ライフサイエンスコーパス: permeability

1 ased plasminogen and a decreased fibrin clot permeability.

2 f MYLK-L-induced SOCE in increasing vascular permeability.

3 in occludin mRNA and the increase in colonic permeability.

4 ble potentiated enhancement of microvascular permeability.

5 s, increased Rap1-dependent endothelial cell permeability.

6 esponse using in vitro models of endothelial permeability.

7 e network together determines the total bulk permeability.

8 ssel morphogenesis, angiogenesis, and tissue permeability.

9 on expression of TJ proteins and intestinal permeability.

10 n hair does not lead to an increase of water permeability.

11 gh injections only, due to its poor membrane permeability.

12 tly with bacteremia and increased intestinal permeability.

13 ition to nontoxicity and blood-brain barrier permeability.

14 ess fibers and increased endothelial barrier permeability.

15 udin by enterocytes and thereby increases TJ permeability.

16 n of claudin-5, to thus decrease endothelial permeability.

17 ted to better understand their role in water permeability.

18 ons, in the mechanism of EC inflammation and permeability.

19 e in maintaining cell membrane integrity and permeability.

20 ight-junction protein in blood-brain-barrier permeability.

21 given the impact of burrows on porosity and permeability.

22 biosynthesis, respiration rate and membrane permeability.

23 s fiber formation and increased paracellular permeability.

24 rticles (such as silica) conferring enhanced permeability.

25 -oxadiazole analogues may have limited brain permeability.

26 anized the cell-cell junction, and increased permeability.

27 eir virulence by changing the outer membrane permeability.

28 ch is known to be associated with reduced PD permeability.

29 ion of altered asperities can rapidly reduce permeability.

30 atment and is required for histamine-induced permeability.

31 of gas hydrate saturation change on relative permeability.

32 -based 3D-PSA is a good predictor of passive permeability.

33 glycocalyx is a vital regulator of vascular permeability.

34 light chain phosphorylation and increase in permeability.

35 upling paracellular and transcellular sodium permeability.

36 how increased metabolic stability and Caco-2 permeability.

37 s fiber formation and prevented paracellular permeability.

38 lity but occasionally at the cost of reduced permeability.

39 esulting in recovery of membrane packing and permeability.

40 TAR particles, to dramatically increase skin permeability.

41 in II to control vasodilatation and vascular permeability.

42 ology of U-HAE increasing the basal vascular permeability.

43 action with blood constituents, and vascular permeability.

44 nd (iii) increases of porosity (by ~ 6%) and permeability (~ 7%).

45 ta6 association as well as TGF-beta-mediated permeability across alveolar epithelial cells.

46 t and behavior by regulating steroid hormone permeability across the BBB.

47 they induce which in turn is related to the permeability across the epithelial membrane, a parameter

48 nockout of miR-34a significantly reduces BBB permeability, alleviates disruption of tight junctions,

49 t inflammation (myeloperoxidase, neopterin), permeability (alpha-1-antitrypsin, lactulose, mannitol),

50 tides can achieve surprisingly high membrane permeability, although the properties that govern permea

51 ous distinct features, including non-uniform permeability and active efflux of molecules.

52 co-culture model was used to assess the BBB permeability and anti-tumor activity of the DOX-EDT-IONP

53 The peptide induces bacterial membrane permeability and ATP release, with serial passaging resu

54 hemical reactions to modulate their membrane permeability and binding affinity.

55 ld, significantly enhanced both DOX-EDT-IONP permeability and cytotoxicity in the MDCK-MDR1-GBM co-cu

56 ributes to the BMB2-dependent increase in PD permeability and formation of the PD-associated replicat

57 pression, PHIVs have evidence of altered gut permeability and fungal translocation.

58 findings resolve conflicting reports on the permeability and gating properties of TPC2 and they esta

59 er engraftment, partially impairing vascular permeability and glucose delivery to beta-cells.

60 oethylene (PTFE) matrix that imparts low gas permeability and high mechanical strength but introduces

61 ndothelial glycocalyx regulates blood vessel permeability and homeostasis.

62 view the mechanisms that regulate intestinal permeability and how changes in the intestinal microbiom

63 een the pore and leak pathways of intestinal permeability and immune responses leading to colitis.

64 tly decreased lung injury, inflammation, and permeability and improved hemodynamics.

65 to measure increased islet microvasculature permeability and indicate asymptomatic T1D.

66 -field model considers spatial variations in permeability and material properties within a single uni

67 Recently we showed blood brain barrier (BBB) permeability and memory loss are associated with diminut

68 nesses is associated with increased vascular permeability and mortality.

69 ne results in compounds with favorable brain permeability and multiple activities in vitro (acetylcho

70 of the selectivity filter to enhance calcium permeability and opening of a canonical gate at the cyto

71 7f, 7g, and 9k, that addressed cell membrane permeability and other physicochemical issues.

72 Vascular permeability and plasma leakage are immune-pathologies o

73 Coupling between fluid flow, permeability and pressure evolution, and slip produces f

74 coated stents results in diminished vascular permeability and reduced foam cell formation compared to

75 of Caco-2 monolayers with IL1B increased TJ permeability and reduced levels of occludin protein and

76 ines for cancer therapy based on the enhance permeability and retention (EPR) effect remain insuffici

77 testinal mucosa increases epithelial barrier permeability and reveals type I IFNs and CD8 T cells as

78 d contemporary lipophilicity measurements on permeability and solubility, showing that the distributi

79 I3Kalpha(H1047R) ducts also elicit increased permeability and structural disorganization of the endot

80 AP did not affect the water vapor permeability and tensile strength of the OSA-based carri

81 We observe a relation between the molecule permeability and the saturation of the lipid acyl chain

82 d normalized compromised blood-brain barrier permeability and tight junction protein expression in th

83 g fluorescent dyes to measure outer-membrane permeability and to determine membrane depolarization.

84 rength, contact angle, porosity, water vapor permeability and water uptake ratio of CA/Gel nanofibers

85 ave been reported, but suffer from poor cell permeability and/or cross-reactivity with the cysteine p

86 er (airtight and pouches with different O(2) permeability) and packing conditions (cover brine, air o

87 ular interactions, key gene expressions, low permeability, and 3D astrocytic network with reduced rea

88 7.4 without altering paracellular HCO(3) (-) permeability, and calculated paracellular HCO(3) (-) flu

89 The naturally designed architecture, semi-permeability, and catalytic improvement of carboxysomes

90 ion and adherens junction, increased mucosal permeability, and elevated plasma LPS; TJ disruption by

91 ed severe hydrocephalus, blood-brain barrier permeability, and increased brain infiltration by myeloi

92 efficient RBC partitioning and high membrane permeability, and is not an efflux transporter (P-gp) su

93 inding affinity, unbound fractions in brain, permeability, and low efflux culminated in the discovery

94 H to ~7.0, increased paracellular HCO(3) (-) permeability, and paracellular HCO(3) (-) flux was negli

95 localization of TJ proteins, mucosal inulin permeability, and plasma lipopolysaccharide (LPS) levels

96 by an oxygen atom increases the solubility, permeability, and stability of three series of urea-base

97 system; facilitate blood flow; and regulate permeability, angiogenesis, inflammatory responses and h

98 Inflammation and vascular permeability are thought to be major contributors to the

99 audin-5 expression and decreased endothelial permeability, as measured by the passage of fluorescein

100 between alternating stereochemistry and high permeability, as well as a set of highly permeable conse

101 e discussed, including an ex vivo glomerular permeability assay that enhances the understanding of pe

102 Utilizing a quantitative intestinal permeability assay, we performed an unbiased GWAS screen

103 tract as assessed via a Caco-2 bidirectional permeability assay.

104 elial electrical resistance and FITC-dextran permeability assays.

105 se metabolites protect against increased gut permeability associated with a mouse model of colitis by

106 tests and an increase of blood-brain barrier permeability associated with renal dysfunction.

107 set of empirical parameters predict relative permeability at all S(h), (ii) includes the effect of ca

108 -binding probe to assess changes in vascular permeability at different stages of aneurysm growth.

109 (2+) inhibition of AMPARs by varying calcium permeability, auxiliary subunits, and activation levels

110 the cell, and the outer membrane serves as a permeability barrier against noxious compounds in the ex

111 The nuclear permeability barrier depends on closure of nuclear envel

112 uperfamily of proteins creating an efficient permeability barrier for antibiotics.

113 accharide molecule is a major element in the permeability barrier imposed by the outer membrane and o

114 r -incompetent cargo complexes, and then the permeability barrier properties of the droplets were opt

115 We show that the liquid state mimics permeability barrier properties of the physiological nuc

116 OM) of Gram-negative bacteria is a selective permeability barrier that allows uptake of nutrients whi

117 the OM's ability to function as a molecular permeability barrier that protects the bacterium against

118 ells to grow at 37 degrees C suggests the ER permeability barrier to be compromised in these mutants.

119 m-negative bacteria functions as a selective permeability barrier to the environment.

120 61 complex also functions to maintain the ER permeability barrier, preventing the mass free flow of e

121 escued the embryonic lethality and defective permeability barrier.

122 efflux pumps in the inner membrane creates a permeability barrier.

123 anslocase and is required to maintain the ER permeability barrier.

124 We quantify cell-cell permeability based on dye diffusion using mass transport

125 c macrocycles generally possess high passive permeability based on the PAMPA, yet their cellular perm

126 , PROTACs), increases in blood-brain barrier permeability (BBBP), and the targeting of allosteric poc

127 s than Apc(Min/+) mice and had increased gut permeability before tumor development, associated with r

128 cadDEE/DEE mutants exhibited normal vascular permeability but displayed microvascular patterning defe

129 increased molecular mobility, crystallinity, permeability but limited volatile release and reduced fi

130 silencing also reduced thrombin-mediated EC permeability by inhibiting the disassembly of VE-cadheri

131 n D (CypD), mortalin decreased mitochondrial permeability by inhibiting this interaction.

132 (HP) allele-2 gene, enhances the intestinal permeability by modulation of intercellular tight juncti

133 eas MEK-ERK activity increased mitochondrial permeability by promoting the interaction between ANT3 a

134 earing sediments where the proposed relative permeability can account for the evolving hydrate satura

135 This permeability can be tuned by a change of pH or the prese

136 which has a short primary effect on vascular permeability), can have severe secondary effects on neut

137 We performed assays to measure intestinal permeability, cell subsets, bacterial uptake and clearan

138 e pulmonary damage through reducing vascular permeability changes and recruitment of neutrophils into

139 ity assay that enhances the understanding of permeability changes in disease.

140 At high confining pressures (30 MPa), permeability changes were more sensitive to the measurin

141 More importantly, the permeability characteristics of human and porcine small

142 y brain microvascular endothelial cells, the permeability coefficient was measured following simulate

143 s on the number of permeable species; 2) the permeability coefficients (P) and the weak acid strength

144 Dysregulated endothelial permeability contributes to many conditions and can infl

145 wn about downstream mechanisms (ie, vascular permeability controlled by endothelial cells [ECs]).

146 fibrillary acidic protein in CSF, and in BBB permeability (CSF/serum albumin ratio).

147 ded because of lack of experimental relative permeability data.

148 More advanced aneurysms with higher vascular permeability demonstrated an increased uptake of the alb

149 Anion permeability depends both on how well CFTR channels work

150 y over a wide lipophilicity range, with peak permeabilities differing significantly depending on scaf

151 rrent was introduced that yields fusion pore permeability divided by vesicle volume (g/V).

152 te represents a very well-contained, low gas-permeability end member for past UNEs at the Nevada Nati

153 The permeability enhancers cause a decline in the TEER value

154 uses HVEPs to transiently increase membrane permeability, enhancing cellular cytotoxic drug uptake i

155 ining with its good machine washability, air permeability, flame-retardency, durability, and repeatab

156 ipid order, which coincides with low passive permeability for small molecules and a slow lateral diff

157 ibute along-shelf variability in salinity to permeability heterogeneity due to permeable conduits and

158 Increased permeability, IL-33 levels, type 2 innate lymphoid cell

159 lectrochemical method to measure endothelial permeability in a 3D hydrogel-based vascular model was d

160 variants that regulate radiation-induced gut permeability in adult D. melanogaster.

161 m mice, including reduced TEER and increased permeability in cocultures with human IEC or mouse enter

162 n brain endothelial cells that regulates BBB permeability in inflammatory conditions.SIGNIFICANCE STA

163 bserved a decrease in cuticle-dependent leaf permeability in maize seedlings exposed to drought as we

164 terleukin 1 beta (IL1B) increases intestinal permeability in mice.

165 opsy (FUS-LBx) that uses FUS to increase BBB permeability in murine glioblastoma models and thus enha

166 agonists also failed to increase endothelial permeability in MYLK-L-depleted EC and Mylk-L(-/-) lungs

167 of mediating increased mitochondrial proton permeability in old cardiomyocytes.

168 nd led to a significant enhancement of water permeability in oocytes.

169 g downstream of VEGFR2 pY949 limits vascular permeability in retinopathy induced by high oxygen or by

170 ability, although the properties that govern permeability in this chemical space are only beginning t

171 To address low permeability in transdermal patches, permeation enhancer

172 We measured changes in permeability in trophoblasts and stromal cores using a d

173 n across BMVEC monolayers, and increased BBB permeability in vitro.

174 mutant in Mylk-L(-/-) mice rescued vascular permeability increase in response to endotoxin, indicati

175 ck of well-defined damage zones, most of the permeability increase is controlled by fracture permeabi

176 In contrast, immune cells and permeability increased in HVs on PPIs.

177 r responses to FUS include enhanced vascular permeability, increased T cell infiltration, and tumor g

178 Antibody autoreactivity against bactericidal/permeability-increasing protein (BPI) is strongly associ

179 tains brain homeostasis and regulates solute permeability into brain tissue.

180 it may be mediated by differential compounds permeability into the cell.

181 ility based on the PAMPA, yet their cellular permeability is governed by efflux, as reported in the C

182 In vertebrates, epithelial permeability is regulated by the tight junction (TJ) for

183 reased sensitivity of NIR readouts for colon permeability is shown using dextran sulfate sodium (DSS)

184 The mechanism behind the enhanced permeability is the temporary creation of pores in cell

185 er chromatographic characterization showed a permeability (K(f)) of ~4 x 10(-15) m(2) and a total por

186 ne (PM) to form pores that increase membrane permeability, leading to pyroptosis and IL-1beta release

187 Increased endothelial permeability leads to excessive exudation of plasma prot

188 ncluding the vascular endothelium, regulates permeability, leukocyte traffic, nitric oxide production

189 (-/-) mice show reduced endothelial barrier permeability, lower leukocyte infiltration and reduced a

190 e production, ACC oxidase activity, membrane permeability, <beta>-galactosidase activity and, therefo

191 skin barrier function and increased bacteria permeability, making them a suitable model for diseases

192 Our permeability maps revealed an increase in slow blood-to-

193 , however, is typically limited to diffusive permeability measurements that are exclusively fluoresce

194 conditions, and following exposure to known permeability mediators.

195 ioral and neurological functions, intestinal permeability, metabolism, and intestinal microbiome dive

196 astic properties, thermal conductivities and permeabilities of reticulite show a fair agreement to ex

197 an serve as ultrafiltration membranes with a permeability of 143 L m(-2)h(-1)bar(-1) and a particle s

198 e presence and absence of ZIKV increased the permeability of anchoring villous explants.

199 The combined selective permeability of BR-bodies for both enzymes and substrate

200 As a proof-of-concept demonstration, the permeability of endothelial cells cultured on hydrogels

201 function, indicated by higher TEER and lower permeability of FD4 flux as well as increased proportion

202 e, 5-month diabetic rats exhibited increased permeability of FITC-albumin, and a single norrin inject

203 on conductance microscopy to measure the ion permeability of GO films and evaluate its relationship w

204 Permeability of HLMVEC and MLMVEC was similar under cont

205 delta-i had a significantly higher impact on permeability of HLMVEC.

206 and chorionic villi, resulting in increased permeability of human placentas.

207 of PTPN2-deficient macrophages, reducing the permeability of IEC monolayers in culture and in Ptpn2-L

208 either macrophages and/or IECs increased the permeability of IEC monolayers, had a synergistic effect

209 Here, we have compared the permeability of IP(3) and Ca(2+) through channels made f

210 chanical alteration of cement can reduce the permeability of leakage pathways.

211 Compared with control cells, the B-to-A permeability of mIBG increased by 20-fold in hOCT2/hMATE

212 However, the cell permeability of PROTACs is limited by their high molecul

213 servoir confinement (stress) on porosity and permeability of shales was investigated using two digita

214 ence-based approach for determination of the permeability of small molecules across the membranes of

215 tumor application partially because the low permeability of the blood-brain barrier (BBB) hinders th

216 tronger impairment in cognition and a higher permeability of the blood-brain barrier.

217 ich strongly depends on the rigidity and the permeability of the brain tissue.

218 to the PVS, depending on the elasticity and permeability of the brain.

219 The model hints that the plasma membrane permeability of the cells is not radially uniform but th

220 and formed mature tight junctions, that the permeability of the cholangiocyte monolayer was comparab

221 ochemical responses recorded showed that the permeability of the DMPC lipid membrane (tuned by additi

222 cretion including chemokines influencing the permeability of the endothelial barrier.

223 Nevertheless, the high permeability of the fracture system allowed for fast ove

224 es are pivotal in establishing the selective permeability of the glomerular filtration barrier.

225 The pharmacological activity and cellular permeability of the inhibitors were found to be sensitiv

226 hthiocerol dimycocerosate determined the low permeability of the mycobacterial outer membrane, and th

227 tion to establish and maintain the selective permeability of the OM.

228 The permeability of the plasma membrane (PM) for small molec

229 Porosity and permeability of the pre- and post-compression digital ro

230 Many Archaea maintain the fluidity and permeability of their membranes by adjusting the number

231 on Antarctic beaches led us to question the permeability of these barriers to species dispersal.

232 ork of ionic channels that exhibit regulated permeability of water and monovalent ions.

233 icrovascular leakage, the impact of vascular permeability on neutrophil trafficking is unknown.

234 mmon bean supplementation reduced intestinal permeability or increased linear growth.

235 rigid and chameleonic compounds showed high permeability over a wide lipophilicity range, with peak

236 MV displayed significantly increased dextran permeability over those infected with DeltaK/R-ab or its

237 Additionally, increased permeability persisted for months, as seen in players wh

238 th near-physiologic levels achieved with low-permeability PharMed tubing alone (128.0 +/- 14.0 mmHg).

239 When we parameterized the permeability-porosity relation using lower permeabilitie

240 lterations such as increased plasma membrane permeability, reduced resting membrane potential and acc

241 the first thorough analysis of the structure-permeability relationship of semipeptidic macrocycles.

242 Structure-permeability relationships have been extensively studied

243 e permeability-porosity relation using lower permeabilities reported by others, bond formation was in

244 bbles can efficiently increase cell membrane permeability resulting in enhanced tissue distribution a

245 Pharmacology and tracer permeability rule out coupling by gap junctions and puri

246 tatic interactions, and diffusion into lower-permeability soils.

247 However, predicted pK(a) and neutral permeabilities suggest that also the permeation of the n

248 ation owing to the hypebolicity of effective permeability tensor.

249 Results from a bovine corneal opacity and permeability test demonstrated slight irritation to the

250 ors such as non-uniform vascular density and permeability that limit the applicability of O2 carriers

251 the increase in tight junction macromolecule permeability that occurs following Alternaria exposure.

252 eters influencing the lipid membrane opening/permeability, the electrochemical detection of single re

253 The novel hBN-SSWC provides superior vapour permeability, thermal conductivity, electrical insulatio

254 ing duct cells, resulting in increased water permeability through regulation of the aquaporin-2 (AQP2

255 en delivery through PMCs is dependent on its permeability through the polymeric shell, the shell thic

256 C is damaged, resulting in enhanced vascular permeability, tissue edema, augmented leukocyte adhesion

257 The channel has high permeability to calcium relative to monovalent cations a

258 Thus, it is unclear whether permeability to individually injected exogenous tracers-

259 Reduced Cx50 permeability to IP(3) could play a role in regulating ce

260 The produced gas reduces the water relative permeability to less than 1% and, therefore, significant

261 ntly, the 2019 deck relies on solubility and permeability to select preferred compounds.

262 associated with a reduction in paracellular permeability to sodium, whereas decreased claudin-8 abun

263 ls are transmembrane proteins with selective permeability to specific charged particles.

264 ons of FJP and CG enhanced the thickness and permeability to water vapor, and made the films more hyd

265 that reduces mitochondrial Ca(2+) influx and permeability transition pore opening after ischemic inju

266 reperfusion injury by reducing mitochondrial permeability transition pore opening.

267 reperfusion injury by inducing mitochondrial permeability transition pore opening.

268 s, apoptosis, inflammation, or mitochondrial permeability transition pore opening.

269 We show that the mitochondrial permeability transition pore regulator cyclophilin D (Cy

270 ner mitochondrial membrane known as the PTP (permeability transition pore) and that opening of this p

271 re sensitive to Ca(2+)-induced mitochondrial permeability transition, suggesting that S-OPA1, and not

272 A variety of structure-permeability trends were observed including a relationsh

273 sociated with PDGF-BB delivery) and vascular permeability (triggered by VEGF-A).

274 ility to maintain size and/or membrane ionic permeability under prolonged salt stress.

275 the bacteria against increased cell-envelope permeability under subinhibitory cefoxitin treatment.

276 genes associated with changes in intestinal permeability upon radiation.

277 Therefore, accurate prediction of relative permeability using legacy models (e.g. Brooks-Corey (B-C

278 scans, we generated maps that visualized the permeability value for each brain voxel.

279 This pathway leads to an increase in permeability via phosphorylation of myosin light chain a

280 munostaining with isolectin B4, and vascular permeability was analyzed by fluorescein angiography.

281 Increased BBB permeability was confirmed by the significant increase (

282 ease-activated receptor-2-dependent vascular permeability was induced by pooled mature tryptases but

283 Intestinal permeability was measured after gavage with fluorescentl

284 Paracellular permeability was measured by using fluorescein isothiocy

285 A minimal effect of stress on porosity and permeability was observed in both 3D models.

286 FA/VEGF receptor 2 (VEGFR2)-induced vascular permeability, we show that targeting signaling downstrea

287 mAb on human umbilical vein endothelial cell permeability were assayed using a Transwell system.

288 Duodenal mucosal eosinophils, mast cells and permeability were quantified.

289 latory T (Treg) cells, as well as intestinal permeability, were evaluated in these pups.

290 olayers can be engineered with a spectrum of permeabilities, which points to a promising target for t

291 ition was found to significantly enhance the permeability, which directly led to the discovery of 7 (

292 meability increase is controlled by fracture permeability, which is sensitive to the coupled hydro-ch

293 stressors was associated with reduced mucus permeability, which may aid in survival.

294 unds had poor solubility properties and poor permeability, which was addressed utilizing two approach

295 olubility and provides control over cellular permeability while retaining their favorable spectroscop

296 junction organization to control endothelial permeability, with potential implications under patholog

297 oach to investigate and manipulate the shell permeability, with the intent of engineering BMC-based m

298 d tortuosity provides the best prediction of permeability, with the void-void correlation function be

299 The elongation at break and the water vapor permeability (WVP) values of the films were found to hav

300 al properties such as oxygen and water vapor permeability (WVP), swelling, water solubility and UV-vi