ライフサイエンスコーパス: phenotype

1 early development of the preterm behavioral phenotype.

2 ich familial risk is translated into the SCZ phenotype.

3 nd supports the acquirement of a mesenchymal phenotype.

4 both WT and DKO ERCs confirmed their DR-cell phenotype.

5 iary structure and function towards a normal phenotype.

6 e defects that are concordant with the human phenotype.

7 signaling pathway in the mTORC1-driven lung phenotype.

8 d reactivation into a pathogenic Th17/GM-CSF phenotype.

9 exhibit the HNF1A/KDM6A-deficient molecular phenotype.

10 g rare stochastic transitions of single-cell phenotype.

11 portant role in the induction of asthma-like phenotype.

12 ulating vascular tone and smooth-muscle cell phenotype.

13 lele of Cebpb prevented the pro-inflammatory phenotype.

14 s is responsible for inducing the metastatic phenotype.

15 mber of genotypes that give rise to the same phenotype.

16 assified as having either a severe or a mild phenotype.

17 pic clustering, consistent with an activated phenotype.

18 on of macrophages to the anti-cancer M1-like phenotype.

19 r-specific antibodies (DSA) and histological phenotype.

20 tosol, which leads to a premature senescence phenotype.

21 YAP1 in maintenance of the adult epithelial phenotype.

22 ell or neuroendocrine prostate cancer (NEPC) phenotype.

23 enomas and that SCNAs correlate with adenoma phenotype.

24 nduces a hyperdistended/hypertrophic bladder phenotype.

25 s showed no discernible morphological growth phenotype.

26 cell responses that were biased toward a Th1 phenotype.

27 ts, in correlation with the stomatal opening phenotype.

28 nction, particularly in patients with type 2 phenotype.

29 en applying BOLT-LMM to GWAS, GWAX and LT-FH phenotypes.

30 ivity drive the cell to certain outcomes and phenotypes.

31 les under certain experimental conditions or phenotypes.

32 could potentially explain breast cancer risk phenotypes.

33 neurodegeneration, dementia and other brain phenotypes.

34 FDA-approved drugs able to ameliorate these phenotypes.

35 he molecular landscape shaping these complex phenotypes.

36 f the redirected ligase do not explain these phenotypes.

37 esearch progress of physiologically relevant phenotypes.

38 salicylic acid- and EDS5-independent mutant phenotypes.

39 ular mechanisms of AF and cardiac conduction phenotypes.

40 on and splicing and promotes aggressive TNBC phenotypes.

41 transgenerational transmission of behavioral phenotypes.

42 g the same period to derive novel resilience phenotypes.

43 are incapable of detecting the proposed OAB phenotypes.

44 that are thought to account for the observed phenotypes.

45 opathological evaluation by clarifying tumor phenotypes.

46 ith mesenchymal state and embryonic cellular phenotypes.

47 s across thousands of clinical and molecular phenotypes.

48 ibutions to developmental processes and cell phenotypes.

49 ion of these elements to important bacterial phenotypes.

50 arly classify and characterize tumour-immune phenotypes.

51 a poor mechanistic understanding of studied phenotypes.

52 ship between genotypes and molecular imaging phenotypes.

53 with varying cognitive and neuropathological phenotypes.

54 differentiation of indolent from aggressive phenotypes.

55 tance, little is known about their infection phenotypes.

56 high-sucrose diet and profiled the metabolic phenotypes.

57 f entire compound libraries based on desired phenotypes.

58 njury, C4d positivity, and inflammatory cell phenotyping.

59 agocytic lymphohistiocytosis, is an emerging phenotype accompanying inborn errors of type I interfero

60 osertib have qualitatively indistinguishable phenotypes across multiple assays.

61 ically predicted effects on any of the other phenotypes after correcting for multiple testing.

62 8a (miR-18a) normalized AVM-BEC function and phenotype, although its mechanism remained unclear.

63 ation are critical for maintaining stem cell phenotype and cancer progression.

64 n human aortic SMCs suppressed the synthetic phenotype and downregulated Akt1/mTOR signaling.

65 Among them, the 2017 classification of phenotype and gingival recession successfully incorporat

66 Evaluating ATM phenotype and intracellular metabolism together may more

67 Surface phenotype and NanoString gene expression profiling indic

68 patient from Family 2 had a milder clinical phenotype and reduced exocytosis.

69 t of PIM loss or inhibition on mitochondrial phenotype and ROS.

70 's immune system toward an anti-inflammatory phenotype and therefore could provide unanticipated bene

71 association between LV noncompaction (LVNC) phenotype and vigorous physical activity (VPA) in the ge

72 The vaccine-induced T cells had a cytotoxic phenotype and were capable of trafficking to the tumor a

73 ells were found in all tissues, had a mature phenotype and, distinct from other NKT cells, expressed

74 e models of associations between factors and phenotypes and between factors and mortality.

75 es or strains give rise to different disease phenotypes and display strain-specific subsets of posttr

76 isease endpoints via intermediate proteomics phenotypes and identifies correlative networks that may

77 ulations that display mixed pancreatic islet phenotypes and immaturity.

78 environmental signals controlling hybrid EMT phenotypes and indicate that EMT involves multiple molec

79 s have been observed between neuroanatomical phenotypes and known genetic risk factors for schizophre

80 ts provided a more formal link between these phenotypes and lincNORS, further strengthening the case

81 We focus on phenotypes and mechanisms that underlie microvascular ag

82 ment formation but led to divergent adhesion phenotypes and NMIIA contractile activities depending on

83 the premature acquisition of age-associated phenotypes and pathologies in mammals.

84 ts to identify the diversity of MPS cellular phenotypes and the limited predictive value of surface m

85 nical properties underlying these two asthma phenotypes and the mechanisms explaining the paradox of

86 RK2 patients showed differences between both phenotypes and when compared with a sibling control in E

87 ained by the genetic overlap between the two phenotypes and, hence, shared biological mechanisms.

88 Additional phenotyping and in vitro studies enabled reclassificatio

89 man spectroscopy enables reliable neutrophil phenotyping and infection diagnosis in a label-free mann

90 ecture between depression defined by minimal phenotyping and strictly defined major depressive disord

91 lls are unable to differentiate into the Th2 phenotype, and acquire a Th17-like phenotype in response

92 ple molecular drivers of an otherwise common phenotype, and emphasize the potential for personalized

93 We compared the transcriptome, phenotype, and function of memory CD8(+) T cells, sharin

94 t radiation induces a glioma-initiating cell phenotype, and we have identified trifluoperazine (TFP)

95 dentification of novel mutations, genes, and phenotypes, and leading to improvements in both diagnost

96 These phenotypes are associated with increased acetylation of

97 chnical limitations as most synthetic lethal phenotypes are strongly modulated by changes in cellular

98 EMT and suggests that hybrid and mesenchymal phenotypes arise through independent molecular paths.

99 gene (Ace2(-/-) ), developed a cloudy cornea phenotype as they aged.

100 first is a patient reported suicide attempt phenotype asked as part of an online mental health surve

101 nctional shift in iMo toward an inflammatory phenotype associated with CAD progression is unknown.

102 The phenotype associated with CfrA overexpression is also ob

103 ransport in hERG1, leading to arrhythmogenic phenotypes associated with long-QT syndrome.

104 ts changed their apparent immunofluorescence phenotype between monotypic and polytypic, while all 3 p

105 e effect of natural selection on these blood phenotypes between populations.

106 onciling a previously identified conflicting phenotype but also revealed a potential intestinal resis

107 and have an immature and partially activated phenotype but do respond to ECTV.

108 This phenotype by AR2 is enhanced or suppressed by reducing o

109 build robust metagenomic predictors of host phenotype by comparing prediction performances and biolo

110 Rescue of unc-13/Munc13 mutant phenotypes by overexpressed open UNC-64/syntaxin suggest

111 his loss may be associated with the observed phenotype change but the mechanism remains unknown.

112 Gal-9(+) T cells exhibited the phenotype characteristics of effector T cells (CD45RA(+)

113 icient mice displayed a more unstable plaque phenotype characterized by an increased lipid and macrop

114 ss of KBTBD2 in all tissues causes the teeny phenotype, characterized by insulin resistance with late

115 The periodontal phenotype consists of the bone morphotype, the keratiniz

116 e models produced by the International Mouse Phenotyping Consortium.

117 transient NPC-like cellular and biochemical phenotypes, constitute plausible mechanisms that could b

118 mosome variants in males with neurocognitive phenotypes continues to present a challenge to clinical

119 TFP) as a compound that interferes with this phenotype conversion.

120 ous states to better understand the genotype-phenotype correlations and incomplete penetrance observe

121 onal heterogeneity seen in PDAC with similar phenotypes (cystic-solid).

122 logistic regression framework with a binary phenotype defined as event occurrence status during the

123 a unique localization pattern and knockdown phenotype, demonstrating centralspindlin-independent fun

124 rain-behavior associations in an extensively phenotyped developmental sample of 345 participants (312

125 were phenotypically heterogeneous, and their phenotype differed by rate of disease progression.

126 Their phenotype differs significantly from that of Johanson-Bl

127 A gradient in genotype and phenotype distribution exists across Europe, from classi

128 curate, clinically interpretable results for phenotype-driven genomic diagnostics.

129 nOVAmax induced a regulatory DC phenotype evidenced by a decrease of the activation mark

130 ectives: To determine whether such Crs-based phenotypes existed among patients with ARDS before the C

131 limited growth conditions, a high-throughput phenotyping facility was used to measure WUE(plant) in a

132 Two phenotypes fill into the second one: single-NSAID-induce

133 as low as <0.5%, were associated with milder phenotype for most of the evaluated clinical outcomes, i

134 lysis with extensive clinical and histologic phenotyping from 224 kidney transplant recipients betwee

135 nucleus of female mice undergoes a shift in phenotype, from GHRH to Kiss1, during pubertal transitio

136 We phenotype gene-deletion strains of fission yeast in 59,3

137 patients for many NDD risk genes, we present phenotype-genotype correlations for seven risk genes (CT

138 rovide our perspectives on how to bridge the phenotype-genotype gap.

139 The noninflammatory phenotype had the most favorable values for all measures

140 0.91; p = 0.006), but not among the other 2 phenotypes (Hp1 allele carriers) (n = 3,673; aHR: 0.95;

141 tissue and serum levels in several carefully phenotyped human cohorts.

142 ant and congruent features in predicting the phenotype identified by these four models are: polygenic

143 Loss of Myoc alone was sufficient to induce phenotypes identified in mouse models of cancer cachexia

144 it can be a herculean task to measure every phenotype in a combinatorial map.

145 rticular Aspergillus may impinge on clinical phenotype in asthma.

146 also induced an anergic T-bet(-)IFN-gamma(-) phenotype in CD8(+) T cells and was equally suppressive

147 red micro-architecture induced an epithelial phenotype in CRC cells while disordered ECM drove a mese

148 tuents tested but could not predict the AFFF phenotype in larval zebrafish.

149 y nervonic acid content alters the metabolic phenotype in mice fed a high fat diet.

150 lants, at levels reported to induce SCZ-like phenotype in normal rat strains, increased NDEL1 enzyme

151 tive agonist imiquimod (5.0 mg/kg) induces a phenotype in offspring characterized by reduced anxiety-

152 o the Th2 phenotype, and acquire a Th17-like phenotype in response to iTreg polarization.

153 d clinical parameters, mortality, and B cell phenotypes in blood and cerebrospinal fluid (CSF) by flo

154 is associated with clinical and inflammatory phenotypes in COPD.

155 n induces clonogenicity and dedifferentiated phenotypes in hepatoma cells.

156 Here, we demonstrated striatal phenotypes in heterozygous Disc1 mutant mice, which coul

157 Kenya, resulting in the risk of neurological phenotypes in older children.

158 e prevented abnormal molecular and cognitive phenotypes in rT1, demonstrating that NM hTau pathogenic

159 INA1 variants on lung function and emphysema phenotypes in subjects with significant tobacco smoke ex

160 study, we characterize the autoinflammatory phenotypes in the skin of both autoimmune polyendocrinop

161 se-free survival and promotion of aggressive phenotypes in vitro and in vivo.

162 e PSC-derived cardiomyocytes with adult-like phenotypes in vitro.

163 gulation is associated with numerous disease phenotypes including cancer.

164 The phenotype (including histopathology and serological stud

165 itulated the prebiotic-deprived hypertensive phenotype, including cardiac manifestations.

166 to maintain the signature TCR.Vgamma7(+) IEL phenotype, including specific responsiveness to Btnl pro

167 equences of EAE that may contribute to these phenotypes, including a reduction in adult locomotor act

168 f KCS1 in akr2a mutants rescued akr2a mutant phenotypes, including chilling sensitivity and a decreas

169 al IL-17-MALT-1 signaling regulates multiple phenotypes, including escape behavior, associative learn

170 and ACC2 iKO mice exhibiting a similar obese phenotype, increasing FAO oxidation by deletion of ACC2

171 Conclusions: Twelve genes showed diverse phenotypes indicating differential roles in insulin sens

172 cies of oral streptococci can antagonize the phenotypes induced by P. gingivalis, indicating function

173 y, these findings suggest that ABO expresser phenotype influences primary hemostasis though several d

174 The papaya diminutive phenotype is caused by an alteration in gene function ra

175 cadian mechanisms in the underlying fibrotic phenotype is not understood.

176 The physiological relevance of this phenotype is supported by decreased available dopamine D

177 within humans, our ability to link genes to phenotypes is based upon a handful of model microorganis

178 growth, six of them were further studied by phenotyping knock-out mutant plants.

179 Of 136 patients with phenotype L, 58 (43%) had a Pa(O(2))/Fi(O(2)) < 150.

180 nd their association with incident HF and HF phenotype (left ventricular [LV] ejection fraction [LVEF

181 tion requires detailed knowledge of genotype-phenotype maps; however, it can be a herculean task to m

182 models have close prediction results for the phenotype measured in Area Under the Curve: random fores

183 assessments to develop a novel computational phenotyping method that groups brain regions from MRI an

184 ascular risk for patients with different ACS phenotypes.Methods: Post hoc analysis of the ISAACC (Con

185 Probabilistic phenotype metrics offer the following three benefits.

186 ed DNA methylation age and neurodegenerative phenotypes might represent false positives resulting fro

187 y approaches in defining a clear genotype to phenotype model.

188 rt disease among participants with the Hp2-2 phenotype (n = 2,133; aHR: 0.71; 95% CI: 0.55 to 0.91; p

189 and Crs was characterized as a distinct ARDS phenotype.Objectives: To determine whether such Crs-base

190 ces methodological heterogeneity in defining phenotype, obscuring biological heterogeneity in researc

191 tribute to the premature immunological aging phenotype observed in these patients.

192 ability changes that cause dramatic cellular phenotypes observed at nonpermissive temperatures.

193 topography-dependent diversity in fibroblast phenotypes observed here.

194 ent uptake patterns resembling cancer-immune phenotypes observed in the clinic.

195 profiling successfully predict the bipotent phenotype of a previously uncharacterized population of

196 Our results demonstrate an unexpected mixed phenotype of apoB-reactive autoimmune T cells in atheros

197 We report the spectrum and associated phenotype of CEP290 mutations in the largest German coho

198 mechanisms underlying the observed metabolic phenotype of EC-AGO1-KO.

199 s study were to determine the prevalence and phenotype of FGR in women with AMSB and test the predict

200 effects-when parental environments alter the phenotype of future generations-can influence how organi

201 engraftment and maintenance of the cellular phenotype of injected tissue-resident macrophages.

202 d kisspeptin, Kiss1 (Kiss1-/-) replicate the phenotype of isolated hypogonadotropic hypogonadism (IHH

203 Thus, TLQP21 can modulate the functional phenotype of microglia, which may have an impact on thei

204 The phenotype of naa50-2 was rescued by the expression of Hs

205 se pancreatic cancer cells can influence the phenotype of non-neoplastic cells in the tumor microenvi

206 lossoptosis, and cleft palate, mimicking the phenotype of Pierre Robin sequence.

207 levels of uncleaved C99 in the ER, an early phenotype of the disease, upregulates the formation of t

208 Moreover, based on the enhanced memory phenotype of Tiam1 KO mice, Tiam1 may be a potential tar

209 Moreover, the phenotype of UNC93B1-defective phagocytes could be recap

210 ified 611 loci associated with time-to-event phenotypes of 12 common diseases, of which 38 loci would

211 mutants partially suppress photomorphogenic phenotypes of both cop1 and pifQ mutants.

212 tes are essential for defining the molecular phenotypes of cells.

213 f the lung associates with distinct clinical phenotypes of COPD, including increased exacerbation sus

214 tion can be seen in the complex pathological phenotypes of FUT8 null mice, which display defects in c

215 tinal and choroidal thinning, characteristic phenotypes of GA, were driven by continuous choroidal MC

216 in tissue-enrichment information can explain phenotypes of genetic diseases, which cannot be obtained

217 gnin degradation and cell growth are crucial phenotypes of lignin-utilizing bacteria, but their inter

218 a pipeline to automatically detect high-risk phenotypes of LVH in participants undergoing CAC-CT, wit

219 Phenotypes of poor prognosis included ADEM-like relapses

220 esolved, single-cell analysis identified the phenotypes of tumour and stromal single cells, their org

221 Advanced phenotyping of cardiovascular diseases has evolved with

222 The mechanical phenotyping of single cells therefore offers many potent

223 We measured phenotypes on a 216-year time series of Arabidopsis thal

224 ing to identify individuals with distinct BA phenotypes or 'ageotypes'.

225 nt for MRI and tau-PET and may differ across phenotypes, particularly for MRI.

226 orbid conditions; (2) repositories of deeply phenotyped physiological data and human tissue, made acc

227 rtCube, a high-throughput unbiased automated phenotyping platform that collects >2000 behavioral feat

228 authors revealed a distinct tolerant B cell phenotype possessing the ability to suppress naive B cel

229 onsistently outperforms competing methods in phenotype prediction.

230 beta, switched microglial polarization to M2 phenotype, prevented Th1 infiltration, and increased Th2

231 herited forms of CKD frequently span diverse phenotypes, reflecting genetic phenomena including pleio

232 We quantified 12 atherosclerosis-relevant phenotypes related to calcification, proliferation, and

233 e interactome networks that mediate genotype-phenotype relationships(1,2).

234 2-Na/K ATPase mutations lead to the migraine phenotype remain incompletely understood.

235 otective immunity, the pathways driving this phenotype remain unclear.

236 elial cell metabolism to support the dynamic phenotype remains to be established.

237 , floral abscission, and stomatal patterning phenotypes, respectively.

238 This phenotype resulted from enhanced growth rate and a delay

239 physicochemical descriptors and 36 in vitro phenotypes revealed that chlorination status and metabol

240 Investigate the endothelial cell phenotype (s) that causes Shock-Induced Endotheliopathy

241 elated cardiomyopathy manifested a malignant phenotype-SCD occurred in 30 (53%) of 57 affected indivi

242 ) pump is one of the key determinants of the phenotypes seen in various muscle tissues.

243 nsory-motor circuit to improve the SMA motor phenotype.SIGNIFICANCE STATEMENT Spinal muscular atrophy

244 in Arabidopsis plants with a rapid flowering phenotype similar to that of plants with mutations in lh

245 lls while disordered ECM drove a mesenchymal phenotype, similar to well and poorly differentiated tum

246 ei, making it difficult to ascribe resulting phenotypes solely to the inner ear.

247 5 give rise to related synaptic transmission phenotypes, specific alterations in spontaneous neurotra

248 od asthma and demonstrates the importance of phenotype-specificity for discovery of asthma genes and

249 that drives a metastatic, therapy-resistant phenotype, stabilizes the half-life of p53 and uses p53

250 rstood how TNF can lead to different disease phenotypes such as destructive peripheral polysynovitis

251 the ability of affecting clinically relevant phenotypes such as virulence, host colonization, sporula

252 Latitudinal patterns in stickleback plate phenotypes suggest that evolution at Eda is a response t

253 ly complement sgn3 Casparian strip formation phenotypes, suggesting that SERK proteins also mediate G

254 cancer cells manifest overlapping metabolic phenotypes, suggesting that they may be targeted via a c

255 This targeted delivery improves phenotype switching of TAMs from pro- towards anti-tumor

256 gh-altitude mice had a more oxidative muscle phenotype than low-altitude mice.

257 Myom2-RFP(+) PSC-CMs exhibited more mature phenotypes than RFP(-) cells in morphology, function and

258 BBB model that displays an adhesion molecule phenotype that is suitable for the study of immune cell

259 l cortex (PFC), contributing to a behavioral phenotype that mimics multiple symptoms associated with

260 alibrated to the tissue being tested and for phenotypes that become manifest in older ages.

261 y allows genomes to encode multiple distinct phenotypes that can be differentially manifested in resp

262 CTNND1 in Xenopus, we identified a subset of phenotypes that can be linked to p120-catenin in epithel

263 Several phenotypes that impact the capacity of cancer cells to s

264 psychiatric categories to create informative phenotypes that improve clinical prediction and clarify

265 val, null mutations often have embryo lethal phenotypes that prevent elucidation of subtle, but physi

266 retome educated macrophages towards tolerant phenotypes that promoted CD8(+) T cell dysfunction.

267 elial integrity and turnover, and additional phenotypes that suggest mesenchymal roles of CTNND1.

268 homologous recombination deficient cellular phenotypes, the image-based algorithm was studied prospe

269 l knockout mice did not reveal developmental phenotypes, the restricted pattern of Fgf8 expression su

270 gen organization regulate cardiac fibroblast phenotype through mechanical activation of p38-YAP-TEAD

271 Each protein introduces a unique phenotype to chromatin organization, and these structure

272 an adopt both pro-inflammatory or reparative phenotypes to modulate inflammatory and reparative respo

273 Novel variants were evaluated by recombinant phenotyping to assess their potential to confer resistan

274 In addition to phenotype tools, genetic analysis tools enable users to

275 scriptional correlates of depression imaging phenotypes track gene down-regulation in postmortem cort

276 Regional heterogeneity in phenotype trends indicates complex responses to spatiote

277 s; tumors that shift towards the mesenchymal phenotype upon recurrence are generally associated with

278 iction schemes through comprehensive digital phenotyping using structured and unstructured data abstr

279 ted with death, whereas the gastrointestinal phenotype was associated with recovery.

280 Increase occurrence of a blistered wing phenotype was found in a subset of PAMAM-CNT-dsRNA(alpha

281 The association between VPA and LVNC phenotype was independent of LV volumes.

282 Although a disease phenotype was not immediately obvious, persistent low le

283 This novel BAT-Kiss1r KO phenotype was of greater magnitude in females and was as

284 This in vivo MT phenotype was reproduced in vitro when cells were co-cul

285 Using detailed clinical phenotyping, we find novel associations between autoanti

286 Although cells with a Th1 phenotype were the predominant subset at baseline, cells

287 These phenotypes were not correlated with each other.

288 Importantly, these phenotypes were not observed in clones with LRRK2 trunca

289 Phenotypes were scored for severity of skin condition, s

290 phyB mutants exhibited a freezing-sensitive phenotype, whereas phyB-overexpression transgenic plants

291 clinical overview of the NF-kappaB1-related phenotype, which includes immunodeficiency, autoimmunity

292 PK6, MKK4 and MKK5, or YDA show a short-root phenotype, which is associated with reduced mitotic acti

293 Pif1 exacerbated its overexpression toxicity phenotype, which was alleviated upon deletion of its N t

294 t PDK1/SGK3 signaling to promote tumorigenic phenotypes, which are all abolished upon inhibition of A

295 SLG1 results in plants with thermosensitive phenotype, while overexpression of SLG1 enhances the tol

296 epletion in zebrafish mimicked the patients' phenotype with early lethality, defects in neurogenesis

297 n of B1 in awned wheat produced an awnletted phenotype with pleiotropic effects on plant height and f

298 studies (meta-GWASs) of the broad depression phenotype with those from meta-GWASs of self-reported an

299 multiple myc mutants share light-associated phenotypes with mutants of the phytochrome B photorecept

300 g its expression causes severe diabetes-like phenotypes without markedly causing peripheral insulin r