ライフサイエンスコーパス: permeation

1 ombination by 40%, while minimizing moisture permeation.

2 necessary for toxin activation and membrane permeation.

3 t differences in the region of ion and lipid permeation.

4 mics, and electrostatics calculations of ion permeation.

5 gate profoundly alters TMEM16F phospholipid permeation.

6 ed by detergent molecules that block solvent permeation.

7 also in acidic or basic compounds with poor permeation.

8 ty of the pore domain, directly blocking ion permeation.

9 eal time, revealing key stages of the atomic permeation.

10 better describes pH-coupled partitioning and permeation.

11 a key role in defining both selectivity and permeation.

12 tation of the bilayers and increase in water permeation.

13 vation of structure-kinetic relationships of permeation.

14 nt partitioning and diffusion to contaminant permeation.

15 the molecular determinants of gating and ion permeation.

16 ectivity filter that may serve as a gate for permeation.

17 ed tissue and to prevent blood-brain barrier permeation.

18 rophobic gating mechanism for control of ion permeation.

19 ns, reduced K(+) affinity, and increased ion permeation.

20 he main barrier of diffusion on percutaneous permeation.

21 tes that W583 is part of the gate for Ca(2+) permeation.

22 ctive layer thickness) that determine solute permeation.

23 es, consistent with its explicit role in ion permeation.

24 hydrophobic DMIMPF(6) layer blocked moisture permeation.

25 s, as this scenario would impair electrolyte permeation.

26 tions in highly conserved motifs affect drug permeation.

27 isms, allowing accurate inferences on gating/permeation.

28 fying hydrophilic and lipophilic pathways of permeation.

29 e cross polymer (HA-CP) vehicle boosted skin permeation.

30 ted dependence on matrix mechanics and water permeation.

31 noparticles and demonstrate mucoadhesion and permeation across an intestinal barrier model in vitro.

32 eration lipid nanocarrier, upsurges the drug permeation across the BBB due to its unique structural p

33 ins to replenish its levels in neurons after permeation across the blood-brain barrier (BBB).

34 Additionally, NCK-10 exhibited limited permeation across the intestinal tract as assessed via a

35 d hydrazinium, consequently facilitating ion permeation across the NaChBac-like filter.

36 ucture/fibrinolysis, using turbidimetric and permeation analyses and confocal and electron microscopy

37 The poor permeation and absorption properties of the most potent

38 Quantitative evaluation of small molecule permeation and accumulation in Gram-negative bacteria is

39 To understand how external pH affects permeation and accumulation of small molecules in E. col

40 more effective (P < 0.05) for improving BBB permeation and brain accumulation of the darunavir paylo

41 to bacterial morphology, and cause membrane permeation and depolarization.

42 e range of laser poration conditions on skin permeation and deposition of OS2966 was tested in vitro

43 ayer amorphous carbon could prove useful for permeation and diffusion barriers in applications such a

44 ion kinetics in vitro, indicating rapid cell permeation and engagement of its PKC target.

45 ral basis for understanding selective proton permeation and gating of this conserved family of proton

46 Our efforts delineating the permeation and gating regions within this complex ion ch

47 an umbilical vein endothelial cell monolayer permeation and is 3.7-fold less lethal to mice by LD(50)

48 ng GPMVs as PM models, particularly for drug permeation and membrane asymmetry.

49 rmeable blood vessels limit the intratumoral permeation and penetration of chemo or nanotherapeutic d

50 with high optical properties, excellent cell permeation and retention, and high stability against che

51 ministered nanoparticles through an enhanced permeation and retention-like effect.

52 ation, they fail to capture the mechanism of permeation and role of water during permeation as seen i

53 We attribute organic solvent permeation and sieving properties to randomly distribute

54 this peptide by investigating model-membrane permeation and structural effects of fragments of the hu

55 o acid transporters (EAATs) mediate chloride permeation and substrate transport.

56 tically compete with the process of membrane permeation and, therefore, inhibit it.

57 veal distinct physical segregation, membrane permeation, and amyloid aggregation processes that are m

58 d diffusion for solvent transport, weak acid permeation, and enzymatic reactions adjacent to membrane

59 ic properties in human, low solubility, weak permeation, and high metabolism, limiting its administra

60 plete atomic-level descriptions for binding, permeation, and subunit interactions at the two major he

61 anism of permeation and role of water during permeation as seen in all-atom simulations.

62 s simulations capturing the kinetic steps of permeation at the atomistic level with a dynamic mechani

63 with a dynamic mechanistic model describing permeation at the in vitro level, finding a high level o

64 llow microneedles can help overcome the skin permeation barrier imposed by the stratum corneum and fa

65 findings are drawn from this study: the main permeation barrier is located in the lipid layers; the f

66 The artery wall is equipped with a water permeation barrier that allows blood to flow at high pre

67 is a unique bilayer that forms an efficient permeation barrier to protect the cell from noxious comp

68 he lipids or corneocytes constitute the main permeation barrier.

69 omal acidification was crucial for O(2) (*-) permeation, because inhibition of the macrophage H(+)-AT

70 citly or explicitly included, we studied the permeation behavior of 2-aminoethoxydiphenyl borate (2-A

71 oral delivery, our understanding of membrane permeation by charged species is limited.

72 Molecular dynamics demonstrates that permeation by dicationic pentamidine is energetically fa

73 with the channel wall, which slows down the permeation by several orders of magnitude.

74 ribed as a 2-fluid system to account for its permeation by the interstitial fluid, and we include flu

75 cations and anions while allowing fast water permeation (ca. 10(9) water molecules per second) on the

76 Ion permeation-changing mutations along the length of TM2 an

77 nalysis of unwashed tissues showed different permeation characteristics depending on each CPA and the

78 final cleanup procedure consisted of (i) gel permeation chromatography (GPC) and adsorption chromatog

79 ely on measuring the molecular weight by gel permeation chromatography (GPC) based on polystyrene mol

80 ical parameter in polymer analysis, with gel permeation chromatography (GPC) being the most common ap

81 X-ray diffraction (XRD), gel permeation chromatography (GPC), and electron paramagnet

82 olyolefin separation techniques, such as gel permeation chromatography (GPC), crystallization elution

83 Analysis by gel permeation chromatography and fluorescence spectroscopy

84 Gel permeation chromatography data for the oxidized lignin s

85 Gel-permeation chromatography with quaternary detection (GPC

86 nthesized and characterized by (1)H NMR, gel permeation chromatography, and differential scanning cal

87 by (1) H and (13) C NMR spectroscopy and gel-permeation chromatography.

88 The analytical technique was based on gel-permeation-chromatography with quadruple detection syste

89 ied by aqueous two- phase extraction and gel permeation column chromatography, and used as a reducing

90 ents are drawn tightly together to block ion permeation completely.

91 pillaries with little resistance, whereas no permeation could be detected even for such small ions as

92 nd desalination technologies is limited by a permeation cutoff of approximately 9 A, which is larger

93 Analysis of permeation data suggests that the ultrahigh selectivitie

94 their mechanisms and energetics of membrane permeation differ slightly.

95 arable gold nanoparticles (AuNPs) affect the permeation, distribution, and retention of the anticance

96 by administration in a carrier with chemical permeation enhancer (CPE) properties.

97 olymer conjugation process that co-localizes permeation enhancer with the protein.

98 ility of 1-phenylpiperazine as an intestinal permeation enhancer, we synthesized protein-polymer conj

99 Chemical permeation enhancers (CPEs) are molecules that interact

100 Although chemical permeation enhancers can improve macromolecular transpor

101 ess low permeability in transdermal patches, permeation enhancers such as alkanols, fatty acids, prod

102 The CG parameters of permeation enhancers were also developed.

103 This permeation-enhancing effect is a function of nanoparticl

104 The permeation-enhancing effect of the nanoparticles was rev

105 Hydrogen shows noticeable permeation, even though its molecule is larger than heli

106 rate constants determining each step in the permeation event allows derivation of structure-kinetic

107 r performing free energy calculations of the permeation event.

108 cular dynamics simulations, and the observed permeation events are in agreement with the anion select

109 Most of the K(+) permeation events observed in hERG1-WT simulations occur

110 determined temporal channel radius profiles, permeation events, and potential of mean force profiles

111 proton conduction, as confirmed by hydrogen permeation experiment, remarkable hydration behavior and

112 Water permeation experiments show that changes are localized t

113 robe the structural determinants of membrane permeation, finding that the desolvation/loss of hydroge

114 er of relevance: selectivity, capacity (i.e. permeation flow rate per unit area) and transport of mas

115 The permeation flux and thus the eluent concentration is con

116 formation on the NF membrane coupon (without permeation flux) was observed by the salinity-stressed b

117 interface, which dramatically influences the permeation free energy landscape and explains why the co

118 c lattice crucially defines the direction of permeation from concave to convex side due to a differen

119 conditions, although their mechanisms of ion permeation gating are not well understood.

120 ramework for understanding mechanisms of ion permeation, gating and channelopathy of cyclic-nucleotid

121 depends both on how well CFTR channels work (permeation/gating) and on how many are present at the me

122 The data suggest that TRPC5 ion channel permeation has little or no effect on atherosclerosis or

123 date, applications of non-cancerous enhanced permeation have been relatively unexploited as target ti

124 The Mo layer likely hinders O2 gas permeation, impeding contact with active Pt.

125 To probe protonation-coupled permeation in atomic detail, we herein apply continuous

126 Although the mechanism of proton permeation in Hv1 remains to be elucidated, a series of

127 involve two gates that appear to prevent ion permeation in the absence of activators: the ion selecti

128 nd the interdependence of channel gating and permeation in the context of such restricted extracellul

129 ns modulate two restrictions controlling ion permeation, including widening of the selectivity filter

130 ur observations indicate that size-dependent permeation into the lamina densa of the GBM and the podo

131 ligoclusters of gold nanoparticles show that permeation into the lamina densa of the GBM is size-sens

132 ostructured electrodes hinders the analyte's permeation into the nanostructured volume and limits its

133 tensive washing, leading to improved protein permeation into the tissue.

134 Key to proton permeation is a methionine residue that interrupts the s

135 A quantitative and thorough study of skin permeation is essential for chemical exposure assessment

136 rly swollen, the lamina densa is absent, and permeation is increased.

137 Predicting permeation is more complex, given passive and carrier tr

138 A "leapfrog" mechanism for ethanol permeation is proposed which is associated with its role

139 ion of a desorbed DNA probe suggest that DNA permeation is severely limited for higher EFs.

140 Moreover, these new insights in aquaporin permeation may allow the pharmacological exploitation of

141 orters are known to be relevant, but passive permeation may also be involved.

142 a high level of agreement with experimental permeation measurements.

143 The results support an accessible passive permeation mechanism for most compounds, including monol

144 ation gate can help elucidate the gating and permeation mechanism of TMEM16 CaPLSases and channels.

145 devices such as oxidation catalysts, oxygen permeation membranes, and solid oxide fuel cells.

146 We also investigated how passive permeation might influence the uptake kinetics into cell

147 stimate the likelihood of poor absorption or permeation, noting the impact of poor solubility.

148 hanism of membrane disruption in which water permeation occurred through lipid-stabilized pores media

149 riments is that GPMVs are sealed, i.e., that permeation occurs by diffusion through the hydrophobic c

150 elevated PCO2 of 55 mmHg greatly delayed the permeation of a fluorescent glucose analogue (NBDG) betw

151 along with free energy sampling to study the permeation of a weak base propranolol (PPL), and evaluat

152 icity based on K(mem/w), which considers the permeation of both neutral and anionic species.

153 ts membrane structure causing uncontrollable permeation of Ca(2+) ions.

154 impermeable to IP(3), while exhibiting high permeation of Ca(2+).

155 selectivity for anions, others supported the permeation of cations and anions at similar rates or eve

156 at similar rates or even allowed the faster permeation of cations.

157 ergy landscape depicts a low barrier for the permeation of cytochrome C into the Bax C-terminal mouth

158 This process, occurring by direct permeation of D-serine through hemichannels or indirectl

159 molecules to cell-derived membranes and the permeation of drug-like molecules through them.

160 inted 3D-muPAD that enables more homogeneous permeation of fluids along the cellulose matrix than oth

161 olecular dynamics simulations of the passive permeation of Hg(II) and [CH3Hg(II)](+) complexes with t

162 of NaVAb/1-226 as an open state that allows permeation of hydrated Na(+), and these results also sup

163 hannels, thereby providing a pathway for the permeation of hydrophilic species.

164 to investigate pH-dependent cytotoxicity and permeation of IOCs across cultured epithelia using ultra

165 nation state may play a critical role in the permeation of ionizable molecules, including pharmaceuti

166 role of possible pore-lining residues in the permeation of ions and ethidium through Cx30 hemichannel

167 capable of discerning (but did not observe) permeation of just a few helium atoms per hour, and this

168 of P2X receptors is wide enough to allow the permeation of large organic cations, including natural o

169 membrane, which is particularly resistant to permeation of many toxic compounds, including antibiotic

170 This subsequently facilitates permeation of medicines into the dermal microcirculation

171 ield across it, we are able to elucidate the permeation of molecules and their mechanism of transport

172 ed on understanding the rules that guide the permeation of molecules into bacteria and on advances in

173 The permeation of most antibiotics through the outer membran

174 te that the molecular motions leading to the permeation of NMDG(+) are very similar to those that dri

175 strom) microstructures that allow for facile permeation of organic solvents and selection between sim

176 stribution, yet the mechanisms for selective permeation of potentially toxic Cu(+) ions across cell m

177 enhanced cellular uptake and transepithelial permeation of QC, which was related to the much-enhanced

178 function of the epidermis impedes effective permeation of siRNA into the skin.

179 ing of Slo2.1 or Slo2.2, suggesting that ion permeation of Slo2 channels is not predominantly gated b

180 Passive membrane permeation of small molecules is essential to achieve th

181 e the opening of the pore domain and ensuing permeation of sodium ions.

182 Permeation of some IOCs from OSPW was mediated by active

183 t catalepsy studies confirmed the restricted permeation of the conjugate through the BBB in vivo.

184 tailed molecular dynamics simulations of the permeation of the lethal factor (LF) N-terminal segment

185 neutral permeabilities suggest that also the permeation of the neutral species should be significant

186 ve voiding symptoms and pain by allowing the permeation of urinary K(+) into suburothelial tissues, w

187 create artificial structures that allow fast permeation of water but reject even the smallest hydrate

188 the determinants that govern the binding and permeation of zwitterionic antibiotics in porin channels

189 ave the smallest size and exhibited the best permeation parameters across the skin.

190 its wall that simultaneously lines the anion permeation path (global); and repacking of a cluster of

191 g, and a bundle of acyl chains occluding the permeation path above the L105 cuff.

192 Opening of the anion permeation path in this iChS is controlled by the elevat

193 dge network, resulting in a reshaping of the permeation pathway and a significant increase in hydroge

194 The reentrant loop lines the lower ion permeation pathway and buttresses the 'Gly-Ala-Ser' (GAS

195 map, localized throughout the intercellular permeation pathway and contributing to the channel archi

196 xplained by the activation of a nonselective permeation pathway by the P2X7 receptor, a phenomenon ca

197 We show how the permeation pathway changes upon channel opening and iden

198 A potential permeation pathway for chloride intersects with the glut

199 periments revealed that SNAT7 is the primary permeation pathway for glutamine across the lysosomal me

200 tify water-accessible residues that line the permeation pathway in transmembrane segment 11 (TM11).

201 on of these mutations indicates that the ion permeation pathway lies between the core and gate ring o

202 als similar constrictions in the central ion permeation pathway near the intracellular end of the S6

203 ion further affects the thermodynamic of the permeation pathway of 2-APB, leading to different entrop

204 roscopy structure of chicken Slo2.2, the ion permeation pathway of the channel is closed by a constri

205 ng, wherein five threonine residues line the permeation pathway of the pentameric receptor channel.

206 in which ions are stably trapped within the permeation pathway of the protein by internal and extern

207 py structure of Slo2.2 suggests that the ion permeation pathway of these channels is closed by a sing

208 and I612, in the middle of the phospholipid permeation pathway of TMEM16F-CaPLSase.

209 e center of three anion binding sites in the permeation pathway S(cen).

210 s detailed molecular insight into the Ca(2+) permeation pathway that can be extrapolated to other Ca(

211 al unwinding of TM5, which together create a permeation pathway that enables substrate and ion diffus

212 nsory neurons results in opening of a cation permeation pathway that triggers the sensation of pain.

213 assium channels, a main component of the ion permeation pathway, configures a stack of binding sites

214 hemical structures, and we delineate the ion permeation pathway, including the contribution of lipids

215 e consistent with binding on the axis of the permeation pathway, similar to classical open channel bl

216 membrane, giving a state with a closed lipid permeation pathway.

217 an alteration of electrostatic field in the permeation pathway.

218 e roles of charged residues in each putative permeation pathway.

219 t TRPV1 channels have two gates within their permeation pathway: one formed by a 'bundle-crossing' at

220 ffinity ATP analogues, suggesting intact ion permeation pathways and nucleotide binding domains (NBDs

221 s open and close, or gate their phospholipid permeation pathways remains unclear.

222 e receptor type 4, and the identification of permeation pathways through the dermicidin antimicrobial

223 trafficking, block the establishment of new permeation pathways, and cause ER expansion.

224 These structures reveal the ion permeation pore and represent different functional state

225 ns to alpha helices, disulfide bonds, or the permeation pore.

226 eam acts as a cytosolic plug that limits ion permeation possibly by clogging the inner vestibule of b

227 To test the passive permeation potential of these phenolics, we performed mo

228 terminal chain is unstructured and leads the permeation process for the LF protein.

229 s are found to play an important role in the permeation process.

230 al advantages, we have demonstrated that the permeation properties of the hollow fiber membrane can b

231 is demonstrated by showing that the original permeation properties of the VPLT-LIPS membranes can be

232 e oxide membranes show exceptional molecular permeation properties, with promise for many application

233 lators bound within the cavity to also alter permeation properties.

234 pedes detailed study of their gating and ion permeation properties.

235 transmembrane cavity impacts both gating and permeation properties.

236 ddition of an anchor region has no effect on permeation properties.

237 ndensed, highly crosslinked ECM impeded drug permeation, protecting tumor cells from exposure to smal

238 to independently determine the total mercury permeation rate from the permeation tubes.

239 ement devices to within 25% when the mercury permeation rate was relatively high (up to 30 pg s(-1)),

240 the droplets was imaged as a function of the permeation rate, J, droplet radius, R, membrane permeanc

241 Importantly, permeation rates decrease exponentially with decreasing

242 Permeation rates derived from the gravimetric method mat

243 ived from the gravimetric method matched the permeation rates observed via mercury measurement device

244 The permeation rates through these mutants are slightly lowe

245 (-1)), but the agreement decreased for lower permeation rates, probably because of increased uncertai

246 f drugs into the cell, little is known about permeation rates, transport pathways and accumulation at

247 channel (and the varphi clamp), the initial permeation represents a critical step, which can be irre

248 The control of ion channel permeation requires the modulation of energetic barriers

249 CMS permeation results with CO(2) /CH(4) (50:50) mixed gas f

250 particles impact the targeting-clearance and permeation-retention paradoxes in the anticancer-drug de

251 These studies reveal the mechanisms of permeation, selectivity and gating and lay the groundwor

252 In potassium (K(+)) channels, permeation, selectivity, and gating at the selectivity f

253 Ex vivo permeation studies in rat intestine showed that formatio

254 Barrier function and bacterial permeation studies that have been performed in primary h

255 t drug recovery was carried out, followed by permeation studies using 350 mum thick neonatal porcine

256 Additionally, ex vivo human skin permeation studies using confocal microscopy revealed th

257 In vitro permeation studies with Caco-2 cells confirmed the trans

258 pe of the in-vivo BBB, particularly for drug permeation studies.

259 channels showed a sharp size cut-off for ion permeation, such that no ion possessing a methyl group w

260 uantitative ITEX method, two laboratory-made permeation systems (for standard VOCs and ISTD) were con

261 ates receptor-toxin interaction and membrane permeation, TcB and TcC form a toxin-encapsulating cocoo

262 The in vitro permeation test (IVPT) has been widely used to character

263 guidance recommends conducting in vitro skin permeation tests (IVPTs) to help select formulations for

264 posable sorbents, and (iv) automatic dynamic permeation tests mimicking transdermal measurements in F

265 The Caco-2 cell monolayer permeation tests showed that PG-QC formulations resulted

266 f any, atomic-scale defects, as shown by gas permeation tests, and place them to separate reservoirs

267 uptake and up to 8.99-fold higher darunavir permeation than free darunavir.

268 Compatible with ATP permeation, the transmembrane pore and cytoplasmic vesti

269 ustrated using two biophysical examples: ion permeation through a phospholipid membrane and protein t

270 molecular dynamics simulations, to study ion permeation through a potassium channel MthK, for various

271 Furthermore, water permeation through aquaporin-1 mediates the EV deformabi

272 contributions of presynaptic release and its permeation through Ca(2+)- (and Zn(2+))-permeable AMPA c

273 However, the atomistic mechanisms of permeation through defects in the graphenic lattice are

274 es the postsynaptic afferent by altering ion permeation through hyperpolarization-activated cyclic nu

275 ized the postsynaptic neuron by altering ion permeation through hyperpolarization-activated cyclic nu

276 , dynamically altering the driving force and permeation through ion channels facing the synaptic clef

277 P2's unique architecture permits pentamidine permeation through its central pore and show how specifi

278 Spontaneous solute and solvent permeation through membranes is of vital importance to h

279 xperiments(1,9,10) that could not detect gas permeation through micrometre-size membranes within a de

280 l dynamics relevant to hydrophobic substrate permeation through molecular-dynamics simulations and by

281 The findings indicate that Ca(2+) permeation through Na(V) channels provides a submillisec

282 size graphene-based sensor to measure oxygen permeation through pulmonary membranes.

283 oss of some water molecules facilitated K(+) permeation through the collar.

284 By restricting water permeation through the droplet interface, the size of th

285 Ion permeation through the extracellular vestibule and the t

286 ork unravels molecular details of fosfomycin permeation through the outer membrane porin OmpF of E. c

287 anning paths for a rapid and selective water permeation through water-wire networks.

288 ery system must aid in both localization and permeation to achieve systemic drug uptake.

289 We attribute the fast proton permeation to ~5- angstrom-wide tubular channels that pe

290 e the total mercury permeation rate from the permeation tubes.

291 py (EIS) that directly probes changes in ion permeation upon chlorination at different pH values, foc

292 enotypic consequences of non-specific sodium permeation via calcium channels remain unknown.

293 Inhibition of TRPC5 ion permeation was achieved by conditional transgenic expres

294 luences of 35.1 J/cm(2), skin deposition and permeation were statistically superior to passive delive

295 ments are not feasible, as well as long-time permeation, where ex vivo samples deteriorate, and thus

296 promote a significant increase in oxygen gas permeation which may bear significance for alveoli gas e

297 vertical interlayer spacing allows for water permeation while perfectly excluding salt, on both the f

298 itiated collagen degradation, prevents water permeation within hybrid layers, and kills bacteria on d

299 ic pores can produce an energetic barrier to permeation without requiring steric occlusion of the pat

300 l form an energetic barrier to water and ion permeation without steric occlusion of the pore.