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1 tion, or as medical problems to be addressed pharmaceutically.
2 dependent cell death, which can be triggered pharmaceutically.
4 active pharmaceutical ingredient (API) and a pharmaceutically acceptable coformer to systematically t
5 as a therapeutic agent is the development of pharmaceutically acceptable delivery forms for various i
9 cation of this protocol for the synthesis of pharmaceutically active butenafine analogues is shown.
11 work has facilitated expedient syntheses of pharmaceutically active compounds currently in clinical
12 Preliminary screening of a library of 1280 pharmaceutically active compounds identified inhibitors
14 Many commercial drugs, as well as upcoming pharmaceutically active compounds in the pipeline, displ
15 ass of synthetic precursors for a variety of pharmaceutically active compounds, as well as for nitril
17 though aromatic rings are common elements in pharmaceutically active compounds, the presence of these
18 o the carbon isotope substitution of several pharmaceutically active compounds, whereby complete carb
25 molecules, (v) cyclisation and annulation to pharmaceutically active molecules, and (vi) coupling of
26 tance derives from the observation that many pharmaceutically active natural products contain a chlor
29 odology enables the synthesis of an array of pharmaceutically and agrochemically relevant halogen/sul
30 ed ring, allowing rapid access to a range of pharmaceutically and agrochemically relevant polycyclic
32 timodular enzymes that biosynthesize diverse pharmaceutically and ecologically important polyketides.
33 es have been made in red biotechnology using pharmaceutically and medically relevant applications, gr
34 ction provides a straightforward approach to pharmaceutically and synthetically useful 2-aminobenzoxa
35 ised using a simple dip-coating process from pharmaceutically approved materials using a gelatin drug
36 ds induce melanogenesis is of great interest pharmaceutically (as therapy for pigmentary diseases) an
37 Optimized HS interactions can be targeted pharmaceutically, as an HS mimetic significantly suppres
38 catalyst, thus allowing for the synthesis of pharmaceutically attractive alpha-diarylesters through a
40 that myofibrillar CK energy delivery can be pharmaceutically augmented in the failing human heart.
44 safe and efficacious delivery vehicles with pharmaceutically developable properties remains a major
46 r efforts to identify potent, selective, and pharmaceutically favorable next-generation M(5) antagoni
51 een developed to streamline the synthesis of pharmaceutically important 3,6-diarylated 1,2,4-triazolo
52 lowing efficient access to a wide variety of pharmaceutically important 3-arylquinoxalin-2-(1H)-ones.
54 a single target is sufficient to elicit the pharmaceutically important antioxidant response element
55 spp. plants have the capacity to synthesize pharmaceutically important APGs using dual functional CH
56 are a class of natural products that include pharmaceutically important aromatic compounds such as th
58 h-catalyzed direct arylation of a variety of pharmaceutically important azoles with aryl bromides is
59 the doors to studies on their widespread and pharmaceutically important bacterial signaling mechanism
60 provides a straightforward synthesis of the pharmaceutically important benzo[c]quinolizinium cation
62 iosynthetic pathways, including a variety of pharmaceutically important beta-hydroxylated antibiotics
64 nd sustainable approach for the synthesis of pharmaceutically important carbamoylated coumarins has b
66 re commonly used in the biosynthesis of many pharmaceutically important compounds and industrially us
67 o[1,2-a]indoles are known as medicinally and pharmaceutically important compounds, but there is a lac
68 scribed for sustainable synthesis of diverse pharmaceutically important dihydroquinolinone scaffolds
69 d for the synthesis of (R)-phenylalanine and pharmaceutically important drug intermediate (R)-3-pheny
71 represents a viable synthetic route towards pharmaceutically important fragments and further demonst
72 e the recent solution of X-ray structures of pharmaceutically important G protein-coupled receptors (
73 achieve efficacy-driven selectivity for many pharmaceutically important G-protein-coupled receptors.
74 ed for sustainable synthesis of a variety of pharmaceutically important gamma-ketoamides and 2-Azaspi
78 ies elucidate the lifestyle of a unique, and pharmaceutically important microorganism and highlight t
84 ding a versatile method for the synthesis of pharmaceutically important N-(hetero)arylated heteroaren
86 gs and is representative of a broad class of pharmaceutically important natural products with five-me
88 A novel, efficient route to biologically and pharmaceutically important o-(dimethylamino)aryl ketones
90 s developed to synthesize a diverse range of pharmaceutically important penta-substituted pyrroles.
91 col in a simple one-step high-yield route to pharmaceutically important polyarylated pyridopyrimidino
94 ed to investigate aggregate formation in the pharmaceutically important protein, recombinant human fa
99 mma-butyrolactones control the production of pharmaceutically important secondary metabolites by bind
100 synthetic transformations, the resolution of pharmaceutically important small molecules including pol
102 tive biosensor is effective in screening new pharmaceutically important substrates and mARC inhibitor
107 sed procedure for the efficient synthesis of pharmaceutically important triflones and bis(trifluorome
109 t operons in E. coli and the 'more complex', pharmaceutically important, Streptomyces coelicolor.
111 hod for the construction of biologically and pharmaceutically interesting functional structures.
112 method for the synthesis of a new series of pharmaceutically interesting functionalized 5-(2-arylimi
113 for the synthesis of a number of potentially pharmaceutically interesting new trifluoromethylated com
114 Microbial synthesis of nutraceutically and pharmaceutically interesting plant polyphenols represent
115 ient information about a molecule to predict pharmaceutically interesting properties directly from th
116 a wide range of potentially biologically and pharmaceutically interesting substituted indazoles in go
117 This allowed for the deuteration of complex pharmaceutically interesting substrates, including examp
119 These findings may provide new strategies to pharmaceutically modulate GPCR function, which might eve
122 monoclonal antibody natalizumab proved that pharmaceutically obstructing this process is an effectiv
123 of virulent lipids in mycobacteria and other pharmaceutically or ecologically important polyketides a
124 ir cytokine/Ig production in vitro, and that pharmaceutically or genetically blocking the interaction
125 rbonyl compounds to access a wide variety of pharmaceutically potential heteroaromatics, i.e., 4-(tri
130 s method serves as an efficient entry to the pharmaceutically relevant 1-arylcyclohexylamine scaffold
131 addition products were readily converted to pharmaceutically relevant 3,5-disubstituted pyrrolidinon
132 catalyzes the atroposelective bromination of pharmaceutically relevant 3-arylquinazolin-4(3H)-ones (q
134 cation in the biotechnological production of pharmaceutically relevant alkaloid scaffolds as well as
135 tility of this approach, 10 biologically and pharmaceutically relevant alkaloids were prepared using
136 provides access to synthetically useful and pharmaceutically relevant alpha-amino boronic acid deriv
137 also used for preparative-scale synthesis of pharmaceutically relevant amines and a key intermediate
138 omplexity and the expedient exploration of a pharmaceutically relevant and C(sp(3))-rich structural l
140 cess are likely to be of use in a variety of pharmaceutically relevant and wider synthetic applicatio
141 sive variety of coupling partners, including pharmaceutically relevant APIs, readily participate unde
142 power of this framework is demonstrated with pharmaceutically relevant applications in the context of
144 , secondary and tertiary alcohols as well as pharmaceutically relevant aryl and heteroaryl bromides a
145 ng reactions, exploring chemical space using pharmaceutically relevant aryl boronates for radiofluori
146 ation of amines and carboxylic acids to form pharmaceutically relevant azaheterocycles via organophos
147 rocycles to provide structurally diverse and pharmaceutically relevant azaspiro[2.y]alkanes in high y
148 as used as the key step for the synthesis of pharmaceutically relevant biaryl sulfur-containing compo
151 tion of copper-mediated radiofluorination of pharmaceutically relevant boronate ester substrates.
154 namides, and azoles, for the construction of pharmaceutically relevant C(sp(3))-N bonds under unified
156 luorescein (5-BMF) for the quantitation of a pharmaceutically relevant carboxyl-containing analyte in
157 )-C(sp(3)) cross-coupling provides access to pharmaceutically relevant chiral N-benzylic heterocycles
158 which facilitate the divergent synthesis of pharmaceutically relevant compound libraries from a sing
160 astereoselective late-stage modifications of pharmaceutically relevant compounds and selective twofol
162 be adapted to (13)C-isotope labeling of six pharmaceutically relevant compounds starting from Ba(13)
163 biquitous among living organisms and include pharmaceutically relevant compounds such as antibiotics
165 ines and -piperidines, an important class of pharmaceutically relevant compounds that contain a quate
166 ,2-transposition of phenolic oxygen in three pharmaceutically relevant compounds was successfully dem
167 e conditions are demonstrated on an array of pharmaceutically relevant compounds, and detailed mechan
168 This versatile method enables access to pharmaceutically relevant compounds, including intermedi
177 but show that its main inhibitory action at pharmaceutically relevant concentrations results from st
178 process is demonstrated in the synthesis of pharmaceutically relevant cores from simple styrene moti
179 g 48 cyclic and acyclic secondary amines (10 pharmaceutically relevant cores) and 34 terminal olefins
181 linic, high-resolution structural studies of pharmaceutically relevant derivatives have been limited
184 from a natural product (geraniol), alongside pharmaceutically relevant drug compounds (indomethacin,
185 for the site-selective thiolation of various pharmaceutically relevant electron-rich heteroarenes wit
186 formation provides the most direct access to pharmaceutically relevant enantioenriched gamma-nitroest
187 nisms of allosteric control of this class of pharmaceutically relevant enzymes, and provides a new pa
188 nstrate the synthetic utility of our method, pharmaceutically relevant examples of both product class
190 As one of the best studied members of the pharmaceutically relevant family of G-protein-coupled re
193 timization for the A2A adenosine receptor, a pharmaceutically relevant G protein-coupled receptor.
194 he contribution of the sugar constituents of pharmaceutically relevant glycosylated natural products,
195 pe for the transformation of substrates with pharmaceutically relevant heteroarenes render this metho
198 radiosynthesis of seven structurally complex pharmaceutically relevant heterocycle-containing molecul
201 -MS excipient screening data collected for a pharmaceutically relevant IgG4 mAb being characterized t
202 bling expansion of the chemical space around pharmaceutically relevant indole and indoline derivative
203 ical sp(2)-sp(3) cross-coupling methods to a pharmaceutically relevant intermediate and optimize each
205 sed across diverse chemical spaces, spanning pharmaceutically relevant literature compounds and more
207 based on mapping the separation landscape of pharmaceutically relevant mixtures across both first ((1
208 ly available nucleosides into NTPs featuring pharmaceutically relevant modifications using inexpensiv
210 sets lends itself well to the prediction of pharmaceutically relevant molecular parameters for which
211 synthesis of 32 (hetero)arylamines and their pharmaceutically relevant molecules (five) are described
212 tic moieties are recurrent in biological and pharmaceutically relevant molecules and constitute one o
213 ted prolinols, which are frequently found in pharmaceutically relevant molecules and organocatalysts.
214 d late-stage C-H alkylation of bioactive and pharmaceutically relevant molecules are advantages of th
215 bioactive motifs and expedient synthesis of pharmaceutically relevant molecules highlight the synthe
216 s methodology for the divergent synthesis of pharmaceutically relevant molecules, procedures for the
217 pplied to the tritiation of four halogenated pharmaceutically relevant molecules, resulting in predic
226 the late-stage isotopic labeling of various pharmaceutically relevant motifs and related scaffolds.
227 ntioselectivity outcomes for these valuable, pharmaceutically relevant motifs were remarkably accurat
232 lized to directly deliver a diverse array of pharmaceutically relevant N-trifluoromethyl pyrazoles in
233 tial mimetics of the hormone somatostatin, a pharmaceutically relevant natural peptide, which contain
235 native secondary amine substrates, including pharmaceutically relevant nitrogen heterocycles, is demo
236 l understanding and potential replacement of pharmaceutically relevant PEGs by alternative macromolec
237 programs identified active compounds from a pharmaceutically relevant pool of decoy compounds; howev
238 he first time, genetic accessibility of this pharmaceutically relevant producer strain by intergeneri
239 rovide a new approach for the preparation of pharmaceutically relevant products possessing tetrasubst
240 illion member DEL was screened against three pharmaceutically relevant protein targets, p38a, ACSS2,
241 ational methods on 150 crystal structures of pharmaceutically relevant protein-ligand complexes.
245 the protocol was exemplified by synthesizing pharmaceutically relevant scaffolds containing the N-alk
246 ps, supports late-stage functionalization of pharmaceutically relevant scaffolds, and is compatible w
248 isubstituted-alpha-tertiary amines featuring pharmaceutically relevant secondary amine cores with goo
249 these applications towards the synthesis of pharmaceutically relevant small molecules such as guaife
252 monitor molecular dynamic transitions in the pharmaceutically relevant solids Ambroxol and Ibuprofen.
253 e short synthesis of the central scaffold of pharmaceutically relevant Staphylococcus aureus Sortase
254 modulatory imide drugs form the core of many pharmaceutically relevant structures, but C(sp)(2)-C(sp)
256 tases (KREDs), enantioselectively reduce the pharmaceutically relevant substrates 3-thiacyclopentanon
257 ed yields for challenging cross-couplings of pharmaceutically relevant substrates compared with those
259 ification of natural products and drugs into pharmaceutically relevant sulfonamides and "clickable" s
262 study, we have applied XRD-CT to investigate pharmaceutically relevant tablets that have been subject
263 alyst and enabled rational modification of a pharmaceutically relevant target molecule to improve ena
265 s screened in comparative selections against pharmaceutically relevant targets and their closely rela
266 support the tenet that active compounds for pharmaceutically relevant targets can be successfully id
267 sion, these pathways can be considered to be pharmaceutically relevant targets for drug development i
272 oss-coupling methods that expand access to a pharmaceutically relevant three-dimensional chemical spa
273 cyclic triketones into structurally complex, pharmaceutically relevant tricyclic systems that combine
274 zed C-N couplings constructed using a large, pharmaceutically relevant, structurally diverse dataset
276 -9.8 muM, which covers the biologically (and pharmaceutically) relevant ranges, with a limit of detec
277 collaborative closed-loop optimisation for a pharmaceutically-relevant aldol condensation reaction in
278 thodology provides easy access to a class of pharmaceutically significant molecules and their precurs
279 y for the rapid assembly of biologically and pharmaceutically significant molecules, such as benzoxaz
280 being used in catalysis, green chemistry and pharmaceutically significant reactions are summarized in
281 chanisms of FXR regulation and in developing pharmaceutically suitable synthetic FXR ligands that mig
282 ing C3aR/C5aR activity either genetically or pharmaceutically suppressed OC generation, while stimula
284 strocyte biomarkers will make it possible to pharmaceutically target chemical pathways that preserve
285 and memory consolidation, and they have been pharmaceutically targeted for pain therapies, smoking ce
286 one-pot atom-economic single-step access to pharmaceutically targeted phosphorylated functionalized
288 of MaCSCs in breast cancer and suggest that pharmaceutically targeting these kinases may hold promis
290 d herein that blocking the PI3Kdelta pathway pharmaceutically to varying degrees can generate T cells
291 phenotypically screen, and thereby validate pharmaceutically tractable genes for drug development.
292 ol for the installation of other diverse and pharmaceutically useful isotopes, including carbon-14, c
293 of the clinically used antibiotics and other pharmaceutically useful natural products such as anthelm
298 atharanthus roseus that produces a number of pharmaceutically valuable, bioactive terpenoid indole al
299 our attempts to induce a Warburg-like state pharmaceutically via CPI-613 and PS48 treatment did augm