ライフサイエンスコーパス: peroxiredoxin

1 sbF interaction partner, Rv1676, a predicted peroxiredoxin.

2 removal was observed following oxidation of peroxiredoxin.

3 des and regulates the expression of the OhrA peroxiredoxin.

4 tic mechanism of Asp f3, a two-cysteine type peroxiredoxin.

5 tion status of tubulin, HSP90, TGF-beta, and peroxiredoxins.

6 mple assay to quantify the hyperoxidation of peroxiredoxins.

7 roxyperoxide reductase E (AhpE), among other peroxiredoxins.

8 entative of the major class of bacterial BCP peroxiredoxins.

9 ses, catalases, glutathione-peroxidases, and peroxiredoxins.

10 x homeostasis through reducing hyperoxidized peroxiredoxins.

11 xy-eicosatetraenoic acids also over-oxidized peroxiredoxins.

12 was associated with increased expression of peroxiredoxin 1 (P<0.05), peroxiredoxin 3 (P<0.01), and

13 igomers and shifts in isoelectric points for peroxiredoxin 1 (Prdx-1), Prdx-3, and Prdx-4 isoforms wi

14 Recent studies suggest that Peroxiredoxin 1 (Prdx1), in addition to its known H(2)O(

15 In particular, the antioxidant protein peroxiredoxin 1 (Prx1) exhibited both decreased expressi

16 Peroxiredoxin 1 (Prx1) has been found to be elevated in

17 Peroxiredoxin 1 (Prx1) is an antioxidant and molecular c

18 In the present study, we showed that peroxiredoxin 1 (Prx1), a member of the peroxiredoxin pr

19 re used to assess the effect of UVB on TOPK, peroxiredoxin 1 (Prx1), and apoptosis in RPMI7951 cells.

20 lar proteins such as heat shock proteins and peroxiredoxin 1 (Prx1).

21 enerated from oxidation of Trx1 catalyzed by peroxiredoxin 1 in the presence of H2O2.

22 te-cysteine ligase catalytic subunit, ABCC1, peroxiredoxin 1).

23 1s) and the antioxidant enzymes catalase and peroxiredoxin 1, which may influence antioxidant potenti

24 Human peroxiredoxins 1 and 2, also known as Prx1 and Prx2, are

25 se-1, and cyclooxygenase-2 oxidize the 2-Cys-peroxiredoxins 1, 2, and 3 to their sulfinic and sulfoni

26 gi apparatus tether, and antioxidant enzymes peroxiredoxins 1-2.

27 xidases, or by overexpression of catalase or peroxiredoxin-1 (Prx-1).

28 /SNO may affect the redox cycle of mammalian peroxiredoxin-1 (Prx1), a representative of the 2-Cys Pr

29 ically interacts with the antioxidant enzyme peroxiredoxin-1 (PRX1), protects it from proteasome-medi

30 (2) (mH(2)O(2)) acting via the redox sensor, peroxiredoxin-1, a thiol peroxidase with high reactivity

31 ation of primary antioxidant systems such as peroxiredoxins-1, heme oxygenase-1, and anti-apoptotic f

32 Intriguingly, we identified peroxiredoxin 2 (PRDX2) as a novel potential tumor suppr

33 Peroxiredoxin 2 (Prx2) is a thiol protein that functions

34 ductase 1 (TrxR1), thioredoxin 1 (Trx1), and peroxiredoxin 2 (Prx2) together with NADPH.

35 nduces CDK5/p25-dependent phosphorylation of peroxiredoxin 2 (Prx2), resulting in inhibition of its p

36 estigated interactions between PTP1B and the peroxiredoxin 2 (Prx2)/thioredoxin 1 (Trx1)/thioredoxin

37 y in vitro; during therapy, disulfide-linked peroxiredoxin 2 dimer did not accumulate in red blood ce

38 tropomyosin alpha4 p=0.0108), antioxidative (peroxiredoxin 2 p=0.0092), and anti-inflammatory effects

39 pical thioredoxin ACHT1 is oxidized by 2-Cys peroxiredoxin (2-Cys Prx) in Arabidopsis plants illumina

40 studies revealed the participation of 2-Cys peroxiredoxin (2-Cys PRX), a thiol-dependent peroxidase,

41 NTRC is an efficient reductant of 2-Cys peroxiredoxins (2-Cys Prxs) and thus is involved in the

42 on of Cys-sulfinic acid derivatives of 2-Cys peroxiredoxins (2-Cys Prxs), has been shown to catalyze

43 Many 2-Cys-peroxiredoxins (2-Cys-Prxs) are dual-function proteins,

44 alysis revealed that the antioxidant enzymes peroxiredoxin-2 (Prdx2) and heme oxygenase-1 were upregu

45 lammatory stimuli induce release of oxidized peroxiredoxin-2 (PRDX2), a ubiquitous redox-active intra

46 mitochondria to the cytosol was evidenced by peroxiredoxin-2 (Prx2) oxidation, and Prx3 collapse was

47 For example, S-nitrosylation of peroxiredoxin-2 (Prx2), a peroxidase widely expressed in

48 Two additional proteins, peroxiredoxin-2 and endophilin-1, are implicated in Abet

49 ased expression of peroxiredoxin 1 (P<0.05), peroxiredoxin 3 (P<0.01), and heme oxygenase-1 (HO-1) (P

50 e (Sod), glutathione peroxidase 4 (Gpx4) and peroxiredoxin 3 (Prdx3) that render them susceptible to

51 merase gamma, mitochondrial topoisomerase I, peroxiredoxin 3 and manganese superoxide dismutase--are

52 re, N-acetylcysteine increased the levels of peroxiredoxin 3 and superoxide dismutase 2 in adipose ti

53 Peroxiredoxin-3 (PRDX3) is a mitochondrial antioxidant e

54 LRRK2 has been shown to bind peroxiredoxin-3 (PRDX3), the most important scavenger of

55 interacts with the mitochondrial peroxidase peroxiredoxin-3 (PRDX3).

56 be inversely dependent on the total pool of peroxiredoxin-3 (Prx3).

57 uctions (P<0.001) in the antioxidant enzymes peroxiredoxin-3 and CuZn-superoxide-dismutase.

58 The mitochondrial peroxidase peroxiredoxin-3 reduces H(2)O(2) to water using reducing

59 ion of a mitochondria-localized antioxidant (peroxiredoxin-3) was protective against VIDD.

60 unolabeling for markers of oxidative stress (peroxiredoxin-3/5) and for a lipid peroxidation product

61 Here, we report that peroxiredoxin 4 (PRDX4) is a putative tumor driver.

62 The endoplasmic reticulum (ER)-localized peroxiredoxin 4 (PRDX4) supports disulfide bond formatio

63 Peroxiredoxin 4 (Prdx4), an ER-specific antioxidative pe

64 llothionein 3 (Mt3), tetraspanin 2 (Tspan2), peroxiredoxin 4 (Prdx4), stathmin-like 2 (Stmn2), myelin

65 Peroxiredoxin 4 (Prx4) has been implicated in a wide var

66 Blocking either Akt or peroxiredoxin 4 activity with Akt Inhibitor IV or a pero

67 study examined the role of Akt signaling and peroxiredoxin 4 expression in human umbilical cord blood

68 o increased Akt phosphorylation and elevated peroxiredoxin 4 expression in oligodendrocytes.

69 cord blood cells converge on Akt to elevate peroxiredoxin 4 levels, and these effects contribute to

70 occlusion increased Akt phosphorylation and peroxiredoxin 4 protein expression while reducing proteo

71 transferase 1A and reductions in mitofusin1, peroxiredoxin 4, and fumarate hydratase.

72 edoxin 4 activity with Akt Inhibitor IV or a peroxiredoxin 4-neutralizing antibody, respectively, neg

73 , we show that the thiol-specific peroxidase peroxiredoxin-4 (Prdx4) directly regulates IL-1beta gene

74 t enzymes, superoxide dismutase 1 (SOD1) and peroxiredoxin-4 (PRDX4) during hyperosmotic stress.

75 s), NAD(P)H quinone oxidoreductase-1 (Nqo1), peroxiredoxin-4 (Prdx4), and serine peptidase inhibitor

76 anganese-containing superoxide dismutase and peroxiredoxin 5 were only upregulated by PgLPS1690.

77 e E1, PYGB, Pgm2), and antioxidant proteins (peroxiredoxin 5, ferritin heavy chain 1) following rapam

78 f four proteins (macrophage capping protein, peroxiredoxin 5, heterogeneous nuclear ribonucleoprotein

79 ther by crystallography or NMR for the human peroxiredoxin 5, their affinities were for the first tim

80 ynthase, sperm equatorial segment protein 1, peroxiredoxin-5, secretoglobin family 1D and glucose-6-p

81 Sperm of bulls was related to seminal plasma peroxiredoxin-5, spermadhesin-1 and the spermadhesin-1 x

82 Herein we show that the transduction of Peroxiredoxin 6 (PRDX6) attenuates TNF-alpha- and glutam

83 Peroxiredoxin 6 (PRDX6) is a key regulator of cellular r

84 The antioxidant enzyme peroxiredoxin 6 (Prdx6) is a key regulator of the cellul

85 Peroxiredoxin 6 (Prdx6) is essential for activation of N

86 o show that following opioid administration, peroxiredoxin 6 (PRDX6) is recruited to the opioid recep

87 holipase A2 (PLA2)activity of phosphorylated peroxiredoxin 6 (Prdx6) is required for activation of NA

88 how that opioid receptor activation recruits peroxiredoxin 6 (PRDX6) to the receptor-Galphai complex

89 Peroxiredoxin 6 (Prdx6), a bifunctional enzyme with glut

90 Peroxiredoxin 6 (Prdx6), a bifunctional protein with pho

91 We identified peroxiredoxin 6 (Prdx6), a host factor that contributes

92 opioid, and D2 dopamine receptors stimulates peroxiredoxin 6 (PRDX6)-mediated production of reactive

93 The phospholipase A2 activity of peroxiredoxin 6 modulates NADPH oxidase 2 activation via

94 or of PRDX6 and suggest that co-targeting of peroxiredoxin 6 or modulating miR-371-3p expression toge

95 We identify PRDX6 (peroxiredoxin 6) as a key target of miR-371-3p in establ

96 cs analysis, we found that uterine levels of peroxiredoxin-6 (PRDX6), a unique antioxidant, are signi

97 r BQ-123, or ROS scavenging after SDRT using peroxiredoxin-6 overexpression or the SOD mimetic tempol

98 transporter (EAAT-2), apo-J (Clusterin), and peroxiredoxin-6) are selectively expressed in astrocytes

99 One Zap1 target gene encodes the Tsa1 peroxiredoxin, a protein with both peroxidase and protei

100 The peroxiredoxins, a family of peroxidases initially descri

101 roxidase and glutathione peroxidase, and the peroxiredoxin abundance were increased for ROS scavengin

102 s and their changes are closely connected to peroxiredoxin activity and function but so far have been

103 one and thioredoxin oxidation and suppressed peroxiredoxin activity in vitro.

104 this residue was not absolutely required for peroxiredoxin activity.

105 mes such as thioredoxins (Trx1 and Trx2) and peroxiredoxin Ahp1 in a Grh1-dependent manner.

106 We have confirmed that the peroxiredoxin Ahp1 is such a substrate in S. cerevisiae

107 tributions of the sole catalase KatE and the peroxiredoxin AhpC produced by these strains in defense

108 The bacterial peroxiredoxin AhpC, a cysteine-dependent peroxidase, can

109 rains is restored by a mutant (ahpC*) of the peroxiredoxin AhpC, converting it to a disulfide reducta

110 tress includes the flavoprotein AhpF and the peroxiredoxin AhpC.

111 disulfide center of the antioxidant protein peroxiredoxin (AhpC) to detoxify ROS such as hydrogen pe

112 The one-cysteine peroxiredoxin alkyl hydroperoxide reductase E from Mycob

113 that mass spectrometry shows contained 2-Cys peroxiredoxin also formed and precedes the appearance of

114 ne, a residue that occurs in place of Pro in peroxiredoxins, also led to the formation of the cluster

115 acks with a putative antioxidant OsmC family peroxiredoxin, an indicator of oxidative stress derived

116 arrying 2 functional elements, an N-terminal peroxiredoxin and a C-terminal chitinase domain.

117 ing the thioredoxin peroxidase activity of a peroxiredoxin and increasing the hydrogen peroxide resis

118 two proteins with antioxidative properties (peroxiredoxin and superoxide dismutase), and three prote

119 chanism is similar to that of atypical 2-Cys peroxiredoxin and that selenocysteine allows SelS to sus

120 and structural features of the mitochondrial peroxiredoxin and thioredoxin of P. falciparum.

121 in reveals a fold typical of the 2-Cys class peroxiredoxins and a dimeric form with an intermolecular

122 were identified, including ATPase, clathrin, peroxiredoxins and enolase, which may provide clues to t

123 h wild-type and mutant strains deficient for peroxiredoxins and glutathione peroxidases were equally

124 H2O2 is under sophisticated fine control of peroxiredoxins and glutathione peroxidases with their ba

125 d that Sesn2 physically interacts with 2-Cys peroxiredoxins and Nrf2 albeit under different reductive

126 ting from nonlinearity of H2O2 scavenging by peroxiredoxins and our study reveals that this regulator

127 s, including cysteine-dependent peroxidases (peroxiredoxins) and proteases, only relatively few pK(a)

128 y on select proteins, including thioredoxin, peroxiredoxins, and other validated redox active protein

129 Peroxiredoxins are a diverse and ubiquitous family of hi

130 Peroxiredoxins are central to cellular redox homeostasis

131 Peroxiredoxins are H(2)O(2) scavenging enzymes that also

132 d out in this list, as the related cytosolic peroxiredoxins are known to form disulfides in the prese

133 Typical 2-Cys peroxiredoxins are known to switch between different oli

134 Typical 2-Cys peroxiredoxins are required to remove hydrogen peroxide

135 Peroxiredoxins are ubiquitous proteins that catalyze the

136 ain the phenotypic differences, and identify peroxiredoxin as an important component of virulence in

137 including the redox proteins thioredoxin and peroxiredoxin, as well as the growth factor receptors IG

138 Here we show that the peroxiredoxin Asp f3 of Aspergillus fumigatus inactivate

139 ctrometry, we recently reclassified one such peroxiredoxin, bacterioferritin comigratory protein (BCP

140 to use this insight to improve the design of peroxiredoxin-based redox biosensors.

141 2-Cys peroxiredoxins belonging to the Prx1 subfamily are Cys-b

142 ssion of an antioxidative enzyme, 2-Cysteine peroxiredoxin (BxPrx), was elevated in B. xylophilus fol

143 ces cerevisiae Altogether, the processing of peroxiredoxins by Imp2 or Oct1 likely represents systems

144 the selective benefits endowed to eukaryotic peroxiredoxins by their reversible hyperoxidation.

145 Hyperoxidation of peroxiredoxins can only occur efficiently in the presenc

146 demonstrate a clear physiological role for a peroxiredoxin chaperone and reveal a novel and unexpecte

147 i containing the disaggregase Hsp104 and the peroxiredoxin chaperone Tsa1.

148 The peroxiredoxin clearly preferred PfTrx2 to PfTrx1 as a re

149 ongs to the atypical 2-cysteine subfamily of peroxiredoxins, commonly referred to as bacterioferritin

150 AhpC, the peroxide-reducing (peroxiredoxin) component of this alkyl hydroperoxidase s

151 We also explore how peroxiredoxins contribute to YROs.

152 In these 2-Cys peroxiredoxins, decamer formation is important for the c

153 Peroxiredoxin-dependent mechanisms may modulate the rece

154 multiple aging-related conduits, including a peroxiredoxin-dependent response to H(2)O(2).

155 The functional versatility of peroxiredoxins depends on progressive oxidation of key c

156 Deletion of TSA1, which encodes a peroxiredoxin, exacerbated iron toxicity in Deltaccc1 ce

157 Prx1, a peroxiredoxin family member, was shown to be frequently

158 typhimurium AhpC is a founding member of the peroxiredoxin family, a ubiquitous group of cysteine-bas

159 osis Tpx is a member of the atypical two-Cys peroxiredoxin family.

160 fatty acids (FA) desaturases do not require peroxiredoxins for their activity, nor does FAD4 require

161 ved the crystal structure of a typical 2-Cys peroxiredoxin from Leishmania in the dimeric (pH 8.5) an

162 Thiol peroxidases (Tpxs) are dimeric 2-Cys peroxiredoxins from bacteria that preferentially reduce

163 to those obtained for two typical 2-cysteine peroxiredoxins from Saccharomyces cerevisiae (5.4 and 6.

164 atalase (encoded by hktE) and a bifunctional peroxiredoxin-glutaredoxin (encoded by pdgX) in resistan

165 on these data, we conclude that catalase and peroxiredoxin-glutaredoxin are determinants of bacterial

166 These include catalase (HktE), peroxiredoxin/glutaredoxin (PgdX), and a ferritin-like p

167 porins and H(2) O(2) is removed by catalase, peroxiredoxin, glutathione peroxidase-like enzymes and a

168 circadian oscillations in the redox state of peroxiredoxin have been described as an additional non-t

169 Cytosolic eukaryotic 2-Cys-peroxiredoxins have been widely reported to act as dual-

170 Using red blood cells, we found that peroxiredoxins, highly conserved antioxidant proteins, u

171 and contribute to osteoarthritis and suggest peroxiredoxin hyperoxidation as a potential mechanism.

172 Peroxiredoxin hyperoxidation was associated with inhibit

173 Peroxiredoxin hyperoxidation was observedin situin human

174 stimulation, the expression and oxidation of peroxiredoxin II (PrdxII), a critical antioxidant enzyme

175 have been due to the absence of catalase and peroxiredoxin in the purified Hb.

176 perones, Hsp33 in bacteria and typical 2-Cys peroxiredoxins in eukaryotes.

177 ism to stabilize the decameric form of 2-Cys peroxiredoxins in Leishmania mitochondria.

178 the structure and function of typical 2-Cys peroxiredoxins in response to oxidative stress.

179 Thus, AhpC and potentially other peroxiredoxins in this widespread family can elaborate a

180 the expression of Prx III, the mitochondrial peroxiredoxin, in human cardiac fibroblasts.

181 tive oxygen species, oxidizing mitochondrial peroxiredoxin, inactivating AKT/mTOR/p70S6K signaling, a

182 l, Day et al. reveal a surprising benefit of peroxiredoxin inactivation at high H(2)O(2), showing tha

183 ans Srx1 was also found to be required for a peroxiredoxin-independent function in promoting fungicid

184 support the subdivision of the BCP family of peroxiredoxins into two classes based on their catalytic

185 tive cysteine, the resolving cysteine of BCP peroxiredoxins is not conserved across all members of th

186 the use of the approach to compare different peroxiredoxin isoforms and to identify mutations and sma

187 Together with 2-cysteine peroxiredoxin, it forms a two-component peroxide-detoxif

188 ein folding, which led to the discovery that peroxiredoxin IV (PRDX4) catalyzes a parallel oxidation

189 Peroxiredoxin IV (PRDX4) stood out in this list, as the

190 produced can be metabolized by ER-localized peroxiredoxin IV (PrxIV).

191 r mitochondria, leading to the protection of peroxiredoxin IV from hyperoxidation.

192 Our results demonstrate that peroxiredoxin IV recycling in the endoplasmic reticulum

193 quence similarity 213, member A (FAM213A), a peroxiredoxin-like antioxidative protein, was repressed

194 spectrometry reveal that DJ-1 is an atypical peroxiredoxin-like peroxidase that scavenges H(2)O(2) th

195 hysiological function of DJ-1 as an atypical peroxiredoxin-like peroxidase.

196 peroxidase, the parasites rely primarily on peroxiredoxin-linked systems for protection.

197 The sulfinic or sulfonic forms of peroxiredoxin lose their peroxidase activity, which allo

198 These results show that the mitochondrial peroxiredoxin of P. falciparum occurs in both dimeric an

199 or that represses expression of an inducible peroxiredoxin, OhrA.

200 riod determination by CK1 and GSK3, and have peroxiredoxin over-oxidation cycles.

201 2 is mediated by an evolutionarily conserved peroxiredoxin-p38/MAPK signaling cascade.

202 atalysis occurs via an atypical two-cysteine peroxiredoxin pathway.

203 he mitohormetic pathway is propagated by the peroxiredoxin PRDX-2.

204 ire GUR-3 and a conserved antioxidant enzyme peroxiredoxin PRDX-2.

205 The peroxiredoxin (Prdx) family of antioxidant enzymes uses

206 glucose-6-phosphate dehydrogenase (G6PD) and peroxiredoxin (PRDX).

207 roxidase activity of the antioxidant protein peroxiredoxin (Prdx-1) in breast cancer cells.

208 regulation of ROS/RNS is largely attended by peroxiredoxins (Prdxs) and their main reductants, thiore

209 Peroxiredoxins (Prdxs) are small H(2)O(2) scavenging pro

210 rtile, and the deficiency or inactivation of Peroxiredoxins (PRDXs) is associated with human male inf

211 , peroxynitrite, and organic hydroperoxides, peroxiredoxins (Prdxs) represent a major potential prote

212 that peroxiredoxin 1 (Prx1), a member of the peroxiredoxin protein family, acts as a key mediator in

213 ediated by the membrane protein GDE2 and the peroxiredoxin protein Prdx1 that promotes neurogenesis.

214 n the oxidation state of a broadly conserved peroxiredoxin protein.

215 We identify oxidation of peroxiredoxin proteins as a transcription-independent rh

216 e we show that oxidation-reduction cycles of peroxiredoxin proteins constitute a universal marker for

217 TXNRD1) and sulfiredoxin (SRXN1), suggesting peroxiredoxin proteins had been oxidized during monoHAA

218 t discovery of oxidation-reduction cycles of peroxiredoxin proteins, which persist even in the absenc

219 ing, e.g., over-oxidation cycles of abundant peroxiredoxin proteins.

220 PREX is a database of currently 3516 peroxiredoxin (Prx or PRDX) protein sequences unambiguou

221 Although this Tp peroxiredoxin (Prx) closely resembles AhpC-like Prxs, Tp

222 PC-mutation-positive colorectal cancer.2-Cys peroxiredoxin (Prx) enzymes are highly expressed in most

223 Mammalian 2-Cys peroxiredoxin (Prx) enzymes are overexpressed in most ca

224 parasite Leishmania infantum, mitochondrial peroxiredoxin (Prx) exerts intrinsic ATP-independent cha

225 The peroxiredoxin (PRX) family of antioxidant enzymes helps

226 iscovery that the redox regulatory proteins, peroxiredoxin (Prx) I and Prx II are specific targets of

227 Srx preferentially interacts with Peroxiredoxin (Prx) IV relative to other Prxs due to its

228 ivity in vitro Remarkably, the processing of peroxiredoxin (Prx) proteins by Oct1 appears to be an ev

229 efenses by making changes to the thioredoxin-peroxiredoxin (Prx) system.

230 terioferritin comigratory protein (BCP) is a peroxiredoxin (Prx) that catalyzes the reduction of H(2)

231 tive site cysteine of the antioxidant enzyme peroxiredoxin (Prx) to the sulfinic acid form, Prx-SO(2)

232 estingly, ACHT1 oxidation is driven by 2-Cys peroxiredoxin (Prx), which in turn eliminates peroxides.

233 zymes and reduced formation of hyperoxidized peroxiredoxin (Prx)2.

234 This reaction is unique to the typical 2-Cys peroxiredoxins (Prx) and plays a role in peroxide-mediat

235 Peroxiredoxins (PRX) are a family of antioxidant enzymes

236 Eukaryotic 2-Cys peroxiredoxins (Prx) are abundant antioxidant enzymes wh

237 Peroxiredoxins (PRX) are critical intracellular antioxid

238 Peroxiredoxins (Prx) are efficient thiol-dependent perox

239 Evidence implicates peroxiredoxins (Prx) as providing the main enzymatic act

240 Peroxiredoxins (Prx) make up a family of enzymes that re

241 of the active site cysteine in typical 2-Cys peroxiredoxins (Prx) to sulfinic acid during oxidative s

242 Peroxiredoxins (Prx), a family of peroxidases that reduc

243 to study the interactions between H(2)S and peroxiredoxins (Prx).

244 st Oct1 could cleave the human mitochondrial peroxiredoxin Prx3 when expressed in Saccharomyces cerev

245 ed to oxidative stress resistance, including peroxiredoxin PrxA, in response to hydrogen peroxide.

246 The mitochondrial 2-Cys peroxiredoxin PrxIII serves as a thioredoxin-dependent p

247 Peroxiredoxins (Prxs or Prdxs) are a large protein super

248 reduces hyperoxidized 2-cysteine-containing peroxiredoxins (Prxs) and protects cells against oxidati

249 nt peroxidases, including 2-cysteine (2-Cys) peroxiredoxins (PRXs) and thylakoid ascorbate peroxidase

250 Peroxiredoxins (Prxs) are a ubiquitously expressed famil

251 Peroxiredoxins (Prxs) are crucially involved in maintain

252 Peroxiredoxins (Prxs) are highly conserved proteins foun

253 Peroxiredoxins (Prxs) are important peroxidases associat

254 O2H) residues, the sulfinic forms of certain peroxiredoxins (Prxs) are selectively reduced by sulfire

255 st group, glutathione peroxidases (GPxs) and peroxiredoxins (Prxs) are the most widespread and abunda

256 Typical 2-Cys peroxiredoxins (Prxs) are ubiquitous peroxidases that ar

257 Peroxiredoxins (Prxs) are vital regulators of intracellu

258 ether with thioredoxin reductase 1 (TR1) and peroxiredoxins (Prxs) comprises a key redox regulatory s

259 Peroxiredoxins (Prxs) detoxify peroxides and modulate H2

260 Typical 2-Cys peroxiredoxins (Prxs) have an important role in regulati

261 2-Cys peroxiredoxins (Prxs) rapidly reduce H(2)O(2), thereby a

262 Typical 2-Cys peroxiredoxins (Prxs) react rapidly with H2O2 to form a

263 NTRC efficiently reduces 2-Cys peroxiredoxins (Prxs), thus having antioxidant function,

264 ed to react fast toward reactive thiols from peroxiredoxins (Prxs).

265 ing age-related oxidation of H2O2-scavenging peroxiredoxins (Prxs).

266 4) and a thylakoid-associated redox protein, PEROXIREDOXIN Q (PRXQ), to produce wild-type levels of 1

267 e polarization to monitor dynamic changes in peroxiredoxin quaternary structure inside the crowded en

268 In many bacteria, a dedicated peroxiredoxin reductase, alkyl hydroperoxide reductase s

269 Our results present in vivo evidence of a peroxiredoxin regulating DE-cadherin-mediated adhesion.

270 The crystal structure of the mitochondrial peroxiredoxin reveals a fold typical of the 2-Cys class

271 lose structural similarity to atypical 2-Cys peroxiredoxin(s) (Prx).

272 These observations may represent peroxiredoxin sensing and transducing the oxidant signal

273 Human peroxiredoxins serve dual roles as anti-oxidants and reg

274 Because of its evolutionary conservation, peroxiredoxin signaling might underlie a general princip

275 genases and cyclooxygenases may affect 2-Cys peroxiredoxin signaling, analogous to NADPH oxidases in

276 modulate the oligomeric transitions of 2-Cys peroxiredoxins such as redox state, post-translational m

277 provided further support for the thioredoxin/peroxiredoxin system as the major contributor to mitocho

278 H2O2 detoxification through the thioredoxin/peroxiredoxin system.

279 dent manner predominantly by the thioredoxin/peroxiredoxin system.

280 Yeast Prx1 is a mitochondrial 1-Cys peroxiredoxin that catalyzes the reduction of endogenous

281 ydroperoxide reductase subunit C (AhpC) is a peroxiredoxin that detoxifies peroxides.

282 P) of Escherichia coli, as an atypical 2-Cys peroxiredoxin that functions through the formation of an

283 For all of the peroxiredoxins, the catalytic cysteine, referred to as t

284 xpressions of those genes encoding catalase, peroxiredoxin, thioredoxin and glutathione were highly i

285 indicate that at high tissue H2O2 levels the peroxiredoxin-thioredoxin antioxidant chain becomes over

286 This detoxification pathway utilizes the peroxiredoxin/thioredoxin antioxidant system, as selecti

287 ignificant upregulation of components of the peroxiredoxin/thioredoxin pathway and processes involved

288 ivity of the endoplasmic reticulum-localized peroxiredoxin to hyperoxidation compared with either the

289 d that mutation of the TxxC active site in a peroxiredoxin to the CxxC form could lead to coordinatio

290 ctional gain that allows mitochondrial 2-Cys peroxiredoxins to act as molecular chaperones when formi

291 king one, at 1.4 A, one of the best resolved peroxiredoxins to date.

292 nhibitor-like allergen (Tri a 39), and 1-cys-peroxiredoxin (Tri a 32), produced the maximal area unde

293 y enhances the expression of the thioredoxin/peroxiredoxin (Trx/Prx) system with the greatest effect

294 In yeast, the major cytosolic peroxiredoxin, Tsa1 is required for both promoting resis

295 fungal meningoencephalitis and regulation of peroxiredoxins, Tsa1 and Tsa3, and thioredoxins, Trx1 an

296 regulon) and only one antioxidant gene, the peroxiredoxin TSA2.

297 ity, nor does FAD4 require other chloroplast peroxiredoxins under standard growth conditions.

298 creased expression of the antioxidant enzyme peroxiredoxin-V, and a non-significant trend towards dec

299 relative abundance of serpins Z1C and 1-Cys peroxiredoxin was increased at e[CO2].

300 the highly abundant eukaryotic typical 2-Cys peroxiredoxin, whose oxidative stress-induced sulfinic a