ライフサイエンスコーパス: perturbation

1 ng of subcellular phenotypes associated with perturbation.

2 ility, mitigating effects of species loss or perturbation.

3 duced the initial in-place resistance to the perturbation.

4 preserves genome integrity under replication perturbation.

5 urface respond to a metabolic or hemodynamic perturbation.

6 proportional with the degree of inflammatory perturbation.

7 bution to the muscle responses following the perturbation.

8 ical organization, dynamics, and response to perturbation.

9 rganisms to rapidly respond to environmental perturbation.

10 ns and excitatory neurons track with sensory perturbation.

11 o external mechanical noise and cyclic force perturbations.

12 ion on dynamic cellular response to external perturbations.

13 type across genome-wide libraries of genetic perturbations.

14 the star without the expected gravitational perturbations.

15 nonlinear combination of single conductance perturbations.

16 broadband optical response and robustness to perturbations.

17 , stabilize neuronal activity in the face of perturbations.

18 st risk of failure and predict the impact of perturbations.

19 cells in monkeys responding to index finger perturbations.

20 genetic backgrounds, disease states and drug perturbations.

21 based solely on circuit output to different perturbations.

22 e responses to metabolic and pharmacological perturbations.

23 ata results through data and model/algorithm perturbations.

24 circuit solely from the circuit response to perturbations.

25 or will undergo following regulatory network perturbations.

26 he sample being studied due to low amplitude perturbations.

27 urn, may render them more vulnerable to such perturbations.

28 soil microbiomes' response to environmental perturbations.

29 rst floods were not a prerequisite for large perturbations.

30 nd to climate change and other environmental perturbations.

31 ar methods and estimations from experimental perturbations.

32 to extinction by rapidly applied additional perturbations.

33 robiome-host interactions following chemical perturbations.

34 d the transcriptional responses to direct TF perturbations.

35 usly to image interfacial water with minimal perturbation)(12), enables real-space imaging of the edg

36 variability in apparently identical genotype perturbations, 2) low-throughput electrophysiological me

37 ets captured in root cells using temporal TF perturbation account for 50% of NLP7-regulated genes not

38 ultaneous assaying of the effects of genetic perturbations across all germ layers.

39 ise a network-based approach that integrates perturbations across different molecular layers, which i

40 natures by utilizing a diverse collection of perturbations across many model systems and assay types.

41 to induce two opposite unilateral mechanical perturbations affecting the step length over multiple ga

42 tation during gait is context dependent, and perturbations altering long-term stability are compensat

43 Here, using NMR chemical shift perturbation, analytical ultracentrifugation, and native

44 ype response to various forms of replication perturbation and DNA damage in S phase, suggesting it ac

45 al deteriorations such as prolonged climatic perturbations and oceanic anoxia, related to the mass ex

46 e community are highly sensitive to temporal perturbations and spatial arrangements.

47 t advances in modeling the relations between perturbations and system function.

48 instantaneous relationship between kinematic perturbations and the resulting torque response, plays a

49 dexterity task, calcium imaging, optogenetic perturbations, and behavioral manipulations, we studied

50 gher vulnerability of the metabolic layer to perturbations applied to genes associated with metabolic

51 sed on genetic, surgical and pharmacological perturbations are being produced at an extraordinary pac

52 ficult to recognize on short time scales, as perturbations are challenging to quantify and ecosystem

53 ut the functional consequences of structural perturbations are less known.

54 est as improved adaptation when sensorimotor perturbations are reencountered.

55 r cell responses to pharmacologic or genetic perturbations are typically restricted to using simple p

56 to model the full extent of the carbon cycle perturbations around the T-J boundary.

57 on innate immunity in obesity and metabolic perturbation, as well as future directions.

58 sion of ocean anoxia and other environmental perturbations associated with these two crises. The new

59 After physical perturbation at day 7, Fe(2+) was re-mobilized reaching

60 are promising tools for multiplexed genetic perturbations because they can process multiple guide RN

61 uestion using time-lapse microscopy, genetic perturbation, bioinformatic predictions, and mathematica

62 Perturbation biology is a powerful approach to modeling

63 in biological systems, which occur when one perturbation blunts the effect of another, are typically

64 dy, we simulate single cells from TF/pathway perturbation bulk RNA-seq experiments.

65 nhomogeneous charge distribution, and due to perturbation by an external field, the high polarizabili

66 l program and confers resistance to enhancer perturbation by BRD4 inhibition.

67 enter the circulation after small intestinal perturbation by migratory helminths and move to distant

68 ng agents in linking different pathways upon perturbation by pathogen effectors.

69 facing bodies is particularly susceptible to perturbation by upside-down rotation, indicative of a pa

70 into the biochemical state of cells and its perturbations by small molecules.

71 h enables systematic exploration of cellular perturbations by tagging individual cells with RNA "barc

72 We conclude that outer membrane perturbation can be sensed by P. aeruginosa to activate

73 ergetically similar, but rational structural perturbations can be employed to break the energetic deg

74 network must include strategies to minimize perturbations caused by environmental stress, while opti

75 Genetic perturbations causing uncharged transfer RNA (tRNA) accu

76 duced larger positive after-effects once the perturbations ceased.

77 growth of new particles were observed in the perturbation chamber.

78 utline the hypothesis that cancer-associated perturbations collectively disrupt normal gene regulator

79 Raman spectroscopy with two-dimensional (2D) perturbation correlation moving window (2DPCMW) analysis

80 lethora of recent evidence derived from cell perturbation, correlative light and EM tomography, live-

81 The metabolic perturbations corroborate the observed physiological res

82 m to explore the mechanisms by which disease perturbations could cause changes in spatial organizatio

83 at can integrate gene expression and genetic perturbation data, and develop an algorithm named fused

84 Perturbations delivered while subjects were walking prov

85 Genetic and pharmacological perturbations demonstrated that PPARalpha mediates RIPK3

86 umacaftor, induces almost no transcriptional perturbation despite its rescue activity.

87 Repeated exposure to perturbations diminished this negative direct effect, an

88 In contrast, force-field perturbations directly weakened the relationship between

89 Gene perturbations disrupt morphogenesis and histo-differenti

90 These perturbations do not allow intuiting which molecular for

91 change across developmental models, genetic perturbations, drug treatments, and disease states.

92 erface that not only adapts to morphological perturbations during electrodeposition and stripping but

93 visuomotor adaptations in response to visual perturbations during overground walking and may help to

94 ith adaptation in other motor tasks, such as perturbations during reaching.

95 l coherence (ITC) and event-related spectral perturbation (ERSP) were significantly reduced at the ga

96 Analysis of a 96-plex perturbation experiment revealed changes in cell populat

97 Transcriptional perturbation experiments recapitulated the exclusion of

98 Chemical perturbation experiments suggest that mechanically evoke

99 pplied to gene sets derived from targeted TF perturbation experiments, Lisa boosted the performance o

100 knockout mouse with a disease-like molecular perturbation expressed only in hippocampal dentate gyrus

101 Free energy perturbation (FEP) has been applied to predict the effec

102 model and including a systematic free energy perturbation (FEP) study.

103 nes, a modification motivated by free energy perturbation (FEP+) calculations.

104 Structural perturbations first occur at the special pair of chlorop

105 t gene deletions or exposed to environmental perturbations, followed by converting similarities betwe

106 tions, and observe widespread chemical shift perturbations for methyl groups in Z AAT (E342K).

107 ations harness energy from nonlinear orbital perturbation forces (e.g., Earth's geopotential, gravita

108 y adopted to define specific transcriptional perturbations from gene expression signatures.

109 ts, drug physicochemical properties and drug perturbation gene expressions.

110 Data synthesis indicated that human perturbation has amplified chemical contrasts in shallow

111 ne cells coordinate tissue-wide responses to perturbation have emerged from deciphering the communica

112 ents clearly result in significant metabolic perturbations, heart failure with both preserved and red

113 yeast proteome in response to environmental perturbations, identifying distinct responses to each of

114 pically interpreted as evidence that the two perturbations impact the same cellular pathway or functi

115 This perturbation impairs sister chromosome linkage, advances

116 terial and glial activation, and has limited perturbation in behavioral measures.

117 ease in H4K20me1, but only modest (1.4-7.8%) perturbation in genome-wide expression was observed.

118 rain at high spatial resolution with minimal perturbation in living sytems.

119 Perturbation in metabolic pathways related to arginine a

120 and field to estimate the membrane potential perturbation in pyramidal cells.

121 he biological impact of chemical and genetic perturbations in cellular assay systems.

122 ernal immune activation (MIA) and identified perturbations in cellular pathways associated with mRNA

123 in mouse prefrontal cortex neurons leads to perturbations in dendritic spine development and hypocon

124 ess homeostatic mechanisms to compensate for perturbations in drive, which, in turn, may render them

125 Hearts from type 2 diabetic animals display perturbations in excitation-contraction coupling, impair

126 Lipid profiling revealed ala4/5 rosettes had perturbations in glycerolipid and sphingolipid content.

127 Perturbations in Golgi structure are associated with num

128 rate-limiting metabolic genes known to have perturbations in human metabolic disease.

129 t diets and are affected by context-specific perturbations in humans.

130 Through the understanding of the biological perturbations in individuals with NKD, requirements for

131 nd which anticipates an embryo's response to perturbations in lineage composition.

132 protein aggregation, reduced cell viability, perturbations in mitochondrial morphology and membrane p

133 Application of such single-neuron perturbations in mouse visual cortex has recently reveal

134 , characterized by extensive gene expression perturbations in peripheral blood immune cells.

135 this was accompanied by profound structural perturbations in the aging SC niche.

136 onse to emotion and cognitive stress induces perturbations in the heart and the peripheral vasculatur

137 intracellular complement, demonstrates that perturbations in the LFA-1-C3-axis contribute to primary

138 Targeted perturbations in the NPC structure revealed a dynamic re

139 these phenotypes were associated with subtle perturbations in the photorespiratory cycle of HPR1-T335

140 oncept that periodontitis is associated with perturbations in the resident microbiome.

141 Moreover, perturbations in these mechanisms can be involved in dis

142 ance of S-acylation, it is unsurprising that perturbations in this process, including mutations in ZD

143 Selected chemical and genetic perturbations in this screening platform, including rapa

144 Here, we tested perturbations in tropomyosin structure, biochemistry, an

145 y modulate force and work output to minimize perturbations in uneven terrain.

146 lent equine SOD1 variant would share similar perturbations in vitro, thereby explain horses' suscepti

147 e is also highly vulnerable to many types of perturbation, including heat, force, osmotic pressure, l

148 a variety of ways to adapt to environmental perturbations, including regulation of gene expression.

149 s with HIE display significant physiological perturbations, including spontaneous hypothermia.

150 e, cell type, local environment and external perturbations influence them.

151 develop PCS inference procedures, namely PCS perturbation intervals and PCS hypothesis testing, to in

152 llutant transformation is complicated by the perturbations introduced to the subsurface by ISCR.

153 namics occurring in the cell after a genetic perturbation is applied, confirming the importance of in

154 Importantly, the phenylpropanoid perturbation is not alleviated in gir1 ref8 and myb4 ref

155 Moreover, the pattern of long-range perturbations is similar to that detected previously in

156 ance in response to dynamic cytosolic Ca(2+) perturbations is unknown.

157 P/E formation, where sub-angstrom structural perturbations lead to an order-of-magnitude change in ki

158 gency in the stepwise acquisition of genetic perturbations leading to increasing antibiotic resistanc

159 This perturbation leads to destabilization of the domain-doma

160 Optogenetic perturbations, live imaging, and time-resolved ChIP-seq

161 ity observed in disorders linked to dopamine perturbations may be attributable to specific D1R and D2

162 Circumstantial evidence suggests that these perturbations may be due to altered epigenetic profiles

163 These perturbations may cause major reshuffling of Arctic spec

164 Here, we employed the molecular degree of perturbation (MDP) score adapted to plasma biomarkers in

165 to mechanical, genetic, and pharmacological perturbations, mimicking a range of physiological and pa

166 op perturbation phase, a loop-specific local perturbation model is designed to improve the accuracy o

167 protein complexes involved in adaptation to perturbation, most notably, stress granule (SG) proteins

168 These perturbations occurred independent of the locomotor rhyt

169 ion (ETE), and associated major carbon cycle perturbations occurred synchronously around the Triassic

170 Perturbation of addition of second heart field (SHF) car

171 rnalized in food vacuoles contributed to the perturbation of amino acid metabolism, TCA cycle and oxi

172 an result from chromosomal rearrangements or perturbation of architectural factors.

173 localize the negative charge was probed as a perturbation of aromaticity using NICS scans.

174 utations affect IP(3)R function, and how the perturbation of as-sociated calcium signals contribute t

175 The lattice interference and perturbation of atomic periodicity at the perovskite sur

176 Perturbation of BACE1 post-Golgi trafficking results in

177 further resolve oxidation-driven structural perturbation of CaM, with implications for RyR regulatio

178 Therefore, we questioned whether perturbation of CBS/H(2) S activity could drive mitochon

179 ting revealed that impaired growth is due to perturbation of cell cycle progression rather than induc

180 Genetic or pharmacological perturbation of cellular machinery involved in the bioge

181 o changes in membrane composition induced by perturbation of endogenous lipid biosynthetic pathways o

182 depleted prior to protrusion onset and that perturbation of ezrin's affinity for actin modulates pro

183 Perturbation of gene expression, acquisition of microsco

184 Finally, we show that perturbation of Golgi homeostasis induces cell death of

185 Perturbation of host DNA methylation is a mechanism indu

186 The results reveal how perturbation of IFN-alpha/beta signaling in neurons can

187 We propose that functional perturbation of male microglia is an important cause for

188 esses, we perform live imaging and molecular perturbation of migrating chick neural crest cells in vi

189 ncreased glycolysis was likely a response to perturbation of mitochondrial function, as reflected in

190 Perturbation of MT-nanotube formation and Tkv internaliz

191 Moreover, perturbation of OSN function via knockout of the odorant

192 Molecular perturbation of PAK4 in multiple RMS models in vitro and

193 Controlled perturbation of protein activity is essential to study p

194 d their characterization, strategies for the perturbation of proteins, and methodologies for time-res

195 ic excision of this localisation element and perturbation of RAB13 mRNA targeting-but not translation

196 Interestingly, no substantial perturbation of replication fork progression was observe

197 ingle-cell profiling demonstrated no adverse perturbation of retinal pigment epithelium (RPE) transcr

198 Furthermore, local perturbation of stomatal development has little influenc

199 tion in the mouse liver and demonstrate that perturbation of the 12-hour clock, but not the core circ

200 Defects in CSA or CSB result in perturbation of the abscission leading to the formation

201 n visual motion is paired with an unexpected perturbation of the body.

202 abditis elegans, low vitamin B12, or genetic perturbation of the canonical propionate breakdown pathw

203 In male and female mice, acute perturbation of the cerebellar vermis (lobule 4/5) or si

204 Strikingly, however, perturbation of the Fibronectin matrix rescues the neura

205 Antibiotic-induced perturbation of the human gut flora is expected to play

206 ellar surface recordings showed a functional perturbation of the lateral reticular nucleus-cerebellum

207 These results suggest a resilience to perturbation of the microbiota's starting profile.

208 nalogues that stimulated T-cells displayed a perturbation of the natural peptides displayed by HLA-B*

209 arly when they cross time and length scales, perturbation of these loops by external changes can gene

210 CRISPRi perturbation of these super-enhancers by tethering trans

211 results provide molecular insights into how perturbation of translational homeostasis regulates cell

212 n post-nuclear degradation lens fiber cells, perturbation of which causes early-onset cataracts.

213 owth by live imaging of early embryogenesis, perturbations of blastomere dimensions, and reconstituti

214 We prove that light driven perturbations of cell membrane potential induce homeosta

215 ar reactivity can be boosted by light driven perturbations of cellular homeostasis and that this bios

216 ds, the improved systems display more robust perturbations of enhancer activity and gene transcriptio

217 howed an early stress response that includes perturbations of metabolic, mechanical, and proteostasis

218 Perturbations of microtubules and motor proteins disrupt

219 n Ran and importin beta signaling induced by perturbations of Ran in mouse oocytes while examining th

220 xpression analyses following 14 experimental perturbations of relevance to the striatum, we discovere

221 ed for many years, it is now recognised that perturbations of the autophagy pathway itself can also l

222 Perturbations of the daily cycle have been linked to ele

223 ep is demonstrated to be invariant to energy perturbations of the intermediate states.

224 ch interactomes will enable the study of how perturbations of these interactions affect disease.

225 Perturbations of transcription or R-loop resolution are

226 used to investigate the influence of climate perturbation on potentially dangerous natural phenomena.

227 fects of genetic, chemical and environmental perturbations on biological systems, as well as searchin

228 ubunits forming the homodimer and allosteric perturbations on cGMP binding.

229 We show that perturbations on the sides of cells (or dendrites) facil

230 uction of dynamic pilus activity by chemical perturbation or by a mutation in the outer-membrane pilu

231 e expression data acquired following genetic perturbation or environmental stimulus.

232 ere were unique differences in the biomarker perturbation patterns and the overall degree of inflamma

233 In the loop perturbation phase, a loop-specific local perturbation m

234 We aimed at defining possible microbial perturbations preceding early atopic sensitization.

235 We design a simulated perturbation process to characterize the contribution of

236 obial communities that experience antibiotic perturbation represent a key system with important medic

237 ell types are affected across this cohort of perturbations, representing key cellular effects across

238 t also enables comparison of binding data to perturbation-response data that have been processed by n

239 tting significance thresholds on binding and perturbation-response data, and show that it improves co

240 a large-scale and comprehensive catalogue of perturbation-response signatures by utilizing a diverse

241 ultiplexed transcriptional profiling of post-perturbation responses across a mixture of samples with

242 integrated set of responses to environmental perturbations resulting in either cellular death or the

243 Genetic perturbations revealed that the neurogenic/apoptotic fat

244 Adamts19 knockout mice precedes hemodynamic perturbation, showing that a tight balance in the Wnt-Ad

245 ed immediately by demographic and ecological perturbations, similar to the empirically derived treatm

246 omic data, which can reveal the tumor signal perturbation status and subtype classification.

247 evidence for sensory-based decisions, recent perturbation studies in rodents and non-human primates h

248 Further, in response to perturbations, subjects with an mTBI utilized hip strate

249 ional and interaction changes resulting from perturbations such as drug treatment and disease state.

250 The molecular changes induced by perturbations such as drugs and ligands are highly infor

251 antly, we also found that pathophysiological perturbations such as elevated ADP concentration weakens

252 nvironmental stochasticity and deterministic perturbations, such as recruitment, fecundity of experie

253 in vivo k (cat)s are robust against genetic perturbations, suggesting that metabolic adaptation to g

254 to deal more effectively with environmental perturbation than their low-shore counterparts.

255 We demonstrated by genetic perturbation that cellular nucleic acid-binding protein

256 Chemical and genetic perturbations that alter oxygen consumption or redox sta

257 that redox shifts can also arise from small perturbations that are amplified by nonlinear positive f

258 Indeed, there are no genetic perturbations that are known to both improve long-term s

259 d artificial fliers must contend with aerial perturbations that are ubiquitous in the outdoor environ

260 What distinguishes inconsequential perturbations that barely alter circuit behavior from di

261 nor hearts to substantial pathophysiological perturbations that can influence heart transplant succes

262 vulnerability of heme metabolism to genetic perturbations that can lead to increased survival in the

263 ecies, aberrant cellular metabolism or other perturbations that cause DNA damage.

264 arely alter circuit behavior from disruptive perturbations that drastically disturb circuit output re

265 work for identifying combinatorial signaling perturbations that drive cells toward specific fates, in

266 Acute genetic perturbations that eliminated caveolae in aECs, but not

267 Our approach depends on order perturbations that indicate interactions.

268 They also introduce mechanical perturbations that interfere with measurements of the be

269 This paradigm induces robust perturbations that permeate frontotemporal networks, inc

270 mutations result in similar nuclear envelope perturbations that were reversed in the isogenic mutatio

271 cellular systems are subjected to extensive perturbations, the statistical relationships between pho

272 Variants of the orbital-optimized perturbation theory (NEO-OOMP2) method achieve nearly th

273 l modes, which agree with density functional perturbation theory calculations.

274 es probes revealing distinct phenotypes upon perturbation, thereby informing on the function and mech

275 mpacts, is expected to cause global climatic perturbations through injections of soot into the upper

276 ehavioral manifold that is preserved under a perturbation to cell speeds, and seen in Mouse T cells a

277 With minimal perturbation to cells, ECORE allows long-term optical re

278 By applying external perturbation to these control nodes, it is theorized tha

279 ntly, these interactions are not affected by perturbations to crucial components of the canonical mac

280 ally rapid plate motions, and uniquely large perturbations to global biogeochemical cycles.

281 TMS was used to induce controlled perturbations to individually defined nodes of the defau

282 ex genetic diseases require multiplexed gene perturbations to interrogate combinations of genes and r

283 Elevated nutrient loading and perturbations to major ion composition have resulted fro

284 nd dynamic group of diseases that arise from perturbations to multiple biological networks within the

285 hese metabolic disorders are associated with perturbations to nitric oxide (NO) signaling and impaire

286 Perturbations to OM lipid asymmetry sensitize the cell t

287 ds by mapping (1)H-(15)N HSQC chemical shift perturbations to our new NMR structure.

288 of visual cortical circuits to recover from perturbations to sensory drive.

289 l/NF-kappaB signaling module with respect to perturbations to the dosage of maternally-expressed dors

290 Perturbations to viscoadaptation affect solubility and p

291 ls typically respond to chemical or physical perturbations via complex signaling cascades which can s

292 echniques into six complementary approaches: perturbation, visualization, substitution, characterizat

293 single osteoblast under external mechanical perturbations, was utilised to simulate and examine modu

294 ocalization analysis and CRISPR-Cas9 genetic perturbation, we find that although DAPs and sDAPs are p

295 target sequences under controlled mechanical perturbations, we characterize position-dependent effect

296 genomic analysis, microscopy, and molecular perturbations, we show that Naegleria encodes conserved

297 These perturbations were accompanied by reduced expression of

298 s the latent growth behavior and response to perturbation, while simultaneously correcting for random

299 m (RPE) and outer retinal atrophy (e.g., RPE perturbation with associated hypotransmission or hypertr

300 esults in significant increases in molecular perturbation, with the highest values being detected in