コーパス検索結果 (１語後でソート)
通し番号をクリックするとPubMedの該当ページを表示します
1 oteins of these cells, and to the neutrophil phagolysosome.
2 ents that assemble in the plasma membrane or phagolysosome.
3 by inhibiting phagosome maturation into the phagolysosome.
4 ighly adapted for life within the eukaryotic phagolysosome.
5 cquire EEA1 and subsequently mature into the phagolysosome.
6 me, preventing progression to a bactericidal phagolysosome.
7 as been suggested to occur in the macrophage phagolysosome.
8 ferating within the harsh environment of the phagolysosome.
9 but rather resides and survives in an acidic phagolysosome.
10 ects of the acidic environment in the mature phagolysosome.
11 ants to survive the harsh environment of the phagolysosome.
12 activity was a function of alkalinizing the phagolysosome.
13 at effects were mediated by alkalinizing the phagolysosome.
14 , which by all criteria resides in a typical phagolysosome.
15 that a Cl2-like oxidant is generated in the phagolysosome.
16 ary tract and the acidic mammalian host cell phagolysosome.
17 and subsequent pathogen clearance within the phagolysosome.
18 leased in the proteolytic environment of the phagolysosome.
19 llows for innate immune detection within the phagolysosome.
20 the parasite is exposed to in the macrophage phagolysosome.
21 the bacteria are completely degraded within phagolysosomes.
22 harboring live mycobacteria to progress into phagolysosomes.
23 agents to kill phagocytosed pathogens within phagolysosomes.
24 ese parasites to replicate within macrophage phagolysosomes.
25 the GlcNAc response in signaling entry into phagolysosomes.
26 internalized by macrophages and processed in phagolysosomes.
27 d mycobacteria, which normally progress into phagolysosomes.
28 ent of infection by Leishmania in macrophage phagolysosomes.
29 ication, such as would occur within maturing phagolysosomes.
30 r C. koseri organisms are colocalized within phagolysosomes.
31 se with early endosomes but do not mature to phagolysosomes.
32 tion of nascent phagosomes into microbicidal phagolysosomes.
33 xime-sensitive pathway and replicated within phagolysosomes.
34 llenge, in more dense fractions representing phagolysosomes.
35 and replication within mammalian macrophage phagolysosomes.
36 tter two reactions probably occur within RPE phagolysosomes.
37 e that is capable of parasitizing macrophage phagolysosomes.
38 taining the agent of HGE fail to mature into phagolysosomes.
39 tments, such as the gastric lumen, or within phagolysosomes.
40 s that maintains Mtb in spacious proteolytic phagolysosomes.
41 ects them from degradation inside macrophage phagolysosomes.
42 tory cells with unusual striated deposits in phagolysosomes.
43 , pathogens are internalized and degraded in phagolysosomes.
44 rs are required to disrupt the biogenesis of phagolysosomes.
45 by engulfing and digesting pathogens within phagolysosomes.
46 e molecules sequestered and destroyed within phagolysosomes.
47 s actively phagocytose bacteria then acidify phagolysosomes.
48 n with CD36 and in bacterial escape from the phagolysosomes.
49 ptides and degradative enzymes within acidic phagolysosomes.
50 pid traffic are delivered and made active in phagolysosomes.
51 including ROS-mediated microbial killing in phagolysosomes.
52 stantial proportion of infecting bacteria to phagolysosomes.
53 which subsequently mature into microbicidal phagolysosomes.
54 peared to be trapped in cathepsin D-positive phagolysosomes.
55 ong the Muller phagosomes, >90% matured into phagolysosomes.
56 induction and CO increased acidification of phagolysosomes.
57 rocess of phagosomes maturing into acidified phagolysosomes.
58 stage, but do not mature to fully acidified phagolysosomes.
59 ion and processing of bacteria in hydrolytic phagolysosomes.
60 to greater amyloid content within microglial phagolysosomes.
61 in macrophage phagosomes as they mature into phagolysosomes.
63 e CFTR chloride channel was also detected in phagolysosomes, a special organelle formed after phagocy
64 ive to other conditions, in part by delaying phagolysosome acidification without affecting production
65 osomal acidification and that in its absence phagolysosomes acidify poorly, thus providing an environ
67 omes then fuse with lysosomes to mature into phagolysosomes, acquiring an acidic and hydrolytic lumen
68 stores of MMP12 are mobilized to macrophage phagolysosomes after the ingestion of bacterial pathogen
69 progression of the nascent phagosome into a phagolysosome, allowing for replication in a compartment
70 ranules with their primary site of action in phagolysosomes, although some peptide is released into t
71 lular bacterium that resides in an acidified phagolysosome and has a remarkable ability to persist in
74 oorganism are its ability to thrive within a phagolysosome and its ability to persist in the environm
75 ORP1L formed discrete tethers between the phagolysosome and the endoplasmic reticulum, resulting i
77 mycobacteria delivered to phagosomes versus phagolysosomes and discovered that bacteria survive and
78 ses that captured antigens exit from damaged phagolysosomes and enter the cytosol, where they are pro
81 erative fusion-fission events between mature phagolysosomes and the plasma membrane, a process we ter
84 Live S. cerevisiae cells isolated from the phagolysosome are induced for genes of the glyoxylate cy
88 IgG beads matured significantly faster into phagolysosomes as judged by colocalization with lysosoma
89 ciated with the maturation of the LCP into a phagolysosome, as documented by the acquisition of LAMP-
90 hagolysosome fusion, although recruitment of phagolysosome-associated proteins lysosome-associated pr
91 rcinogenesis, biofilm formation, escape from phagolysosomes, bacteriocin production, toxin activity a
92 d intermediate levels of interaction, and PS phagolysosomes became isolated within the cytoplasm.
94 s PA, into phagocytes to improve and recover phagolysosome biogenesis and pathogen killing while limi
96 n of a type III secretion system that blocks phagolysosome biogenesis represents a novel mechanism by
97 ration independently of Rab7 and coordinates phagolysosome biogenesis through size-selective transfer
104 ection of reactive oxygen species within the phagolysosome but largely failed to eliminate the metacy
105 ophage results in the formation of an acidic phagolysosome but the host cell has no information on th
106 or its adaption to the acidic environment in phagolysosomes but is not required for the suppression o
107 hloroquine accumulates inside the macrophage phagolysosome by ion trapping where it exerts potent ant
110 that point, however, the characteristics of phagolysosomes changed in several ways that indicated di
112 ere fully fusiogenic and matured to spacious phagolysosomes containing degraded bacteria, whereas som
113 ed by NADPH oxidase 2 (NOX2) was detected in phagolysosomes containing either silica particles or non
115 (iii) promote Ca(2+)-dependent maturation of phagolysosomes containing Mycobacterium tuberculosis (MT
116 to survive in the acidic environment of the phagolysosome, contributes to the pathogen's resilience
119 ded or not; and iii) nanoparticle-containing phagolysosomes did not fuse with non-matured mycobacteri
120 r, viable mycobacteria have been observed in phagolysosomes during infection of cultured macrophages,
124 s, whereas the migR mutant resided in mature phagolysosomes enriched with both lamp-1 and cathepsin D
126 une responses, but little is known about how phagolysosomes finally resolve their phagocytic cargo of
128 mbiae that provide new mechanistic detail of phagolysosome formation and clodronate liposome processi
129 ives inside macrophages by perturbing normal phagolysosome formation and that USA300 may sense phagos
130 tor interaction that guides the phagosome to phagolysosome formation belies the complexity of combina
132 ernalization, wild-type FcgammaRIIA-mediated phagolysosome formation was observed as indicated by col
137 ownstream' degradative pathways, leading to 'phagolysosome' formation and intracellular killing of in
140 ogenes and presented by H2-M3, also requires phagolysosome fusion and cleavage by the proteasome.
141 hrough mechanisms that included promotion of phagolysosome fusion and induction of nitric oxide.
142 rived from by LLO- L. monocytogenes requires phagolysosome fusion and processing by the proteasome.
144 jor antimicrobial mechanisms of macrophages: phagolysosome fusion and the production of toxic reactiv
146 Thus, the tail of FcgammaRIIA contributes to phagolysosome fusion by a mechanism that does not requir
147 a specialized compartment that evades normal phagolysosome fusion called the Legionella-containing va
149 Fcgamma receptor-dependent phagocytosis and phagolysosome fusion in the presence and absence of the
150 II was required for a form of Ca2+-dependent phagolysosome fusion that is analogous to Ca2+-regulated
151 hat: (i) calcium signaling is a late step in phagolysosome fusion, (ii) a line of communication exist
152 ern-deficient mutants were unable to support phagolysosome fusion, although recruitment of phagolysos
153 FcR-dependent and -independent phagocytosis, phagolysosome fusion, cytokine production, NLRP3 inflamm
157 , explorations of the oxidation chemistry of phagolysosomes have been hampered by the organelle's ina
158 acterial phagocytosis and destruction within phagolysosomes, host cell apoptosis, and autophagy.
169 lt pathway of phagosomal maturation into the phagolysosome includes temporally organized cyclical wav
170 anisms have been reported to escape from the phagolysosome into the cytosol, we hypothesized that thi
173 m to prevent acidification of the macrophage phagolysosome is thought to be critical for intracellula
174 demonstrate that B. burgdorferi confined to phagolysosomes is a potent inducer of cytosolic signals
175 parasite cells to survive inside macrophage phagolysosomes is associated with 20- to 50-fold reducti
177 e dispensable for initial PV maturation to a phagolysosome-like compartment but are involved in vacuo
178 ype IV secretion system (T4SS) to generate a phagolysosome-like parasitophorous vacuole (PV) in which
179 plicates in alveolar macrophages in a unique phagolysosome-like parasitophorous vacuole (PV) required
180 en Coxiella burnetii directs biogenesis of a phagolysosome-like parasitophorous vacuole (PV), in whic
184 the presence of a Na(+) gradient between the phagolysosome lumen and the cytosol were critical for th
185 D-Mtb but not R-Mtb colocalizes with mature phagolysosome marker LAMP-1 and with vacuolar proton ATP
187 Phagosomal compaction, a crucial step in phagolysosome maturation, is driven by contact of Rab5a-
189 ol of CD1 molecules remains available on the phagolysosome membrane that is able to acquire lipid ant
190 ion suggests that MPEG1 remains bound to the phagolysosome membrane while simultaneously forming pore
192 he intensity of LAMP-1 immunofluorescence in phagolysosome membranes in calcium-buffered vs. control
194 partmentalization of Shigella species to the phagolysosome might be a protective response of the host
196 tions are thought to exist within macrophage phagolysosomes, no direct evidence for lipid A modificat
197 can grow only in acidic niches, such as the phagolysosome of AMs, and not in neutral or alkaline env
199 Our observations support the view that the phagolysosome of human neutrophils uses the myeloperoxid
200 e this environment is similar to that in the phagolysosome of J774.16 macrophage-like cells, our find
201 unction associated with lipid storage in the phagolysosome of macrophages in a manner that mimicked l
202 st intracellular environment, such as in the phagolysosome of macrophages, which is characteristicall
204 hages, wild-type Shigella was trapped in the phagolysosome of PMN as visualized by electron microscop
205 its several strategies to survive within the phagolysosome of vertebrate macrophages and be transmitt
206 , which are encountered by the fungus in the phagolysosomes of activated macrophages, through a Pma1-
210 of partially-digested, soluble material from phagolysosomes of macrophages through transient, iterati
212 rement of the free chloride level within the phagolysosomes of neutrophils and other phagocytic cell
213 ion of unprocessed outer segments within the phagolysosomes of RPE cells and the presence of inflamma
215 ffect of chloroquine, which raises the pH of phagolysosomes, on the anticryptococcal activity of mono
218 es of Chlamydia to inhibit the biogenesis of phagolysosomes permits their survival and replication wi
221 IFN-gamma, failed to trigger expression and phagolysosome recruitment of TCIRG1, as well as to promo
224 their contents quickly, poly-e-caprolactone phagolysosomes showed intermediate levels of interaction
225 in the acidic environments of phagosomes and phagolysosomes suggests its initial metabolic adjustment
227 degradation of the vaccine strain within the phagolysosome, target antigens are released into the cyt
231 out the chemical reactions that occur in the phagolysosome, the cellular compartment that kills patho
232 model phagosomes, which normally mature into phagolysosomes, the existence of cyclical waves of phosp
234 in this is Nramp1, which effluxes iron from phagolysosomes thereby depriving the engulfed pathogens
236 termined that by stochastically acidifying a phagolysosome to a pH within the observed distribution,
239 sosomal protease cathepsin L decreased in PS phagolysosomes to 23% by 4 h after phagocytosis, indicat
240 n, the neutrophil NADPH oxidase assembles on phagolysosomes to catalyze the transfer of electrons fro
241 on of transition metal concentrations within phagolysosomes to eliminate internalized pathogens.
243 and Pol peptides utilized biological cues of phagolysosomes to realize phagolysosomal escape and epit
245 lly acquire antigen and rapidly traffic from phagolysosomes to the plasma membrane as part of DC matu
246 in C. elegans, we previously discovered that phagolysosomes tubulate into small vesicles to facilitat
247 lowing degradation of their contents, mature phagolysosomes undergo resolution, a process that remain
248 al macrophages (HLA-DR+, CD11c+ CD11b+ CD1c- phagolysosome+) upon dermal fibroblast proliferation.
249 osphate-positive phagosomes that mature into phagolysosomes using a pathway similar to that of profes
251 identified the molecular pathway regulating phagolysosome vesiculation that promotes efficient resol
252 (PtdIns(4)P), which is abundant in maturing phagolysosomes, was depleted as they tubulated and resor
253 lar internalization of pathogens into acidic phagolysosomes, we herein report "turn-on" fluorescence
256 kedly reduced rate of protein degradation in phagolysosomes, when compared to rates measured for prot
258 ining phagosomes were rapidly processed into phagolysosomes, whether MA had been included or not; and
259 Phagosomes fuse with lysosomes to generate phagolysosomes, which play a key role in enzymatic diges
260 capsulatum, survives and proliferates within phagolysosomes, while the mycelial phase exists only as
262 tivity inside Leishmania-infected macrophage phagolysosomes with targeted delivery of an inhibitor of