ライフサイエンスコーパス: phenocopy

1 ause a phenotype resembling HCM (genocopy or phenocopy).

2 Thus, the overexpression of fcrX(+) phenocopied a fur mutant and may prove a generally usefu

3 racellular concentrations of this amino acid phenocopied a TbAAT2-4 genetic defect.

4 One way to design a drug is to attempt to phenocopy a genetic variant that is known to have the de

5 are sufficient to reduce gene expression and phenocopy a peripheral neuropathy caused by the HNPP-ass

6 sites in human embryonic stem cells, thereby phenocopying a more primitive cellular state.

7 We report that Ada(-/-) mice, phenocopying ADA-deficient humans, displayed SNHL.

8 f the secreted neurotrophin Spatzle 3 (Spz3) phenocopied alphaSNAP phenotypes, which included loss of

9 iation, enhanced mesenchymal transition, and phenocopying alterations that occur with high D-2HG leve

10 n functional experiments, LDH overexpression phenocopied AMPKalpha1(-/-) phenotype, that is shifted M

11 The DeltamroQ mutant phenocopies an S. aureus mutant containing a deletion of

12 Using genetic, molecular, and phenocopy and biochemical evidence, we have firmly estab

13 110alpha, beta, and delta, yet APDS2 largely phenocopies APDS1 without dramatic effects outside the i

14 Knockout of p53 largely phenocopies ARF loss, with increased protein synthesis a

15 test human craniocardiac candidate genes for phenocopy as a critical first step towards understanding

16 isease and severe ocular surface damage that phenocopied aspects of human pseudohypoaldosteronism-1 M

17 This phenocopies aspects of Lamp1/2 knockdowns and Dppa3 (KO)

18 gger of GPX4-restricted mucosal inflammation phenocopying aspects of human CD.

19 involving ABL1, ABL2, CSF1R, and PDGFRB that phenocopy BCR-ABL1 and alterations of CRLF2, JAK2, and E

20 Depletion of the exocyst complex phenocopied BLOC-2 depletion, resulting in immature WPBs

21 helial- and lymphatic-specific Hk2 knockouts phenocopy blood and/or lymphatic vascular defects seen i

22 rotein-coupled receptor for 12-HETE, largely phenocopies both the depletion and the inhibition of 12-

23 embryos with severe mesodermal defects that phenocopy brachyury null mutants.

24 uced phagocytosis capability and this can be phenocopied by adding monomeric alphaS to the cell cultu

25 These cold-induced effects in obese VAT are phenocopied by an administration of the FGF21-mimetic an

26 Effects of PTEN deficiency were phenocopied by beta-Arrestin1 KD or inhibition of beta-A

27 This effect was phenocopied by dual genetic inactivation of KDM6A/B usin

28 The effects of exercise were phenocopied by galanin overexpression in noradrenergic n

29 This effect was phenocopied by genetically inhibiting copper import in t

30 Retinal vascularization defects are phenocopied by inducible inactivation of the gene for al

31 This effect was phenocopied by inhibition of the kinase mTOR, by inducti

32 nic defects caused by pericyte depletion are phenocopied by intraocular injection of VEGF-A or pericy

33 flux from PPIP5K KO cells was quantitatively phenocopied by KO of XPR1 itself.

34 iameters of its site of synthesis and can be phenocopied by manipulating non-diffusible Pent targets

35 tive control MS432N (24), and its effect was phenocopied by MEK1/2 knockdown.

36 y low appetite and extreme leanness; this is phenocopied by mice carrying similar mutations and can b

37 iding in this E/M hybrid state and cannot be phenocopied by mixing two cell populations that reside s

38 and alterations in place preference, are not phenocopied by MK-801, suggesting a developmental origin

39 hium-induced behavioral changes in mice were phenocopied by modulation of the circadian system with d

40 n single-SF mechanics may be correspondingly phenocopied by overexpression of mono- and diphosphomime

41 Strikingly, it is phenocopied by pre-colonization of germ-free mice before

42 ges, which depend on RhoA activation and are phenocopied by Rap1 inhibition, permit subsequent entosi

43 Surprisingly, this is not phenocopied by rapid rapamycin-dependent relocalization

44 These behavioral phenotypes could be phenocopied by selective inactivation of synaptic transm

45 ave demonstrated that IL-22 signaling can be phenocopied by synthetic cytokine receptors, identified

46 utes it for lysosomal degradation, an effect phenocopied by TMED9 deletion.

47 Furthermore, rover foraging scores can be phenocopied by transgenically reducing pr4 expression in

48 Genetic disruption of DCAF15 was phenocopied by treatment with indisulam, an anticancer d

49 l and molecular synaptogenic defects are all phenocopied by Wg overexpression, suggesting that Notum

50 ysiology of T. gondii tachyzoites appears to phenocopy cancer cells, which holds promise for developi

51 prompts a collapse of global elongation that phenocopies CDK9 inhibition.

52 saturation following exposure to palmitate, phenocopying cells with perturbed SCD1 activity.

53 mpaired Pseudomonas aeruginosa phagocytosis, phenocopying CF MPhis.

54 However, deletion of the CTD does not phenocopy clsy or shh1 mutants, consistent with the CTD

55 s, with higher order cik mutant combinations phenocopying clv2/crn flower outgrowth defects.

56 rescued stress vulnerability in FTD neurons, phenocopying CRISPR-mediated MAPT-knockout.

57 Phenocopying Ctbp2 deletion, both Ctbp inhibitors caused

58 evolved a small tiller angle, allowing it to phenocopy cultivated rice at the seedling stage.

59 Finally, inhibition of ADAM10 phenocopies Cx3cr1(-/-) and Cx3cl1(-/-) synapse eliminat

60 acellular domains of cytokine receptors that phenocopy cytokine signaling induced by nonphysiological

61 letion caused a filamentation phenotype that phenocopied defects in this process.

62 A deficiency of S100b phenocopies deficiency of calsyntenin 3beta, and forced

63 mer and its associated sorting nexin, SNX27, phenocopied each other in matrix degradation via selecti

64 DeltakhpA and DeltakhpB mutants phenocopy each other exactly, consistent with a direct i

65 EBV EBNA3A phenocopies EBF1 activities in LMP1-expressing B cells,

66 Pharmacological inhibition of GCN2 phenocopies eIF2B5 depletion and has therapeutic efficac

67 on or overexpression respectively blocked or phenocopied enriched conditioning-dependent axon regener

68 mals in ryr1b, fras1, tnnt2a, edar and hmcn1 phenocopied established mutants.

69 Although it is impossible to phenocopy every symptom of human depression in rodents,

70 Two separate exoc5 mutant zebrafish lines phenocopied exoc5 morphants and, strikingly, exhibited a

71 f SpGAI expression in females to male levels phenocopied exogenous GA application with respect to flo

72 a generic inhibitor of HMT activity, DzNep, phenocopies expression of an inducible dominant negative

73 ition to developing a preclinical model that phenocopies exudative AMD, our studies revealed that the

74 es genes such as Plag1, whose overexpression phenocopies Ezh2 loss to accelerate AML induction in mou

75 ype (WT) mice co-housed with Fam3D(-/-) mice phenocopy Fam3D-deficiency showing increased sensitivity

76 An interaction-defective mutant, dbf4DeltaC, phenocopies fkh alleles in terms of origin firing.

77 mission block show that elevated PN activity phenocopies FMRP-null defects, whereas PN silencing caus

78 This division mode dependence is phenocopied following conditional deletion of HR gene Br

79 s, but it is unknown whether these mutations phenocopy gain-of-function mutations in the CTNNB1 gene

80 omozygosity for the Gdf11(WE) allele did not phenocopy Gdf11 knockout skeletal phenotypes.

81 nal pharmacological inhibition approach that phenocopies gene silencing.

82 ly reduces adipose tissue in wild-type mice, phenocopying genetic haploinsufficiency for the Fsh rece

83 e against S. Enteritidis in neonatal chicks, phenocopying germ-free mice associated with adult chicke

84 aturated fat-induced steatosis and fibrosis, phenocopying germline L-Fabp(-/-) mice.

85 CTTN silencing in human MKs phenocopies HDAC6 inactivation and knockdown leads to a

86 lings, but not conventional laboratory mice, phenocopied human immune responses in two preclinical st

87 hyperoxia develop hypoalveolarization, which phenocopies human BPD, and Nrf2 deficiency worsens it.

88 escence, resulting in tumors that accurately phenocopy human ANNUBP and progress to MPNST with high p

89 of JH4 to LmnaG609G/G609G-mutant mice, which phenocopy human HGPS, resulted in a marked improvement o

90 c-outlet obstruction and cloacal dilatation, phenocopying human congenital LUTO.

91 ll membrane-bound IL-6R into sIL-6R proteins phenocopying hyperactivation of ADAM-mediated shedding o

92 ial enlargement, fibrosis, and inflammation, phenocopying ibrutinib treatment.

93 f WT recipients of Id cDKO bone marrow cells phenocopied Id cDKO cardiac fibrosis 4 months post-trans

94 These mice phenocopied Ifnlr1-null animals, exhibiting increased in

95 e from IL-6-triggered inflammation and fully phenocopied IL-6Ralpha-deficient mice without IL-6 overe

96 on of neutrophils or Padi4-dependent NETosis phenocopies IL17 neutralization.

97 Moreover, because these mice do not phenocopy Il17f(-/-) mice, they may provide a valuable t

98 ks GFI1B-mediated erythroid differentiation, phenocopying impaired differentiation brought on by LSD1

99 e PPHD knockout on antibiotic resistance was phenocopied in bacteria exposed to atmospheric hypoxia.

100 This lack of response could be phenocopied in fibroblasts with the expression of a repr

101 These findings were phenocopied in healthy human ECs after SHIP2 silencing.

102 cement at the virus entry step, a phenomenon phenocopied in HIV-1 infections of IFN-alpha-treated pri

103 This effect was phenocopied in mice carrying a conditional deletion of P

104 duce fewer and larger proplatelets, which is phenocopied in mouse Myh9-RD models.

105 use model is confounded by lipodystrophy not phenocopied in people.

106 The effects of antibiotics were phenocopied in Stat1-deficient mice, with no additional

107 ing of embryonic and adult zebrafish that is phenocopied in zebrafish deficient in Ltk.

108 Expression of Aurora B S227A phenocopies inhibition of PKCepsilon in by-passing the d

109 c, and NK cells with c-Myc haploinsufficency phenocopied IRE1alpha-XBP1 deficiency.

110 e further show that genetic UbcH7 deficiency phenocopies ITCH phosphorylation in regulating RIPK2 ubi

111 We found that NANOS2 knockout pigs phenocopy knockout mice with male specific germline abla

112 ite, rationalizing why mutation of this site phenocopies known hotspot alterations.

113 al Mycobacterium tuberculosis (Mtb) isolates phenocopy lepA deletion to varying degrees.

114 um as well as to other chronomodulators that phenocopy lithium.

115 Treatment with antioxidant N-acetyl cysteine phenocopied loss of Klf9 including suppression of melano

116 Knockdown of phb-2 partially phenocopied loss of mec-2 in touch neurons of the nemato

117 Silencing of TEAD phenocopies loss of YAP1, implicating transcriptional tr

118 vivo, and mutations in the Cas10 Palm domain phenocopy loss of Csm6.

119 r, and that deficiencies in ADPr degradation phenocopy loss of pADPr synthesis, suggest that ADPr deg

120 with delayed Nanog promoter methylation and phenocopying loss of Eprn or Lin28a.

121 odelling and DSB-repair via HRR; effectively phenocopying loss of TIP60.

122 Furthermore, prolonged RA exposure phenocopies LSD1 inhibition, suggesting that LSD1 regula

123 l maturation characteristics in macrophages, phenocopying macrophage activation, and exhibited potent

124 ial striatum of adult mice was sufficient to phenocopy maladaptive eating behaviors of VAChTcKO mice.

125 ltured in conventional serum plus LIF medium phenocopy male ES cells cultured in 2i/L.

126 y responses.(,) Deletion of miR-146a in mice phenocopies many aspects of age-dependent inflammation,(

127 UFS4), a subunit of mitochondrial complex I, phenocopies many traits of the human disease Leigh syndr

128 fest in hyperkinetic movement disorders that phenocopy many features of early Huntington's disease, c

129 epressive-like pathology in ELS females that phenocopy many of the behavioral characteristics of depr

130 Knockout of beta2 integrins in HSPCs phenocopies mDia2 deficient mice.

131 In mouse embryonic stem cells, phenocopying METTL14 knockdown, H3K36me3 depletion also

132 uding tumour suppressors ARHGDIA and TAGLN2, phenocopied miR effects, demonstrating physiological rel

133 Cs relative to normal ECs, and QKI silencing phenocopied miR-200b-mediated inhibition of sprouting.

134 lycan Adam10 mutant or of the N-glycoenzymes phenocopied miR-223 mutant defects.

135 sirt2 RNAi also phenocopies mir-92a overexpression.

136 embryonic lethal and die around E10.5, which phenocopies Mll4 knockout mice.

137 lly, we provide evidence of human cells that phenocopy murine CD122+Macs in secretory phase endometri

138 Finally, C2/C10 DKO mice partially phenocopied mutant C10 KI mice with the development of c

139 4-chloro-HIPP biochemically and biologically phenocopied mutational inactivation of CtBP2 W324.

140 ter and Drosophila simulans are sterile, and phenocopy mutations in the PIWI interacting RNA (piRNA)

141 -4 contribute to polarized root hair growth, phenocopying myosins, whereas MadA1-4 are redundant for

142 Here, IL-22 SyCyRs phenocopied native IL-22 signal transduction, indicated

143 o mice bearing experimental liver metastases phenocopied neutrophil depletion by reducing liver metas

144 al amino acid in NLGN4X, and these mutations phenocopy NLGN4Y.

145 This result phenocopies NLRC3-deficient macrophages and fibroblasts

146 Accordingly, enforced Pum2 expression fully phenocopies Norad deletion, resulting in rapid-onset agi

147 ere, we report on a bile duct-on-a-chip that phenocopies not only the tubular architecture of the bil

148 The mir-279/996 defect phenocopies Notch loss of function during the sheath-neu

149 Ectopically expressed Ank4 blocks ERAD to phenocopy O. tsutsugamushi infection.

150 or cause renal diseases that may manifest as phenocopies of CAKUT.

151 Because severe G6PD deficiency can be a phenocopy of chronic granulomatous disease with regard t

152 giograms suggest that foveal hypoplasia is a phenocopy of grade 1 NCMD, torpedo maculopathy is a phen

153 py of grade 1 NCMD, torpedo maculopathy is a phenocopy of grade 2 NCMD, and in this single family, co

154 single family, congenital toxoplasmosis is a phenocopy of grade 3 NCMD.

155 A B cell autoimmune phenocopy of inborn errors of type I IFN immunity accoun

156 8Q represents a novel molecular and clinical phenocopy of inherited USP18 deficiency, which, together

157 rgan integration of hormonal signalling as a phenocopy of menstrual cycle and pregnancy-like endocrin

158 stress-induced relapse to alcohol seeking, a phenocopy of postdependent rats.

159 PRKAG2 syndrome is a rare autosomal dominant phenocopy of sarcomeric hypertrophic cardiomyopathy (HCM

160 vitro, and able to reconstitute an anatomic phenocopy of the native thymus, when combined with thymi

161 Ablation of the PIP4Ks generates a phenocopy of the pharmacological effects of PIP4K inhibi

162 BA application to plants generated a partial phenocopy of the water-productivity trait.

163 CIZ1 or deletion of Repeat E in female cells phenocopies one another in causing Xist RNA to delocaliz

164 Overexpression of Drp1 K38A or S637A mutant phenocopies or rescues mTOR activation and senescence in

165 pletely abolished spontaneous remyelination, phenocopying OSMRbeta KO mice.

166 Inhibition of HBO1 phenocopied our genetic data and showed efficacy in a br

167 nt immunity and promotes Las multiplication, phenocopying overexpression of SDE15.

168 plasmic reticulum (ER) contact sites (MERCs) phenocopies OxPHOS inhibition.

169 ous or hematopoietic restricted Osm deletion phenocopied p66Shc deletion in preventing diabetes-assoc

170 f Ewing sarcoma cells and induced apoptosis, phenocopying pharmacologic inhibition of LDH.

171 n Hsp70 inhibitor and knockdown of PfHsp70-1 phenocopy PI(3)P-deficient parasites under heat shock.

172 eavage by caspase 7; knock-down of caspase 7 phenocopies PKCepsilon loss, in a manner rescued by ecto

173 An eNOS inhibitor phenocopied PLD2 loss and had no further effect on PLD2

174 n the quintuple mutant (mkk1/2/3RNAi/mkk7/9) phenocopied pollination defects observed in the mpk4RNAi

175 a (ENU)-induced mutation (explorer) in Gpr89 phenocopied Rabl3 (xm).

176 e, a small-molecule activator of PP2A (SMAP) phenocopies restoration of wild-type PPP2R1A to suppress

177 ed, the biliatresone effect on spheroids was phenocopied, resulting in lumen obstruction.

178 function of a cargo adaptor, Jip3, partially phenocopied Ret axonal defects, led to accumulation of a

179 bation resulted in decreased Rps2 levels and phenocopied Rps2 depletion.

180 rom either ooDSGCs or interneurons partially phenocopies Satb1 mutants, demonstrating that Satb1-depe

181 fects on craniofacial and brain development, phenocopying Shh mutations.

182 Knockdown of Arp-1 phenocopies Shot loss universally, whereas chemical disr

183 well as RAP1A but not RAB7A, a pattern that phenocopied silencing FNTA, the prenyltransferase alpha

184 he SIRPalpha ligand CD47 (CD47(-/-)), do not phenocopy SIRPalpha deficiency and fail to fully develop

185 nd craniofacial mesenchyme ( Prx1-cKO) would phenocopy skeletal and dental manifestations of late-ons

186 l1a1a function in zebrafish (Danio rerio) to phenocopy skeletal reduction in Antarctic notothenioids.

187 2b), and loss of Cers2b in sphk2(MZ) embryos phenocopies sphingosine toxicity.

188 d Rab8 as ICMT substrates that when silenced phenocopy ste14 deficiency.

189 ific tau phosphorylation is neuroprotective, phenocopying tau ablation, thus highlighting the complex

190 transcription factor of which polymorphisms phenocopy thalidomide-induced limb defects in humans.

191 duced by hotspot mutations or driving "dual" phenocopies that mimicked 2 co-occurring hotspot mutatio

192 nes act upstream of Isc1, and their deletion phenocopies that of ISC1 Reciprocally, ISC1 deletion mut

193 -18R signaling in T cells, but not of IL-1R, phenocopied the absence of the MyD88 pathway, indicating

194 metic mutants were electrically inactive and phenocopied the almt4 mutants.

195 nsible for generating the respiratory rhythm-phenocopied the breathing deficits observed after RTN de

196 ng site in the NLRP3 3' untranslated region, phenocopied the characteristics of miR-223(-/y) mice.

197 Silencing MYC expression phenocopied the CSC depletion effects of C1572 and induc

198 unx1, a cellular binding partner of CBFbeta, phenocopied the D/N Vif phenotype by sequestering endoge

199 TCR stimulation in the presence of monensin phenocopied the defects in Napa(hyh/hyh) signaling and T

200 he introduction of the RL13 mutant partially phenocopied the DIDS resistance phenotype.

201 ntrols ROS formation independently of CoQ10, phenocopied the effect of Coq2-RNAi.

202 d overexpression, whereas silencing of EphA4 phenocopied the effect of miR-519d.

203 and Epac pathways by specific cAMP analogues phenocopied the effects of adenosine signaling on murine

204 of these socially active neuronal ensembles phenocopied the effects of cagemate presence in male and

205 MHCII deficiency phenocopied the effects of CREBBP loss in spontaneous an

206 ac1 with an Epac specific inhibitor, ESI-09, phenocopied the effects of Epac1 null by suppressing neo

207 Individual cytokines in ICM phenocopied the effects of ICM on NF-kappaB activation a

208 ECT2 siRNA phenocopied the effects of miR-1300, and ECT2 overexpres

209 BD1 inhibitors phenocopied the effects of pan-BET inhibitors in cancer

210 ted class I sirtuin inhibitor, YC8-02, which phenocopied the effects of SIRT3 depletion and killed DL

211 RUSC2 knockdown phenocopied the EHD1 depletion effects.

212 only the combined loss of PLXNA1 and PLXNA3 phenocopied the full spectrum of nasal axon and GnRH neu

213 f ATP synthesis by oxidative phosphorylation phenocopied the growth defect observed in the RsbU null

214 IC, but not by MDFI, and HIC1 overexpression phenocopied the growth suppressive effects of MDFIC in H

215 Acute depletion of Pim1 phenocopied the high mtDNA levels observed in Deltamrx6

216 The thyroid tumors closely phenocopied the histological features of human RAS-drive

217 were recruited to cccDNA minichromosomes and phenocopied the IFN-alpha-induced posttranslational modi

218 ngly, JG-98, an advanced MKT-077 derivative, phenocopied the lethal effects of mortalin depletion in

219 -17~92:Bim interactions early in development phenocopied the lethal lung phenotype of miR-17~92 ablat

220 concurrent knockdown of CD44v Silencing p53 phenocopied the loss of ZMAT3 with respect to CD44 alter

221 tic ablation of C2cd4a in beta cells of mice phenocopied the metabolic abnormalities of human carrier

222 CD68.hMcl-1 AMs phenocopied the microbicidal defect because transgenic m

223 ric protein (GalphaS) into wild-type oocytes phenocopied the MIHR mutants.

224 The min7/ben1 mutant phenocopied the mild root developmental defects and latr

225 Germ line Notch2(COIN) inversion phenocopied the Notch2HCS mutant, validating the model.

226 on of PCM1, and knockdown of endogenous PCM1 phenocopied the observed effects of miR-128 overexpressi

227 Pharmacological inhibition of VEGF signaling phenocopied the pax2a(-/-) vasculature, F-actin and BM d

228 ulation of Bsnd in the parental mouse strain phenocopied the severe cystic kidney phenotype.

229 r show that applying methyl jasmonate (MeJA) phenocopied the stem elongation of Zeo1.b, and that Zeo1

230 dental mesenchymal-specific deletion of Evc2 phenocopied the tooth abnormalities in Evc2 mutants.

231 on (increased V (max) with unchanged K (m)), phenocopies the ability of protein kinase A (PKA) to act

232 recruit Frizzled and LRP5/6 in a manner that phenocopies the activities of Wnts both in vitro and in

233 We show that the myelotomy model best phenocopies the anatomy, etiopathophysiology and symptom

234 Once activated, this MX1 construct phenocopies the antiviral and NP binding activity of wil

235 tal muscle and muscle-specific BDNF knockout phenocopies the beta-cell TrkB.T1 deletion metabolic imp

236 Remarkably, this mouse phenocopies the blood-lymphatic mixing and lethality of

237 Endocardial deletion of Efnb2 phenocopies the coronary arterial defects of Notch mutan

238 ibition of the ERK and mTOR cascades largely phenocopies the defect observed in the absence of Shp-2.

239 f KLK5, a known target of PRSS3/mesotrypsin, phenocopies the effect of PRSS3/mesotrypsin knockdown, a

240 e report a dibenzothiazepinone compound that phenocopies the effects of a Bdf1 BD-inactivating mutati

241 nockdown in these neurons of wild-type flies phenocopies the food overconsumption phenotype of piezo-

242 Conversely, knockdown of for in pr1 cells phenocopies the for null mutant.

243 Overexpression of GA2ox2 in the RM phenocopies the hdt1,2i phenotype.

244 n (KI) mice expressing an Itgb3 variant that phenocopies the human Pro33 variant to elucidate the con

245 ontrolled amino acid transporter effectively phenocopies the impact of Myc deletion.

246 ein NEURL4, and knockdown of HERC2 or NEURL4 phenocopies the inhibition of RNF8/UBC13 signaling on sy

247 her demonstrate that knockdown of keratin 18 phenocopies the loss of Krtap5-5, suggesting that Krtap5

248 RF5 expression in the eosinophil compartment phenocopies the loss of the entire lineage.

249 Forced-expression of MICU1 in normal cells phenocopies the metabolic aberrations of malignant cells

250 enotypic target whose derepression partially phenocopies the mir-35-42 mutant phenotype by inducing e

251 d a kinase dead allele of Fgfr2 that broadly phenocopies the null mutant.

252 the reticular structure of PNNs is lost and phenocopies the PNN structural abnormalities observed in

253 Inhibition of miR-139-5p in vivo partially phenocopies the retinal vascular defects of APLN/APLNR d

254 However, loss of Ryk phenocopies the Wnt5a (-/-) phenotype, perturbing post-m

255 ible nonobese diabetic (NOD) mouse model, we phenocopy the diabetes progression induced by programmed

256 and that Arabidopsis mtn1 mtn2 mutant plants phenocopy the effect of HopAF1.

257 , we observed that PORCN inhibition does not phenocopy the effects of WNT4 knockdown in WNT4-dependen

258 tion, such as etoposide and ICRF-193, do not phenocopy the effects on chromosome structure of TOP2A d

259 s, as beta cell-specific Galpha(z)-null mice phenocopy the full-body KOs.

260 ogenitors while mutant ugdh zebrafish do not phenocopy the human disease.

261 d induction of EMT by ZEB1 was sufficient to phenocopy the increase in fluvastatin sensitivity; knock

262 ls, or TPCs, a cancer cell able to propagate/phenocopy the parental tumor and recapitulate tumor hete

263 show that mutant iPSC-derived cardiomyocytes phenocopy the pathology seen in hearts of patients with

264 NFLP was also shown to phenocopy the PYCR1 knockdown in MCF10A H-RAS(V12) breas

265 Remarkably, these optix knockouts phenocopy the recurring "black and blue" wing pattern ar

266 all molecule inhibitors of GSK3 to partially phenocopy the regulatory effects of stimulation in the p

267 ve PTK2 degradation, these compounds did not phenocopy the reported antiproliferative effects of PTK2

268 While loss-of-function lines phenocopy the stunted root hair phenotype of other Atget

269 Rac2(+/E62K) mice phenocopy the T- and B-cell lymphopenia, increased neutr

270 ual ABA receptors might offer an approach to phenocopy the water-productivity trait of the high WUE l

271 terations, including partially or completely phenocopying the alterations in exon and splice site rec

272 auses delayed onset of cell differentiation, phenocopying the effects of IYO knockdown at the transcr

273 lation results in failure of this septation, phenocopying the human heart defect persistent truncus a

274 f CrzR in PTTH neurons increased pupal size, phenocopying the inhibition of Crz neuronal activity.

275 increases LHLK neuron activity in fed flies, phenocopying the starvation state.

276 integrin-alpha subunits inhibition of which phenocopied these effects, suggesting that a specific re

277 emonstrated that sequestering CHD4 from NuRD phenocopied these mutations.

278 erin, and blocking miR-126 activity in HLECs phenocopies these changes in expression.

279 enotypes, while acute induction of apoptosis phenocopies these defects and reveals that phagocytosis

280 specimens, and that TGF-beta treatment would phenocopy these metabolic changes.

281 Inhibiting the alpha isoform of GSK3 phenocopied this effect, and pharmacologic GSK3alpha inh

282 Ablation of cGAS in hepatocytes only phenocopied this hepatoprotection, highlighting the crit

283 ible endothelial-specific caspase-9 deletion phenocopies this protection, with attenuated retinal ede

284 rophy and dystrophin-deficient mdx mice that phenocopy this disorder.

285 as-specific Hnf1a null mutant transcriptomes phenocopy those of Kdm6a mutations, and both defects syn

286 T mutations thus appear to underlie clinical phenocopies through impairment of the IL-6 and IL-11 res

287 rexpression, whereas String/Cdc25 expression phenocopies Tiggrin mutants.

288 sed proliferation and branching, but did not phenocopy transgenic expression of activated smoothened

289 ylglyoxal treatment of Drk1-expressing yeast phenocopied treatment with fludioxonil.

290 with mirn23a (-/-) BMDMs into wild-type mice phenocopied tumor growth in mirn23a (-/-) mice, supporti

291 Highly adapted herbivores can phenocopy two-component systems by stabilizing, sequeste

292 d gastric phenotype of Stat3(SA/SA) mice was phenocopied upon genetic ablation of signaling by the cy

293 nse to endothelial injury, a defect that was phenocopied using direct oral anticoagulants.

294 we demonstrate that zebrafish eif2b mutants phenocopy VWM, including impaired somatic growth, early

295 independent endocytosis in proximal tubules, phenocopying what has been reported for Dent disease cau

296 These results were phenocopied with a KDM3B CRISPR/Cas9 knockout.

297 s, syndromal non-podocyte-specific genes and phenocopies with other underlying genetic abnormalities

298 The double mutant badc1 badc2 phenocopied wri1-1 with respect to both reduction in roo

299 tion of xCT by low concentrations of erastin phenocopied xCT-KO and potentiated the cytotoxic effects

300 2-deletion blocked endothelial migration and phenocopied Yap/Taz-deficient mutants.