ライフサイエンスコーパス: phenotypic screen

1 ed for apicoplast biogenesis identified in a phenotypic screen.

2 interesting activity against T. brucei in a phenotypic screen.

3 olecular targets, or to create libraries for phenotypic screens.

4 phosphoramide mustards using biochemical and phenotypic screens.

5 est and efforts in prosecuting mycobacterial phenotypic screens.

6 the many compounds discovered in whole-cell phenotypic screens.

7 d predicted the molecular targets underlying phenotypic screens.

8 y subjected to a limited number of secondary phenotypic screens.

9 e hypomorphic epi-mutants in high-throughput phenotypic screens.

10 ified recently by their altered behaviors in phenotypic screens.

11 ing rates or distributions of mutations from phenotypic screens.

12 fication of the receptor deletion as well as phenotypic screens.

13 nd evaluating these analogues via cell-based phenotypic screens.

14 linked to fibroblast repair processes using phenotypic screens.

15 revious work conducted expensive large-scale phenotypic screens.

16 rgets for compounds found to be effective in phenotypic screens.

17 larly when these compounds are identified in phenotypic screens.

18 ery of many new lead compounds identified by phenotypic screening.

19 tient groups defined by signs, symptoms, and phenotypic screening.

20 by classical mutagenesis techniques based on phenotypic screening.

21 dic ALS (SALS) and conducted population-wide phenotypic screening.

22 ted great potential across multiple areas of phenotypic screening.

23 n-class small molecules were identified from phenotypic screening.

24 related to elements found to be powerful in phenotypic screening.

25 nome-scale guide RNA libraries for unbiased, phenotypic screening.

26 discovery project, applying high-throughput phenotypic screening across broad chemical diversity and

27 al biocides are often discovered using large phenotypic screens across hundreds of compounds, where v

28 This series was identified from a phenotypic screen against the blood stage of Plasmodium

29 minopyrimidines (TAPs), which emerged from a phenotypic screen against the blood stages of Pf.

30 brary, was identified from a high throughput phenotypic screen against the human malaria parasite Pla

31 Phenotypic screening against MCF7 mammary adenocarcinoma

32 mising class of antituberculosis agents from phenotypic screening against mycobacteria.

33 Phenotypic screens allow the identification of small mol

34 This multipronged phenotypic screen allowed us to reveal beta-oxidation pr

35 The phenotypic screening allowed identification of a mutant

36 model-directed discovery, interpretations of phenotypic screens, analysis of network properties and s

37 avin riboswitches, which was identified in a phenotypic screen and acts as a structurally distinct sy

38 model system, we performed a high-throughput phenotypic screen and defined compounds that overcame di

39 as an inhibitor of HIV-1 infectivity using a phenotypic screen and derivatives of this compound were

40 These compounds were discovered from a TNBC phenotypic screen and possess a unique dual inhibition p

41 This phenotypic screen and subsequent analysis identified ARA

42 monstrate the utility of this population for phenotypic screening and associated genomic characteriza

43 evelopment by random mutagenesis followed by phenotypic screening and by targeted gene disruption fol

44 ing stem cell proliferation responses with a phenotypic screening and by using specific knockdowns.

45 cision-making assays ranging from whole-cell phenotypic screening and cytotoxicity to aqueous solubil

46 nstrate the power of combining iPSC-CMs with phenotypic screening and deep learning to accelerate dru

47 h available SALK T-DNA mutagenesis lines for phenotypic screening and identified two previously unrep

48 erties against several neurotoxic drugs in a phenotypic screening and is shown to protect axons in an

49 oughput pharmacodynamic assays, accelerating phenotypic screening and personalized medicine.

50 Phenotypic screening and structure-activity relationship

51 This phenotypic screening and subsequent analysis identified

52 s fully functionalized probes for integrated phenotypic screening and target identification.

53 reens are certain to change the paradigm for phenotypic screening and will be discussed.

54 ter than traditional compound collections in phenotypic screens and against difficult targets.

55 st new tuberculosis drug leads discovered by phenotypic screens and genome sequencing are highly lipo

56 in genetic background, so that results from phenotypic screens and other related experiments might n

57 al assaying of this important gene family in phenotypic screens and their use in biochemical and stru

58 rug target identification, drug repurposing, phenotypic screening, and side effect prediction.

59 enome-wide miRNA mimic and hairpin inhibitor phenotypic screens, and miRNA-mRNA transcriptomics analy

60 These findings establish a genomics-based phenotypic screening approach capable of quickly connect

61 Here we report a phenotypic screening approach in which cytotoxins whose

62 lop agents for the treatment of influenza, a phenotypic screening approach utilizing a cell protectio

63 The gene biomarker-based phenotypic screening approach was developed, and 3,4-dis

64 n of the model described here as an unbiased phenotypic screening approach will help with our long te

65 as historically benefited from a whole-cell (phenotypic) screening approach to identify lead molecule

66 results support SNF integration of multiple phenotypic screening approaches along with untargeted me

67 mutational studies, adaptive evolution, and phenotypic screening are powerful tools for creating new

68 ing human disorders are genetically complex, phenotypic screens are difficult to design.

69 Large-scale phenotypic screens are ongoing to identify anticryptospo

70 targeted knockdown strategies combined with phenotypic screens are powerful approaches to delineate

71 bination of diversity-oriented synthesis and phenotypic screening as a strategy for the discovery of

72 Using unbiased phenotypic screens as an alternative to target-based app

73 es and random point mutagenesis, followed by phenotypic screening based on a yeast two-hybrid system.

74 , polA, and hfq, were isolated with the same phenotypic screen, but they do not affect the beta-galac

75 crease the efficiency, scale and accuracy of phenotypic screens by maximizing their discriminatory po

76 al 5A (NS5A) protein have been identified by phenotypic screening campaigns using HCV subgenomic repl

77 or constructing conventional high-throughput phenotypic screening campaigns.

78 recision/personalized medicine, wherein this phenotypic screen can be coupled with current DNA pharma

79 Our study demonstrates that high-throughput phenotypic screening can uncover rich genetic diversity

80 Phenotypic screens can identify molecules that are at on

81 Chemical libraries paired with phenotypic screens can now readily identify compounds wi

82 By using a combination of phenotypic screening, chemoproteomics, and biophysical s

83 f optimized MMP inhibitors that went through phenotypic screening consisting of thromboelastometry an

84 Both siRNA and drug phenotypic screening converge to implicate the phosphoin

85 Phenotypic screening coupled with transcriptome sequenci

86 onditions were compared with high-throughput phenotypic screen data, and the initial in silico model

87 A simple F1 adult phenotypic screen demonstrated that most adult tissues c

88 knockout mice were subjected to a systematic phenotypic screen designed to uncover alterations in emb

89 pment of PTM-centric base editing coupled to phenotypic screens, directed by temporally resolved phos

90 ogical processes and could be used for rapid phenotypic screening (e.g., to produce plants with super

91 silico screening protocols able to simulate phenotypic screening experiments.

92 These results demonstrate that phenotypic screening, followed by comprehensive MoA effo

93 indicators (GCaMPs) to develop a cell-based phenotypic screen for compounds that modulate Ca(2+) sig

94 In total, this work demonstrated a new phenotypic screen for discovery of natural products that

95 A cell-based phenotypic screen for inhibitors of biofilm formation in

96 nse method of random gene inactivation and a phenotypic screen for limitation of ASFV replication in

97 In a phenotypic screen for lymphomagenesis, we tested candida

98 identical phenotype was discovered during a phenotypic screen for mutations induced by chemical muta

99 ehavioral changes could be used as a primary phenotypic screen for new drug candidates, if enough use

100 Here, we perform a phenotypic screen for pTau accumulation in AD-patient iP

101 Here, we describe a phenotypic screen for small molecules that reverse TDP-4

102 Phenotypic screening for additional cases from a large A

103 loped for cancer therapy: many discovered by phenotypic screening for cancer cell death have low nano

104 ferred to as "SD70," initially identified by phenotypic screening for inhibitors of ligand and genoto

105 Phenotypic screening for resistant cultivars is however

106 esults demonstrate the utility of cell-based phenotypic screening for Select Agent drug discovery and

107 Our findings underscore the benefits of phenotypic screening for targeting post-translational mo

108 Phenotypic screens for bactericidal compounds against dr

109 Phenotypic screens for bactericidal compounds are starti

110 We conducted phenotypic screens for small molecules that inhibit TGF-

111 st commonly employed two general strategies: phenotypic screens for spontaneous or induced mutations

112 tablish the practicality of loss-of-function phenotypic screens for the identification of genomic loc

113 Phenotypic screening found that 2,3,6-trisubstituted qui

114 Cyclotide MCoCP4 was selected by phenotypic screening from cells transformed with a mixtu

115 High-throughput cell-based phenotypic screening has become an increasingly importan

116 High-content phenotypic screening has become the approach of choice f

117 Image-based phenotypic screening has emerged as a powerful tool for

118 Phenotypic screening has yielded small-molecule inhibito

119 High-throughput phenotypic screens have re-emerged as screening tools in

120 Phenotypic screens have the advantage of the whole organ

121 echanisms of actions of drugs, discovered by phenotypic screening, have been elucidated.

122 High-content image-based phenotypic screens (HCSs) provide a scalable approach to

123 Successful optimization of a phenotypic screening hit based on a quinoline-4-carboxam

124 10 was optimized from a phenotypic screening hit utilizing insights from X-ray c

125 n peptidic amino alcohols originating from a phenotypic screening hit, we have here developed a serie

126 950 (developed by Pfizer) were discovered by phenotypic screening, however their mode of action was o

127 An automated high-throughput phenotypic screen identified several small molecules as

128 Our previous phenotypic screening identified styrylquinoline UCF501 a

129 In addition, a phenotypic screen identifies T0 plants with the expected

130 d neuroprotective compound, discovered via a phenotypic screen, imparts its beneficial effects by tar

131 Herein we describe a high throughput, phenotypic screen in cells that led to the discovery of

132 veloped by combining ligand-based design and phenotypic screening in an iterative manner.

133 We have conducted a phenotypic screening in endothelial cells exposed to ele

134 f the inactive E96A mutant cDNA, followed by phenotypic screening in Escherichia coli, led to isolati

135 By integrating image-based phenotypic screening in HeLa cells with high-resolution

136 In the absence of a validated drug target, phenotypic screening in model organisms provides a route

137 genomics approach that combines genome-wide phenotypic screening in primary murine macrophages with

138 age-gated K+ channel, Kat1, is combined with phenotypic screening in Saccharomyces cerevisiae and ele

139 These results demonstrate the utility of phenotypic screening in the identification of residues c

140 An unbiased phenotypic screening in TNNT2 mutant iPSC-derived cardio

141 cut lung slice (PCLS) screening ex vivo, and phenotypic screening in vivo, we identified a HSP90 inhi

142 Phenotypic screening in zebrafish revealed that the expr

143 Genome-wide phenotypic screens in the budding yeast Saccharomyces ce

144 This study underscores the power of phenotypic screens in the development and characterizati

145 ntimalarial compounds, previously found in a phenotypic screen, into a PfHsp90-specific pocket.

146 However, it is equally applicable to general phenotypic screening involving helminths and other compl

147 Phenotypic screening is a powerful approach to identify

148 Phenotypic screening is a powerful method in both neglec

149 Phenotypic screening is an unbiased method to screen for

150 Small molecule in vivo phenotypic screening is used to identify drugs or biolog

151 A central challenge in designing phenotypic screens is choosing suitable imaging biomarke

152 C-nucleoside 4 (RSV A2 EC(50) = 530 nM) as a phenotypic screening lead targeting the RSV RNA-dependen

153 Our cell-based phenotypic screening led to the discovery of novel triaz

154 ecules previously identified in a C. elegans phenotypic screen likely to be enriched for feeding regu

155 ghlights recent advances and progress toward phenotypic screening methodologies over the past several

156 Here we develop high-content phenotypic screening methods for the systematic identifi

157 based on the C-terminal region of Psu using phenotypic screening methods.

158 As part of our large-scale phenotypic screen, mice deficient for the Arl3 gene were

159 A phenotypic screen of a compound library for antiparasiti

160 ization of a hit compound resulting from the phenotypic screen of a library of compounds against T. c

161 A phenotypic screen of a set of S. lycopersicum M82 x Sola

162 Utilizing a phenotypic screen of an approved drug collection, we fou

163 ced short palindromic repeats (CRISPR)-based phenotypic screen of class I and II HDAC genes.

164 visceral leishmaniasis, were identified in a phenotypic screen of Leishmania infantum.

165 psis (Arabidopsis thaliana) reverse genetics phenotypic screen of more than 5,000 mutants.

166 A phenotypic screen of mouse gene knockouts led to the dis

167 racteristic traits was explored to perform a phenotypic screen of near-isogenic short-culm mutant lin

168 report the results of the first phase of our phenotypic screen of the 12,657 compounds of the Scripps

169 An systematic phenotypic screen of the mouse gut microbiome for metabo

170 In a phenotypic screen of the wild-derived mouse strain MOLF/

171 Phenotypic screening of a cereblon (CRBN)-biased chemica

172 Phenotypic screening of a GBS transposon insertion libra

173 Here, we report a phenotypic screening of a human secretome library in hum

174 Here, phenotypic screening of a human/hamster radiation hybrid

175 Phenotypic screening of a library of type II human kinas

176 Phenotypic screening of a Medicines for Malaria Venture

177 Our phenotypic screening of a TILLING mutant collection iden

178 line has recently disclosed the results of a phenotypic screening of an internal library, publishing

179 Genotypic and phenotypic screening of C. difficile isolates revealed m

180 ion, opening new options for region-specific phenotypic screening of complex physiological phenomena

181 or develop chemical scaffolds identified by phenotypic screening of compound libraries, specific pha

182 Here, we show that phenotypic screening of drug libraries in zebrafish scn1

183 ith severe hypercholesterolemia, followed by phenotypic screening of family members.

184 of genetic materials to mammalian cells for phenotypic screening of gene expression and gene silenci

185 tes the potential for using yeast to perform phenotypic screening of genetically encoded cyclotide-ba

186 limitation in important areas, including the phenotypic screening of human genes in transgenic mice b

187 ontargeted therapies are drugs identified by phenotypic screening of natural products or chemical lib

188 phenotype-driven approach that involves the phenotypic screening of organisms with randomly induced

189 lar cell-surface receptors, and we have used phenotypic screening of radiation hybrid cell lines to i

190 Phenotypic screening of representative examples against

191 By high-throughput phenotypic screening of small molecules, we identified c

192 ular cell barcoding to enable direct in vivo phenotypic screening of small-molecule libraries.

193 From the phenotypic screening of the AstraZeneca corporate compou

194 of the receptor gene in the human genome by phenotypic screening of the G3 human-hamster radiation h

195 ly precise localization might be achieved by phenotypic screening of the hybrids to facilitate positi

196 Phenotypic screening of the library identified disruptio

197 Phenotypic screening of the mini library against multipl

198 Phenotypic screening of the resulting oxazonine collecti

199 ble to infect Chinese hamster cells, we used phenotypic screening of the T31 mouse/hamster radiation

200 Phenotypic screening of U. maydis mutants deleted for ge

201 In the pursuit of new antimalarial leads, a phenotypic screening of various commercially sourced com

202 In phenotypic screens of Ca(2+) chelator and Mn(2+) toxicit

203 uberculosis (Mtb) have been advanced through phenotypic screens of extensive compound libraries.

204 We conducted phenotypic screens of libraries of Food and Drug Adminis

205 ead-one stock solution strategy that enabled phenotypic screens of the resulting library.

206 Phenotypic screening offers a powerful approach to ident

207 ased screening on pteridine reductase 1 with phenotypic screening on Trypanosoma brucei for hit ident

208 vity suitable for clinical use, we performed phenotypic screens on a NINDS small molecule library of

209 d the use of these workhorse collections for phenotypic screening or genetic mapping.

210 identification of new lead compounds include phenotypic screening or target-based approaches.

211 ion approaches for degraders discovered from phenotypic screens or monovalent glue chemistry campaign

212 In this review, we describe phenotypic screening paradigms that make use of nocicept

213 Here, we develop a large-scale phenotypic screening pipeline and use it to carry out a

214 we describe the development of an astrocyte phenotypic screening platform for identifying chemical m

215 A phenotypic screening platform using DCM iPSC-CMs was est

216 Large-scale phenotypic screening presents challenges and opportuniti

217 ecies were identified from a high-throughput phenotypic screening program of the 456 compounds belong

218 fully functionalized compound libraries into phenotypic screening programs should facilitate the disc

219 Phenotypic screens provide an effective platform to iden

220 Phenotypic screening provides a complementary approach t

221 Phenotypic screening provides a means to discover small

222 of action of the drugs found active in these phenotypic screens remain largely unknown.

223 Target-directed screening and whole-cell phenotypic screening represent two complementary approac

224 s for a hit compound that has emerged from a phenotypic screen resulting in indazole-based compounds.

225 g of 95 isolates identified by a preliminary phenotypic screen revealed that the lesions in them caus

226 Cell-based phenotypic screening revealed that noncytotoxic concentr

227 In a phenotypic screen seeking low-molecular-weight compounds

228 Finally, comprehensive phenotypic screening showed a broader pathological pheno

229 Phenotypic screening showed that some of these antibodie

230 The set of genes identified in this phenotypic screen shows only limited overlap with those

231 line, H23-KRAS(G12C) Using a combination of phenotypic screens, signaling analyses, and kinase inhib

232 which compounds discovered using cell-based phenotypic screening strategies might exert their effect

233 Here, we developed a phenotypic screening strategy for identifying factors th

234 High-content phenotypic screens such as Perturb-seq (CRISPR-based scr

235 vulnerability to ototoxin in a high-content phenotypic screening system.

236 the absence of an effective high-throughput phenotypic screening system.

237 Through phenotypic screening, systems analysis, and rigorous exp

238 Through the process of phenotypic screening, target deconvolution, and structur

239 usually reported as G6PD "normal" by current phenotypic screening tests.

240 We recently identified a compound through phenotypic screening that blocked infectivity of this in

241 richia coli by employing an extensive set of phenotypic screens that allow us to monitor the function

242 Furthermore, we summarize the types of phenotypic screens that can be performed to explore vari

243 pyrrolopyrimidine series, identified through phenotypic screening, that offers an opportunity to impr

244 entification of the molecular targets from a phenotypic screen, the confirmation of the in vivo relev

245 With the use of a phenotypic screen, the deletion frequency of identical r

246 study addresses three inherent challenges in phenotypic screening: the identification of the molecula

247 EC50) values using image-based readouts from phenotypic screens, thereby allowing rigorous comparison

248 Phenotypic screening therefore retains a niche in drug d

249 tor ezutromid/SMT C1100 was developed from a phenotypic screen through to a Phase 2 clinical trial.

250 de (CCT251236), identified using an unbiased phenotypic screen to detect inhibitors of the HSF1 stres

251 the NMNAT2-MSD platform provides a sensitive phenotypic screen to detect NMNAT2 in neurons.

252 s of 1,3,4-oxadiazole-3-ones identified in a phenotypic screen to have high antibacterial potency aga

253 We developed a phenotypic screen to isolate genes that contribute to th

254 we combine saturation mutagenesis and multi-phenotypic screening to dissect the impact of 11,213 mis

255 Multiple labs have used phenotypic screening to identify dozens of drugs that en

256 rovides a compelling example of the power of phenotypic screening to identify leads engaging novel ta

257 this study demonstrates the power of in vivo phenotypic screening to identify new classes of 'cancer

258 bine fragment-based chemical proteomics with phenotypic screening to identify small molecules that pr

259 e, it is often a challenge in small molecule phenotypic screening to infer the causality between a pa

260 Here, we used phage display phenotypic screening to isolate antibodies that alter th

261 Here we employ high-throughput phenotypic screening to systematically test pairwise com

262 lian cells has provided the means to perform phenotypic screens to determine the functions of genes.

263 jected to a battery of primary and secondary phenotypic screens to identify photosynthesis-related mu

264 fication and validation, to target-based and phenotypic screens, to clinical trials.

265 gets for orphan clinical drugs and hits from phenotypic screens, to identify off-targets, and to expl

266 A phenotypic screen uncovered the N-aryl acetamide class t

267 ries from a high-throughput resistance-based phenotypic screen using Mycobacterium bovis BCG over-exp

268 Phenotypic screening using CLIMET represents a valuable

269 However, phenotypic screening using rodent models is labor intens

270 rentiation can be identified via multiplexed phenotypic screening using thousands of miniaturized org

271 High-throughput phenotypic screens using biochemical perturbations and h

272 Cell-based phenotypic screens using small molecule inhibitors is an

273 A hit from a phenotypic screen was optimized to give a compound with

274 In parallel, a phenotypic screen was performed for compounds that alter

275 A high-throughput, phenotypic screen was used to identify a small molecule

276 A phenotypic screen was used to search for drug-like molec

277 Therefore, the gene biomarker-based phenotypic screening was demonstrated as a promising too

278 An unexpected impurity from a phenotypic screening was optimized as a series of dimeri

279 Using an antisense-based phenotypic screen, we discovered the role of calpains in

280 Using an inbred mouse neuronal phenotypic screen, we find that CAST/Ei mouse adult dors

281 Using RNA-mediated genetic interference in a phenotypic screen, we identified a conserved nonmuscle m

282 From an unbiased cell-based circadian phenotypic screen, we identified KL001, a small molecule

283 Using a phenotypic screen, we identified resveratrol as an agent

284 Using a phenotypic screen, we identify a small molecule, disperg

285 subjecting the resulting guide library to a phenotypic screen, we uncover the sRNA BatR to increase

286 Using genome-wide ENU mutagenesis and phenotypic screening, we have identified a mouse line th

287 ving random transposon mutagenesis and rapid phenotypic screening, we identified a murine cytomegalov

288 labeling differentiated oligodendrocytes for phenotypic screening, we identified a small-molecule epi

289 Based on a series of phenotypic screens, we identified a hit targeting this p

290 predict targets, drug development relied on phenotypic screening, where the effectiveness of candida

291 ies glycosphingolipid (GSL) synthesis, via a phenotypic screen, which previously yielded iGb(3) synth

292 Phenotypic screens, which focus on measuring and quantif

293 Furthermore, we show image-based phenotypic screens, which reveal that the AKT kinase inh

294 we combine an immunofluorescence (IF)-based phenotypic screen with chemoproteomics to identify sulfo

295 Herein, we have combined phenotypic screening with a biased target-specific scree

296 By combining phenotypic screening with ShHTL structural information a

297 d from chemically induced mouse mutations by phenotypic screening with slit lamp examination.

298 In sum, our approach empowers phenotypic screens with information-rich readouts to adv

299 es from all 80 lineages were subjected to 39 phenotypic screens, with newly arising mutations detecte

300 ation of causative mutations concurrent with phenotypic screening, without the need to outcross mutan