ライフサイエンスコーパス: perivascular space

1 he artery and breaks tissue tolerance in the perivascular space.

2 productively infected MNLs into a potential perivascular space.

3 ased number of Gaucher cells in the cerebral perivascular space.

4 ron-laden macrophages, predominately seen in perivascular space.

5 blue around the nerves in the hepatic hilar perivascular space.

6 was found in myeloid populations and in the perivascular space.

7 lls can engraft in the cerebral vascular and perivascular space.

8 allowing substances in the CSF to enter the perivascular space.

9 lexity of regulation of hematopoiesis in the perivascular space.

10 s play an important role in the integrity of perivascular space.

11 al stromal cells (MSCs) are important in the perivascular space.

12 l TSP-1 upregulation in the interstitial and perivascular space.

13 nels and elevate [K(+)](o) in the restricted perivascular space.

14 humoral immunity targeting an antigen in the perivascular space.

15 e immune responses from mucosal surfaces and perivascular spaces.

16 lymphocytes in both the brain parenchyma and perivascular spaces.

17 sular foci at MR imaging are due to enlarged perivascular spaces.

18 of CD68+ macrophages in the interstitial and perivascular spaces.

19 o) type, and they phagocytosed fibrinogen in perivascular spaces.

20 on of white matter tracts and penetration of perivascular spaces.

21 laying a role in enlargement of white matter perivascular spaces.

22 sing microglia in fetal brain parenchyma and perivascular spaces.

23 phatic assessment with detection of enlarged perivascular spaces.

24 spaces in concentric shells surrounding the perivascular spaces.

25 11195 binding (P < 0.001) in the vicinity of perivascular spaces.

26 matrix and reduces NP confinement within the perivascular spaces.

27 t, Tregs were restricted to the meninges and perivascular spaces.

28 ter confinement of CD4(+) lymphocytes to CNS perivascular spaces.

29 9 expression was confined to the vasculature/perivascular spaces.

30 in deposition was found in blood vessels and perivascular spaces.

31 most infiltrating cells remain localized to perivascular spaces.

32 oid space and infiltrated the Virchow-Robin (perivascular) space.

33 erivascular macrophages (PVM) located in the perivascular space, a major site of brain Abeta collecti

34 eased burden of frontal cortical MRI-visible perivascular spaces, a putative neuroimaging marker of g

35 diffusion-tensor imaging analysis along the perivascular space (ALPS) index, is involved in developm

36 Rac in the Nestin(+) cells would perturb the perivascular space, altering HSC localization and hemato

37 ecruitment prolonged T cell retention in the perivascular space, although no difference in overall CN

38 endfeet syncytium abutting subarachnoid and perivascular spaces, although direct evidence remains in

39 Here, we review perivascular space anatomy, physiology and pathology, pa

40 ity that allowed angiotensin II to enter the perivascular space and activate angiotensin type 1 recep

41 ich are immune cells that are present in the perivascular space and are a major peripheral source of

42 culating leukocytes to transmigrate into the perivascular space and brain parenchyma.

43 ancer cells were specifically located in the perivascular space and closely associated with blood ves

44 CD40(-/-) mice, T cells were retained in the perivascular space and did not migrate into the parenchy

45 essing mononuclear cells into and out of the perivascular space and leading to progression of disease

46 ouble-negative CD3(+)CD4(-)CD8(-) T cells in perivascular space and reduced vascular oxidative stress

47 rebral ischemia, CD8+ T cells infiltrate the perivascular space and secrete interleukin-16 (IL-16), a

48 HSCs moved in the perivascular space and showed intermittent close contact

49 roid plexus in early inflammation and in the perivascular space and SIV encephalitis (SIVE) lesions l

50 CD163(+) macrophages accumulated in the perivascular space and SIVE lesions with late inflammati

51 fluid changes are correlated with changes to perivascular space and spaceflight associated neuro-ocul

52 s not required for monocyte migration to the perivascular space and that vascular remodeling followin

53 entitially released drug is cleared from the perivascular space and those by which drug enters the bl

54 ciations between the burden of basal ganglia perivascular spaces and 11C-PK11195 binding.

55 t the bottlenose dolphin possesses prominent perivascular spaces and aquaporin-4 astroglial water cha

56 There was no association between markers of perivascular spaces and blood biomarkers of systemic inf

57 We investigated the relationship between perivascular spaces and both CNS and peripheral inflamma

58 acytic inflammation, with a predilection for perivascular spaces and collagenous tissues, was observe

59 vasoconstriction, which in turn enlarged the perivascular spaces and doubled glymphatic inflow speeds

60 the morphological and functional aspects of perivascular spaces and how those spaces can be visualiz

61 r matrix proteins, obstructing CSF access to perivascular spaces and impairing CNS perfusion and clea

62 p<0.05, and also showed significant rises in perivascular spaces and in cortical parenchyma.

63 arenchyma towards the outer surfaces and the perivascular spaces and is formed by a subset of astrocy

64 Here, we showed that perivascular spaces and meningeal lymphatic vessels form

65 lation of mature thymocytes within medullary perivascular spaces and reduced numbers of recent thymic

66 odies exhibited size-dependent access to the perivascular spaces and tunica media basement membranes

67 he deposited drug diffuses directly from the perivascular space, and little arrives from the endovasc

68 eds, white matter hyperintensities, enlarged perivascular spaces, and brain atrophy.

69 t in border regions, including the meninges, perivascular spaces, and choroid plexus.

70 ealed white matter hyperintensities, dilated perivascular spaces, and lacunar infarction.

71 cal superficial siderosis, centrum semiovale perivascular spaces, and white matter hyperintensities.

72 cal superficial siderosis, centrum semiovale perivascular spaces, and white matter hyperintensities.

73 rtical infarcts, microinfarcts, microbleeds, perivascular spacing, and white matter attenuation is co

74 to measure them in the brain, studies in the perivascular space are lacking.

75 Enlarged perivascular spaces are a feature of cerebral small vess

76 Our findings demonstrate that white matter perivascular spaces are associated with increased 11C-PK

77 The mechanisms underlying enlargement of perivascular spaces are not fully understood, but both i

78 The forces driving CSF mobility within perivascular spaces are still debated.

79 caused by a leak of blood and fluid into the perivascular space around the artery, as in several pati

80 hed to VE-cadherin(+) cells, implicating the perivascular space as a near-homogenous location of LT-H

81 We detected NOA-Au into perivascular spaces as early as 30 sec after the beginni

82 the endothelium; (iii) it is detected in the perivascular spaces at early time points (by 1 min) and

83 rocess that requires cells to pass through a perivascular space before entering the parenchyma.

84 with the flow in the thin annular gap of the perivascular space between an impermeable artery and the

85 The subarachnoid space and associated perivascular spaces between the membranes of the meninge

86 ensity - WMH, microbleeds, lacunes, enlarged perivascular spaces, brain atrophy) as seen on structura

87 Higher white matter perivascular spaces burden on the visual rating scale wa

88 he meninges, injection site, ventricles, and perivascular spaces but not in the parenchyma.

89 m-dependent activation of the T cells in the perivascular space, but not within the vascular lumen.

90 orrhages where plasma fibrinogen leaked into perivascular spaces, but it did not affect the distribut

91 associated with increasing age and enlarged perivascular spaces, but these did not explain the lacun

92 Drug released into the perivascular space can enter the artery either from the

93 hite matter hyperintensities (WMH), enlarged perivascular spaces, cerebral microbleeds and lacunes.

94 al (thymic epithelial space) and peripheral (perivascular space) components that functions well into

95 ild inflammatory exudates, in endomysial and perivascular spaces, consisted of lymphocytes, histiocyt

96 An improved understanding of perivascular spaces could advance our comprehension of t

97 vasodilation of bridging veins and reducing perivascular spaces critical for CSF drainage.

98 highly dendritic cells localized within the perivascular space, dermal-epidermal junction, and retic

99 infarcts, microinfarcts, arteriolosclerosis, perivascular space dilation and myelin loss-predicted co

100 orrhage, fibrinoid necrosis, microaneurysms, perivascular space dilation, perivascular haemosiderin l

101 white matter, tissue in closest proximity to perivascular spaces displayed greater 11C-PK11195 bindin

102 d to characterize how drug released into the perivascular space enters the arterial wall and how it i

103 Enlarged perivascular spaces (EPVS) are a promising neuroimaging

104 able, 3D neural network for grading enlarged perivascular spaces (EPVS) severity at the level of the

105 (PVWM) and deep white matter (DWM), enlarged perivascular spaces (ePVS), lacunar strokes, and cerebra

106 hite matter hyperintensities (WMH), enlarged perivascular spaces (EPVS), microbleeds and lacunes.

107 Enlarged perivascular spaces (EPVS), specifically in stroke patie

108 Enlarged perivascular spaces (ePVSs) have been associated with ce

109 ject-based morphologic estimates of enlarged perivascular spaces (ePVSs) in clinical-field-strength (

110 thereby drains the brain's interstitial and perivascular spaces, facilitates outward signaling beyon

111 enlargement and eccentric thickening of the perivascular space (fibrillar collagen type I deposition

112 brainwide CSF transport system that uses the perivascular space for fast inflow of CSF.

113 mas are highly invasive tumours that use the perivascular space for invasion and co-opt existing vess

114 oth small and large molecule agents into the perivascular space from the cerebrospinal fluid.

115 pace may provide unique entry sites into the perivascular spaces from the CSF.

116 advances have facilitated in vivo studies of perivascular space function in intact rodent models duri

117 remain, but what is now clear is that normal perivascular space function is important for maintaining

118 have pleomorphic lymphoid infiltrates in the perivascular spaces, had significantly increased numbers

119 lthough T cells could reach the meninges and perivascular space in the absence of TNFR1, recruitment

120 te matter characteristic (ie, severe visible perivascular spaces in centrum semiovale or white matter

121 Severe perivascular spaces in centrum semiovale were common at

122 eability in the local vicinity of individual perivascular spaces in concentric shells surrounding the

123 ive review is to summarize the literature on perivascular spaces in human neuroinflammation and assoc

124 e number of dendritic cells (DC) in cerebral perivascular spaces in multiple sclerosis (MS).

125 eins SPP1 and COL6A1 accumulated in enlarged perivascular spaces in patients with sporadic ALS.

126 grade), whereas the severity of MRI-visible perivascular spaces in the basal ganglia was associated

127 justed analyses, the severity of MRI-visible perivascular spaces in the centrum semi-ovale was indepe

128 We also hypothesized that MRI-visible perivascular spaces in the centrum semi-ovale would be a

129 's disease, we hypothesized that MRI-visible perivascular spaces in the centrum semi-ovale would be a

130 nocytes into the choroid plexus stromata and perivascular spaces in the cerebra of rhesus macaques ac

131 iods when fluid and solutes are driven along perivascular spaces in the reverse direction to the flow

132 ng scale and by measurement of the volume of perivascular spaces in the white matter and the basal ga

133 e attachment of solutes to the lining of the perivascular space, in order to produce a valve-like eff

134 Perivascular spaces include a variety of passageways aro

135 en cerebrospinal fluid (CSF) influx from the perivascular spaces into the interstitial fluid space ra

136 though almost all the drug released into the perivascular space is cleared through the extravascular

137 n through the endothelial cell wall into the perivascular space is well characterized; however, mecha

138 nship between neuroinflammation and enlarged perivascular spaces is causal.

139 Cerebrospinal fluid (CSF) drains along the perivascular space, known as the glymphatic system, to t

140 However, whether large perivascular spaces (L-PVSs) (>3 mm in diameter) visible

141 uding white matter hyperintensities, dilated perivascular spaces, lacunar infarcts, microbleeds, and

142 on structural MRI, visual scores and volume; perivascular spaces; lacunes and microbleeds), and vascu

143 ucuronidase reached brain parenchyma via the perivascular spaces lining blood vessels.

144 CSF mobility in humans, down to the level of perivascular spaces located around penetrating vessels,

145 Using MRI-visible perivascular space location and severity together with o

146 e more than a century of intense research on perivascular spaces, many open questions remain about th

147 t the anatomical distribution of MRI-visible perivascular spaces may reflect the underlying cerebral

148 cts, lacunes, white matter hyperintensities, perivascular spaces, microbleeds, and brain atrophy.

149 ess and sleep, and MRI in humans has enabled perivascular space morphology to be related to cognitive

150 ted by vascular dynamics, the maintenance of perivascular spaces, neural activity during sleep, and l

151 within Gelfoam matrices and implanted in the perivascular space of 42 injured arteries.

152 epileptiform discharges, WBCs populated the perivascular space of a leaky BBB.

153 inent lymphocyte population infiltrating the perivascular space of choroidal neovascularization (CNV)

154 lium controls repair even when placed in the perivascular space of injured vessels.

155 and inflammatory cells that appeared in the perivascular space of intramural coronary arteries and a

156 scence revealed prelabeled MAPC cells in the perivascular space of kidneys during NMP.

157 quantify human brain CSF dynamics along the perivascular space of major arteries and their branches.

158 find that glioma cells, as they populate the perivascular space of preexisting vessels, displace astr

159 exclusively target the meninges and vascular/perivascular space of the gray and white matter of the b

160 ion or fibrosis in the media, adventitia, or perivascular space of vessels treated with the beta-part

161 ophages in the choroid plexus, meninges, and perivascular spaces of aged AD mice versus WT control mi

162 distribution to deep brain regions along the perivascular spaces of all vessel types, with sdAb acces

163 to inflammatory changes in the meninges and perivascular spaces of both wild-type and complement-def

164 fluid, although convective transport in the perivascular spaces of cerebral blood vessels was also e

165 he brain surface and convective transport in perivascular spaces of cerebral blood vessels.

166 rne macrophages repopulated the meninges and perivascular spaces of chimeric animals.

167 nto the cisterna magna of mice migrate along perivascular spaces of dural blood vessels and then trav

168 y age-dependent human CSF dynamics along the perivascular spaces of major brain arteries.

169 microscopic examination, these cavities were perivascular spaces of mostly arteriolar origin.

170 sed numbers in both the brain parenchyma and perivascular spaces of pre-AIDS brains.

171 present in the meninges, choroid plexus and perivascular spaces of the brain and spinal cord.

172 rease influx of cerebrospinal fluid into the perivascular spaces of the brain, to enhance the uptake

173 sing exchangeable Zn2+ concentrations in the perivascular spaces of the brain.

174 OR = 0.94, 95% CI = 0.89 to 0.99), and fewer perivascular spaces (OR = 0.95, 95% CI = 0.91 to 0.99).

175 It is uncontested that perivascular spaces play critical roles in maintaining h

176 tions to localize infiltrating leukocytes to perivascular spaces, preventing CNS parenchymal infiltra

177 The glymphatic system, a network of perivascular spaces promoting fluid exchange between CSF

178 fluorescently labeled albumin tracer in the perivascular space (PVS) along microvessels, primarily t

179 Perivascular space (PVS) burden is an emerging, poorly u

180 ctive bulk flow of solutes in the CSF in the perivascular space (PVS) is considered one of the import

181 The flow inside the perivascular space (PVS) is modeled using a first-princi

182 The perivascular space (PVS) of human thymus increases in vo

183 Perivascular space (PVS) within the brain is an importan

184 rain and increased their presence within the perivascular space (PVS).

185 ite matter lesion load, frequency of dilated perivascular spaces (PVS) and abnormalities in cerebral

186 Perivascular spaces (PVS) and cerebrospinal fluid (CSF)

187 ssel disease (cSVD), solute transport in the perivascular spaces (PVS) and PVS-to-tissue transfer was

188 MRI-visible perivascular spaces (PVS) are potential neuroimaging mar

189 Perivascular spaces (PVS) drain brain waste metabolites,

190 to analyze the alterations occurring in the perivascular spaces (PVS) in NASA and European Space Age

191 brospinal fluid (CSF) flow along the brain's perivascular spaces (PVS), aiding in the removal of harm

192 Imaging the perivascular spaces (PVS), also known as Virchow-Robin s

193 infarcts, cerebral microbleeds, and enlarged perivascular spaces (PVS), as well as PET-based biomarke

194 hite matter hyperintensities (WMH), enlarged perivascular spaces (PVS), microbleeds, and infarcts eme

195 spaces around cerebral blood vessels, called perivascular spaces (PVS), through which cerebrospinal f

196 Perivascular spaces (PVSs) in brain have a close relatio

197 th advancing age, an increased visibility of perivascular spaces (PVSs) on magnetic resonance imaging

198 thway was defined in rodents as a network of perivascular spaces (PVSs) that facilitates organized di

199 tributions of diffusion and advection in the perivascular spaces (PVSs) that surround penetrating cor

200 have evaluated the effects of spaceflight on perivascular spaces (PVSs) within the brain, which are b

201 (PI), white matter lesions (WMLs), enlarged perivascular spaces (PVSs), and lacunar infarcts are com

202 n cerebrospinal fluid (CSF) flow through the perivascular spaces (PVSs, annular channels lining the b

203 Many questions about perivascular spaces remain, but what is now clear is tha

204 Ms in the choroid plexus, leptomeninges, and perivascular spaces required CSF-1, while IL-34 was crit

205 Infiltration of splenic blood vessel perivascular spaces resulted in vascular compression and

206 MRI-visible perivascular space severity in either location did not p

207 rrected P = 0.009); values for the volume of perivascular spaces showed a similar trend.

208 ibe patterns of contrast distribution in the perivascular space, subarachnoid space, and space surrou

209 genesis, the migration of monocytes into the perivascular space surrounding collateral arteries and t

210 have shown evidence of pulsatile CSF flow in perivascular spaces surrounding pial arteries, with a bu

211 et flow of cerebrospinal fluid (CSF) through perivascular spaces surrounding veins and arteries.

212 el consisting of the vascular smooth muscle, perivascular space, synaptic space, and astrocyte glial

213 can, are not abundant in brain except in the perivascular space that is contacted by astrocytes but n

214 Perivascular spaces that are visible on magnetic resonan

215 The glymphatic system is a network of perivascular spaces that promotes movement of cerebrospi

216 LMPCs were present in the perivascular space, the walls of small and large arterie

217 We identified niches such as perivascular spaces, the inflamed lesion rim or the lesi

218 ze CXCR4-expressing mononuclear cells to the perivascular space, thereby limiting the parenchymal inf

219 channels, which locally release K+ into the perivascular space to activate SMC Kir channels and caus

220 ween CSF velocity curves in the aqueduct and perivascular spaces to assess their relationship.

221 cell types and structures in and around the perivascular spaces to support normal CNS vascular funct

222 mall deep infarcts, microbleeds, or enlarged perivascular spaces) to severe disability and cognitive

223 ation away from their vitronectin-containing perivascular space toward fibronectin-rich tumor tissue.

224 appeared to be iron-laden macrophages in the perivascular space tracking a network of injured vessels

225 and blood vessels determine the shape of the perivascular space, ultimately controlling the movement

226 Perivascular space was detected using a dilation algorit

227 -carboxybenzoylsulphonamide (TFL-Zn)] in the perivascular space was significantly decreased in the ne

228 No marker of perivascular spaces was correlated with blood-brain barr

229 Although perivascular spaces were first identified over 150 years

230 Perivascular spaces were quantified both using a visual

231 Enlarged perivascular spaces were quantified using a fully automa

232 MRI-visible perivascular spaces were rated using a validated 4-point

233 hite matter hyperintensities [WMH], lacunes, perivascular spaces) were assessed on 3T magnetic resona

234 on MRI] microbleeds, siderosis, and enlarged perivascular spaces) were retrospectively assessed while

235 tivation, and T-cell transmigration into the perivascular space, where (ii) blinatumomab induced B-ce

236 e latter, FAP expression was confined to the perivascular space, whereas neoplastic cells additionall

237 distinct CD206+ macrophage population in the perivascular space, which may modulate T cell entry into

238 optic nerve sheath, the neural axon, and the perivascular space, which might represent the critical s

239 Recent discoveries highlighted perivascular spaces, which are cerebrospinal fluid (CSF)

240 cytes were detected only in the vascular and perivascular spaces while albumin and IgG extravasates w

241 d with inflammation of the vascular wall and perivascular space with cells of monocyte/microglia line

242 ubset of white matter vessels have increased perivascular space (with jagged contours) and collagen i

243 have each been shown to drive CSF flow along perivascular spaces, yet it is unknown how such pulsatio

244 method for multimodal autoidentification of perivascular spaces yields individual whole-brain morpho