ライフサイエンスコーパス: phosphatase

1 ike protein, protein kinases and purple acid phosphatase.

2 ll immune responses induced by the bacterial phosphatase.

3 common/separate kinases and common/separate phosphatases.

4 ate the activities of regulatory kinases and phosphatases.

5 mily of exoribonucleases, endonucleases, and phosphatases.

6 uccessfully identify previously unknown acid phosphatases.

7 fr-GAP, to describe the three groups of acid phosphatases.

8 tal binding within this family of regulatory phosphatases.

9 S induced the expression of dual specificity phosphatase 1 (DUSP1), activating transcription factor 3

10 r cell migration model, we find that Protein phosphatase 1 (Pp1) activity controls collective cell co

11 pendent protein kinase (PKA) and the protein phosphatase 1 (PP1) and/or PP2A.

12 actin-binding protein that recruits protein phosphatase 1 (PP1) to certain phosphoprotein substrates

13 comitantly, SH2 domain-containing inositol 5-phosphatase 1 (SHIP1) was recruited to the gH/integrin b

14 r through the modulation of dual-specificity phosphatase 1 expression to mediate MAPK activation swit

15 tions in the multiple inositol-polyphosphate phosphatase 1 gene (MINPP1).

16 er cells had increased expression of protein phosphatase 1 regulatory inhibitor subunit 1B (PPP1R1B).

17 as dependent on its interaction with protein phosphatase 1, but not on t-ASPP2-induced YAP activation

18 o loss-of-function (LoF) variants in protein phosphatase 1, regulatory subunit 12a (PPP1R12A), an imp

19 Phosphocholine phosphatase-1 (PHOSPHO1) is a phosphocholine phosphatase

20 nt of a photoreleasable version of a protein phosphatase-1 (PP1)-disrupting peptide (PDP-Nal) that tr

21 Src Homology 2-containing Inositol Phosphatase-1 (SHIP-1) is a target of miR-155, a pro-inf

22 ting peptide (PDP-Nal) that triggers protein phosphatase-1 activity.

23 bnormally increased hepatic protein-tyrosine phosphatase 1B (PTP1B) expression and enhanced PTP1B and

24 Protein-tyrosine phosphatase 1B (PTP1B) is the canonical enzyme for inves

25 Inflammation activates the protein-tyrosine phosphatase 1B (PTP1B), and this could suppress many sig

26 optical approach to control protein tyrosine phosphatase 1B (PTP1B)-an important regulator of recepto

27 The Src homology phosphatase 2 (SHP2) is a cytoplasmic enzyme that mediat

28 Src homology 2 domain-containing phosphatase 2 (SHP2) is an attractive therapeutic target

29 ma subunit of its human host factor, protein phosphatase 2 A.

30 our previous observations that PP2A (protein phosphatase 2) regulates the HIF (hypoxia-inducible fact

31 teins such as cancerous inhibitor of protein phosphatase 2A (CIP2A), protein phosphatase methylestera

32 Protein phosphatase 2A (PP2A) enzymes can suppress tumors, but t

33 The serine/threonine Protein Phosphatase 2A (PP2A) functions as a tumor suppressor by

34 e of the receptor and its associated protein phosphatase 2A (PP2A) in macrophage activation.

35 Protein Phosphatase 2A (PP2A) is a heterotrimer composed of scaf

36 Protein phosphatase 2A (PP2A) is a key signaling component that

37 The tumor suppressor protein phosphatase 2A (PP2A) is a serine/threonine phosphatase

38 uitment of substrates by the ser/thr protein phosphatase 2A (PP2A) is poorly understood, limiting our

39 "targeted chemotherapy" by depleting protein phosphatase 2A (PP2A) or its inhibition using a small mo

40 ify Bbeta2, a mitochondria-localized protein phosphatase 2A (PP2A) regulatory subunit, as a neuron-sp

41 and attenuates protein kinase A and protein phosphatase 2A activities.

42 d of the southern hemisphere against protein phosphatase 2A are described.

43 ough the androgen receptor-STK4/MST1-protein phosphatase 2A axis, which may have important implicatio

44 Furthermore, we noted that protein phosphatase 2A can interact with TET2 and dephosphorylat

45 ignaling, stimulates the activity of protein phosphatase 2A, and thereby attenuates the phospho-Ser-1

46 hat B55beta, a regulatory subunit of protein phosphatase 2A, represents a molecular link between cyto

47 of the serine/threonine phosphatase, protein phosphatase 2A, which operates at the intersection of th

48 (1,5AG6P) caused neutropenia in a glucose-6-phosphatase 3 (G6PC3)-deficient mouse model and in 2 rar

49 Bezafibrate also reduced serum alkaline phosphatase (-35%, P = .03 vs placebo) correlating with

50 tes along chromosomes while ablating Protein Phosphatase 4 had the opposite effect.

51 I(3,4)P(2)-specific inositol polyphosphate 4-phosphatase 4A (INPP4A).

52 f the oncogenic phosphatase protein tyrosine phosphatase 4A3 binds to at least one site on human seru

53 onjunction with the serine/threonine protein phosphatase 5C (PPP5C), inhibits I(SOC) .

54 previously unrecognised class of histidinol-phosphatases; a set of 20 genes required for type IV pil

55 Further, Fig4 is also a protein phosphatase acting on PIKfyve to stimulate its lipid kin

56 tically, this response involves src-homology phosphatase activation leading to Akt-mediated nuclear e

57 Disruption of CovS kinase or phosphatase activities abolishes RocA function, consiste

58 se activity or both PTEN's lipid and protein phosphatase activities.

59 terfaces, we show that D2 inhibits RPTPalpha phosphatase activity and identified a (405)PFTP(408) mot

60 ing (<=5 years) significantly increased soil phosphatase activity by 28%, long-term N loading had no

61 ggesting inhibition of SHP2 protein tyrosine phosphatase activity by this peptide.

62 ent with this finding, inhibition of STRIPAK phosphatase activity causes cell morphology defects in m

63 Its lipid phosphatase activity converts PIP3 to PIP2 and antagoniz

64 Cs in the lesion cap, and increased alkaline phosphatase activity in lesions in the Ahr knockout in c

65 Inhibiting Shp1 phosphatase activity in the absence of Elp1 rescued NGF-

66 is study, we demonstrate that PTEN's protein phosphatase activity is required for epiblast epithelial

67 stabilize beta-catenin while increasing the phosphatase activity of a Ppp2r2c-containing Pp2a comple

68 Phosphatase activity of Siw14 was inhibited by oxidation

69 While the role of PTEN lipid-phosphatase activity on PtdIns(3,4,5)P3 and inhibition o

70 ith PTEN mutants that lack only PTEN's lipid phosphatase activity or both PTEN's lipid and protein ph

71 ed, the biological relevance of PTEN protein-phosphatase activity remains undefined.

72 revealed activation of PKA and inhibition of phosphatase activity thus explaining the increase in pho

73 s, which are rescued by loss of PTEN protein-phosphatase activity to restrain cell survival.

74 genesis, the additional loss of PTEN protein-phosphatase activity triggered an extensive cell death r

75 hosphorylated on IQGAP1 when phosphotyrosine phosphatase activity was inhibited in cells.

76 Assessment of kinase and phosphatase activity within the myofilament fraction of

77 tion (activation) by regulating PTPN6 (Shp1) phosphatase activity within the signaling complex.

78 /-), which is associated with an impaired 5'-phosphatase activity, also leads to Parkinson's disease

79 The PTEN-like domain has no phosphatase activity, but it can recognize phosphatidyli

80 ab7, a recently identified substrate of PTEN phosphatase activity, is also a substrate of the innate

81 idative stress response through its NADPH 2' phosphatase activity.

82 ded differential phosphorylation of kinases, phosphatases, adaptor proteins, transcription factors su

83 entiation, whereas the expression of alkalin phosphatase (ALP) and collagen A I (COL I) genes was ana

84 in gamma-glutamyltransferase (GGT), alkaline phosphatase (ALP) and total bilirubin are also reported,

85 does not increase the diffusion of alkaline phosphatase (ALP) at the single-molecule level, in sharp

86 Alkaline phosphatase (ALP) is an important biomarker, as high lev

87 mone (PTH), calcium, phosphorus and alkaline phosphatase (ALP) values were measured at a series of ti

88 n functions, an enzymatic reaction (alkaline phosphatase, ALP) and a ligand-protein (carbonic anhydra

89 Receptor-type protein tyrosine phosphatase alpha (RPTPalpha) is an important positive r

90 Glucose-6-phosphatase-alpha (G6Pase-alpha or G6PC) deficiency in g

91 acological inhibition of the age-upregulated phosphatase ALPL, a predicted negative regulator of tran

92 STEP is a protein tyrosine phosphatase (also known as PTPN5), with several isoforms

93 This mechanical transition required PP2A phosphatase and correlated with inactivation of PLK-1 (P

94 286) is a peptide fragment of prostatic acid phosphatase and has been reported to form amyloid fibril

95 the trophoblast proteins placental alkaline phosphatase and HLA-G.

96 ration, we identify the Striatin-interacting phosphatase and kinase (STRIPAK) complex as a potent neg

97 t are components of the Striatin-interacting phosphatase and kinase (STRIPAK) complex.

98 is a new member of the striatin-interacting phosphatase and kinase complex (STRIPAK).

99 equency of tumor protein p53 (Tp53/p53)- and phosphatase and tensin homolog (PTEN) deficiencies, and

100 Expression of the phosphatase and tensin homolog (PTEN), which is one of t

101 We identify disinhibition of phosphatase and tensin homolog deleted on chromosome 10

102 Phosphatase and tensin homolog located on chromosome 10

103 with germline mutations in the gene encoding phosphatase and tensin homolog on chromosome ten (PTEN)

104 hile the loss of the tumor suppressor, PTEN (phosphatase and tensin homolog), is well studied in endo

105 in kidney cancer, for example, by targeting phosphatase and tensin homologue (PTEN) for proteasomal

106 e been described in patients with pathogenic phosphatase and tensin homologue (PTEN) variants, but th

107 In orthotopic phosphatase and tensin homologue (PTEN)-deficient glioma

108 Tumor suppressor PTEN (phosphatase and tensin homologue deleted on chromosome 1

109 tically, we found that RGS12 associated with phosphatase and tension homolog (PTEN) via the PDZ domai

110 related to the other types, (2) class C acid phosphatases and (3) generic acid phosphatases (GAP).

111 of PYR/PYL/RCAR ABA receptors, PP2C protein phosphatases and SnRK2 protein kinases has led to studie

112 fly lines with a focus on targeting kinases, phosphatases and transcription factors, each expressing

113 ferase, aspartate aminotransferase, alkaline phosphatase, and gamma-glutamyl transferase: - 27.2, - 7

114 of adhesion molecules and tumor suppressing phosphatases, and alteration in immune modulators.

115 ble fragment of antibody fused with alkaline phosphatase (anti-IC-HT2 scFv-ALP) which is able to prod

116 knock-in reporter allele expressing alkaline phosphatase (AP) and intersectional genetics had identif

117 in utilizing ATP is not related to alkaline phosphatase (AP), an important DOP hydrolase, although e

118 mbers of the PP2A family of serine/threonine phosphatases are important human tumor suppressor genes.

119 Both kinase and phosphatases are sensitive to intramolecular disulfide f

120 tor (NF)-kappaB utilizes the PPM1G/PP2Cgamma phosphatase as a coactivator to normally induce inflamma

121 Active PI3Kalpha and its associated kinases/phosphatases assemble at membrane regions enriched in si

122 ate with STRIPAK, but the functions of these phosphatase-associated kinases remain elusive.

123 tic targeting, and aid in the development of phosphatase-based therapeutics tailored against disease

124 their principal role in the SAC because both phosphatases become redundant if PLK1 is inhibited or BU

125 r 2 and 4 weeks had decreased serum alkaline phosphatase but increased serum transaminases compared w

126 , we show that the calcium-activated protein phosphatase calcineurin dephosphorylates Hoxb13 at serin

127 The ubiquitous Ca(2+) /calmodulin-dependent phosphatase calcineurin is a key regulator of pathologic

128 activity of the Ca(2+)/calmodulin-dependent phosphatase calcineurin toward nuclear factor of activat

129 g the molecular chaperone Hsp90, the protein phosphatase calcineurin, and the small GTPase Ras1, as w

130 been shown previously that in the absence of phosphatase, CaMKII monomers integrate over Ca2+ signals

131 of metabolism caused by defective glucose-6-phosphatase catalytic subunit (G6PC) activity.

132 Soil extracellular phosphatases catalyze the hydrolysis of P from soil orga

133 The phosphatase CD45 is more strongly excluded from bilayer-

134 ation motifs to the promiscuous cell-surface phosphatase CD45(2,3), which results in the direct intra

135 protein Net1, altering its affinity for the phosphatase Cdc14, whose activity is essential for mitot

136 We demonstrate that the NE protein phosphatase, CNEP-1/CTDNEP1, controls de novo glycerolip

137 underline a unique role of the B55alpha/PP2A phosphatase complex in vessel remodeling and suggest the

138 4-1BB-encoding CAR recruits the THEMIS-SHP1 phosphatase complex that attenuates CAR-CD3zeta phosphor

139 -inducible protein 34), a subunit of the PP1 phosphatase complex that promotes the dephosphorylation

140 Kinases and phosphatases, correlated with tau phosphorylation were a

141 , aspartate aminotransferase (AST), alkaline phosphatase, creatinine, and improved liver, and renal a

142 d by reexpression of active PPM1F, but not a phosphatase-dead mutant.

143 eterologous expression of wild-type, but not phosphatase-deficient, OCRL prevented the accumulation o

144 We also found that the Pp1-87B phosphatase dephosphorylates moesin, counteracting its a

145 omeres inactivates Aurora B kinase, and PP2A phosphatase dephosphorylates the kinetochore proteins to

146 nlikely to be an active sulfurtransferase or phosphatase, despite containing a putative catalytic sit

147 ivating mutation (R258Q) in the Sac inositol phosphatase domain of synaptojanin 1 (SJ1/PARK20), a pho

148 re, we report the crystal structure of the 5-phosphatase domain of Synj1.

149 omology 3 domain, and a C-terminal histidine phosphatase domain.

150 tions between its N-SH2 and protein-tyrosine phosphatase domains are weakened such that SHP2/T507K po

151 e human mutations were identified in the two phosphatase domains of SYNJ1, including R258Q, R459P and

152 lar receptor domain and tandem intracellular phosphatase domains: comprising an active membrane proxi

153 Balanced activity of kinases and phosphatases downstream of the BCR is essential for B ce

154 onal null allele of inositol polyphosphate-5-phosphatase E (Inpp5e), ridge top (rdg), with expanded v

155 conserved with the endonuclease/exonuclease/phosphatase (EEP) domain-containing CCR4 family of deade

156 oinositide phosphatase with dual SAC1 and 5'-phosphatase enzymatic activities in regulating phospholi

157 hat the PAS domain regulates both kinase and phosphatase enzyme activity of SrrB and present the stru

158 in vivo levels are regulated by SAL1/FRY1, a phosphatase enzyme located in chloroplast and mitochondr

159 tivation, which is thought to involve steric phosphatase exclusion as well as direct mechanical force

160 incorporates both ordered domains and direct phosphatase exclusion mechanisms to produce a more sensi

161 reen for mutations that de-repress Pho1 acid phosphatase expression in CTD-T4A cells.

162 Regulatory genes encoding kinases/phosphatases/F-box proteins and transcription factors fo

163 nerating PI(3,5)P(2) from PI3P and the lipid phosphatase Fig4, reversing the reaction.

164 ine phosphorylation by competing with active phosphatases for the binding of substrates.

165 ability of the receptor to prevent alkaline phosphatase from hydrolysing these substrates.

166 lts, we cloned genes encoding candidate acid phosphatases from genomic DNA or recovered from metageno

167 ns, we show that although loss of PTEN lipid-phosphatase function cooperates with oncogenic PI3K to p

168 This suggests that independent of its lipid phosphatase function, the active site plays a role in th

169 ass C acid phosphatases and (3) generic acid phosphatases (GAP).

170 labeling and whole-mount placental alkaline phosphatase histochemistry, we found that itch-sensing s

171 by histomorphometry, tartrate-resistant acid phosphatase histoenzymology, beta-galactosidase, scleros

172 phosphatases (MINPPs) are clade 2 histidine phosphatases (HP2P) able to carry out the stepwise hydro

173 Intestinal alkaline phosphatase (IAP) regulates bicarbonate secretion, detox

174 aptojanin 1 (SJ1/PARK20), a phosphoinositide phosphatase implicated in synaptic vesicle recycling, re

175 Synaptojanin1 (Synj1) is a phosphoinositide phosphatase, important in clathrin uncoating during endo

176 ould reveal new strategies for targeting the phosphatase in disease.

177 supports an involvement of activated protein phosphatase in executing the dephosphorylation downstrea

178 osphoinositol pentakisphosphate (PP-InsP(5)) phosphatase in Saccharomyces cerevisiae encoded by SIW14

179 novel role of PTPRF as an oncogenic protein phosphatase in supporting the activation of Wnt signalin

180 PTP-3/LAR PTPR, we speculate a role of this phosphatase in SYD-2-mediated motor activation.

181 Fig4 is active as a lipid phosphatase in the ternary complex, whereas PIKfyve with

182 rived from these mice to explore the role of phosphatases in CLL.

183 sent a systematic functional analysis of the phosphatases in Cryptococcus neoformans, a fungal pathog

184 ific calcineurin (PP2B), a calcium regulated phosphatase, in testis and sperm, are also infertile.

185 totic proteins, because of parallel PP2A:B55 phosphatase inactivation by Greatwall kinase.

186 n human CLL, we found overexpression of many phosphatases including SHIP2.

187 f regenerating liver) 2 and cancer, how this phosphatase induces oncogenesis has been an enigma.

188 duction and the ciliary phosphatidylinositol phosphatase Inpp5e is linked to Shh regulation.

189 ve option for other proline-serine-threonine phosphatase-interacting protein 1-associated inflammator

190 Proline-serine-threonine phosphatase-interacting protein 1-associated myeloid-rel

191 nse mutation in the proline-serine-threonine phosphatase-interacting protein 2 (Pstpip2) gene.

192 ionality of PP2A-B'gamma to a protein kinase-phosphatase interaction with the defense-associated calc

193 odels indicate roles in pathogenicity for 31 phosphatases involved in various processes such as therm

194 s through the receptor-type tyrosine-protein phosphatases kappa led to acquisition of a full mesenchy

195 isease caused by the absence of the glycogen phosphatase laforin or its interacting partner malin, de

196 LAR-type receptor phosphotyrosine-phosphatases (LAR-RPTPs) are presynaptic adhesion molecu

197 and is characterized by high serum alkaline phosphatase level, often with normal or only slightly ab

198 phosphorylated AGC kinases are sensitive to phosphatase-mediated dephosphorylation, the PKAc activat

199 nals induce Syk activation followed by rapid phosphatase-mediated desensitization; however, how degra

200 r of protein phosphatase 2A (CIP2A), protein phosphatase methylesterase 1 (PME-1), and SET nuclear pr

201 Multiple inositol polyphosphate phosphatases (MINPPs) are clade 2 histidine phosphatases

202 the monomeric subunits were affected in the phosphatase mutants.

203 binding to MKP3, a dual-specificity protein phosphatase negatively regulating ERK function.

204 The hematopoietic-specific protein tyrosine phosphatase nonreceptor type 22 (PTPN22) is encoded by a

205 r nephrin (NPHS1) and receptor-type tyrosine-phosphatase O (PTPRO).

206 of mitosis and ensures that release of Cdc14 phosphatase occurs only after completion of key mitotic

207 a compelling connection exists between PRL (phosphatase of regenerating liver) 2 and cancer, how thi

208 or atypical gyration encoded regions of the phosphatase or C2 domains of PTEN.

209 Here we identify phosphatase orphan 1 (Phospho1) as a new player in myoge

210 ne reduced nicotinamide adenine dinucleotide phosphatase oxidase (NADPH oxidase) levels, in compariso

211 X2 (NADPH [nicotinamide adenine dinucleotide phosphatase] oxidase subunit 2) and NOX4 (NADPH [nicotin

212 X4 (NADPH [nicotinamide adenine dinucleotide phosphatase] oxidase subunit 4) were upregulated.

213 Lipin/Pah phosphatidic acid phosphatases (PAPs) generate diacylglycerol to regulate

214 expression levels of pyruvate dehydrogenase phosphatase (PDP) and pyruvate dehydrogenase (PDH), dram

215 We show that deletion of mitochondrial phosphatase PGAM5 leads to accelerated retinal pigment e

216 four of these measures: hemoglobin, alkaline phosphatase, platelets, and lymphocytes.

217 Cdc14 protein phosphatases play an important role in plant infection b

218 sing cells abrogate polynucleotide kinase 3'-phosphatase (PNKP) activity.

219 for the abundance of Tartrate Resistant Acid Phosphatase-positive osteoclasts, which revealed that mu

220 n the levels of the serine/threonine-protein phosphatase PP1-alpha catalytic subunit or protein kinas

221 elieves inhibition of the CDK1-counteracting phosphatases PP1 and PP2A-B55, allowing wide-spread deph

222 amily of regulatory subunits of key cellular phosphatase PP2A (PPP2R5A-E; Greenwood et al., 2016; Naa

223 ical Hippo signaling and supports a role for phosphatase PP2A, but also suggests Sav1 has functions i

224 nine residue on the catalytic subunit of the phosphatase PP2A, which disrupted its holoenzyme formati

225 vis egg extracts that the Cdk1-counteracting phosphatase PP2A-B55 functions as a bistable switch, eve

226 in the regulation of the Cdk1-counteracting phosphatase PP2A-B55.

227 is counteracted by the main cardiac protein phosphatases, PP2A and PP1.

228 biquitinates the Arabidopsis clade A type 2C phosphatases (PP2Cs) ABI/HAB group and AHG3, thus trigge

229 ABA-triggered inhibition of type-2C protein-phosphatases (PP2Cs).

230 A genetic screen identifies the phosphatase PPM1F as the critical enzyme, which selectiv

231 ss small molecule inhibitor of the oncogenic phosphatase protein tyrosine phosphatase 4A3 binds to at

232 o1 enhanced activity of the serine/threonine phosphatase, protein phosphatase 2A, which operates at t

233 transitions in C. reinhardtii mutants of two phosphatases, PROTEIN PHOSPHATASE1 and PHOTOSYSTEM II PH

234 ial targeting of protein kinases and protein phosphatases provides a means to locally control the pho

235 accompanied by loss of the tumor-suppressing phosphatase PTEN.

236 mutations and asked whether activation of a phosphatase PTP1B participates in the disease process.

237 The novel protein tyrosine phosphatase PTPN14 was identified by mass spectrometry a

238 Recombinant alkaline phosphatase (recAP) deactivates LPS.

239 entify the tumor suppressor Protein tyrosine phosphatase receptor-type kappa (PTPRK), as a Wnt inhibi

240 or signalling, termed receptor inhibition by phosphatase recruitment (RIPR).

241 Protein tyrosine phosphatases regulate a myriad of essential subcellular

242 Local phosphatase regulation is needed at kinetochores to sile

243 t miRNA site counts, along with ANKRD52, the phosphatase regulatory subunit of the recently identifie

244 the dephosphory-lation of Pah1 phosphatidate phosphatase, required for its translocation to the nucle

245 hat this tripartite cooperative mechanism of phosphatase resistance is functionally relevant, as demo

246 This cooperative mechanism of phosphatase resistance of AGC kinase opens new perspecti

247 rminal FXXW motif to cooperatively establish phosphatase resistance of PKAc while not affecting kinas

248 ons and metabolic demands, but counteracting phosphatase(s) remain unknown in C. reinhardtii Here we

249 A kinase and phosphatase screen for activators of translation, based

250 ter to express a secreted embryonic alkaline phosphatase (SEAP) reporter.

251 Ac N and C termini coordinately regulate the phosphatase sensitivity of this enzyme.

252 ncy led to reduced levels of active tyrosine phosphatase SHP1, which plays a B cell-intrinsic provira

253 The protein tyrosine phosphatase SHP2 binds to phosphorylated signaling motif

254 The tyrosine phosphatase SHP2 controls the activity of pivotal signal

255 The protein-tyrosine phosphatase SHP2 is an allosteric enzyme critical for ce

256 vation (such as by targeting the scaffolding phosphatase SHP2).

257 ilable, an inhibitor of the protein tyrosine phosphatase SHP2, a critical mediator of RAS signal tran

258 The protein tyrosine phosphatase SHP2, encoded by PTPN11, is ubiquitously exp

259 Protein tyrosine phosphatase sigma (PTPsigma, PTPRS), a receptor for PNNs

260 ine or ATPgammaS downstream effector, myosin phosphatase, significantly attenuated the E. coli-induce

261 activity, PTPRU binds substrates of related phosphatases strongly suggesting that this pseudophospha

262 PPP-family phosphatases such as PP1 have little intrinsic specifici

263 aN) revealed that it belongs to the alkaline phosphatase superfamily, contains a Zn(2+) ion at its ac

264 pharmacologically by activation of the PP2A phosphatase, suppresses SCLC expansion in culture and in

265 Here, we define two kinase-phosphatase switches that operate at different points in

266 dentified DUSP8, encoding a dual-specificity phosphatase targeting mitogen-activated protein kinases,

267 bind the same PPP2R5 surface as physiologic phosphatase targets.

268 T-cell protein tyrosine phosphatase (TC-PTP), encoded by Ptpn2, has been shown t

269 yeast Saccharomyces cerevisiae is a protein phosphatase that catalyzes the dephosphory-lation of Pah

270 phosphatase-1 (PHOSPHO1) is a phosphocholine phosphatase that catalyzes the hydrolysis of phosphochol

271 2A results in activation of PP2A-B55alpha, a phosphatase that dephosphorylates the WEE1 protein and r

272 PGAM5 is a mitochondrial serine/threonine phosphatase that regulates multiple metabolic pathways a

273 , but small-molecule activators of PP2A, the phosphatase that regulates MYC Ser62 phosphorylation, ci

274 GF signaling by blocking the activity of its phosphatase that shuts off those signals.

275 to how cells and viruses use a conserved RNA phosphatase to regulate and respond to ppp-RNA species.

276 ugh this, cells conditionally modify a major phosphatase to stabilize a metabolic master regulator an

277 uxin Up RNA (SAUR) proteins regulate protein phosphatases to control H(+)-ATPase activity.

278 ac myocytes induced translocation of PKA and phosphatases to the myofilament compartment as shown by

279 ecific Pol II carboxyl terminal domain (CTD) phosphatase, to form the BAH-PHD-CPL2 complex (BPC) for

280 Phosphatases, together with kinases and transcription fa

281 of cells stained for tartrate-resistant acid phosphatase (TRAP) and immunohistochemical staining for

282 anes as indicated by tartrate-resistant acid phosphatase (TRAP) staining and pit formation.

283 er was determined by tartrate-resistant acid phosphatase (TRAP) staining.

284 teocalcin [OCN], and tartrate-resistant acid phosphatase [TRAP]) analyses were performed.

285 e host cellular nonreceptor protein tyrosine phosphatase type 14 (PTPN14) and direct it for degradati

286 r tumor suppressor, inositol-polyphosphate 4-phosphatase type II (INPP4B), can partially compensate f

287 ature-tagged mutant strains for 114 putative phosphatases under 30 distinct in vitro growth condition

288 Systemic inhibition of this phosphatase using a selective inhibitor prevented cognit

289 ic IN assembly bound to two molecules of the phosphatase via a conserved short linear motif.

290 chanistically, PP2A-Cdc55 ceramide-activated phosphatase was found to act downstream of Isc1, thus co

291 s of more than 4000 annotated bacterial acid phosphatases was carried out.

292 The exclusion of large receptor-type phosphatases was observed on the soft bilayers, however,

293 ses, PROTEIN PHOSPHATASE1 and PHOTOSYSTEM II PHOSPHATASE, which are homologous to proteins that antag

294 the following three types: (1) class B acid phosphatases, which were distantly related to the other

295 slightly decreased levels of serum alkaline phosphatase, while eight do not.

296 evolved mutations to naturally function as a phosphatase whose activity is influenced by exogenous bu

297 phosphatase 2A (PP2A) is a serine/threonine phosphatase whose activity is inhibited in most human ca

298 3,4,5)P(3), providing the first image of a 5-phosphatase with a trapped substrate in its active site.

299 Synaptojanin1 (synj1) is a phosphoinositide phosphatase with dual SAC1 and 5'-phosphatase enzymatic

300 onstrate a role of receptor protein tyrosine phosphatase zeta (RPTPzeta) in PNN structure.