コーパス検索結果 (1語後でソート)
通し番号をクリックするとPubMedの該当ページを表示します
1 he barrier imposed by the outer membrane was permeabilized).
2 : (i) alive; (ii) fixed, and (iii) fixed and permeabilized.
3 he parasitophorous vacuole membrane (PVM) is permeabilized 10-30 min before its PKG-triggered breakdo
7 ications that utilize peptides with membrane-permeabilizing activities that are triggered by physiolo
9 e N-terminus of sticholysins can mimic their permeabilizing activity and, together with the full-leng
10 of this system, PopB and PopD, have membrane permeabilizing activity based on previous dye leakage ex
12 erformed a detailed analysis of the membrane permeabilizing activity of Bax and Bak at the single ves
13 hanism is still debated because the membrane permeabilizing activity of ceramide remains poorly under
14 ng of the molecular mechanism underlying the permeabilizing activity of StII(1-30) and peptides or pr
15 ions, we tested the effects of EsxA membrane-permeabilizing activity on mycobacterial virulence and c
16 to mycobacterial virulence with its membrane-permeabilizing activity that is required for cytosolic t
17 However, evidence that link EsxA membrane-permeabilizing activity to Mtb cytosolic translocation a
18 on Q5K significantly diminished the membrane-permeabilizing activity, while Q5V enhanced the activity
20 ssments in the presence of an outer membrane-permeabilizing agent or in efflux-compromised strains in
22 therapies including those based on membrane-permeabilizing agents and nanomaterials as drug carriers
23 factor (VPF), suggesting that other vascular permeabilizing agents, such as histamine and serotonin,
26 ponins, often show a superior performance to permeabilize and lyse membranes and/or a better suitabil
28 ficient actin staining was achieved in fixed permeabilized and non-permeabilized cells using differen
29 nocytochemistry was performed under both non-permeabilized and permeabilized conditions to detect sur
39 residing on the surface of lipid bilayer and permeabilizing bacterial membranes at high concentration
41 ith saponin (plasma membrane and ER membrane permeabilized), BeauIII inhibited SOAT1 (IC50, 1.8 micro
42 a treatment with digitonin (plasma membrane permeabilized), BeauIII selectively inhibited SOAT1 (IC5
48 using cells in which the plasma membrane was permeabilized, but the ciliary membrane was left intact.
51 -PRO-1 dye uptake in CHO-K1 cells which were permeabilized by multiphasic nsEP (600 ns per phase) fro
59 re here the effect of stretch of contracting permeabilized cardiac trabeculae of the rat on the rate
61 , we compared SR Ca(2+) transport in saponin-permeabilized cardiomyocytes before and after limiting S
63 P-C N'-terminal domains (C0-C7) in detergent-permeabilized cardiomyocytes from gene-edited Spy-C mice
65 and contractile behaviour in single membrane-permeabilized cardiomyocytes in human left ventricular h
78 f T. brucei vtRNA impairs mRNA splicing in a permeabilized cell system, suggesting new roles for thes
80 munoprecipitation, CUT&RUN, in which unfixed permeabilized cells are incubated with antibody, followe
81 Considered together, these results establish permeabilized cells as a viable system in which to eluci
82 e complex (NPC) or the actin cytoskeleton in permeabilized cells demonstrated that the ciliary diffus
83 Only 4 of the 5 serum samples reacted to permeabilized cells enough to be distinguished from back
84 lear envelope (NE) was observed in digitonin-permeabilized cells in the absence of cytosolic factors.
90 was achieved in fixed permeabilized and non-permeabilized cells using different combinations of dye
92 and can be applied to isolated mitochondria, permeabilized cells, and tissue homogenates with high se
95 s focused primarily on import pathways using permeabilized cells, it has recently proven feasible to
96 ubiquitination of reductase in membranes of permeabilized cells, leading to enhanced dislocation of
97 enome by small molecular dyes in selectively permeabilized cells, nuclease protection, and flotation
99 lpha/CAS complex assembly and disassembly in permeabilized cells, using single-molecule fluorescence
111 n vitro (isolated mitochondria) and in situ (permeabilized cells/tissue) approaches provide direct ac
113 stem by NaD1 for direct binding of PIP2 that permeabilizes cells via a novel membrane disrupting mech
116 derstanding the concerted action of membrane-permeabilizing compounds in biology as well as for optim
117 s performed under both non-permeabilized and permeabilized conditions to detect surface and intracell
118 ized with GAD on immunohistochemistry and in permeabilized cultured cerebellar GABAergic neurons, as
119 maximal specific calcium-activated force of permeabilized diaphragm fibers were all significantly de
120 nly either a alpha-helical structure able to permeabilize dimyristoylphosphatidylcholine (DMPC) and d
122 e Ca(2+) release evoked by submaximal IP3 in permeabilized DKO1 and DKO2 but was ineffective in DKO3
125 ut heterogeneous tumor vasculature, with the permeabilizing effects of mild (40-42 degrees C) hyperth
126 e Lactobacillus plantarum that is chemically permeabilized enables reactions at high rates, high conv
127 oxygen consumption rate of left ventricular permeabilized fibers after 4 weeks of treatment was redu
131 MCU-mediated mitochondrial calcium uptake in permeabilized fibroblasts but not in isolated mitochondr
136 temperature on mitochondrial respiration in permeabilized heart and red skeletal muscle (RM) fibres
137 lerates the kinetics of force development in permeabilized heart muscle, but its role in vivo is unkn
138 on elucidating the mechanisms by which ESX-1 permeabilizes host membranes and induces the type I IFN
142 ers to elicit exocytosis when streptolysin O-permeabilized human sperm were loaded with inhibitory an
144 s fixed in situ; isolated rat cardiomyocytes permeabilized, incubated with 1 mmol/L Mg2+, and then fi
145 ty of exocytosis to Ca(2+) was documented in permeabilized INS-1 cells cultured in 11 versus 4 mm glu
147 optosis, the mitochondrial outer membrane is permeabilized, leading to the release of cytochrome c th
148 The ability of these 14-mer peptides to permeabilize lipid vesicles therefore appears to be rela
151 teriaceae isolates would become sufficiently permeabilized, making some of their DNA accessible to ad
153 more, adding purified cyclin C to unstressed permeabilized MEF cultures induced complete mitochondria
154 ease the ability of BMF and HRK to bind BAK, permeabilize membranes and induce apoptosis, suggesting
155 Certain antibiotic peptides are thought to permeabilize membranes of pathogens by effects that are
157 f NaD1 has been attributed to its ability to permeabilize membranes; however, the molecular basis of
159 Infection of macrophages with the membrane-permeabilizing microbe Mycobacterium tuberculosis or inf
160 0 known antimicrobial peptides (AMPs), which permeabilize microbial membranes but have diverse sequen
161 mediated by the ability of these peptides to permeabilize microbial membranes via the formation of am
162 anti-apoptotic proteins being sufficient to permeabilize mitochondria isolated from the same cells.
163 components are involved: the arrival of the permeabilizing molecules to the membrane, the efficiency
164 urrent-voltage relationship of basolaterally permeabilized monolayers treated with Epac1 agonist 8-(4
165 aling in situ, by analyzing Ca(2+) sparks in permeabilized mouse cardiomyocytes under a broad range o
166 ortin alpha/beta, and transportin cargoes in permeabilized mouse neurons and HeLa cells, in a manner
167 ignificantly increased oxidative capacity in permeabilized muscle fibers (P-time x treatment < 0.05,
168 itochondrial OXPHOS capacity was measured in permeabilized muscle fibers by high-resolution respirome
170 Mitochondrial respiration was measured in permeabilized muscle fibers with high-resolution respiro
171 mal ADP-stimulated respiration was higher in permeabilized muscle fibers, which may contribute to the
173 of high-resolution respirometry performed in permeabilized muscle fibres prepared from muscle biopsie
174 ulated (State 3) respiration was measured in permeabilized muscle fibres using high-resolution respir
178 s determined by fluorescence measurements in permeabilized myocytes and isolated mitochondria), impai
179 endent fluorescent probe analyses in relaxed permeabilized myocytes corroborated these findings.
180 eitol reduced RyR-mediated SR Ca(2+) leak in permeabilized myocytes from old rabbit hearts to the lev
181 ng fluorescence resonance energy transfer in permeabilized myocytes, we specifically resolved RyR2-bo
182 cellular redox environment were performed in permeabilized myofibers and primary myotubes prepared fr
185 tial, abundance, and respiration assessed in permeabilized myofibers were not significantly altered i
186 fraction pattern analyses of single membrane-permeabilized myofibres showed, upon maximal Ca(2+) acti
189 tibody binding to live, fixed, and fixed and permeabilized neurons were observed, confirming that onl
190 ese inhibitors revealed intracellular PR3 in permeabilized neutrophils and on the surface of activate
191 h DNA by deep sequencing (GRID-seq) of fixed permeabilized nuclei that allows identification of the e
192 ble sites are captured by Tn5 transposase in permeabilized nuclei to permit, within many droplets in
200 Produced by all forms of life, most membrane permeabilizing peptides are used offensively or defensiv
202 d for decades to design or optimize membrane permeabilizing peptides for applications in the laborato
204 w it may be more useful to think of membrane permeabilizing peptides mechanisms as broad regions of a
205 rol the activity and selectivity of membrane-permeabilizing peptides, we screened a peptide library,
208 modulin-dependent protein kinase (CaMKII) in permeabilized phospholamban knockout (PLN-KO) mouse myoc
209 Moreover, sphingosine has been found to permeabilize phospholipid bilayers, giving rise to vesic
210 ctivities, has reduced abilities to bind and permeabilize PIP(2)- and PS-containing membranes and to
213 Previous studies using anti-syntaxin Abs in permeabilized platelets have suggested roles for both sy
214 cent dyes were released at higher rates from permeabilized polymersomes compared to unmodified ones.
215 constitution of this human cTnC variant into permeabilized porcine cardiac muscle preparations signif
216 For comparison, single myosins in relaxed permeabilized porcine papillary muscle fibers indicated
217 nts confirming that amphipathic and membrane-permeabilizing properties of CSA-13 are sufficient to di
221 ion of various substrates and cofactors onto permeabilized rat gastrocnemius muscle fibers, as well a
224 Although alpha(v)beta(3) integrins regulate permeabilizing responses directed by vascular endothelia
225 t actively close the involved pathologically permeabilized retinal artery and normalize the vessel wa
226 Stiffness measurements in single membrane-permeabilized RV cardiomyocytes demonstrated a gradual i
228 -ray diffraction patterns of single membrane-permeabilized skeletal muscle fibers from mice lacking T
229 re, oxygen concentration, and in the case of permeabilized skeletal muscle, the contractile state of
230 n, belonging to a diverse family of membrane-permeabilizing small polypeptides involved in replicatio
231 TPgammaS)-loaded ARF6 (active form) added to permeabilized sperm induces acrosome exocytosis even in
232 used on cTnI as troponin can be exchanged in permeabilized striated muscle cell preparations, and tes
236 2, but not their respective amyloid fibrils, permeabilized synthetic bilayer membranes in vitro.
238 try experiments confirmed that both peptides permeabilize the bacterial cell membrane but suggested s
239 n emerging noninvasive method to temporarily permeabilize the BBB and the "blood-tumor barrier".
242 hibited a significantly stronger capacity to permeabilize the cytoplasmic membrane of Bacillus megate
243 ction was followed by detergent treatment to permeabilize the cytoplasmic membrane, up to 15-fold enh
244 r results demonstrate that it is possible to permeabilize the endothelial cells of the BBB in a contr
245 -generated gasdermin D-N (GSDMD-N), can also permeabilize the mitochondria linking inflammasome activ
246 conformation changes to homooligomerize then permeabilize the mitochondrial outer membrane during apo
247 age or developmental signals, BAX and/or BAK permeabilize the mitochondrial outer membrane, resulting
250 enylarsonium and perfluorobutylsulfonate, to permeabilize the NPCs to naturally impermeable macromole
253 The pro-apoptotic Bcl-2 protein Bax can permeabilize the outer mitochondrial membrane and theref
254 icroneedles (MNs) selectively and painlessly permeabilize the outermost skin layer, allowing otherwis
255 ow concentration of digitonin to selectively permeabilize the plasma membrane of infected cells, we m
258 , or as cancer therapeutics that selectively permeabilize the plasma membranes of malignant cells.
259 conserved C-terminal delta peptide fragments permeabilize the plasma membranes of nucleated cells of
260 efore FISH and use xylenes and detergents to permeabilize the tissue rather than proteinase K, which
261 al barrier could both increase perfusion and permeabilize the tumor, enhancing chemotherapy penetrati
262 ool enriched in chain prenylated isoflavones permeabilized the bacterial membrane within minutes of e
264 ams and that a judiciously chosen surfactant permeabilized the outer membrane and enhanced this effec
266 antimicrobial peptide (CAMP) antibiotic that permeabilizes the bacterial outer membrane (OM) and has
267 However, if the peptide translocates, it permeabilizes the inner vesicles as well, which then sho
269 that mefloquine disrupts lysosomes, directly permeabilizes the lysosome membrane, and releases cathep
270 to most antimicrobial peptides, cWFW neither permeabilizes the membrane nor translocates to the cytop
271 t to the mode of action of OV-3 alone, which permeabilizes the membrane without lipid oxidation.
275 escent dye (carboxyfluorescein), the peptide permeabilizes the outer membrane, and dye enters the out
277 ts in monocyte-derived human macrophages and permeabilizes the plasma membrane to polyatomic cationic
279 that chicken cathelicidin-2 kills E. coli by permeabilizing the bacterial inner membrane and subseque
280 potency of other antibiotics, presumably by permeabilizing the membrane and allowing easier access o
284 e investigated whether ultrasound, which can permeabilize tissue through a phenomenon known as transi
285 sting that passive diffusion into previously permeabilized tissue is the major mechanism for the incr
286 e (temperature-jump of 0.5-20 masculineC) of permeabilized trabeculae over a physiological range of s
287 IP(3) was also able to release Ca(2+) from permeabilized trypanosomes or isolated acidocalcisomes a
288 ochondrial Ca(2+) accumulation in intact and permeabilized trypanosomes, generates excessive mitochon
290 Ca(2+) flux amplitude and SR Ca(2+) load in permeabilized ventricular myocytes as an endogenous cell
291 reticulum (SR) Ca(2+) dynamics in intact and permeabilized ventricular myocytes using confocal micros
293 hibits the ability of preformed oligomers to permeabilize vesicles and induce cytotoxicity in a rat b