ライフサイエンスコーパス: phosphatidylethanol

1 activity, as indicated by the production of phosphatidylethanol.

2 PLD, as shown by a sustained accumulation of phosphatidylethanol.

3 d both PMA-induced PLD-mediated formation of phosphatidylethanol (approximately 5-fold) and the hydro

4 Furthermore, the metabolite phosphatidylethanol directly competes for the endogenous

5 -conjugated sphingols (C2 ceramides) blocked phosphatidylethanol formation indicating that phospholip

6 model membranes of phosphatidylcholines and phosphatidylethanols have been studied as a function of

7 alpha-thrombin-induced production of nuclear phosphatidylethanol in quiescent cells incubated in the

8 ned by formation of the PLD-specific product phosphatidylethanol in the presence of 0.5% ethanol.

9 te-labeled phosphatidylcholine conversion to phosphatidylethanol in the presence of 2% ethanol.

10 Phosphatidylethanol is formed when ethanol substitutes i

11 , and an objective biomarker of alcohol use (phosphatidylethanol level).

12 vo PLD activity, as assessed by detection of phosphatidylethanol levels using mass spectrometry (MS)

13 st, phosphatidylalcohols exhibited only 25% (phosphatidylethanol) or 5% (phosphatidylbutanol) of the

14 eased generation of the PLD-specific product phosphatidylethanol (PEt) (9.9-fold increases in [3H]-PE

15 (TPA) in the presence of ethanol synthesize phosphatidylethanol (PEt) instead of phosphatidic acid (

16 se in PLD activity, as indicated by elevated phosphatidylethanol (PEt) production.

17 ures: ethyl glucuronide in urine samples and phosphatidylethanol (PEth) in dried blood spot samples.

18 In-vitro studies showed that the levels of phosphatidylethanol (PEth) in human red blood cells were

19 a key driver of liver-related mortality, and phosphatidylethanol (PEth) is a direct biomarker of alco

20 Phosphatidylethanol (PEth) is a highly specific alcohol

21 lcohol use in clinical care, yet cutoffs for phosphatidylethanol (PEth), a blood biomarker, have not

22 epigenome-wide association study (EWAS) for phosphatidylethanol (PEth), an objective measure of alco

23 eport (AUDIT-C <3 for women, <4 for men) and phosphatidylethanol (PEth; past-month alcohol biomarker)

24 moderate/heavy alcohol use by the biomarker phosphatidylethanol ([Peth] >=50 ng/mL), and 44% had uri

25 ipants, 70 (24.5%) had moderate alcohol use (phosphatidylethanol [PEth], 20-200 ng/mL), 81 (28.3%) ha

26 ion reaction, resulting in the production of phosphatidylethanol rather than PA.

27 Lissamine rhodamine B-dipalmitoyl phosphatidylethanol was incorporated into the liposome b

28 shown to generate alcohol metabolites (e.g., phosphatidylethanol) with a cutoff, but no phenotype has