ライフサイエンスコーパス: permeability barrier

1 auses the loss of the membrane function as a permeability barrier.

2 on factor for the formation of the epidermal permeability barrier.

3 upporting a role for this nucleoporin in the permeability barrier.

4 as a bottom-up nanoscale model system of the permeability barrier.

5 The stratum corneum (SC) is an effective permeability barrier.

6 ponent of the glomerular endothelial protein permeability barrier.

7 e for a link between innate immunity and the permeability barrier.

8 efflux pumps in the inner membrane creates a permeability barrier.

9 to overcome the Gram-negative outer membrane permeability barrier.

10 profound defect in the cytoplasmic membrane permeability barrier.

11 d-bound cornified envelopes, and a defective permeability barrier.

12 anslocase and is required to maintain the ER permeability barrier.

13 fferentiation and formation of the epidermal permeability barrier.

14 R membranes into NE holes and a defective NE permeability barrier.

15 ave epidermal hyperkeratosis and a defective permeability barrier.

16 ion and its coupled translocation across the permeability barrier.

17 well as in the development of the epidermal permeability barrier.

18 evaluated the function of this membrane as a permeability barrier.

19 amellar membranes required for the epidermal permeability barrier.

20 dividual FG domains in yeast relaxes the NPC permeability barrier.

21 rkeratosis and a disruption in the epidermal permeability barrier.

22 all, providing structure and forming a major permeability barrier.

23 e in mediating the negative effects of SP on permeability barrier.

24 d outer membrane (OM), thus forming a robust permeability barrier.

25 rane without compromising its ion and proton permeability barrier.

26 re complex (NPC), which contains a selective permeability barrier.

27 e enzymes and the formation of the epidermal permeability barrier.

28 bladder epithelium functions as an effective permeability barrier.

29 aused only moderate damage to the intestinal permeability barrier.

30 , meiosis, and the integrity of the eggshell permeability barrier.

31 e-containing outer membrane, which acts as a permeability barrier.

32 PRn-mediated enhancement of the nuclear pore permeability barrier.

33 the vascular wall and endothelial glomerular permeability barrier.

34 in fenestrated endothelium with a functional permeability barrier.

35 intaining the selective nuclear pore complex permeability barrier.

36 escued the embryonic lethality and defective permeability barrier.

37 e for a direct involvement in the junctional permeability barrier.

38 t contains unusual lipids and functions as a permeability barrier.

39 rders characterized by an aberrant epidermal permeability barrier.

40 in surface that was paralleled not only by a permeability barrier abnormality but also altered stratu

41 Thus, the baseline permeability barrier abnormality in epidermolytic hyperk

42 ory infiltrate, elevated serum IgE levels, a permeability barrier abnormality, and Staphylococcus aur

43 enomenon] and is associated with a prominent permeability barrier abnormality, excess VEGF production

44 his nature or can promote restoration of the permeability barrier after damage by such agents.

45 Both strains could repair the outer membrane permeability barrier after Mg2+-induced displacement of

46 ne envelops the bacterium and functions as a permeability barrier against antibiotics, detergents, an

47 by lipids and carbohydrates that provides a permeability barrier against hydrophilic drugs and is cr

48 the cell, and the outer membrane serves as a permeability barrier against noxious compounds in the ex

49 late the lamellar body secretory response to permeability barrier alterations, whether modulations in

50 olecular species that subserve the epidermal permeability barrier, an essential function for survival

51 alian cell biology, both through providing a permeability barrier and acting as substrates for synthe

52 ium of mucosal and skin surfaces serves as a permeability barrier and affords mechanisms for local im

53 membrane (OM) of Gram-negative bacteria is a permeability barrier and an intrinsic antibiotic resista

54 ocytosis; perturbation to the outer membrane permeability barrier and hypersensitivity to bile salts

55 the N-terminal domain of Epa1p through this permeability barrier and into the external environment.

56 e of the Gram-negative bacterium serves as a permeability barrier and is composed of lipopolysacchari

57 tive bacteria due to the outer membrane (OM) permeability barrier and multidrug efflux pumps.

58 roles in the integrity of the outer-membrane permeability barrier and participate extensively in host

59 ten consist of tight junctions, which form a permeability barrier and prevent the diffusion of lipids

60 e of Gram-negative bacteria that serves as a permeability barrier and provides rigidity to the cell.

61 prevented the disruption of Sertoli cell TJ permeability barrier and redistribution of TJ proteins (

62 The eukaryotic nuclear permeability barrier and selective nucleocytoplasmic tra

63 hat mummy mutants have a disrupted epidermal permeability barrier and that the nonsense mutation in m

64 90s, it became clear that the outer membrane permeability barrier and the activity of periplasmic bet

65 ss is tuned to promote rapid assembly of the permeability barrier and to generate a stable and compac

66 1, contribute to maintenance of the vascular permeability barrier and to its re-establishment followi

67 trast, the protein compositions of the outer permeability barriers and cytoplasmic membranes were fou

68 of cell-cell adhesion, reduces the monolayer permeability barrier, and compromises cellular contracti

69 epidermis exhibited dry flaky skin, impaired permeability barrier, and enhanced sensitivity to cutane

70 id due to leakage of the brain's microvessel permeability barrier, and swelling of astrocytes as they

71 Membrane permeability barriers are among the factors contributing

72 The PDZ creates a permeability barrier around the crypt restricting immune

73 rhl3), an ancient regulator of the epidermal permeability barrier, as acting downstream of Irf6.

74 ns mediated by drug efflux transporters, and permeability barriers associated with biofilms.

75 eed resealed the Sertoli cell tight junction-permeability barrier based on a functionalin vivoassay i

76 xins would move to sites of breakdown of the permeability barrier because of the calcium-dependent pr

77 Mammalian epidermis provides a permeability barrier between an organism and its environ

78 m-negative bacteria functions as a selective permeability barrier between cell and environment.

79 ions (TJs) create ion-selective paracellular permeability barriers between extracellular compartments

80 on of the outer membrane (OM) as a selective permeability barrier, but how it is established and main

81 affects the major function of epidermis, the permeability barrier, by altering the structure of the s

82 Dysfunction of the epidermal permeability barrier can result in dehydration, electrol

83 rturbed the Sertoli cell tight junction (TJ)-permeability barrier, causing disruption of actin microf

84 against Gram-negative bacteria is due to the permeability barrier conferred by the outer membrane.

85 eficient (Scd2-/-) neonatal mice have a skin permeability barrier defect and a specific repartitionin

86 e postnatally and exhibit a severe epidermal permeability barrier defect, which may originate from ep

87 pla1-deficient neonates die due to epidermal permeability barrier defects with severe transepidermal

88 The nuclear permeability barrier depends on closure of nuclear envel

89 with a spreading disruption of the membrane permeability barrier determined by three-dimensional com

90 Interestingly, the epidermal permeability barrier developed normally during embryogen

91 he PPARdelta ligand, GW 610742X, accelerates permeability barrier development, evidenced by a decreas

92 also accelerates the formation of the SC and permeability barrier development.

93 hat PPARdelta has a role in SC formation and permeability barrier development.

94 respectively) increase 1-8 hours after acute permeability barrier disruption and normalize by 24 hour

95 wn to induce the Sertoli cell tight junction permeability barrier disruption via changes in localizat

96 as infection, injuries, UV irradiation, and permeability barrier disruption) in parallel with induct

97 the calcium gradient disappears after acute permeability barrier disruption, and returns after 6 h i

98 that mirror the lipid metabolic response to permeability barrier disruption.

99 peptide-induced Sertoli cell tight junction-permeability barrier disruption.

100 ine and increased resistance to Hla-mediated permeability barrier disruption.

101 osed mitosis, does not maintain a continuous permeability barrier during mitosis.

102 clinical utility in patients with epithelial permeability barrier dysfunction or who are otherwise at

103 eases, such as epidermal thinning (atrophy), permeability barrier dysfunction, and chronic nonhealing

104 rovokes both a typical scaling phenotype and permeability barrier dysfunction.

105 The epidermal permeability barrier (EPB) prevents organisms from dehyd

106 lamellar layers and giving rise to epidermal permeability barrier (EPB).

107 e formation and maintenance of the epidermal permeability barrier (EPB).

108 of PECAM-1 to support re-establishment of a permeability barrier following disruption with thrombin

109 uperfamily of proteins creating an efficient permeability barrier for antibiotics.

110 eostasis to orchestrate the formation of the permeability barrier for eggshell synthesis during embry

111 Blood-Brain-Barrier (BBB) is a rigorous permeability barrier for maintaining homeostasis of Cent

112 ded that the OM of M. smegmatis represents a permeability barrier for phosphates and that Msp porins

113 negative bacteria is to provide a protective permeability barrier for the cell, and proper maintenanc

114 (Epid)CaR(-/-) mice exhibited a delay in permeability barrier formation during embryonic developm

115 ta activation stimulates differentiation and permeability barrier formation in adults, we hypothesize

116 Defective skin permeability barrier formation in global CGI-58-deficien

117 eratinocytes, a process that is critical for permeability barrier formation.

118 VDR and coactivators in lipid production and permeability barrier formation.

119 o neonatal lethality due to perturbations in permeability barrier formation.

120 ellular junctions (TCJs) are uniquely placed permeability barriers formed at the corners of polarized

121 matic proteins converge to produce defective permeability barrier function and antimicrobial defense

122 re required for maintaining normal epidermal permeability barrier function and biosynthesis of lipids

123 Permeability barrier function and expression of differen

124 Basal permeability barrier function and stratum corneum (SC) i

125 discrete pH changes alone regulate cutaneous permeability barrier function and stratum corneum integr

126 s (urothelial plaques), which play a role in permeability barrier function and uropathogenic bacteria

127 Primary abnormalities in permeability barrier function appear to underlie atopic

128 e are no known gender-related differences in permeability barrier function in adults, estrogens accel

129 erleukin-1 alpha signaling in the decline of permeability barrier function in aged skin, and point to

130 ebum influences stratum corneum hydration or permeability barrier function in asebia J1 and 2 J mice,

131 iated pathological disruption of endothelial permeability barrier function in cells exposed to vascul

132 with darkly pigmented skin display superior permeability barrier function in comparison with humans

133 role of ACh in AMP regulation of immune and permeability barrier function in keratinocytes is review

134 ates for energy metabolism and from impaired permeability barrier function in the skin.

135 Although basal permeability barrier function is established at birth, t

136 ion-fortifying arrangement that enhances the permeability barrier function of the endothelium.

137 The permeability barrier function of the epidermis is one of

138 ations was tested using TEWL to evaluate the permeability barrier function of the epidermis.

139 anes (AUM) that contribute to the remarkable permeability barrier function of the urinary bladder.

140 Although basal permeability barrier function was normal, PPARbeta/delta

141 ed skin, have severely compromised epidermal permeability barrier function, and die within a few hour

142 aled abnormal corneocyte fragility and basal permeability barrier function, but accelerated repair ki

143 lied statins only modestly affects epidermal permeability barrier function, suggesting a possible com

144 ra long-chain ceramides could further impair permeability barrier function, thereby exacerbating the

145 mpeding drug transport across the BTB and TJ permeability barrier function, was not able to induce th

146 r disrupting the Sertoli cell tight junction-permeability barrier function.

147 rneum (SC), which is required for post-natal permeability barrier function.

148 er evidence that AMP expression is linked to permeability barrier function.

149 SC lamellar membranes that are essential for permeability barrier function.

150 (LB) in keratinocytes, which is critical for permeability barrier function.

151 ture of the lamellar membranes that regulate permeability barrier function.

152 nly barrier recovery kinetics but also basal permeability barrier function.

153 sis is carefully controlled to ensure that a permeability barrier has been established before membran

154 idermal VEGF in the maintenance of epidermal permeability barrier homeostasis and a link between epid

155 functional abnormalities, including aberrant permeability barrier homeostasis and decreased stratum c

156 Asebia J1 mice showed normal permeability barrier homeostasis and extracellular lamel

157 intrinsically aged skin displays compromised permeability barrier homeostasis and reduced stratum cor

158 n of neonatal SC results in abnormalities in permeability barrier homeostasis and SC integrity and ar

159 birth, neonatal epidermis displays decreased permeability barrier homeostasis and SC integrity, impro

160 y impacts key epidermal functions, including permeability barrier homeostasis and SC integrity.

161 , as well as decreased CD, compromising both permeability barrier homeostasis and SC integrity.

162 tors correct the functional abnormalities in permeability barrier homeostasis and SC integrity/cohesi

163 e formation of an acidic SC and improve both permeability barrier homeostasis and SC integrity/cohesi

164 ) pH are accompanied by minor alterations in permeability barrier homeostasis and SC integrity/cohesi

165 est that an acidic pH is required for normal permeability barrier homeostasis and SC integrity/cohesi

166 f acidification mechanisms disturb cutaneous permeability barrier homeostasis and stratum corneum int

167 that PAR-2 plays a central role in epidermal permeability barrier homeostasis by mediating signaling

168 receptor (LXR) activation improved epidermal permeability barrier homeostasis by stimulating keratino

169 opical H1/2r antagonists additively enhanced permeability barrier homeostasis in normal mouse skin by

170 Permeability barrier homeostasis is enhanced in SKH2/J v

171 mulate keratinocyte differentiation, improve permeability barrier homeostasis, and accelerate the in

172 idification in adults is required for normal permeability barrier homeostasis, and lipid processing o

173 unction, we studied stratum corneum (SC) pH, permeability barrier homeostasis, and SC integrity in th

174 the importance of SP/SPI balance for normal permeability barrier homeostasis, and second, they ident

175 LXR activation resulted in an improvement in permeability barrier homeostasis, associated with an inc

176 r, epidermal vegf(-/-) mice display abnormal permeability barrier homeostasis, attributable to decrea

177 and impairs keratinocyte differentiation and permeability barrier homeostasis, indicating a key role

178 udies demonstrated PS-induced alterations in permeability barrier homeostasis, mediated by increased

179 enous glucocorticoids (GCs) that compromises permeability barrier homeostasis, stratum corneum cohesi

180 Key functions of the skin including permeability barrier homeostasis, stratum corneum surfac

181 ocyte differentiation and improves epidermal permeability barrier homeostasis.

182 iggered or exacerbated by impaired epidermal permeability barrier homeostasis.

183 r requirements and (2) CRAMP is required for permeability barrier homeostasis.

184 sely, LB-derived AMPs are also important for permeability barrier homeostasis.

185 role for FAK: maintenance of adult epidermal permeability barrier homeostasis.

186 FA2H expression are essential for epidermal permeability barrier homeostasis.

187 ch PPAR and LXR activators promote epidermal permeability barrier homeostasis.

188 synthesis/secretion, which in turn influence permeability barrier homeostasis.

189 nd liver X receptor (LXR) activators improve permeability barrier homeostasis.

190 count for their ability to improve epidermal permeability barrier homeostasis.

191 n, though arguably its most important, i.e., permeability barrier homeostasis.

192 tone treatment, indicating an improvement in permeability barrier homeostasis.

193 lly, topical oxysterol pretreatment improved permeability barrier homeostasis.

194 repletion can have negative consequences for permeability barrier homeostasis.

195 he stratum corneum, where it is critical for permeability barrier homeostasis.

196 /delta in the epidermis: (1) is required for permeability barrier homeostasis; (2) regulates keratino

197 accharide molecule is a major element in the permeability barrier imposed by the outer membrane and o

198 impairment in epidermal differentiation and permeability barrier in (Epid)CaR(-/-) mice maintained o

199 n microscopy revealed a loss of the lamellar permeability barrier in Abca12-/- skin.

200 ter membrane that serves as a very effective permeability barrier in an environment that is poor in d

201 l-CoA synthetase that is required for normal permeability barrier in mammalian skin.

202 it diaphragm are essential components of the permeability barrier in the kidney.

203 al report that EspP L5 helps to maintain the permeability barrier in the outer membrane.

204 first that acute disruption of the epidermal permeability barrier in young mice leads not only to a r

205 Fourth, disruption of the permeability barrier induced similar elevations in epide

206 A permeability barrier initially limits up-dip swarm migra

207 Permeability barrier insults stimulate rapid secretion o

208 hat adherens junctions may regulate vascular permeability barrier integrity and cardiomyocyte functio

209 adhesive strength, epithelial behavior, and permeability barrier integrity.

210 Defective permeability barrier is an important feature of many ski

211 The cutaneous permeability barrier is essential for life and perturbat

212 The loop-gate permeability barrier is formed by a segment of the first

213 A prominent example of such a selective permeability barrier is given by mucus.

214 TR affinity, and the centrally located dense permeability barrier is overcome by multivalent interact

215 um, which play a key role in maintaining the permeability barrier, is reduced in atopic dermatitis an

216 iotactin results in SJ and TCJ breakdown and permeability barrier loss.

217 tion of toxic agents may indicate incomplete permeability barrier maturation in the early neonatal pe

218 3 perturbed the Sertoli cell tight junction-permeability barrier, mediated by changes in the localiz

219 In Sertoli cell cultures with established permeability barrier mimicking the BTB in vivo, the knoc

220 an IM protein involved in maintaining the OM permeability barrier, modulates the rate of PL transport

221 sely filled with FG-nucleoporins that form a permeability barrier of a still-obscure nature.

222 In response to acute disruption of the permeability barrier of aged mammals there is a diminish

223 ntibacterial cargo across the outer membrane permeability barrier of Gram-negative pathogens utilizin

224 The permeability barrier of nuclear pore complexes (NPCs) co

225 structural and functional properties of the permeability barrier of nuclear pore complexes.

226 ne-rich nucleoporins (FG-Nups), which form a permeability barrier of still elusive and highly debated

227 mental importance to life of maintaining the permeability barrier of the cell membrane, it is propose

228 c and lumenal occur without compromising the permeability barrier of the ER membrane.

229 m, is a necessary component of the selective permeability barrier of the kidney glomerulus.

230 h each translocon forms an aqueous pore, the permeability barrier of the membrane is maintained durin

231 ded protein substrates without breaching the permeability barrier of the membrane.

232 The permeability barrier of the OM results partly from the l

233 ts as a ligand-expelled gate to preserve the permeability barrier of the OM.

234 lysaccharide (LPS) contributes to the robust permeability barrier of the outer membrane, preventing e

235 -affinity, cohesive interactions to form the permeability barrier of the pore, although the form and

236 ollowing acute and chronic challenges to the permeability barrier of the skin.

237 enzyme, 12R-LOX, to disruption of the normal permeability barrier of the skin.

238 the source of surface antigens and a primary permeability barrier of the spore, its molecular structu

239 findings suggest that the antimicrobial and permeability barriers of the skin are closely linked.

240 cross cell monolayers without disrupting the permeability barrier or cell viability, and enabled tran

241 d promoted solely by an intrinsic intestinal permeability barrier perturbation, establishes St14 as a

242 ells with an established tight junction (TJ)-permeability barrier perturbed the TJ-barrier via change

243 61 complex also functions to maintain the ER permeability barrier, preventing the mass free flow of e

244 r -incompetent cargo complexes, and then the permeability barrier properties of the droplets were opt

245 We show that the liquid state mimics permeability barrier properties of the physiological nuc

246 A permeability barrier, provided by bed-capping cements th

247 These are the establishment of the permeability barrier, provision of the environment for m

248 ated that cold exposure (4 degrees C) blocks permeability barrier recovery after acute disruption.

249 ions of PAR-2 agonist peptide, SLIGRL, delay permeability barrier recovery and inhibit LB secretion,

250 sociated epidermal functions and accelerates permeability barrier recovery and skin wound healing.

251 The superbases also delayed permeability barrier recovery, attributable to decreased

252 rease in mBD3 protein, CRAMP-/- mice delayed permeability barrier recovery, attributable to defective

253 eceptor 3 has an important role in signaling permeability barrier repair following injury induced by

254 RNA may be another pathway for activation of permeability barrier repair.

255 ease the expression of genes associated with permeability barrier repair.

256 e keratinocyte proliferation; (3) accelerate permeability barrier repair; (4) increase epidermal lipi

257 obial barriers are coordinately regulated by permeability barrier requirements and (2) CRAMP is requi

258 normal hairless mice, a specific response to permeability barrier requirements because up-regulation

259 Thus, permeability barrier requirements coordinately drive bot

260 d production could be coregulated by altered permeability barrier requirements.

261 Artificial permeability barrier restoration, which inhibits the lip

262 Disruption of the permeability barrier stimulates a repair response that l

263 d sphingolipid production and enhancement of permeability barrier structural markers.

264 pithelium, and a "tightened" Sertoli cell TJ permeability barrier, supporting the role of Arp2/3 comp

265 Gram-negative bacteria serves as a selective permeability barrier that allows entry of essential nutr

266 OM) of Gram-negative bacteria is a selective permeability barrier that allows uptake of nutrients whi

267 A selective permeability barrier that arises from a supramolecular a

268 In particular, we reveal a heterogeneous permeability barrier that combines an inner ring barrier

269 This OM presumably acts as a permeability barrier that imparts high levels of intrins

270 PS molecules, the OM behaves as an effective permeability barrier that makes Gram-negative bacteria i

271 lls cultured in vitro with an established TJ permeability barrier that mimicked the BTB in vivo, Cdc4

272 ls isolated from rat testes that formed a TJ-permeability barrier that mimicked the BTB in vivo.

273 Sertoli cell cultures with an established TJ permeability barrier that mimicked the BTB in vivo.

274 itro with an established tight junction (TJ) permeability barrier that mimics the BTB in vivo, the kn

275 ral epithelia, generates an outer protective permeability barrier that prevents water loss, entry of

276 the OM's ability to function as a molecular permeability barrier that protects the bacterium against

277 mmetric outer membrane (OM), which acts as a permeability barrier that protects the cell from externa

278 ontribution of the formidable outer-membrane permeability barrier that reduces the compounds efficacy

279 Occluding-junctions form a permeability barrier that regulates the accessibility of

280 tify PAR-2 as a novel signaling mechanism of permeability barrier, that is, of response linked to LB

281 lthough these bilayers are important for the permeability barrier, the ECM contains not only lipids b

282 s caused by the disruption of the lipid-rich permeability barrier, the innermost layer of the C. eleg

283 Following disruption of the permeability barrier, there is a rapid restoration of ba

284 (Cers) are key constituents of the epidermal permeability barrier, they also function as apoptogenic

285 Skin and bladder epithelia form effective permeability barriers through the activation of distinct

286 ells to grow at 37 degrees C suggests the ER permeability barrier to be compromised in these mutants.

287 lthough transport receptors enable the NPC's permeability barrier to be overcome, directionality is e

288 We hypothesized that the responsible permeability barrier to CO(2) resides in the umbrella ce

289 To test whether the observed permeability barrier to CO(2) was due to an unstirred la

290 of the lipid bilayer in such a way that the permeability barrier to hydrophilic molecules and ions i

291 ctive layer around the cell that serves as a permeability barrier to prevent unrestricted access of n

292 or 4 complex, and acts as a component of the permeability barrier to prevent uptake of bactericidal c

293 A key function of the skin is to provide a permeability barrier to restrict the movement of water,

294 m-negative bacteria functions as a selective permeability barrier to the environment.

295 ts provide evidence for the existence of low-permeability barriers to melt migration within the lower

296 fferentiation, and by function examining the permeability barrier using transepidermal water loss (TE

297 nd electron microscopy demonstrated that the permeability barrier was a distinct envelope that formed

298 As a bottom-up nanoscale model for the permeability barrier, we have used planar films produced

299 of the yeast cell wall is known to act as a permeability barrier; we found that the C-terminal Ser/T

300 ese microorganisms have a highly restrictive permeability barrier, which limits the penetration of mo