ライフサイエンスコーパス: perivascular niche

1 l carcinomas (HNSCC) close to blood vessels (perivascular niche).

2 (LepR+) cells led to a disruption of the BM perivascular niche.

3 cells (CSCs) and their association with the perivascular niche.

4 ma stem-like cells (MSLC) accumulated in the perivascular niche.

5 n and contribution to GSC maintenance in the perivascular niche.

6 ting that quiescent HSCs are maintained by a perivascular niche.

7 ifferentiation as long as they reside in the perivascular niche.

8 o-resistant medulloblastoma cells occupy the perivascular niche.

9 neuronal progenitor cell interactions in the perivascular niche.

10 roportion of surviving MSCs integrating in a perivascular niche.

11 ng BCC dedifferentiation into CSCs at the BM perivascular niche.

12 ) PRTG(+ve) stem cells inhabiting a specific perivascular niche.

13 ells (SKBR3) to factors present in the brain perivascular niche.

14 ound that surviving RGCs are enriched in the perivascular niche.

15 cancer cells (GSCs) that home to specialized perivascular niches.

16 vascular pericytes that may actively remodel perivascular niches.

17 growth factor secretion and are enriched in perivascular niches.

18 els produced CCL19, guiding CCR7(+) DCs into perivascular niches.

19 When an HSPC arrives in the perivascular niche, a group of endothelial cells remodel

20 nce is associated with a spatially localized perivascular niche, a phenotype acquired through an inte

21 sed in the tumor cell niches compared to the perivascular niche across multiple regions in GBM patien

22 of pericyte-based therapy for restoring the perivascular niche after myocardial infarction.

23 Stem-like glioma cells reside within a perivascular niche and display hallmark radiation resist

24 ellular niches in bone marrow: HSCs occupy a perivascular niche and early lymphoid progenitors occupy

25 s within skin injuries, where they home to a perivascular niche and generate alternatively activated,

26 subsets were topographically adjacent to the perivascular niche and had close spatial interactions wi

27 ling axis as crucial for exploitation of the perivascular niche and identify potential therapeutic ta

28 that of maintaining the integrity of the BM perivascular niche and improving BM niche recovery after

29 Because GSCs often reside in perivascular niches and may undergo mesenchymal differen

30 e findings demonstrate how vessel co-option, perivascular niche, and GBM cell plasticity jointly driv

31 Interactions with the adjacent perivascular niche are an important driver of malignancy

32 Perivascular niches are specialized microenvironments wh

33 critical function in morphogenesis of these perivascular niches as well as in melanoma tumorigenicit

34 Haematopoietic stem cells (HSCs) reside in a perivascular niche but the specific location of this nic

35 elial cell branching and inflammation in the perivascular niche by upregulating the pro-inflammatory

36 ting HSCs, activation of bone marrow Lepr(+) perivascular niche cells expressing IL-1 receptor is cri

37 d, tumor-initiating stem cells housed in the perivascular niche close to remaining blood vessels were

38 rounded by ALDH1(high) or Bmi-1(high) cells (perivascular niches) compared to tissues formed upon tra

39 To simulate perivascular niche conditions and analyze consequential

40 Collectively, perivascular niche conditions promote GBM growth and inv

41 TSC1-deficient TAMs relocated to a perivascular niche, depleted protein C receptor (PROCR)-

42 te that the upper bulge is associated with a perivascular niche during the establishment and maintena

43 genes induced rapid release of GICs from the perivascular niche, followed by tumor regression.

44 We sought to determine whether there is a perivascular niche for hair follicle stem cells.

45 The perivascular niche for neurogenesis was first reported a

46 of GTPases in endosteal/osteoblastic versus perivascular niche function.

47 CD44(+) CSCs in perivascular niches generate the majority of vascular pe

48 s that can target the heart's highly plastic perivascular niche have been proposed.

49 Here, we report that SCC cells within the perivascular niche have undergone epithelial to mesenchy

50 oietic stem cells (HSCs) are maintained by a perivascular niche in bone marrow but it is unclear whet

51 oietic stem cells (HSCs) are maintained in a perivascular niche in bone marrow, in which leptin recep

52 endothelial cells and stem cells within the perivascular niche in dental pulps is unclear.

53 ng VM and the morphogenesis of a specialized perivascular niche in melanoma.

54 Thus, HSCs reside in a perivascular niche in which multiple cell types express

55 nvestigating the effect of laminin alpha4 on perivascular niches in adipose tissue.

56 in human tumors, suggesting the existence of perivascular niches in HNSCC.

57 nous matrices that are soft and 2D, like the perivascular niches in marrow rather than 3D or rigid, l

58 Perivascular niches in the kidney comprise heterogeneous

59 vironment modulate the fate of stem cells in perivascular niches in tissues (e.g., bone) and organs (

60 d identified seven RGC types enriched in the perivascular niche, including direction-selective RGC (D

61 endothelial cells and stem cells within the perivascular niche is required for the maintenance of st

62 R exhibited more physiologically relevant BM perivascular niche markers compared to static culture mo

63 ing that the loss of extrinsic cues from the perivascular niche may also contribute to their myeloid

64 errogating the codependence of BTSCs and the perivascular niche may directly inform clinical approach

65 one marrow and spleen, HSCs are sustained in perivascular niches (microenvironments) associated with

66 idual-tumor after macrometastasis resection, perivascular niche micrometastasis, and leptomeningeal m

67 mesenchymal progenitor cells located in the perivascular niche of human endometrium, but the existen

68 Mesenchymal stem cells (MSCs) reside in the perivascular niche of many organs, including kidney, lun

69 r positions effector-like CTLs in a discrete perivascular niche of the tumor stroma that is densely o

70 Evidence has emerged for macrophages in the perivascular niche of tumors regulating important proces

71 ether, these data suggest that in the glioma perivascular niche, osteopontin promotes stem cell-like

72 Some adult animals presented perivascular niches outside the V-SVZ.

73 We show that chemoresistant DTCs occupy the perivascular niche (PVN) of distant tissues, where they

74 f SHH-producing stromal cells that reside in perivascular niche (PVN), namely low-cycling astrocytes

75 However, the mechanisms by which the perivascular niche regulates GBM invasion and CSCs remai

76 geting the PRTG(high) compartment and/or the perivascular niche represents an approach to treat child

77 on of breast cancer cells at the bone marrow perivascular niche requires mesenchymal stem cell-derive

78 thelial cells (EC) in what has been termed a perivascular niche, spurring investigation into the role

79 Adventitial perivascular niches surround larger blood vessels and ot

80 model of the spatiotemporal dynamics of the perivascular niche that incorporates glioblastoma stem-l

81 bpopulations are colocalized in melanomas in perivascular niches that contain CD144 (VE-cadherin)(+)

82 llum of children and contain stem cells in a perivascular niche thought to give rise to recurrence fo

83 reby enriching for deposition of MSLC in the perivascular niche through an HIF1alpha-dependent proces

84 (MSCs) are recruited from the endosteal and perivascular niche to become fibrosis-driving myofibrobl

85 st that preservation of the integrity of the perivascular niche via VEGF-C signaling could be exploit

86 The importance of the perivascular niche was further suggested by the fact tha

87 ming abilities, with the majority located in perivascular niches where GSCs are found.

88 Furthermore, YAP1 is found in cells of the perivascular niche, where proposed tumor-repopulating ce

89 Bulk RNAseq revealed cells in the perivascular niche which express the high levels of Pdgf

90 pts this positive feedback loop in the tumor perivascular niche, which eventually lessens tumor initi

91 netrant medulloblastoma originating from the perivascular niche, which exhibited abnormal blood vesse

92 e surrounding brain tissue and homing to the perivascular niche, which in turn induces even more VC-R