ライフサイエンスコーパス: perinatal

1 e, but it does represent a potential site of perinatal acquisition of S. agalactiae, a major cause of

2 rovider-initiated deliveries, and to prevent perinatal adverse outcomes.

3 this approach reduced subsequent maternal or perinatal adverse outcomes.

4 nd after adjustment for sociodemographic and perinatal adversities and IQ, psychotic experiences at a

5 follicle assembly in the mouse occurs during perinatal ages and largely determines the ovarian reserv

6 DA) neurons of the VTA in rat pups following perinatal alcohol and joint nicotine-alcohol exposure.

7 ce during the infancy in rats in response to perinatal alcohol/ or nicotine-alcohol exposure.

8 ing differences in Lck transcription between perinatal and adult gammadelta T cell development.

9 In contrast, in perinatal and adult male and female Zfpm1 mutants, a lat

10 in the skin innate immune system between the perinatal and adult periods of life.

11 stakeholders to inform strategies to reduce perinatal and childhood mortality in sub-Saharan Africa

12 bit sustained GI colonization following both perinatal and postnatal exposure to GBS, with 21% and 27

13 Using murine models of both perinatal and postnatal GBS acquisition, we assessed the

14 Both perinatal and postnatal murine models of GBS acquisition

15 National registries provided information on perinatal and sociodemographic characteristics, on psych

16 In line with this, we identified an altered perinatal and/or postnatal expression of genes involved

17 al, and behavioral consequences of prenatal, perinatal, and adolescent exposure to cannabis/delta-9-t

18 We linked laboratory, perinatal, and hospital data of 469 589 children born in

19 nal DALYs arose from communicable, maternal, perinatal, and nutritional disorders.

20 tal exposure to testosterone proprionate, 3) perinatal androgen exposure guides bone marrow MC progen

21 n postnatal day 4, shortly after a transient perinatal androgen surge in males that could play an org

22 s is linked with the naturally high level of perinatal androgens and can be recapitulated in females

23 Thus, factors affecting levels of perinatal androgens could have a significant impact on M

24 se severity are established in early life by perinatal androgens.

25 In conclusion, perinatal antibiotics markedly disturbed vertical transm

26 the intestinal microbiome but the effects of perinatal antibiotics on gut microbiome in vaginally del

27 The impact of perinatal antibiotics on vertical transmission of microb

28 ) and a treatment group (10 pairs) receiving perinatal antibiotics.

29 The perinatal asphyxia (PA) group showed a significant decre

30 the present work is to analyze the effect of perinatal asphyxia on different subpopulations of GABAer

31 common underlying causes of stillbirth were perinatal asphyxia or hypoxia (130 [72%] of 180 stillbir

32 ications (187 [42%] of 449 neonatal deaths), perinatal asphyxia or hypoxia (98 [22%]), and neonatal s

33 immersion in water (19 min) at 37 degrees C (perinatal asphyxia).

34 exposed to 10 degrees C during 30 min after perinatal asphyxia.

35 Perinatal brain abnormality was associated with less inc

36 ors in offspring, but how it interplays with perinatal brain injury (especially birth asphyxia or hyp

37 /A >= 1.0 mol:mol were equally predictive of perinatal brain injury (sensitivity 100%, specificity 93

38 e and survival time of newborns, and reduces perinatal brain injury in cases of intrauterine inflamma

39 5%] of 222; excepting cases with evidence of perinatal brain injury) than in those with combined (19

40 , myelination, and functional recovery after perinatal brain injury.

41 epigenetic misregulation in animal models of perinatal cannabinoid exposure (using synthetic cannabin

42 These results reveal how perinatal cannabinoid exposure retards an early mileston

43 The prevalence of detrimental outcomes of perinatal cannabis exposure is likely to increase in tan

44 e maturation of oxidative phosphorylation in perinatal cardiomyocytes.

45 38.3%) and +28.9% (from 13.9% to 17.9%) for perinatal care (p-value = 0.13).

46 Advances in perinatal care have improved survival for premature babi

47 or extremely preterm infants with suboptimal perinatal care or major antenatal events that cause seve

48 World Health Organization (WHO)-recommended perinatal care outputs assessed in the intervention grou

49 of prematurity are to optimize prenatal and perinatal care, improve diagnostic acumen worldwide and

50 in pregnancy was ascertained through routine perinatal care.

51 iated with an increase in infant deaths from perinatal causes (1.214 [1.156, 1.275; p < 0.001]) and f

52 had more chronic diseases, experienced more perinatal complications, and utilized more acute care po

53 during pregnancy causes severe maternal and perinatal complications, despite a lack of vertical tran

54 The first mode revealed traces of perinatal complications, including preterm and twin birt

55 persons has moderate net benefit in reducing perinatal complications.

56 orn after an uncomplicated pregnancy with no perinatal complications.

57 verse events were pregnancy, puerperium, and perinatal conditions (in 255 [10%] of 2530 women in the

58 Adverse in-utero and perinatal conditions might contribute to an increased su

59 onstrated the importance of the link between perinatal cytokines and abnormal behaviors in offspring,

60 Using data from the National Perinatal Data Collection we compared rates of preterm b

61 The risk of perinatal death and severe neonatal morbidity increases

62 rsisted throughout development, resulting in perinatal death of 35% of Olfml3-deficient mice.

63 erience adverse perinatal outcomes including perinatal death, admission to a neonatal unit, resuscita

64 s were also strongly associated with TdP and perinatal death.

65 nduced by cPAF, preventing preterm birth and perinatal death.

66 ssociated with a severe rhythm phenotype and perinatal death: 9 (82%) showed signature LQTS rhythms,

67 Maternal deaths and perinatal deaths following caesarean sections are dispro

68 Perinatal deaths occurred in one (<0.1%) versus eight (0

69 n of Diseases, Tenth Revision application to perinatal deaths.

70 Prenatal or perinatal deletion of Arc/Arg3.1 alters cortical network

71 1.16], p-value 0.81) nor in other important perinatal, delivery, and maternal outcomes.

72 sociated with a lower likelihood of onset of perinatal depression (pooled risk ratio [RR], 0.61 [95%

73 ts and harms of preventive interventions for perinatal depression in pregnant or postpartum women or

74 sual care (EUC; so-called because, in India, perinatal depression is not typically treated) only (con

75 ses clinical evidence showing the effects of perinatal depression on offspring physical and behaviour

76 tpartum persons who are at increased risk of perinatal depression to counseling interventions.

77 tween physical activity during pregnancy and perinatal depression, and it is limited for different ph

78 Perinatal depression, which is the occurrence of a depre

79 ntervention recommended for the treatment of perinatal depression.

80 We enrolled 280 (84.1%) women with perinatal depression; 140 women were assigned to the THP

81 in widespread expansion of oncogenes during perinatal development but not in adults.

82 in TH expression levels, specifically during perinatal development compared to mice raised under Long

83 d masculinization of the rat amygdala during perinatal development produces higher levels of juvenile

84 These data identify a perinatal developmental period, in which neuronal GALC e

85 Some children with CVI and a history of perinatal distress have prenatal dysgenesis of the devel

86 Thus, perinatal dysphagia may be an early indicator of disrupt

87 g, feeding, and swallowing from birth onward-perinatal dysphagia-is often associated with several neu

88 ions varies considerably with factors in the perinatal environment and the genetic background of the

89 The maternal perinatal environment modulates brain formation, and alt

90 Neonatal APPs varied with perinatal environmental factors and maternal/fetal pheno

91 dren with severe CVI and clinical history of perinatal events were included.

92 s the cellular and molecular consequences of perinatal exposure (mostly in rodents) to representative

93 loping infant oral microbiome, the effect of perinatal exposure (without infection) appears transient

94 of PBDEs, on glucoregulatory parameters in a perinatal exposure model using female C57Bl/6 mice.

95 However, perinatal exposure to adverse environments can also be a

96 Perinatal exposure to H pylori extract or its immunomodu

97 offspring in a sex-specific manner following perinatal exposure to nicotine in only the F0 gestation,

98 ogens and can be recapitulated in females by perinatal exposure to testosterone proprionate, 3) perin

99 st study to evaluate the association between perinatal exposure to UFPs and the incidence of childhoo

100 ltered following alcohol or nicotine-alcohol perinatal exposure when compared to saline control.

101 shed rat model for both nicotine and alcohol perinatal exposure, we investigated miRNA and mRNA expre

102 Associations between perinatal factors (gestation, labour, sex, birth size),

103 tigated the association between in-utero and perinatal factors and suicide, suicide attempt, and suic

104 ngitudinal studies that account for relevant perinatal factors are required.

105 fter preterm birth in combination with other perinatal factors is a strong risk factor for LRD, sugge

106 and of how this development is influenced by perinatal factors.

107 hrough maternal immunization, a reduction in perinatal GBS disease might be possible.

108 Here, we report that perinatal glucocorticoid exposure had long-term conseque

109 We found that perinatal glucocorticoid exposure resulted in persistent

110 Unique to the natural history of perinatal HCMV infections is the occurrence of congenita

111 bortion but other important reproductive and perinatal health outcomes.

112 terventions with public health education and perinatal healthcare service improvement could have impl

113 varying disparities in access and quality of perinatal healthcare.

114 Perinatal hepatic inflammation can have devastating cons

115 ssical monocytes determine susceptibility to perinatal hepatic inflammation in late gestation fetuses

116 In this mathematical modelling study of perinatal hepatitis B transmission and disease progressi

117 Most U.S. children with perinatal hepatitis C virus (HCV) exposure fail to recei

118 Disruption of Ezh1 and Ezh2 in livers caused perinatal hepatocytes to differentiate prematurely and t

119 tal characteristics, quality of family life, perinatal history, cardiometabolic health, cognition, an

120 The main outcome measures were perinatal history, visual and neurologic findings, and m

121 We observed age-stratified associations of perinatal HIV exposure on community composition, with HE

122 acterial communities, however, the impact of perinatal HIV exposure on the oral microbiota remains un

123 ions in mothers and infants, irrespective of perinatal HIV exposure or infant CMV status at 6 months

124 and middle-income countries where the higher perinatal HIV exposure rates result in cotrimoxazole pro

125 rospective study of young adults living with perinatal HIV from 14 sites in the USA.

126 pression during pregnancy, women living with perinatal HIV infection have a high risk of post-partum

127 a on pregnancy history for women living with perinatal HIV infection in the Pediatric HIV/AIDS Cohort

128 The incidence of perinatal HIV infection in the United States peaked in 1

129 Perinatal HIV infection was significantly associated wit

130 end the window of opportunity for preventing perinatal HIV infection when treatment is delayed.

131 artum outcomes among young women living with perinatal HIV infection who are now ageing into adulthoo

132 2017, we enrolled 323 women, of whom 234 had perinatal HIV infection, and reported age at sexual debu

133 Perinatal HIV transmission has substantially decreased w

134 ly a preferred regimen for the prevention of perinatal HIV transmission with raltegravir recommended

135 and middle-income countries where the higher perinatal HIV-exposure rates result in cotrimoxazole pro

136 The remaining 3 trials provided a perinatal home-visiting intervention to pregnant Native

137 in type I interferon signaling that promotes perinatal HPC expansion and sensitizes progenitors to th

138 Children and adolescents with perinatal human immunodeficiency virus (HIV) infection a

139 e neurodevelopmental effects of maternal and perinatal hypothyroxinemia and that we need to develop m

140 Therefore, a clinical history of perinatal hypoxia-ischemia is nonspecific and merits neu

141 Although perinatal ILC2s were variably replaced across tissues wi

142 tational age infant (SGA), birth defect, and perinatal infant death.

143 eficiency virus (SHIV) in a macaque model of perinatal infection.

144 NA targeting of EMT may prevent pPROM due to perinatal infection.

145 Perinatal infections are a major driver of this burden b

146 ic cases were aged <18 years; congenital and perinatal infections were excluded.

147 included prematurity, respiratory disorders, perinatal infections, and retinopathy of prematurity (RO

148 irthweight infants and those identified with perinatal infections, candidemia, bacteremia, respirator

149 sed on multivariate logistic regression were perinatal infections, candidemia, bacteremia, very low b

150 re clinics at the Instituto Nacional Materno Perinatal (INMP) in Lima, Peru.

151 matrix protein cyclophilin D (CypD) prevents perinatal KET-induced increases in ROS and the resulting

152 important implications as they suggest that perinatal Klotho deficiency contributes to BPD-PH risk a

153 ant genes PROC, PROS1 and SERPINC1 result in perinatal lethal thrombosis in homozygotes and markedly

154 ause of p53 activation, p53(KQ/KQ) mice were perinatal lethal, yet this lethality was averted in p53(

155 esults in placenta and heart over-growth and perinatal lethality (>90%) due to raised extra-cellular

156 Genetic ablation of Ripk1 results in perinatal lethality arising from both RIPK3-mediated nec

157 in mice during fetal development resulted in perinatal lethality associated with structural and genom

158 ient to rescue Ripk1 (mRHIM/mRHIM) mice from perinatal lethality caused by ZBP1-driven cell death and

159 scular specific knockout of Lztr1 results in perinatal lethality due to cardiovascular dysfunction.

160 tion and survival remains unclear because of perinatal lethality exhibited by knockout mice lacking a

161 of endogenous ligands induces ZBP1-mediated perinatal lethality in mice expressing RIPK1 with mutate

162 nza A virus-induced PANoptosis and underlies perinatal lethality in mice in which the RIP homotypic i

163 activator of IFN-driven RIPK3 activation and perinatal lethality in the absence of RIPK1.

164 Perinatal lethality was observed in Slc7a7Lbu/Lbu and Sl

165 lation of TRADD rescues Ripk1(-/-) mice from perinatal lethality when RIPK3-mediated necroptosis is d

166 al deletion of both Crk and CrkL resulted in perinatal lethality with defects in desmosome morphology

167 Thm1 loss causes perinatal lethality, and Thm2 loss allows survival into

168 (NCCs) causes severe conotruncal defects and perinatal lethality, thus providing mouse genetic eviden

169 evere phenotype with reduced weight gain and perinatal lethality.

170 liver resulted in hematopoietic failure and perinatal lethality.

171 lting in intrauterine growth restriction and perinatal lethality.

172 tes, neuromuscular degenerative disease, and perinatal lethality.

173 se allele, Specc1lDeltaC510, that results in perinatal lethality.

174 romotion of influenza-induced PANoptosis and perinatal lethality.

175 hat Ly6c(Lo) monocytes promote resolution of perinatal liver inflammation in the late gestation fetus

176 tion may mitigate the detrimental effects of perinatal liver inflammation.

177 rrhosis and perinatal outcomes and evaluated perinatal liver-related events.

178 ence of clock synchrony and functionality in perinatal lung development, and the possibility of lung

179 ck biology is also likely to be important in perinatal lung development, where it has received far le

180 re screening, cyanotic heart disease, active perinatal lung disease, and preparation or recovery from

181 studies have focused on the adult lung, the perinatal lung remains unexplored.

182 Otherwise, there were no differences in perinatal, maternal, or obstetric parameters.

183 re more likely than those without to develop perinatal mental illness (18.1% vs. 16.0%; adjusted rela

184 We examined the risk of any perinatal mental illness associated with prepregnancy di

185 Modified Poisson regression estimated perinatal mental illness risk between conception and 1 y

186 Modified Poisson regression estimated perinatal mental illness risk between conception and 1 y

187 Perinatal mental illness risk was elevated in all classe

188 Perinatal mental illness risk was elevated in all classe

189 secting mechanistic interactions between the perinatal microbiota, immune system, and nervous system

190 defined LO disease as >7 days of life in the perinatal model.

191 Understanding the perinatal molecular clock may unravel mechanistic target

192 growth restriction (IUGR) is associated with perinatal morbidity and increased risk of lifelong disea

193 precedes preterm birth, the leading cause of perinatal morbidity and mortality worldwide.

194 orldwide and causes significant maternal and perinatal morbidity and mortality.

195 proposed in high-income countries to prevent perinatal morbidity and mortality.

196 ended pregnancy is associated with increased perinatal morbidity and mortality.

197 s (CS) translate into reduced maternal/child perinatal morbidity or mortality, CS have been increasin

198 y merit exploration as a factor impacting on perinatal morbidity.

199 , we also observed significant reductions in perinatal mortality (0.86 [0.73-1.00], p=0.048), fetal l

200 Preterm birth (PTB) is the leading cause of perinatal mortality and newborn complications.

201 the risk of overestimation of the effect on perinatal mortality due to early stopping of the largest

202 each chart achieved similar sensitivity for perinatal mortality in small infants (29% for all charts

203 The magnitude of risk reduction of perinatal mortality remains uncertain.

204 In the multivariable context, perinatal mortality was associated with only 3 of the 30

205 easing wealth (OR 1.09, 1.03-1.14) and lower perinatal mortality with increasing distance from childb

206 2008), whereas there was evidence for higher perinatal mortality with increasing wealth (OR 1.09, 1.0

207 stically significant variation was found for perinatal mortality.

208 reterm delivery before 37 weeks, and reduced perinatal mortality.

209 that have been relayed by hospital teams and perinatal networks.

210 In a rat model, perinatal nicotine exposure results in an epigenetically

211 f the ventral tegmental area (VTA) following perinatal nicotine exposure.

212 an overall decrease in DA neurons following perinatal nicotine exposure.

213 within the sub-regions of the VTA following perinatal nicotine exposure.

214 st protection from PVI dysfunction following perinatal NMDAR blockade.

215 1 medullar follicles during mouse fetal and perinatal oogenesis.

216 Patients with perinatal or infantile hypophosphatasia treated with asf

217 lted overall in a decrease of severe adverse perinatal outcome (0.4% [10/2,281] versus 1.0% [23/2,280

218 rs independently associated with any adverse perinatal outcome (APO).

219 imary outcome was a composite of maternal or perinatal outcome (either maternal, fetal, or neonatal d

220 ound that, overall, IOL at 41 weeks improved perinatal outcome compared with expectant management unt

221 The risk of severe adverse perinatal outcome was decreased for nulliparous women in

222 cases and were significantly associated with perinatal outcome, including hydrops, respiratory distre

223 ogether with a per-protocol analysis for the perinatal outcome.

224 igated the association between cirrhosis and perinatal outcomes and evaluated perinatal liver-related

225 An under-recognition of the perinatal outcomes and its associated factors might have

226 term births, factors associated with poorer perinatal outcomes and related management interventions.

227 age restrictions, for studies on maternal or perinatal outcomes following caesarean sections in LMICs

228 easing, although population-based data about perinatal outcomes following in utero exposure remain li

229 atabase inception to June 1, 2018, reporting perinatal outcomes for women with intrahepatic cholestas

230 tional study established in 2006 to evaluate perinatal outcomes in pregnant women exposed to omalizum

231 ., same- or mixed-sex) of litters influences perinatal outcomes in the common marmoset monkey (Callit

232 im to estimate the frequency of maternal and perinatal outcomes in women with different categories of

233 ursodeoxycholic acid does not reduce adverse perinatal outcomes in women with intrahepatic cholestasi

234 whether ursodeoxycholic acid reduces adverse perinatal outcomes in women with intrahepatic cholestasi

235 d active case finding, together with data on perinatal outcomes in women with these outcomes.

236 Adverse perinatal outcomes included macrosomia (multiple thresho

237 I 1.8-4.8, p < 0.001) and experience adverse perinatal outcomes including perinatal death, admission

238 Perinatal outcomes may vary according to lots of factors

239 ds associated with increased risk of adverse perinatal outcomes using population, customised, and Int

240 The strength of association with adverse perinatal outcomes was different between infants below t

241 Maternal and perinatal outcomes were also collected according to mate

242 Aggregate data for maternal and perinatal outcomes were extracted from case-control stud

243 sPTB and pi-PTb were associated with poorer perinatal outcomes, as well as late sPTB, late pi-PTB an

244 asis of pregnancy is associated with adverse perinatal outcomes, but the association with the concent

245 licated pregnancies at 41 weeks will improve perinatal outcomes.

246 hnologies (ARTs) are associated with adverse perinatal outcomes.

247 gnancy has not been associated with improved perinatal outcomes.

248 regnancy after bariatric surgery and adverse perinatal outcomes.

249 is is an independent risk factor for adverse perinatal outcomes.

250 ry outcome was a composite of severe adverse perinatal outcomes: mortality and severe neonatal morbid

251 xpressed in the same subset of germ cells in perinatal ovaries and Figla ablation dramatically disrup

252 analyzed global gene expression profiles in perinatal ovaries from wildtype, FiglaNull, Lhx8Null and

253 ten requires the expertise of an experienced perinatal pathologist.

254 ne biceps femoris skeletal muscle during the perinatal period and examined the role of thyroid hormon

255 that mitochondrial function matures over the perinatal period and is dependent on thyroid hormones, w

256 This work highlights the perinatal period as a critical time window, especially r

257 he mother and infant dyad may present in the perinatal period from 20 weeks of gestation to 28 days o

258 ants and testicular somatic cells during the perinatal period in mice.

259 p8(C362A/C362A)Mlkl(-/-) mice die during the perinatal period(5), whereas Casp8(-/-)Mlkl(-/-) mice ar

260 eydig and peritubular myoid cells during the perinatal period, allowing us to identify candidate sign

261 ess can have a devastating effect during the perinatal period, and has a profound impact on the care

262 environmental exposure, particularly during perinatal period, can have a life-long impact on organis

263 In the perinatal period, cardiomyocytes still proliferate, and

264 portance of proper choline intake during the perinatal period, especially when the fetus is known to

265 that early-life adversity, especially in the perinatal period, influences the maturation of brain cir

266 cells in a stage-specific manner during the perinatal period.

267 eonates scanned cross-sectionally across the perinatal period.

268 rm and somatic cell developmental during the perinatal period.

269 y important for brain development during the perinatal period.

270 associated with neuroanatomic changes in the perinatal period.

271 on offspring's glucose metabolism during the perinatal period.

272 diated inflammation and is lethal during the perinatal period.

273 relatively mild outcome to death during the perinatal period.

274 l long-term effects when administered during perinatal periods, increasing the risk to develop anxiet

275 uire analysis by a multidisciplinary team of perinatal practitioners and laboratory specialists.

276 se cellular immunoreactivity was assessed in perinatal, prepubertal, and adult female and male rats.

277 Complimentary, we demonstrated two-phased perinatal programming after IUGR.

278 at two study sites through the Collaborative Perinatal Project.

279 In cases without perinatal sentinel events, genomic alterations contribut

280 Here we tested the hypothesis that human perinatal stem cell derived extracellular matrix (ECM) p

281 iabetes could benefit from preconception and perinatal strategies to reduce their mental illness risk

282 lity to abnormal lentiform development after perinatal stress and are associated with neuroanatomic c

283 Our study thus demonstrates that perinatal stress can have long-term consequences on CD8

284 ficant relevance to pediatrics, in utero and perinatal stressors may alter the lifelong health trajec

285 wn to reduce preterm birth (PTB) and improve perinatal survival, but no trial evidence exists for wom

286 Perinatal T cells broadly access nonlymphoid tissues, wh

287 pening of anergy occurred after depletion of perinatal T reg cells.

288 We find that clonal expansions during a perinatal time window leave a long-lasting imprint on th

289 All patients had been infected through perinatal transmission and were treatment naive.

290 addition, there is evidence that over time, perinatal transmission has decreased among women and inf

291 ntify HBV-infected pregnant women at risk of perinatal transmission in countries where HBV DNA quanti

292 birth intervals, key strategies to eliminate perinatal transmission of HIV and promote maternal and c

293 n of HBV vaccine-based strategies to prevent perinatal transmission, safe injection practices and HCV

294 providing protective immunity and preventing perinatal transmission.

295 dentifies women whose infants are at risk of perinatal transmission.

296 on of HBV-infected pregnant women at risk of perinatal transmission.

297 Perinatal treatment with lopinavir boosted by ritonavir

298 This review will address the role of perinatal vascular insults in the development of late pu

299 We postulate that there is a critical perinatal window, ranging from embryonic day 18.5 to pos

300 izoxanide is a promising agent in preventing perinatal Zika transmission as well as other RNA viruses