ライフサイエンスコーパス: permute

1 d PERMutation Using Transposase Engineering (PERMUTE).

2 alternative schemes in which the colors are permuted.

3 mong peptides where amino-acids are randomly permuted.

4 (CE4s) with the canonical motifs circularly permuted.

5 First, circularly permuting 3' of the template causes specific defects in

6 er rate than the mutation model expectation (permuted 95% confidence interval: 1-10 genes; permuted P

7 tility, we use the telomerator to circularly permute a synthetic yeast chromosome originally construc

8 ts in virion chromosomes that are circularly permuted and about 13% terminally redundant.

9 or, referred to as an active optical mapper, permutes and maps the light datacube voxels onto sensor

10 uridine (U51) in the P4 helix of circularly permuted Bacillus subtilis P RNA with 4-thiouridine, 4-d

11 s formed by the two homologs with circularly permuted binding sites showed significant dynamic differ

12 Patients were randomly assigned (2:1; permuted block [block size of six] with an interactive v

13 s were randomly assigned (1:1) by means of a permuted block algorithm (block size of four) via an int

14 s prepared by the study statistician using a permuted block algorithm within each stratum with random

15 tatus (0 vs 1) were randomly assigned with a permuted block allocation scheme via a web response syst

16 tervention or no intervention groups using a permuted block approach stratified by centre.

17 were randomly assigned (1:1) according to a permuted block design (block size 4) via interactive res

18 therapy and randomised (1:1) with a complete permuted block design (block size of four) to either tiv

19 ractive voice and web response system with a permuted block design (block size of four), to receive a

20 Randomisation was based on a randomly permuted block design (block sizes 2 and 4), stratified

21 gestational age at randomisation day with a permuted block design (block sizes 4 and 8).

22 eb-based system, in a 1:1 ratio, with random permuted block design [block size 2, 4, or 6], stratifie

23 s were randomly assigned (1:1) with a random permuted block design to either daily oral estriol (8 mg

24 The randomisation schedule used a randomly permuted block design with block sizes 2 and 4, stratifi

25 m, stratified by clinical centre in a random permuted block design with block sizes of two, four, and

26 ntral interactive web response system with a permuted block design with four patients per block to re

27 and opioid use severity and used a web-based permuted block design with random equally weighted block

28 ned (2:1) to intervention or control using a permuted block design, stratified by age (<10 years and

29 on schedule, stratified by centre and with a permuted block design, to receive either latanoprost 0.0

30 ial of 61 adolescent girls with PTSD using a permuted block design.

31 -generated randomisation lists with randomly permuted block lengths stratified by centre.

32 atients were randomly assigned (1:1) using a permuted block method (block size of four) and an intera

33 and patients were randomly assigned using a permuted block method (block size of four) in a 1:1 rati

34 atients were randomly assigned (2:1) using a permuted block method (block size of six patients) to re

35 located (1:1) by a computer-generated random permuted block method (block sizes 4-8) to either 5 year

36 ion was done centrally by computer-generated permuted block method (variable block size of six or nin

37 articipants were randomized using a randomly permuted block method stratified by baseline 6-minute wa

38 an interactive voice response system by the permuted block method using block size 4 to ipilimumab 1

39 by an independent randomisation team by the permuted block method with a fixed block size of 16.

40 l region and ECOG performance status, with a permuted block method) to receive panitumumab (6 mg/kg o

41 allocated (1:1, stratified by centre with a permuted block method) to receive standard treatment (in

42 and cause of liver disease with a stratified permuted block method.

43 Randomisation was done with use of the permuted block methods (block size of 15 patients) and F

44 gh a central interactive voice system with a permuted block procedure stratified by disease status, a

45 ed (1:1) eligible patients, using a randomly permuted block procedure with variable block sizes and d

46 gned with a computer-generated sequence with permuted block randomisation (1:1) using a centralised i

47 icipants were randomly assigned by web-based permuted block randomisation (block size 4) in a 1:1:1:1

48 randomly assigned 1:1 by computer-generated permuted block randomisation (block size four) list to r

49 mg or docetaxel 75 mg/m(2) every 3 weeks by permuted block randomisation (block size of eight) via a

50 and height were randomly assigned (1:1), via permuted block randomisation (block size of four) using

51 ndomly assigned (1:1) via computer-generated permuted block randomisation (block size of four), with

52 interactive voice-web response system using permuted block randomisation (block size of two) and str

53 Permuted block randomisation (block size six) was done w

54 Permuted block randomisation (block size six; 1:1:1) was

55 misation with sequence generation defined by permuted block randomisation (block size two) was used t

56 patients were randomly assigned (1:1) using permuted block randomisation (block sizes of 2 and 4) an

57 Permuted block randomisation (size four) was done with a

58 The infants were randomly assigned by permuted block randomisation (through the use of a compu

59 s of therapy, and randomly assigned (1:1) by permuted block randomisation (with a block size of four)

60 Permuted block randomisation (with variable block size)

61 teractive voice and web response system with permuted block randomisation in blocks of six to receive

62 n patients (1:1) based on a fixed stratified permuted block randomisation list (block size 4) to rece

63 al biostatistician used a computer-generated permuted block randomisation method, stratified by treat

64 Randomisation was done with permuted block randomisation methods, stratified by radi

65 domisation centre, with a central stratified permuted block randomisation procedure.

66 ents were randomly assigned centrally with a permuted block randomisation schedule.

67 n via an interactive response system under a permuted block randomisation scheme (block size of four)

68 an interactive voice-response system with a permuted block randomisation scheme (block size of ten),

69 every 21 days) or physician's choice using a permuted block randomisation scheme by an interactive vo

70 assignment was made via computer-generated, permuted block randomisation stratified by antiretrovira

71 were randomly assigned in a 1:1 ratio and by permuted block randomisation to receive D-VMP or VMP.

72 Participants were randomly assigned (1:1) by permuted block randomisation to receive either maraviroc

73 ndomly assigned (1:1) via computer-generated permuted block randomisation to rifampicin 300 mg twice

74 ligible patients were randomly assigned with permuted block randomisation using an interactive web re

75 Permuted block randomisation was done separately for par

76 Permuted block randomisation was done with a block size

77 Permuted block randomisation was done with an interactiv

78 immunomodulatory drugs (yes or no), and used permuted block randomisation with a block size of four.

79 ns) or no radiotherapy by computer-generated permuted block randomisation, stratified by centre, with

80 A permuted block randomisation, stratified by geographic r

81 system in a country-by-country scheme using permuted block randomisation, stratified by presence of

82 r delayed antiretroviral treatment by use of permuted block randomisation, stratified by site.

83 We used permuted block randomisation, stratified by world region

84 Randomisation was done by computer-generated permuted block randomisation, with a block size of six.

85 either lenalidomide or placebo groups using permuted block randomisation, with a fixed block size of

86 tion was concealed by blinded block size and permuted block randomisation.

87 year in a 1:1 ratio using computer-generated permuted block randomisation.

88 al treatment group was by computer-generated permuted block randomisation.

89 ystem or interactive web response system and permuted block randomisation.

90 d for each participating clinical site using permuted block randomisation.

91 A permuted block randomised design was adopted for both ra

92 We used a computer-generated permuted block randomization sequence for treatment allo

93 onsenting women within ART groups, using 1:1 permuted block randomization stratified by ART use, age

94 ent interactive voice response system with a permuted block schedule (block size four) without strati

95 an interactive voice response system with a permuted block schedule (block size of six) and stratifi

96 stratum, then randomly assigned (1:1) via a permuted block schedule (size ten), to receive intermitt

97 active voice and web response system using a permuted block scheme (block size of six) and was strati

98 Randomisation was stratified with a permuted block scheme by region, previous eribulin, and

99 the SAPIEN 3 with a computer-based randomly permuted block scheme, stratified by study centre and So

100 Randomisation was internet-based using permuted block sequences.

101 omisation was computer generated with random permuted block size 2 and 4, and allocation was conceale

102 placebo for 45 days, in a 1:1 ratio, with a permuted block size of 10.

103 s achieved by randomly generated codes, with permuted block size of 30, and was stratified by study s

104 ter-generated randomisation sequence (random permuted block size of 6, without stratification or matc

105 transplantation were randomly assigned (2:1; permuted block size of 6; stratified by response to prev

106 (by an independent nurse, in 1:1 ratio, with permuted block size of four and six, using a centralised

107 em, we randomly assigned (2:1) patients in a permuted block size of six to receive lenalidomide (25 m

108 tified by platinum-free interval, and with a permuted block size of six.

109 omputer-generated list with randomly varying permuted block sizes accessed through a validated web-ba

110 concealed randomisation schedules, each with permuted block sizes of 4, were used for randomisation,

111 modulators only vs both therapies), and used permuted block sizes of four and institutional balancing

112 ssigned (1:1), by a computerised system with permuted block sizes of four or six, to receive cognitiv

113 erised programme to randomly assign women in permuted block sizes of four, with groups stratified by

114 ing a computer-generated randomisation list (permuted block sizes of six and 12).

115 ndomisation was done with computer-generated permuted block sizes of six and nine, stratified by cent

116 n interactive response system using randomly permuted block sizes of six and stratified according to

117 according to a block randomisation schedule (permuted block sizes of six or ten).

118 alone, stratified by country and clinic, in permuted block sizes of ten.

119 em after successful screening using randomly permuted block sizes of two and four and stratified by e

120 Randomisation was done with permuted block sizes of two, four, and six, and was stra

121 ned (1:1, stratified by centre with randomly permuted block sizes) 451 patients with recent transient

122 g-on and drug-off conditions in a randomized permuted block study to assess the accuracy of diagnosti

123 ital (MGH) Clinical Research Pharmacy with a permuted-block algorithm, stratified by sex with a fixed

124 ystem and a centralised, computer-generated, permuted-block design of block size six.

125 We used permuted-block randomisation (block size four) to assign

126 A permuted-block randomisation (block size of 4) was appli

127 icipants were randomly assigned (1:1:1), via permuted-block randomisation (block size of six) impleme

128 her randomised (2:1), via computer-generated permuted-block randomisation (block size of six), to rec

129 mly assigned (1:1:1), via computer-generated permuted-block randomisation (block sizes of three, six,

130 y Ionis Biometrics or external vendor with a permuted-block randomisation method.

131 ation and Medication Ordering System) with a permuted-block randomisation schedule (block size of thr

132 native backbone regimen), using a web-based, permuted-block randomisation stratified by gestational a

133 We used computer-based permuted-block randomisation with block sizes of four, s

134 Many multicenter clinical trials use permuted-block randomization to create balanced treatmen

135 We used computer-based permuted-block randomization with block sizes of three o

136 d the randomisation on a computer-generated, permuted-block schedule stratified by use of methotrexat

137 Treatments were assigned based on a permuted blocked randomisation scheme with a block size

138 ited, centrally randomly assigned (1:1) with permuted blocks (block size 4), and stratified by previo

139 ystem, was stratified by site using randomly permuted blocks (block size 7), and the sizes of the blo

140 were randomly assigned (1:1) centrally using permuted blocks (block size 8) to receive cabazitaxel pl

141 ), via computer-generated randomisation with permuted blocks (block size of five), to receive either

142 Randomisation was by stratified permuted blocks (block size of four) using an interactiv

143 Randomisation was done using randomly permuted blocks (block size of four).

144 r-generated randomisation code with balanced permuted blocks (block size of seven) and stratified by

145 We used permuted blocks (block size of six) within each stratum.

146 py or supportive counselling with randomised permuted blocks (block size randomly varying between two

147 tified by ulcer duration and ulcer area with permuted blocks (block sizes four and six).

148 Computer-generated random permuted blocks (mixed sizes of six and nine) were used

149 ) by computerised central randomisation with permuted blocks (size four and six), stratified by centr

150 ), via computer-generated randomisation with permuted blocks (sizes of four to six), to receive socia

151 tician-generated allocation sequence using a permuted blocks algorithm (block size of 4), stratified

152 ndomisation lists were generated with random permuted blocks and stratified by centre and extent of i

153 mg AMG 714, 300 mg AMG 714, or placebo using permuted blocks and stratified by study site and sex.

154 Randomisation was balanced using permuted blocks and was stratified by country, gender, a

155 Patients were randomly assigned in permuted blocks by region immediately before surgery, wi

156 al, participants were randomly assigned with permuted blocks in a 1:1 ratio to davunetide (30 mg twic

157 treatment, and assignments were generated by permuted blocks in the institutional database.

158 one with computer-generated randomisation in permuted blocks of 20, stratified by centre and age youn

159 y a computerised randomisation sequence with permuted blocks of 3.

160 Patients were randomly assigned in permuted blocks of eight and stratified by hospital to r

161 sation schedule was computer generated, used permuted blocks of four and six, and was stratified by p

162 e used a telephone randomisation method with permuted blocks of four generated by a computer.

163 mly assigned (1:1), using web-based randomly permuted blocks of four, to receive insulin via the day-

164 mputer-generated randomisation software with permuted blocks of four.

165 latin-containing chemotherapy regimen, using permuted blocks of four.

166 a computer-generated randomisation list with permuted blocks of nine.

167 sing a random number generator program, with permuted blocks of random size, stratified by location [

168 l by use of a secure schedule generated with permuted blocks of randomly varying block sizes.

169 rednisolone (0.5 mg/kg per day) using random permuted blocks of randomly varying size, and stratified

170 Randomisation was computer generated in permuted blocks of six and was stratified by study site.

171 ndomly assigned (2:1), by computer-generated permuted blocks of six with an interactive voice or web

172 location by use of computer-generated random permuted blocks of six, to either cediranib (30 mg orall

173 ngoscopy or direct laryngoscopy using random permuted blocks of size 2, 4, and 6, and stratified by s

174 isation sequence was computer generated with permuted blocks of size 4 and 6 and stratified by site.

175 Randomisation was computer generated, with permuted blocks of size eight, and stratified by CD4 cou

176 Patients were randomised using randomly permuted blocks of size four and six and stratified by s

177 er-based randomisation was done using random permuted blocks of size two or four for each site to pre

178 ntrally randomly assigned 1:1 using randomly permuted blocks of size two, four, or six to receive six

179 bility by means of computer-generated random permuted blocks of sizes 3 and 6 in equal proportion.

180 ts were randomly assigned (1:1), in randomly permuted blocks of ten, to either cholecalciferol 1000 I

181 ents were randomly assigned (1:1:1 in random permuted blocks of three or six) to receive standard shu

182 ied by site, and was computer-generated with permuted blocks of three patients per block.

183 nger since illness onset were generated with permuted blocks of variable length between two and eight

184 ere stratified by hospital and randomized in permuted blocks of variable size.

185 Randomisation was stratified, using random permuted blocks of variable sizes.

186 Randomisation was with permuted blocks of varying size and stratified by centre

187 ter-generated pseudo-random code with random permuted blocks of varying sizes of two, four, or six to

188 9:1 in a double-blind fashion using randomly permuted blocks of varying sizes to a single injection o

189 a computer-generated schedule using randomly permuted blocks prepared under the sponsor's supervision

190 Patients were allocated to treatment using a permuted blocks randomisation scheme (block size of four

191 A permuted blocks randomised design (block size four) was

192 otherapy plus bevacizumab), centrally, using permuted blocks sizes and stratified by chemotherapy reg

193 le patients were randomly assigned (1:1) via permuted blocks stratified according to hormone receptor

194 ing computer-generated sequences of randomly permuted blocks stratified by center to receive either E

195 ing computer-generated sequences of randomly permuted blocks stratified by centre to receive either E

196 he randomisation sequence was generated with permuted blocks stratified by hormone receptor status (h

197 Randomisation was by permuted blocks stratified by length of first remission

198 icipants were randomized using site-specific permuted blocks stratified by major depression into grou

199 Randomisation was done using permuted blocks stratified by study site.

200 normoalbuminuria were randomized (1:1) with permuted blocks to 6 months of a 25% calorie restricted

201 from each donor was randomly assigned using permuted blocks to oxygenated hypothermic machine perfus

202 isation schedule and balanced using randomly permuted blocks to receive daratumumab subcutaneously (s

203 randomly assigned (1:1) centrally by use of permuted blocks to receive induction therapy with either

204 rough a centralised randomisation service in permuted blocks to receive once daily inhaled placebo, f

205 assigned by online randomisation (1:1) with permuted blocks to the Solomon technique or standard las

206 Randomisation with permuted blocks was done with the International Breast C

207 -generated randomisation list using randomly permuted blocks with a block size of eight and were stra

208 tients were randomly assigned 1:1 (by random permuted blocks with block sizes of two and four, no mas

209 Randomisation used random permuted blocks with lengths of two, four, and six, and

210 Randomisation was balanced by using randomly permuted blocks with size of four and was stratified bas

211 famide and etoposide (MAPIE) using concealed permuted blocks with three stratification factors: trial

212 uences produced on the principle of randomly permuted blocks with variable block sizes of two and fou

213 interactive response technology by means of permuted blocks within strata (block size of 3 or 6) to

214 line of therapy, and randomly assigned using permuted blocks within strata to receive open-label oral

215 inistered system with variable-length random permuted blocks): C+P, conventional carious lesion manag

216 Randomisation was balanced by using randomly permuted blocks, and patients were stratified by T categ

217 ndomisation was done with computer-generated permuted blocks, and stratification was by centre and pr

218 urses recommended) or no chemotherapy, using permuted blocks, and stratified by previous chemotherapy

219 tion was done with computer-generated random permuted blocks, stratified according to recruitment sta

220 on schedule was computer generated in random permuted blocks, stratified by centre, number of nodes i

221 ly allocated participants (1:1) according to permuted blocks, stratified by germline BRCA status and

222 ndomisation was by computer-generated random permuted blocks, stratified by National Comprehensive Ca

223 ternet-based allocation sequence with random permuted blocks, to have a molecular POC test for respir

224 s computer-generated and randomisation, with permuted blocks, was done centrally with an interactive

225 stage, receptor status, and country and used permuted blocks.

226 -blind randomisation was done centrally with permuted blocks.

227 Randomisation was balanced by using randomly permuted blocks.

228 sation table, stratified by site with random permuted blocks.

229 randomly assigned (1:1:1, computer-generated permuted blocks; stratified by baseline disease-modifyin

230 randomly assigned (1:1:1, computer-generated permuted blocks; stratified by baseline DMARD and previo

231 er plus lumefantrine group or AQ-13 group by permuting blocks of four with a random number generator.

232 uence to randomly assign patients (2:1, with permuted-blocks of size three or six and stratified by s

233 ed within the protospacer, we use circularly permuted Cas9 variants to produce four cytosine and four

234 nce energy transfer (FRET) from a circularly permuted CFP mutant to FlAsH, a selectively reactive flu

235 c susceptibility tensor as the Ln(3+) ion is permuted conspire to mask modest changes in NMR paramagn

236 l culture compared to unmodified virus and a permuted control (CDLR).

237 to cell type differences, yet robust against permuted data and validated in targeted deep-sequencing

238 d at different resolutions and from randomly permuted data sets were consistent.

239 tral hypergeometric distribution to generate permuted data sets with the same structure present in th

240 d on a case-by-case basis, and the resulting permuted data were compared with the actual events prece

241 a new subfamily of GH3 proteins with a novel permuted domain topology.

242 ended triptycenes with up to three different permuted electron-accepting units and an electron-rich v

243 as a well-calibrated type I error rate using permuted ENCODE ChIP-seq data sets; in contrast, two com

244 The circularly permuted Escherichia coli enzyme, which exists as a molt

245 strate that when those sequence elements are permuted, even higher accuracy is obtained; we also prop

246 aB and IcaB and contains the same circularly permuted family four carbohydrate esterase motifs.

247 The resulting circularly permuted FLIPPi sensor was subjected to a high-efficienc

248 These circularly permuted FLIPPi sensors, therefore, enable detailed anal

249 site-specifically introduced into circularly permuted fluorescent proteins.

250 ion of ribose, likely because the circularly permuted form folds much more slowly than the nonpermute

251 shows a striking similarity to a circularly permuted form of encephalomyocarditis virus J-K domain,

252 ds: the wild-type structure and a circularly permuted form.

253 mpatible with an evolutionary route in which permuted genes result from a duplication event followed

254 phosphatase domain removed and a circularly permuted GFP placed in the S3-S4 linker.

255 structure-guided design of HIV-1 cyclically permuted gp120 that forms homogeneous, stable trimers, a

256 n of a boronic acid moiety into a circularly permuted green fluorescent protein (cpGFP) followed by d

257 voltage sensor design in which a circularly permuted green fluorescent protein is inserted in an ext

258 LSSmOrange) within a reporter FP (circularly permuted green FP).

259 mber of Cas10 family of proteins, that has a permuted histidine-aspartate domain and a nucleotidyl cy

260 These results suggest that cyclically permuted HIV-1 gp120 trimers represent a viable platform

261 Constructs that were cyclically permuted in the V1 loop region and contained an N-termin

262 caspase-1 target sequence into a circularly permuted luciferase construct that becomes bioluminescen

263 Biosensors were engineered from a circularly permuted luciferase, linked internally by either caspase

264 GCK biosensor was optimized using circularly permuted mCerulean3 proteins.

265 Strikingly, the fold topology of MCP is permuted non-circularly from the Johnson fold topology p

266 ets were used to evaluate performance, and a permuted null dataset was used to identify overfitting t

267 forestation compared to a synthetic control, permuted P = 0.038).

268 ermuted 95% confidence interval: 1-10 genes; permuted P = 3 x 10(-)(5)).

269 Combining original peptides A, B, and C and permuted peptides D, E, and F resulted primarily in form

270 pproach for creating libraries of circularly permuted proteins is described that is called PERMutatio

271 was tested on two collections of circularly permuted proteins.

272 lows the structural comparison of circularly permuted proteins.

273 herein the design of cpRAPID as a circularly permuted rapamycin-inducible dimerization system compose

274 erminal repeats versus those with circularly permuted repeats at their termini, thus providing new in

275 We first identified a circularly permuted RFP (cpRFP) scaffold, which maintained its auto

276 ynamics studies of the normal and circularly permuted sequences, as well as their constituent hairpin

277 ble a flexible interface for imaging through permuted set of fibers.

278 ently attached beta-strand from a circularly permuted split GFP, allowing the interaction to be rever

279 ment events in Thermoproteus tenax created a permuted SRP RNA gene.

280 d cytosolic ATP from insertion of circularly permuted superfolder GFP into the epsilon subunit of F(0

281 We also introduce an algorithm, permuted-SVA (pSVA), using a new statistical model that

282 A PWM algorithm enabling permuted switching of the PV sources is applied.

283 ies (Na(+), K(+), Li(+), Mg(2+), and Ca(2+)) permute the effects of lysine acetylation on the rate of

284 s applications, it is currently customary to permute the outcome variable in order to produce inferen

285 atistical significance is judged by randomly permuting the affected status in the CDS.

286 ling junctions based on the observation that permuting the order of R1 and R2 in the junction does no

287 In this paper, we show that permuting the outcome may produce unexpected results, in

288 empirically to give 95% specificity based on permuting the series.

289 By permuting the topology of the four helices within FRB, w

290 The WNK1-AI has a circularly permuted topology relative to the OSR1-PF2 domain.

291 ssociated with pediatric VTE with unpermuted/permuted values of P = 1.42 x 10(-6)/2.0 x 10(-6) and P

292 essful involved the creation of a circularly permuted version of a green-to-red photoconvertible FP a

293 ated activity and appears to be a circularly permuted version of the known lipoate ligase proteins in

294 mponent of a FLIPPi sensor with a circularly permuted version of Venus enhanced sensor dynamic range

295 perstable Pin1 WW domain has been circularly permuted via excision of the fold-nucleating turn; it st

296 dase-like domain and a C-terminal circularly permuted winged-helix-turn-helix domain.

297 ich we constructed by inserting a circularly permuted yellow fluorescent protein (cpYFP) into a regio

298 initially developed by inserting circularly permuted yellow fluorescent protein (cpYFP) into the NAD

299 biosensor, mitochondria-targeted circularly permuted YFP (mt-cpYFP).

300 port here that Emb14 gene encodes a circular permuted, YqeH class GTPase protein that likely function