ライフサイエンスコーパス: perinatally

1 skeleton; homozygous null mutant animals die perinatally.

2 ed into glioma when mutations are introduced perinatally.

3 veloped without gross abnormalities but died perinatally.

4 ly became enriched in islet and ductal cells perinatally.

5 display dramatically enlarged hearts and die perinatally.

6 eactive dopaminergic neurons, which are born perinatally.

7 C) axons to their appropriate central target perinatally.

8 whereas mice with a C57Bl/6J background die perinatally.

9 Pax3 and Pax7 embryonically, and Pax7 alone perinatally.

10 tion of the rostral cerebellum that develops perinatally.

11 Most ROCK1(-/-) mice die perinatally.

12 mummy mutants have red, scaly skin and die perinatally.

13 All the homozygous mice died perinatally.

14 s) or inbred (129S6) genetic background died perinatally.

15 lood and blood products, organ donation, and perinatally.

16 isruption of CARM1 are small in size and die perinatally.

17 mice also suffer from hydrocephalus and die perinatally.

18 isplay severe vascular abnormalities and die perinatally.

19 ransmission Study; 7 women transmitted HIV-1 perinatally.

20 ryos with mUPD12 can survive to term but die perinatally.

21 are runted at birth, fail to nurse, and die perinatally.

22 ETA2 gene developed severe diabetes and died perinatally.

23 iral therapy and 90 percent had acquired HIV perinatally.

24 s observed in Myf5-deficient mice, which die perinatally.

25 precursors and is subsequently up-regulated perinatally.

26 r the determination of the migratory pathway perinatally.

27 Most mice with both mutations died perinatally.

28 y-cKO) mice, in which Arc/Arg3.1 was deleted perinatally.

29 h sexual contact, nonsexual body fluids, and perinatally.

30 roups that may undergo wholesale elimination perinatally.

31 be transmitted through blood transfusion and perinatally.

32 ay; GD 9 - 18) for placental measurements or perinatally (0, 100, 300 or 1000 microg/day; GD 9 - PND

33 lymorphic HIV-1 was transmitted to patient X perinatally 15 years previously and has been maintained

34 enrolled in 2000 and 2001, 90% acquired HIV perinatally, 52% were girls, and 59% were black.

35 Most were treatment naive (98%) and infected perinatally (94%).

36 rus DNA levels in patients in their 40s with perinatally acquired hepatitis B virus infection increas

37 as much as 40% of men and 15% of women with perinatally acquired hepatitis B virus infection will di

38 ) and its mechanisms in children living with perinatally acquired HIV (PHIV) in sub-Saharan Africa ha

39 Female youth with perinatally acquired HIV (PHIV) may be at higher risk th

40 f subclinical CVD risk, in youth living with perinatally acquired HIV (YLPHIV).

41 Young adults with perinatally acquired HIV (YPHIVs) living in the United S

42 Diagnosis of perinatally acquired HIV infection in infants born in th

43 The growing population of adolescents with perinatally acquired HIV infection living within this re

44 Perinatally acquired HIV infection occurs during a criti

45 ren are living into their teenage years with perinatally acquired HIV infection, and we now find ours

46 ize in the peripheral blood of children with perinatally acquired HIV-1 infection.

47 ation, and immune responses in children with perinatally acquired HIV-1 infection.

48 Young adolescents with perinatally acquired human immunodeficiency virus (HIV)

49 lts.Despite viral suppression, children with perinatally acquired human immunodeficiency virus (HIV)

50 nitive performance of older adolescents with perinatally acquired human immunodeficiency virus (HIV)

51 Children with perinatally acquired human immunodeficiency virus (HIV;

52 Female youth with perinatally acquired human immunodeficiency virus (PHIV)

53 Older children and adolescents with perinatally acquired human immunodeficiency virus (PHIV)

54 Hispanic ethnic background, younger age, and perinatally acquired infection were associated with a lo

55 resting CD4(+) T cells from 21 children with perinatally acquired infection.

56 Young adolescents with perinatally-acquired HIV are at risk for poor care outco

57 Perinatally-acquired HIV has persistent effects on long-

58 as been reported among African children with perinatally-acquired HIV infection (C-PHIV), despite com

59 Adolescents with perinatally-acquired HIV infection (PHIVA) should be a f

60 he epigenome are detectable in children with perinatally-acquired HIV infection on suppressive ART st

61 lower lung function among youth living with perinatally-acquired HIV, despite antiretroviral therapy

62 have excellent sensitivity for diagnosis of perinatally-acquired infection at age 2-6 months and cou

63 ests whether exogenous bombesin or GRP given perinatally alters alveolar development in newborn mice.

64 Perinatally, an increase in the proliferation of endocri

65 (13) vg/kg) established 4.2-41.3% expression perinatally and 9.8-25.3% over 46 mo.

66 indicator genes in individual cardiomyocytes perinatally and after inducing cardiac hypertrophy by tr

67 TGFbetaIr was expressed by glia perinatally and by all cell types in weanlings.

68 hest levels of proBDNF and p75 were observed perinatally and declined, but were still detectable, in

69 tial myotubes, and Minion-deficient mice die perinatally and demonstrate a marked reduction in fused

70 scle mutants have reduced muscle miRNAs, die perinatally and display decreased skeletal muscle mass a

71 Mena-/-VASP-/- double mutants die perinatally and display defects in neurulation, craniofa

72 We find that mice deficient for CXCR4 die perinatally and display profound defects in the hematopo

73 gulated being developmentally down-regulated perinatally and enriched at neuromuscular junctions (NMJ

74 egulatory Factor 6 (Irf6)-deficient mice die perinatally and exhibit ectopic proliferation and defect

75 development because Hic1-deficient mice die perinatally and exhibit gross developmental defects thro

76 Arnt2(-/-) embryos die perinatally and exhibit impaired hypothalamic developmen

77 These animals die perinatally and exhibit varying combinations of gross de

78 cking the dHAND branchial arch enhancer died perinatally and exhibited a spectrum of craniofacial def

79 expressed the transgene at high levels, died perinatally and exhibited replacement fibrosis.

80 model, we find that most Apaf-1 mutants die perinatally and frequently exhibit exencephaly and crani

81 Since Bmp7 homozygous mutants die perinatally and heterozygotes do not show obvious defect

82 d alpha7C was present extrasynaptically both perinatally and in adulthood.

83 exhibits an increase in density in area CA1 perinatally and is characterized by a dense, diffuse ban

84 arts at embryonic day 9, reaches peak levels perinatally and is downregulated during postnatal develo

85 Osteocalcin gene expression is initiated perinatally and is restricted to mature osteoblasts and

86 but enriched in brain, its expression peaks perinatally and it undergoes extensive alternative splic

87 re lung-resident sentinel cells that develop perinatally and protect against pulmonary infection.

88 d pool of primordial oocytes that are formed perinatally and remain arrested till ovulation.

89 Emp null embryos die perinatally and show profound alterations in the hematop

90 were concordantly HIV-1-infected in utero or perinatally and then to examine strain divergence or vir

91 ing maternal-to-fetal transmission of HIV-1, perinatally and through breastfeeding.

92 This intrabulbar map forms perinatally and undergoes activity-dependent refinement

93 ing neurons of the murine bowel appear late (perinatally) and are mash-1 independent.

94 Four patients died perinatally, and 11 survived.

95 Perinatally, and between menarche and menopause, increas

96 Homozygotes died perinatally, and E18.5 embryos exhibited striking develo

97 cytes) appear in the embryonic brain, expand perinatally, and persist widely throughout the gray and

98 tic deficiency of PSR in the mouse is lethal perinatally, and results to date have been ambiguous wit

99 (W-sh/W-sh) mice with adult male, female, or perinatally androgenized female MCs results in MC-mediat

100 ry system function in rats that were briefly perinatally anoxic.

101 In two perinatally antiretroviral drug treated HIV-1-infected g

102 lbino Tyr; c locus that also include Fah die perinatally as a result of liver dysfunction and exhibit

103 Tcof1 heterozygous mice die perinatally as a result of severe craniofacial anomalies

104 Approximately half of ERdj4(GT/GT) mice died perinatally associated with fetal growth restriction, re

105 Mice homozygous for this deletion die perinatally because of defects in craniofacial morphogen

106 ha7B was present throughout the muscle fiber perinatally, becoming confined to the synapse in the sec

107 Ret expression is extinguished perinatally but reemerges postnatally in a subpopulation

108 ARG is activated in the liver perinatally, but is expressed at very low levels.

109 ron migration delay that is evident pre- and perinatally, but is not detected at postnatal day 35 (P3

110 at5a/b(-/-) mice are severely anemic and die perinatally, but no link has been made to iron homeostas

111 homozygous for the disrupted Psip1 gene died perinatally, but some survived to adulthood and displaye

112 in mothers who did and did not transmit HIV perinatally by using a DNA heteroduplex mobility assay.

113 Perinatally, c-neu immunoreactivity was evident in subpl

114 As expected, perinatally cocaine-exposed offspring spent less time im

115 src and yes move and breathe poorly and die perinatally, consistent with defects in neuromuscular fu

116 Second, Osterix-expressing cells perinatally contribute to osteolineages and long-lived B

117 ng proportion of peripherally, as opposed to perinatally derived AMs.

118 Four with hydrops at presentation died perinatally, despite initial improvement in function in

119 Perinatally, development and grade of CLD were further i

120 The mutant embryos that survive die perinatally, displaying an extensive array of malformati

121 these YAC-rescued Gata2 null mutant mice die perinatally due to defective urogenital development.

122 The majority of ACLP(-/-) mice die perinatally due to gastroschisis, a severe disruption of

123 3, the murine homologue of human SPINK1, die perinatally due to massive pancreatic acinar cell death,

124 Perinatally, ECMO requirement and gestational age at del

125 romotes cell survival-mice lacking RIPK1 die perinatally, exhibiting aberrant caspase-8-dependent apo

126 usly reported that SEC23B-deficient mice die perinatally, exhibiting massive pancreatic degeneration

127 usly reported that SEC23B-deficient mice die perinatally, exhibiting massive pancreatic degeneration,

128 Mice with germline absence of SEC23B die perinatally, exhibiting massive pancreatic degeneration.

129 antiretroviral therapy and compared them to perinatally exposed but uninfected children.

130 The percentage of perinatally exposed children born from 1993 through 1997

131 nce standard in identifying HIV infection in perinatally exposed children.

132 Mecp2(308/+) dams were perinatally exposed daily to 2,2',4,4'-tetrabromodipheny

133 IV) diagnosis in 345 prospectively followed, perinatally exposed infants.

134 suspected transient HIV-1 viremia among 1562 perinatally exposed seroreverting infants and one mother

135 type (WT) and SXRKO mice were chronically or perinatally exposed to a low dose (54 mug/kg/d) of PCB-1

136 as observed specifically in female offspring perinatally exposed to BDE-47 and it coincided with redu

137 Adult mice perinatally exposed to DDT exhibited chronically increas

138 ril completely reversed hypertension in mice perinatally exposed to DDT.

139 asthma-like phenotype, the offspring of mice perinatally exposed to LPS was significantly protected.

140 SXRKO mice perinatally exposed to PCB-153 displayed elevated oxidat

141 toxically dysfunctional NK cells relative to perinatally exposed uninfected children.

142 /2008 to 6/30/2018 were reviewed to identify perinatally-exposed infants tested by HCV-RNA RT-PCR at

143 During the study period, 770 perinatally-exposed infants underwent HCV-RNA testing at

144 While Bin1-/- mice die perinatally from a skeletal muscle defect, Bin1-/- Dnm2+

145 e homozygous for a null mutation of Hrt2 die perinatally from a spectrum of cardiac abnormalities, ra

146 omozygous for the Notch2(del1) mutation died perinatally from defects in glomerular development in th

147 esting in a family in which a child had died perinatally from renal vein thrombosis.

148 at normally express the protein and they die perinatally from respiratory insufficiency.

149 crest conditional Pinch1 mutant embryos die perinatally from severe cardiovascular defects with an u

150 genetic backgrounds, homozygous mutants die perinatally from severe hydrocephalus, while mice on oth

151 at the anaconda juveniles acquired the virus perinatally from the anaconda mother rather than from ot

152 xpanded thymic and peripheral populations of perinatally generated IL-17A(+)Vgamma6(+)Vdelta1(+) T ce

153 ative comparison of immunoreactivity in rats perinatally gonadectomized or sham-operated revealed com

154 ion on changes in lung function over time in perinatally HIV+ adolescents on HAART.

155 we describe features of virus and host of a perinatally HIV-1 infected child with long-term sustaine

156 ide improved protection against influenza in perinatally HIV-1-infected children and youth.

157 developed world, and a growing proportion of perinatally HIV-1-infected children are now entering the

158 As perinatally HIV-1-infected children grow into adolescent

159 V-1-infected adults, the role of NK cells in perinatally HIV-1-infected children is less studied.

160 of cART during the first 12 weeks of life in perinatally HIV-1-infected children limits the size of t

161 f NK cell subsets in the peripheral blood of perinatally HIV-1-infected children on highly active ant

162 This retrospective study included 23 perinatally HIV-1-infected children who initiated very e

163 virin) were administered 21-28 days apart to perinatally HIV-1-infected children, adolescents, and yo

164 In perinatally HIV-1-infected newborns, initiation of cART

165 mbination antiretroviral therapy (cART) in 4 perinatally HIV-1-infected youth who received treatment

166 ral blood mononuclear cells (PBMCs) among 61 perinatally HIV-1-infected youths in the Pediatric HIV/A

167 o estimate seroimmunity in PHIV-infected and perinatally HIV-exposed but uninfected (HEU) children an

168 bservational study of children with PHIV and perinatally HIV-exposed but uninfected (PHEU) children c

169 ty of phagocytes from HIV-infected children, perinatally HIV-exposed but uninfected children, and nor

170 ountries have suggested impaired immunity in perinatally HIV-exposed uninfected children (HEU), with

171 between perinatally HIV-infected (PHIV) and perinatally HIV-exposed, uninfected (PHEU) youth.

172 othesized that the oral microbiota of HI and perinatally HIV-exposed-but-uninfected (HEU) children wi

173 and 18 and rate of abnormal cytology between perinatally HIV-infected (PHIV) and perinatally HIV-expo

174 Perinatally HIV-infected (PHIV) children and adolescents

175 A total of 296 perinatally HIV-infected (PHIV+) and 97 HIV- adolescents

176 Forty-eight percent and 24% of the perinatally HIV-infected adolescents had coronary arteri

177 Perinatally HIV-infected adolescents may be susceptible

178 al aorta PDAY scores were calculated for 165 perinatally HIV-infected adolescents, using a weighted c

179 in CD32-CD4+ T cells in virally suppressed, perinatally HIV-infected adolescents, which has implicat

180 latent HIV reservoir in virally suppressed, perinatally HIV-infected adolescents.

181 mpare total body fat and its distribution in perinatally HIV-infected and HIV-exposed but uninfected

182 A perinatally HIV-infected child now faces a chronic disea

183 Here we describe a perinatally HIV-infected child who maintained a plasma v

184 In total, 35 perinatally HIV-infected children (median age, 13.8 year

185 This cross-sectional study included perinatally HIV-infected children and controls matched f

186 Among perinatally HIV-infected children born in 2002-2013, 836

187 ardiac structure and function were better in perinatally HIV-infected children exposed to HAART than

188 revalence of asthma have been documented for perinatally HIV-infected youth 10 to 21 years of age com

189 A substantial proportion of perinatally HIV-infected youth have high PDAY scores, re

190 Survival into adulthood of perinatally HIV-infected youth in high-resource countrie

191 ever, these successes pose new challenges as perinatally HIV-infected youth survive into adulthood.

192 CD4 counts in perinatally HIV-infected, therapy-naive children in the

193 ountries have suggested impaired immunity in perinatally human immunodeficiency virus (HIV)-exposed u

194 ation antiretroviral therapy (cART)-treated, perinatally human immunodeficiency virus (HIV)-infected

195 ted with initiation of sexual activity among perinatally human immunodeficiency virus (HIV)-infected

196 gh-dose pandemic H1N1 (pH1N1) vaccination in perinatally human immunodeficiency virus type 1 (HIV-1)-

197 Pregnancy outcomes of perinatally human immunodeficiency virus-infected women

198 As perinatally human immunodeficiency virus-infected youth

199 n the background of evolutionary engraved or perinatally imprinted physiological response patterns is

200 nerically, they will be readily identifiable perinatally in congenital diaphragmatic hernia (CDH), wh

201 Primordial follicles are formed perinatally in mammalian ovaries and at birth represent

202 convincingly argues that genomic plasticity perinatally induced by the environment creates a complic

203 opsychological outcomes longitudinally among perinatally infected African children who received early

204 zation of HIV-1-specific CD8 responses in 18 perinatally infected children (age range, 6 to 17 years)

205 Studies in perinatally infected children are lacking.

206 the evolution of viral sequences within six perinatally infected children by examining proviral sequ

207 ripheral blood mononuclear cells (PBMC) from perinatally infected children from the Children with HIV

208 We studied the immune response of perinatally infected children to an epitope (B57-TW10) t

209 A total of 110 perinatally infected children were studied.

210 Together, these data indicate that perinatally infected children who survive infancy mount

211 pid disease progression to AIDS and death in perinatally infected children.

212 nt and the natural history of HIV disease in perinatally infected children.

213 edian levels were 355,000 copies/mL among 52 perinatally infected infants and 130,000 copies/mL among

214 The estimated annual number of perinatally infected infants born in the United States d

215 genes obtained from seven mothers and their perinatally infected infants in Sweden were studied.

216 In perinatally infected infants, HIV-1 RNA levels are high

217 fection and replication in mothers and their perinatally infected infants.

218 immunodeficiency virus type 1 (HIV-1) RNA in perinatally infected infants.

219 compared with DNA-PCR for early detection of perinatally infected infants.

220 the current immune and virological status of perinatally infected patients reaching adulthood.

221 cterized Gag-specific CD4 responses among 35 perinatally infected subjects, including 2 children who

222 lly confirmed resistance transmission from a perinatally infected teenage male to a newly infected te

223 Heterozygotic perinatally infected twins with a marked difference in t

224 2233 children < or =13 years of age who were perinatally infected with HIV and were receiving > or =2

225 this small study in children and adolescents perinatally infected with HIV with low LS BMD, 48 weeks

226 children and adolescents (aged 11-24 years) perinatally infected with HIV with low lumbar spine (LS)

227 en orthotopic gliomas were implanted in mice perinatally infected with MCMV versus controls.

228 yngeneic GBM models were established in mice perinatally infected with MCMV.

229 me from their gliomas than control Mut3 mice perinatally infected with mock or with a different neuro

230 It is unclear if children perinatally infected with the human immunodeficiency vir

231 After at least 15 years of HIV infection, perinatally infected youths had preserved CD4N and CD4RT

232 In perinatally infected youths who are successfully treated

233 ered care at younger than 15 years (probably perinatally infected) or at 15-19 years (probably infect

234 e followed 69 HIV-positive patients who were perinatally infected.

235 Hispanic, 55% US-born, 20% refugees, and 64% perinatally infected.

236 Among 1201 HIV-infected youth in P1074 (87% perinatally infected; mean [standard deviation] age at l

237 he temporal structure of ANS fluctuations is perinatally influenced.

238 ocal output and its sequential structure are perinatally influenced.

239 Cerebral inhibition develops perinatally, influenced by genetic and in utero factors.

240 Because Cx43-/- mice die perinatally, initial analyses were performed on Cx43-/-,

241 17me2a mark in vitro CARM1 knockout mice are perinatally lethal and display a reduced fetal size, whe

242 The mutant mice are perinatally lethal and exhibit a wide range of developme

243 MICU1 knockout is perinatally lethal in mice without causing gross anatomi

244 FXR1 depletion is perinatally lethal in mice, Xenopus, and zebrafish; howe

245 A naturally occurring, recessive, perinatally lethal mutation in the aggrecan core protein

246 mutations (Psen1(LF/LF) ) are embryonic and perinatally lethal, precluding a more rigorous examinati

247 able phenotype, the STIM1/STIM double-KO was perinatally lethal, revealing an essential role of STIM1

248 cTnI(146Gly) levels >40% of total cTnI were perinatally lethal, whereas replacement levels of 15% to

249 mation in genetically modified mice that are perinatally lethal.

250 Although Lgr4KO and Lgr5KO mice both died perinatally, Lgr5 deletion did not compromise embryonic

251 Most adam19(-/-) animals die perinatally, likely as a result of their cardiac defects

252 mice which have high serotonin (5-HT) levels perinatally, neurons in the lateral superior olive (LSO,

253 ing autophagy, and Ulk1/2-deficient mice die perinatally of autophagy-related defects.

254 Egr2-null mice die perinatally of respiratory insufficiency characterized b

255 n contrast to kindlin-3-null mice, which die perinatally of severe bleeding and leukocyte adhesion de

256 apie can transmit laterally from ewe to lamb perinatally or between adult animals.

257 Chronic hepatitis B (CHB) infection acquired perinatally or in early childhood has been associated wi

258 ther-to-infant transmission, which may occur perinatally or postnatally, as a consequence of breast f

259 did not significantly differ among in utero, perinatally, or postnatally infected infants.

260 ratified as having occurred either in utero, perinatally, or postnatally.

261 We show that perinatally, Pax6(sey/sey) mice, which lack functional P

262 of the dystroglycanopathy spectrum but died perinatally precluding its full phenotyping and use in t

263 Homozygous mutant mice die perinatally showing a greatly distended bladder, underde

264 Because most bak(-/-)bax(-/-) mice die perinatally, the roles of Bax and Bak in immunological t

265 = 6, 3.12 x 10(13) vg/kg) increased from <1% perinatally to 9.8-13.4% >35 mo.

266 Interleukin-33 acts perinatally to ensure adaptive thermogenesis lifelong.

267 Hamsters exposed perinatally to short days (8 hr light/day) exhibited mix

268 Early diagnosis of perinatally transmitted human immunodeficiency virus typ

269 Because Egfr-/- mice die perinatally, transplantation methods were used to study

270 These perinatally treated rats were then reared to adulthood (

271 others expressing HLA-B27 who transmit HIV-1 perinatally, we document transmission of viruses encodin

272 ause mice lacking the Pcdh-gamma cluster die perinatally, we generated conditional mutants to analyze

273 se most children are believed to be infected perinatally, we have developed a model of HIV CNS infect

274 9 Ugandan mothers who received NVP treatment perinatally were sampled 6 weeks postdelivery.

275 Importantly, the viruses transmitted perinatally were those with enhanced fitness due to reve

276 Nine pediatric patients who acquired HIV perinatally were treated with multidrug combinations of

277 , alpha4, and alpha5 mRNAs expression peaked perinatally, whereas alpha6 and beta3 levels increased w

278 e external plexiform layer are produced only perinatally, whereas the generation of 5T4-positive gran

279 hepatitis B (CHB) usually acquire the virus perinatally, while most patients infected during adultho

280 Pregnant Long-Evans rats were dosed perinatally with 0 or 30.6 mg/kg/day of DE-71 from gesta

281 e show that Foxd3(flox/-); Wnt1-Cre mice die perinatally with a catastrophic loss of neural crest-der

282 The majority of Casp9 knockout mice die perinatally with a markedly enlarged and malformed cereb

283 Homozygotes die perinatally with a severe peripheral nerve/axon defect a

284 Tbx1(+/-); Pitx2(+/-) mice died perinatally with cardiac defects, including double outle

285 The Sox9(+/-) mice died perinatally with cleft palate, as well as hypoplasia and

286 Here we report that AP-2(-/-) mice died perinatally with cranio-abdominoschisis and severe dismo

287 nt mice lacking all three MALS isoforms died perinatally with difficulty breathing and impaired excit

288 he majority of bax(-/-)bak(-/-) animals died perinatally with fewer than 10% surviving into adulthood

289 In some infants infected perinatally with HIV, a pattern of lymphocyte depletion

290 onged the survival time of children infected perinatally with HIV.

291 2.6 y (range: 5.9-15.2 y) who were infected perinatally with HIV.

292 Increasing numbers of children infected perinatally with human immunodeficiency virus (HIV) are

293 20 proteins in A20's ZF4 and ZF7 motifs died perinatally with multi-organ inflammation.

294 of EGFR signaling, and Adam17(-/-) mice die perinatally with open eyes, like Egfr(-/-) mice.

295 m17(-/-) and Egfr(-/-) mice in that they die perinatally with open eyes, misshapen heart valves, and

296 otwithstanding, NaChalpha(II)(-/-) mice died perinatally with severe hypoxia and massive neuronal apo

297 and most compound heterozygotes, die pre- or perinatally with similar abnormal phenotypes, including

298 d Jaws (joints abnormal with splitting), die perinatally with striking skeletal defects, including ec

299 ion-activating gene 1-deficient mice treated perinatally with vancomycin or streptomycin by repeated

300 n which only one copy of Nmyc is deleted die perinatally, with similarly abnormal lungs.