ライフサイエンスコーパス: phenotypical

1 he present article will demonstrate that the phenotypical abnormalities attributed to the null mutati

2 ecific Lgp130 activation resulted in massive phenotypical abnormalities, including splenomegaly, lymp

3 examined Wwox-deficient (Wwox(-/-)) mice for phenotypical abnormalities.

4 of ARGs and of other resistant forms (e.g., phenotypical adaptations) in urban wastewater treatment

5 However, the underlying mechanisms of phenotypical alteration in chondrocytes areincompletely

6 intracellularvimentin network and consequent phenotypical alteration in human chondrocytes results in

7 in cell proliferation, and morphological and phenotypical alterations characteristic of an epithelial

8 Here we show ELT induces mechanistic and phenotypical alterations during experimental autoimmune

9 ss of SCD3 function did not cause detectable phenotypical alterations, endorsing the usefulness of Sc

10 Phenotypical analyses further suggest the novel possibil

11 Phenotypical analyses of the resulting mutant V. harveyi

12 Sequence and phenotypical analyses, and transmission of the replaceme

13 Through phenotypical analyses, we also established that simultan

14 The spatiotemporal expression profiling and phenotypical analysis of CRISPR loss-of-function mutants

15 Phenotypical analysis of serk single mutants is not stra

16 The phenotypical analysis of these mutant animals is complic

17 The phenotypical analysis of Txb21-deficient mice shows that

18 rpoB, and the intergenic spacer region) and phenotypical analysis supported the similarity of the th

19 Consistently, comprehensive phenotypical and analytical studies of S(1)-bZIP mutants

20 tribution and (4) identify associations with phenotypical and disease characteristics.

21 Unfortunately, genetic, phenotypical and environmental variation is much higher

22 Phenotypical and functional alterations in T cells were

23 in cultured endothelial cells (ECs) promoted phenotypical and functional alterations, including proli

24 We performed a phenotypical and functional analysis of several surface

25 Detailed phenotypical and functional analysis revealed that pDCs

26 involved in the initiation of CHS responses, phenotypical and functional characteristics of both fres

27 We analyzed phenotypical and functional characteristics of CMV-speci

28 The approach enabled mapping of known phenotypical and functional characteristics of fetal imm

29 egs showed a memory phenotype and shared all phenotypical and functional characteristics of nTregs.

30 al leukocyte population in the skin, showing phenotypical and functional characteristics of semimatur

31 skull 2-photon microscopy to investigate the phenotypical and functional characteristics of TAMs.

32 med in a subset of participants allowing for phenotypical and functional characterization of differen

33 Phenotypical and functional differences between liver an

34 Here, we uncovered a pronounced phenotypical and functional diversification of neutrophi

35 r certain advantages when insights into such phenotypical and functional features are of primary inte

36 Analyses of phenotypical and functional features revealed that iDMs

37 idual stromal calls and characterizing their phenotypical and functional features.

38 The phenotypical and functional heterogeneity of different m

39 ulations with distinct CSC contents based on phenotypical and functional properties, ranging from NN

40 played a critical role in the AML-EV-induced phenotypical and functional transition of monocytes.

41 in the developing mouse GM exhibit distinct phenotypical and likely functional characteristics compa

42 te myocardial infarction (AMI) and conducted phenotypical and metabolic characterizations.

43 The three subtypes displayed different phenotypical and molecular characteristics in terms of i

44 erstanding disease commonalities on both the phenotypical and molecular levels.

45 us disease, with variations observed at both phenotypical and molecular levels.

46 Our results expand the phenotypical and molecular spectrum of TRIP4-associated

47 A may be enhanced by refining taxonomy along phenotypical and pathophysiological "axes of risk," exte

48 to systematically review the face validity (phenotypical and pathophysiological resemblance with BD)

49 ., small secreted proteins (SSPs) that cause phenotypical and physiological changes in another organi

50 The subtle phenotypical and physiological changes in response to dr

51 This allows us to provide a detailed phenotypical and transcriptional profile of CD44-positiv

52 her types of muscle cells, characterized the phenotypical and transcriptomic changes in LMCs in aged

53 This study investigates morphological, phenotypical and transcriptomic features of alveolar reg

54 DC)-like cells, as defined by morphological, phenotypical, and functional criteria.

55 Functional, bioinformatic, phenotypical, and genetic approaches collectively establ

56 e showed that CART cells undergo functional, phenotypical, and transcriptomic changes of senescence,

57 shed by visual recognition of their distinct phenotypical appearance, as well as DNA analysis.

58 ater deficit regimes were analyzed through a phenotypical approach, including growth, physiological,

59 ponses to H2O2 as they relate to some of the phenotypical aspects of WS cells.

60 Phenotypical benefits extended beyond direct target sile

61 The phenotypical, biochemical and proteome data show that th

62 In isolated single mouse myometrial cells, a phenotypical bitter tastant (chloroquine, ChQ) reverses

63 oss drives NE differentiation, demarcated by phenotypical changes and NEPC marker expressions.

64 These phenotypical changes and the associated active deformati

65 the underlying mechanism for these observed phenotypical changes depends on enhanced autocrine/parac

66 Morphological and phenotypical changes during aging can also be monitored

67 We show that the phenotypical changes in collagen XIII knock-out mice are

68 ction, and their respective consequences for phenotypical changes in infected cells that might enable

69 We assessed pulmonary phenotypical changes in mev mice on the mast cell-defici

70 Animal models can be used to assess phenotypical changes in the absence of confounding facto

71 he Dermo1 lineage did not produce detectable phenotypical changes in the kidney.

72 Loss of IRF4 resulted in phenotypical changes of CD8(+) memory T cells but did no

73 dentification and characterization of subtle phenotypical changes of millimeter-sized organisms.

74 ed, although these animals displayed minimal phenotypical changes prior to adriamycin administration.

75 The range of phenotypical changes seen has implications for a propose

76 ciate alterations with initial appearance of phenotypical changes suggestive of bronchopulmonary dysp

77 ancer cells and adipocytes, which respond by phenotypical changes to generate fibroblast-like cells t

78 However, the attempt to interpret the phenotypical changes which arise in null-mutant mice is

79 Resistant cells display a spectrum of phenotypical changes with invasive phenotypes evolving i

80 and fetal compartments contributes to these phenotypical changes, it is unknown to what extent the s

81 filaments or laminin-332 results in similar phenotypical changes.

82 ypes and ignore the temporal dynamics of the phenotypical changes.

83 sample-to-sample variations from definitive phenotypical changes.

84 Differences in phenotypical characteristics between rare variant carrie

85 Phenotypical characteristics could help ophthalmologists

86 scriminated from noncarriers based solely on phenotypical characteristics from color fundus images.

87 se-dependent manner, thus, reproducing major phenotypical characteristics of DGAT-1(-/-) mice.

88 To describe the phenotypical characteristics of patients with AMD carryi

89 XP shares phenotypical characteristics with telomere-associated di

90 its human counterpart but has some distinct phenotypical characteristics.

91 group of diseases with varied molecular and phenotypical characteristics.

92 e emergence of novel variants with different phenotypical characteristics.

93 Genetic analysis and phenotypical characterization indicate that the M. xanth

94 st toxicity assays, confocal microscopy, and phenotypical characterization of a Transposable Element

95 Improved phenotypical characterization of all these infantile nys

96 l validation included lung X-ray imaging and phenotypical characterization of BPD severity levels.

97 nes and determining their cellular function, phenotypical characterization of genetic subtypes, and i

98 Phenotypical characterization of mutants in AGO genes an

99 Here, we report on the phenotypical characterization of two loss-of-function ze

100 Our thorough phenotypical characterization of USH2 mouse models is es

101 Phenotypical characterization revealed that loss of Cyli

102 Detailed phenotypical characterization showed anomalies in the ov

103 nies often reveal that taxa circumscribed by phenotypical characters are not monophyletic.

104 While re-examination of phenotypical characters often identifies the presence of

105 f exosomes makes direct characterization and phenotypical classification very difficult.

106 rgic receptor reveals three clearly distinct phenotypical clusters, showing selective impairments of

107 ventricular arrhythmia prevalence, severity, phenotypical context, and independent impact on outcome

108 We show that this phenotypical continuum can also be applied as a surrogat

109 res from endogenous molecules give rise to a phenotypical continuum that provides unique structural i

110 established brain structural divergences and phenotypical convergences of CNVs, with direct relevance

111 or residual covariance matrix instead of the phenotypical covariance matrix, based on which multiple

112 n murine erythroleukemia cells, resulting in phenotypical cross-correction in an enzyme-deficient lym

113 ate goal of haemophilia treatment would be a phenotypical cure achievable with gene therapy, currentl

114 Phenotypical data on melanocytic nevi were collected fro

115 to implement this approach and used existing phenotypical data to demonstrate its power.

116 Imaging, clinical, and phenotypical data were combined for multidimensional ana

117 In a subgroup of 40 people, childhood phenotypical data were compared with data on nevus numbe

118 Further analysis of this phenotypical defect revealed that loss of Cx43 expressio

119 However, we found that tumor cells have few phenotypical differences after surgery.

120 seling women at inherited risk, the inherent phenotypical differences between BRCA1 and BRCA2 mutatio

121 ue biological resource to determine relevant phenotypical differences between human and NHPs, and tha

122 shown to influence research results, explain phenotypical differences between inbred strains, and inc

123 The antibody panel captured the phenotypical differences in ADC cell lines and PBMC.

124 albumin) were inferred to be related to the phenotypical differences in animals from the different g

125 Taking advantage of phenotypical differences in animals with similar genotyp

126 Clear phenotypical differences were observed between cancerous

127 No gross phenotypical differences were observed between high-flav

128 Among other phenotypical differences, knock-out mice showed a signif

129 Phenotypical distinctions associated with UNC13A make it

130 e molecular networks to induce extraordinary phenotypical divergences.

131 plinary research programme investigating the phenotypical effects of single genes on hippocampal func

132 Biological and phenotypical effects were investigated using cell models

133 ulators of this process, we have performed a phenotypical enhancer screen using a null allele of cuc2

134 proteins whose interaction may be additional phenotypical evidence about the same functional process.

135 Their molecular evolution can underlie phenotypical evolution, but the contributions of the evo

136 knowledge-based mathematical model estimates phenotypical exposure risk such as toxic hepatopathy, di

137 The extraordinary degree of variation in phenotypical expression of this liver disease is believe

138 Thus, our study defines a core phenotypical feature underpinning a key common molecular

139 Comparison of in silico and phenotypical features align additional variants of unkno

140 ires a meticulous process of recognizing its phenotypical features and ascertaining the absence of st

141 ors, and suboptimal peri-implant soft tissue phenotypical features are relevant site-related factors.

142 air pigmentation were used to quantify other phenotypical features associated with albinism.

143 ionship between iris abnormalities and other phenotypical features of albinism.

144 Striking phenotypical features of MARC2 KO mice were lower body w

145 h include the analysis of several additional phenotypical features of the population, with the goal o

146 CoPP) markedly attenuated the development of phenotypical features of uremic cardiomyopathy.

147 Phenotypical features on fundus photographs of both eyes

148 from patients with juvenile-onset SLE share phenotypical features with CREMalpha-overexpressing CD4(

149 a new diagnostic approach to determine their phenotypical features.

150 lls increase in number but display distorted phenotypical features.

151 osed by means of SNP genotypes without using phenotypical features.

152 f uremic cardiomyopathy reversed many of the phenotypical features.

153 r decrease, maintaining astrocytes in the A2 phenotypical form possibly via decreasing C3 signaling a

154 te of CART cell dysfunction characterized by phenotypical, functional, and transcriptional changes of

155 f differential gene-gene correlations across phenotypical groups can help identify the activation/dea

156 ative disorders, cognitive impairment is the phenotypical hallmark of the disease.

157 Despite research advances, the phenotypical heterogeneity of patients with Friedrich's

158 not consistent but is characterized by great phenotypical heterogeneity which reflects the complex ef

159 road impacts on the study of gene functions, phenotypical heterogeneity, and genetic circuit control.

160 The phenotypical IKr currents in mouse AT-1 cells and Xenopu

161 ars, the identification of specific markers (phenotypical, immunological, and molecular) has led to t

162 valence of MITF p.E318K and its clinical and phenotypical implications has not been previously assess

163 abnormalities may persist after PDT despite phenotypical improvement of dysplasia.

164 ases cancer risk of patients by altering the phenotypical landscape and hierarchical organization of

165 organ-wide scale requires 3D anatomical and phenotypical maps, currently unavailable for many organs

166 on at mRNA level without alteration in other phenotypical markers on DCs.

167 On the basis of structure and expression of phenotypical markers, the emerging connective tissue cel

168 adds to the theoretical framework of female phenotypical masculinization via intrauterine position p

169 848 efficiently activated pDCs, resulting in phenotypical maturation as well as robust IFN-alpha and

170 eurons are generated in the first trimester, phenotypical maturation of A9 and A10 cell bodies contin

171 This phenotypical mBC signature predicting response to therap

172 Correlation with other phenotypical measurements, including (1) iris transillum

173 To deal with various forms of clinical and phenotypical measurements, we introduced four models to

174 ines and PDXs underwent histological, immune-phenotypical, molecular, and genomic characterization co

175 provide a comprehensive scenario of the main phenotypical, molecular, and immunological markers relat

176 Moreover, phenotypical-, molecular- and GA-analyses of various Ara

177 ional knockout (CKO) of Fgfr1 did not affect phenotypical number of HSPCs and homeostatic hematopoies

178 Phenotypical optimization of the oxygen cascade has been

179 lling studies indicate that PI4KA-associated phenotypical outcomes probably stem from impairment of P

180 x1 forelimb-expressing cells and more severe phenotypical outcomes.

181 s significantly associated with clinical and phenotypical outcomes.

182 Given phenotypical overlaps between loneliness and social anxi

183 g, direct experimental evidence that the two phenotypical pathways of bladder tumorigenesis are cause

184 clades as different genera each reflects the phenotypical pattern significantly better than accepting

185 Here, we examined whether these phenotypical patterns may relate to an overarching syste

186 Aging is associated with distinct phenotypical, physiological, and functional changes, lea

187 d failed to account for potential widespread phenotypical plasticity.

188 , we developed an integrated high-throughput phenotypical platform to probe for defects in cardiogene

189 f their axonal endings in the dlPAG led to a phenotypical presentation congruent with a 'freezing-lik

190 hese disorders are distinct, they overlap in phenotypical presentation.

191 disability display sex-biased prevalence and phenotypical presentations.

192 of the same genotype that display different phenotypical properties.

193 These mutations have a dynamic phenotypical range of bleeding from lack of platelet adh

194 e apply an evolution protocol to investigate phenotypical requirements for colonizing habitats of dif

195 ns of Mecp2-null mutant mice resulted in the phenotypical rescue of the symptoms.

196 hods, and high levels of concordance between phenotypical resistance and predicted resistance based o

197 of genes that regulate the material-induced phenotypical response of human mesenchymal stem cells.

198 he-Ade triggered diverse cytokinin-dependent phenotypical responses, it did not inhibit shoot growth

199 Phenotypical reversions were noted for both mutants when

200 tic perturbations, providing a mechanism for phenotypical robustness.

201 In a phenotypical screen of 56 acute myeloid leukemia (AML) p

202 Phenotypical screening assays involving adherent cell cu

203 ggressive tumors show a ubiquitous glandular phenotypical shift.

204 These two profiles constituted the phenotypical signature of the population.

205 er produced a striking series of alternating phenotypical signatures down the chain of infection.

206 better understanding the molecular basis of phenotypical signatures of glioblastoma, and provide ins

207 mouse having a glycine receptor (GlyR) with phenotypical silent mutations at KK385/386AA, we studied

208 an HO-1 deficiency was reported with several phenotypical similarities to the mouse HO-1 knockout.

209 sequently, tgfbeta1a morphant fish displayed phenotypical similarities with pcsk7 morphants, undersco

210 Cat4a shows phenotypical similarity to several other independent mou

211 4KA gene alteration as a cause of a variable phenotypical spectrum and provide fundamental new insigh

212 define ASC-1 neuromuscular function and the phenotypical spectrum associated with TRIP4 mutations.

213 he ATP8B1 gene characterized by a continuous phenotypical spectrum from intermittent (benign recurren

214 With the expanding phenotypical spectrum of atypical parkinsonian condition

215 cal spectrum and genetic findings expand the phenotypical spectrum of GNAO1-associated disorder and t

216 tients and expand the current mutational and phenotypical spectrum of the disease showing the clinica

217 brane domain mutant (TonB-delta V17) and its phenotypical suppressor (ExbB-A39E) suggested that TonB

218 ry effects of PD-L1 in melanoma cells on TAM phenotypical switching remain underexplored.

219 salt stress conditions improved the desired phenotypical traits of Catharanthus (higher flower numbe

220 Linking genomic variation to phenotypical traits remains a major challenge in evoluti

221 ses of cell growth and division to influence phenotypical traits, observable at the scale of colonies

222 oduce specialized cells that harbor multiple phenotypical traits, thus integrating genetic interindiv

223 This growth phase-dependent phenotypical transition is concomitant with lysis of the

224 Phenotypical variability in the absence of genetic varia

225 c description of the lesions and significant phenotypical variability, there is an impending need for

226 l was trained to dismiss breasts with normal phenotypical variation and to triage lesions (Breast Ima

227 ensitive response both attenuate and amplify phenotypical variations depending on the system's input

228 Phenotypical variations have largely been attributed to

229 hat PPA and frontal lobe dementia constitute phenotypical variations of a unitary disease process wit

230 horts from the literature to determine their phenotypical vulnerabilities and association with AAA ri