ライフサイエンスコーパス: peroxyl

1 way culminates with addition of the C21-O-O* peroxyl adduct to olefinic C27 followed by HAT to the C2

2 alpha-Tocopherol acts as a peroxyl and alkoxyl radical scavenger in lipid environme

3 result of a radical chain reaction involving peroxyl and carbon-centered radicals even though not det

4 n of supercoiled DNA strand from scission by peroxyl and hydroxyl radicals into the nicked circular f

5 MPR) was evaluated against hypochlorite ion, peroxyl and hydroxyl radicals, FME exhibit the greatest

6 A strand breakage inhibition induced by both peroxyl and hydroxyl radicals.

7 is(3-ethylbenzothiazoline-6-sulphonic acid), peroxyl and NO radicals as well as inhibition of low den

8 n inactivation of PFL revealed protein-based peroxyl and sulfinyl radicals during the manual mixing a

9 Peroxyl and superoxide RSAs of 96.8% and 88.6% were noti

10 ties: (i) radical scavenging activity toward peroxyl and toward ABTS radical (chain-breaking activity

11 y re-addition of oxygen to form the 11-HPETE peroxyl, and they exclude a mechanism proceeding through

12 adical scavenging assays: DPPH, hydroxyl and peroxyl; and Ferrous Ion-chelating Ability Assay).

13 sses of enzymes form quasi-stable C4a-(hydro)peroxyl FAD intermediates.

14 When challenged by hydroxyl or peroxyl free radicals or Abeta(1-42), oxidative stress a

15 lene groups adjoining the carbon bearing the peroxyl group and the protoporphyrin IX.

16 yme 12/15-lipoxygenase (12/15-LO) introduces peroxyl groups in a position-specific manner into unsatu

17 eterolytic bond dissociation energies of the peroxyl groups of small peroxides indicated that they ar

18 hese cross-molecular reactions of fatty acid peroxyls have also important implications for understand

19 ificantly higher TPC, total isoflavones, and peroxyl, hydroxyl, and ABTS(+) radical scavenging abilit

20 ggest that PGG2 binds the POX site through a peroxyl-iron bond, a hydrogen bond with His-207 and van

21 xyl (k approximately 1 x 10(9) M(-1) s(-1)), peroxyl (k approximately 2 x 10(6) M(-1) s(-1)), and thi

22 cals consume molecular oxygen forming either peroxyl or superoxide anion radicals.

23 d free radical scavenging activities against peroxyl (ORAC) and 2,2-diphenyl-1-picrylhydrazyl radical

24 1,1-Diphenyl-2-picryl-hydrazyl (DPPH-RS), peroxyl (PRS), and hydroxyl radical scavenging (HRS) and

25 The major reaction pathways for the peroxyl radical (1) derived from 5,6-dihydro-2'-deoxyuri

26 olecular hydrogen atom abstraction by the C6-peroxyl radical (14) and suggests that gamma-radiolysis

27 Under aerobic conditions, the peroxyl radical (2) derived from 1 reacts approximately

28 content (TPC), antioxidant capacity towards peroxyl radical (31.1%) as well as reducing power (39.5%

29 The reaction of the allyl group with a peroxyl radical (C-H hydrogen abstraction) proceeds with

30 we have clearly identified the generation of peroxyl radical (ROO(*)) by the unmodified SWCNT and the

31 s an (*)OH scavenger generates the secondary peroxyl radical (ROO(*)), influencing the oxidation of t

32 spectrum that we assign to the alpha-carbon peroxyl radical (ROO*) of the active-site glycine, G734.

33 turated fatty acids such as oxygen addition, peroxyl radical 5-exo cyclization, and S(H)i carbon radi

34 at lycopene, alpha-tocopherol, selenium, and peroxyl radical absorption capacity are unlikely to be a

35 or lycopene, alpha-tocopherol, selenium, and peroxyl radical absorption capacity.

36 n, lycopene, alpha-tocopherol, selenium, and peroxyl radical absorption capacity.

37 Products that arise from peroxyl radical abstraction at each position of the vari

38 AT) from a donor to the peroxyl radical; (b) peroxyl radical addition (PRA) to a "C C" double bond.

39 AT) from a donor to the peroxyl radical; (b) peroxyl radical addition (PRA) to a "C=C" double bond.

40 use the radical "ate" complexes derived from peroxyl radical addition to boron are sufficiently persi

41 orting the products resulting from competing peroxyl radical addition to cholesterol, the stereoisome

42 Kinetic studies revealed that peroxyl radical addition to the 5'-thymine was favored b

43 al products and provided direct evidence for peroxyl radical addition to the adjacent thymine bases.

44 chemically activated population of the major peroxyl radical adduct (*)O2CH2CH(OH)2 is predicted to u

45 were detected, to which rapidly decomposing peroxyl radical adducts also contributed.

46 ins with a hydrogen atom transfer, forming a peroxyl radical and a Compound II-like species.

47 imolecular beta-fragmentation (k(beta)) of a peroxyl radical and its bimolecular reaction with a hydr

48 ed by H-bond formation between the attacking peroxyl radical and the 3beta-OH.

49 e results also support the proposal that the peroxyl radical and the sulfinyl radical are intermediat

50 leads to accumulation of a substrate-derived peroxyl radical as a result of off-pathway trapping of t

51 ls at tyrosine and tryptophan residues and a peroxyl radical at an unknown location have been reporte

52 the energetic cost required to reorient the peroxyl radical at the rate-determining step.

53 We suggest that peroxyl radical beta-scission depends on solvent polarit

54 The peroxyl radical can serve as the seed for the production

55 This peroxyl radical clock methodology has been successfully

56 e analytical approach on the linoleate-based peroxyl radical clock to enable the simultaneous measure

57 yrylperacetate as a precursor to a versatile peroxyl radical clock with the present paper, wherein we

58 benzene, as determined by a newly developed peroxyl radical clock.

59 A series of peroxyl radical clocks has been developed and calibrated

60 Peroxyl radical clocks have been used to determine the r

61 Recently described peroxyl radical clocks offer a simple, convenient, and i

62 base modifications induced as a function of peroxyl radical concentration was determined by quantita

63 ased in a log linear fashion with respect to peroxyl radical concentration.

64 pproximately 10(6) s(-1)) of the bis-allylic peroxyl radical decreased on going from the cis,cis to t

65 ition of the adjacent 2'-deoxyuridine by the peroxyl radical derived from 1 (3) is observed under aer

66 andem lesions resulting from addition of the peroxyl radical derived from 1 to the 5'-adjacent nucleo

67 hydrogen atom abstraction by an intermediate peroxyl radical derived from linoleic acid that leads to

68 Subsequent HAT or combination with another peroxyl radical drives the reaction forward, such that a

69 ation involving beta-fragmentation of the 15-peroxyl radical followed by re-addition of oxygen to for

70 emarkable oxygen-dependent chain process via peroxyl radical formation and evolution to give the Delt

71 Peroxyl radical formation was not prevented by site-dire

72 contrast, mutation of tryptophan 14 prevents peroxyl radical formation, implicating tryptophan 14 as

73 histidinyl radical consumed oxygen, implying peroxyl radical formation.

74 ine flanks drastically reduced the extent of peroxyl radical G oxidation.

75 xidation system (ascorbate/Fe(II)/H2O2) or a peroxyl radical generating system, 2,2'-azobis(2-amidino

76 zobis-2,4-dimethyl valeronitrile (AMVN) as a peroxyl radical generator, and 6-hydroxy-2, 5,7,8-tetram

77 s-2-amidinopropane hydrochloride (AAPH) as a peroxyl radical generator; 6-hydroxy-2,5,7, 8-tetramethy

78 The minor peroxyl radical HOCH2C(OO(*))HOH is even less stable and

79 Reorientation of the peroxyl radical in the active site, concomitant with the

80 The sequence-specific distribution of peroxyl radical induced base damage was mapped for 803 n

81 Peroxyl radical induced tandem mutations were also obser

82 C-9 and C-11 of AA so that the incipient 11-peroxyl radical intermediate is able to add to C-9 to fo

83 [bond]oxygen bond dissociation enthalpies of peroxyl radical intermediates (R[bond]OO*) have been cal

84 differential evolution channels of isomeric peroxyl radical intermediates at the 2- versus 3-positio

85 cate that reactions of .NO with lipoxygenase peroxyl radical intermediates will result in modulation

86 t/KM(16,16O2)/kcat/KM(18,16O2) reveal that a peroxyl radical is formed in or before the first kinetic

87 The peroxyl radical is shown here to be localized on tryptop

88 the reduced catalytic tyrosine to a terminal peroxyl radical is the first irreversible step that cont

89 chanism starts with a 4-exo cyclization of a peroxyl radical leading to an intermediate dioxetane, a

90 dical in the active enzyme and the resulting peroxyl radical may react further with the sulfhydryl gr

91 esis and carcinogenesis, the contribution of peroxyl radical mediated DNA base damage is less well un

92 ngly suggests that H atom abstraction by the peroxyl radical occurs with substantial quantum mechanic

93 This new radical could be either a peroxyl radical of BH(4) or an amino acid radical was in

94 al oxidations depends on the position of the peroxyl radical on the 18-carbon chain.

95 a hydroperoxide activator and the incipient peroxyl radical oxidizes Tyr385, or (2) ferric enzyme re

96 uminate the physiological relevance of lipid peroxyl radical production during cell homeostasis and d

97 luorescence assay for monitoring kinetics of peroxyl radical reactions in liposomes is subsequently d

98 cular oxygen addition, and a factor of 5 for peroxyl radical reactions.

99 Reducing power (RP), DPPH and peroxyl radical scavenging (PRS) evaluated indirect anti

100 Employing this method, the relative peroxyl radical scavenging activities of Trolox, alpha-t

101 ts showed similar total phenolic content and peroxyl radical scavenging capacity, with hypochlorous a

102 tribution of epigallocatechin gallate in the peroxyl radical scavenging of green tea extracts.

103 eroxidation products to perflubron or by the peroxyl radical scavenging properties of perflubron.

104 ioxidants, is shown herein to exhibit potent peroxyl radical scavenging properties that are controlle

105 droxyl radical scavenging, 279.02 mug mL(-1) Peroxyl radical scavenging).

106 epoxyallylic radical, giving an epoxyallylic peroxyl radical that does not further react with Fe(III)

107 alkoxyamine that subsequently reacts with a peroxyl radical to eventually re-form the nitroxide.

108 substituents on the rearrangement of the C-3 peroxyl radical to give conjugated diene products.

109 ad suggest that the reversible addition of a peroxyl radical to the bis(thiosemicarbazone) ligand is

110 cid-catalyzed reaction of a nitroxide with a peroxyl radical to yield an oxoammonium ion followed by

111 l has more than an order of magnitude better peroxyl radical trapping activity than alpha-tocopherol

112 Plasma total peroxyl radical trapping potential values did not change

113 ycopene and vitamin concentrations and total peroxyl radical trapping potential, a measure of antioxi

114 In the first mechanism, a peroxyl radical undergoes successive 5-exo cyclizations

115 PFL was mixed with oxygenated solution, the peroxyl radical was also observed at 10 ms but in this c

116 thanol were shown to be potent scavengers of peroxyl radical, being 5.94 to 26.08 times more potent a

117 ng from C1'-hydrogen atom abstraction by the peroxyl radical, could not be detected.

118 irreversible step, subsequent to forming the peroxyl radical, is also discussed in the context of the

119 due to reaction with the enzyme-bound lipid peroxyl radical, rather than impairment of (13S)-HPODE-d

120 PPH and ABTS), reactive oxygen species (ROS; peroxyl radical, superoxide radical, hypochlorous acid),

121 lipid peroxidation is the propagation of the peroxyl radical, where generally two types of reactions

122 lipid peroxidation is the propagation of the peroxyl radical, where generally two types of reactions

123 l radical yields a strand break containing a peroxyl radical, which initiates opposite strand cleavag

124 gen atom and the internal oxygen atom of the peroxyl radical, which is nominally better for the more

125 cells, fibroblasts and lymphocytes) against peroxyl radical-induced apoptosis, necrosis and mitotic

126 ay, which measures antioxidant inhibition of peroxyl radical-induced oxidations and is a measure of t

127 Furthermore, since the assay has a Q(10) for peroxyl radical-scavenging of about 3, elevation of the

128 of H(2)B-PMHC consistent with unprecedented peroxyl radical-trapping activity in lipid bilayers.

129 formed after abstraction of H-9 or H-14 by a peroxyl radical.

130 results support formation of a transient SOD-peroxyl radical.

131 al (g = 2.034, 2.007) is characteristic of a peroxyl radical.

132 ed selectively by the 5S-diastereomer of the peroxyl radical.

133 ne results in the accumulation of the carbon peroxyl radical.

134 ogen-atom transfer (HAT) from a donor to the peroxyl radical; (b) peroxyl radical addition (PRA) to a

135 ogen-atom transfer (HAT) from a donor to the peroxyl radical; (b) peroxyl radical addition (PRA) to a

136 umn fractions permitted the determination of peroxyl-radical-scavenging profiles, demonstrating the r

137 established rate constants for reaction with peroxyl radicals (k(H-tocopherol) = 3.5 x 10(6) M(-1) s(

138 highly reactive toward phospholipid-derived peroxyl radicals (k(inh) = 2 x 10(5) M(-1) s(-1)), equal

139 eaction between nitric oxide (*NO) and lipid peroxyl radicals (LOO*) has been proposed to account for

140 the transformation, that only the 12- and 8-peroxyl radicals (those leading to 12-HPETE and 8-HPETE)

141 ensitive fluorescent probes shows that lipid peroxyl radicals accumulate at the bacterial cell poles

142 Here, the reaction between linoleate peroxyl radicals and *NO was examined using 2, 2'-azobis

143 with more lipophilic compounds trapping two peroxyl radicals and more hydrophilic compounds trapping

144 own to undergo an irreversible reaction with peroxyl radicals and other radical oxidants to generate

145 romise between H-atom transfer reactivity to peroxyl radicals and stability to one-electron oxidation

146 romise between H-atom transfer reactivity to peroxyl radicals and stability to one-electron oxidation

147 he ability of NO to react with lipid-derived peroxyl radicals and terminate the propagation of lipid

148 trolled reactivity between the RTA and lipid-peroxyl radicals and/or the potential limitations on RTA

149 e short-lived organic species are similar to peroxyl radicals appears most consistent with our experi

150 The reactions of peroxyl radicals are at the center of the oxidative degr

151 Gas phase peroxyl radicals are central to our chemical understandi

152 The reactions of organoboranes with peroxyl radicals are key to their use as radical initiat

153 (5) Lipophilic peroxyl radicals are scavenged with the same efficiency

154 Nucleobase peroxyl radicals are the major reactive intermediates fo

155 r substitutes since they often do not employ peroxyl radicals as the oxidant and do not account for b

156 from the liposome oxidations that linoleate peroxyl radicals at different positions on the eighteen-

157 inary work, we showed that TEMPO reacts with peroxyl radicals at diffusion-controlled rates in the pr

158 der these conditions wastage reactions among peroxyl radicals become important, and this translates i

159 t of cells with scavengers of superoxide and peroxyl radicals blocked adriamycin-induced oxidation of

160 The quenching of peroxyl radicals by ortho-(alkyltelluro)phenols occurs b

161 By changing the [O2]/[I] ratio, we show that peroxyl radicals can be detected and quantified preferen

162 n: polyunsaturated fatty acid (PUFA)-derived peroxyl radicals can undergo an intramolecular H-atom tr

163 iterature data for reactions of phenols with peroxyl radicals clearly reveals that diarylamines have

164 xidation, and the carbon[bond]oxygen BDEs of peroxyl radicals correlate with rate constants for beta-

165 measurements of the reactions of RSeOH with peroxyl radicals demonstrate that it readily undergoes H

166 e modifications at guanines and cytosines by peroxyl radicals depends on the exact specification of 5

167 -classical" RTA activity, where they trap >2 peroxyl radicals each, at ambient temperatures.

168 to different rates of beta-fragmentation of peroxyl radicals formed from oxygen addition at differen

169 e oxidation of organic amines by NH2Cl and N-peroxyl radicals from the reaction of aminyl radicals wi

170 eroxidizing arachidonic acid (20:4omega6) or peroxyl radicals generated by thermolysis of ABIP in the

171 minary applications include the detection of peroxyl radicals generated thermally in soybean phosphat

172 from Ch occurs at C7, although HA from C4 by peroxyl radicals has recently been observed.

173 tions of linoleate in which the C-9 and C-13 peroxyl radicals have similar reactivities.

174 activities of lipophilic antioxidants toward peroxyl radicals in a lipophilic medium (octane:butyroni

175 nic solutions of different polarity and with peroxyl radicals in a micellar system mimicking the amph

176 ne (kinh = 3.8 x 10(4) M(-1) s(-1)) and four peroxyl radicals in acetonitrile (kinh = 9.5 x 10(3) M(-

177 al and prevent macrophage lysis, implicating peroxyl radicals in both mitochondrial dysfunction and m

178 1) in acetonitrile, and honokiol trapped two peroxyl radicals in chlorobenzene (kinh = 3.8 x 10(4) M(

179 ndicate that the rate of production of lipid peroxyl radicals in HeLa cells under basal conditions is

180 ties of the pyridinols toward chain-carrying peroxyl radicals in homogeneous organic solution were ex

181 s a good scavenger of hydroxyl, alkoxyl, and peroxyl radicals in homogeneous systems.

182 and the polarity of the local environment of peroxyl radicals in liposomal oxidations depends on the

183 have mapped oxidative base damage induced by peroxyl radicals in the supF tRNA gene and correlated th

184 We find that the intermediate peroxyl radicals in these cases have negative C[bond]OO*

185 Detection of photochemically produced peroxyl radicals is achieved by employing 3-amino-2,2,5,

186 nce intensity enhancement upon reaction with peroxyl radicals is reported.

187 her than expected reactivity of RSeOH toward peroxyl radicals is the strongest experimental evidence

188 us micelles, with rate constant for trapping peroxyl radicals kinh=(3.8 +/- 0.7) x 10(4)M(-1)s(-1) at

189 ced by traditional assays, and inhibited the peroxyl radicals mediated oxidation of a tryptophan-cont

190 ompounds 9-11 quenched linoleic-acid-derived peroxyl radicals much more efficiently than alpha-tocoph

191 We propose that cellular lipid peroxyl radicals or lipid hydroperoxides induce an apopt

192 bservation of steady concentrations of lipid peroxyl radicals produced in live cell imaging condition

193 Perflubron did not serve as a sink for peroxyl radicals produced in the aqueous phase during se

194 Each molecule trapped a number n of peroxyl radicals ranging from 4 to 7.

195 Scavengers of peroxyl radicals restore mitochondrial membrane potentia

196 tom transfer from pzH to alkyl, alkoxyl, and peroxyl radicals reveals that BDEs are not a good predic

197 (4) Lipophilic peroxyl radicals show reduced discrimination between ant

198 provides a steady source of free amphiphilic peroxyl radicals that efficiently initiates oxidation of

199 )): the reduced form, ubiquinol, traps lipid peroxyl radicals that mediate lipid peroxidation, wherea

200 explained by the addition of intermediate 5'-peroxyl radicals to the C8 position of the attached puri

201 gen incorporation on their reactivity toward peroxyl radicals was comparatively small (a decrease of

202 reactivity of DNA bases toward oxidation by peroxyl radicals was found to be G >> C > T.

203 f dialkylamino-substituted diarylamines with peroxyl radicals were found to be >10(7) M(-1) s(-1), wh

204 Peroxyl radicals were generated with 2,2'-azobis(2-methy

205 ary orbital interactions in the reactions of peroxyl radicals with good H-atom donors.

206 mined the DNA damage produced by reaction of peroxyl radicals with human fibroblast DNA.

207 utoxidations, CuATSM reacts with THF-derived peroxyl radicals with k(inh) = 2.2 x 10(6) M(-1) s(-1) r

208 data for reactions of the diarylamines with peroxyl radicals with literature data for reactions of p

209 dimethylisovaleronitrile) (AMVN) to generate peroxyl radicals within cellular membranes of HL-60 cell

210 group on the chromanol group can trap lipid peroxyl radicals within the interior and near the surfac

211 hydrogen peroxide, peroxynitrite anions, and peroxyl radicals) were measured with an amine-reactive g

212 ition of DNA damage (induced by hydroxyl and peroxyl radicals), copper-induced LDL-cholesterol peroxi

213 peroxidation induced by an azo-initiator of peroxyl radicals, 2, 2'-azobis(2,4-dimethylvaleronitrile

214 cause of its far superior reactivity towards peroxyl radicals, 7-DHC effectively shields (phospho)lip

215 H2B-QH2 is shown to react with peroxyl radicals, a form of reactive oxygen species (ROS

216 ienyl radicals; (3) disproportionation of 10 peroxyl radicals, and (4) unimolecular decay of nine per

217 iologically relevant reactions of ascorbate, peroxyl radicals, and alpha-tocopherol.

218 ent and cyclization of allyl and pentadienyl peroxyl radicals, and homolytic substitution of carbon r

219 d superoxide anion, peroxynitrite anion, and peroxyl radicals, but with different efficiencies; furth

220 We review the thermochemistry of the peroxyl radicals, CH(3)OO and CH(3)CH(2)OO.

221 s in spinach extracts provided resistance to peroxyl radicals, components that did not bind to the HP

222 mulgel showed that in addition to inhibiting peroxyl radicals, curcumin and curcumin esters were like

223 The in vitro antioxidant capacity against peroxyl radicals, DPPH, and sulfhydryl groups were analy

224 M) and is sensitive to the presence of lipid peroxyl radicals, effective chain carriers in the lipid

225 ing processes, including reaction with lipid peroxyl radicals, erythrocytes and superoxide ions, were

226 e constants for H-atom transfer reactions to peroxyl radicals, greatly enabling the kinetic and mecha

227 oxidant capacities of 2c, 2f, and 2p against peroxyl radicals, hydroxyl radicals, superoxide anion, s

228 .6, and the rate constants for reaction with peroxyl radicals, k(inh), are 1200 and 3300 M(-1) s(-1)

229 )(TOH), is ~8 in the presence of hydrophilic peroxyl radicals, regardless of the nature of the lipid

230 The respective peroxyl radicals, resulting from O2 trapping, add to 5'-

231 erates free radical intermediates (primarily peroxyl radicals, ROO(*)) and electrophilic aldehydes as

232 nglet oxygen leads to hydroperoxides then to peroxyl radicals, tetraoxides, and decomposition product

233 pite their remarkably high reactivity toward peroxyl radicals, the phenoxazines were found to be comp

234 cs, scavenging activity against hydroxyl and peroxyl radicals, the reducing power and chelating capac

235 nt radicals, including the hydroxyl radical, peroxyl radicals, the trioxidocarbonate radical anion, n

236 xidative stress is the reactivity of RSSH to peroxyl radicals, where favorable thermodynamics are bol

237 gamma-Tocopherol scavenges lipid peroxyl radicals, while phenolics donate hydrogen atoms

238 and styrene at 303 K, magnolol trapped four peroxyl radicals, with a kinh of 6.1 x 10(4) M(-1) s(-1)

239 one molecule of DA traps approximately four peroxyl radicals, with a rate constant k(inh) >10(3) M(-

240 presence of either hydrophilic or lipophilic peroxyl radicals.

241 ts and their scavenging capacity on DPPH and peroxyl radicals.

242 ibits apoptosis by scavenging cellular lipid peroxyl radicals.

243 des, we derive the heats of formation of the peroxyl radicals.

244 he individual extract components to scavenge peroxyl radicals.

245 s free radicals, particularly oxygen-derived peroxyl radicals.

246 humans as they scavenge molecular oxygen and peroxyl radicals.

247 yl radicals transform into the corresponding peroxyl radicals.

248 and torularhodin were most effective against peroxyl radicals.

249 tects the bacterial cell envelope from lipid peroxyl radicals.

250 pyrylium was more effective inhibiting lipid peroxyl radicals.

251 radicals, and (4) unimolecular decay of nine peroxyl radicals.

252 tal dG's are also oxidatively damaged by the peroxyl radicals.

253 ence for electron transfer by the nucleobase peroxyl radicals.

254 quent trapping by O2 leads to the respective peroxyl radicals.

255 heir reactivity toward H-atom abstraction by peroxyl radicals.

256 e suspensions with hydrophilic or lipophilic peroxyl radicals.

257 -TO. radical reacts with lipid to form lipid peroxyl radicals. (2) Phase transfer: alpha-TOH can tran

258 pids do not efficiently scavenge hydrophilic peroxyl radicals; under these conditions wastage reactio

259 y reacting with them, the resulting protein (peroxyl) radicals can oxidize the bound DNA.

260 ditions suggests an enrichment in the use of peroxyl scavenging acids in the proteins used to sustain

261 Nonetheless, the peroxyl scavenging activity remained unaltered, likely,

262 omposition and antioxidant potential towards peroxyl, superoxide and hydroxyl radicals.

263 c product and beta-fragmentation of the same peroxyl that gives the trans,trans-product hydroxyoctade

264 ocess involving beta-fragmentation of the 15-peroxyl would give racemic isoprostane products.