ライフサイエンスコーパス: peripherin

1 holine, calcitonin gene-related peptide, and peripherin).

2 ronal type III intermediate filament protein peripherin.

3 ly labeled to detect alpha9, calretinin, and peripherin.

4 TrkC, and RET and the sensory neurofilament peripherin.

5 on endings, are not labeled by calretinin or peripherin.

6 t contain the alpha9 nAChR but did stain for peripherin.

7 tein (GFAP); and the nerve structural marker peripherin.

8 in NOD mice recognizing the neuronal antigen peripherin.

9 the absence of the outer segment protein rds/peripherin.

10 2 protein is 54%, identical to mammalian rds/peripherin.

11 , and a reduction in the level of normal rds/peripherin.

12 ucine (P216L) amino acid substitution in rds/peripherin.

13 nied by gain of the tetraspanin rim protein, peripherin.

14 photoreceptor ciliary transmembrane protein, Peripherin.

15 export and translation, but had no effect on peripherin.

16 trafficking of OS membrane proteins such as peripherin 2 (PRPH2) and rhodopsin.

17 g for splice site mutation c.828+3A>T in the peripherin 2 (PRPH2) gene should be a high priority in f

18 Mutations in peripherin 2 (PRPH2) have been associated with retinitis

19 Peripherin 2 (Prph2) is a photoreceptor tetraspanin, and

20 Peripherin 2 (PRPH2) is a retina-specific tetraspanin pr

21 alfunctions of the LE.SIGNIFICANCE STATEMENT Peripherin 2 (PRPH2) is a tetraspanin protein abundantly

22 Peripherin 2 (PRPH2) is a tetraspanin protein concentrat

23 The retinal disease gene peripherin 2 (PRPH2) is essential for the formation of p

24 Mutations in peripherin 2 (PRPH2), also known as retinal degeneration

25 pigmentosa, lacks a functional gene encoding peripherin 2.

26 Peripherin-2 (also known as peripherin/rds), a photorece

27 hotoreceptor-specific membrane glycoprotein, peripherin-2 (also known as peripherin/rds), which is in

28 Mutations in the photoreceptor-specific gene peripherin-2 (PRPH-2, also known as retinal degeneration

29 ypeptide comprising the C-terminus of bovine peripherin-2 (R284-G346) binds to the membrane mimetic,

30 ation of EGFP-PDE6C with the disc rim marker peripherin-2 and endogenous frog PDE6.

31 of intracellular membrane fusion induced by peripherin-2 and the mechanism of enveloped viral fusion

32 Previously published data showed that both peripherin-2 and viral fusion proteins are transmembrane

33 lular retinal rod outer segment disk protein peripherin-2 binds to membranes, adopts a helical confor

34 Furthermore, the fusion-active sequence of peripherin-2 exhibits a sequence motif that matches the

35 In this study, we show that peripherin-2 forms a complex with melanoregulin (MREG),

36 that this newly identified protein regulates peripherin-2 function.

37 MREG colocalized with peripherin-2 in WT (CB6F1/J) and in rds+/- retinas.

38 the C terminus of human, bovine, and murine peripherin-2 is an amphiphilic fusion peptide domain (re

39 s et al. show that peripherin (also known as peripherin-2 or peripherin-2/rds) diverts membrane traff

40 ereby normal rods express a modest excess of peripherin-2 over the amount required for complete disc

41 Peripherin-2 protein was produced in yeast and analyzed

42 the structure of the transmembrane domain of peripherin-2 was constructed.

43 e, P296T, P296A, P296L, and P296E mutants of peripherin-2 were expressed as His6-tagged full-length p

44 nts or contain the associated markers ROM-1, peripherin-2, and RP1.

45 Peripherin-2, the product of the rds gene, is a tetraspa

46 owed formation of a complex between MREG and peripherin-2-ROM-1 hetero-oligomers.

47 in, peripherin/rds, rds/peripherin, rds, and peripherin-2.) Peripherin/rds appears to act as a struct

48 that the photoreceptor-specific tetraspanin, peripherin-2/rds (P/rds), may contribute to the highly c

49 By contrast, anti-peripherin-2/rds antibody, Xper5A11, labeled the closed

50 significantly strengthens the evidence that peripherin-2/rds functions directly to shape the high-cu

51 Peripherin-2/rds is required for biogenesis of vertebrat

52 at peripherin (also known as peripherin-2 or peripherin-2/rds) diverts membrane traffic to photorecep

53 gests that within the context of full-length peripherin-2/rds, partitioning would most likely occur a

54 ations in the photoreceptor tetraspanin gene peripherin-2/retinal degeneration slow (PRPH2/RDS) cause

55 tnatal and adult mice, via immunostaining of peripherin (a marker of thinly myelinated and unmyelinat

56 Peripherin, a neuronal intermediate filament protein imp

57 Peripherin also coassembles into a single network of fil

58 Salinas et al. show that peripherin (also known as peripherin-2 or peripherin-2/r

59 mediate filament proteins (alpha-internexin, peripherin) also accumulated in these spheroids.

60 e absence of retinal degeneration slow (RDS)/peripherin, an essential outer segment structural protei

61 al degeneration slow or rds gene encodes rds/peripherin, an integral membrane glycoprotein in the out

62 are the result of regulatory changes to the peripherin ancestral gene along each lineage.

63 In contrast, the IFs peripherin and alpha-internexin are preferentially local

64 Recent studies have identified peripherin and ATF-3 molecules as crucial for neurite ou

65 Since peripherin and BPAG1-n also display similar expression p

66 as been found that peripherin-siRNA depletes peripherin and inhibits the initiation, extension, and m

67 5.6 mum(2)) and predominantly colabeled with peripherin and isolectin B4 markers of unmyelinated C-fi

68 Peripherin and its homologue ROM1 are retina-specific me

69 nt (nIF) protein family, which also includes peripherin and neurofilament (NF) triplet proteins.

70 was similarly involved in the degradation of peripherin and neurofilament IF proteins in neurons.

71 fected into vimentin(+) SW13 cells, and with peripherin and neurofilament proteins when transfected i

72 neurons, endogenous Nes-S co-assembles with peripherin and neurofilament proteins.

73 mers, have supported a widely held view that peripherin and neurofilament triplets form separate fila

74 The relative proportions of peripherin and NF-M increased above normal, whereas prop

75 The increases in peripherin and NF-M mRNAs were accompanied by increases

76 in both S and L/M cones, but S cones express peripherin and opsin 1 to 3 weeks before neighboring L/M

77 Peripherin and ROM1 interact in vivo and are predicted t

78 200 kDa neurofilament (NF-H) epitopes, NPY, peripherin and synapsin I, but not to hypophosphorylated

79 These data show that peripherin and the neurofilament proteins are functional

80 After crush, peripherin and ubiquitin levels remained also significan

81 uron-specific intermediate filament protein, peripherin, and by RA-stimulated extension of neuritic p

82 positive for 200 kDa neurofilament subunit, peripherin, and carbonic anhydrase.

83 to induce the expression of sodium channels, peripherin, and Thy-1 in PC12 cells because all three of

84 lectively increased transport of beta-actin, peripherin, and vimentin mRNAs from the cell body into t

85 adult calvaria, the highest concentration of peripherin- and CGRP-labeled fibers was found in sutures

86 he RNA for which binds hnRNP K, with that of peripherin, another intermediate filament protein, the R

87 Neurofilaments and peripherin appear to play some part in motor neuron dege

88 Peripherin appears concomitantly with opsin in both S an

89 d the classification of XIF3, plasticin, and peripherin as orthologs (products of the same genetic lo

90 Transgenic peripherin autoreactive B-lymphocytes infiltrate NOD pan

91 The unmyelinated innervation had detectable peripherin but not 160 kDa or 200 kDa neurofilament subu

92 ssed in many neurons that contain endogenous peripherin but was activated after injury.

93 n of mouse BPAG1 interacts specifically with peripherin, but in contrast to a previous study, mouse B

94 Peripherin, but not ROM1, is glycosylated and we examine

95 Over 100 pathogenic mutations in peripherin cause inherited rod- and cone-related dystrop

96 Canine RDS/peripherin cDNA was cloned and sequenced after reverse-t

97 ly deleting NFL in mice dramatically reduces peripherin content in sciatic axons.

98 ee of GFP expression by neurofilament(+) and peripherin(+) DRG neurons was similar.

99 in-like growth factor II, guanine deaminase, peripherin, early growth response 1, soluble guanylate c

100 Only neurons without peripherin epitopes, putative type I neurons, showed syn

101 Peripherin exhibits a distribution pattern identical to

102 proteins/protein complexes in extracts from peripherin-expressing and nonexpressing tissues.

103 GDNF promoted the development of peripherin-expressing neurons (E12 >> E14-16) and expres

104 ed synergistic survival effects; survival of peripherin-expressing neurons was purely additive.

105 Dramatic increases in peripherin expression have been shown to coincide with t

106 e element (centered at -173), which prevents peripherin expression in undifferentiated PC12 cells, an

107 in other successfully regenerating systems, peripherin expression increased rapidly after injury and

108 ctive and that neuron-specific regulation of peripherin expression may be due to interaction with dis

109 The canine RDS/peripherin gene (CFRDSP) has been excluded as a candidat

110 Thus, accurate cell type-specific peripherin gene expression in the PNS depends on element

111 king region, are required for activating the peripherin gene in response to nerve injury.

112 and revealed a missense mutation in the RDS/peripherin gene leading to a Tyr141Cys substitution.

113 PMSG was applied to the RDS/peripherin gene of 16 individuals from a family exhibiti

114 mutant peripherin transgene under control of peripherin gene regulatory sequences.

115 The peripherin gene, encoding a neuron-specific intermediate

116 (rds) mice which carry a mutation in the rds/peripherin gene.

117 e identified two regulatory sequences of the peripherin gene: a proximal negative element (centered a

118 pecific or injury-specific expression of the peripherin gene; however, the remaining intron, intron 1

119 th RP in humans, such as RHO, PDE6B, and RDS/peripherin, have been excluded.

120 esults of these experiments demonstrate that peripherin IF are critical determinants of the overall s

121 re organism in vivo, we disrupted endogenous peripherin IF in small-sized dorsal root ganglion (DRG)

122 in (10(-4) M) had no effect on the length of peripherin-immunoreactive olfactory fibers or LHRH cell

123 60 to -2308) necessary for full induction of peripherin in differentiated PC12 cells.

124 S and is activated after nerve injury is the peripherin intermediate filament gene, but little is kno

125 vo by studying the synthesis and assembly of peripherin intermediate filaments (IFs).

126 ather than forming an independent structure, peripherin is a subunit of neurofilaments in the adult P

127 Peripherin is a type III intermediate filament (IF) prot

128 system, a fifth neuronal IF protein known as peripherin is also present.

129 , despite a postnatal decline in expression, peripherin is as abundant as the triplet in the adult PN

130 Peripherin is cotranslationally assembled into insoluble

131 on of the intermediate filament (IF) protein peripherin is initiated during development at the time o

132 This new function of peripherin is performed independently from its well-esta

133 In dt mice, peripherin is present in axonal swellings of degeneratin

134 terns in the nervous system, we suggest that peripherin is the specific interaction partner of BPAG1-

135 ith markers of primary afferent nociceptors, peripherin, isolectin B4, and substance P, and markers o

136 Peripherin labeling of outer segments was nonuniform, an

137 Peripherin labels bouton-only afferents.

138 iption of these molecules and that a greater peripherin mRNA expression in injured cutaneous neurons

139 The results show that peripherin mRNA-containing particles (messenger ribonucl

140 Many peripherin mRNPs contain multiple mRNAs, possibly amplif

141 ults show that the motility and targeting of peripherin mRNPs, their translational control, and the a

142 nsgenic mice heterozygous for a specific rds/peripherin mutation (P216L) have lower DHA levels in the

143 (+/-) mutations, and mice with the P216L rds/peripherin mutation on the rds(+/-) background were main

144 Mice heterozygous for the spontaneous rds/peripherin mutation or mice carrying the P216L mutation

145 Moreover, peripherin mutations has been shown to disrupt the neuro

146 inent p62-immunoreactive, alphaS-, NFL-, and peripherin-negative inclusions.

147 n diseases, both large SMI-32(+) neurons and peripherin(+) neurons are selectively damaged by prolong

148 ed index of the motor neuron population) and peripherin(+) neurons share with large SMI-32(+) neurons

149 ity is provided by the observation that most peripherin(+) neurons, like large SMI-32(+) neurons, are

150 neurites, which have NFs made exclusively of peripherin, NFs were unaffected, but in the shaft of old

151 GP 9.5) as well as more specialized markers (peripherin, nNOS) in ES-NS, both at the transcriptional

152 cone opsin and either a structural protein (peripherin) or a phototransduction cascade protein (alph

153 The expression of a peripherin ortholog in Xenopus glia may represent either

154 eripherin/rds is also known as photoreceptor peripherin, peripherin/rds, rds/peripherin, rds, and per

155 ells showed the presence of neuronal markers peripherin, PGP9.5, HuD, tau, synaptic marker synaptophy

156 ), glutathione S-transferase mu2, cyclin D2, peripherin, plasma glutathione peroxidase, methyl CpG-bi

157 evelopment and regeneration, suggesting that peripherin plays an important role in axon formation.

158 Most of these neurons are peripherin positive and produce C fibers, although a sma

159 sed numbers of presumptive nociceptor axons (peripherin-positive axons containing calcitonin gene-rel

160 The numbers of peripherin-positive fibres also increased in the mucosal

161 Thus, XIF3, plasticin, and peripherin probably should be referred to as Xenopus, fi

162 bit accumulation of neurofilament (NF-L) and peripherin (PRPH) protein and formation of PRPH aggregat

163 the NOD mouse model to the neuronal protein peripherin (PRPH), a target Ag of islet-infiltrating B c

164 encoding the type III intermediate filament peripherin (Prph).

165 RDS encodes rds/peripherin (rds), a 36-kDa glycoprotein in the rims of r

166 The rds gene encodes rds/peripherin (rds), a membrane glycoprotein in the rims of

167 hotoreceptor peripherin, peripherin/rds, rds/peripherin, rds, and peripherin-2.) Peripherin/rds appea

168 t disk membrane proteins, such as rhodopsin, Peripherin-rds, Rom-1, and Abca4, but significantly disr

169 transgenic line expressing the normal mouse peripherin/Rds (NMP) was crossed with a higher-expresser

170 a transgenic mouse line expressing wild-type peripherin/rds (NMP), the authors evaluated the critical

171 Peripherin/rds (P/rds) is a disk rim protein that assemb

172 Peripherin/rds (P/rds) is a membrane glycoprotein essent

173 st membrane renewal, for which rhodopsin and peripherin/rds (P/rds) play critical roles.

174 ontribute to OS organization in concert with peripherin/rds (P/rds), a retinal tetraspanin.

175 Peripherin/rds (p/rds), an integral membrane protein fro

176 The gene product, peripherin/rds (P/rds), is a member of the tetraspanin p

177 Peripherin/rds (P/rds), the product of the retinal degen

178 enes analyzed, including rhodopsin (RP4) and peripherin/RDS (RP7), for the four adRP loci RP1, RP9, R

179 5' and 3' untranslated regions of the skate peripherin/rds (srds) cDNA were isolated by the rapid am

180 d caveolin; surprisingly, the fusion protein peripherin/rds (where rds is retinal degeneration slow),

181 C-terminally truncated peripherin/rds (Xper38)-GFP chimeric protein sorting was

182 SRDS protein is 54.5% identical with peripherin/rds across species.

183 ion of nearly 2 mol of phosphate per mole of peripherin/rds and a concomitant shift in the isoelectri

184 rbation are produced by inherited defects in peripherin/rds and contribute to the observed heterogene

185 The proteins peripherin/rds and rom-1 form a protein complex in the r

186 Peripherin/rds and rom-1 have structural roles in morpho

187 Peripherin/rds and rom-1 localized to this ciliary membr

188 Peripherin/rds and rom-1 trafficking is maintained in rh

189 Peripherin/rds and rom-1 trafficking were studied in sev

190 outer segment formation and distribution of peripherin/rds and rom-1 were examined by immunohistoche

191 Peripherin/RDS and ROM-1, two structural proteins that c

192 that likely reflects the tight regulation of peripherin/rds and the need for two functional alleles t

193 rds, rds/peripherin, rds, and peripherin-2.) Peripherin/rds appears to act as a structural element in

194 ations in the photoreceptor-specific protein peripherin/rds are associated with multiple retinal dise

195 s of the photoreceptor disc membrane protein peripherin/rds by analysis of the homologue in a primiti

196 Overexpression of peripherin/rds caused no detectable adverse effects on r

197 inal cDNA library was screened using a mouse peripherin/rds clone.

198 Uptake of rhodopsin and peripherin/rds coincided with the overgrowth of the evag

199 from samples prepared in the dark (13%), but peripherin/rds could not be detected in either preparati

200 n finds its way into the plasma membrane but peripherin/rds does not, remaining behind in vesicles.

201 A positive correlation was observed between peripherin/rds expression levels and the structural and

202 ogenetic analysis places SRDS at the base of peripherin/rds family and near the division of that grou

203 ic procedures for the purification of native peripherin/rds from bovine photoreceptor cell outer segm

204 Analysis of homogeneous peripherin/rds from the second procedure showed that exp

205 The GFP-peripherin/rds fusion proteins did not immunoprecipitate

206 Presence of GFP-peripherin/rds fusions correlated with disrupted incisur

207 maintenance of disk membrane structure, with peripherin/rds gene mutations resulting in photoreceptor

208 Heterozygotes with these different peripherin/RDS gene mutations showed variation in clinic

209 The coding regions of the peripherin/RDS gene were sequenced in each patient.

210 neration were found to have mutations in the peripherin/RDS gene.

211 t distinct loci, including the rhodopsin and peripherin/RDS genes as well as unidentified genes on ch

212 represents the skate orthologue of mammalian peripherin/rds genes.

213 ause of a null mutation in the gene encoding peripherin/rds has been thought to be the primary defect

214 photoreceptor cell's plasma membrane, while peripherin/rds immunolabeling occurs within cytoplasmic

215 These results demonstrate the necessity for peripherin/rds in ROS membrane fusion, specifically the

216 describes novel roles for the C terminus of peripherin/rds in targeting and maintaining ROS structur

217 ed us to characterize the functional role of peripherin/rds in the maintenance of rod outer segment (

218 ion, we found that recombination of purified peripherin/rds into lipid vesicles increased membrane fu

219 (Peripherin/rds is also known as photoreceptor peripherin

220 Peripherin/rds is an integral membrane protein required

221 ntegrity of the second intradiscal domain of peripherin/RDS is critical for normal macular cone struc

222 ly, both insert into the plasma membrane but peripherin/rds is recycled into cytoplasmic vesicles.

223 Total peripherin/rds levels in the retina were modulated by cr

224 A GFP fusion containing residues 317-336 of peripherin/rds localized uniformly to disk membranes.

225 uter segment supports previous evidence that peripherin/rds mice form homotetramers for outer segment

226 l coherence tomography in four patients with peripherin/RDS mutations and 27 age-similar healthy subj

227 peripherin/RDS mutations produced diffuse AF abnormaliti

228 this study suggest that human patients with peripherin/rds mutations, or other mutations that result

229 hors evaluated the critical in vivo level of peripherin/rds needed to maintain photoreceptor structur

230 sion proteins did not immunoprecipitate with peripherin/rds or rom-1, suggesting this region does not

231 RG function and assessed the consequences of peripherin/rds overexpression in both rods and cones by

232 a series of overlapping synthetic C-terminal peripherin/rds peptides to mediate model membrane fusion

233 Peripherin/rds plays an essential role in the maintenanc

234 Peripherin/rds plays an essential role in the morphogene

235 Peripherin/rds protein levels in NMP homozygotes were ap

236 which dictates well-regulated expression of peripherin/rds protein levels.

237 rated appropriate localization of transgenic peripherin/rds protein to the disc rim region of photore

238 In conclusion, studies with purified peripherin/rds reveal that the protein undergoes light-d

239 id not prevent the entrance of rhodopsin and peripherin/rds to the membrane evaginations believed to

240 Peripherin/rds transport and localization are polarized

241 During one procedure, peripherin/rds was copurified in association with rom-1

242 In developing wild-type photoreceptors, peripherin/rds was detected exclusively in the distal ti

243 A new homologue of peripherin/rds was identified from the skate retinal cDN

244 reorganization of disk membranes, opsin and peripherin/rds were fused to a fluorescent protein, Dend

245 Heterozygous mutations in peripherin/RDS were predicted to affect protein structur

246 s injected subretinally, for transduction of peripherin/rds(+/)(-) transgenic mice that carry the P21

247 Peripherin-2 (also known as peripherin/rds), a photoreceptor specific tetraspanin pr

248 ne glycoprotein, peripherin-2 (also known as peripherin/rds), which is inserted into the rims of phot

249 nd cone-specific proteins such as phosducin, peripherin/rds, and ROM1.

250 Rhodopsin, peripherin/RDS, and TIMP3 genes were screened for mutati

251 ted in the coding sequence of the rhodopsin, peripherin/RDS, and TIMP3 genes.

252 f degeneration, rod and cone opsins, but not peripherin/RDS, exhibited prominent ectopic localization

253 orphogenesis is reliant upon the presence of peripherin/rds, hereafter termed Rds.

254 ecific integral membrane proteins, opsin and peripherin/rds, in rod photoreceptors.

255 s is also known as photoreceptor peripherin, peripherin/rds, rds/peripherin, rds, and peripherin-2.)

256 nsgenic protein in the presence of wild-type peripherin/rds, using the monoclonal antibody 3B6.

257 ations regarding therapeutic intervention in peripherin/rds-associated retinal diseases.

258 g is cargo-specific and was not observed for peripherin/rds-Dendra2.

259 protein, that may play a regulatory role in peripherin/rds-dependent fusion.

260 sma membrane (R18-PM) with disk membranes or peripherin/rds-enriched large unilammellar vesicles (LUV

261 transgenic Xenopus, a C-terminally truncated peripherin/rds-GFP fusion predominantly localized to its

262 The presence of truncated peripherin/rds-GFP in the outer segment supports previou

263 al and functional rescue in animal models of peripherin/rds-induced retinal degeneration have not bee

264 ethods in wild-type, rhodopsin-knockout, and peripherin/rds-knockout mice.

265 ot been fully characterized, the presence of peripherin/rds-positive vesicles adjacent to the striate

266 the NMP protein when compared with wild-type peripherin/rds.

267 oteins for other proteins that interact with peripherin/rds.

268 es (LUVs) is inhibited upon trypsinolysis of peripherin/rds.

269 re rapid fusion detected with phosphorylated peripherin/rds.

270 effect on the traffic of rhodopsin, Rom1 or peripherin/rds; however, the retinal guanylate cyclases

271 Together, this study presents a new model of peripherin-reactive B lymphocyte-dependent autoimmune ne

272 molecules from the intra-islet-derived anti-peripherin-reactive hybridoma H280.

273 es, and mammals (called XIF3, plasticin, and peripherin, respectively) that are classified as type II

274 referred to as Xenopus, fish, and mammalian peripherin, respectively.

275 Peripherin/retinal degeneration slow (rds) and rom-1 are

276 ophoresis, we confirmed that the core native peripherin-ROM1 complex exists as a tetramer.

277 d methodology for high yield purification of peripherin-ROM1 from bovine retinas that permitted its b

278 Finally, we demonstrated that peripherin-ROM1 tetramers induce membrane curvature when

279 candidate RP genes, including rhodopsin, RDS/peripherin, RP2, and RPGR, were also examined in this pr

280 function is fulfilled by a separate part of peripherin's molecule.

281 In this study, it has been found that peripherin-siRNA depletes peripherin and inhibits the in

282 RDS/peripherin-specific restriction fragment length polymorp

283 Peripherin staining was irregular and disorganized.

284 olecular-mass neurofilament subunit (NFL) or peripherin staining.

285 The concomitant appearance of opsin and peripherin strongly suggests roles in promoting the stru

286 ic structural proteins (e.g. neurofilaments, peripherin, Talpha1-tubulin) have revealed potential reg

287 The earlier peak expression of peripherin than the triplet during brain development and

288 e effects of a transgene encoding normal rds/peripherin that had integrated into the X-chromosome in

289 ysis to include the four light NF subunits - peripherin, the light NF triplet protein (NF-L), and two

290 n transgenic mice via expression of a mutant peripherin transgene under control of peripherin gene re

291 critical, mice were generated that expressed peripherin transgenes lacking different introns.

292 As for the cytoskeletal proteins beta-actin, peripherin, vimentin, gamma-tropomyosin 3, and cofilin 1

293 Two new homologs of rds/peripherin were discovered: crds1 and crds2.

294 segment proteins (the cGMP-gated channel and peripherin) were examined and found to be sorted normall

295 yclic GMP phosphodiesterase (PDE6B), and RDS/peripherin, were excluded.

296 presents the chick ortholog of mammalian rds/peripherin, whereas crds2 is a more distant homolog.

297 s is suppressed by the disc-specific protein peripherin, which enables retained ectosomes to be morph

298 sed throughout regeneration, whereas that of peripherin, which is abundant in developing axons, incre

299 ression of the intermediate filament protein peripherin, which is associated with CNS neuronal injury

300 bled a mutant rds transgene that encodes rds/peripherin with a P216L substitution.