ライフサイエンスコーパス: peripheral organ

1 ration of viremia and viral dissemination to peripheral organs.

2 ese mice was markedly enhanced in thymus and peripheral organs.

3 he thymus and for Th2 differentiation in the peripheral organs.

4 ing but could not detect specific binding in peripheral organs.

5 In contrast, LVsp2 disseminated better to peripheral organs.

6 ent signals to circadian clocks in mammalian peripheral organs.

7 mmune response to intracellular infection in peripheral organs.

8 ells from other secondary lymphoid organs or peripheral organs.

9 ed by humoral and cellular autoreactivity to peripheral organs.

10 tics of (11)C-d-methamphetamine in brain and peripheral organs.

11 ole in the inhibition of T-cell responses in peripheral organs.

12 nstitutive IL-4 and IFN-gamma transcripts in peripheral organs.

13 -, L-selectin-) mediating immune response in peripheral organs.

14 rase (NADPH-d) histochemistry in the CNS and peripheral organs.

15 - animals lacked NKT cells in the thymus and peripheral organs.

16 her smokers would also have reduced MAO A in peripheral organs.

17 ) rhythms are expressed in a wide variety of peripheral organs.

18 cantly decreased in the neocortex but not in peripheral organs.

19 mokers would also have reduced MAO levels in peripheral organs.

20 alformations without overt histopathology of peripheral organs.

21 but substantial amounts are also present in peripheral organs.

22 the central nervous system and in most major peripheral organs.

23 d is also an important detoxifying enzyme in peripheral organs.

24 (-)B220(+) (double-negative [DN]) T cells in peripheral organs.

25 n rhythms of gene expression occur widely in peripheral organs.

26 pt upregulation of inflammatory mediators on peripheral organs.

27 ue features of CNS vasculature absent in the peripheral organs.

28 n composition of the brain or alterations in peripheral organs.

29 B7 suggests increased immunogenicity of the peripheral organs.

30 hypoxic and iron stress compared with other peripheral organs.

31 selected by self Ag/MHC and emigrate to the peripheral organs.

32 es develop within the thymus and emigrate to peripheral organs.

33 (SCN) synchronizes subsidiary clocks in most peripheral organs.

34 established in the kidney and possibly other peripheral organs.

35 logical changes in the respiratory tract and peripheral organs.

36 Cholinergic system deficits can involve also peripheral organs.

37 systems, including the spinal cord and other peripheral organs.

38 ction and the transport of dietary lipids to peripheral organs.

39 s in substantial undesirable transduction of peripheral organs.

40 and enhanced bacterial clearance in multiple peripheral organs.

41 g their trafficking from the blood stream to peripheral organs.

42 ngly, found to be expressed in the brain and peripheral organs.

43 eral immunity and increasing fungal loads in peripheral organs.

44 stablished to meet the functional demands of peripheral organs.

45 ass at a very early stage and disseminate to peripheral organs.

46 bstances from stimulated terminal endings in peripheral organs.

47 es and an impaired CD4(+) T cell response in peripheral organs.

48 trations and integrates sensory signals from peripheral organs.

49 oth in the central nervous system and in the peripheral organs.

50 te of PAS-mediated CSF redistribution toward peripheral organs.

51 standing of connectivity between the CNS and peripheral organs.

52 present in mammals in the brain and several peripheral organs.

53 ribution of (18)F-FHNP and (18)F-FES in most peripheral organs.

54 nantly in enterohepatic tissues, but also in peripheral organs.

55 y high levels of viremia and virus titers in peripheral organs.

56 gnificant increases in glucose metabolism in peripheral organs.

57 was high in brain with much lower levels in peripheral organs.

58 o dietary factors and metabolic signals from peripheral organs.

59 bone marrow (BM) before they migrate out to peripheral organs.

60 ecific epigenome plasticity in the brain and peripheral organs.

61 cetylcholinesterase density in the brain and peripheral organs.

62 grate toward infected cells after entry into peripheral organs.

63 Cat2 expression is not induced in MDSCs in peripheral organs.

64 or imaging acetylcholinesterase densities in peripheral organs.

65 l replication and associated pathogenesis in peripheral organs.

66 ial innervation and blood flow regulation in peripheral organs.

67 nificant effects on autonomic innervation in peripheral organs.

68 hough there was no dissemination of fungi to peripheral organs.

69 ut little effort has been devoted to imaging peripheral organs.

70 tres in the spleen and the spread of LCMV to peripheral organs.

71 prevents pathogenic herpesvirus infection in peripheral organs.

72 toxic T cell differentiation in lymphoid and peripheral organs.

73 effector-memory phenotype and enrichment in peripheral organs.

74 These findings indicate that central and peripheral organs accommodate selection and peripheral s

75 CD8 T cells persist at high frequencies in peripheral organs after resolution of an immune response

76 oughout the central nervous system (CNS) and peripheral organs, after intravenous administration of a

77 omplex array of metabolic signals, sensed by peripheral organs along with specific locations within t

78 ing involves changes in sterol metabolism in peripheral organs and also in the brain.

79 imilar to the mesothelial membrane lining of peripheral organs and body cavities, and it encases bloo

80 ng innate, adaptive, and structural cells in peripheral organs and bone marrow.

81 indotricarbocyanine iodide-labeled hADSCs in peripheral organs and brain after TBI.

82 Thus, HSPCs can survey peripheral organs and can foster the local production of

83 ssociated with greater virus accumulation in peripheral organs and central nervous system tissues.

84 ulation of memory T cells remains present in peripheral organs and contributes to the control of seco

85 r in the intestine, fail to export copper to peripheral organs and die a few weeks after birth.

86 enger RNA distribution were widespread among peripheral organs and in the CNS.

87 absence of detectable organic disease in the peripheral organs and may cause normal or physiologic co

88 r regulator of thermogenesis, acting both in peripheral organs and on central autonomic pathways.

89 ize the importance of its communication with peripheral organs and pave the way for a better understa

90 Myo-miRs are imported selectively to peripheral organs and preferentially to the BM.

91 splayed significantly reduced viral loads in peripheral organs and showed prolonged survival.

92 n (alpha-Syn) aggregation that originates in peripheral organs and spreads to the brain.

93 In peripheral organs and the brain, no difference in (11)C-

94 gy homeostasis and communication between the peripheral organs and the brain.

95 energy expenditure, integrating inputs from peripheral organs and the environment.

96 In mice, the mutant poorly disseminated to peripheral organs and the production of proinflammatory

97 sistency of oscillator properties in various peripheral organs and tissues from the period3-luciferas

98 y in the central nervous system, but also in peripheral organs and tissues.

99 unication link between our brain and several peripheral organs and tissues.

100 information between the nervous systems and peripheral organs and tissues; therefore, developing tre

101 mine and (-)-cocaine in the baboon brain and peripheral organs and to assess the saturability and pha

102 -fold higher in the brain than in any tested peripheral organs and was at its highest 24h following t

103 rtality by restricting virus accumulation in peripheral organs and, subsequently, in central nervous

104 ronic therapy for disorders of the brain and peripheral organs, and a tool to study the physiology of

105 survival, more rapid fungal clearance in key peripheral organs, and an altered inflammatory response.

106 Cytogenesis in adult peripheral organs, and in all organs during development,

107 mation, increased bacterial dissemination to peripheral organs, and increased host mortality.

108 aller amounts processed in kidneys and other peripheral organs, and only minimally in the liver.

109 Virus titers in serum, peripheral organs, and the brain were similar in V3000-

110 easured their localization in blood, various peripheral organs, and whole and capillary-depleted brai

111 astrocytes; however, analogous astroglia in peripheral organs are poorly understood.

112 The gonads and peripheral organs are targets of EDCs, and research from

113 ting hormones whose actions were confined to peripheral organs, are now known to be released in the b

114 As are endogenously present in rat brain and peripheral organs as determined via targeted lipidomics

115 in gamma delta T cell production extends to peripheral organs as IL-7 -/- mice are essentially devoi

116 Because smoking exposes peripheral organs as well as the brain to MAO A-inhibito

117 Because smoking exposes peripheral organs as well as the brain to MAO-inhibitory

118 ssive neurodegenerative disease that affects peripheral organs as well as the central nervous system

119 e in T cell infiltration and emigration from peripheral organs, as well as being specifically downreg

120 infection of lung tissue in BALB/c mice and peripheral organs at low doses.

121 ystem (CNS) and the autonomic innervation of peripheral organs bidirectionally.

122 e may occur through direct actions of GCs on peripheral organs, but could also be mediated by the hyp

123 educed tissue inclusion bodies in brain, and peripheral organs, but did not prolong lifespan in these

124 al disease with high viral multiplication in peripheral organs, but mu11E10 produced nonfatal infecti

125 LEI-515 increased 2-AG levels in peripheral organs, but not mouse brain.

126 bone marrow and complete their maturation in peripheral organs, but the molecular events controlling

127 ssion of circadian oscillations in different peripheral organs by diverse pathways.

128 genous cinnabarinic acid in brain tissue and peripheral organs by high-performance liquid chromatogra

129 f beta-galactosidase activity in the CNS and peripheral organs by intravenous gene therapy led to pro

130 decreases bacterial burden in the lungs and peripheral organs by potentiating C3 opsonization on bac

131 of systemic inflammation and sepsis involves peripheral organs, causing gastrointestinal, renal, and

132 stigated whether excitotoxicity may occur in peripheral organs, causing tissue injury, and report tha

133 To explore whether peripheral organ circadian clocks may affect the central

134 rresponding decrease in monocyte uptake into peripheral organs compared to nontransgenic littermates.

135 showed that V3043 replication was reduced in peripheral organs compared to that of V3000, titers in s

136 ice were found higher in the BM but lower in peripheral organs compared with control littermates, ind

137 system, but also has important roles in the peripheral organs controlling cellular metabolism.

138 In sensory systems, peripheral organs convey sensory inputs to relay network

139 t voxelwise clusters of TREM2 PET signals in peripheral organs correlated with TREM2 protein expressi

140 and more broadly emphasize the importance of peripheral organ damage as a possible mechanism that med

141 ct in NK cell numbers in the bone marrow and peripheral organs despite increased proliferation and in

142 These findings confirm that peripheral organs differ in their response to SCN-depend

143 id hormone-a regulator of metabolism in many peripheral organs-directly activates cell-type-specific

144 In most cases, peripheral organs display robust switches in tissue invo

145 tween postganglionic sympathetic neurons and peripheral organs distributed widely throughout the body

146 For peripheral organ distribution volume ratios, the descend

147 lrp2) are activated in a circadian manner in peripheral organs during 12 h dark:12 h dark (DD) but no

148 diating essential Notch signaling in several peripheral organs during pharmacological inhibition of P

149 lowing stroke with no effects of toxicity or peripheral organ dysfunction.

150 However, Long Covid can also affect other peripheral organs, especially the brain.

151 The 2 drugs showed similar behavior in all peripheral organs examined except the kidneys and pancre

152 target-mediated clearance or accumulation in peripheral organs except lung.

153 equency because of reduced glucose uptake in peripheral organs, excessive hepatic glucose production,

154 In addition, peripheral organs expressed tissue-specific differences

155 y scans showed radioactivity in brain and in peripheral organs expressing NOP receptors, such as hear

156 Activation of peripheral organs following explosive brain death may be

157 The olfactory epithelium (OE) is the peripheral organ for olfaction and is subject to acquire

158 HTT-targeted ASO (HTT ASO) to the brain and peripheral organs for HD.

159 y of mutant HTT lowering ASOs to the CNS and peripheral organs for HD.

160 entrations of five brain regions and of four peripheral organs from 5 months old, male and female, wi

161 exhibit diversity in studies of central and peripheral organ function and disease.

162 wild-type levels, and by 8 months of age all peripheral organs had accumulated sphingomyelin and demo

163 would parallel that of sexual behaviors and peripheral organs has so far uncovered modest quantitati

164 specifications of pericytes between CNS and peripheral organs have not been resolved at the genetic

165 In peripheral organs, immune complexes engage the complemen

166 delivering it from the hepatic stores to the peripheral organs in a complex with retinol (ROH) and tr

167 We measured MAO A in peripheral organs in a group of 9 smokers and compared i

168 we also detected a bioluminescence signal in peripheral organs in both conditions, confirmed by the p

169 itic cells or macrophages and recruitment to peripheral organs in chronic inflammatory diseases are d

170 estigate the feasibility of imaging MAO B in peripheral organs in humans with PET.

171 tobacco smoke exposure on MAO B activity in peripheral organs in humans.

172 e regarding the role of lipids in tissues of peripheral organs in mammals.

173 d an impaired transport of dietary lipids to peripheral organs in mice lacking DARS2 in intestinal ep

174 Here we compared MAO B in peripheral organs in nonsmokers and smokers by using pos

175 lts in a systemic increase of neutrophils in peripheral organs in the absence of histological inflamm

176 tial correction of NAGLU activity in several peripheral organs in the murine model of MPS IIIB.

177 mine and (11)C-(-)-cocaine in both brain and peripheral organs in the same animal.

178 of viral load in circulating blood cells and peripheral organs in the two groups, WNV-infected polymo

179 neurons, brain, skeletal muscle and multiple peripheral organs in treated patients.

180 atively at P15 in sympathetically innervated peripheral organs, in sympathetic ganglia, in adrenal gl

181 n neurons and nonneuronal cells in brain and peripheral organs including sperm, eggs, and preimplanta

182 ible for generating the circadian rhythms in peripheral organs including the lung.

183 age [CFU-GEMM]) from the bone marrow (BM) to peripheral organs, including blood, and also increases t

184 of prion protein amyloid was seen throughout peripheral organs, including the bowel and peripheral ne

185 prepared from the central nervous system and peripheral organs, including the buccal muscles, esophag

186 pheral beta-adrenergic receptor signaling in peripheral organs, including the gastrointestinal tract.

187 to amylin accumulation and proteotoxicity in peripheral organs, including the heart.

188 Peripheral organs, including the kidney, are the site of

189 or imaging acetylcholinesterase densities in peripheral organs, including the salivary glands, heart,

190 ly harmful stimulation of estrogen-sensitive peripheral organs, including the uterus and the anterior

191 were also observed in another mouse model of peripheral organ inflammation (i.e., 2,4-dinitrobenzene

192 ur observations provide a clear link between peripheral organ inflammation and cerebral changes that

193 rain communication pathway in the setting of peripheral organ inflammation whereby monocytes are recr

194 central neurotransmission, the link between peripheral organ inflammation, circulating cytokine sign

195 inflammatory response in hippocampus during peripheral organ inflammation.

196 The reproductive tract tissues and peripheral organs integrated into a microfluidic platfor

197 The altered trafficking of NK cells from peripheral organs into the blood was due to selective hy

198 as significant effects on the function(s) of peripheral organs involved in maintaining body compositi

199 er, whether BDNF exerts metabolic effects on peripheral organs is currently unknown.

200 Arterial blood transport into peripheral organs is indispensable for developmental gro

201 e the peptide repertoire in both central and peripheral organs is nearly the same, interactions of th

202 The repertoire of T lymphocytes available in peripheral organs is tuned in the thymus.

203 ety of harmful lipids in the heart and other peripheral organs, known as lipotoxicity.

204 lishment of the vascular-immune interface in peripheral organs, lastly contributing to CD8(+) tissue

205 (~43%) without any demonstrable toxicity to peripheral organs (liver, kidney).

206 ly labeled BMSCs traveled to and remained in peripheral organs (lungs, spleen, liver) 3 days after IV

207 el through the blood and replace cDCs in the peripheral organs, maintaining homeostasis of the highly

208 asing patient lifespan, impaired function of peripheral organs may develop into significant future co

209 ite stable donor blood pressure, ischemia of peripheral organs may explain in part the increased inci

210 oadly, our results suggest that signals from peripheral organs may serve as an important component of

211 devices suitable for probing both brain and peripheral organ neurophysiology during behavior.

212 pling the spread of the double mutant to the peripheral organs of animals and by inducing cytokine/ch

213 NOS in sensory areas both in the CNS and the peripheral organs of Aplysia and implies a role for NO a

214 ies demonstrate that neutrophils increase in peripheral organs of B7-H4KO mice more so than their lit

215 Tissue-specific expression in brain and peripheral organs of different exogenous genes (beta-gal

216 nction and the critical coupling of brain to peripheral organs of hearing in the dementias.

217 lar to that in the brain was observed in the peripheral organs of LCMV-infected mice.

218 sibly disappear from the spleens, blood, and peripheral organs of mice early after infection with Lis

219 essment of TREM2 expression in the brain and peripheral organs of mice.

220 KT2, and NKT17 sublineages in the thymus and peripheral organs of naive mice.

221 eyes and olfactory terminals, as well as in peripheral organs of Parkinsonian patients.

222 serotonin (5-HT)-immunoreactive elements in peripheral organs of the sea-slugs Pleurobranchaea calif

223 he vagus nerve and was not observed in other peripheral organs or in brain regions that control feedi

224 smokers have significantly reduced MAO B in peripheral organs, particularly in the heart, lungs, and

225 Brain-first cases displayed minimal peripheral organ pathology in prediagnostic phases, cont

226 FN4-expressing cells from the bone marrow to peripheral organs predicts preneoplastic changes in the

227 In C. elegans mechanisms by which peripheral organs relay internal state information to th

228 tributing effects of low SMN in one relevant peripheral organ - skeletal muscle - by selectively depl

229 ariety of proteins, including those that are peripheral organ-specific and are not expressed by other

230 so rhythmic expression of these genes in all peripheral organs studied.

231 TCF7L2 is important in the development of peripheral organs such as adipocytes, pancreas, and the

232 ators of lipid-induced insulin resistance in peripheral organs such as muscle.

233 Extramedullary myelopoiesis occurs in peripheral organs such as spleen and produces many types

234 rain regions related to thermoregulation and peripheral organs such as spleen, liver, and blood showe

235 of lung involvement (L), and malfunction of peripheral organs such as the kidney, liver, and brain (

236 daily cellular metabolic cycles, imposing on peripheral organs such as the liver a strict programme t

237 cells are found in the thymus as well as in peripheral organs such as the liver, spleen, and bone ma

238 dies have examined the effect of morphine on peripheral organs, such as the heart, in morphine-tolera

239 in the brain is set by light, pacemakers in peripheral organs, such as the liver, are reset by food

240 lized time keepers in the brain, but also in peripheral organs, suggesting that the ability to keep t

241 In several peripheral organ systems, including lung and gut, we obs

242 nervous system; however, stroke also impacts peripheral organ systems.

243 n mediating sympathetic neurotransmission in peripheral organ systems; however, central alpha1ARs are

244 In peripheral organs, T cell-specific ablation of Vps34 had

245 -induced functional impairments in the major peripheral organs that control energy flux: adipose tiss

246 in modulating the host antiviral response in peripheral organs that controls bunyavirus neuroinvasion

247 In contrast to vessels of peripheral organs, the BBB limits the exchange of inflam

248 Like other peripheral organs, the cochlea is subjected to environme

249 the vector and damages local tissue in many peripheral organs, the immune response to adenovirus in

250 ne intestines without effecting migration to peripheral organs; this suggests that alpha4beta7-select

251 (zeitgebers) for the circadian clock within peripheral organs through the activation of tissue-speci

252 CSF efflux toward peripheral organs through the PAS pathway represents a m

253 tory mediators and cell surface molecules in peripheral organs to be engrafted, making them more pron

254 previously under-recognized contribution of peripheral organs to brain dysfunction and damage.

255 o raised the question of the contribution of peripheral organs to brain function and plasticity at a

256 anticipated cross-talk between the liver and peripheral organs to influence insulin sensitivity, prob

257 ability as they move from the bone marrow to peripheral organs to mediate their effector functions.

258 by adipose tissue and acts in the brain and peripheral organs to regulate glucose and lipid metaboli

259 research reveals that neurons interact with peripheral organs to regulate metabolism and longevity b

260 The sympathetic nervous system innervates peripheral organs to regulate their function and maintai

261 y by transferring antigenic information from peripheral organs to T cells in lymph nodes (LNs).

262 des a major communication pathway from vital peripheral organs to the brain, can have significant pot

263 esponsible for transmitting information from peripheral organs to the brain, is the primary neural in

264 central integrator of metabolic signals from peripheral organs to the brain, which would represent a

265 ain, touch, itch and body part movement from peripheral organs to the central nervous system(1,2).

266 hypothesis that the flow of sterol from the peripheral organs to the liver is dependent upon circula

267 the centripetal flux of cholesterol from the peripheral organs to the liver was essentially constant

268 higher titers than the sigma1s-null virus in peripheral organs to which reovirus spreads via the bloo

269 re able to rapidly eradicate Vacc-IND-G from peripheral organs, to mediate delayed-type hypersensitiv

270 nriched AAV capsids that may inform vectors' peripheral organ tropism and side effects.

271 brain death is a significant risk factor for peripheral organs used for transplantation.

272 and 180 days as well as any accumulation in peripheral organs using an animal model.

273 Pres accumulation in the spleen and in other peripheral organs was first monitored to describe the ea

274 e of myogenic vasoconstriction, perfusion of peripheral organs was increased, systemic vascular resis

275 Furthermore, viral dissemination to peripheral organs was not observed in these mice.

276 e cell-based formulations in mouse brain and peripheral organs was observed.

277 his central catastrophe and its influence on peripheral organs, we have established a reproduceable m

278 bacteria loads in the intestinal mucosa and peripheral organs were elevated in Lpa1(-/-) mice.

279 ayed dissemination of bacteria from lungs to peripheral organs were observed in BKO mice.

280 vels were attenuated, and retinoid levels in peripheral organs were perturbed.

281 Peripheral organs were unaffected in Oga (DeltaBr) mice,

282 -derived dendritic cell (DC) precursors seed peripheral organs, where they encounter diverse cellular

283 BM, enter the blood, and traffic to multiple peripheral organs, where they reside for at least 36 hr

284 dritic cell-derived IFN-I primarily protects peripheral organs, whereas concomitant TLR and RLH signa

285 suppressed T-cell development in thymus and peripheral organs, whereas deletion of Rac1 moderately a

286 s on average 17-fold higher in brain than in peripheral organs, whereas JNK protein levels were simil

287 ction, NF1 selectively disseminated to mouse peripheral organs, whereas the other strains (NF2, NF3,

288 s the master circadian pacemaker, entraining peripheral organs which also demonstrate circadian rhyth

289 e was associated with increased infection in peripheral organs, which resulted in higher virus titers

290 nt and gives rise to a severe lymphopenia in peripheral organs, while also leading to pro-B cell line

291 noninvasively modulating neural signaling in peripheral organs will advance the study of nerves and t

292 ortex and hippocampus) and kidney tissues, a peripheral organ with documented age-related dysfunction

293 m 60 to 120 min after injection in brain and peripheral organs with high TSPO densities such as lung

294 ding (dissociation constant, 6-39 nM) in pig peripheral organs with low nonspecific signal.

295 on of T cells and defective early seeding of peripheral organs with regulatory T cells (Tregs).

296 tissue lymphatic vasculature that exists in peripheral organs with the proposed function of meningea

297 s with SIVE had more infected macrophages in peripheral organs, with the exception of lymph nodes.

298 dicated that infused MSCs distributed within peripheral organs without homing to the brain.

299 impracticality of studying cells residing in peripheral organs without performing invasive biopsies,

300 hologic amyloid accumulates in the CNS or in peripheral organs, yet the mechanism underlying the targ