ライフサイエンスコーパス: phaeochromocytoma

1 ogically proven medullary thyroid cancer and phaeochromocytoma.

2 re included in our database, 563 of whom had phaeochromocytoma.

3 gioblastomas, renal cell carcinoma (RCC) and phaeochromocytoma.

4 an important cause of familial and isolated phaeochromocytoma.

5 ve amine intolerance, carcinoid syndrome and phaeochromocytoma.

6 crest tumours such as neuroblastoma (NB) and phaeochromocytoma.

7 ed in one of the two patients with bilateral phaeochromocytoma.

8 ied in three of eight kindreds with familial phaeochromocytoma.

9 haemangioblastomas, renal cell carcinoma and phaeochromocytoma.

10 with aldestosterone adenomas and seven with phaeochromocytoma.

11 been found in approximately 10% of sporadic phaeochromocytomas.

12 genes for involvement in the pathogenesis of phaeochromocytomas.

13 only a minor role for GDNF in the genesis of phaeochromocytomas.

14 o contribute to the pathogenesis of sporadic phaeochromocytomas.

15 as, 12 MEN 2 phaeochromocytomas and five VHL phaeochromocytomas.

16 nce of somatic change in GDNF in 28 sporadic phaeochromocytomas, 12 MEN 2 phaeochromocytomas and five

17 in the pathogenesis of familial or sporadic phaeochromocytomas, allelic variation at the GDNF locus

18 In addition, familial phaeochromocytoma alone has also been reported and we an

19 mangioblastomas, renal cell carcinoma (RCC), phaeochromocytoma and other tumours.

20 ransformed knowledge of the genetic basis of phaeochromocytoma and paraganglioma (PPGL).

21 Rarely, phaeochromocytomas and adrenal malignant masses can pres

22 in 28 sporadic phaeochromocytomas, 12 MEN 2 phaeochromocytomas and five VHL phaeochromocytomas.

23 hylation was found in 22% (5/23) of sporadic phaeochromocytomas and in 55% (37/67) of neuroblastomas

24 Metastatic phaeochromocytomas and paragangliomas (MPPGs) are orphan

25 Phaeochromocytomas and paragangliomas (PPGL) are rare ne

26 locally aggressive, recurrent or metastatic phaeochromocytomas and paragangliomas (PPGLs).

27 haracterised by medullary thyroid carcinoma, phaeochromocytoma, and extra-endocrine features.

28 hyroid carcinoma, incidence and treatment of phaeochromocytoma, and the penetrance of extra-endocrine

29 roup B, two patients with isolated bilateral phaeochromocytoma; and Group C, six cases of multiple ex

30 Phaeochromocytomas are neoplasias of neural crest origin

31 y characterise the outcomes of management of phaeochromocytoma associated with multiple endocrine neo

32 factors have been implicated in up to 10% of phaeochromocytoma cases, but recent data suggest that ge

33 Experiments were performed on rat phaeochromocytoma cells exposed to 21% O(2) (normoxia) o

34 its GEF activities on the morphology of PC12 phaeochromocytoma cells.

35 multiple endocrine neoplasia type 2-related phaeochromocytoma continues to rely on adrenalectomies w

36 nherited cases accounted for only 10% of all phaeochromocytoma diagnosis, current estimates are at le

37 ns were identified in patients with familial phaeochromocytoma disease, but a c277C-->T (R93W) sequen

38 SGs in neural crest tumours, we (a) analysed phaeochromocytomas for 3p allele loss (n=41) and RASSF1A

39 r NF1: Group A, eight kindreds with familial phaeochromocytoma; Group B, two patients with isolated b

40 ne mutations in GDNF in 16 cases of familial phaeochromocytoma (groups A, B and C) and looked for evi

41 by which SDH subunit mutations predispose to phaeochromocytomas has not been defined in detail, but d

42 as mutations in SDH cause paragangliomas and phaeochromocytomas (HPGL).

43 patients'RET genotype, type of treatment for phaeochromocytoma (ie, unilateral or bilateral operation

44 ed with multiple endocrine neoplasia type 2, phaeochromocytoma, is not as well characterised in terms

45 Inherited predisposition to phaeochromocytoma (MIM No 171300) occurs in multiple end

46 Extra-adrenal phaeochromocytomas occur and may be referred to as parag

47 Group C, six cases of multiple extra-adrenal phaeochromocytoma or adrenal phaeochromocytoma with a fa

48 roup of patients with multiple extra-adrenal phaeochromocytoma or adrenal phaeochromocytoma with a fa

49 proximately 20% of patients diagnosed with a phaeochromocytoma or paraganglioma carry a germline muta

50 oplasia type 2 (MEN 2), the newly delineated phaeochromocytoma-paraganglioma syndrome and, less commo

51 f function predisposes to the development of phaeochromocytoma/paraganglioma (PPGL), wild type gastro

52 ite development and up-regulation of trkA in phaeochromocytoma (PC(12)) cells in vitro confirmed NGF-

53 of lead on the nicotinic AChR in rat clonal phaeochromocytoma PC12 cells using whole-cell and single

54 The rat phaeochromocytoma PC12 clonal cell line expresses an O2-

55 detect exocytosis of catecholamines from rat phaeochromocytoma (PC12) cells in response to a reductio

56 ometric recordings were made from individual phaeochromocytoma (PC12) cells using carbon fibre microe

57 ing the cellular responses to hypoxia in rat phaeochromocytoma (PC12) cells, an oxygen-sensitive clon

58 ia also evoked secretion from chemoreceptive phaeochromocytoma (PC12) cells, which was wholly Ca2+ de

59 free Ca2+ ([Ca2+]i) in oxygen-sensitive rat phaeochromocytoma (PC12) cells.

60 identify the O2-sensitive K+ channel in rat phaeochromocytoma (PC12) cells.

61 sterases on the nicotinic AChR in rat clonal phaeochromocytoma (PC12) cells.

62 HABs) and renal cell carcinoma (RCC) but not phaeochromocytoma (PHE) occur in type 1 VHL disease.

63 To further investigate the genetics of phaeochromocytoma predisposition, we analysed three grou

64 Phaeochromocytoma recurrence occurred in four (3%) of 15

65 ve been linked to the development of RCC and phaeochromocytoma, respectively, the precise basis for g

66 46% of phaeochromocytomas showed 3p allele loss (38.5% at 3p21.

67 The most frequent causes of phaeochromocytoma susceptibility are von Hippel-Lindau d

68 , germline SDHD and SDHB mutations may cause phaeochromocytoma susceptibility with or without associa

69 lelic variation at the GDNF locus may modify phaeochromocytoma susceptibility.

70 F is a good candidate gene to play a role in phaeochromocytoma susceptibility.

71 ay predispose to haemangioblastomas, RCC and phaeochromocytoma to a varying extent.

72 Phaeochromocytomas usually occur sporadically but may al

73 Bilateral phaeochromocytoma was diagnosed in 156 (50%) of 313 pati

74 To investigate the role of GDNF in sporadic phaeochromocytomas, we scanned a panel of 22 tumors.

75 (such as systemic arterial hypertension and phaeochromocytoma), which variously lead to increased ao

76 ever, 47 (57%) of 82 patients with bilateral phaeochromocytoma who underwent adrenal-sparing surgery

77 in 292 (86%) of 339 patients with bilateral phaeochromocytoma who underwent surgery.

78 e extra-adrenal phaeochromocytoma or adrenal phaeochromocytoma with a family history of neuroectoderm

79 e extra-adrenal phaeochromocytoma or adrenal phaeochromocytoma with a family history of neuroectoderm