ライフサイエンスコーパス: phlebovirus

1 hogenicty in humans infected with this novel phlebovirus.

2 is is the first L protein structure of genus Phlebovirus.

3 r to those of viruses belonging to the genus Phlebovirus.

4 nstitute a single novel species in the genus Phlebovirus.

5 strain entirely from cDNA, the first for any phlebovirus.

6 eins can package genome analogues of related phleboviruses.

7 gnificant advance in the study of tick-borne phleboviruses.

8 groups) and from the mosquito/sandfly-borne phleboviruses.

9 tools to detect these genetically divergent phleboviruses.

10 n our understanding of viral pathogenesis of phleboviruses.

11 IMPORTANCE Rift Valley fever phlebovirus, a bunyavirus, is a mosquito-borne, segmente

12 cribed to date, two new clades of tick-borne phleboviruses, a mononegavirus, and viruses with similar

13 eover, based on the genomic diversity of the phleboviruses and given the low correlation observed bet

14 al and parasitic agents like Bartonella sp., Phleboviruses and Leishmania spp., respectively.

15 mber of the Bunyaviridae virus family (genus Phlebovirus) and is considered to be one of the most imp

16 on as a prioritized pathogen, is an emerging phlebovirus, and fatality rates among those infected wit

17 ated region of a genome segment of a related phlebovirus, and we used virus-like particle assays to a

18 with other recently characterized tick-borne phleboviruses are described using full-length genome seq

19 Evolutionary insights into the phleboviruses are limited because of an imprecise classi

20 s for future research on not only tick-borne phleboviruses but also all viruses and other pathogens t

21 syndrome virus (SFTSV) is a newly discovered Phlebovirus causing an emerging hemorrhagic fever in Eas

22 Our results suggest a rationale for phlebovirus entry in late endosomes.

23 that of nucleoproteins (NPs) from the genus Phlebovirus (family Bunyaviridae), a group of enveloped

24 Many phleboviruses (family Bunyaviridae) are emerging as medi

25 Rift Valley fever virus (RVFV) (genus Phlebovirus, family Bunyaviridae) causes mosquito-borne

26 Rift Valley fever virus (RVFV) (genus Phlebovirus, family Bunyaviridae) has a tripartite negat

27 Rift Valley fever virus (RVFV) (genus Phlebovirus, family Bunyaviridae) has a tripartite negat

28 (RVFV) is a negative-sense RNA virus (genus Phlebovirus, family Bunyaviridae) that infects livestock

29 ver virus (RVFV), which belongs to the genus Phlebovirus, family Bunyaviridae, has a tripartite negat

30 y fever virus (RVFV), belonging to the genus Phlebovirus, family Bunyaviridae, is endemic to sub-Saha

31 Heartland virus is a tickborne phlebovirus first identified in Missouri in 2009; 11 hum

32 h led to the identification of several novel phleboviruses from previously uncharacterized tick-assoc

33 ights into the structure of the encapsidated phlebovirus genome.

34 i virus (UUKV) is a tick-borne member of the Phlebovirus genus (family Bunyaviridae) and has been wid

35 The Phlebovirus genus (family Bunyaviridae) is composed of a

36 t Valley fever virus (RVFV), a member in the Phlebovirus genus of the family Bunyaviridae, is endemic

37 sion protein was discovered in the unrelated phlebovirus genus, and two unexpectedly divergent envelo

38 mmetry and suggest that other members of the Phlebovirus genus, as well as of the Bunyaviridae family

39 TS virus represents a new lineage within the Phlebovirus genus, distinct from the existing sandfly fe

40 tick-borne viruses that are assigned to the Phlebovirus genus.

41 entified the viruses as novel members of the phlebovirus genus.

42 ukuniemi virus, a bunyavirus also within the Phlebovirus genus.

43 osomes, we observed that the conformation of phlebovirus glycoprotein capsomers changes from the nati

44 ever virus (RVFV; family Bunyaviridae, genus Phlebovirus) has a tripartite negative-stranded RNA geno

45 lley fever virus (family Bunyaviridae, genus Phlebovirus) has an antiapoptotic function and affects v

46 FTS virus (SFTSV; family Bunyaviridae, genus Phlebovirus) has caused significant morbidity and mortal

47 Valley fever virus (RVFV), a mosquito-borne phlebovirus, has been detected in Madagascar since 1979,

48 Recently, a number of new tick-borne phleboviruses have been discovered, some of which, like

49 Recently, new tick-borne phleboviruses have emerged, such as severe fever with th

50 These and other phleboviruses have segmented negative-sense RNA genomes

51 ur understanding of how the novel tick-borne phleboviruses hijack cellular machineries to establish i

52 nd functional evidence that the mechanism of phlebovirus-host cell fusion is conserved among genetica

53 s Uukuniemi phlebovirus (UUKV) and Heartland phlebovirus (HRTV).

54 ency as RVFV, while infection with the other phleboviruses-i.e., Punta Toro virus, sandfly fever Sici

55 related highly pathogenic Rift Valley fever phlebovirus in humans and domesticated ungulates.

56 us is a newly recognized member of the genus Phlebovirus in the family Bunyaviridae.

57 the last decade, novel tick-borne pathogenic phleboviruses in the family Bunyaviridae, all closely re

58 ever virus (RVFV, family Bunyaviridae, genus Phlebovirus) is a relevant pathogen of both humans and l

59 ever virus (RVFV; family Bunyaviridae, genus Phlebovirus) is an important emerging pathogen of humans

60 nse member of the family Bunyaviridae, genus Phlebovirus, is the causative agent of Rift Valley fever

61 Phlebovirus L, M, and N mRNAs are synthesized from the v

62 r the N, NSs, and GPC mRNAs in three diverse phleboviruses, namely, Rift Valley fever, sandfly Sicili

63 he main difference between potexvirus CP and phlebovirus NP is in their C-terminal extensions, which

64 ng reporter genes to assess the abilities of Phlebovirus nucleocapsid protein and RNA-dependent RNA p

65 apsid (N) mRNA of Rift Valley fever virus, a phlebovirus of the Bunyaviridae family, also can effecti

66 to vertebrate-infecting viruses in the genus Phlebovirus of the Bunyaviridae.

67 s a model system for investigating the genus Phlebovirus of the Bunyaviridae.

68 The genus Phlebovirus of the family Bunyaviridae consists of appro

69 Valley fever virus (RVFV), belongs to genus Phlebovirus of the family Bunyaviridae, causes high rate

70 Like other members of the genus Phlebovirus of the family Bunyaviridae, TOSV encodes a n

71 es many properties with viruses in the genus Phlebovirus of the family Bunyaviridae.

72 from the genera Bunyavirus, Tospovirus, and Phlebovirus or Nairovirus.

73 is study contributes to our understanding of Phlebovirus pathogenesis and identifies potential target

74 rtonella, Borrelia, Ehrlichia, Coxiella, and Phlebovirus pathogens.

75 aused by the RVF virus (RVFV) (Bunyaviridae: Phlebovirus), presents significant threats to global pub

76 RVFV NSm protein is the first identified Phlebovirus protein that has an antiapoptotic function.

77 Phlebovirus proteins are translated from virally transcr

78 Heartland virus (HRTV) is a tick-borne phlebovirus recently described in Missouri that is assoc

79 a convenient model to investigate aspects of phlebovirus replication.

80 Tick-borne phleboviruses represent a growing threat to humans globa

81 The nonhelical appearance of phlebovirus RNP, the heterogeneous approximately 100-kDa

82 Rift Valley fever phlebovirus (RVFV) has a single-stranded, negative-sense

83 Rift Valley fever phlebovirus (RVFV) is a clinically and economically impo

84 Rift Valley Fever phlebovirus (RVFV) is a mosquito-borne zoonotic pathogen

85 Rift Valley fever phlebovirus (RVFV, Phenuiviridae) is an emerging arbovir

86 ures was found at the ambisense junctions of phlebovirus S RNA segments.

87 ely related to the novel emerging tick-borne phleboviruses severe fever with thrombocytopenia syndrom

88 uses for vaccination studies.IMPORTANCE SFTS phlebovirus (SFTSV) and related tick-borne viruses have

89 SFTS phlebovirus (SFTSV) is an emerging tick-borne bunyavirus

90 fever with thrombocytopenia syndrome (SFTS) phlebovirus (SFTSV) to assess the abilities of viral N a

91 Severe fever with thrombocytopenia syndrome phlebovirus (SFTSV), listed in the most dangerous pathog

92 Severe fever with thrombocytopenia syndrome phlebovirus (SFTSV), listed in the World Health Organiza

93 Akin to other phleboviruses, SFTSV relies on a viral glycoprotein, Gc,

94 om sand flies, we isolated most of the known Phlebovirus strains that potentially cause human infecti

95 SFTSV and related tick-borne phleboviruses such as Heartland virus are emerging virus

96 emergence of two human-pathogenic tick-borne phleboviruses (TBPVs) (severe fever with thrombocytopeni

97 Tick-borne phleboviruses (TBPVs) have been largely neglected until

98 openia syndrome virus (SFTSV) is an emerging phlebovirus that causes a hemorrhagic fever known as the

99 Uukuniemi virus (UUKV) is a tick-borne phlebovirus that is apathogenic for humans and has been

100 l surveillance for other, similar tick-borne phleboviruses that may represent unrecognized causes of

101 In this first L protein structure of genus Phlebovirus, the priming loop of RVFV L protein is disti

102 tle is known about the ability of tick-borne phleboviruses to reassort.

103 Viral RNA elements that control phlebovirus transcriptional terminations are largely unk

104 minimal fusion requirements of a prototypic phlebovirus, Uukuniemi virus, in an in vitro virus-lipos

105 assays for the tick-borne viruses Uukuniemi phlebovirus (UUKV) and Heartland phlebovirus (HRTV).

106 lop a more precise classification system for phleboviruses, we are attempting to sequence most of the

107 (>99% complete) in the genera Nairovirus and Phlebovirus were also identified and found to be present

108 roteins that are conserved among other known phleboviruses were also identified in proteins of the BH

109 ever virus (RVFV; family Bunyaviridae, genus Phlebovirus), which has a tripartite negative-stranded R

110 unyavirales and is the type species of genus Phlebovirus, which accounts for over 50% of family Phenu

111 n completely fulfilled, we believe that this phlebovirus, which is novel in the Americas, is the caus

112 zation Prioritized Pathogens, is an emerging phlebovirus with a high fatality(1-4).

113 fever virus (RVFV) is a member of the genus Phlebovirus within the family Bunyaviridae.