ライフサイエンスコーパス: perilesional

1 on were considered positive because of clear perilesional (18)F-FDG uptake at the delayed acquisition

2 nization in four out of five cases, but with perilesional activation within the damaged left hemisphe

3 ool to assess diffuse brain inflammation and perilesional activity in progressive multiple sclerosis

4 overy of function by normalizing exaggerated perilesional alpha5-GABAAR-dependent tonic inhibition.

5 nds to relatively healthy-appearing adjacent perilesional and distant nonlesional skin has not been s

6 n healthy human hair follicles as well as in perilesional and intralesional skin of acne vulgaris les

7 The roles of perilesional and ipsilesional tissue in recovery from po

8 d separately from healthy control skin, with perilesional and lesion skin clustering together and awa

9 D6 expression consistently dropped in perilesional and lesional skin, coincident with developm

10 perplasia with keratin 16 positivity in both perilesional and lesional skin, with comparable levels o

11 a marked upregulation of IL-17 signaling in perilesional and lesional skin.

12 ndifferentiated" (similar DVR across lesion, perilesional and NAWM volumes).

13 While perilesional and tumoral follow-up [(18)F]FDG-uptake beh

14 llow-up [(18)F]FDG-uptake behaved uniformly, perilesional and tumoral reaction may differ in follow-u

15 ression was evaluated in blood and lesional, perilesional, and nonlesional skin biopsies.

16 We sought to characterize lesional, perilesional, and nonlesional skin in patients with HS.

17 to measure relative binding in the lesional, perilesional, and surrounding normal-appearing white mat

18 iopsy locations were defined as "lesional," "perilesional," and "nonaffected" conjunctiva.

19 (FA) was extracted from each lesion core and perilesional area.

20 Differences in FA values across core and perilesional areas by SEL category were assessed using t

21 s exhibited FA decline over time in core and perilesional areas compared with other lesions.

22 T2wi can help to distinguish the lesions and perilesional areas even in a clinical MRI-negative case.

23 a survivors, we devised a method to localize perilesional areas exhibiting peak MSE abnormalities, an

24 increased significantly from the NAWM to the perilesional areas, T2 hyperintense lesions, and T1 hypo

25 Thbs4, from the dorsal and medial SVZ to the perilesional barrier surrounding the ischemic core, know

26 Perilesional biopsies gave higher positive DIF than lesi

27 itive in 14% of lesional biopsies, in 86% of perilesional biopsies, and in 17% of those from nonaffec

28 t, direct immunofluorescence microscopy of a perilesional biopsy specimen or serological tests are ne

29 by direct immunofluorescence microscopy of a perilesional biopsy, with serum anti-Dsg1 or anti-Dsg3 a

30 um contrast agent deposition most evident at perilesional boundaries.

31 Transient perilesional brain oedema is seen around the calcified f

32 Particularly, perilesional brain tissues may attract abnormal Mn accum

33 as found between the sensitivity of DIF on a perilesional buccal biopsy and a normal buccal biopsy (8

34 When evaluated in perilesional capillaries surrounding ductal carcinoma in

35 reclinical models and has been used to treat perilesional cerebral edema and radiation necrosis.

36 tumor border that contained minimal to mild perilesional changes.

37 t, alone or in combination with tPA, limited perilesional complement deposition, reduced microgliosis

38 B4Crry treatment limited perilesional complement deposition, reduced microgliosis

39 covery may occur by engaging residual (e.g., perilesional) components.

40 Perilesional conjunctival biopsies are associated with a

41 These results support the need to sample perilesional conjunctival tissue in patients with suspec

42 Although the stroke perilesional cortex (PLC) has been hypothesized as a pot

43 oke interacted with task-related activity in perilesional cortex and affected grasping.

44 ein levels in proximal and distal regions of perilesional cortex and in homotopic areas of young adul

45 These temporal patterns of expression in the perilesional cortex and ipsilateral dorsal striatum were

46 tended to the cortical lesion, including the perilesional cortex around the lesion core.

47 nimals within proximal and distal regions of perilesional cortex compared with distal neocortical are

48 Three of these subjects had responses in perilesional cortex in response to blind field stimulati

49 left occipital and ventral occipitotemporal perilesional cortex, and increased feedback connectivity

50 cell death, and microglial activation in the perilesional cortex, lesion core zone, and choroid plexu

51 creased overall Iba1 immunoreactivity in the perilesional cortex, suggesting that TnC might restrict

52 umor necrosis factor-alpha expression in the perilesional cortex.

53 effect is likely to be mediated by increased perilesional cortical excitability via chronic activatio

54 recovery after ischemia via augmentation of perilesional cortical excitability.

55 luorescent dye (CMFDA) were engrafted in the perilesional deep cortex, and animals were sacrificed at

56 al cells in well-formed blood vessels in the perilesional dermis.

57 ghest in the lesion), "peripherally active" (perilesional DVR highest), "inactive" (DVR highest in su

58 The transient development of perilesional edema (PE) around >/=1 calcification (defin

59 nd 30-65% of these cases are associated with perilesional edema (PE), likely due to host inflammation

60 iameter; four of these developed symptomatic perilesional edema at 3 (n = 2) or 8 (n = 2) months afte

61 s had hemorrhaged, and two had symptoms from perilesional edema requiring radiosurgery, but all three

62 Intense perilesional enhancement of metastases on early gadolini

63 thickness of hepatic parenchyma with intense perilesional enhancement on early gadolinium-enhanced im

64 thickness of hepatic parenchyma with intense perilesional enhancement was calculated.

65 In the remaining three patients, no perilesional enhancement was observed, and at histopatho

66 In one patient, mild perilesional enhancement was shown.

67 gadolinium-enhanced images showed prominent perilesional enhancement, which correlated with a thick

68 meglumine were retrospectively evaluated for perilesional enhancement.

69 PV-like suprabasal acantholysis and stained perilesional epidermis in a fishnet-like pattern, indica

70 k of expression is localized to hyperplastic perilesional epidermis.

71 e blisters in neonatal mice and weakly bound perilesional epidermis.

72 ensin-2 immunoreactivity in the lesional and perilesional epithelium - in particular in pustules - an

73 spheric areas surrounding the stroke lesion (perilesional) exhibit pathological oscillatory slowing a

74 , profibrotic macrophages and microglia, and perilesional glia.

75 vely evaluated in the lesion and in adjacent perilesional gray and white matter.

76 up, along with a significant increase in the perilesional halo (p < 0.05); however, no significant ch

77 1), chest tube (coefficient, 0.18; P = .26), perilesional hemorrhage (coefficient, -0.03; P = .63), o

78 ith a chest tube placed in 32 of 827 (3.9%), perilesional hemorrhage in 353 of 827 (42.7%), and hemop

79 tions of pneumothorax, chest tube placement, perilesional hemorrhage, and hemoptysis were recorded.

80 Perilesional HS skin has a transcriptomic and molecular

81 ge systems in tissue around the lesion (the 'perilesional' hypothesis), or by homotopic cortex in the

82 opsies were lesional in 22% of cases (7/32), perilesional in 22% (7/32), and from nonaffected conjunc

83 terns (ring, heterogeneous, homogenous), and perilesional increased vascularity were studied.

84 actors were changed simultaneously: depth of perilesional injection and dose.

85 tients (group 2) after changing the depth of perilesional injections and dose.

86 Both groups had perilesional injections of (99m)Tc-sulfur colloid follow

87 Group 2 had perilesional injections on top of, beside, and just belo

88 n HS lesions compared to skin of healthy and perilesional intertriginous areas.

89 the end, animals were randomly selected for perilesional intracortical microstimulation mapping and

90 ted physiological and morphologic changes in perilesional layer 3 pyramidal neurons.

91 -scale MSE (slow activity), and increases in perilesional low-gamma (25-50 Hz) and fine-scale MSE (fa

92 Extensive migration of perilesional microglia was apparent by 24 h after injury

93 present a detailed analysis of long-distance perilesional microglial migration using time-lapse confo

94 reduced migration velocity and the number of perilesional migratory microglia without affecting direc

95 rtex, likely through enhancing plasticity in perilesional motor and premotor cortices.

96 Human anti-hDsg3 antibodies are detected in perilesional mucosa as well as in sera of recipient mice

97 ted in lesions, with gradual tapering toward perilesional NAWM.

98 effect of mild passive focal cooling of the perilesional neocortex on the development of neocortical

99 percussion injury in rats reliably induces a perilesional, neocortical epileptic focus within weeks a

100 these striking abnormalities, neurons in the perilesional network could be modulated volitionally to

101 We initially found that the perilesional network demonstrated abnormally increased s

102 Hence, perilesional nonexudative choroidal neovascular tissue (

103 ith absence of swelling and low frequency of perilesional oedema (10%) at diagnosis, as compared with

104 ral necrosis (77.8%), and moderate to marked perilesional oedema (55.55%).

105 Perilesional oedema is common and associated with episod

106 The same values were higher in perilesional oedema of glioblastoma (mean pre-contrast R

107 were calculated from lesion core, wall, and perilesional oedema using free-hand region of interest a

108 In a nested case-control substudy, perilesional oedema was assessed by MRI at the time of s

109 n MRI evaluation within 5 days of the event; perilesional oedema was seen in 12 patients (50%) compar

110 ime quantitative PCR comparing lesional with perilesional or healthy skin.

111 A biopsy can be taken from either perilesional or normal buccal mucosa.

112 rtical infarct (RSSI), some patients develop perilesional or remote hyperintensities ('caps/tracks')

113 R111 binding in MS lesions (P < 0.05) and in perilesional (P < 0.05) and nonlesional white matter wit

114 f all points, all responding points, and all perilesional points all decreased significantly with tim

115 ts with Broca's aphasia, preservation of the perilesional posterior inferior temporal cortex was asso

116 l structural fibres along these pathways and perilesional primary visual cortex activity.

117 effect characterized by an intralesional or perilesional reaction.

118 tive stimulation is shown, marked by greater perilesional reorganization in stimulation- treated anim

119 es including abnormal patterns of FAF in the perilesional retina.

120 the proton density/T2 scan, and a two-voxel perilesional ring, from the SPM8 derived white matter ma

121 Contralesional excitation suppressed perilesional S1FP remapping and was associated with abno

122 2-year interval, the microperimetry-derived perilesional sensitivity (eta(2) of 0.73 [0.53, 0.83]; -

123 d cytoskeleton (Arc) protein expression, and perilesional sensorimotor connectivity.

124 icantly increased IL-33 and Tregs marked the perilesional skin and colon in patients with cancer-pron

125 ratosis and basal cell carcinoma lesions and perilesional skin and compared this with region-matched

126 igands for NKG2D are upregulated in vitiligo perilesional skin and especially in patients with active

127 ell carcinomas, actinic keratosis, and their perilesional skin demonstrate a significantly lower caro

128 nation of a biopsy sample from the patient's perilesional skin demonstrated linear deposition of IgG

129 ion in skin biopsies, with healthy-appearing perilesional skin demonstrating a significant correlatio

130 ) polymerase also occurred in both tumor and perilesional skin following treatment.

131 [OA]) and skin biopsy samples (lesional and perilesional skin from 25 PsA patients) were obtained.

132 ultiplex ELISA, we show that active vitiligo perilesional skin is characterized by prominent type 1 a

133 une environment was detected in SCCs and the perilesional skin of cancer-prone DLE patients.

134 IgE-coated mast cells were detected in perilesional skin of the BP patients.

135 rsue a nonocular biopsy of normal-appearing, perilesional skin or oral mucosa when possible.

136 sults of immunohistochemical analysis of the perilesional skin remained positive for CD19 and CD138 i

137 TRKB and TRKC in tumours when compared with perilesional skin.

138 Perilesional sleep-like off-periods can disrupt network

139 These perilesional sleep-like responses were associated with a

140 delivery rate in lesion cores (4.6-fold) and perilesional spaces (6.7-fold).

141 delivery increases to the intralesional and perilesional spaces, respectively.

142 the expression of NI markers in the chronic perilesional spinal cord, and consistently improved neur

143 nhanced interhemispheric inhibition over the perilesional tissue after focal cortical stroke in mouse

144 In stimulated mice, perilesional tissue exhibited transcriptional changes in

145 accumulate with cerebral microvessels in the perilesional tissue further stimulate brain plasticity a

146 influences functional neurological recovery, perilesional tissue remodelling and axonal sprouting of

147 after surgery, the rats were euthanized and perilesional tissue surrounding the mandibular defect wa

148 Perilesional tissue was abnormal in eight patients, with

149 The perilesional tissue was histologically analyzed using he

150 Despite successful remodelling of the perilesional tissue, erythropoietin enhanced axonal spro

151 ithin cortically blind subjects, activity in perilesional tissue, V3A and hMT+ was associated with a

152 he axial area studied contained lesional and perilesional tissue.

153 inhibition and 'plasticity brakes' over the perilesional tissue.

154 ectrin cleavage, and increased cell death in perilesional tissue.

155 ain injury, Mn preferentially accumulated in perilesional tissues expressing gliosis or oxidative str

156 xamine cell-type specific contributions, and perilesional tissues from 41 TBI patients were analyzed

157 transport at the primary injury site and the perilesional tissues secondarily over 6 weeks.

158 f cellular alterations that exist within the perilesional tissues; however, few pharmacological thera

159 Increased perilesional TSPO uptake was present in 57% of the chron

160 e parasite may stay viable even if (18)F-FDG perilesional uptake has disappeared.

161 hese findings uncover fundamental changes in perilesional V1 cortex underlying training-induced resto

162 nlargement of population receptive fields in perilesional V1, which increases blind-field coverage an

163 enhancement, prominent increase in CNR, and perilesional vascularity increase are important findings

164 nt, a slight increase in CNR, and absence of perilesional vascularity increase support findings of be

165 By increasing CNR and providing increased perilesional vascularity, Gadovist can help in the deter

166 toration of excitatory-inhibitory balance in perilesional ventral premotor cortex.

167 infiltration by CD11c+ cells was abundant in perilesional vitiligo skin.

168 g was higher in the white matter lesions and perilesional volumes of MS patients than in white matter

169 the white matter in MS patients as lesions, perilesional volumes, nonlesional white matter with redu

170 rt a hypothesis that microglial apoptosis in perilesional white matter represents an early stage in l

171 ly, we found a zone lacking microglia within perilesional white matter, immediately beyond the active

172 human MS, microglial priming was evident in perilesional white matter, in close proximity to C3b/iC3

173 od-brain barrier permeability changes in the perilesional white matter, which predicts lesion progres

174 t enhancement into the formerly hypoperfused perilesional zone.