ライフサイエンスコーパス: persistently

1 the population's polymer mass will increase persistently.

2 ated Na(+) channels and enables them to open persistently.

3 cts precisely paralleled previous reports of persistently (~10 min) increased cytosolic [Ca(2+)] with

4 ologically distinct disorders that result in persistently abnormal kidney structure and/or function,

5 rnative "notch-pre-patterns-growth" model, a persistently acting growth regulator whose distribution

6 ROR1 forms a functional complex with CD19 to persistently activate the key cell signaling pathways PI

7 t overlapping VMHdm(SF1) subpopulations were persistently activated by different modalities of threat

8 ells, poly (ADP ribose) polymerase (PARP) is persistently activated by unrepaired DNA damage and cons

9 (PH) is characterized by the accumulation of persistently activated cell types in the pulmonary vesse

10 However, S6 was persistently activated despite suppression of AKT.

11 hat in hypercaloric diet-induced obese mice, persistently activated microglia in the MBH hypersecrete

12 the high expression of genes involved in the persistently activated phenotype of PH vascular cells is

13 Visually selective cells can remain persistently active for several seconds, thereby reveali

14 H3 profiling (DBP) identifies drugs that are persistently active in BH3 mimetic-resistant myeloblasts

15 e key area of endogenous pain modulation, is persistently active in normal conditions to maintain an

16 Persistently active neurons are thought to be a mechanis

17 We show that memoranda-selective persistently active neurons in the human medial temporal

18 edback-mediated competition between multiple persistently active neurons reproduces this phenomenon.

19 nance of multiple items in WM that relies on persistently active neurons whose activation is orchestr

20 sensorimotor model that distinct isoforms of persistently active protein kinase Cs (PKMs) maintain di

21 The Jovian moon Io hosts the most powerful persistently active volcano in the Solar System, Loki Pa

22 Here, we identify pCd neurons as persistently active, indirect P1 targets that are requir

23 However, P1 neurons themselves are not persistently active.

24 ep, and financial problems were severely and persistently affected.

25 alpha2delta4, which was augmented early and persistently after pilocarpine-induced SE.

26 matory genes were also upregulated early and persistently after TBI.

27 e, HIV infection or exposure, low CD4 levels persistently alter the oral microbiota during this criti

28 whether localized S. aureus skin infections persistently alter the resident Mphi subset composition

29 In summary, cocaine exposure persistently alters gene expression profiles and electro

30 primarily of neuroendocrine cells, which are persistently and commonly activated by multiple classes

31 formed using a DNA adapter, moved slowly and persistently, and blocking p150 led to a 70 nm/s plus-en

32 These evolutionary transitions are persistently associated with convergent phenotypes, wher

33 years or older with systolic blood pressure persistently at or above 150 mm Hg to achieve a target s

34 estimates between remembered positions were persistently biased, revealing distorted memory maps tha

35 cancer cells with EGFR and STAT3 inhibitors persistently blocks EGFR and STAT3 signaling, and exerts

36 rds opened for adults decreased abruptly and persistently by 13.4% (95% CI, -16.0% to -10.8%; P < .00

37 sformed, metastatic cancer cells can migrate persistently by adapting (plasticity) to changes in the

38 from mice 1 month after SEFL and identified persistently changed microRNAs, including mir-135b-5p, a

39 ror task, that population activity in PFC is persistently changing, regardless of learning.

40 However, subjects in the stimulation group persistently chose those cues, even though devaluation o

41 culated into naive wild-type (WT) mice, this persistently circulating CHIKV strain displayed a capaci

42 ment (NaVAb/FY: T206F and V213Y) generates a persistently closed form of the activation gate in which

43 opulation is asymptomatically, naturally and persistently colonised by Staphylococcus aureus.

44 ify a single strain of S. aureus found to be persistently colonising the gastrointestinal tract of BA

45 Its ability to persistently colonize the intestinal tract of a broad ra

46 y to 3D4/31 cells; however, it was unable to persistently colonize the nasal cavity of inoculated pig

47 dents screened during multiple PPSs remained persistently colonized with C. auris.

48 ter pylori is a gram-negative bacterium that persistently colonizes the human stomach by inducing imm

49 ectively treated AAA patients was stable and persistently compromised [4-year relative survival and 9

50 ta suggest that early-life tissue damage may persistently constrain the ability of spinal DYN interne

51 ow to high inflammatory potential of diet or persistently consumed a proinflammatory diet had greater

52 itioning mechanisms in artificial cells with persistently contracting actomyosin networks, generated

53 e found that a history of alcohol dependence persistently decreased the expression of Prdm2, a histon

54 n (Q(10)) in a temperate grassland ecosystem persistently decreases by 12.0 +/- 3.7% across 7 years o

55 tor of cellular necroptosis, was rapidly and persistently degraded by the minimally passaged HCMV str

56 partially restored in remyelinated, but not persistently demyelinated, lesions.

57 In persistently depolarized beta cells from KATP channel kn

58 Persistently depolarizing sodium (Na(+)) leak currents e

59 eas DA terminals in other NAc subregions are persistently depressed.

60 Pase activity by locking the ROC domain in a persistently dimeric state.

61 vioral control over an aversive stimulus can persistently diminish threat responses, and that these e

62 1 critically ill patients with COVID-19 with persistently diminished mental status who underwent MRI

63 nce may be more effective than extinction in persistently diminishing threat responses.SIGNIFICANCE S

64 at the H2A-H2B interface of nucleosomes and persistently displaces DNA from the surface of H2A-H2B.

65 ng sites to scaffold proteins, Ca(V)2.1(+47) persistently displayed higher mobility within nanodomain

66 sis is that the INR phenotype is caused by a persistently disrupted mucosal barrier, but assessments

67 lly, we show that synaptic activity blockade persistently down-regulates miR-186-5p.

68 g Scn5a (Nav1.5) and Gja5 (connexin 40), are persistently downregulated long after a transient Notch

69 urse studies revealed that cocaine treatment persistently downregulated miR-124 in NAc.

70 This highlights the persistently dramatic impact of SCA on STEMI and the maj

71 all increased within a 2000 yr period from a persistently dry state to an active convective regime at

72 RNA construct was sufficient to markedly and persistently elevate ingestive behavior and body weight

73 The persistently elevated analytes with good correlation bet

74 aggerated remote contextual fear, as well as persistently elevated anxiety-like behavior and impaired

75 worse clinical outcomes, and trajectories of persistently elevated biomarkers of host injury and infl

76 nitial phenotyping, the high-BI group showed persistently elevated freezing during a 30-min 'recovery

77 Stressed animals displayed persistently elevated freezing during extinction.

78 Lamina propria CD20 cells were persistently elevated in all 3 Giardia-exposed groups.

79 Chemokines Ccl5 and Ccl8 were persistently elevated in inflamed islets and the influx

80 yond the period of exposure to MALP-2 and is persistently elevated in mycoplasma infected cells.

81 individuals with incident TB while remaining persistently elevated in those who died.

82 Persistently elevated intracranial pressure (ICP) above

83 lling for relevant covariates, we found that persistently elevated leukocyte trajectories were not as

84 n type 9 (PCSK9) inhibitors in patients with persistently elevated low-density lipoprotein cholestero

85 ND PET) and b) repeat PSMA-PET performed for persistently elevated PSA level (>=0.1 ng/mL) >=6 weeks

86 LND PET) and repeat PSMA PET performed for a persistently elevated PSA level (>=0.1 ng/mL) at least 6

87 injury, and urologic obstructive disorders), persistently elevated renal TGF-beta1 levels result in t

88 y global REV-ERBalpha deletion, which caused persistently elevated synaptic phagocytosis.

89 15 years, required chronic transfusions for persistently elevated TCD velocities, and had at least 1

90 SCA requiring chronic transfusion because of persistently elevated TCD velocities, MSD-HSCT was signi

91 of nigrostriatal dopamine axons rapidly and persistently elevated the excitability of D1 receptor-ex

92 This chronic ISR program is characterized by persistently elevated uORF mRNA translation and concurre

93 clinically recognized events had dynamic or persistently elevated values and were at high risk of re

94 ortuosity following IVB may be indicative of persistently elevated vascular endothelial growth factor

95 scribes "a distinct period of abnormally and persistently elevated, expansive, or irritable mood and

96 We quantify persistently elevated, intermittent, and extreme concent

97 unstable or less active when lysosomal pH is persistently elevated.

98 CD25 represents an improved IL-2 analog that persistently elevates Tregs to maintain a favorable Treg

99 activity-dependent intrinsic plasticity that persistently eliminates the burst firing potential of Re

100 etwork properties differ from S1, wherein S2 persistently encodes cued recall and the stimulus catego

101 RSC flexibly changes its history coding and persistently encodes value-related signals to support ad

102 chanisms to detect and destroy proteins that persistently engage the translocon.

103 timescales, geomagnetic secular variation is persistently enhanced in the vicinity of Saint Helena.

104 aracteristics in a subset of mice, including persistently enhanced memory and heightened cFos in the

105 ptogenetics, they show that dopamine release persistently enhances the intrinsic excitability of dire

106 We find a persistently enriched gastrointestinal antibiotic resist

107 The cell can migrate persistently even if its cortical contraction cannot def

108 shington D.C., where the black-white gap has persistently exceeded 10 years.

109 aviorally too, unmated males but not females persistently exchanged mild punishments in return for so

110 w that force lengthens kinetochore-fibers by persistently favoring plus-end polymerization, not by in

111 moment fragments into an ordered part and a persistently fluctuating one.

112 nsive global research efforts have therefore persistently focused on bleaching phenomena to understan

113 unfavorable long-term disease trajectory and persistently frequent severe exacerbations need to be id

114 depression (+1 point) was predictive of the "persistently frequent" trajectory (area under the receiv

115 to survive cyclical uterine tissue loss and persistently generate all endometrial epithelial lineage

116 lateral attachment of the second sister can persistently generate this metaphase-like tension before

117 and 0.58 [95% CI, 0.36-0.94] for uninsured) persistently had lower rates of hypertension control com

118 Children who were persistently heavy at ages 7 and 13 years and children w

119 ns observed in real-world phenomena might be persistently hidden.

120 rhagic ovaries that are thought to be due to persistently high circulating levels of LH from the pitu

121 lar signal-regulated kinase (ERK), mTOR, and persistently high cyclic AMP (cAMP) signaling, suggestin

122 Pressure ulcer rates are persistently high despite years of research and practice

123 Conclusion The findings demonstrate persistently high detection rates of high-grade DCIS in

124 Persistently high fat mass during adolescence was associ

125 k of HCC was the highest in patients who had persistently high FIB-4/APRI and both with and without c

126 tivity-dependent Cl- loading, resulting in a persistently high intraneuronal Cl-.

127 ested in particular that children exposed to persistently high levels of maternal depressive symptoms

128 In vitro, ISG15 deficiency also leads to persistently high levels of type I IFN-stimulated gene e

129 pEF)-remain difficult to treat, resulting in persistently high morbidity and mortality in the majorit

130 ill poses a formidable clinical threat, with persistently high morbidity and mortality.

131 I during hospitalization was associated with persistently high NGAL levels, and NGAL was an independe

132 Persistently high octocoral recruitment provides a mecha

133 PSMA response heterogeneity was noted, with persistently high or increasing SUV(max) in 37.5% (3/8)

134 The exercise demonstrates the persistently high prevalence of African mothers who have

135 The persistently high prevalence of late-stage breast cancer

136 duces recall for assessment and demonstrates persistently high sensitivity and negative predictive va

137 ac disease confirmed by intestinal biopsy or persistently high tissue transglutaminase autoantibody l

138 Persistently high total FMI and trunk FMI between ages 9

139 After the chronic phase, IL-33 levels were persistently high, and rhinovirus challenge exacerbated

140 t ages 6 years; n=72 at young adulthood) had persistently higher rates than UK controls of symptoms o

141 lanning in vivo studies seeking to eliminate persistently HIV-1-infected cells.

142 specific binding against native antigens on persistently HIV-infected cells and recombinant antigens

143 nate cellular response from 2 to 14 weeks in persistently IGRA-negative contacts but not converters.

144 cterial stimuli, but compared to converters, persistently IGRA-negative contacts produced more proinf

145 territory available, oligodendrogenesis was persistently impaired in deeper cortical layers that exp

146 iographic signal regions showed transient or persistently improved fluorescein angiographic signal (1

147 le cells group into a collective and migrate persistently in a directed manner.

148 phorylated, indicating activation, early and persistently in AT and AT MDCs of wild-type mice fed a h

149 cient to cause ASD-like phenotypes early and persistently in male offspring.

150 6 um), unexpectedly, elongated cells migrate persistently (in 1 dimension) at high speeds in 3-dimens

151 Persistently increased activity of G protein-coupled rec

152 ansive, or irritable mood and abnormally and persistently increased activity or energy" as a primary

153 Spine motility was persistently increased in the BLA, but not in CA1.

154 not choose a surgical treatment resulting in persistently increased postsurgical disability, even if

155 5 weeks after IRI, which was associated with persistently increased renal infiltrates of mononuclear

156 Persistently increased urinary phosphate excretion maint

157 Meanwhile, ozonated CBZ persistently induced embryotoxicity over 2 week storage,

158 lating nuclear responses that permit ZIKV to persistently infect hBMECs and thereby gain access to ne

159 cycle and ISG responses that permit ZIKV to persistently infect hBMECs.

160 and cell cycle responses that permit ZIKV to persistently infect hBMECs.IMPORTANCE ZIKV is a unique n

161 Human cytomegalovirus (HCMV) can persistently infect humans, but how HCMV avoids humoral

162 nd in salpingeal pockets and in one of three persistently infected animals inoculated only in the cer

163 t tissues was not detected, even among three persistently infected animals.

164 te successful transmission of the virus from persistently infected animals.IMPORTANCE Persistent vira

165 s, and disrupting the interferon response in persistently infected bat cells increased virus replicat

166 sequencing the whole genome of MERS-CoV from persistently infected bat cells, we identified that bat

167 We carried out studies in FMDV SAT1 persistently infected buffaloes to characterize the dive

168 sile aggregates, or in vivo biofilms, in the persistently infected C. elegans gut.

169 Importantly, persistently infected carrier animals shedding SVA in or

170 t cleared infection versus those that became persistently infected carriers.

171 ts, along with the establishment of a unique persistently infected cell culture model to study MERS-C

172 We characterized the persistently infected cells by detecting virus particles

173 ed with emerging immunotherapeutics to clear persistently infected cells will soon allow measurable c

174 sensus on how best to measure the numbers of persistently infected cells with the potential to cause

175 e preferentially expressed at the surface of persistently infected cells.

176 selection were continually recruited to the persistently infected CNS.

177 th reduced TCR diversity compared to that of persistently infected control mice (Shannon indices of 2

178 CDR3 motif than those of top clonotypes from persistently infected control mice.

179 ore, MUP production was not elevated in v2.2 persistently infected mice unless virus was cleared foll

180 However, some of these MCMV persistently infected mice with acute LCMV infection (7

181 ed mice lost control of virus replication in persistently infected mice.

182 ificantly ameliorate LD-induced arthritis in persistently infected mice.

183 non indices of 4 in immunized mice to 2.6 in persistently infected mice.

184 ntly reduce the pathology of LD arthritis in persistently infected mice.

185 racterization of host responses in acute and persistently infected patients.

186 ct of SVA infection biology, suggesting that persistently infected pigs may function as reservoirs fo

187 further, we isolated CHIKV from the serum of persistently infected Rag1 (-/-) mice at day 28.

188 enced by successful transmission of SVA from persistently infected sows to contact piglets.

189 he fact that contact piglets (11/44) born to persistently infected sows were infected by SVA, demonst

190 ed one genotype 1a infection and then became persistently infected with a second genotype 1a strain.

191 Furthermore, bat cells that were persistently infected with DeltaORF5 MERS-CoV were resis

192 naling in humanized mice (hu-mice) that were persistently infected with HIV-1.

193 among HIV-positive women, the odds of being persistently infected with hrHPV was higher in women wit

194 avirus infection model of bat cells that are persistently infected with MERS-CoV.

195 gen, with over 80% of adults worldwide being persistently infected.

196 NAs consistent with a targeted processing of persistently infecting virus genomes.

197 stance, the tapeworm Schistocephalus solidus persistently infects 0-80% of threespine stickleback (Ga

198 ka virus (ZIKV) is cytopathic to neurons and persistently infects brain microvascular endothelial cel

199 KV is a unique neurovirulent flavivirus that persistently infects human brain microvascular endotheli

200 in tissues, including those occurring in the persistently inflamed central nervous system (CNS).

201 o-occurring fungal and bacterial communities persistently influenced one another independently from t

202 riven cancer, the SMAP treatment rapidly and persistently inhibited MYC expression through proteasome

203 n circulating catecholamines in IUGR fetuses persistently inhibits insulin concentrations and secreti

204 In contrast, aggregated endodermal cells persistently lose epithelial features.

205 rogenase and aspartate aminotransferase were persistently low (lactate dehydrogenase < 100 U/L, below

206 with human immunodeficiency virus (PWH) with persistently low CD4 counts despite efficacious antiretr

207 iopathic CD4 lymphopenia (ICL) is defined by persistently low CD4+ cell counts (<300 cells/muL) in th

208 Factors affecting persistently low densities of generalist carnivores and

209 the intestinal microbiota, characterized by persistently low diversity, dominance of pathogenic bact

210 r pH-that show that the ocean surface pH was persistently low during the PETM.

211 Compared with participants with persistently low EDIP scores (at 2 time points, separate

212 on of genes associated with T(FH) cells, but persistently low expression of genes associated with T(H

213 llergy and autoimmunity were associated with persistently low immunoglobulin M levels and lymphopenia

214 xposure to NO(2) at birth is associated with persistently low levels of CC16 from 6 to 32 years.

215 Despite persistently low MELD-Na scores, patients with cirrhosis

216 Despite persistently low MELD-Na scores, patients with cirrhosis

217 In multivariable models, compared with the persistently low pain trajectory, there was a dose-depen

218 r cells were unrelated to organ dysfunction, persistently low respiration was associated with slower

219 Persistently low spare respiratory capacity was predicti

220 n patients with <=1:5 titers (n = 21) showed persistently low titers in 6 of 12 instances and increas

221 Persistently low TSH concentrations at 1 year after diag

222 neralist carnivores, and piscivores remained persistently low with little indication of recovery seve

223 orted pain trajectories were identified: (1) persistently low, (2) mild, (3) moderate or (4) high tra

224 za in people with asthma, but uptake remains persistently low, partially reflecting concerns about va

225 za in people with asthma, but uptake remains persistently low, partially reflecting concerns about va

226 adherence to dietary guidelines has remained persistently low.

227 Hypertension control was persistently lower for blacks than for whites of all age

228 HbA1c concentrations were persistently lower in the sacubitril/valsartan group tha

229 function were independently associated with persistently lower lung function months after TB treatme

230 t the adult life span the female brain has a persistently lower metabolic brain age-relative to their

231 Evolocumab + SOC persistently lowered mean +/- SE low-density lipoprotein

232 nd CKD (estimated glomerular filtration rate persistently <60 mL/min/1.73 m2 for >=90 d using the mod

233 finely tuned, content-specific attractors to persistently maintain neural activity and therefore do n

234 ere compared with a control group of ECs who persistently maintained virological control during the s

235 with biochemical persistence (BCP; that is, persistently measurable prostate-specific antigen [PSA]

236 o elicit half of the phagocytes to associate persistently (MOP(50)) is determined first.

237 gnoses of Shigella infections in England are persistently most common in adult males without a report

238 levance and the potential prognostic role of persistently negative (1,3)-beta-D-glucan (BDG) in adult

239 In this context, the appropriate use of persistently negative BDG results could be an aid to ind

240 Candidemic patients with persistently negative BDG tests present a better prognos

241 In the multivariate analysis, persistently negative BDG tests were independently assoc

242 verall, 26/148 (17.6%) candidemic adults had persistently negative BDG tests.

243 up vs 93.4 in positive group; P = .599), the persistently negative group had a higher rate of microbi

244 as equally provided to both groups (96.2% in persistently negative group vs 93.4 in positive group; P

245 re measured for early clearers, defined as a persistently negative IGRA at 3 months, and converters,

246 Early clearance was defined as a persistently negative IGRA.

247 dults from a TB household contact study with persistently negative TST (PTST-) or with stable latent

248 tuberculosis (M.tb) infection, identified by persistently negative tuberculin skin tests (TST) and in

249 s were IGRA converters; 317 (71.2%) remained persistently negative.

250 Patients with hepatic steatosis with persistently normal ALT are at lower risk for cirrhosis

251 ich is the main target species but cannot be persistently overfished due to a specific prohibition on

252 We found a specific signature of persistently phosphorylated tyrosine peptides after the

253 onstitutive CaMKII activation, which in turn persistently phosphorylates Tiam1.

254 mplicated bacteremia (community acquisition, persistently positive blood cultures, >72 h of fever, or

255 Fourteen patients remained persistently positive for HBsAg, all of whom had undetec

256 with coronavirus disease 2019 (COVID-19) had persistently positive nasopharyngeal swabs up to day 16

257 Persistently positive serology usually indicates ongoing

258 microembolus/hr; 95% CI, 1.01-1.05) and with persistently positive transcranial Dopplers over multipl

259 ocating nondeclared and illegal fisheries is persistently problematic.

260 nce between gene trees and species trees are persistently problematic.

261 CD19-BBz(86) CAR T cells persistently proliferated and differentiated into memory

262 paB, thereby instigating a vicious circle to persistently promote atherogenesis.

263 I, providing a self-reinforcing mechanism to persistently promote nociceptor hyperexcitability and li

264 ting an unexpected positive feedback loop to persistently promote pain.

265 5 mM, and an early peak rapidly succeeded by persistently reduced [Ca(2+)] likely reflecting gradual

266 pses but, following 4 Hz stimulation, DSE is persistently reduced and recovers more rapidly.

267 CPs are regulated in vivo LTH manifests as a persistently reduced behavioral response to an odorant e

268 as polymethylmethacrylate (PMMA), which are persistently released following implant surgery evoke he

269 erformed studies with male C57BL/6 mice that persistently replicate HBV (genotype D, serotype ayw)-ei

270 emonstrates that infection with a virus that persistently replicates in the intestinal mucosa increas

271 ticipant revealed that CSF escape was from a persistently replicating population, likely in macrophag

272 ny somatic lineage programs are actively and persistently repressed by Myt1l to maintain neuronal ide

273 positories, with the goal of identifying the persistently reprogrammed signaling pathways driven by c

274 y in the first hour after fertilization, but persistently required throughout the rest of the blastod

275 ht-evoked stimulation of retinal neurons and persistently rescue visual functions when subretinally i

276 findings demonstrate that intra-accumbal ZIP persistently reverses cocaine-induced behavioral and syn

277 etection of subgenomic RNA is recommended in persistently SARS-CoV-2-positive individuals as a proxy

278 versification and disappearance suggest that persistently "selfish" machinery shapes telomere elongat

279 changes in a human's living environment can persistently shape their gut microbiota and antibiotic r

280 ding global cause of gastroenteritis, can be persistently shed during infection, but its in vivo cell

281 confidence interval, 1.64-4.28; P<0.001) or persistently so (22.5% versus 8.8%; adjusted hazard rati

282 alive/extubated(Day28)) versus those dead or persistently supported on mechanical ventilation at Day

283 ferent stages of infection, allowing them to persistently survive without being recognized by hosts a

284 P <= 0.05) and 13 proteins in patients with persistently symptomatic SA (>=twofold change; P <= 0.05

285 that there is deterioration of CA1 volume in persistently symptomatic UHR individuals in proportion t

286 it remains unknown why some patients remain persistently symptomatic.

287 Notably, eight children persistently tested positive on rectal swabs even after

288 Influenza viruses are persistently threatening public health, causing annual e

289 ew World arenaviruses from rodent reservoirs persistently threatens human health.

290 Most people report feeling persistently 'time poor'-like they have too many things

291 gle fly treadmill, we show that hungry flies persistently track a food odor and increase their effort

292 Before ART, the 31% of participants with persistently undetectable viremia had more robust HIV-sp

293 CTR and persistently unresectable cohorts differed significantly

294 ate that nigral SRY expression is highly and persistently up-regulated in animal and human cell cultu

295 P-selectin was persistently upregulated in PASMCs of human and hypoxia-

296 Persistently upregulated KLK5 resulted in AD-like skin a

297 the risk of mortality, even among people who persistently use clean fuels.

298 vations and experiments, we demonstrate that persistently warm winter soils can lead to labile C star

299 They learned to lick persistently when higher-value rewards were available an

300 onths, overall cohort performance status was persistently worse than presepsis baseline (WHO/Zubrod s