforant path (but not olfactory bulb) kindling and cau

39 paired long-term potentiation in the dentate perforant path, but not in the CA1 Schaffer collateral p

40 tic input from the entorhinal cortex via the perforant paths, but this input was differentially sensi

41 ring extrinsic CA3 inputs, whereas extrinsic perforant path-CA3 synaptic inputs are attenuated on CA3

42 by high-frequency stimulation of the medial perforant path carried out on each of 4 consecutive days

43 The perforant path carries place and spatial information tha

44 duces long-term synaptic potentiation of the perforant path connection to granule cells of the dentat

45 QX impaired fast excitatory transmission, at perforant-path dentate gyrus synapses in the dorsal hipp

46 so, long-term potentiation was attenuated in perforant path-dentate granular cell synapses.

47 induction of long-term potentiation (LTP) at perforant path-dentate granule cell synapses in ovariect

48 with the heightened B-AR function at medial perforant path-dentate granule cell synapses that is res

49 long-term potentiation (LTP) is deficient at perforant path-dentate granule cell synapses.

50 deficits in long-term potentiation at medial perforant path-dentate granule cells synapses in FX mice

51 nly studied Schaffer collateral synapses and perforant path-dentate gyrus (DG) synapses of the hippoc

52 synapses, significantly less is known about perforant path-dentate gyrus (DG) synapses.

53 pal Schaffer collaterals (SC)-CA1 and medial perforant path-dentate gyrus (mPP-DG) synapses in juveni

54 CK increased AMPA receptor-mediated EPSCs at perforant path-dentate gyrus granule cell, CA3-CA3 and S

55 f hippocampal excitability revealed enhanced perforant path-dentate gyrus long-term potentiation (LTP

56 tiation (LTP) could be induced at the medial perforant path-dentate gyrus synapse.

57 a selective impairment restricted to medial perforant path-dentate gyrus synapses of mutant mice.

58 cal role in the development of glutamatergic perforant path-dentate gyrus synapses, but not in common

59 NMDA receptor antagonist CPP on the decay of perforant path-dentate LTP.

60 Second, activation of CA1 neurons by the perforant path depends on the generation of dendritic sp

61 We also find that Tiam1's support of perforant path-DG synapse function is dependent on its G

62 ty (STP) and long-term potentiation (LTP) at perforant path-DG synapses in naive rats.

63 s, but neither LTP nor LTD was evoked at the perforant path-DG synapses.

64 hanisms that may confer unique properties to perforant path-DG synapses.

65 nonspatial (visual object) information from perforant path efferents in a unique manner that is cons

66 at a maximal stimulus intensity through the perforant path electrode, and input/output (I/O) functio

67 ferences were observed in characteristics of perforant path evoked field potentials or in paired puls

68 reduction in the conductance of polysynaptic perforant path-evoked fast and slow inhibitory postsynap

69 LTP of lateral perforant path-evoked field EPSPs was induced selectivel

70 to granule cells, paired-pulse depression of perforant path-evoked granule cell population spikes was

71 here was no post-traumatic alteration in the perforant path-evoked monosynaptic excitatory postsynapt

72 CG-IV also suppressed feedback inhibition of perforant path-evoked population spikes.

73 cts were not accompanied by major changes in perforant path-evoked responses or paired-pulse inhibiti

74 ntaneous synaptic events, and stimulation of perforant path fibers revealed direct, facilitating syna

75 synaptic potentials evoked by stimulation of perforant path fibers revealed increased excitatory tran

76 ed either by intermittent stimulation of the perforant path for 30 min (PPS) or by injection of lithi

77 cus (SSSE) in response to stimulation of the perforant path for periods too brief to have any effect

78 xcitability, and LTP induction in the medial perforant path-granule cell synapse of freely moving rat

79 or kappa) regulate LTP induction at lateral perforant path-granule cell synapses and (2) to test the

80 TP that can be sustained over days at medial perforant path-granule cell synapses in awake mice.

81 mined, we studied synaptic plasticity at the perforant path-granule cell synapses in the dentate gyru

82 g tests indicated that intact LTP at lateral perforant path-granule cell synapses is either redundant

83 der normal conditions, a single shock to the perforant path in a hippocampal slice typically drives a

84 te gyrus to stimulus pulses delivered to the perforant path in an ascending intensity series.

85 lices from untreated rats by stimulating the perforant path in the presence of bicuculline and 6 mM K

86 plasticity via electrical stimulation of the perforant path in vivo, MKRN1-short specifically accumul

87 ls to unilateral complete transection of the perforant path in vivo, we tracked these cells using tra

88 ssural projections following interruption of perforant path in Wlds mutant mice and in normal (C57BL/

89 The perforant path input (pp) is a major direct source of sp

90 cover a profound dysfunction of filtering of perforant path input by DG in young adult Scn1a(+/-) mic

91 Overall, these data show that the perforant path input from the entorhinal cortex to the D

92 ntate gyrus granule cells, which receive the perforant path input from the entorhinal cortex, relativ

93 fiber input from the dentate gyrus (DG), and perforant path input from the entorhinal cortex-that ter

94 t operations-across its multiple stages from perforant path input to CA1 output.

95 routing, which is homologous to the original perforant path input to the dentate gyrus of the hippoca

96 litation in field CA1 but not in the lateral perforant path input to the dentate gyrus.

97 s long-term potentiation (LTP) at the direct perforant path input to the distal dendrites of CA1 pyra

98 of the parahippocampal gyrus (origin of the perforant path input to the hippocampal formation in the

99 s triggered a long-lasting impairment of the perforant path input-output operation in epileptic denta

100 cal circuit alters information processing of perforant path inputs constituting the major excitatory

101 and also for the role of the mossy fiber and perforant path inputs to hippocampal area CA3.

102 asticity rule in which stimulation of distal perforant path inputs to hippocampal CA1 pyramidal neuro

103 dritic morphology, intrinsic properties, and perforant path inputs were similar to those of dentate g

104 his opioid modulation may enhance LTP at the perforant path inputs, potentially contributing to reinf

105 First, activation of CA1 neurons by the perforant path is limited, a result of the long distance

106 As the perforant path is severely affected in Alzheimer's disea

107 The perforant path is the principal route of entry from cort

108 These data suggest that perforant path kindling causes a persistent increase in

109 The present study examined the effects of perforant path kindling on 0-Mg(2+)-induced epileptiform

110 memory deficits in performance accompanying perforant path knife cuts.

111 deposits are dynamic structures and that the perforant path lesion alters the equilibrium between Abe

112 tate gyrus granule cells 2, 5, and 9 d after perforant path lesions.

113 ransmitter release at synapses in the medial perforant path linking stellate neurons located in layer

114 Perforant path long-term potentiation (LTP) in intact mo

115 d-dependent form of LTP expressed by lateral perforant path (LPP) input to the dentate gyrus (DG) was

116 and frequency following capacity by lateral perforant path (LPP) projections from lateral EC to dent

117 the dentate gyrus (DG) branch of the lateral perforant path (LPP) reduces paired-pulse facilitation,

118 ice, we have found that single-pulse lateral perforant path (LPP) stimulation produces a two-part CA1

119 and models, the manner in which the lateral perforant path (LPP) transforms signals from entorhinal

120 -commissural projections than in the lateral perforant path (LPP), an effect associated with distinct

121 The lateral perforant path (LPP)-dentate gyrus (DG) synapse operates

122 ion relayed to the structure via the lateral perforant path (LPP).

123 lded mossy cells as potentially critical for perforant path LTP and the GAP-43 in these cells as impo

124 ype and AC1 mutant mice exhibited comparable perforant path LTP recorded in the dentate gyrus as well

125 lease probability specifically of the medial perforant path (MPP) input to GC dendrites.

126 caused a long-lasting attenuation of medial perforant path (MPP) inputs to the young DGCs, but also

127 ng-dependent plasticity (STDP) of the medial perforant path (mPP) synapse onto dentate granule cells.

128 stinct information, i.e., medial and lateral perforant paths (MPP and LPP, respectively).

129 n field CA1 are not operative in the lateral perforant path: multiple lines of evidence indicate that

130 TrkB content were also reduced in the medial perforant path of 8- to 10-month-old rats.

131 of electrodes into the dentate gyrus and the perforant path of the hippocampus in vivo.

132 synapses on dentate granule cells but not at perforant path or associational-commissural synapses.

133 Stimulation of the perforant path or the commissural system was used to eli

134 ated hippocampus that incorporate either the perforant path or the trisynaptic loop.

135 Medial perforant path plasticity can be attenuated by 2-amino-5

136 aleric acid (APV) infusions, whereas lateral perforant path plasticity can be attenuated by naloxone

137 cortex contains the cells of origin for the perforant path, plays a critical role in memory processi

138 Theta burst stimulation of the perforant path potentiated responses throughout the mole

139 Stimulation of the MR 40 ms prior to perforant path (PP) activation significantly increased t

140 Amplitude and kinetics of IPSCs evoked by perforant path (PP) activation were not different betwee

141 cohippocampal excitatory connections between perforant path (PP) afferents and dentate granule cells

142 input from the entorhinal cortex through the perforant path (PP) and from CA3 through Schaffer collat

143 porally precise pairing of direct entorhinal perforant path (PP) and hippocampal Schaffer collateral

144 m the entorhinal cortex directly through the perforant path (PP) and indirectly through Schaffer coll

145 Perforant path (PP) axon terminals within the dentate gy

146 ibition with paired-pulse stimulation of the perforant path (PP) in vitro.

147 le effect on SC synapses, but suppresses CA1 perforant path (PP) inputs.

148 timing of inputs to hippocampal CA1 from the perforant path (PP) of the entorhinal cortex and the Sch

149 of CA1 and CA2 pyramidal neurons through the perforant path (PP) projection.

150 which the cortical excitatory drive from the perforant path (PP) recruits GABAergic interneurons that

151 the entorhinal cortex propagates through the perforant path (PP) to the molecular layer of the dentat

152 The perforant path (PP) undergoes synaptic changes in the co

153 itatory input from entorhinal cortex via the perforant path (PP), but the role of this cortical input

154 In wild-type mice, stimulation of the medial perforant path produced paired-pulse depression of inter

155 ized sensory input to the hippocampus is the perforant path projection from layer II of entorhinal co

156 The perforant-path projection to the hippocampus forms synap

157 Here we report that perforant path projections from layer II entorhinal cort

158 report that high frequency activation of the perforant path projections to the dentate gyrus causes n

159 High-frequency stimulation of the perforant path projections to the dentate gyrus, which t

160 targeted to synaptic sites by activating the perforant path projections to the dentate gyrus.

161 sociational-commissural afferents and medial perforant path projections, but not lateral perforant pa

162 Although there is detailed knowledge about perforant path projections, the functional synaptic prop

163 arriving at distal CA1 synapses through the perforant path provide compartmentalized, instructive si

164 The perforant path provides the primary cortical excitatory

165 pathway, medial perforant path, and lateral perforant path, respectively.

166 No changes in medial perforant path responses occurred.

167 Unilateral transection of the excitatory perforant path results in the acute deafferentation of a

168 w-frequency, single-shock stimulation of the perforant path revealed an early granule cell hyperexcit

169 vitro paired-pulse stimulation of the mixed perforant path revealed beta-estradiol-induced augmentat

170 tion of long-term potentiation in the medial perforant path, showing that the upregulated alpha4* rec

171 charge (AD) evoked from the dentate gyrus by perforant path simulation, whereas GalOE had increased t

172 mbria-fornix-transected (5 days), as well as perforant path-stimulated Sprague-Dawley rats fixed in 5

173 on of a single afterdischarge (AD) evoked by perforant path stimulation (0.1 ms pulse duration, 5 Hz,

174 ats undergoing self-sustaining SE induced by perforant path stimulation (PPS) at the ages of postnata

175 We examined the duration of intermittent perforant path stimulation (PPS) needed to induce self-s

176 (SSSE) induced in rats by brief intermittent perforant path stimulation (PPS) was examined with regar

177 , there was a decline in LTP in the DG after perforant path stimulation and impairment in contextual

178 creased the excitability of granule cells to perforant path stimulation both within and outside of th

179 a transient period during GC maturation when perforant path stimulation can generate a high probabili

180 Intermittent perforant path stimulation for 24 hours induced acute de

181 Here we found that perforant path stimulation in rat hippocampal slices evo

182 tials, paroxysmal discharges, were evoked by perforant path stimulation in the dentate gyrus of EL mi

183 al granule cells and enhanced the effects of perforant path stimulation in the ventral DG.

184 Recently, we reported in the perforant path stimulation model another neuroplastic ch

185 opensity to develop status epilepticus after perforant path stimulation or systemic kainic acid, as w

186 eaker paired-pulse inhibition in response to perforant path stimulation relative to suprapyramidal re

187 Although perforant path stimulation resulted in a larger [K+]o el

188 Induction of hippocampal seizure activity by perforant path stimulation resulted in an increase in SG

189 gyrus molecular layer in response to lateral perforant path stimulation was shifted to the left in hi

190 t, field potential responses to paired-pulse perforant path stimulation were obtained from the dorsal

191 ale offspring and field potentials evoked by perforant path stimulation were recorded from the dentat

192 6 months of age), field potentials evoked by perforant path stimulation were recorded in the dentate

193 As adults, field potentials evoked by perforant path stimulation were recorded in the dentate

194 nger-lasting depolarizations, in response to perforant path stimulation, in the presence of the GABAA

195 ged trains of action potential discharges to perforant path stimulation.

196 and loss of paired-pulse inhibition (29%) to perforant path stimulation.

197 mature brain from the excitotoxic affects of perforant path stimulation.

198 o granule cell layer stimulation but also to perforant path stimulation.

199 lt neurogenesis-reduced dentate responses to perforant-path stimulation and shifted EPSP-spike coupli

200 l recordings 5-16 d after seizure induction, perforant-path stimulation now evoked glutamatergic inpu

201 Intracellularly recorded responses to single perforant path stimuli also exhibited prolonged and larg

202 eature of the prolonged response to a single perforant path stimulus was a predominantly biphasic fie

203 esynaptic expression of HCN1 channels in the perforant path, suggesting that network activity contrib

204 tive mGluR2-mediated responses at the medial perforant path synapse and that this effect of forskolin

205 nels enhances the low efficacy of release at perforant path synapses by increasing the contribution o

206 naptic plasticity at Schaffer collateral and perforant path synapses in the hippocampus.

207 that the efficacy of transmitter release at perforant path synapses is lower than at Schaffer collat

208 Surprisingly, at perforant path synapses kainate receptor activation enha

209 netic induction of long-term potentiation at perforant path synapses of dentate gyrus engram cells re

210 r-dependent long-term potentiation at medial perforant path synapses onto dentate granule cells and d

211 iological role for presynaptic APP at medial perforant path synapses that may be adversely affected u

212 ng cold stress is not due to an inability of perforant path synapses to express LTP.

213 expression of long-term depression at medial perforant path synapses, increased granule cell and CA1

214 ion of glutamatergic inputs originating from perforant path synapses, resulting in reduced spike tran

215 tered excitatory neurotransmission at medial perforant path synapses, which was accompanied by transc

216 r collateral synapses but not of that of the perforant path synapses.

217 ion spike LTP and EPSP-spike potentiation at perforant path synapses.

218 now elicited frank LTD of synaptic EPSPs at perforant path synapses.

219 increased the neurotransmission efficacy at perforant path synapses.

220 firing output, and long-term potentiation of perforant path synapses.

221 2+) channels at the Schaffer collateral than perforant path synapses.

222 ior and experience-dependent modification of perforant path synaptic function through NMDAR activatio

223 abetes impairs hippocampus-dependent memory, perforant path synaptic plasticity and adult neurogenesi

224 ranule cell and pyramidal cell excitability, perforant path synaptic plasticity, and spatial memory.

225 Perforant path synaptic strength, measured in the in vit

226 on postsynaptic mechanisms regulating medial perforant path synaptic strength.

227 , but surprisingly not in granule cells, the perforant path target.

228 erved in a neuronal cell line and in lateral perforant path terminals naturally expressing mGlu2 and

229 ociated interneurons (n = 6) innervating the perforant path termination zone in stratum lacunosum-mol

230 icotine-induced synaptic potentiation of the perforant path that was found to underlie nicotine-condi

231 nels were localized to axon terminals of the perforant path (the major hippocampal afferent pathway)

232 originating from the entorhinal cortex (the perforant path, the alvear pathway, and the commissural

233 During a 1 Hz stimulus train applied to the perforant path, the magnitude and duration of the negati

234 med by the temporoammonic (TA) branch of the perforant path, the major cortical input to the hippocam

235 way, with little or no expression within the perforant path, the Schaffer collaterals, or neuronal ce

236 We showed that, at the perforant path to dentate gyrus (PP-DG) synapse, respons

237 uperficial entorhinal afferents (part of the perforant path) to dentate granule cells, dentate mossy

238 -term depression, are dysregulated at medial perforant path-to-dentate gyrus synapses of young Nse-Cr

239 e experiments revealed a reduced efficacy of perforant path transmission onto granule cells upon LFS.

240 In contrast, stimulation of the perforant path using patterns of stimulation that induce

241 spike, following tetanic stimulation of the perforant path, was observed in all strains.

242 bility elicited by stimulation of the medial perforant path, was obtained for each vigilance state at

243 tate gyrus in response to stimulation of the perforant path were assessed under urethane anesthesia.

244 ever, place units that were activated by the perforant path were prevalent in the model and were cruc

245 limits excitatory neurotransmission via the perforant path, which could be compromised in pathologic

246 as demonstrated by stimulation of the medial perforant path, which induced normal synaptic potentiati

247 Lesioning of the perforant path, which innervates the outer two-thirds of