ライフサイエンスコーパス: permeability to

1 I alone whereas rutin decreased water vapour permeability to 1.2 g mm/m(2)h kPa.

2 body to JAM-A demonstrated a 33% increase in permeability to 10,000 MWt dextran compared with monolay

3 nfocal Leak Score (CLS; range: 0=no impaired permeability to 100=complete loss of barrier function).

4 nstrated by high TEER values and a selective permeability to [14C] phenytoin and the well-known parac

5 Permeability to 150-kDa FITC-dextran decreased by a litt

6 ance (TCER) greater than 100 ohm cm2 and low permeability to 4 kDa and 20 kDa dextrans.

7 barrier integrity was examined by measuring permeability to 4-kDa fluorescein isothiocyanate-dextran

8 mice had increased in vivo and ex vivo colon permeability to 4-kDa fluorescently labeled dextran and

9 sepithelial electrical resistance [TEER] and permeability to 4-kDa fluorescently labeled dextran or 7

10 n depletion increased diffusive paracellular permeability to 467 Da TAMRA by 15%, and permeability un

11 n protein with siRNA did not alter diffusive permeability to 70 kDa and 10 kDa RITC-dextran, and perm

12 ility to 70 kDa and 10 kDa RITC-dextran, and permeability to 70 kDa dextran was twofold lower in occl

13 d blocked part of the VEGF-induced monolayer permeability to 70-kDa dextran.

14 No significant differences in permeability to 70-kDa FITC-dextran were observed at pre

15 BBB permeability to 70kDa FITC-Dextran was measured 24h foll

16 nd study showed increased alveolar-capillary permeability to a 70-kD fluorescent-labeled dextran only

17 ies such as the need for restricting osmotic permeability to a constant area near the tip, which was

18 Measurements of permeability to a high molecular mass contrast agent (35

19 Dynamic MR imaging revealed microvascular permeability to a high-molecular-weight contrast agent w

20 in-1 in Can 10 clones increased paracellular permeability to a level similar to that of parental cell

21 By contrast, VEGF did not alter BBB permeability to AAV2/5-lacZ, as defined by beta-galactos

22 ndrial dysfunction, inhibiting mitochondrial permeability to ADP and inducing mitochondrial hyperpola

23 y reduced in NRTN(-/-) mice, whereas corneal permeability to AFD was significantly increased.

24 The partition coefficient of permeability to albumin also showed a decline with incre

25 ied by a significant increase in endothelial permeability to albumin and a decrease in hyaluronic aci

26 h ATL313 also blocked the increased podocyte permeability to albumin and disruption of the actin cyto

27 onectin and AMPK activation reduced podocyte permeability to albumin and podocyte dysfunction, as evi

28 Whereas GH increased podocyte permeability to albumin in a paracellular albumin influx

29 ycocalyx depth and increased apparent solute permeability to albumin in the same vessels in a time-de

30 Increased permeability to albumin is a well-known feature of diabe

31 -1a+4_a animals have an increased glomerular permeability to albumin without significant changes in B

32 layed significantly lower levels of vascular permeability to albumin, compared to day 1.

33 adherins in podocytes and increased podocyte permeability to albumin.

34 as hypothesized that differences in membrane permeability to aldopentoses provide a mechanism for pre

35 Corneal permeability to AlexaFluor dextran (AFD; Molecular Probe

36 ate tight junction disruption, promoting BBB permeability to allow bacterial passage.

37 microenvironment triggers selective membrane permeability to allow small molecules (glucose and O(2))

38 ilayer membrane accounts for its much larger permeability to anions than cations and affects the conf

39 the current study were to quantify placental permeability to antipsychotic medications and to documen

40 drial outer membrane (MOM), and modulate its permeability to apoptotic factors, controlling their rel

41 ociated with large increases in membrane Na+ permeability to approximately 80 pA/pF or more.

42 8 to glycine, was sufficient to restore K(+) permeability to AtHKT1.

43 manner and is capable of increasing membrane permeability to ATP at even relatively low concentration

44 Furthermore, PE cells exhibited a decreased permeability to Ba2+ but an increased permeability to Mn

45 ined implant-abutment assembly, the very low permeability to bacteria of the conical implant-abutment

46 Serologic measures of increased intestinal permeability to bacterial components are associated with

47 rn leads to increases in epithelial cellular permeability to bacterial products, leading to endotoxem

48 Determination of compound's permeability to BBB is prerequisite in CNS drug discover

49 ty of any compound with significant membrane permeability to be applied intracellularly by whole-cell

50 d to be directly observed, allowing membrane permeability to be determined easily from the transient

51 riant AQP4 channels reduced normalized water permeability to between 26 and 48% of the reference (P <

52 DL prevented shock-induced increases in lung permeability to both Evans blue dye and protein in addit

53 ression of claudin-5 and blood-brain barrier permeability to both exogenous sodium fluorescein and en

54 ular tracers in the neonates showed that BBB permeability to both large (70 kDa dextran) and small (3

55 as diet-induced insulin resistance increased permeability to both NaFl and Evans blue, which forms a

56 Endothelial cell permeability to both small dye molecules and large lipos

57 er in parallel with defects in microvascular permeability to both water and albumin, in both continuo

58 egulate glycocalyx structure and microvessel permeability to both water and albumin.

59 lyx are critical regulators of microvascular permeability to both water and albumin.

60 eristic of these homomeric ASIC-1as is their permeability to Ca(2+) Activation of ASIC-1a in MNTB neu

61 channel properties, Mg(2+) block, selective permeability to Ca(2+) and single-channel conductance, w

62 e demonstrate for the first time hemichannel permeability to Ca(2+) by measuring Ca(2+) transport thr

63 In addition, a slight permeability to Ca(2+) is detected when palytoxin binds

64 Because alpha7-nAChRs have a high permeability to Ca(2+), we performed TUNEL staining to i

65 The increased membrane permeability to Ca2+ cannot be attributed to activation

66 re the major carriers of current, but finite permeability to Ca2+ leads to a significant intracellula

67 The channel has high permeability to calcium relative to monovalent cations a

68 However, because of their permeability to calcium, GluR2-lacking but not WT AMPARs

69 family of cationic channels with significant permeability to calcium, potassium and sodium.

70 alpha7 gene product and has a high relative permeability to calcium.

71 ce (MprF) virulence factors control cellular permeability to cationic antibiotics by aminoacylating i

72 Furthermore, the outer membrane permeability to cephalothin and cephaloridine, measured

73 hen we change the width of the EUF, membrane permeability to CO(2), native extra- and intracellular c

74 nanoreactors with tumor-pH-tunable membrane permeability to coload H(2)O(2)-responsive prodrug and G

75 that is partly a result of reduced vascular permeability to contrast agents rather than a true antit

76 els also appear to have sufficient HCO(3)(-) permeability to contribute directly to HCO(3)(-) secreti

77 Torsional motility and junctional permeability to dextran are greatly increased in cells e

78 d with a Rho-dependent increase in monolayer permeability to dextrans, suggesting that such functiona

79 potentials showed the relative BzATP-induced permeabilities to different substrates to be Na+, 1 > Cl

80 Permeability to diffusion of fluorescein in a static cha

81 Permeability to diffusion of fluorescein in a static cha

82 lasmodium falciparum have markedly increased permeabilities to diverse organic and inorganic solutes.

83 Malaria parasites increase erythrocyte permeability to diverse solutes including anions, some c

84 This protein increases host cell permeability to diverse solutes.

85 or vessel to the permeability of that vessel permeability to DOX-PLD, indicating that collagen conten

86 Cells also showed immediate increased permeability to doxorubicin with the addition of US + MB

87 lterations of extracellular Ca(2+) and their permeability to dyes and small atomic ions (conductance)

88 are consistent with the known difference in permeability to each molecule.

89 so reduced postischemic blood--brain barrier permeability to endogenous immunoglobulin G.

90 This inhibits potassium permeability to enhance neuronal excitability.

91 rs still suffered from too low cell membrane permeability to enter into CNS drug development.

92 The lptE14 mutation increased OM permeability to erythromycin, even when the wild-type lp

93 ed LptD-LptE14 complexes in the OM decreases permeability to erythromycin.

94 f ATP that within minutes increases membrane permeability to ethidium (Etd(+)) and Ca(2+) by activati

95 Furthermore, AS101 treatment reduced colonic permeability to Evans blue and decreased colonic TUNEL(+

96 supplied by ATO) exhibited greater vascular permeability to Evans blue dye and fluorescein isothiocy

97 ith VEGF completely ablated VEGF-induced BRB permeability to Evans Blue-albumin.

98 o, resulting in tissue collapse and membrane permeability to Evans blue.

99 sms beyond simply increasing plasma membrane permeability to exert their lethal effects.

100 hannels, Ca-A/K channels exhibit the highest permeability to exogenously applied Zn2+.

101 nobacterial diazotrophs that might lower the permeability to extracellular O(2) This membrane propert

102 s termed viroporins, which modulate membrane permeability to facilitate critical steps in a viral lif

103 The chamber permeability to FcMeOH can be tuned by varying printing

104 alyzed at specific times after infection for permeability to fibrin and albumin, quantitation of intr

105 It also led to a significant increase in permeability to FITC dextran.

106 r integrity was further assessed in terms of permeability to FITC dextran.

107 Human transscleral permeability to FITC-albumin (70 kDa) and 70-kDa and 150

108 Permeability to FITC-albumin was decreased by approximat

109 495, increasing NO production, and elevating permeability to FITC-dextran 70 in monolayers of cells e

110 PAF failed to increase permeability to FITC-dextran 70 in monolayers of cells t

111 In both tissues, permeability to FITC-dextran was significantly greater 2

112 28- to 1.31-fold) and decreased paracellular permeability to FITC-Dextran, and this effect was abolis

113 nificantly increased paracellular intestinal permeability to FITC-dextran.

114 ction was determined via functional assay of permeability to FITC-dextran.

115 sepithelial electrical resistance (TEER) and permeability to fluorescein isothiocyanate (FITC)-conjug

116 in levels, serum HMGB1 levels, ileal mucosal permeability to fluorescein isothiocyanate dextran, bact

117 ons in TJ proteins correlated with increased permeability to fluorescein isothiocyanate-dextran molec

118 esistance, a marked decrease in paracellular permeability to fluorescence isothiocyanate-dextran, and

119 monolayers do exhibit increased paracellular permeability to fluorescent dextrans.

120 al resistance that correlated with increased permeability to fluorescently labeled albumin.

121 s, paracellular gap formation, and increased permeability to fluxes of dextran and albumin.

122 ogeneous blood vessel lumen and interstitial permeabilities to generate accurate predictions of tumou

123 onductance G cannot be considered markers of permeability to gliadin peptides.

124 t strategies aimed at controlling epithelial permeability to gluten.

125 lity, whereas Eglp2 and Eglp4 show very high permeability to glycerol and urea.

126 a dramatic perforin-independent increase in permeability to GrzB released by the CTLs.

127 A lower limit of lipid bilayer permeability to H(2)S, P(M,H(2)S) >or = 0.5 +/- 0.4 cm/s

128 e, we determined that the relative capillary permeability to hydrophilic macromolecule tracers is sig

129 ing transepithelial resistance, paracellular permeability to hydrophilic solutes, and the TJ proteins

130 HMPV SH expression resulted in increases in permeability to hygromycin B and alteration of subcellul

131 form a dityrosine network that decreases gut permeability to immune elicitors.

132 zer (with very large membrane pores and high permeability to immunoglobulin light chains) or a conven

133 ial target for biochemical modulation of BTB permeability to increase antineoplastic drug delivery se

134 Thus, it is unclear whether permeability to individually injected exogenous tracers-

135 ed neuronal and synaptic function, increased permeability to inflammatory molecules, disrupted glutam

136 ng and attachment, and minimized endothelial permeability to infused fluorescence dextrans, assessed

137 Permeability to inositol phosphates was assessed by flux

138 The absence of correlation between G and permeability to intact 33-mer or p31-49 did not favor pa

139 e celiac disease, increases in transcellular permeability to intact gliadin peptides might be conside

140 catenin, decrease in resistance, increase in permeability to inulin, and redistribution of occludin a

141 Their transient permeability to ion flow makes possible the rapid detect

142 nt, combined with the lack of sensitivity of permeability to ion type or even ion pairs, led us to qu

143 fected with malaria parasites have increased permeability to ions and nutrients, as mediated by the p

144 nd hydraulic permeability indeed showed that permeability to ions and water significantly decreases w

145 cess requires a membrane with relatively low permeability to ions to minimize energy dissipation.

146 ssion of claudin-5 selectively decreased the permeability to ions.

147 Reduced Cx50 permeability to IP(3) could play a role in regulating ce

148 OsHKT2;4 displayed a high permeability to K(+) compared with that to Na(+) (permea

149 Furthermore, the high permeability to K(+) in OsHKT2;4 supports the hypothesis

150 438, 443, or 446 significantly increased the permeability to K(+) versus Na(+).

151 and A443C mutants showed slightly increased permeability to K(+), Rb(+), and Cs(+), suggesting that

152 e, nonselective cation channel function with permeability to K+ > Na+ >> tetraethylammonium.

153 Human erythrocytes have a low basal permeability to L-glutamate and are not known to have a

154 ude to those of WT, but had altered relative permeability to large anions.

155 oncentration-dependent increases in relative permeability to large cations and changes in Ca2+ permea

156 mark of this dynamic process is an increased permeability to large cations such as N-methyl-D-glucami

157 electivity, low unitary conductance, and low permeability to large cations.

158 g delivery method that can increase vascular permeability to large molecular agents.

159 novel regulation of P2X7R outward and inward permeability to large molecules by Cl-(o) and Na+(o), re

160 olayers had markedly enhanced tight junction permeability to large molecules that could be modeled by

161 es a large inward current and an increase in permeability to large molecules, mediated by the opening

162 lial cells demonstrate enhanced paracellular permeability to large molecules, revealing a potential r

163 train and the extent of cytoplasmic membrane permeability to large molecules.

164 but not ADF, depletion increased epithelial permeability to large molecules.

165 primarily as a result of increased capillary permeability to larger molecules.

166 ndothelial cathepsins, increased endothelial permeability to LDL, and the development of lipid streak

167 The produced gas reduces the water relative permeability to less than 1% and, therefore, significant

168 of the IEB; the addition of 15-HETE restored permeability to levels of control tissues.

169 lective Na(+) conductance with a substantial permeability to Li(+) that is subject to acute regulatio

170 ncreased, to different extents, the relative permeability to Li(+), K(+), Rb(+), and Cs(+).

171 We observe that these channels have high permeability to liquid flow and facilitate the transport

172 reactor with tumor-specific tunable membrane permeability to load both hydrophobic phenylboronic este

173 As) exhibited greater intracellular gaps and permeability to low-density lipoprotein or transmigratin

174 Caco-2 monolayers and increases paracellular permeability to macromolecular FITC-dextran.

175 of penetration enhancers that increase skin permeability to macromolecules (approximately 1-10 kDa)

176 entary approaches in which (i) assessment of permeability to macromolecules of different Stokes radii

177 Platelet-activating factor (PAF) increases permeability to macromolecules via translocation of endo

178 locations to increase endothelial monolayer permeability to macromolecules.

179 AGE-bound RAGE increases endothelial permeability to macromolecules.

180 ty that exhibits considerable plasticity and permeability to macromolecules.

181 arasite Plasmodium falciparum have increased permeabilities to many solutes.

182 illus species are impermeable or exhibit low permeability to many compounds that readily penetrate ge

183 e anion channel (PSAC) increases erythrocyte permeability to many solutes in malaria but has uncertai

184 reased permeability to Ba2+ but an increased permeability to Mn2+ and Gd3+, suggesting that PE is ass

185 did not significantly affect (P > 0.05) its permeability to model, sub-micron sized particles, and t

186 Panx1 is unique in its permeability to molecules up to 1 kDa in size and its re

187 , which has a characteristically low passive permeability to monovalent cations.

188 expression was found to reduce paracellular permeability to monovalent inorganic and organic cations

189 ntamination index values demonstrated higher permeability to most microbes in the cemented group.

190 Recent evidence has linked intestinal permeability to mucosal inflammation, but molecular stud

191 nd correlated with significant reductions in permeability to multiple solutes, consistent with uptake

192 n these families had an increase in membrane permeability to Na and K that is particularly marked at

193 It had equal permeability to Na(+) and K(+), but was less permeable t

194 Its permeability to Na(+), estimated from Goldman-Hodgkin-Ka

195 It may also have a limited permeability to Na+ and the zwitterion taurine.

196 c) lack of desensitization/inactivation, (d) permeability to Na+, and (e) inhibition by Brilliant Blu

197 It has similar permeability to Na+, K+ and Cs+, but the organic monoval

198 The properties of the current (permeability to Na+, K+, TEA+, and Cs+; voltage insensit

199 This indicates decreased paracellular permeability to NaCl but increased permeability to nonel

200 istent with this observation, differences in permeability to natural metabolites have been reported f

201 Basolateral membrane permeability to NH(3) was reduced in CDs from Rhcg(-/-)

202 The permeability to NMDG developed as quickly as the channel

203 Permeability to nonelectrolytes showed that linear-chain

204 acellular permeability to NaCl but increased permeability to nonelectrolytes.

205 EDE increased corneal permeability to OGD and fluorescein and corneal surface

206 lprednisolone or doxycycline reduced corneal permeability to OGD, improved corneal smoothness, and de

207 The switch in membrane permeability to OH(-)/HCO(3)(-) can also be recorded as

208 Corneal permeability to Oregon green dextran (OGD) and sodium fl

209 The weak permeabilities to organic cations were resolved by looki

210 alaria parasites exhibit marked increases in permeability to organic and inorganic solutes.

211 se substrates, such as LRRC8D enhancing VRAC permeability to organic substances like taurine or cispl

212 of small biomolecules that alter the bilayer permeability to other ions can upregulate and downregula

213 ion channel known, H(V)1 shows no detectable permeability to other ions.

214 of the tight-junction protein ZO-1 enhanced permeability to oxalate and mannitol in parallel.

215 e time-dependent increase in transepithelial permeability to paracellular marker inulin.

216 linear relationship was observed between the permeability to PFC-NP and accelerated thrombosis (P = 0

217 These observations suggest that excessive permeability to PFC-NP may indicate prothrombotic risk i

218 Permeability to PFC-NP remained minimal until 12 weeks o

219 -) mice, which lack caveolae, have increased permeability to plasma albumin.

220 The knockout mice exhibited reduced vascular permeability to plasma protein, resulting in chronically

221 Increased microvascular permeability to plasma proteins and neutrophil emigratio

222 fibrin deposition and increased endothelial permeability to plasma proteins.

223 re hypothesized to cause enhanced glomerular permeability to plasma proteins.

224 ride selective, with a small but significant permeability to potassium (PNa+ : PK+ : PCl- = 0 : 0.03

225 ological treatment that alters cell membrane permeability to potassium affected the maintenance and e

226 found that ApoL1 confers chloride-selective permeability to preformed phospholipid vesicles and that

227 e exposure, caspase activation, and membrane permeability to propidium iodide in the absence and pres

228 hoid cell function and intestinal epithelial permeability to protect against allergen sensitization.

229 mesenchymal stem cells to restore epithelial permeability to protein across primary cultures of polar

230 f human MSC restored type II cell epithelial permeability to protein to control levels.

231 increased lung vascular and lung epithelial permeability to protein, and decreased alveolar fluid cl

232 increase in lung endothelial and epithelial permeability to protein, extravascular lung water, and a

233 eficial effect of MSC on alveolar epithelial permeability to protein.

234 and functionally alter the slit diaphragm's permeability to protein.

235 latter including an increase in the passive permeability to proteins, smaller solutes, and water and

236 stat measurements, to estimate paracellular permeability to protons, ammonium and bicarbonate in MDC

237 An increased passive (leak) permeability to protons, together with reduced vacuolar

238 We find effective permeabilities to range from 10(-6) to 10(2) millidarcie

239 al fluid and solute homeostasis, we assessed permeability to rat serum albumin (P(RSA)(s)) in mesente

240 barrier function, as indicated by increased permeability to rose bengal diagnostic dye.

241 ls made of different connexins have distinct permeability to second messengers, which could affect ma

242 ntly, the 2019 deck relies on solubility and permeability to select preferred compounds.

243 microvascular hemorrhage, enhanced vascular permeability to serum albumin, and vasogenic cerebellar

244 Deletion of the ompATb gene reduced permeability to several small water-soluble substances.

245 is accompanied by strongly enhanced membrane permeability to small molecules and a measurable rate of

246 We show that BBB permeability to small molecules increases in Apom(-/-) m

247 parasites have aberrant morphology, reduced permeability to small molecules, and structural instabil

248 The high membrane permeability to small monovalent ions is determined usin

249 FI itself is rejected as an index of permeability to small solutes (cf.

250 and demonstrated that enhanced paracellular permeability to small solutes occurred in the absence of

251 ed open probability and a proposed increased permeability to sodium compared with the longer form.

252 elopment of TEER, and increased paracellular permeability to sodium fluorescein in airway epithelial

253 associated with a reduction in paracellular permeability to sodium, whereas decreased claudin-8 abun

254 ls are transmembrane proteins with selective permeability to specific charged particles.

255 anied by an increase in the transendothelial permeability to substances such as sucrose that are norm

256 l electrical resistance (TEER) and selective permeability to sucrose and phenytoin.

257 Aged rats displayed increased BBB permeability to sucrose in the contralateral hemisphere

258 AT1002 increased in vivo permeability to sugar tracers, whereas scrambled control

259 eded, however, to optimally balance hydrogel permeability to support metabolic activities of encapsul

260 lation of inner mitochondrial membrane (IMM) permeability to sustain ATP production.

261 Diffusive and apparent permeabilities to TAMRA (467 Da), dextran (70 kDa), and

262 g6 abcg20 triple mutant plants had increased permeability to tetrazolium red and decreased suberin co

263 loads in the seed coat resulted in increased permeability to tetrazolium salts and a higher sensitivi

264 ats of gpat5 mutants had a steep increase in permeability to tetrazolium salts compared with wild-typ

265 ation temperatures cause differences in coat permeability to tetrazolium, and mutants with increased

266 deficient cells, which increased their water permeability to that of wild-type cells, corrected their

267 owed that glucagon increased the diffusional permeability to the ammonia analog [(14) C]methylamine (

268 s at the i and i+7 positions and confer cell permeability to the cross-linked peptides.

269 GBM permeability to the electron-dense tracer ferritin was d

270 eakage can be predicted by relating membrane permeability to the fraction of peptide translocated.

271 ytosis of SIgA-CD71 complexes and intestinal permeability to the gliadin 3H-p31-49 peptide were analy

272 enic expression of UT-A1 restores basal urea permeability to the level in wild-type mice but does not

273 Ghrelin treatment restored vascular permeability to the level of shams.

274 Obesity increased BBB permeability to the low molecular weight fluorophore sod

275 FL, it does not significantly affect the BBB permeability to the marker.

276 freely permeable membranes, yielding the NE permeability to the molecules that is at least 2 orders

277 triuretic peptide (ANP) to increase vascular permeability to the plasma protein albumin after an acut

278 d that the vitamin fully prevented increased permeability to the polysaccharide inulin by thrombin in

279 the essential role of ROS and mitochondrial permeability to the process.

280 Implant connection permeability to the studied microorganisms was estimated

281 which may be associated with different tumor permeability to therapeutic agents among patients.

282 Corneal epithelial permeability to three different-sized molecules increase

283 oral effects ranging from increased membrane permeability to toxicity, microinjection of DMSO as a ve

284 treat systemic infections or low intestinal permeability to treat VRE infections in the gastrointest

285 p between transepidermal water loss and skin permeability to tritiated water (3H2O) and the lipophili

286 ancement, and Val-3-HPG exhibited comparable permeability to valacyclovir.

287 These channels shared a similar relative permeability to various anions, but the expressed channe

288 Consistent with this, vascular permeability to vascular endothelial growth factor in mi

289 ffects on intestinal bacteria regulating gut permeability to visceral pathogens.

290 l closure requires an increase in guard cell permeability to water and possibly hydrogen peroxide, th

291 genesis while allowing the induction of high permeability to water and small solutes.

292 J) has a key role in regulating paracellular permeability to water and solutes in the kidney.

293 at could be related to the decreased cuticle permeability to water observed in the regions silencing

294 ons of FJP and CG enhanced the thickness and permeability to water vapor, and made the films more hyd

295 membrane ultrastructure and shows increased permeability to water vapor, demonstrating the importanc

296 extraordinary proton conductivity and super-permeability to water were overlooked.

297 ing angiogenesis while VEGF induces the high permeability to water, characteristic of the glomerular

298 s the air becomes dryer, which decreases its permeability to water, thus counterbalancing the increas

299 titutive surface expression levels and water permeability to wild-type AQP4.

300 d not lead to membrane blebbing or increased permeability to Yo-Pro-1.