ライフサイエンスコーパス: phenotypic screening

1 tient groups defined by signs, symptoms, and phenotypic screening.

2 by classical mutagenesis techniques based on phenotypic screening.

3 dic ALS (SALS) and conducted population-wide phenotypic screening.

4 ted great potential across multiple areas of phenotypic screening.

5 cal assays such as patient-specific drug and phenotypic screening.

6 These methods depend on extensive phenotypic screening.

7 2-dimethylhexanoic acid), was identified via phenotypic screening.

8 n-class small molecules were identified from phenotypic screening.

9 ient solution for large-scale, high-fidelity phenotypic screening.

10 nome-scale guide RNA libraries for unbiased, phenotypic screening.

11 ery of many new lead compounds identified by phenotypic screening.

12 related to elements found to be powerful in phenotypic screening.

13 discovery project, applying high-throughput phenotypic screening across broad chemical diversity and

14 Phenotypic screening against MCF7 mammary adenocarcinoma

15 mising class of antituberculosis agents from phenotypic screening against mycobacteria.

16 tituted indoles that were identified through phenotypic screening against T. cruzi.

17 We performed phenotypic screening against trypanosomes and identified

18 The phenotypic screening allowed identification of a mutant

19 monstrate the utility of this population for phenotypic screening and associated genomic characteriza

20 evelopment by random mutagenesis followed by phenotypic screening and by targeted gene disruption fol

21 ing stem cell proliferation responses with a phenotypic screening and by using specific knockdowns.

22 cision-making assays ranging from whole-cell phenotypic screening and cytotoxicity to aqueous solubil

23 nstrate the power of combining iPSC-CMs with phenotypic screening and deep learning to accelerate dru

24 h available SALK T-DNA mutagenesis lines for phenotypic screening and identified two previously unrep

25 ghlights MorphDiff's potential to accelerate phenotypic screening and improve MOA identification, mak

26 erties against several neurotoxic drugs in a phenotypic screening and is shown to protect axons in an

27 oughput pharmacodynamic assays, accelerating phenotypic screening and personalized medicine.

28 of small-molecule degraders relies mostly on phenotypic screening and retrospective target identifica

29 Phenotypic screening and structure-activity relationship

30 This phenotypic screening and subsequent analysis identified

31 s fully functionalized probes for integrated phenotypic screening and target identification.

32 reens are certain to change the paradigm for phenotypic screening and will be discussed.

33 as enabled high-throughput reverse genetics, phenotypic screenings and analyses of synthetic-genetic

34 rug target identification, drug repurposing, phenotypic screening, and side effect prediction.

35 loy whole-genome sequencing, high-throughput phenotypic screenings, and genome-scale models of metabo

36 These findings establish a genomics-based phenotypic screening approach capable of quickly connect

37 Here we report a phenotypic screening approach in which cytotoxins whose

38 lop agents for the treatment of influenza, a phenotypic screening approach utilizing a cell protectio

39 The gene biomarker-based phenotypic screening approach was developed, and 3,4-dis

40 n of the model described here as an unbiased phenotypic screening approach will help with our long te

41 as historically benefited from a whole-cell (phenotypic) screening approach to identify lead molecule

42 results support SNF integration of multiple phenotypic screening approaches along with untargeted me

43 mutational studies, adaptive evolution, and phenotypic screening are powerful tools for creating new

44 bination of diversity-oriented synthesis and phenotypic screening as a strategy for the discovery of

45 es and random point mutagenesis, followed by phenotypic screening based on a yeast two-hybrid system.

46 al 5A (NS5A) protein have been identified by phenotypic screening campaigns using HCV subgenomic repl

47 or constructing conventional high-throughput phenotypic screening campaigns.

48 Our study demonstrates that high-throughput phenotypic screening can uncover rich genetic diversity

49 By using a combination of phenotypic screening, chemoproteomics, and biophysical s

50 f optimized MMP inhibitors that went through phenotypic screening consisting of thromboelastometry an

51 Both siRNA and drug phenotypic screening converge to implicate the phosphoin

52 Phenotypic screening coupled with transcriptome sequenci

53 These large matched phenotypic screening datasets (initial and well-randomiz

54 en a vital feature of the hits obtained from phenotypic screenings despite the use of varied assay co

55 ogical processes and could be used for rapid phenotypic screening (e.g., to produce plants with super

56 Through a phenotypic screening employing viral pseudotypes and our

57 silico screening protocols able to simulate phenotypic screening experiments.

58 These results demonstrate that phenotypic screening, followed by comprehensive MoA effo

59 Phenotypic screening for additional cases from a large A

60 loped for cancer therapy: many discovered by phenotypic screening for cancer cell death have low nano

61 ferred to as "SD70," initially identified by phenotypic screening for inhibitors of ligand and genoto

62 Phenotypic screening for resistant cultivars is however

63 esults demonstrate the utility of cell-based phenotypic screening for Select Agent drug discovery and

64 Our findings underscore the benefits of phenotypic screening for targeting post-translational mo

65 Phenotypic screening found that 2,3,6-trisubstituted qui

66 Cyclotide MCoCP4 was selected by phenotypic screening from cells transformed with a mixtu

67 High-throughput cell-based phenotypic screening has become an increasingly importan

68 High-content phenotypic screening has become the approach of choice f

69 Image-based phenotypic screening has emerged as a powerful tool for

70 Phenotypic screening has yielded small-molecule inhibito

71 echanisms of actions of drugs, discovered by phenotypic screening, have been elucidated.

72 Successful optimization of a phenotypic screening hit based on a quinoline-4-carboxam

73 10 was optimized from a phenotypic screening hit utilizing insights from X-ray c

74 n peptidic amino alcohols originating from a phenotypic screening hit, we have here developed a serie

75 950 (developed by Pfizer) were discovered by phenotypic screening, however their mode of action was o

76 Our previous phenotypic screening identified styrylquinoline UCF501 a

77 veloped by combining ligand-based design and phenotypic screening in an iterative manner.

78 We have conducted a phenotypic screening in endothelial cells exposed to ele

79 f the inactive E96A mutant cDNA, followed by phenotypic screening in Escherichia coli, led to isolati

80 By integrating image-based phenotypic screening in HeLa cells with high-resolution

81 In the absence of a validated drug target, phenotypic screening in model organisms provides a route

82 anization, generating a dataset suitable for phenotypic screening in neural models.

83 genomics approach that combines genome-wide phenotypic screening in primary murine macrophages with

84 oved ASDs were originally discovered through phenotypic screening in rodent models of seizures.

85 age-gated K+ channel, Kat1, is combined with phenotypic screening in Saccharomyces cerevisiae and ele

86 These results demonstrate the utility of phenotypic screening in the identification of residues c

87 An unbiased phenotypic screening in TNNT2 mutant iPSC-derived cardio

88 cut lung slice (PCLS) screening ex vivo, and phenotypic screening in vivo, we identified a HSP90 inhi

89 Phenotypic screening in zebrafish revealed that the expr

90 ed at viral or host factors and results from phenotypic screenings in cellular assay systems for vira

91 However, it is equally applicable to general phenotypic screening involving helminths and other compl

92 Phenotypic screening is a powerful approach to identify

93 Phenotypic screening is a powerful method in both neglec

94 Phenotypic screening is an unbiased method to screen for

95 Small molecule in vivo phenotypic screening is used to identify drugs or biolog

96 C-nucleoside 4 (RSV A2 EC(50) = 530 nM) as a phenotypic screening lead targeting the RSV RNA-dependen

97 Our cell-based phenotypic screening led to the discovery of novel triaz

98 ghlights recent advances and progress toward phenotypic screening methodologies over the past several

99 Here we develop high-content phenotypic screening methods for the systematic identifi

100 based on the C-terminal region of Psu using phenotypic screening methods.

101 Through a phenotypic screening of >30 mouse lines deficient in lip

102 Phenotypic screening of a cereblon (CRBN)-biased chemica

103 Phenotypic screening of a GBS transposon insertion libra

104 Here, we report a phenotypic screening of a human secretome library in hum

105 Here, phenotypic screening of a human/hamster radiation hybrid

106 Phenotypic screening of a library of type II human kinas

107 Phenotypic screening of a Medicines for Malaria Venture

108 Our phenotypic screening of a TILLING mutant collection iden

109 line has recently disclosed the results of a phenotypic screening of an internal library, publishing

110 Genotypic and phenotypic screening of C. difficile isolates revealed m

111 ion, opening new options for region-specific phenotypic screening of complex physiological phenomena

112 or develop chemical scaffolds identified by phenotypic screening of compound libraries, specific pha

113 Here, we show that phenotypic screening of drug libraries in zebrafish scn1

114 ith severe hypercholesterolemia, followed by phenotypic screening of family members.

115 of genetic materials to mammalian cells for phenotypic screening of gene expression and gene silenci

116 tes the potential for using yeast to perform phenotypic screening of genetically encoded cyclotide-ba

117 limitation in important areas, including the phenotypic screening of human genes in transgenic mice b

118 ontargeted therapies are drugs identified by phenotypic screening of natural products or chemical lib

119 phenotype-driven approach that involves the phenotypic screening of organisms with randomly induced

120 Utilizing high-throughput phenotypic screening of primary keratinocytes, we identi

121 lar cell-surface receptors, and we have used phenotypic screening of radiation hybrid cell lines to i

122 Phenotypic screening of representative examples against

123 By high-throughput phenotypic screening of small molecules, we identified c

124 ular cell barcoding to enable direct in vivo phenotypic screening of small-molecule libraries.

125 From the phenotypic screening of the AstraZeneca corporate compou

126 vel quinoline and quinazoline series through phenotypic screening of the ChemDiv library against Mtb-

127 of the receptor gene in the human genome by phenotypic screening of the G3 human-hamster radiation h

128 ly precise localization might be achieved by phenotypic screening of the hybrids to facilitate positi

129 Phenotypic screening of the library identified disruptio

130 Phenotypic screening of the mini library against multipl

131 Phenotypic screening of the resulting oxazonine collecti

132 ble to infect Chinese hamster cells, we used phenotypic screening of the T31 mouse/hamster radiation

133 Phenotypic screening of U. maydis mutants deleted for ge

134 In the pursuit of new antimalarial leads, a phenotypic screening of various commercially sourced com

135 By using whole-transcriptome analyses and phenotypic screenings of the marine bacterium Phaeobacte

136 Phenotypic screening offers a powerful approach to ident

137 ased screening on pteridine reductase 1 with phenotypic screening on Trypanosoma brucei for hit ident

138 d the use of these workhorse collections for phenotypic screening or genetic mapping.

139 identification of new lead compounds include phenotypic screening or target-based approaches.

140 In this review, we describe phenotypic screening paradigms that make use of nocicept

141 Here, we develop a large-scale phenotypic screening pipeline and use it to carry out a

142 we describe the development of an astrocyte phenotypic screening platform for identifying chemical m

143 We develop a high-content phenotypic screening platform to identify compounds that

144 A phenotypic screening platform using DCM iPSC-CMs was est

145 Their viability for medium/high-throughput phenotypic screening presents a promising avenue via whi

146 Large-scale phenotypic screening presents challenges and opportuniti

147 ecies were identified from a high-throughput phenotypic screening program of the 456 compounds belong

148 fully functionalized compound libraries into phenotypic screening programs should facilitate the disc

149 Phenotypic screening provides a complementary approach t

150 Phenotypic screening provides a means to discover small

151 Target-directed screening and whole-cell phenotypic screening represent two complementary approac

152 Cell-based phenotypic screening revealed that noncytotoxic concentr

153 Finally, comprehensive phenotypic screening showed a broader pathological pheno

154 Phenotypic screening showed that some of these antibodie

155 which compounds discovered using cell-based phenotypic screening strategies might exert their effect

156 Here, we developed a phenotypic screening strategy for identifying factors th

157 vulnerability to ototoxin in a high-content phenotypic screening system.

158 the absence of an effective high-throughput phenotypic screening system.

159 Through phenotypic screening, systems analysis, and rigorous exp

160 Through the process of phenotypic screening, target deconvolution, and structur

161 nt plasmodium-specific aaRS inhibitors using phenotypic screening, target validation, and structure-g

162 usually reported as G6PD "normal" by current phenotypic screening tests.

163 We recently identified a compound through phenotypic screening that blocked infectivity of this in

164 pyrrolopyrimidine series, identified through phenotypic screening, that offers an opportunity to impr

165 study addresses three inherent challenges in phenotypic screening: the identification of the molecula

166 Phenotypic screening therefore retains a niche in drug d

167 ablish biologically relevant models that use phenotypic screening to detect drug-induced toxicity in

168 we combine saturation mutagenesis and multi-phenotypic screening to dissect the impact of 11,213 mis

169 Using phenotypic screening to guide structure-activity relatio

170 Multiple labs have used phenotypic screening to identify dozens of drugs that en

171 rovides a compelling example of the power of phenotypic screening to identify leads engaging novel ta

172 this study demonstrates the power of in vivo phenotypic screening to identify new classes of 'cancer

173 bine fragment-based chemical proteomics with phenotypic screening to identify small molecules that pr

174 e, it is often a challenge in small molecule phenotypic screening to infer the causality between a pa

175 Here, we used phage display phenotypic screening to isolate antibodies that alter th

176 Here we employ high-throughput phenotypic screening to systematically test pairwise com

177 Phenotypic screening using CLIMET represents a valuable

178 However, phenotypic screening using rodent models is labor intens

179 rentiation can be identified via multiplexed phenotypic screening using thousands of miniaturized org

180 ayed, kinome focused siRNA and oncology drug phenotypic screening utilizing a set of syngeneic Ras mu

181 Rapid phenotypic screening, via modified mRNA transfection of

182 Therefore, the gene biomarker-based phenotypic screening was demonstrated as a promising too

183 An unexpected impurity from a phenotypic screening was optimized as a series of dimeri

184 Using genome-wide ENU mutagenesis and phenotypic screening, we have identified a mouse line th

185 ving random transposon mutagenesis and rapid phenotypic screening, we identified a murine cytomegalov

186 labeling differentiated oligodendrocytes for phenotypic screening, we identified a small-molecule epi

187 predict targets, drug development relied on phenotypic screening, where the effectiveness of candida

188 pecially important in campaigns arising from phenotypic screening, where the protein target and bindi

189 Herein, we have combined phenotypic screening with a biased target-specific scree

190 very for PAH can be accelerated by combining phenotypic screening with in silico analyses of publicly

191 By combining phenotypic screening with ShHTL structural information a

192 d from chemically induced mouse mutations by phenotypic screening with slit lamp examination.

193 ation of causative mutations concurrent with phenotypic screening, without the need to outcross mutan