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1 en-infected cells, HLA class I expression is perturbed.
2 flexible DNA when RAD51 self-association is perturbed.
3 vidual and families of monolignol genes were perturbed.
4 out the nature of the systems that are being perturbed.
5 h T- and B-cell maturation and function were perturbed.
6 s entered the CNS, but these projections are perturbed.
7 however, as reaction kinetics are inevitably perturbed.
8 that reform their precise shape after being perturbed.
9 ration and localization in the optic cup are perturbed.
10 ly up-regulated when mitochondrial import is perturbed.
11 ensitivity syndrome involving mutations that perturb a bidirectional allosteric coupling between liga
12 itability and have tested this hypothesis by perturbing a signal transduction pathway that plays a ma
14 that the invariant aspartate of the J-domain perturbs a conserved intramolecular Hsp70 network of con
16 ses, our structures suggest that Lys73 has a perturbed acid dissociation constant (pK(a)) compared wi
18 In the disease-module network, the greatest perturbing activity was shown by nintedanib, followed by
19 eptides out of five acquired a weak membrane-perturbing activity while maintaining the ability to inh
20 tem, we show that depletion of alpha-catenin perturbs adherens junctions, enhances cell proliferation
21 ng in higher DRB expression and subsequently perturbed Ag presentation and T cell activation, higher
25 our study demonstrates the use of iterative "perturb and observe" genetic screens to uncover regulato
26 ormalization in conditions where R-loops are perturbed and for quantitative measurements that provide
27 ng framework to quantify the separability of perturbed and unperturbed cells within a high-dimensiona
30 stochasticity of subcellular Ca waves, which perturbs AP repolarization and consequently induces loca
31 suppression of ASS1 protein levels, miR-1291 perturbed arginine homeostasis and preferably sensitized
32 at the mossy fiber-granule cell synapse are perturbed, as well as the innervation of Purkinje cells
35 ation of the conserved CTD SUMOylation sites perturbs Aurora B recruitment and checkpoint activation.
36 he pre-mRNA splicing pathway, accompanied by perturbed autoregulation of canonical splicing activator
37 was significantly impaired, suggesting that perturbed autoregulation of rpl10a splicing contributes
38 MADS 79 Misregulation of MADS78 and MADS 79 perturbed auxin homeostasis and carbon metabolism, as ev
39 at a premature His complex (PHC) will always perturb AVRT because the His bundle is obligatory to the
40 CRISPR/Cas9 and shRNA techniques resulted in perturbed axonal pathfinding, delay in midline crossing,
41 s to accelerate or delay the degeneration of perturbed axons in acute and subacute rodent axon degene
42 ore, the role of excess fatty acids (FAs) in perturbing BCAA catabolism and BCKA availability merits
43 h syndrome (BTHS), in which CL metabolism is perturbed because of mutations in the CL-remodeling enzy
46 time that early life exposure to venlafaxine perturbs brain development, which may be due to reduced
48 identify regulatory elements (RE) and genes perturbed by acquired non-coding variants, here we estab
49 ponse the vascular endothelium is constantly perturbed by biologically potent molecules, including th
50 itor and neuronal maturity is differentially perturbed by cocaine, and BDNF may be required to link D
53 across studies, combined n = 133), which was perturbed by dopaminergic modulation, impaired in psycho
56 n model the complex, non-linear interactions perturbed by mutations, directly from biophysical proper
59 These cluster phenotypes were biochemically perturbed by using drugs, biasing toward traction signat
60 n both processing streams are simultaneously perturbed by violations (e.g., syntactically incorrect w
61 isruption of this precise phase relationship perturbs Ca(2+) oscillations, suggesting the relative ph
65 , T42A double mutant inhibits RanGEF without perturbing cargo binding to importin beta and disrupts M
66 o of the eight or ten hydrophobic layers are perturbed, catalytic sites can be introduced at other re
67 ng transgenic fish, and its genomic deletion perturbed caudal fin regeneration and abrogated cardiac
72 by THC in major immune cell types where THC perturbed cell-type-specific intracellular gene expressi
73 ined environments and that vimentin bundling perturbs cell-mechanical properties and inhibits the inv
75 Using these methods to analyze genetically perturbed cells, we demonstrated that genome architectur
77 at m6A loss profoundly alters these cues and perturbs cellular fate choices and tissue architecture i
78 ransient downregulation of YAP in mouse ESCs perturbs cellular homeostasis, leading to the inability
82 420H2 resulted in A/B compartment switching, perturbed chromatin insulation, and altered chromatin in
83 nce suggests that telomere dysfunctions also perturb chromosome segregation by contributing to the fo
86 mmetropization was not impacted in mice with perturbed color vision caused by intrinsic red-fluoresce
87 activity in a chromaffin cell model does not perturb complex I function, retaining the ability to oxi
88 hly heterogeneous systems in unperturbed and perturbed conditions, regardless of the availability of
91 of inputs by inactivating the thalamus; this perturbed cortical activity and disrupted limb kinematic
92 ons can impair cell fitness by significantly perturbing cotranslational protein folding mechanisms, d
94 enous KAR activity locally in the newborn LA perturbed development of glutamatergic input to CeA, ide
96 that exposure to ethanol early in gestation perturbs development of brain regions associated with mo
97 r variants reside on STF and not MTF motifs, perturbing DNA binding by various STFs (BMP/TGF-beta-dir
98 expansion of the TNR within the FRAXA locus perturbs DNA replication and is the major causative fact
100 lso maternally expressed imprinted genes are perturbed during hybridization and that such effects on
102 for prey selection, demonstrating how humans perturb ecological processes via behavioral modification
103 r the dual need to account for the potential perturbing effect(s) of antibiotic treatment on the vagi
104 o approaches, which allow for predicting the perturbing effects of drug candidates on membrane protei
107 in development, which in turn contributes to perturbed emotion regulation and subsequent risk for dep
108 ignificantly smaller until 2 dpf and display perturbed enveloping layer (EVL) integrity and cell prot
109 Maternal-zygotic mutants of mondoa showed perturbed epiboly with low penetrance and compensatory c
110 erappreciated posttranslational modification perturb epitope affinity for two groups of widely used m
111 t the inorganic lattice is not significantly perturbed even though the layer-to-layer spacing increas
112 plasticity-associated marker expression, and perturbed excitatory/inhibitory currents in the hippocam
113 ng F29, we engineered a sensitive, minimally-perturbing fluorescence-resonance-energy-transfer (FRET)
114 strand-displacement reactions whilst barely perturbing forward reaction rates: the introduction of m
116 ecules that interact with RNA structures can perturb function, serving as chemical probes and lead me
120 mutations in personal cancer genomes, which perturb gene regulation by altering chromatin architectu
121 d specific subsets of conductances that when perturbed generate similar behavior in diverse individua
124 r steps of glycosphingolipid production also perturb GlcCer transport to a greater extent than PC tra
125 elerates G1-phase cell cycle progression and perturbs global DNA methylation patterning in the genome
128 show that loss of tcf12 in zebrafish larvae perturbs GnRH neuronal patterning with concomitant atten
129 he proteins Reptin and Pontin, loss of which perturbs granule formation and prevents incorporation of
134 es may confer risk for ASD when functionally perturbed, however, only around 100 genes currently have
135 eper understanding of the molecular pathways perturbed in AKI is needed to identify targets with pote
139 ic spindle assembly and that this process is perturbed in cancer cells in a hypoxic environment.
140 retion within pancreatic beta cells that are perturbed in Clock (-/-) and Bmal1 (-/-) beta-cell lines
141 l modification and cleavage is maintained or perturbed in different hereditary monogenic conditions a
142 ains a strict immune homeostasis, which when perturbed in genetically susceptible individuals, may le
143 genesis and organ architecture are minimally perturbed in Jag1 mutants until later stages, when ducta
146 nd RUNX2 (known tooth development genes) was perturbed in mutant cells and quite significantly for PA
149 d in controlling stomatal movements was also perturbed in rPPC1-B These findings provide direct evide
153 but not healthy participants, we observed a perturbed inhibitory effect of the dlPFC on the amygdala
154 rapidly induced tri-organellar junctions and perturbed intended membrane lipids exclusively at select
158 ts provide insights into how FOXA1 mutations perturb its function to dictate cancer progression and t
159 rovide a general technique for collating and perturbing known adversarial examples to create multiple
160 ins reduced lamellipodial actin assembly and perturbed lamellipodial architecture, as evidenced by ch
161 function is implicated in muscle wasting and perturbed lipid metabolism, speculating that both can be
165 and altered RGC neurogenesis associated with perturbed melanogenesis in the retinal pigment epitheliu
169 dy demonstrates that maternal immune insults perturb microglial phenotypes and influence neuronal fun
173 between accumulation of genomic 8-oxodG and perturbed mitotic progression in cancer cells, which can
177 antify circuit stability when simultaneously perturbing multiple conductances as a nonlinear combinat
179 s reflected by DCF/dihydroethidium staining, perturbed NAD-to-NADH and glutathione-to-glutathione dis
184 vironments, this work explores the thermally-perturbed NMR properties of water in detail by in situ M
186 ivo reveal that pioneer factors can directly perturb nucleosome structure and chromatin accessibility
187 h as the Fanconi anemia-BRCA pathway, became perturbed only after long-term culturing of infected cel
188 egrase that result in clinical INSTI failure perturb optimal magnesium ion coordination in the enzyme
191 arize these changes over the entire range of perturbed parameters, we quantified circuit output by de
192 bolic biomarkers related to treatment, infer perturbed pathways as a result of treatment and find sig
193 all RNA targeting analyses revealed the most-perturbed pathways following stroke and implied a struct
194 d ATP pathways, and gene expression of these perturbed pathways was correlated with major dysbiosis-a
195 We define subgroups of autism mutations that perturb PFC neurogenesis and are correlated to abnormal
196 studies we propose a working model in which perturbed photoreceptor states cause microglial dominant
197 is genetically challenging because mutations perturbing photosynthesis are expected to affect both em
199 f Ryk phenocopies the Wnt5a (-/-) phenotype, perturbing post-mitotic pathfinding and leading to apopt
200 important to be able to predict the bilayer-perturbing potency of hydrophobic/amphiphilic drugs cand
203 lk solution during experiments, and a way to perturb protein stability without affecting the chaperon
204 Chemical biology strategies for directly perturbing protein homeostasis including the degradation
205 his study, we demonstrate the feasibility of perturbing protein synthesis in a mouse liver by targeti
206 defines the degree of cellular toxicity and perturbs protein homeostasis, and at the same time, offe
207 isms to delay anaphase onset when Topo II is perturbed, providing additional time for decatenation.
208 nstrated with an estrone substrate, does not perturb proximate ketones, which are generally vulnerabl
210 to 50% in the long-term human graft, without perturbing repopulation and self-renewal of edited HSCs.
211 wth was restricted and redox homeostasis was perturbed, resulting in unsuppressed host oxidative burs
212 ncreased lysosomal ribosomal degradation and perturbed ribosomal subunit stoichiometry, both of which
216 adaptation (i.e., adaptation of movements to perturbed sensory feedback) emphasize the role of automa
218 ome these limitations, we introduce targeted Perturb-seq (TAP-seq), a sensitive, inexpensive and plat
222 g the maintenance period, the WM network was perturbed serially with fixed and task-neutral auditory
223 sited vaterites and the evolved calcite, the perturbed shell contains two sets of carbonate species d
225 de insights into the broader implications of perturbing starch metabolism in rice endosperm and its i
226 tabolic shift from the overall post-marathon perturbed state back to the pre-marathon metabolic state
227 f LPM differentiation by atRA or thalidomide perturbed subsequent chondrogenic differentiation in vit
230 n errors to latent sensorimotor memories, we perturbed target locations to remove or enforce task err
231 flow rates from 70 to 200 nL/min and did not perturb the capillary electrophoresis separation electro
235 Here, we use femtosecond-laser ablation to perturb the dendritic input of proteins to chemosensory
237 tematically study how variations in sequence perturb the folding energy landscapes of three model seq
238 ble solutes such as glycine betaine does not perturb the functioning of cytoplasmic components, but r
244 ious work using a visual impulse stimulus to perturb the memory network has implicated such silent st
245 at blunts carcinoma initiation, but does not perturb the normal pregnancy-induced epigenomic landscap
246 demonstrating that the cyclization does not perturb the overall conformation of backbone and key sid
248 generated acoustic phonon pulses are used to perturb the QCL bandstructure, enabling fast amplitude m
249 d not affect nucleotide binding, but greatly perturbed the ability of bound nucleotide to inhibit K(A
250 simulations showed that minor groove binding perturbed the conformational dynamics and hydration at t
251 acterium Candidatus Synechococcus feldmannii perturbed the diverse microbiota associated with the hos
252 ing Sh1 growth by RNAi to cofilin and Arp2/3 perturbed the DTC-Sh1 interface, reduced germ cell proli
253 sed to a force-field that either assisted or perturbed the normal relationship between pelvis motion
255 ling the correctly aligned substrate without perturbing the equilibrium for nucleotide binding at phy
257 but also infer complex-specific functions by perturbing the gene regulatory network controlled by a s
258 be incorporated at a remote location without perturbing the heterotrimer selectivity, suggesting a un
259 whereas Mg(2+) and Cu(2+) were bound without perturbing the hydration of these functional groups.
260 F (CCCTC-binding factor) are key regulators; perturbing the levels of either greatly disrupts genome-
261 f mutations arise from cumulative effects of perturbing the network of productive and nonproductive p
262 leoli of transfected or infected cells, thus perturbing the nuclear import of transcription factors o
263 entiation and/or enhance proliferation, thus perturbing the regulatory programs that control self-ren
266 gether, we describe how lentiviral infection perturbs the oral and gastrointestinal mucosae of infant
267 ipolar cells; eliminating it in mouse retina perturbs the organization of synaptic ribbons and impair
270 er, electronic and steric effects inevitably perturb their chemical reactivity and distinguish them f
271 l molecules or protein modifications without perturbing their biological function, enabling the selec
272 llow us to probe G4s in living cells without perturbing their folding dynamics are required to unders
278 e mutants, suggesting cascading responses to perturbed thioesterification in lignin biosynthesis.
280 tions demonstrate that our designed peptides perturb TJs in human lung as well as human and murine sk
281 IE binds to TMC1/2, and a TMIE mutation that perturbs TMC1/2 binding abolishes mechanotransduction.
283 e, but the natural phosphorus cycle has been perturbed to such an extent that humanity faces two dove
285 d with wild-type but not E7 mutant virus had perturbed transcriptional regulation of pathways previou
287 +) monocytes up-regulated the top six stroke-perturbed tRFs, and overexpression of stroke-inducible t
290 soproterenol) and defined pathways that were perturbed under baseline conditions and pathways that we
291 arks developmental genes whose expression is perturbed upon experimental reduction of histone methyla
292 ll analysis of primary bone marrow revealing perturbed UPR in myeloid precursors and in vitro differe
293 ebrain excitatory knockout of Neurexin1alpha perturbed value-modulated neural signals within striatum
295 0 causes bigger pits, thinner pit membranes, perturbed vasculature development, lower reproductive po
297 (2+) efficiently and that Ca(2+) binding was perturbed when the Asp and Glu residues in the motif wer