ライフサイエンスコーパス: periocular

1 is study demonstrates the efficacy of focal, periocular 2-DG as an adjunct to carboplatin chemotherap

2 was treated with topical (18/21, 86%) and/or periocular (4/21, 19%) corticosteroids.

3 Lid and periocular abnormalities, ocular surface pathologies, ne

4 eyelid swelling or a mass (10/14 cases), and periocular ache (5/14 cases).

5 low level of symptom burden mainly eliciting periocular ache (in 52% of treated group and 5% of place

6 kinetics of small lipophilic molecules after periocular administration can be described by compartmen

7 the corneal and retinal data obtained after periocular administration of 3 mg of celecoxib (a select

8 n corneal and retinal pharmacokinetics after periocular administration.

9 ed a dose-response relationship; P < 0.001), periocular (aHR, up to 7.96; P < 0.001), and intraocular

10 delivery and the unexpected omission of the periocular airpuff that served as the instructive signal

11 uli were novel or if they predicted that the periocular airpuff was about to be presented.

12 e observed that climbing fibers activated by periocular airpuffs also responded to stimuli from other

13 mice and measured their calcium responses to periocular airpuffs that serve as instructive stimuli du

14 HSV-1 periocular and eyelid disease was also more severe in ma

15 terature provides high-quality evidence that periocular and intraocular corticosteroid therapies are

16 sistently demonstrated that all investigated periocular and intraocular corticosteroid therapies impr

17 be well-tolerated and effective for treating periocular and orbital BCC in about half of all cases.

18 a all possible routes (topical, intraocular, periocular and systemic), and the scleral perforation co

19 toma, including intravenous, intra-arterial, periocular, and intravitreal techniques.

20 in disorder (PEPD), characterized by rectal, periocular, and perimandibular pain.

21 Treatment includes intravitreal, periocular, and systemic antibiotics.

22 Previously we showed that periocular angioblasts and forming ocular blood vessels

23 xually transmitted MC or with MC only in the periocular area were excluded.

24 Specimens from the ocular and periocular areas were collected from a total of 332 pati

25 e, complication rates and overall outcome of periocular basal cell carcinoma (BCC) in the Department

26 nd 1 patient (1 malignancy) also developed a periocular basal cell carcinoma.

27 Margin-controlled excision for periocular BCC and close follow-up after excision for me

28 s for all patients who underwent surgery for periocular BCC between January 2016 and December 2020 we

29 of identification of aggressive subtypes of periocular BCC in biopsies was 47.7%.

30 th locally advanced or metastatic orbital or periocular BCC or basal cell nevus syndrome and can obvi

31 th locally advanced or metastatic orbital or periocular BCC or basal cell nevus syndrome treated with

32 h locally advanced and metastatic orbital or periocular BCC treated with vismodegib in 2012-2017 at 2

33 eristics were noted in primary and recurrent periocular BCC, implying that incomplete surgical excisi

34 hip to proliferative activity in non-nodular periocular BCC, SEB and SCC.

35 e on vismodegib therapy for locally advanced periocular BCC.

36 rds more women than men being diagnosed with periocular BCC.

37 ons; (2) elimination via the conjunctival or periocular blood and lymphatic systems contributes signi

38 rcent of patients had required treatment for periocular cancers and 2% for ocular surface cancers.

39 meetings discussing patients with ocular and periocular cancers, over a 12-months period, was carried

40 ngle-modality, and combination therapy using periocular carboplatin and 2-deoxy-d-glucose (2-DG).

41 cal vitreous seeds and additional concurrent periocular carboplatin in patients with diffuse vitreous

42 rimary high-dose chemotherapy and concurrent periocular carboplatin, and EBRT selectively in chemothe

43 Current globe-sparing therapies, including periocular carboplatin, selective ophthalmic artery chem

44 us vincristine for one course, with optional periocular carboplatin.

45 Periocular celecoxib microparticles are useful sustained

46 The periocular celecoxib-PLGA microparticles are safe and do

47 advances in the diagnosis and management of periocular cellulitis and to alert physicians to emergin

48 Periocular cellulitis remains an important and common en

49 Periocular chemotherapy is employed to boost local chemo

50 d 21 treated with OAC plus intravitreous and periocular chemotherapy).

51 s seed clouds with OAC and intravitreous and periocular chemotherapy, compared with OAC alone, result

52 his study aimed to discuss severe ocular and periocular complications after dermatological laser trea

53 ating, disfiguring, and potentially blinding periocular condition for which no Food and Drug Administ

54 C57BL/6J mice received weekly periocular conjunctival fornix injections of a dexametha

55 alysis, we redefined the cellular origins of periocular connective tissues interacting with the EOMs,

56 One group (n = 16), was injected with periocular corticosteroid (400 mug in 10 microL).

57 inclusion because the studies (1) evaluated periocular corticosteroid injection, intraocular cortico

58 se of topical corticosteroids 2 times/d or 4 periocular corticosteroid injections.

59 Intravitreal and periocular corticosteroids are also recommended.

60 t use of prednisone >7.5 mg/day (aHR, 1.86); periocular corticosteroids in the last 3 months (aHR, 2.

61 Iris JXG responds to topical or periocular corticosteroids, often with stabilization or

62 Periocular crow's feet lines and horizontal forehead lin

63 nd topical medications can induce ocular and periocular cutaneous adverse effects (AEs), ranging from

64 ents with the tissue diagnosis of ocular and periocular cutaneous and mucocutaneous non-LCH disorders

65 Both intravitreous and periocular delivery of CGC-11144 also caused significant

66 Periocular delivery of the polyamine analogues may be a

67 om the choroid and the anterior segment; the periocular depot location determines the predominant dif

68 id/retina by transscleral diffusion from the periocular depot.

69 e of recovery at 1 month, whereas the use of periocular dexamethasone injections (cRR, 0.05 [0.02-0.6

70 fected STING(-/-) mice also showed increased periocular disease and increased corneal and trigeminal

71 porter activity was followed by the onset of periocular disease on day 4.

72 In addition, no periocular disease symptoms were observed.

73 riocular tissue was promoted by US11, as was periocular disease.

74 Retinal pharmacokinetics after periocular drug administration can be explained with a f

75 gly, conditional deletion of beta-catenin in periocular ectoderm results in the formation of Prox-1 a

76 athway reporter TOPGAL is expressed in nasal periocular ectoderm, these data suggest that, in this lo

77 early lethality, as well as microphthalmia, periocular edema and absence of the anterior chamber of

78 His symptoms included right eye proptosis, periocular edema and redness.

79 tand the associations of the ocular surface, periocular environment, and dry eye-related symptoms amo

80 All cases presented with pain and periocular erythema increasing over approximately 1 week

81 ons and Relevance: Half of the patients with periocular facial dystonias used alleviating maneuvers.

82 pace and cornea, with a dissolution step for periocular formulation) model, with parallel elimination

83 ravitreal treatment groups compared with the periocular group (HR, 1.83; 95% CI, 0.91-3.65 and HR, 2.

84 ed astigmatism and amblyopia associated with periocular hemangiomas while minimizing side effects.

85 temic beta-blockers to promote regression of periocular hemangiomas.

86 ochemistry is a useful diagnostic marker for periocular histiocytoses and to further characterize the

87 ical stain is a useful diagnostic marker for periocular histiocytoses, correlating with underlying mu

88 lthough wearing facemasks resulted in higher periocular humidity levels compared with not wearing fac

89 compared symptoms and signs across levels of periocular humidity, dry eye severity, facemask type, an

90 , meibography, tear film interferometry, and periocular humidity.

91 Nine infants with periocular IH were treated with propranolol (oral) for 2

92 then used as a bioassay to determine whether periocular immune modulation affects intraocular transge

93 abial fold in 9 cases (4%); face in 2 cases; periocular in 2 cases; and lip, eyebrow, cheek, and uppe

94 the medical literature on new treatments for periocular infantile (capillary) hemangioma.

95 ropranolol (3 mg/kg/day) in the treatment of periocular infantile hemangioma (IH) based on clinical a

96 ors that could be associated with ocular and periocular infection were collected by using structured

97 Majority of ocular and periocular infections in this study were caused by bacte

98 total 332 study participants with ocular and periocular infections, 198(60%) were culture positive.

99 o determine bacterial etiology of ocular and periocular infections, antimicrobial susceptibility prof

100 roups experienced a significant reduction in periocular inflammation, the radiotherapy-treated group

101 Sarcoidosis is a major cause of ocular or periocular inflammation.

102 y drug drops (321 [27%]), and intraocular or periocular injectable steroids (189 [15%]).

103 914 patients (1192 eyes) who received >/= 1 periocular injection during follow-up, 286 (31.3%) were

104 Posterior periocular injection led to much lower levels.

105 tial in all three compartments 20 days after periocular injection of 25% microspheres.

106 reous peak of 0.99 +/- 0.26 mug . h/mL after periocular injection of 5 mg of fluorescein (P < 0.01 fo

107 ous were measured either 10 or 20 days after periocular injection of 50% PKC microspheres or at 20 da

108 Ten days after periocular injection of 50% PKC412 microspheres, PKC412

109 Twenty days after periocular injection of 50% PKC412, high levels of PKC41

110 in tumor burden was detected after a single periocular injection of anecortave acetate.

111 ere given intraperitoneal, intravitreous, or periocular injection of CGC-11144, CGC-11150, or vehicle

112 Within 2 days of periocular injection of CGC-11144, there was apoptosis i

113 membrane in young domestic pigs, and then a periocular injection of control microspheres or microsph

114 Within 20 minutes of a periocular injection of fluorescein, peak fluorescence w

115 ignificantly smaller in eyes that received a periocular injection of microspheres containing 25% (P=0

116 New Zealand White rabbits were given a periocular injection of sodium fluorescein (fluorescein,

117 levels are markedly increased compared with periocular injection of the same amount of fluorescein.

118 The patient underwent periocular injection of triamcinolone acetonide, with re

119 ructures compared with other intraocular and periocular injection procedures.

120 nterior subconjunctival injection, posterior periocular injection, intramuscular injection, or topica

121 reduced in the exoplant group compared with periocular injection.

122 ibutes significantly to drug clearance after periocular injection; (3) corneal pharmacokinetics of sm

123 Periocular injections and surgically implanted drug rese

124 area of CNV, with a similar reduction after periocular injections of 0.2 mg CGC-11144 three times a

125 (Pharmacia & Upjohn Co, Bridgewater, NJ) and periocular injections of botulinum toxin A.

126 or anterior uveitis is well-established, but periocular injections of corticosteroid can also be used

127 Periocular injections of d,l-alpha-difluoromethyl-ornith

128 vitreous cavity of newborn rats, followed by periocular injections of EDL-155 (20 mg/kg/day) or an eq

129 ng protein 1177-1191 peptide were treated by periocular injections of increasing doses of MSC-Exo sta

130 Same-aged mice (n = 30) received periocular injections of saline, carboplatin, and 2-DG.

131 ) transgenic mice (n = 25) were treated with periocular injections of varying doses of 2-DG (62.5, 12

132 sgenic retinoblastoma mice were treated with periocular injections to the right eye only of saline (n

133 Periocular injections were effective in treating active

134 vitreous (melphalan, topotecan) or topotecan periocular injections.

135 To evaluate the pharmacokinetics of the periocular injections: posterior subtenon (PST), retrobu

136 This study aimed to explore ocular and periocular injuries resulting from animal and bird attac

137 hort, which included persons with ocular and periocular injuries with or without facial injuries, and

138 nimal and bird, the nature of the ocular and periocular injuries, details of ophthalmological examina

139 % of patients sustained associated ocular or periocular injuries, including eyelid lacerations (17.6%

140 male and 4 male patients were diagnosed with periocular lobular capillary hemangioma at a median age

141 The authors provide a summary of traditional periocular locations for the injection of neuromodulator

142 Nine patients developed 12 periocular malignancies and 3 patients required eyelid s

143 sexpression also leads to a reduction of the periocular mesenchymal cell population expressing Lmx1b,

144 meobox gene Six3 is expressed in a subset of periocular mesenchymal cells and in differentiating ante

145 and lmx1b.2 result in defective migration of periocular mesenchymal cells around the eye and lead to

146 ed levels of Six3 attenuate proliferation of periocular mesenchymal cells in vitro and differentiatin

147 opment, keratocan mRNA was first detected in periocular mesenchymal cells migrating toward developing

148 lmx1b.1 and lmx1b.2 promote the survival of periocular mesenchymal cells that influence multiple sig

149 s expressed in the dermis, skeletal muscles, periocular mesenchymal-like cells and corneal endotheliu

150 ion abolishes hedgehog (Hh) signaling in the periocular mesenchyme (POM) canonically activated by cho

151 results in ectopic blood vessels within the periocular mesenchyme and PITX2 expression remains persi

152 cranial neural crest that gives rise to the periocular mesenchyme and the frontonasal process, retin

153 These defects in the periocular mesenchyme are correlated with a failure in f

154 Structures derived from periocular mesenchyme arise by complex interactions betw

155 Disruptions to either the matrix or periocular mesenchyme can cause defects in early eye dev

156 strated the interaction of beta 1 and NG2 in periocular mesenchyme cells and corneal fibroblasts with

157 ynamically in the developing vasculature and periocular mesenchyme during development.

158 losure, is dramatically downregulated in the periocular mesenchyme in late VAD embryos, and dissoluti

159 Indeed, by blocking the death of the periocular mesenchyme in Lmx1b morphants, optic vesicle

160 euroectoderm, lens, and neural crest-derived periocular mesenchyme induced severe eye abnormalities w

161 m, but their function in the Fgf10-producing periocular mesenchyme is still poorly understood.

162 Conditional inactivation of Porcn in periocular mesenchyme led to defects in mid- and hindbra

163 pment or function of structures derived from periocular mesenchyme result in debilitating vision loss

164 results in agenesis or severe disruption of periocular mesenchyme structures and extrinsic defects i

165 In the lens, retina and periocular mesenchyme, G8-positive cells synthesized Myo

166 In mouse embryos Rieg mRNA localized in the periocular mesenchyme, maxillary and mandibular epitheli

167 ssues, including prechondrogenic mesenchyme, periocular mesenchyme, meninges, endothelial cells, and

168 The periocular mesenchyme, originating from the neural crest

169 hough Fgf10 RNA is expressed normally in the periocular mesenchyme, Ugdh mutation leads to excessive

170 t Npnt promotes pNC migration from explanted periocular mesenchyme, which requires Itgalpha8, focal a

171 t and the mesoderm-derived precursors of the periocular mesenchyme.

172 c cup, ventral coloboma, and a deficiency of periocular mesenchyme.

173 ions with specific environments and signals: periocular mesenchyme/BMP specifies pigmented epithelium

174 time to diagnosis of contralateral ocular or periocular metastasis was 94 months (median, 48 months;

175 37 degrees C; optimized intraperitoneal and periocular muscle cell transplantation; and epifluoresce

176 f Myf5, there is a clear distinction between periocular myogenic and non-myogenic cell lineages accor

177 tients (16 male) of median age 76 years with periocular (n=6) or orbital (n=15) BCC.

178 Periocular necrotizing fasciitis is a rare but potential

179 As seen in these 5 cases, periocular necrotizing fasciitis may cause severe visual

180 We report 5 cases of periocular necrotizing fasciitis resulting in severe vis

181 nfections such as cytomegalovirus infection, periocular nerve involvement due to leprosy, and hyperse

182 ious ocular tissues, including the migratory periocular neural crest (pNC), which also express the in

183 tingly, neuropilin-1 (Npn-1) is expressed by periocular neural crest but down-regulated, in a manner

184 Furthermore, Sema3A inhibits periocular neural crest migration in vitro.

185 le of Sema3A/Npn-1 signaling in coordinating periocular neural crest migration that is vital for prop

186 The recurrence rate of periocular nodular basal cell carcinoma (PNBCC) followin

187 ional case series, consecutive patients with periocular or orbital BCC who met criteria for treatment

188 Treatment for contralateral periocular (orbit or eyelid) metastasis was excision (n

189 oculo[dermal]) melanocytosis is a congenital periocular pigmentary condition that can lead to the dev

190 , or three injections (intravitreal [IVT] or periocular [PO]) of AdNull.11D (empty cassette) at 2-wee

191 e used at every surgical facility, including periocular povidone-iodine and intracameral moxifloxacin

192 ular transgene expression is associated with periocular pretreatment with corticosteroid.

193 the quality of care for patients undergoing periocular reconstruction.

194 the years, he underwent multiple ocular and periocular reconstructive surgeries.

195 expressing neural crest cells remain in the periocular region and contribute to the anterior uvea an

196 Cranial neural crest cells migrate into the periocular region and later contribute to various ocular

197 ing alcohol-free antiseptic solutions in the periocular region and taking measures to protect the dep

198 ld be used with caution, particularly in the periocular region because the late effects of hypofracti

199 Patients with a periocular region nonmelanoma skin cancer (NMSC) or a no

200 capillary hemangiomas can also arise in the periocular region of adults.

201 whereby neural crest cells aggregate in the periocular region prior to their migration and different

202 Squamous cell carcinoma affecting the periocular region represents a risk of solid organ trans

203 of the exenteration socket and contralateral periocular region was captured through noncontact facial

204 Despite their ability to migrate to the periocular region, neither cardiac nor trunk neural cres

205 nced techniques utilizing injectables in the periocular region.

206 and efficacious nonsurgical alternatives in periocular rejuvenation.

207 nced techniques using facial injectables for periocular rejuvenation.

208 ncluded if they utilized flap techniques for periocular repair, represented original peer-reviewed re

209 PST is the best periocular route for vitreous NaF delivery with minimal

210 c staining) was present in 29 of 35 cases of periocular SC (82.9%).

211 p16 overexpression is common in periocular SC but unrelated to HR-HPV status.

212 as an etiologic agent in the development of periocular SC using multiple modalities to maximize sens

213 Unstained paraffin sections of 35 cases of periocular SC were analyzed with immunohistochemistry fo

214 ation of p16 positivity is not applicable to periocular SC.

215 ation as adjuvant or neoadjuvant therapy for periocular SEB and SCC.

216 All 10 sporadic periocular sebaceous carcinomas maintained strong staini

217 riocular NMSCs, ophthalmologic findings, and periocular sequelae after the repair.

218 Periocular sequelae included lower eyelid ectropion (6 m

219 ts the prognosis of patients with eyelid and periocular SGC, which worsens with the advancing stage.

220 d stimulus (CS) that was paired with a brief periocular shock unconditioned stimulus (US).

221 The most common abnormalities were in the periocular skin and ocular surface, including interpalpe

222 ed with conjunctivitis, meibomitis, dry eye, periocular skin changes, and trichomegaly.

223 response, CD154(-/-) mice developed HSK and periocular skin disease with similar kinetics and severi

224 om ganglia to the cornea and failed to cause periocular skin disease, which requires zosteriform spre

225 (-/-) mice developed more severe corneal and periocular skin disease.

226 inished but was heaviest in mice with active periocular skin disease.

227 rowth in the cornea, trigeminal ganglia, and periocular skin following corneal infection compared to

228 Virus was present in the periocular skin from 24 h despite the lack of significan

229 d herpes stromal keratitis (HSK), as well as periocular skin lesions that are characterized by vesicl

230 l-depleted mice displayed moderate to severe periocular skin lesions, progressively became cachetic,

231 blepharitis and viral replication within the periocular skin of KOSV2-infected mice compared to mice

232 her than by direct spread from cornea to the periocular skin.

233 wth of mature, compact bone in the ocular or periocular soft tissue, and it is the rarest form of ocu

234 ornea can be described by a two-compartment (periocular space and cornea, with a dissolution step for

235 f the initial leak-back of the dose from the periocular space into the precorneal area.

236 on can be explained with a four-compartment (periocular space, choroid-containing transfer compartmen

237 compartment) model with elimination from the periocular space, retina, and choroid compartment.

238 parallel elimination from the cornea and the periocular space.

239 injected into the posterior subconjunctival (periocular) space in rats under anesthesia.

240 nges in the occurrence of various ocular and periocular specimens.

241 xture of 2 trial types: a tone paired with a periocular stimulation (A+) or a tone and light presente

242 and light presented simultaneously without a periocular stimulation (XA-).

243 citor, B) and retardation (X paired with the periocular stimulation) tests, the presence of inhibitio

244 Likewise, during reflexive blinks to periocular stimulation, IpN cells show excitation-suppre

245 slow to develop excitation when paired with periocular stimulation.

246 of metastasis to the contralateral ocular or periocular structures included the choroid in 4 patients

247 ting from UM to the contralateral ocular and periocular structures is rare and generally occurs in pa

248 M metastasis to the contralateral ocular and periocular structures were included.

249 c to the orbit and ocular adnexa (eyelid and periocular structures) has changed in recent decades.

250 neurotrophic keratitis without damaging the periocular structures.

251 ht-shielding effects on the superior half by periocular structures.

252 M metastasis to the contralateral ocular and periocular structures.

253 erienced by two-thirds of patients receiving periocular subcutaneous anesthesia.

254 logic level decreases pain perception during periocular, subcutaneous anesthesia.

255 el II evidence from 18 studies on the use of periocular, suprachoroidal, and intravitreal triamcinolo

256 no bottle tip contact against the ocular or periocular surface; and (3)number of eye drops dispensed

257 Periocular surgery was performed in 14 children, which i

258 before surgery to patients having bilateral, periocular surgery.

259 ctival tissue harvested from patients during periocular surgery.

260 as sub-Tenon's blocks and the emergence of a periocular "T-sign" ascertained and measured by ultrasou

261 Periocular TA injection markedly decreased the acute inf

262 findings demonstrate that viral infection of periocular tissue and subsequent disease development occ

263 Histological studies of periocular tissue preparations demonstrated the presence

264 by zosteriform spread from the cornea to the periocular tissue via the trigeminal ganglion rather tha

265 Replication in trigeminal ganglia and periocular tissue was promoted by US11, as was periocula

266 d to evaluate the effect of exoplants on the periocular tissue.

267 replication in eyes, trigeminal ganglia, and periocular tissue.

268 tivity was observed in trigeminal ganglia or periocular tissue.

269 uence show that these genes are expressed in periocular tissues and in a pattern conserved with other

270 trong betaGal activity was first detected in periocular tissues of E13.5 embryos, and restricted to c

271 on capture assay in developing maxillary and periocular tissues suggest that the DNA region near the

272 no histopathological damage to the retina or periocular tissues.

273 stemic infections but can infect the eye and periocular tissues.

274 length), and routes of administration (e.g., periocular transscleral, suprachoroidal, intravitreal) o

275 Periocular treatment with corticosteroids may enhance ad

276 mplant had effectiveness superior to that of periocular triamcinolone acetonide injection for these o

277 Pilomatrixoma is a rare periocular tumor with potential for malignant transforma

278 idence, treatment, and outcome of ocular and periocular tumors in patients with xeroderma pigmentosum

279 In contrast, periocular vaccination with gB2/gD2 in MF59 provided sig

280 s significantly reduced by therapeutic local periocular vaccination.

281 thogranuloma (25%), 8 adult-onset asthma and periocular xanthogranuloma (22%), 7 Langerhans cell hist

282 surgery for facial malignancies outside the periocular zone.