ライフサイエンスコーパス: pharmacology

1 re rare (e.g., search for effective drugs in pharmacology).

2 e possibilities of cell-specific imaging and pharmacology.

3 erapeutics exhibiting ferrous iron-dependent pharmacology.

4 r the MC3R over the muM MC4R partial agonist pharmacology.

5 and-gated chloride channels with a very rich pharmacology.

6 chanism-based disease definition for network pharmacology.

7 d suitable synergistic cotargets for network pharmacology.

8 based on calorie reduction and exercise, or pharmacology.

9 biology allow better characterization of SLC pharmacology.

10 ling pathways, is currently at the center of pharmacology.

11 nists may play a role in NOP receptor ligand pharmacology.

12 but requires careful evaluation of the TRPA1 pharmacology.

13 sumption was evaluated through site-directed pharmacology.

14 mGluRs, and substantially altering synaptic pharmacology.

15 targets for systems medicine-driven network pharmacology.

16 described by theoretical models of receptor pharmacology.

17 the gating mechanism of human TRPM2 and its pharmacology.

18 ional food products, dietary supplements and pharmacology.

19 es of kidney function, disease modeling, and pharmacology.

20 c investigations of GABAergic signalling and pharmacology.

21 ug treatments, including with regard to drug pharmacology.

22 on Kv1.1 (KCNA1) gating, ion selectivity, or pharmacology.

23 xtended duration of action and more profound pharmacology.

24 ls by a combination of electrophysiology and pharmacology.

25 arch of chemical biology and is essential in pharmacology.

26 to search for Gs- and Golf-specific receptor pharmacology.

27 and uncovers an alternative endocannabinoid pharmacology.

28 compound in both chemical structure and AHR pharmacology.

29 d to identifying new molecules with a select pharmacology.

30 plications in drug development and molecular pharmacology.

31 new and improved drugs with less off-target pharmacology.

32 tivity at the MC5R, the first report of this pharmacology.

33 it maintains a rich and multifaceted steroid pharmacology.

34 kotriene CysLT1) to reconstitute the elusive pharmacology.

35 ty in determination of Kir channel inhibitor pharmacology.

36 as such as medical science, diagnostics, and pharmacology.

37 of Galpha subunit-specific effects on opioid pharmacology.

38 on and may hold implications for TH and PPAR pharmacology.

39 pharmacodynamics (PK/PD) and systems biology/pharmacology.

40 dose-response relationship in toxicology and pharmacology.

41 pport a better understanding of Class F GPCR pharmacology.

42 ell RNA sequencing, CRISPR interference, and pharmacology.

43 ed toxinology, biochemistry, toxicology, and pharmacology.

44 ruct in analyses of multiple aspects of GPCR pharmacology.

45 hich complicates the interpretation of their pharmacology.

46 ing small molecules and biologics with novel pharmacology.

47 ce in stereochemistry, molecular biology and pharmacology(2).

48 ide detailed mechanistic insights into NMDAR pharmacology, activation, and inhibition, which are fund

49 e detailed insights into Na(v)1.5 structure, pharmacology, activation, inactivation, ion selectivity,

50 to several disciplines such as microbiology, pharmacology, agriculture, and pathogenesis.

51 Knowledge of lead pharmacology allows us to better understand its absorpti

52 Over the past 50 years in pharmacology, an understanding of seven transmembrane (7

53 All of the systems pharmacology analyses and results will shed light insigh

54 own structure and concentration for in vitro pharmacology and absorption, distribution, metabolism, a

55 ts' clinical and procedural characteristics, pharmacology and access site had the highest relative im

56 The novel pharmacology and aqueous humor dynamic effects of this m

57 facilitated by a better understanding of the pharmacology and behavioral effects of opioids that unde

58 cle, we review the available evidence on the pharmacology and behavioral interactions of THC and CBD

59 Using a combination of electrophysiology, pharmacology and biochemistry, we show that changes in D

60 licit, providing valuable insights into CCR5 pharmacology and cell biology that will facilitate the d

61 ehavioral expression using receptor-specific pharmacology and cell- and projection-specific chemogene

62 tions suggest that Galphaz may impact opioid pharmacology and cellular physiology more than previousl

63 s a representative of the series in terms of pharmacology and demonstrated the desired estrogen recep

64 hibitors of this highly attractive target in pharmacology and dermocosmetics.

65 has implications for CRAC channel function, pharmacology and disease-causing mutations.

66 We review recent applications to pharmacology and drug discovery and discuss possible gui

67 to identify off-targets, and to explain poly-pharmacology and drug toxicity.

68 this hyperlocomotion follows zebrafish TRPA1 pharmacology and evaluated the strengths and limitations

69 ative mass spectrometry are now transforming pharmacology and experimental biology more broadly.

70 The American Society for Pharmacology and Experimental Therapeutics has revised t

71 Drug Metabolism and Disposition, Journal of Pharmacology and Experimental Therapeutics, and Molecula

72 An integrated network pharmacology and experimental verification approach was

73 to guide meaningful investigations into the pharmacology and function of individual receptors.

74 cence-based Ca(2+) flux assays combined with pharmacology and gene knock-out methods, we discovered a

75 A unique resource for systems pharmacology and genomic studies is the NCI-60 cancer ce

76 and expanded classical concepts of receptor pharmacology and have begun to illuminate the distinct m

77 ke defect, including timed injection series, pharmacology and ion replacement, and optogenetic activi

78 to speed up our understanding of 5-HT(2A)R's pharmacology and its characteristic behavioral outputs i

79 sing, surprisingly little is known about THC pharmacology and its effects on behavior and brain activ

80 It has rich pharmacology and largely accounts for the recreational u

81 ancer research, transplantation, physiology, pharmacology and mechanical ventilation.

82 portant to the fields of biology, chemistry, pharmacology and medicine.

83 Here, we use tissue-specific pharmacology and metabolic tools to clarify the roles of

84 tofluidic neural probes for advanced in vivo pharmacology and optogenetics in freely moving rodents.T

85 lug-like drug cartridges for chronic in vivo pharmacology and optogenetics with selective manipulatio

86 ll of which helps to understand the puzzling pharmacology and pathophysiology of this channel.

87 mising approach to enhance active ingredient pharmacology and pharmacodynamics.

88 Medicine (TCM), results in great changes in pharmacology and pharmacodynamics.

89 modifications on myricetin might improve its pharmacology and pharmacokinetics.

90 Plume pharmacology and plume-like neural Ca(2+) events were co

91 The unique pharmacology and restricted biodistribution of nanobody

92 ructural modifications profoundly impact its pharmacology and result in large numbers of useful pharm

93 egulates GABA(A)R trafficking, function, and pharmacology and reveal a previously unknown molecular i

94 d techniques to further interrogate hA(2A)AR pharmacology and signaling.

95 monstrate that drug design affected receptor pharmacology and suggest that the MMC scaffold is a usef

96 we present an in-depth discussion on how TB pharmacology and the related strategies will contribute

97 for by updates from the IUPHAR/BPS Guide to Pharmacology and the Therapeutic Target Database.

98 unoresolvents as agonists to test resolution pharmacology and their role in catabasis for their thera

99 on with the cell membrane lipid bilayer, the pharmacology and toxicology in vitro and in vivo (mice a

100 ment, developmental disorders, developmental pharmacology and toxicology, and drug screening.

101 Pharmacology and tracer permeability rule out coupling b

102 We used chemogenetics, optogenetics, pharmacology, and a translationally analogous Pavlovian-

103 on and expansion study evaluated the safety, pharmacology, and activity of varlilumab in patients wit

104 By combining imaging, whole-cell recording, pharmacology, and anatomical techniques, we found that f

105 nderlying pathophysiology, relevant clinical pharmacology, and anecdotal experience.

106 idates distinct tissue-specific modulations, pharmacology, and disease pathogenesis of K(V)7.1, and l

107 Combining genetics, pharmacology, and electrophysiology, we find that a sign

108 derstand binding modes, mechanism of action, pharmacology, and even facilitate structure elucidation.

109 exploiting AKAPs as platforms for precision pharmacology, and explore the impact of methodological i

110 erformed to assess mobility in cell biology, pharmacology, and food science.

111 hnology, such as target engagement, receptor pharmacology, and high-throughput screening.

112 tal and underlying role in chemical biology, pharmacology, and medicine to discover safe and efficaci

113 fields of research, including geochemistry, pharmacology, and medicine.

114 ceptor complex with altered gating kinetics, pharmacology, and pore properties.

115 further comprehensively including precision pharmacology, and within this framework, articulating it

116 l basis of TRP channel gating mechanisms and pharmacology, and, despite the large number of structure

117 We illustrate how a systems pharmacology approach combining experimental and computa

118 ug-abuse chemogenomics-knowledgebase systems pharmacology approach to conduct targets/off-targets map

119 It uses a systems pharmacology approach to infer the combinatorial drug ef

120 f novel anti-fibrotic therapies in a network pharmacology approach.

121 s for drug administration and proper systems pharmacology approaches for patient data analysis.

122 nism behind our findings, we applied systems pharmacology approaches to investigate the crosstalk bet

123 ts a major area of focus in studies of basic pharmacology as well as drug development, largely due to

124 genetic results using automated, behavioral pharmacology assays showed that ogt-1 and eel-1 act in p

125 on 23 (Cys23Ser) appears to impact 5-HT(2C)R pharmacology at a cellular and systems level.

126 provides a new strategy to investigate mu-OR pharmacology at single-molecule level.

127 Modeling and pharmacology-based approaches to improve insulin action

128 In classical pharmacology, bioassay data are fit to general equations

129 chemogenetics, fast scan cyclic voltammetry, pharmacology, biochemistry, and cocaine self-administrat

130 ely to find applications in cell biology and pharmacology by allowing label-free quantification of mi

131 es KCNQ channel ion selectivity, gating, and pharmacology by direct physical interaction with the por

132 This special issue of Molecular Pharmacology celebrates these 50 years of opioid researc

133 marize their unique screening strategies and pharmacology considerations.

134 vity, sensitivity to extracellular K(+), and pharmacology, consistent with an impact on conformation

135 ing and an improved understanding of A(2A)AR pharmacology could promote development of more efficacio

136 we combined double-blind, placebo-controlled pharmacology [D2 receptor (D2R) antagonist amisulpride]

137 By applying a novel systems pharmacology data analysis framework, 3 commonly used AR

138 Together with multichannel pharmacology data, this model predicts that compounds wi

139 APD and Q-T intervals as criteria for safety pharmacology decisions.

140 hibitors have progressed to the clinic where pharmacology-driven adverse events have been reported.

141 ronized to therapeutic inputs such as EES or pharmacology, during body weight supported treadmill or

142 the concept of "redox cycling"), biochemical pharmacology (ebselen), nutritional biochemistry and mic

143 Using live-cell fluorescence imaging, pharmacology, electrophysiology, and genetic manipulatio

144 ated by designer drugs (DREADDs), behavioral pharmacology, electrophysiology, and immunoelectron micr

145 f-concept study demonstrates that behavioral pharmacology endpoints of alcohol-induced stimulation, s

146 Pharmacology experiments (mouse) and RNA sequencing (hum

147 aining system with wireless optogenetics and pharmacology experiments, expanding the breadth of exper

148 Our aim was to investigate the receptor pharmacology, expression pattern, and in vivo function o

149 over cell-type-specific neural circuitry and pharmacology for appetite control within the DRN.

150 In this study, we present a systems pharmacology framework which draws on genetic data from

151 molecules, along with the issues relating to pharmacology, has left integrin therapeutics in need of

152 sed cardiovascular procedures and adjunctive pharmacology have an inherent risk of neurological compl

153 We discuss here how recent trends in cancer pharmacology have confronted these challenges, positioni

154 t advances in biology, optics, genetics, and pharmacology have resulted in the emergence of novel and

155 n, we consider how evolving concepts of GPCR pharmacology have shaped understanding of the complex ph

156 To support the emerging field of 'resolution pharmacology', here we discuss the scientific strategies

157 c target for neuropsychiatric disorders; its pharmacology, however, remains scarcely understood.

158 ytes that may become a great tool for safety pharmacology; however, their electrical phenotype is imm

159 cations tested for AUD using both behavioral pharmacology (i.e., alcohol administration) and randomiz

160 Here, we used classical pharmacology, immunohistochemistry, and retrograde traci

161 G channel interactions and multi-ion channel pharmacology improves the prediction of torsadogenic ris

162 nstrates the potential of structural systems pharmacology in designing polypharmacology for precision

163 hlights the significant potential of systems pharmacology in elucidating the mechanism of synergy and

164 ch to engineer specific and photo-reversible pharmacology in GluD2 receptor.

165 ging interpretations of NAADP physiology and pharmacology in heart.

166 lele, which could impact aspects of receptor pharmacology in individuals expressing the Cys23Ser SNP.

167 provides a comprehensive evaluation of their pharmacology in numerous endocrine-resistant BC models a

168 Using occlusion experiments and pharmacology in patched pairs of coupled neurons in vitr

169 Using pharmacology in Peromyscus and chemogenetics in Mus, we

170 bition, free energy landscapes, and targeted pharmacology in precision medicine.

171 s discuss chloroquine and hydroxychloroquine pharmacology in the context of possible treatment of SAR

172 wed studies in cardiovascular physiology and pharmacology in the year 2018 were systematically review

173 of human heart morphology, biochemistry and pharmacology in vitro, offering a promising alternative

174 Finally, by combining recordings and pharmacology in vivo, in slices, and in human embryonic

175 Here, we used classical pharmacology, in situ hybridization, immunohistochemistr

176 rotonin transporter (SERT/SLC6A4) has a rich pharmacology including inhibitors, releasers (amphetamin

177 emerging roles for selected OATPs in cancer pharmacology, including preclinical and clinical studies

178 derstanding peripheral nerve homeostasis and pharmacology, including targeted drug delivery and the m

179 cannabinoids, unique natural products, whose pharmacology is going to gain increasing interest in the

180 Interventional pharmacology is one of medicine's most potent weapons ag

181 porter families, a detailed insight into the pharmacology is still relatively sparse.

182 -permeant neutral CB1 antagonist, though its pharmacology is still unclear.

183 g together during the International Union of Pharmacology meeting in Basel in 1969, recognized that t

184 This computational systems pharmacology model captures the ability of the ECM to re

185 in an in vivo delayed-type hypersensitivity pharmacology model in rats.

186 A system pharmacology model of TB infection, and drug therapy was

187 Quantitative pharmacology models that integrated cellular PTX pharmac

188 evelop computational predictive quantitative pharmacology models.

189 Here, we used selective pharmacology, molecular and genetic approaches to implic

190 hich itself gives rise to the complex opioid pharmacology observed at the cellular and behavioral lev

191 ignificant new knowledge about the molecular pharmacology of a diverse range of clinically relevant N

192 Finally, we applied SYSMOLE to study the pharmacology of a new class of glutamate antipsychotic d

193 ally influence the distribution, gating, and pharmacology of AMPARs, but the contribution of these au

194 The conservation and divergence in the pharmacology of bacterial and mammalian Na(V) channels p

195 However, the pharmacology of bacterial Na(V) remains largely unexplor

196 provides new insights into the function and pharmacology of both the CAN and the TRPM families.

197 subunits and the molecular dissection of the pharmacology of BZDs indicates that subtype-selective GA

198 9) provide unique snapshots of the molecular pharmacology of cannabinoids.

199 sults improve understanding of the molecular pharmacology of CCR5 and help further elucidate the inhi

200 Mechanistic studies might help advance the pharmacology of depression by identifying pathways throu

201 Our study shows the pharmacology of E(4) and BMI-135 as less-potent full-est

202 ous inhibitory Galpha subunits influence the pharmacology of full and partial agonists at the kappa o

203 has long been hypothesized that function and pharmacology of GABA(A)Rs are determined by the channel

204 The function and pharmacology of gamma-aminobutyric acid type A receptors

205 croPatch 768PE) to investigate the molecular pharmacology of GS-967 and eleclazine on peak sodium cur

206 We investigated the molecular pharmacology of GS-967 and eleclazine on sodium channels

207 In this review, the pharmacology of hallucinogenic compounds is summarized b

208 We demonstrate that the pharmacology of ion channel and GPCR ligands as determin

209 The pharmacology of molecules selected based on these predic

210 The pharmacology of NALCN is further delineated by a walled-

211 , we have analysed postsynaptic function and pharmacology of neuronal nicotinic ACh receptors (nAChRs

212 important tool in understanding the in vivo pharmacology of novel drugs engaging the GCGR.

213 expert consensus provides an overview of the pharmacology of P2Y12 inhibitors, different modalities a

214 The spinal pharmacology of pathways that subserve DNIC are complica

215 This emerging pharmacology of receptor-associated proteins provides a

216 ogy have shaped understanding of the complex pharmacology of receptors that recognize and are activat

217 Herein, we review the chemistry and pharmacology of reported ABAD inhibitors.

218 pound 27 may be a useful tool to explore the pharmacology of selective PDE2a inhibition.

219 first detailed mechanistic insight into the pharmacology of SLC11/NRAMP transporters.

220 extensive characterization of the molecular pharmacology of the most widely used CB2R ligands to dat

221 orted assay system faithfully replicates the pharmacology of the receptor in response to known agonis

222 tiated by what we know of the physiology and pharmacology of the receptor?

223 physiology, pathophysiology, toxicology, and pharmacology of the renal proximal tubule.

224 nd research on all elements of the molecular pharmacology of these molecules.

225 Determining the molecular identity and the pharmacology of these receptors is essential to define t

226 In recent times it has become clear that the pharmacology of these receptors is far more complex than

227 Further understanding of the complex pharmacology of these receptors will be critical to unlo

228 ies that incorporate glucagon agonism in the pharmacology of treating diabetes.

229 nced our understanding of the physiology and pharmacology of vasoprotective axis in bone marrow-deriv

230 in ortholog HSP-16.48 Using a combination of pharmacology, optogenetics, and phenotypic analyses we d

231 etabotropic glutamate receptor 3 (mGluR3) by pharmacology or genetics is associated with differences

232 Behavioral pharmacology paradigms have been used for early efficacy

233 ain characteristics of NQO2 from a molecular pharmacology perspective.

234 frequently published in the subject areas of pharmacology, pharmacy, oncology, and medicinal chemistr

235 eative minds across the fields of chemistry, pharmacology, physiology, and behavior in the study of o

236 We develop a novel structural systems pharmacology platform 3D-REMAP that uses ligand binding

237 RELN levels using transgenesis or prefrontal pharmacology prevents the pHFD-induced prefrontal cognit

238 ble applications in bioscience, medicine and pharmacology previously not possible.

239 ome selective, and having an improved safety pharmacology profile.

240 Quantitative Systems Pharmacology (QSP) is a drug discovery approach that int

241 ression, we developed a quantitative systems pharmacology (QSP) model of hematopoiesis in vitro for q

242 We developed a quantitative systems pharmacology (QSP) model that looks at the mentioned che

243 ned in key organs and a quantitative systems pharmacology (QSP) model was established to simulate PK

244 vel results from a complex interplay between pharmacology, regulation, subcellular localization, and

245 pecific amide residues of 2 for the distinct pharmacology relative to 1 and 3.

246 hannel assembly, gating, ion selectivity and pharmacology remain obscure.

247 n which to integrate previous physiology and pharmacology research and a rational basis for the devel

248 The current state of pharmacology research for CUD highlights the need to con

249 oint, we provide considerations for clinical pharmacology research to provide safe and effective trea

250 research settings for cancer prevention and pharmacology research.

251 s, governmental and toxicological databases, pharmacology resources, and bioassay repositories.

252 Optogenetic approaches combined with in vivo pharmacology reveal that these BLA-PFC-PAG connections a

253 In vitro pharmacology revealed that the ArPPLNP2-derived neuropep

254 fety considerations and additional secondary pharmacology screens drove optimization that delivered t

255 The addition of secondary pharmacology screens to refinement delivered lead compou

256 The TB Pharmacology section within the new GTN aims to detect a

257 , an assertion consistent with the analgesic pharmacology seen in this animal.

258 This coupled with electrophysiology and pharmacology showed that HCN1 channels restrict the rate

259 and could potentially suggest novel systems pharmacology strategies.

260 The detailed preclinical ADME and pharmacology studies of 63 support further development o

261 formulas can be proposed for future clinical pharmacology studies that show drug-induced heart rate c

262 It is essential for onco-pharmacology studies to precisely document the hypoxic s

263 This systems pharmacology study investigated P-gp activity in mice ac

264 eriment 1, a double-blind placebo-controlled pharmacology study, we measured how flanking distractors

265 Recent advancements in predictive pharmacology, such as the application of multitask and t

266 Other SLC transporters have emerged as pharmacology targets.

267 as enable drug discovery for transporters as pharmacology targets.

268 lanocortin signaling motif, which results in pharmacology that is first-in-class for the central mela

269 most recent basic biology, biochemistry, and pharmacology that serve as a foundation for more than 50

270 This brief review covers concepts in opioid pharmacology that were promoted during the period leadin

271 spite its importance in human physiology and pharmacology, the molecular basis of hENT1-mediated aden

272 Phage pharmacology, therapeutic efficacy, and resistance were

273 drugs or mutations in fields as medicine and pharmacology, therefore paving the way for the developme

274 and Experimental Therapeutics, and Molecular Pharmacology These revisions relate to data analysis (in

275 we highlight progress in understanding their pharmacology through the lens of structural biology and

276 peptides have severely hampered their use in pharmacology, thus prompting the design of new peptidomi

277 preclinical studies support using resolution pharmacology to convert the pro-inflammatory condition i

278 mbined optogenetics with calcium imaging and pharmacology to demonstrate that stimulation of NPVF cel

279 We applied systems pharmacology to identify and validate specific regulator

280 ogy, and in vivo optogenetics with localized pharmacology to identify neural substrates downstream of

281 We used genetic manipulations and pharmacology to inhibit MNK-eIF4E activity in animals wi

282 Here, we used constellation pharmacology to investigate rat dorsal root ganglion neu

283 l and mechanistic approach used in classical pharmacology to kinetic signaling data, facilitating opt

284 tend and test theoretical models of receptor pharmacology to more accurately describe and predict lig

285 inity purification sequencing and behavioral pharmacology to test the hypothesis that in Nav1.8-posit

286 This versatile precision pharmacology tool enhances investigation of local kinase

287 We utilize a new precision pharmacology tool, Local Kinase Inhibition, to inhibit t

288 It then discusses the pharmacology underlying the therapeutic and main adverse

289 In molecular and cellular pharmacology, understanding physiopathological associati

290 NTS: Randomized clinical trial at a clinical pharmacology unit (West Bend, Wisconsin) was conducted i

291 In this study conducted in a clinical pharmacology unit and examining sunscreen application am

292 inical trial conducted at a phase 1 clinical pharmacology unit in the United States and enrolling 24

293 Thus, 2-photon pharmacology using alloswitch allows investigating mGlu(

294 creen of small molecule compounds with known pharmacology using human myeloid cells, searching for th

295 lecular properties ranging from materials to pharmacology using light as an external trigger with hig

296 Together, these observations suggest KOR pharmacology varies based on the specific Galpha subunit

297 For behavioral pharmacology, we computed medication effects on alcohol-

298 tein coupled receptor structural biology and pharmacology: What chemical features dictate G protein o

299 nonsteroidal anti-inflammatory drug (NSAID) pharmacology with acid-sensing ion channels (ASICs), a s

300 ll models may not be reliable for predicting pharmacology with this protein.