ライフサイエンスコーパス: phosphatidic acid

1 through MGDG SYNTHASE1 (MGD1) activation by phosphatidic acid.

2 diacylglycerol that can be phosphorylated to phosphatidic acid.

3 ne to generate an important signaling lipid, phosphatidic acid.

4 apping protein (CP) by the signalling lipid, phosphatidic acid.

5 anslocates to ER-PM junctions via binding to phosphatidic acid.

6 age sensor regulation by the signaling lipid phosphatidic acid.

7 d controlled, we characterize two effects of phosphatidic acid.

8 oss of function and, as expected, accumulate phosphatidic acid.

9 wn to be lipid-binding proteins specific for phosphatidic acid.

10 competing with the endogenous mTOR activator phosphatidic acid.

11 kinase that phosphorylates diacylglycerol to phosphatidic acid.

12 receptor gamma (PPARgamma) inhibitor cyclic phosphatidic acid.

13 talyzes the formation of diacylglycerol from phosphatidic acid.

14 Here we show that Epac1 binds directly to phosphatidic acid.

15 shes translocation, also prevents binding to phosphatidic acid.

16 veral APLs, including phosphatidylserine and phosphatidic acid.

17 in fibronectin and the membrane phospholipid phosphatidic acid.

18 , and has a specific requirement for dietary phosphatidic acid.

19 ucial compound hijacked by T. ratisbonensis: phosphatidic acid.

20 Diacylglycerol kinase (DGK) converts DG into phosphatidic acid.

21 ds phosphatidylinositol 4,5-bisphosphate and phosphatidic acid.

22 g of the DEP1 domain to liposomes containing phosphatidic acid.

23 a were dominated by phosphatidylcholines and phosphatidic acids.

24 18:1, alkylglycerophosphate 18:1, and cyclic phosphatidic acid 18:1, all with a monounsaturated C18 h

25 Lyso-phosphatidic acid-18:2 (LPA-18:2) was the only lipid wit

26 GAC PH domain also binds to phosphatidic acid, a lipid mediator associated with micr

27 -, di-, and triphosphorylated inositides), a phosphatidic acid, a phosphatidylcholine, a phosphatidyl

28 Intracellular phosphatidic acid accounts for a nearly 50 mV shift in t

29 Lipin 2/3 deficiency caused phosphatidic acid accumulation and mammalian target of r

30 We hypothesize this to be a result of phosphatidic acid accumulation in the chloroplast outer

31 uter leaflet of the outer envelope membrane, phosphatidic acid accumulation is not observed, likely b

32 ged lipid, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphatidic acid acid (POPA), in supported lipid bilaye

33 The product of PLD, phosphatidic acid, activates the enhancer in a rapamycin

34 cial for TRE biogenesis is the generation of phosphatidic acid, an essential lipid component of TRE t

35 Ubiquitination hinders Dvl binding to phosphatidic acid, an interaction necessary for efficien

36 a sperm phospholipase D activity to produce phosphatidic acid and boosts the synthesis of phosphatid

37 headgroup of phosphatidylcholine to produce phosphatidic acid and choline.

38 eporters of PI(4,5)P(2) and PI4P, as well as phosphatidic acid and diacylglycerol and used them to mo

39 plicating a variety of other lipids, such as phosphatidic acid and diacylglycerol, and their metaboli

40 of long chain CoAs and de novo generation of phosphatidic acid and diacylglycerol.

41 basic amino acids lysine and histidine, and phosphatidic acid and phosphatidylglycerol are the least

42 this process in vitro and found that mainly phosphatidic acid and phosphatidylinositol-4-phosphate e

43 xes, which exert lipid transfer activity for phosphatidic acid and phosphatidylserine, respectively.

44 ly with a number of phospholipids, including phosphatidic acid and phosphoinositol(3,4,5)P3, phosphoi

45 ast membranes and specific interactions with phosphatidic acid and phosphorylated forms of phosphatid

46 tein is able to bind to liposomes containing phosphatidic acid and protect the liposomes from fusing

47 de, and phosphatidylethanolamine inhibit and phosphatidic acid and sphingomyelin enhance SPCA1a activ

48 ecrosis and regeneration and accumulation of phosphatidic acid and, paradoxically, diacylglycerol.

49 A semi-quantitative analysis indicated phosphatidic acids and phosphatidylglycerols as the most

50 served in obesity (e.g. free fatty acids and phosphatidic acid) and plastics exposure (monophthalate

51 nces were observed for phosphatidylinositol, phosphatidic acid, and bis(monoacylglycero)phosphate spe

52 sting of palmitoylsphingomyelin, dimyristoyl phosphatidic acid, and cholesterol in three different pr

53 s include phosphoinositides, diacylglycerol, phosphatidic acid, and cholesterol/ergosterol.

54 ctions of its enzymatic product of reaction, phosphatidic acid, and its unique shape-binding role on

55 PC, PC-derived diacylglycerol, phosphatidic acid, and lyso-phosphatidylcholine (LPC) ha

56 -bilayer-forming lipids such as cardiolipin, phosphatidic acid, and phosphatidylethanolamine (PE) are

57 ylserine, phosphatidylglycerol, cardiolipin, phosphatidic acid, and phosphorylated derivatives of pho

58 6K1 preferentially bound to the phospholipid phosphatidic acid, and this binding was required for IP6

59 s cardiolipin, phosphatidylethanolamine, and phosphatidic acid are present in the yeast bc(1) complex

60 Phosphoinositides and phosphatidic acid are small anionic lipids that comprise

61 Phosphatidic acid, as synthesized by phospholipase D (PL

62 pport the conclusion that a specific pool of phosphatidic acid, associated with lipid droplet formati

63 ifferent ionic strengths, and for dioctanoyl phosphatidic acid at different pH values.

64 ctly competes for the endogenous PLD product phosphatidic acid at lipid-binding sites within potassiu

65 1 led to its activation and the synthesis of phosphatidic acid at sites of neurite growth.

66 favors Opi1p interaction with both Scs2p and phosphatidic acid at the endoplasmic reticulum (ER) memb

67 nd highlight a potential role of Dgkzeta-DAG/phosphatidic acid axis as a modulator of inflammatory cy

68 erolpyrophosphate, ceramide-1-phosphate, and phosphatidic acid belong to a unique class of membrane s

69 With distinct phosphatidic acid binding abilities and PI transfer prot

70 We further studied phosphatidic acid binding by MAM7 using site-directed mu

71 Mutating residues implicated in phosphatidic acid binding revealed a possible role in Ba

72 Finally, we showed that fibronectin and phosphatidic acid binding to MAM7 are not mutually exclu

73 Using a newly developed PA biosensor, PASS (phosphatidic acid biosensor with superior sensitivity),

74 ion-mode of phosphoinositide phosphates and phosphatidic acid bound to {LGa2}(5+) were between 2.5-

75 We also found that a lipid second messenger, phosphatidic acid, bound PTPD2 in vitro and enhanced its

76 wild type, including increased abundance of phosphatidic acids but reduced abundance of diglycerides

77 and potently disrupts liposomes composed of phosphatidic acid by forming pores.

78 Furthermore, depletion of phosphatidic acid by inhibition of phospholipase D1 prev

79 Apart from this function, exogenous phosphatidic acid by itself (300 pM) increases GTP bindi

80 rometry (LC-MS) to show that accumulation of phosphatidic acid by means other than cdsA mutations als

81 hanolamine) and anionic (phosphatidylserine, phosphatidic acid, cardiolipin, and phosphatidylinositol

82 , phosphatidylserines, phosphatidylglycerol, phosphatidic acids, ceramide phosphates, sterol lipids,

83 We suggest that increased levels of phosphatidic acid change the physical properties of the

84 phosphatidylcholine, phosphatidylserine, and phosphatidic acid classes.

85 a distinct architecture, specifically binds phosphatidic acid commonly present within the inner leaf

86 phatidylserine, sphingosine 1-phosphate, and phosphatidic acid, could not elicit the potent chemotact

87 Here we show that increased phosphatidic acid derived from Phospholipase D leads to

88 The phosphomonoester headgroup of phosphatidic acid enables this lipid to act as a pH bios

89 We also found that phosphatidic acid enhances Fes activity in MDA-MB-231 ce

90 ental evidence for the mitotic regulation of phosphatidic acid flux and suggest that the regulatory n

91 n for blood-brain barrier targeting and with phosphatidic acid for Abeta binding.

92 acyl-ACP to acyl-phosphate on the pathway to phosphatidic acid formation.

93 interaction is required for the transfer of phosphatidic acid from the ER to the mitochondria for ca

94 Phosphatidic acid generated by PLD2 promotes the plasma

95 rolmonoalkyl glycerol tetraether lipids with phosphatidic acid headgroups (GMGTPA) occur without lipo

96 act with the negatively charged phospholipid phosphatidic acid immobilized on solid substrates or in

97 produce phosphatidic acid-reveal a role for phosphatidic acid in Bazooka embryonic epithelial activi

98 ospholipase D (PLD), an enzyme that produces phosphatidic acid in cells, also attenuated the ERBB2 ph

99 Overall our results highlight a new role for phosphatidic acid in endocytic recycling and provide new

100 he first enzyme in the pathway that produces phosphatidic acid in Gram-positive bacteria.

101 Indeed, the presence of phosphatidic acid in liposomes enhances the ability of s

102 f the involvement of phospholipase D-derived phosphatidic acid in regulated exocytosis, we used an ar

103 o acyl chain discrimination among species of phosphatidic acid in the activation of the phosphorylati

104 lipase D and its biologically active product phosphatidic acid in the late, Ca(2+)-triggered steps of

105 he inner membrane and its C terminus binding phosphatidic acid in the outer membrane.

106 TP-dependent conversion of diacylglycerol to phosphatidic acid in the plasma membrane of Escherichia

107 otene when expressed in Escherichia coli and phosphatidic acid in vitro.

108 acted specifically with liposomes containing phosphatidic acid in vitro.

109 which CP activity is negatively regulated by phosphatidic acid in vivo.

110 (DGK), which phosphorylates DAG to generate phosphatidic acid, in the regulation of pigmentation.

111 ized membrane lipid species and normal-chain phosphatidic acids indicated that stress-induced ox-lipi

112 Phosphatidic acid interacts with Lsi6, a silicon transpo

113 which encodes a phospholipase that catalyzes phosphatidic acid into lysophosphatidic acid and free fa

114 We propose that phosphatidic acid is a limiting precursor for the synthe

115 Phosphatidic acid is a putative second messenger implica

116 Activation of PIP5K by phosphatidic acid is also acyl chain-dependent.

117 Phosphatidic acid is typically synthesized in a three-st

118 Senescence induced by its product, phosphatidic acid, leads to a senescence-associated secr

119 PLD2 overexpression-->PLD2/Fes association-->phosphatidic acid-led activation of Fes kinase-->granulo

120 Dgk) zeta, an enzyme which converts DAG into phosphatidic acid, limits inflammatory cytokine producti

121 AGPAT2 modulated the levels of phosphatidic acid, lysophosphatidic acid, phosphatidylin

122 nt of individual fatty acyl substituents and phosphatidic acid moieties.

123 on from complex phospholipids to more simple phosphatidic acid molecules systematically occurred.

124 at both the substrate (LPA) and the product (phosphatidic acid) of the LPA acyltransferase reaction a

125 hroism and electron microscopy, we show that phosphatidic acid, oleic acid, and the phthalate metabol

126 tudy uncovers and investigates the effect of phosphatidic acid on Kv channel gating.

127 of phospholipase D activity and its product phosphatidic acid on the Ca(2+) sensitivity and rate of

128 ycerides and found that 1-palmitoyl-2-oleoyl-phosphatidic acid or 1-palmitoyl-2-oleoyl-phosphatidylgl

129 tivity is elevated with PLD2 overexpression, phosphatidic acid or phosphatidylinositol bisphosphate.

130 zeta binds significantly to PIP2, but not to phosphatidic acid or phosphatidylserine, and that sequen

131 ipids with phosphate headgroups, namely C1P, phosphatidic acid or their lyso-derivatives, remains unc

132 However, in the presence of phosphatidic acid, or of cardiolipin, interaction is det

133 horylating substrates lysophosphatidic acid, phosphatidic acid, or sphingosine-1-phosphate but surpri

134 While the precursors for phosphatidic acid (PA) (long-chain fatty acyl-CoAs and l

135 s phosphatidylinositol phosphates (PIPs) and phosphatidic acid (PA) and acts as a phosphatidylinosito

136 CpGRP1 can also bind phosphatidic acid (PA) and cardiolipin.

137 her plants often induces rapid production of phosphatidic acid (PA) and changes in lipid profiles, bu

138 Phosphatidic acid (PA) and diacylglycerol (DAG) have bee

139 chemical assay for lipin 1 using mixtures of phosphatidic acid (PA) and phosphatidylethanolamine that

140 nteracts with the lysosomal signaling lipids phosphatidic acid (PA) and phosphatidylinositol(3,5)bisp

141 Phosphatidic acid (PA) and phytosphingosine 1-phosphate

142 Phosphatidic acid (PA) and the conserved integral ER mem

143 Drp1 recognizes the head group of phosphatidic acid (PA) and two saturated acyl chains of

144 ane surface to resemble apoptotic bodies and phosphatidic acid (PA) at the inner layer as a strategy

145 PLD) activity and triggers the production of phosphatidic acid (PA) at the plasma membrane of macroph

146 of lipins 1 and 2 and shown that di-anionic phosphatidic acid (PA) augments their activity and lipid

147 We previously found that phosphatidic acid (PA) binds Sec18 and thereby sequester

148 rprisingly, however, nanobilayers containing phosphatidic acid (PA) bound substantially more of two o

149 se, besides PI, RdgBbeta binds and transfers phosphatidic acid (PA) but hardly binds phosphatidylchol

150 Here we show that insulin signaling elevates phosphatidic acid (PA) dramatically on LDs in the fed st

151 One regulator of the Ras-ERK cascade is phosphatidic acid (PA) generated by phospholipase D (PLD

152 Phosphatidic acid (PA) has emerged as a class of cellula

153 rizzled receptor and the plasma membrane via phosphatidic acid (PA) in a mechanism proposed to be pH-

154 Here we analyzed a potential role of phosphatidic acid (PA) in biogenesis of mitochondrial pr

155 In this study we examined the role of phosphatidic acid (PA) in hepatic glucose production (HG

156 NDGD1 binds to phosphatidic acid (PA) in membranes and mediates PA-depe

157 ent of phospholipase D (PLD) and its product phosphatidic acid (PA) in podosome formation, but the sp

158 nt phosphorylation of diacylglycerol to form phosphatidic acid (PA) in the phosphatidylinositol cycle

159 ture dendritic cells have elevated levels of phosphatidic acid (PA) in their plasma membrane.

160 nd -4-phosphate, and phosphatidylglycerol to phosphatidic acid (PA) in vitro.

161 l glycerolipid metabolite and lipid mediator phosphatidic acid (PA) interacts with and modulates the

162 Phosphatidic acid (PA) interacts with the FK506-binding

163 Phosphatidic acid (PA) is a central precursor for membra

164 Phosphatidic acid (PA) is a class of lipid messengers in

165 Phosphatidic acid (PA) is a critical metabolite at the h

166 Phosphatidic acid (PA) is a key phospholipid in glycerol

167 Phosphatidic acid (PA) is a lipid second messenger locat

168 Phosphatidic acid (PA) is a pleiotropic lipid second mes

169 Phosphatidic acid (PA) is a potent lipid secondary messe

170 Phosphatidic acid (PA) is both a central phospholipid bi

171 Phosphatidic acid (PA) is the first glycerolipid formed

172 Phosphatidic acid (PA) is the simplest phospholipid natu

173 restored by treatment with the PLD product, phosphatidic acid (PA) or adenoviral PLD1 expression in

174 Phosphatidic acid (PA) or Nuclear Receptors (NR) PPARalp

175 actors also induce the phospholipase D (PLD)-phosphatidic acid (PA) pathway, required for mTORC1 sign

176 tor of DNA-bound transcription factors and a phosphatidic acid (PA) phosphatase (PAP) enzyme that cat

177 or Opi1 preferentially binds to C16 over C18 phosphatidic acid (PA) species: thus, C16-chain containi

178 ome precursors and we show that HS1BP3 binds phosphatidic acid (PA) through its PX domain.

179 plant defensin NsD7 targets the phospholipid phosphatidic acid (PA) to form oligomeric complexes that

180 glyceride synthesis and dephosphorylation of phosphatidic acid (PA) to generate diacylglycerol.

181 A critical factor regulating mTOR is phosphatidic acid (PA), a central metabolite of membrane

182 This reliance of S6K on phosphatidic acid (PA), a curvature-inducing phospholipi

183 Phosphatidic acid (PA), a second messenger typically der

184 the signaling protein phospholipase D (PLD), phosphatidic acid (PA), and a specific set of microRNAs

185 sphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA), and both DAG and PA are lipid me

186 choline (PC), phosphatidylethanolamine (PE), phosphatidic acid (PA), and sphingomyelin (SM) in a safe

187 (PLD2), which generates the signaling lipid phosphatidic acid (PA), inhibits lung metastases in the

188 ance between DAG and its downstream product, phosphatidic acid (PA), is essential for controlling mic

189 ular content of lysophosphatidic acid (LPA), phosphatidic acid (PA), or diacylglycerol (DAG), respect

190 to m/z of 1000, including lyso-phospholipid, phosphatidic acid (PA), phosphoethanolamine (PE), phosph

191 Through its production of phosphatidic acid (PA), phospholipase D (PLD) is strongl

192 (PLD)2, which generates the signaling lipid phosphatidic acid (PA), reduced neointimal formation in

193 D (PLD) and its enzymatic reaction product, phosphatidic acid (PA), regulate cell adhesion of immune

194 ase (PIP5KI), which in turn is controlled by phosphatidic acid (PA), the product of the DGK reaction.

195 pha), which phosphorylates diacylglycerol to phosphatidic acid (PA), was required for RCP to be mobil

196 by lipid-derived second messengers, such as phosphatidic acid (PA), we sought to determine if dimini

197 hydrolyzes membrane phospholipids to produce phosphatidic acid (PA), which has been proposed to play

198 n resistance in liver by activating PKC, and phosphatidic acid (PA), which inhibits insulin action in

199 estigated the regulation of TREK channels by phosphatidic acid (PA), which is generated by phospholip

200 h phosphorylate and activate PLD1 to produce phosphatidic acid (PA).

201 ts, and root hairs had an increased level of phosphatidic acid (PA).

202 4 has been shown to bind to the phospholipid phosphatidic acid (PA).

203 to directly interact with the lipid mediator phosphatidic acid (PA).

204 spholipase D (PLD) and its reaction product, phosphatidic acid (PA).

205 lates with an accumulation of its substrate, phosphatidic acid (PA).

206 tulated with the addition of the PLD product phosphatidic acid (PA).

207 g in the LD phospholipid monolayer and binds phosphatidic acid (PA).

208 )-dependent increase in the concentration of phosphatidic acid (PA).

209 and subsequent production of signaling lipid phosphatidic acid (PA).

210 rm activate phospholipase D (PLD) to elevate phosphatidic acid (PA).

211 pathways including the dephosphorylation of phosphatidic acid (PA).

212 glycerol (DAG) as a substrate and generating phosphatidic acid (PA).

213 nsidered feedback loops involving the lipid, phosphatidic acid (PA).

214 s in response to the signaling phospholipid, phosphatidic acid (PA).

215 are sequestered away from SNAREs by binding phosphatidic acid (PA).

216 ts substrate to produce the signalling lipid phosphatidic acid (PA).

217 CTP-dependent phosphorylation of DAG to form phosphatidic acid (PA).

218 cerols (PG), phosphatidylethanolamines (PE), phosphatidic acids (PA), and fatty acids.

219 id metabolites, fatty acids, amino acids and phosphatidic acid (PAs), phosphatidylglycerol (PGs), gly

220 molecular species with oxidized acyl chains, phosphatidic acids (PAs)), tri- and tetra-galactosyldiac

221 sphate synthesis and in the flux through the phosphatidic acid pathway, we then created mutations and

222 sX's product to PlsY, the next enzyme in the phosphatidic acid pathway.

223 sed of phospholipids phosphatidylcholine and phosphatidic acid (PC/PA) or phosphatidylcholine and pho

224 e found that LPIN1, which encodes lipin-1, a phosphatidic acid phosphatase (PAP) controlling the rate

225 The lipin phosphatidic acid phosphatase (PAP) enzymes are required

226 While all lipins (lipin 1, 2, and 3) act as phosphatidic acid phosphatase (PAP) enzymes, which are r

227 Lipin 2 is a phosphatidic acid phosphatase (PAP) responsible for the

228 telet-derived growth factor (PDGF)-beta, and phosphatidic acid phosphatase 2b (PPAP2B).

229 Lipin-1 is a Mg(2+)-dependent phosphatidic acid phosphatase involved in the de novo sy

230 lope-enriched activator of the ER-associated phosphatidic acid phosphatase lipin that promotes synthe

231 We show that inactivation of Ned1, the phosphatidic acid phosphatase of the lipin family, by CD

232 Mon1-Ccz1 is absent on vacuoles lacking the phosphatidic acid phosphatase Pah1, which also lack Ypt7

233 PhosPhatidic Acid Phosphatase type 2B (PPAP2B), an integ

234 Lipin/Pah phosphatidic acid phosphatases (PAPs) generate diacylgly

235 Lipins 1, 2, and 3 are Mg(2+)-dependent phosphatidic acid phosphatases and catalyze the penultim

236 e family encodes a class of Mg(2+)-dependent phosphatidic acid phosphatases involved in the de novo s

237 each line has an individual pattern of DAG, phosphatidic acid, phosphatidylcholine, and triacylglyce

238 Twenty-eight different lipid species (phosphatidic acids, phosphatidylethanolamines, phosphati

239 d with medulloblastoma metastasis, including phosphatidic acids, phosphatidylethanolamines, phosphati

240 We identified phosphatidic acid, phosphatidylglycerol, and glycerol ph

241 MGDG) content in ads2 mutants were lower and phosphatidic acid, phosphatidylinositol, phosphatidyleth

242 Anionic phospholipids, which include phosphatidic acid, phosphatidylserine, and phosphoinosit

243 The anionic phospholipids, phosphatidic acid, phosphatidylserine, phosphatidylglyce

244 We previously showed that the disruption of PHOSPHATIDIC ACID PHOSPHOHYDROLASE (PAH) activity in Ara

245 ates glycerolipid homeostasis by acting as a phosphatidic acid phosphohydrolase (PAP) enzyme in the t

246 Loss of lipin 1-mediated phosphatidic acid phosphohydrolase activity in muscle le

247 a protein that exhibits dual functions as a phosphatidic acid phosphohydrolase enzyme in the triglyc

248 We previously reported that disruption of PHOSPHATIDIC ACID PHOSPHOHYDROLASE1 (PAH1) and PAH2 stim

249 We show that cytosolic phosphatidic acid phospholipase A1 (PAPLA1) interacts wi

250 le for lipins as determinants of levels of a phosphatidic acid pool that influences Pparg expression.

251 acid by an acyl CoA substrate to produce the phosphatidic acid precursor of polar glycerolipids and t

252 Cellular levels of phosphatidic acid, precursor to all membrane phospholipi

253 , PstB2p, and Pbi1p that ligate to Scs2p and phosphatidic acid present in the donor membrane, forming

254 The membrane lipid phosphatidic acid, produced by phospholipase D (PLD), ha

255 In addition to the expected phosphatidic acid-producing kinase activity, DGK4 recomb

256 Chemical inhibition of phosphatidic acid production by PLD increased the penetr

257 We propose that Phospholipase D-derived phosphatidic acid promotes ectopic Notch signalling by i

258 embrane of the chloroplast, while TGD4 binds phosphatidic acid (PtdOH) and resides in the outer chlor

259 Similarly, phosphatidic acid (PtdOH), generated from diacylglycerol

260 otein when fused to DsRED specifically binds phosphatidic acid (PtdOH).

261 It remains unknown, however, whether phosphatidic acid regulates Notch-mediated binary cell-f

262 t DGKalpha is required for the generation of phosphatidic acid required for tubular recycling endosom

263 Exogenously added phosphatidic acid rescued the PLD-inhibition phenotype,

264 DAG kinases (DGKs) convert DAG into phosphatidic acid, resulting in termination of DAG signa

265 that enables DEP domain-mediated binding to phosphatidic acid, resulting in the tethering of Epac1 a

266 eraction of CP with phospholipids, including phosphatidic acid, results in uncapping of filament ends

267 nase or phospholipase D-enzymes that produce phosphatidic acid-reveal a role for phosphatidic acid in

268 which phosphorylates diacylglycerol to yield phosphatidic acid, selectively dissociates Rac1 by stimu

269 ellular trafficking, lipid biosynthesis, and phosphatidic acid signaling pathway.

270 ntrols the switch between diacylglycerol and phosphatidic acid signaling pathways.

271 imaged, including phosphatidylethanolamines, phosphatidic acids, sterols, and gossypol, indicating th

272 nalysis, and determined that fully saturated phosphatidic acids such as 1,2-distearoyl-PA (18:0/18:0-

273 d intermediates such as free fatty acids and phosphatidic acid, suggesting a buffer function of TAG a

274 l characterization showed that G0S2 mediates phosphatidic acid synthesis from lysophosphatidic acid (

275 yoelii has an incomplete apicoplast-targeted phosphatidic acid synthesis pathway that is essential fo

276 s are being utilized for apicoplast-targeted phosphatidic acid synthesis, the phospholipid precursor.

277 - and cytosol/endoplasmic reticulum-targeted phosphatidic acid synthesis.

278 ese data reveal a signaling pathway by which phosphatidic acid synthesized via the glycerol-3-phospha

279 cyltransferase pathway for the biogenesis of phosphatidic acid that begins with the acylation of sn-g

280 volving PTPD2 and the lipid second messenger phosphatidic acid that promotes ERBB2 function.

281 en the mitochondrial fission GTPase Drp1 and phosphatidic acid that restrains Drp1 activity and shift

282 we report an itch-inducing molecule, cyclic phosphatidic acid, that activates TRPV1 and whose prurit

283 hospholipase D (PLD) generates a metabolite, phosphatidic acid, that facilitates association between

284 marked increase of diacylglycerol (DAG) and phosphatidic acid, the precursors for TAG, in the mutant

285 nmask a cross-talk between the metabolism of phosphatidic acid, the product of phospholipase D(2), an

286 types were associated with reduced levels of phosphatidic acid, the product of PLD activity and were

287 LD inhibitors and siRNA knockdowns establish phosphatidic acid, the product of the PLD reaction, as a

288 , which is responsible for the conversion of phosphatidic acid to CDP-diacylglycerol in phospholipid

289 ve feedback loop in which DGKalpha generates phosphatidic acid to drive its own recruitment to TRE vi

290 ck the conversion of glycerophospholipids to phosphatidic acid) to deplete cellular TRE, we observed

291 ged phospholipids (e.g., bilayers containing phosphatidic acid together with sphingomyelins, phosphat

292 st that interfering with the CDP-DG route of phosphatidic acid utilization rewires cellular metabolis

293 phate, phosphatidylinositol 3-phosphate, and phosphatidic acid was nearly identical in all phagosomes

294 nse to fungal infection an overexpression of phosphatidic acids was discovered.

295 protein Syndapin2 associate selectively with phosphatidic acid, we propose a positive feedback loop i

296 ed oils whereas phosphatidylethanolamine and phosphatidic acid were less abundant.

297 elf regulated by phospholipids, specifically phosphatidic acid, whereby 300 nM 1,2-dioleoyl-sn-glycer

298 and the BAR-domain protein syndapin2 bind to phosphatidic acid, which we identify as a novel lipid co

299 of PLD-induced cell invasion is mediated by phosphatidic acid, Wiscott-Aldrich Syndrome protein, gro

300 Species of phosphatidic acid with two unsaturated acyl chains are m