ライフサイエンスコーパス: perfuse

1 We present a perfused 3D microtumour culture platform that sustains a

2 flow, while its concave well array hold and perfused 3D-cell constructs.

3 ion to triggering neuronal depolarization by perfusing a high-K(+) medium from the implanted MD probe

4 Since this site is well-perfused, a rapid dissemination of "fitter" clones may b

5 al and pulmonary arteries were synchronously perfused; a conventional approach, where only the pulmon

6 nd PLB [phospholamban]) was found in ex vivo perfused adult isolated hearts.

7 Langendorff-perfused adult Sprague-Dawley rat hearts were subjected

8 Bodies were perfused and CT images were acquired with limbs in the s

9 med over 4-5 d, after which the tumor can be perfused and extravasation events are easily tracked ove

10 In contrast, baseline-perfused and hypoperfused contacts mainly demonstrated n

11 etastatic tumour cells are exposed to highly perfused and immunoactive organs, such as the lungs.

12 ins in sensory neurons from rats with freely perfused and ligated femoral arteries: peripheral artery

13 Mice were perfused and sacrificed after the final PET scan, and ra

14 ealed that fibroid blood vessels were indeed perfused and stained with the lipophilic membrane dye; h

15 The donor intestines were either perfused and stored with inhibitor or had inhibitor admi

16 onia, and ex vivo upon treatment of isolated perfused and ventilated lungs with the purified bacteria

17 Quantification of leptospires in perfused animals revealed that pathogens were detected i

18 CBF and relative CBF in the most perfused area of each neoplasm and contrast enhancement

19 larger in hyperperfused compared to baseline-perfused areas.

20 ent and extended right lobe remained equally perfused, as demonstrated by Doppler ultrasound.

21 All the CAGs were well-perfused at 3 months.

22 rol probe), were made in each of five livers perfused at each flow rate.

23 All adjacent vessels remained perfused at follow-up.

24 The first 6 livers were perfused at high perfusate oxygen tensions, and the subs

25 ood (WB) and platelet-rich plasma (PRP) were perfused at high shear rates (> 3,000 s(-1)) through two

26 Similarly, human anterior segments perfused at higher flow rates released significantly mor

27 subsequent 6 liver transplants, with livers perfused at lower oxygen tensions, reperfused uneventful

28 Optical mapping of coronary-perfused atria (n=24) revealed that adenosine perfusion

29 An un-perfused balloon was used as a control.

30 sion (ESHP) preserves the donated heart in a perfused, beating condition preventing cold storage-rela

31 proof of concept study of an oxygenated and perfused bioreactor, we characterized the oxygenation of

32 To address this hypothesis, we perfused blood from healthy type O donors (n = 33) or no

33 duced endothelium supported the formation of perfused blood vessels in vivo.

34 elial maturation, and the highest density of perfused blood vessels.

35 We introduced dual-energy CT (DECT) perfused blood volume (PBV) as a PBF surrogate to evalua

36 Qualitative and quantitative analysis of perfused blood volume (PBV) maps recorded: i) perfusion

37 blocks 40% of cardiac capillaries and halves perfused blood volume within the affected region.

38 Analysis of the frontal white matter in perfused brains from the animals surviving 1-28 days aft

39 r pattern on phrenic and vagal nerves in the perfused brainstem preparation.

40 (3) of brainstem tissue in single arterially perfused brainstem preparations with respect to the ongo

41 In a third group, kidneys were perfused by HOPE for 1 hour after cold storage.

42 cted to the systemic vasculature as they are perfused by intravenously injected dye.

43 ent with the mathematical model, in coronary-perfused canine hearts, the addition of dofetilide (sele

44 Annular PCD (%) was defined as perfused capillary area divided by the corresponding ann

45 oncomitant mechanical overload improved both perfused capillary density and fatigue resistance (P<0.0

46 ts (ISEMFs) and endothelial cells (ECs) into perfused capillary networks.

47 O2 of 19-75 mmHg confirmed separation of the perfused CB circulation from the brain.

48 the outer retina nourished by the profusely perfused choroid.

49 In perfused cortical collecting ducts, secretin stimulated

50 tantially inhibited Na+ currents in isolated perfused cortical collecting tubules.

51 In addition, HOPE-perfused DCD livers achieved similar results as control

52 ine serum and 1% antibiotic-antimycotic) was perfused directly through each scaffold at low flow rate

53 ine serum and 1% antibiotic-antimycotic) was perfused directly through each scaffold at low flow rate

54 n (hirudin-like peptide [HLL]), which can be perfused directly to the donor organ or cells.

55 us VF optical mapping recordings of coronary perfused donor heart left ventricular wedge preparations

56 more closely, we integrated a 3D-bioprinted perfused drug screening microfluidics platform.

57 primarily manifests in vascular beds highly perfused during exercise, it has been postulated that in

58 poses a human mammary duct in proximity to a perfused endothelial vessel.

59 Here, we developed a vessel-on-a-chip with perfused endothelialized channels lined with human bone

60 while ischemically damaged human kidneys are perfused ex vivo for 24 hours.

61 dle acid once it is released into the poorly perfused extracellular space.

62 in elimination from the aqueous humor of the perfused eye was reduced 80% when novobiocin (0.1 mM) wa

63 post conception and then were transcardially perfuse fixed.

64 stress were assessed in healthy pig hearts, perfused for 12 hours either in nonworking mode (non-WM=

65 11.5 h (range 3.3-22.5 h) with one DCD liver perfused for 22.5 h.

66 One human kidney was EMS perfused for 24 hours (control), whereas its paired kidn

67 idneys with urine recirculation were readily perfused for 24 hours (n = 8) and exhibited physiologica

68 e reperfused with a protective solution then perfused for 4 hours with a novel oxygenated, nutrient-c

69 ed adult mouse hearts or cardiomyocytes were perfused for 5 minutes with the beta-AR agonist isoprote

70 ys, from the same donor, were simultaneously perfused for 7 hours.

71 HUVEC: PMN co-cultures were perfused for additional 15 minutes with PMN-free medium

72 All hearts were Langendorff-perfused for optical mapping with voltage- and Ca(2+)-se

73 We demonstrated that NaBu, alone or perfused from the UltraBraid+NaBu suture was pro-angioge

74 gic injury scores on POD8 were lower in both perfused groups (NEVKP and HAMP, score: 1-1.5) compared

75 We measured SFOAEs while perfusing guinea pig cochleas from apex to base with sal

76 arying the temperature at which the graft is perfused, have shown benefit in preclinical models and n

77 m and function were measured in the isolated perfused heart using radiolabelled substrates.

78 results suggest that in the healthy ex vivo perfused heart, HBP flux does not respond to acute chang

79 on (sulfination or sulfonation) in myocytes, perfused heart, or HEK cells.

80 Finally, using isolated-perfused hearts and in vivo hemodynamic and echocardiogr

81 isolated cardiac myocytes and in Langendorff-perfused hearts based on the use of the redox-sensitive

82 Optical mapping of perfused hearts confirmed slowed conduction on atria and

83 y in myocardium, but, surprisingly, isolated perfused hearts exhibited higher O2 consumption rates (O

84 METHODS AND We used isolated Langendorff-perfused hearts from control (CTL) and heart failure (HF

85 Isolated, perfused hearts from rats that were fed the ketone diet

86 Hemodynamic values of perfused hearts reached 60% or more those in the normal

87 y could be assessed within the myocardium of perfused hearts using NADH ED-FRAP.

88 hannels are activated to a greater extent in perfused hearts when the LV performs pressure-volume wor

89 In isolated, perfused hearts, energetics were measured using (31)P ma

90 For both Langendorff-perfused hearts, the calculated epicardial and endocardi

91 In Langendorff-perfused hearts, there were no differences in mean actio

92 xt of well preserved contractile function in perfused hearts, we observed decreased glucose oxidation

93 ial T-wave alternans in isolated Langendorff perfused hearts.

94 orking hearts (LWHs) than Langendorff (LANG) perfused hearts.

95 ventricular contractile function in isolated perfused hearts.

96 n in isolated cardiomyocytes and Langendorff-perfused hearts.

97 from the entire outer surface of Langendorff-perfused hearts.

98 similar to patterns recorded in Langendorff-perfused hearts.

99 isolated cardiac myocytes and in Langendorff-perfused hearts.

100 mitochondria in ventricular cells in intact perfused hearts.

101 by echocardiography, ECG, and in Langendorff-perfused hearts.

102 and ventricular tachycardia inducibility in perfused hearts.

103 Perfusing hearts with SN yielded markedly increased myoc

104 eatment with BAPN increased outflow rates in perfused human and porcine anterior segments, whereas ge

105 r data has been developed and validated with perfused human DB-1 melanoma cells carrying the BRAF V60

106 utinin-I demonstrated an increased number of perfused human vessels in ECFC + MPC compared with ECFC.

107 ied habitats previously associated with well-perfused, hypoxic and/or necrotic tumor compartments.

108 Urea permeability in isolated perfused IMCDs showed basal permeability in the UT-A1(+/

109 Ten surgically resected lobes were perfused in acellular and normothermic condition.

110 Twenty-four human lungs were perfused in cellular EVLP system for 2 h, and tissue sam

111 Using the decerebrated, arterially perfused in situ preparations of juvenile rats, we recor

112 ional analysis of the mouse cauda epididymis perfused in vivo showed that luminal ATP and adenosine m

113 Also, when whole blood was perfused in von Willebrand factor-coated microfluidic ch

114 significantly better preserved in the hearts perfused in WM (median 11-hour cardiac index/1-hour card

115 he adenovirus-injection sites in Langendorff-perfused intact working hearts using confocal Ca(2+) ima

116 eriments disrupting electrical conduction by perfusing intact adult and embryonic hearts with a gap j

117 exogenously-derived mitochondria injected or perfused into ischemic hearts were rapidly internalised

118 iabetic plasma or isolated diabetic MPs were perfused into normal microvessels or systemically transf

119 Additionally, NVP-AAM077 at 0.3 nmol perfused into the contralateral ventricle, considerably

120 nary artery, based on the myocardial mass it perfuses, is well documented, but little is known about

121 For (i), we perfused isolated murine working hearts with [U-(13)C(6)

122 ontaining 145 or 155 mM Na(+) in Langendorff perfused isolated rat heart preparations.

123 For (ii), we perfused isolated working hearts with [U-(13)C(6)]glucos

124 sa NO production was similar in the isolated perfused juxtaglomerular apparatus of wild-type (WT) and

125 ond to tubuloglomerular feedback in isolated perfused juxtaglomerular apparatus preparations, althoug

126 Histologically, HBOC-201 and blood-perfused kidneys had vastly reduced acute tubular necros

127 Studies in kidney slices and isolated perfused kidneys of control and I1-KO mice demonstrated

128 is was also reflected by kinetic analyses in perfused liver, which showed a decreased glutamine synth

129 epatocytes and hepatocytes within the intact perfused liver.

130 The HBOC-perfused livers extracted more oxygen than those perfuse

131 ble knockout (DKO) on pyruvate metabolism in perfused livers from lean and diet-induced obese (DIO) m

132 C-based perfusion fluid and matched to 5 RBC-perfused livers.

133 (which include virtual nonenhanced, iodine, perfused lung blood volume, lung vessel, automated bone

134 d vascular permeability measured in isolated perfused lungs ex vivo increased at 2 wk after 15 Gy of

135 METHODS AND Isolated ventilated and perfused lungs from Cox4i2(-/-) mice lacked acute HPV.

136 The fraction of perfused mature tumor microvessels was increased in Epsi

137 ent, where T cells were dispersed within the perfused media and allowed to infiltrate.

138 with supporting nourishment provided through perfused media channels.

139 se and caspase-cleaved cytokeratin 18 in the perfused medium.

140 term (14-35 days) and phenotypic features of perfused microtumours compared with those in the static

141 re we use an engineered organotypic model of perfused microvessels to show that activation of the tra

142 urvival on nutrient delivery through living, perfused microvessels.

143 Neuronal cell bodies are captured from perfused mouse brain slices by patch clamping, and lipid

144 itin properties were analyzed in Langendorff-perfused mouse hearts after 20-minute ischemia/60-minute

145 uabain-treated and hypertrophied Langendorff-perfused mouse hearts are studied by (23)Na, (31)P, (13)

146 sponse to myostatin in cardiomyocytes and in perfused mouse hearts.

147 tocol to measure glycogen levels in isolated perfused mouse livers using chemical exchange saturation

148 els in a restricted region of isolated blood-perfused mouse lungs.

149 tionally, the distribution of quinidine into perfused mouse myocardium was decreased by almost an ord

150 of early atherosclerosis by fabricating and perfusing multi-layer arteriole-scale human tissue-engin

151 ys-162 by NO2-OA pretreatment in Langendorff-perfused murine hearts prevented the p38-MKK3 disulfide

152 ministrations in highly oxidative and highly perfused muscle, our data suggest that neither mitochond

153 model that generates disorganized and poorly perfused neovascular tufts that mimic human ocular disea

154 m the unique establishment of new functional perfusing networks defined as angiogenesis.

155 ts represented a much larger proportion than perfused nonventilated ones.

156 lecular differences between normothermically perfused (normothermic machine perfusion, NMP) human kid

157 Eleven clinically declined kidneys were perfused normothermically, with 6 being from donors afte

158 ues that exceed 1 cm in thickness and can be perfused on chip for long time periods (>6 wk).

159 vity was weaker in the direction of baseline-perfused or hypoperfused areas.

160 pproach, where only the pulmonary artery was perfused; or a conventional approach with a prostaglandi

161 cAc to monitor mitochondrial redox in cells, perfused organs and in vivo.

162 ant dose (absorbed dose to tissue) in highly perfused organs such as the liver and kidney.

163 Human liver tissue was perfused over a 30 hour period with hourly sampling from

164 When human whole blood was perfused over collagen at arterial shear rates, elevatin

165 25 optical movies from 5 ex vivo Langendorff-perfused PersAF sheep hearts (sensitivity/specificity, 9

166 From 3 Langendorff-perfused pig hearts, 180 intramural unipolar electrogram

167 tems for panoramic imaging using Langendorff-perfused pig hearts, a clinically-relevant model in basi

168 From 13 (31.0%) eyes with a perfused posterior pole (an area encompassing a 5 disc d

169 rminals were significant targets for locally perfused pramipexole, ropinirole, and gabapentin, which

170 Using a novel in situ perfused preparation for studying motor control, we show

171 ation (SNS) in fully innervated, Langendorff-perfused rabbit and mouse hearts.

172 bstantiated using the lower-cost Langendorff-perfused rabbit heart model.

173 n VF was induced electrically in Langendorff-perfused rabbit hearts (n=22) and terminated with a defi

174 ride (LPS), on HCO(3) absorption in isolated perfused rabbit OMCDi.

175 Using a Langendorff perfused rat heart, we show that the acetylcholine analo

176 VFT was determined in Langendorff perfused rat hearts by burst pacing until sustained VF w

177 dies were performed on isolated, Langendorff-perfused rat hearts to assess cardiac electrophysiology

178 Using isolated perfused rat hearts, acidosis was induced using an ammon

179 nd (99m)Tc-sestamibi were tested in isolated perfused rat hearts.

180 double that of (99m)Tc-sestamibi in isolated perfused rat hearts.

181 urnover ( approximately citric acid flux) in perfused rat hearts.

182 est this hypothesis, we employed an isolated perfused rat kidney model.

183 In perfused rat liver, hepatocyte shrinkage induces a Fyn-d

184 uts to control hepatic glucose production in perfused rat liver.

185 ts major metabolite norclozapine in isolated perfused rat liver.

186 Single perfused rat mesenteric microvessels were perfused with

187 ose-stimulated GLP-1 secretion from isolated perfused rat small intestine.

188 compared to triceps surae muscles of 'freely perfused' rats.

189 show that the human endothelial cells in the perfused rBELs colonize the liver sinusoids and express

190 Furthermore, lactate entry into the better-perfused recipient cells has a favourable alkalinizing e

191 ted by reduction of the microvesicles in the perfused samples.

192 e found that warm branches had less sugar in perfused sap than cold branches due to increasing parenc

193 observed in young pigs; however, Langendorff-perfused SCN5A(E558X/+) hearts had an increased propensi

194 the renal pelvis, identifying well and poor perfused segments.

195 Isolated, Langendorff-perfused sheep hearts were optically mapped.

196 ltage-calcium optical mapping of Langendorff-perfused SHR hearts revealed that H2 O2 -induced VT/VF a

197 itro (Franz cell chamber), ex vivo (isolated perfused skin models), and in vivo (vasoconstrictor assa

198 The proportions of perfused small vessels were (mean +/- scanning electron

199 However, perfused small-vessel density, small-vessel density, and

200 optical mapping was performed in Langendorff-perfused Sprague-Dawley rat hearts (n=18), where novel a

201 ntained an islet chamber with the ability to perfuse stimulants and an amino acid measurement system

202 (6 females, age: 24 +/- 2 y) donned a water-perfused suit circulating 34 degrees C water and complet

203 passive heat stress (HS; 49 degrees C water-perfused suit) to match the exercise-induced increases i

204 es C rise in oral temperature (T(or) ; water perfused suit) was induced in 13 healthy normocholestero

205 re measured during whole-body cooling (water-perfused suit).

206 kin temperature (Tsk ) 30.5 degrees C; water-perfused suit).

207 Isolated perfused swine hearts were stained with di-4-ANEPPS and

208 ancement ratio between stenotic and normally perfused territories was determined for each stenosis.

209 rom pressure injury, and a recoil that helps perfuse the coronary arteries.

210 al and bronchial) and pulmonary circulations perfuse the lung.

211 owards essential circulations, such as those perfusing the brain.

212 (+) concentration in patch pipette solutions perfusing the intracellular compartment was high and eli

213 that stimulation of hepatic nerve fibres or perfusing the liver with physiological concentrations of

214 Upon perfusing the vascular lumen with whole blood, the micro

215 gs to eliminate pulmonary sensory inputs and perfusing them with hyperoxic artificial cerebral spinal

216 ed to patches of tissue factor and 2) plasma perfused through a capillary coated with tissue factor.

217 nt antagonist for NR2A-containing receptors, perfused through microdialysis probes, markedly reduced

218 predict the distribution of an inulin tracer perfused through the multi-organ human-body-on-chips.

219 roximal tubule epithelial cells and actively perfused through the open lumen.

220 press initiated 30 s of -20 degrees C fluid perfusing through a custom-made device secured against t

221 eful in this pursuit, it must be able to (1) perfuse tissue and collect the perfusate for quantitativ

222 represents its partition coefficient in well-perfused tissue), and injection of (111)In-labeled white

223 To model blood flow through perfused tissue, we follow the approach of others and tr

224 sis and ingrowth of recipient vasculature to perfuse tissues, preventing analysis of biological proce

225 ntributions of non-glucose nutrients in well-perfused tumor areas.

226 agents improve drug penetration in a poorly perfused tumor.

227 rstitial fluid, the extracellular fluid that perfuses tumors.

228 venting mechanisms become important in under-perfused tumours.

229 In kidneys perfused under constant flow or constant pressure, compa

230 In parallel, human anterior segments were perfused under controlled flow.

231 In this technique, the cells are perfused under defined shear stresses over a monolayer o

232 ter arterial cannulation, the specimens were perfused using a combined detergent/polar solvent decell

233 human donor lungs were randomly divided and perfused using either low-flow acellular or high-flow ce

234 Three kidneys were perfused using Ringer's lactate to replace excreted urin

235 ce excreted urine volume, and 8 kidneys were perfused using urine recirculation to maintain perfusate

236 anoids transplanted into mice form a stable, perfused vascular tree, including arteries, arterioles a

237 , and quantifiably facilitate development of perfused vasculature in a microfluidic system.

238 al epithelial cells (HIECs), and incorporate perfused vasculature into a gut-on-a-chip (GOC) model th

239 ore demonstrate the feasibility of including perfused vasculature, including ISEMFs, as critical comp

240 us remodeling through selective expansion of perfused vasculature.

241 s typically experience lesions only in lowly perfused venous capillaries of the cerebrovasculature is

242 , 2014, and Oct 23, 2016, 93 lung pairs were perfused, ventilated, and assessed on the OCS Lung.

243 density, proportion of perfused vessels and perfused vessel density.

244 significant improvement in the proportion of perfused vessels (control: 57.2 +/- 14% to 66 +/- 14.8%;

245 2.7 [2.6-2.9]; p < 0.003), the proportion of perfused vessels (from 79% [57-88%] to 92% [88-97%]; p <

246 The proportion of perfused vessels (PPV) and the mean flow index (MFI) wer

247 rease of total vessel density, proportion of perfused vessels and perfused vessel density.

248 ExECs were capable of forming functionally perfused vessels at the host/graft interface and increas

249 .001; group and time interaction: p = 0.85); perfused vessels density (control: 15.6 +/- 4 mm/mm to 1

250 l density, small-vessel density, and percent perfused vessels were consistently higher and then stabi

251 The perfused volume of lung was decreased by about 25% at 1,

252 Perfused volume was determined by comparing the volume o

253 time delay and the method of fixation (i.e., perfused vs. nonperfused brains) may influence the resul

254 cardiomyocytes and in an ex vivo Langendorff-perfused whole-heart model.

255 d stage of hypertrophy, isolated hearts were perfused with (13)C LCFA during dynamic-mode (13)C nucle

256 A subset of hearts was perfused with 1 mum tolbutamide (TOLB) to identify the l

257 1 mug/mL lipopolysaccharide for 6 hours and perfused with 100 mumol/L CORM-401 (or inactive compound

258 Cells attached to microcarrier beads were perfused with 26 mm [1,6-(13)C2]glucose under normoxic c

259 When murine islets were perfused with 3 mM glucose, the secretion rates of 9 ami

260 chemia, 3.5 hours of cold ischemia, and then perfused with a humanized anti-CD47 monoclonal antibody

261 ed human spinal column samples, unilaterally perfused with an iodinated vascular contrast agent, and

262 An in vitro bovine liver model perfused with autologous blood via the portal vein at th

263 A sample from rat liver perfused with clozapine was distributed to three sites f

264 nnel lined by human vascular endothelium and perfused with culture medium, and a porous membrane sepa

265 On the microfluidic chip, droplets were perfused with different transport-competent or -incompet

266 ngendorff rabbit hearts stained with ICG and perfused with electromechanical uncouplers.

267 provided by EVNP, the second kidney was not perfused with EVNP and was directly implanted to a 64-ye

268 le perfused rat mesenteric microvessels were perfused with fluorescent endothelial cell membrane and

269 hese thick vascularized tissues are actively perfused with growth factors to differentiate hMSCs towa

270 Five discarded high-risk human livers were perfused with HBOC-based perfusion fluid and matched to

271 unctional and electrical responses of hearts perfused with histones.

272 Three livers were perfused with hypothermic machine perfusion, 1 full live

273 er two intradermal microdialysis probes, one perfused with ISO saline and the other with HYPER saline

274 eart in vitro (six groups, each n = 6/group) perfused with Krebs-Henseleit buffer alone or with propo

275 -Dawley rats were mounted onto an organ bath perfused with Krebs-Henseleit buffer.

276 e cornu Ammonis 1 region of slices that were perfused with L-655,708 (100 nM).

277 Protocol 1 (n = 8), microdialysis sites were perfused with lactated Ringer solution (Control), 40 pm,

278 0 nm ET-1; in Protocol 2 (n = 11) sites were perfused with lactated Ringer solution (Control), 400 nm

279 Kidneys were isolated and perfused with modified Krebs-Henseleit buffer.

280 microvessels derived from human fibroblasts perfused with mouse and human erythrocytes.

281 (control), whereas its paired kidney was EMS perfused with MSC (1 x 10).

282 of extracellular matrix and are continuously perfused with nutrients via a bioreactor system.

283 l experiments, kidneys were normothermically perfused with oxygenated blood for 1 hour after cold sto

284 om an ischemia/reperfusion Langendorff model perfused with oxygenated blood from an arrested animal b

285 In the HESP group, limbs were continuously perfused with oxygenated histidine-tryptophan-ketoglutar

286 MP-extremities were perfused with oxygenated Steen solution at a constant pr

287 When perfused with Palm, T2DM hearts exhibited improved contr

288 In the treated groups, hearts were perfused with ranolazine or GS-967 at 2 minutes of VF.

289 used livers extracted more oxygen than those perfused with RBCs (O2 extraction ratio 13.75 vs 9.43 %

290 The first kidney was perfused with red cell-based perfusate at 37 degrees C f

291 Test kidneys were perfused with TLN treated solution (n=19).

292 Test kidneys were perfused with TLN-treated solution (n = 19).

293 D and LVDP were significantly higher in LWHs perfused with TOLB (199 +/- 16 ms; 92 +/- 5.3 mmHg) than

294 Each muscle fibre was perfused with Tyrode solution pre-equilibrated with eith

295 h (DCD) canine hearts can be resuscitated if perfused with warm blood.

296 rately predicts drug permeability and can be perfused with whole blood.

297 Small intestines were perfused with, and stored in, preservation solution (Cus

298 Isolated rat hearts were perfused within a gamma-detection apparatus to character

299 covery of the hearts was assessed on a blood-perfused working heart rig.

300 rectly into the KF of the in situ arterially perfused working heart-brainstem preparation of rat resu