ライフサイエンスコーパス: pharmacological

1 clinical and theoretical to practical, that pharmacological 2-AG augmentation could represent a mech

2 protection is not conferred upon genetic or pharmacological abolition of the catalytic activity of H

3 Pharmacological abrogation of both the COX-2 and sEH pat

4 on worsens the severity of liver injury, its pharmacological activation by 6beta-ethyl-3a,7b-dihydrox

5 Pharmacological activation of AMPK using 5-aminoimidazol

6 Pharmacological activation of NRF2 (nuclear factor eryth

7 with this hypothesis, in anesthetized rats, pharmacological activation of P2Y(1) purinoceptors in th

8 We show that pharmacological activation of spinal NK1R and chemogenet

9 During in vitro fertilisation (IVF), pharmacological activation of the murine X chromosome-en

10 tested the prediction that NQO1 induction by pharmacological activation of the transcription factor n

11 Investigations of pharmacological activities of kenaf revealed that this e

12 The pharmacological activity and cellular permeability of th

13 -dimethyl moiety as a means of improving the pharmacological activity and physicochemical properties

14 which in the case of BCL6 leads to increased pharmacological activity compared to the effects induced

15 Furthermore, the pharmacological activity of JPH203, a specific inhibitor

16 biology supporting this extended duration of pharmacological activity.

17 eceptors are activated in vivo, complicating pharmacological advances.

18 tinued research of PF-5190457 as a potential pharmacological agent to treat alcohol use disorder.

19 itor of prostanoid biosynthesis, is a common pharmacological agent used for the management of pain, i

20 However, to date, pharmacological agents have failed to achieve significan

21 NSG mice may be a useful model to screen for pharmacological agents to blunt LV dysfunction and assoc

22 in the absence of repeated administration of pharmacological agents.

23 rrected by enhancing the glycolytic flux via pharmacological Akt or AMPK activation, thus providing a

24 Pharmacological AMPK activation by AICAR partially preve

25 We also describe the developments in pharmacological and electrophysiological therapies that

26 seeking, which may inform efforts to develop pharmacological and gene therapies for treating cocaine

27 behavioral deficits with high correlation by pharmacological and genetic approach.

28 In contrast, the pharmacological and genetic inhibition of BMI1 eliminate

29 Additionally, pharmacological and genetic inhibition of MNK-eIF4E sign

30 Pharmacological and genetic manipulation of mitochondria

31 Using microfluidics and pharmacological and genetic studies, we could recapitula

32 es, as well as behavioural interventions and pharmacological and neurosurgical therapies.

33 ve combined electrophysiological recordings, pharmacological and optogenetic manipulations, and an ad

34 Despite their pharmacological and physiological importance in the abso

35 are the primary drivers which determine the pharmacological and toxicological properties of gapmer A

36 Our pharmacological and transgenic animal studies find that

37 ed in combination with electrophysiological, pharmacological, and systems-level physiology experiment

38 The "shock-and-kill" pharmacological ap-proach aims to reactivate provirus ex

39 boxylesterases 1 and 2 and demonstrate their pharmacological application by optically controlling the

40 Our studies highlight a pharmacological approach to inhibit TEAD palmitoylation

41 pecific optogenetics, we employed a targeted pharmacological approach to interrogate synaptic mechani

42 The conventional pharmacological approach to mild asthma has long relied

43 Current surgical and pharmacological approaches are ineffective, and liver tr

44 Last, we demonstrated with pharmacological approaches that nitric oxide (NO) produc

45 s were combined with independent genetic and pharmacological approaches to show that embryonic photos

46 Non-pharmacological approaches to treatment have proven less

47 In this report, using genetic and pharmacological approaches, we demonstrate that whereas

48 Using genetic and pharmacological approaches, we show that depletion of th

49 boost the development of conformation-based pharmacological approaches.

50 y offers several advantages over traditional pharmacological based therapies, including the ability t

51 nal groups while providing a wide variety of pharmacological benefits bestowed by the C-F bond.

52 Pharmacological blockade and knockdown of the melanocort

53 Pharmacological blockade of ER stress in vitro using dex

54 In contrast, pharmacological blockade of estrogen synthesis or nuclea

55 Pharmacological blockade of HCN and SK activities mimick

56 Knocking out Nox4 in skeletal muscles or pharmacological blockade of Nox4 activity abrogated tumo

57 gether, our findings provide a rationale for pharmacological blockade of the AXL signaling axis in PI

58 P production and AML cell proliferation, and pharmacological blockade of the vitamin B6 pathway at bo

59 endent of protein synthesis but sensitive to pharmacological blockade of transforming protein RhoA ac

60 egeneration, which are rescued by genetic or pharmacological blockade of TRPV4 channel activity.

61 Unexpectedly, pharmacological blockade or genetic deletion of CB1, CB2

62 For pharmacological blockade, we engineered a bispecific rec

63 function was reduced by administration of a pharmacological blocker and when CFTR was fully function

64 Pharmacological CatC inhibition could be a potential the

65 inical and preclinical studies indicate that pharmacological CDK4/6 inhibitors are only modestly effe

66 Pharmacological characterization of MP135 supports the u

67 ds are urgently required for improving their pharmacological characterization.

68 Pharmacological co-inhibition of YAP and TEAD, or geneti

69 Pharmacological co-targeting of MEK1/2, HDAC3, and G9a s

70 The pharmacological concept of functional selectivity (aka b

71 It provides new pharmacological content, including molecular targets in

72 Pharmacological control of myosin isoforms is a promisin

73 We conclude that pharmacological CSF1R inhibitors afford the most extensi

74 In the absence of a pharmacological cure, finding the most sensitive early c

75 Pharmacological degradation of BRD4-NUT results in colla

76 g top crucial factors in cancer progression, pharmacological disruption of this pivotal axis could se

77 Although pharmacological Drp1 inhibition has been put forward as

78 resent work provides novel insights into the pharmacological effects that bupropion exerts on heterom

79 oids and phenolics which have several proven pharmacological effects.

80 amount of attention because of its promising pharmacological effects.

81 olds promise as a means to reduce off-target pharmacological effects.

82 Pharmacological elevation of circulating AKG induces mus

83 Moreover, pharmacological elevation of membrane PI(4,5)P2 in cultu

84 s downregulated after repeated seizures, and pharmacological enhancement of AEA signaling rescued sei

85 dimeric quadruplexes, but their preclinical pharmacological evaluation is limited.

86 of ECs in the developing embryo and provide pharmacological evidence for a role of Src family kinase

87 Pharmacological evidence indicated involvement of both m

88 gical, immunohistochemical, biochemical, and pharmacological experiments revealed that inhibition of

89 be determined by other bacterial, host, and pharmacological factors.

90 display distinct structural, functional, and pharmacological features than their neuronal counterpart

91 t cellular transport systems and exploitable pharmacological features.

92 Intriguingly, pharmacological FOXO1 inhibition also attenuated DOX-ind

93 Pharmacological HIV-1 reactivation to reverse latent inf

94 Pharmacological immune checkpoint blockade has revolutio

95 Direct pharmacological inactivation of parietal cortex increase

96 uced by store depletion were both reduced by pharmacological inhibition and PKCdelta knockdown.

97 erved upon siRNA-mediated IKBKE depletion or pharmacological inhibition due to inhibited AR gene expr

98 MLK3 loss or pharmacological inhibition induces activation of T cells

99 hannel by mild depletion of its c-subunit or pharmacological inhibition normalizes stimulus-induced a

100 ed down-regulation of an actin regulator, by pharmacological inhibition of actin polymerization, and

101 Accordingly, pharmacological inhibition of ADORA1 or AKT signaling ca

102 In addition, the pharmacological inhibition of AMD1 by AO476 treatment re

103 reactivation in the intestinal epithelium or pharmacological inhibition of ATM, YAP1, or caspase-1 as

104 Sustained pharmacological inhibition of autophagy using Chloroquin

105 ell death and were resensitized to BBR after pharmacological inhibition of beta-catenin.

106 Pharmacological inhibition of BMP signaling protects hum

107 Pharmacological inhibition of BRD4 decreased NRP1 expres

108 We tested the hypothesis that genetic or pharmacological inhibition of CETP would preserve high-d

109 e clinical and preclinical data suggest that pharmacological inhibition of CHIT1 might represent a no

110 pic bands and mutants are less responsive to pharmacological inhibition of cholecystokinin-containing

111 Knockdown or pharmacological inhibition of CSNK1A1 attenuates PDAC ce

112 ndent suppression of mTORC1 was abrogated by pharmacological inhibition of DGAT1 or DGAT2, isoenzymes

113 We conclude that transient pharmacological inhibition of DNA-PKcs activity is effec

114 We further found that pharmacological inhibition of downstream effectors of th

115 In mice, genetic ablation or selective pharmacological inhibition of FAAH bidirectionally dysre

116 In slices from naive animals, pharmacological inhibition of G-protein receptor kinase

117 In the presence of BFT, pharmacological inhibition of GCS caused levels of tight

118 Pharmacological inhibition of GSK3 enhanced Nrf2 activit

119 Pharmacological inhibition of GT1b synthesis attenuates

120 Of particular interest, pharmacological inhibition of histone deacetylase 11 (HD

121 Pharmacological inhibition of HSP90 reversed these effec

122 Accordingly, genetic and pharmacological inhibition of HuR had potent cytostatic

123 We examined the effects of genetic or pharmacological inhibition of IFN-beta, a key component

124 Pharmacological inhibition of KDM6A also impairs chemoth

125 Like nitric oxide, pharmacological inhibition of mitochondrial oxidative me

126 e transfer of Pink1-deficient bone marrow or pharmacological inhibition of mitophagy promoted macroph

127 The effect of genetic and pharmacological inhibition of myostatin signalling on th

128 Consistent with this mechanism, pharmacological inhibition of NER using spironolactone a

129 We used genetic and pharmacological inhibition of NMT1 to further dissect th

130 In addition, 4-AP treatment with pharmacological inhibition of p53-dependent motor neuron

131 Furthermore, pharmacological inhibition of PGE2 synthesis and PGE2 re

132 Pharmacological inhibition of phosphatidylinositol kinas

133 storation of ApoE efflux was not affected by pharmacological inhibition of PPARgamma activity, and sp

134 In the pristane-induced murine lupus model, pharmacological inhibition of SphK1 or its genetic delet

135 ch behavior in male and female mice, whereas pharmacological inhibition of spinal NK1R suppresses itc

136 Pharmacological inhibition of Src or overexpression of a

137 Acute pharmacological inhibition of the anandamide-degrading e

138 and behavioral deficits could be rescued by pharmacological inhibition of the eIF4G1 function and ch

139 Pharmacological inhibition of the mitogen-activated prot

140 in the rule-shifting task while genetic and pharmacological inhibition of the MNK-eIF4E signaling ax

141 the present study, we analyzed the effect of pharmacological inhibition of the NLRP3 inflammasome usi

142 Pharmacological inhibition of the TLR4 pathway using a s

143 Genetic or pharmacological inhibition of the TMEM173-GSDMD-F3 pathw

144 Genetic and pharmacological inhibition of this pathway prevents brea

145 Pharmacological inhibition of three other RNA interactom

146 Finally, pharmacological inhibition of TRPM3 dampened TRPV1- and

147 Further, pharmacological inhibition of two negative regulators of

148 Pharmacological inhibition of USP7 resensitized chemores

149 the tPA reduction with exogenous tPA or with pharmacological inhibition or genetic deletion of PAI-1

150 Pharmacological inhibition or phagocyte-specific deficie

151 Furthermore, knockout of TSP2, or pharmacological inhibition or viral-mediated knockdown o

152 However, previous pharmacological inhibition studies in the annelid Capite

153 disparate growth effects observed with RNAi, pharmacological inhibition, and CRISPR remain unclear.

154 ostaining, deep confocal imaging, and staged pharmacological inhibition, we define the cell behaviors

155 , using both a genetic knockout approach and pharmacological inhibition, we establish LdHSP78 as a dr

156 daptor spleen tyrosine kinase (Syk), and Syk pharmacological inhibition.

157 Inhibition of PDGFRbeta using a pharmacological inhibitor and siRNAs blocked TGFbeta-sti

158 Using small pharmacological inhibitors and gene silencing, we establ

159 In a search for pharmacological inhibitors of SOX10, we performed a mass

160 ite-responsive T-cell clones activated via a pharmacological interactions pathway in patients with li

161 lar considerations related to marijuana use, pharmacological interactions, and future steps to provid

162 rate coefficients of very slow processes of pharmacological interest.

163 Genetic and pharmacological interference with ethylene and auxin pat

164 Thus, pharmacological interference with the ISR emerges as a p

165 ide a blueprint for targeting ferroportin in pharmacological intervention of ferroportin diseases.

166 Furthermore, genetic or pharmacological intervention of the MCP1-CCR2 chemoattra

167 ry endpoints were the effects of dietary and pharmacological intervention on stool calorie loss.

168 Genetic manipulation of MCs, pharmacological intervention targeting MC degranulation

169 e longitudinal trajectories before and after pharmacological intervention.

170 ma, making it potentially a valid target for pharmacological intervention.

171 g infarct size reduction with mechanical and pharmacological interventions and the poor translation i

172 ctional brain connectomic changes during non-pharmacological interventions for amnestic mild cognitiv

173 ssess the effectiveness of psychological and pharmacological interventions for managing mental health

174 Here, we assessed the effects of different pharmacological interventions on the aggregation and int

175 Our overall aim is to suggest that pharmacological interventions targeting lysosomal functi

176 Non-pharmacological interventions to manage the risk of frac

177 lore their modifiability through dietary and pharmacological interventions.

178 In combination with pharmacological JAK inhibition, YBX1 inactivation induce

179 Pharmacological JNK2 inhibition produced results qualita

180 termining the clinical utility and safety of pharmacological knockdown of HDAC8 in diseased cells.

181 should be prescribed to all patients, while pharmacological management is reserved for patients who

182 source of heterogeneity in old HSCs, and its pharmacological manipulation can alter transcriptional p

183 dicating that even a well-defined genetic or pharmacological manipulation may produce qualitatively d

184 itic voltage-gated calcium channels (VGCCs): pharmacological manipulation of L-type VGCCs reversed co

185 Piggyback multibarrel electrodes enabled pharmacological manipulation of nAChRs by reversibly app

186 In contrast, pharmacological manipulation offers the promise of targe

187 Using a pharmacological manipulation, we show that the activity

188 Using optogenetic and pharmacological manipulations in male mice, we show that

189 In this study, we demonstrate that pharmacological manipulations that increase the availabi

190 ossibility for subtype-specific targeting by pharmacological means for treatment of neurological dise

191 Newer agents likewise exploit these pharmacological mechanisms, including tramadol (mu-opioi

192 ventions have been shown to be effective non-pharmacological methods for improving social participati

193 Pharmacological modulation of class I histone deacetylas

194 at and will help to identify targets for the pharmacological modulation of related pathologic behavio

195 e psychedelic state and, more generally, the pharmacological modulation of whole-brain activity.

196 al sampling models can inform the effects of pharmacological modulation on choice processes.

197 r complexes and discuss strategies for their pharmacological modulation.

198 We conclude that a pharmacological modulator can elicit opposite regulatory

199 nisms by which heat, mechanical stretch, and pharmacological modulators alter TREK1 channel activity

200 d enabled us to assess various molecular and pharmacological modulators of the FAO pathway in establi

201 actomes are aiding the development of direct pharmacological modulators.

202 ctional roles, mechanisms of activation, and pharmacological modulators.

203 cuss approaches such as neurostimulation and pharmacological neuromodulation to reduce tissue inflamm

204 Pharmacological options for treating bipolar disorder ha

205 by pairing brief monocular stimulation with pharmacological or chemogenetical activation of Gs- or G

206 Pharmacological or genetic ablation of large conductance

207 Pharmacological or genetic inhibition of the endothelial

208 Pharmacological or genetic suppression of innate immune

209 eby substantial improvements in a variety of pharmacological parameters can be achieved.

210 nist potency, binding affinity, and relevant pharmacological parameters of 15 candidates were investi

211 and an analysis framework to extract kinetic pharmacological parameters.

212 Genetic or pharmacological perturbation of cellular machinery invol

213 l experiments based on genetic, surgical and pharmacological perturbations are being produced at an e

214 Genetic and pharmacological perturbations demonstrated that PPARalph

215 We exposed cells to mechanical, genetic, and pharmacological perturbations, mimicking a range of phys

216 , and we describe responses to metabolic and pharmacological perturbations.

217 Strikingly, genetic or pharmacological PGM3 inhibition reduces PC cell growth,

218 ta(1)-AR activation, but was abolished after pharmacological PKA inhibition and thus potentially attr

219 the oldest drugs (in use since 1500 BC), its pharmacological potential as a lead structure is not yet

220 molecules will enable further study of their pharmacological potential.

221 mising MOR-biased ligands and assessed their pharmacological profile against existing opioid analgesi

222 scovery of molecules with the most desirable pharmacological profile for the correction of heart fail

223 cocaine and methylphenidate but has a unique pharmacological profile that includes facilitation of el

224 ead compounds can have meaningful impacts on pharmacological profiles due to significant effects on m

225 in vitro testing revealed favorable ADME and pharmacological profiles for the best compound 19.

226 approach to enediyne ADC creation, while the pharmacological profiles of at least two of the generate

227 elective GABA(A)R modulators will have novel pharmacological profiles.

228 has hampered studies of its biophysical and pharmacological properties and the development of high-t

229 haracterize their physicochemical, ADME, and pharmacological properties and their preliminary toxicol

230 in vivo metabolism as well as improve other pharmacological properties has led to numerous innovativ

231 tum evoke DA signals with unique spatial and pharmacological properties that likely shape their funct

232 eric modulators and exhibit a broad range of pharmacological properties, altering both receptor signa

233 -cyc(Dap6E10), was found to possess superior pharmacological properties, including improved resistanc

234 In this Review, we highlight the emerging pharmacological rationale and clinical development of du

235 LVAD speed was optimized with an aggressive pharmacological regimen, and regular echocardiograms wer

236 ms of the possible underlying mechanisms and pharmacological relevance.

237 after controlled cortical impact in mice by pharmacological removal of chronically activated microgl

238 e forebrain show hyperactivity and ADHD-like pharmacological responses to D-amphetamine.

239 Pharmacological restoration of lysosomal biogenesis thro

240 issemination could be effectively blocked by pharmacological ROCK1 inhibition using Fasudil.

241 Pharmacological selective inhibition of hOAT has been sh

242 Non-pharmacological self-help interventions, such as bibliot

243 lls may effectively mitigate CIPN, we used a pharmacological 'senolytic' agent, ABT263, which inhibit

244 ic markers; electrophysiological properties; pharmacological sensitivities; and more recently, transc

245 We asked whether pharmacological stimulation of endogenous neural precurs

246 Numerous pharmacological strategies have attempted to prevent fib

247 e images in infants with the sole use of non-pharmacological strategies.

248 her, these results uncover a potential novel pharmacological strategy against this disease through th

249 Thus, we describe a pharmacological strategy that interferes with Notch sign

250 ad body mass index >=30 kg/m(2), and 71% had pharmacological stress.

251 Pharmacological studies have demonstrated that inhibitio

252 inhibitory effects of tetrodotoxin (TTX) in pharmacological studies.

253 randomized, placebo-controlled, double-blind pharmacological study testing the impact of three differ

254 ator of kinase activity, which may provide a pharmacological target for modulating CaMKII activity.

255 s whether modifying pores could be used as a pharmacological target in HF.

256 We posit that these advances in pharmacological targeting of DUBs establish the enzyme f

257 Pharmacological targeting of messenger RNA represents an

258 These studies suggest that pharmacological targeting of OCT2 could be exploited to

259 The results also suggest that pharmacological targeting of PRL2 could provide a novel

260 Pharmacological targeting of REVERBalpha inhibited myofi

261 Recent evidence suggests that pharmacological targeting of specific proteins during di

262 dentify highly conserved signaling pathways, pharmacological targeting of which substantially delays

263 CAR T-cell cytotoxicity, with potential for pharmacological targeting to enhance cancer immunotherap

264 in the brain and have been recognized as key pharmacological targets for pain.

265 However, only a handful of these potential pharmacological targets have been tested.

266 f diagnostic/prognostic biomarkers and novel pharmacological targets.

267 The most common non-pharmacological technique included feeding and swaddling

268 Pharmacological tests in vitro revealed that attachment

269 his paper summarizes current and prospective pharmacological therapies for treating both EDS and cata

270 pitalization in older adults, and studies of pharmacological therapies have yielded limited progress

271 Physical activity is recommended as a non-pharmacological therapy in both obese and cancer situati

272 ) trafficking corrector could serve as a new pharmacological therapy of both congenital and drug-indu

273 eatment with comprehensive disease-modifying pharmacological therapy was estimated to afford 2.7 addi

274 ravel and productivity costs) in addition to pharmacological therapy, assuming a 9-year horizon to ca

275 langitis, a disease so far lacking effective pharmacological therapy.

276 We sought to determine what pharmacological thresholds correspond to exercise pathop

277 brain-penetrant GPR52 agonist as a valuable pharmacological tool for investigating the physiological

278 helium; agonism of PPARalpha with genetic or pharmacological tools ameliorates inflammation, vascular

279 tivity over the antitarget M(2) are valuable pharmacological tools and may enable improved treatment

280 EPAC1 activators may therefore act as useful pharmacological tools for elucidation of EPAC function a

281 dimeric model of LDH-H, constitute promising pharmacological tools for the de novo design and identif

282 Pharmacological tools specifically targeting TMEM16 CaPL

283 oreover, the potential of targeting PKC with pharmacological tools to inhibit pathologic fibrosis has

284 Ds in neurons has been hindered by a lack of pharmacological tools.

285 s had relatively large variations during non-pharmacological training, which might provide distinct b

286 The stepwise approach to pharmacological treatment in adult asthma mandates that

287 providing a new direction for research into pharmacological treatment of humans with dementia.

288 rplay among cell types, and tested potential pharmacological treatment strategies to retard its progr

289 Here, we report the discovery of a pharmacological treatment that thins F-actin bands, depl

290 abilizer (-)-OSU6162 may serve as an adjunct pharmacological treatment to prevent relapse in male opi

291 Compared with pharmacological treatment, AF ablation was associated wi

292 Unfortunately, effective pharmacological treatments for bipolar disorders are not

293 Pharmacological treatments for non-alcoholic steatohepat

294 The most frequently used pharmacological treatments include oral, intranasal or o

295 diverticular disease include dietary fibre, pharmacological treatments such as antibiotics (rifaximi

296 Here, we use pharmacological treatments to highlight the role that th

297 Disease characteristics, pharmacological treatments, and health-related QoL of pa

298 ar assays, and tolerated drugs in subsequent pharmacological treatments.

299 eptides/proteins targeting pharmaceutical or pharmacological utilizations.

300 Synthesis and analysis of pharmacological variants of DIDS suggested that intrinsi