ライフサイエンスコーパス: phosphatidylinositol

1 Phosphatidylinositol 3 kinase (PI3K) inhibition also abo

2 ing pathway, like Bruton tyrosine kinase and phosphatidylinositol 3 kinase.

3 phatidylinositol 3-phosphate and its product phosphatidylinositol 3, 5-bisphosphate, and a WIPI-bindi

4 xtent, due to enhanced insulin signaling via phosphatidylinositol 3,4,5-triphosphate (PIP(3)).

5 , Slit2-S activated Ras but did not increase phosphatidylinositol 3,4,5-triphosphate levels.

6 did not appear to activate Ras but increased phosphatidylinositol 3,4,5-triphosphate levels.

7 ckstrin homology (PH) domain that recognizes phosphatidylinositol 3,4,5-trisphosphate (PIP3).

8 RAP1 binds PIP5Pase substrate phosphatidylinositol 3,4,5-trisphosphate [PI(3,4,5)P3],

9 During podosome formation, distinct phosphatidylinositol 3,4,5-trisphosphate lipid (PI(3,4,5

10 regulatory subunits (RIalpha) interact with phosphatidylinositol 3,4,5-trisphosphate-dependent Rac e

11 investigated whether Gbetagamma signaling to phosphatidylinositol 3,4,5-trisphosphate-dependent Rac e

12 to phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate.

13 linositol 4,5-bisphosphate (PI(4,5)P(2)) and phosphatidylinositol 3,4-bisphosphate (PI(3,4)P(2)).

14 In light of this, the effect of phosphatidylinositol 3,5-bisphosphate (PI(3,5)P(2)) on v

15 he low-level endo-lysosomal signaling lipid, phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2), is re

16 rlay assay showed specific binding of SVB to phosphatidylinositol 3,5-bisphosphate and phosphatidylin

17 yrosine kinase (TK) inhibitor, genistein and phosphatidylinositol 3-kinase (PI-3K) inhibitor, wortman

18 ted the mitogen-activated protein kinase and phosphatidylinositol 3-kinase (PI3'K) pathways with the

19 keletal muscle insulin resistance, decreased phosphatidylinositol 3-kinase (PI3K) activation and alte

20 and identified high-value targets, including phosphatidylinositol 3-kinase (PI3K) and cyclin-dependen

21 In HNSCC, genetic aberrations in phosphatidylinositol 3-kinase (PI3K) and epidermal growt

22 70 coopted replicase assembly factors, Vps34 phosphatidylinositol 3-kinase (PI3K) and the membrane-be

23 ibited the activating phosphorylation of the phosphatidylinositol 3-kinase (PI3K) effector Akt induce

24 of autophagosome elongation by the class III phosphatidylinositol 3-kinase (PI3K) inhibitor 3-methyla

25 uced transcription factor that downregulates phosphatidylinositol 3-kinase (PI3K) levels to activate

26 signaling, including that of MET, downstream phosphatidylinositol 3-kinase (PI3K) mediates both cell

27 Phosphatidylinositol 3-kinase (PI3K) signaling is highly

28 The phosphatidylinositol 3-kinase (PI3K) signaling pathway i

29 Targeting both CD20 and phosphatidylinositol 3-kinase (PI3K), a protein that is

30 g: 3' phosphatase and tensin homolog (PTEN), phosphatidylinositol 3-kinase (PI3K), or 5' Src homology

31 onetheless requires actin dynamics, Syk, and phosphatidylinositol 3-kinase (PI3K).

32 y enlarged brains, and overactivation of the phosphatidylinositol 3-kinase (PI3K)/Akt (protein kinase

33 R2 encodes the p85beta regulatory subunit of phosphatidylinositol 3-kinase and is frequently amplifie

34 found that local synthesis of PI(3,4)P(2) by phosphatidylinositol 3-kinase C2alpha at plasma membrane

35 regulates the assembly of the endolysosomal phosphatidylinositol 3-kinase complex (PI3KC3-C2)-which

36 Atg5, and Vps34, and other components of the phosphatidylinositol 3-kinase complex.

37 The phosphatidylinositol 3-kinase delta (PI3K-delta) inhibit

38 ext-generation, potent, and highly selective phosphatidylinositol 3-kinase delta (PI3Kdelta) inhibito

39 e blood with isoform selective inhibitors of phosphatidylinositol 3-kinase dose dependently modulate

40 ulin-induced effect on FOXO1 nuclear efflux, phosphatidylinositol 3-kinase inhibitors, which we show

41 ociated with reductions in integrin-paxillin-phosphatidylinositol 3-kinase signaling in vivo.

42 Pro-rich peptide ligand to the SH3 domain of phosphatidylinositol 3-kinase unfolded in the presence o

43 Dia2 and an endosomal effector protein, the phosphatidylinositol 3-kinase Vps34.

44 lin via a pathway including IGF1 or insulin, phosphatidylinositol 3-kinase, and AKT.

45 Inhibition of phosphatidylinositol 3-kinase, or its downstream effecto

46 generating hyperactive alleles of the yeast phosphatidylinositol 3-kinase, Vps34.

47 Overexpressing phosphatidylinositol 3-kinase-an enzyme essential for os

48 Activated phosphatidylinositol 3-kinase-delta (PI3K-delta) syndrom

49 Phosphatidylinositol 3-kinase-gamma (PI3Kgamma) is highl

50 hat regulates the steady-state levels of all phosphatidylinositol 3-kinase-like protein kinases, incl

51 of FUS's prion-like domain (PrLD) by nuclear phosphatidylinositol 3-kinase-related kinase (PIKK)-fami

52 site phosphorylation, activates the cellular phosphatidylinositol 3-kinase-related kinase ATM to caus

53 ivers of the DDR are multiple members of the phosphatidylinositol 3-kinase-related kinase family, inc

54 Ca(2+)-sensing proteins and SMG1, encoding a phosphatidylinositol 3-kinase-related kinase.

55 -dependent protein kinase (DNA-PK), like all phosphatidylinositol 3-kinase-related kinases (PIKKs), i

56 For nearly 30 years, the conserved phosphatidylinositol 3-kinase-related protein kinases (P

57 , and the induction of CXCL11-CXCR3 axis and phosphatidylinositol 3-kinase/AKT pathways.

58 ation and survival through activation of the phosphatidylinositol 3-kinase/AKT-, RAS/MAPK-, and STAT5

59 rotocol 2, whereas it additionally inhibited phosphatidylinositol 3-kinase/Akt/endothelial nitric oxi

60 We demonstrate that the phosphatidylinositol 3-kinase/AKT/GSK-3beta pathway inte

61 The phosphatidylinositol 3-kinase/Akt/mammalian target of ra

62 ciently controls IL-23- and IL-1beta-induced phosphatidylinositol 3-kinase/AKT/mTOR activation indepe

63 an target of rapamycin (mTOR) and associated phosphatidylinositol 3-kinase/AKT/mTOR signaling pathway

64 repair genes (eg, BRCA2 and ATM) in 60%, and phosphatidylinositol 3-kinase/mitogen-activated protein

65 Targeting the B-cell receptor and phosphatidylinositol 3-kinase/mTOR signaling pathways ha

66 ied in more than one tissue, including PI3K (phosphatidylinositol 3-kinase/protein kinase-B) signalin

67 Phosphatidylinositol 3-kinases (PI3Ks) are a family of l

68 Phosphatidylinositol 3-phosphate (PI(3)P) levels in Plas

69 le (AV) biogenesis through the generation of phosphatidylinositol 3-phosphate (PI3P) and the recruitm

70 (ATG2), the rod-shaped protein that tethers phosphatidylinositol 3-phosphate (PI3P)-enriched phagoph

71 rect binding to phosphoinositides, including phosphatidylinositol 3-phosphate (PI3P).

72 Phosphatidylinositol 3-phosphate (PtdIns(3)P) is a phosp

73 acting protein (WIPI)2, a protein that binds phosphatidylinositol 3-phosphate and its product phospha

74 by a GFP-tagged 2xFYVE protein that binds to phosphatidylinositol 3-phosphate.

75 ignaling roles of its minor lipid messenger, phosphatidylinositol (3,4)-bisphosphate (PI(3,4)P(2)), a

76 Phosphatidylinositol (3,4,5) trisphosphate (PIP(3))-depe

77 a thermal shift screen directed against the phosphatidylinositol (3,4,5) trisphosphate-dependent Rac

78 to mediate delivery of the second messenger phosphatidylinositol (3,4,5)-trisphosphate (PIP(3)) to t

79 Phosphatidylinositol (3,4,5)-trisphosphate (PIP(3))-depe

80 tol 4,5-bisphosphate (PI(4,5)P2) and reduced phosphatidylinositol (3,4,5)-trisphosphate (PIP3) levels

81 ated the activation of proteins that require phosphatidylinositol (3,4,5)-trisphosphate (PtdIns(3,4,5

82 As expected, a decrease of phosphatidylinositol (3,4,5)-trisphosphate pools and AKT

83 Mechanistically, the interaction of phosphatidylinositol (3,4,5)-trisphosphate with AKT faci

84 -binding kinetic measurements, we identify a phosphatidylinositol (3-5)-trisphosphate (PIP(3)) sensin

85 inducible factor 2alpha (HIF-2alpha) and the Phosphatidylinositol-3 kinase (PI(3) -Kinase)/AKT/Serum

86 t have the ability to simultaneously bind to phosphatidylinositol-3 kinase (PI3K) and/or cyclin-depen

87 inositide PI(3)P by the autophagic class III phosphatidylinositol-3 kinase complex I (PI3KC3-C1) and

88 ia represents a major advance, including the phosphatidylinositol-3'-kinase (PI3K) p110delta inhibito

89 tumor resistance due to redundancies in the phosphatidylinositol-3'-kinase/protein kinase B and KRAS

90 and results in the sequential generation of phosphatidylinositol-3,4,5-trisphosphate (PI3,4,5P(3)).

91 Here we show that phosphatidylinositol-3,4,5-trisphosphate generation and

92 The membrane lipid phosphatidylinositol-3,4-bisphosphate (PI(3,4)P(2)) is a

93 ive Vps34 drives certain pathways, including phosphatidylinositol-3,5-bisphosphate synthesis and retr

94 The activation of the phosphatidylinositol-3-kinase (PI3K) pathway is a known

95 ogether function as a prototypical class III phosphatidylinositol-3-kinase (PI3K).

96 with beclin 1 and ATG14-containing class III phosphatidylinositol-3-kinase (PI3KC3) complex 1 (PI3KC3

97 , downregulation of the androgen receptor -> phosphatidylinositol-3-kinase -> Akt pathway, upregulati

98 Toll-like receptor 9 (TLR9) and Phosphatidylinositol-3-kinase gamma (PI3Kgamma) are very

99 on stress response, TP53, androgen receptor, phosphatidylinositol-3-kinase/AKT, and MYC signaling.

100 The canonical model of agonist-stimulated phosphatidylinositol-3-OH kinase (PI3K)-Akt signalling p

101 Finally, we show that the conserved phosphatidylinositol-3-phosphate (PI(3)P) binding protei

102 assays revealed that RavD selectively binds phosphatidylinositol-3-phosphate (PI(3)P) in vitro We fu

103 uired to maintain normal endosomal levels of phosphatidylinositol-3-phosphate (PI(3)P).

104 t this hypothesis, we elevated the levels of phosphatidylinositol-3-phosphate (PI3P) by generating hy

105 I) to generate the essential signaling lipid phosphatidylinositol-3-phosphate (PI3P).

106 and is required for endosomal generation of phosphatidylinositol-3-phosphate (PtdIns(3)P) and recrui

107 This was mediated through stimulation of phosphatidylinositol-3-phosphate (PtdIns(3)P) production

108 sed assay also showed stimulatory effects by phosphatidylinositol-3-phosphate [PI(3)P] and ergosterol

109 complexes responsible for the generation of phosphatidylinositol-3-phosphate.

110 ll-molecule inhibitors of the main endosomal phosphatidylinositol-3-phosphate/phosphatidylinositol 5-

111 K-A expression facilitated crosstalk between phosphatidylinositol-(3,4,5)-trisphosphate and inhibitor

112 CD63-mediated SG maturation requires type II phosphatidylinositol 4 kinase (PI4KII)-dependent early e

113 uration to membranes containing PS even if a phosphatidylinositol 4,5 bisphosphate membrane is presen

114 penetrate in trans to a membrane containing phosphatidylinositol 4,5 bisphosphate, even if phosphati

115 Many actin-regulatory proteins interact with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)) and

116 yn with the acidic phosphoinositides (PIPs), phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)) and

117 we show that Flower Ca(2+) channel-dependent phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)) comp

118 osphoinositides and the other explaining how phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)) infl

119 by the Galphaq/phospholipase Cbeta (PLCbeta)/phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)) sign

120 RTKs can hydrolyze phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)) with

121 lysosomes, whereas PI 4-phosphates, such as phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)), are

122 Weak TCR signals generated elevated phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) and re

123 i/o) activation of TRPC4 through hydrolysing phosphatidylinositol 4,5-bisphosphate (PIP(2) ) to produ

124 ally dependent on and bimodally regulated by phosphatidylinositol 4,5-bisphosphate (PIP(2) ), the sub

125 TRPC1 proteins to promote channel opening by phosphatidylinositol 4,5-bisphosphate (PIP(2) ).

126 on of TRPC1 essential for channel opening by phosphatidylinositol 4,5-bisphosphate (PIP(2) ).

127 In contrast, swapping carboxy-terminal phosphatidylinositol 4,5-bisphosphate (PIP(2)) binding d

128 Phosphatidylinositol 4,5-bisphosphate (PIP(2)) has a sig

129 ransition of this region that is promoted by phosphatidylinositol 4,5-bisphosphate (PIP(2)) is also p

130 h mutant forms of Merlin that cannot bind to phosphatidylinositol 4,5-bisphosphate (PIP(2)) or that c

131 The plasma membrane phospholipid phosphatidylinositol 4,5-bisphosphate (PIP(2)) regulates

132 nsporter (hSERT), in which direct binding of phosphatidylinositol 4,5-bisphosphate (PIP(2)) stabilize

133 n of G(q/11)-coupled receptors both consumes phosphatidylinositol 4,5-bisphosphate (PIP(2)) via phosp

134 s disrupt current potentiation by increasing phosphatidylinositol 4,5-bisphosphate (PIP(2)), and our

135 dynamically regulated plasma membrane lipid phosphatidylinositol 4,5-bisphosphate (PIP(2)), but it i

136 steric actions of agonist and membrane lipid phosphatidylinositol 4,5-bisphosphate (PIP(2)), but lack

137 The phosphoinositide, phosphatidylinositol 4,5-bisphosphate (PIP(2)), has long

138 persistence in bulk membranes, in particular phosphatidylinositol 4,5-bisphosphate (PIP(2)), initiall

139 RF GAP domains of ASAP1, and is modulated by phosphatidylinositol 4,5-bisphosphate (PIP(2)).

140 undown is common among channels regulated by phosphatidylinositol 4,5-bisphosphate (PIP(2)).

141 The lipid phosphatidylinositol 4,5-bisphosphate (PIP2) forms nanos

142 from the cell-surface, and redistribution of phosphatidylinositol 4,5-bisphosphate (PIP2) from the pl

143 Phosphatidylinositol 4,5-bisphosphate (PIP2) is critical

144 ctivation of IPF fibroblasts, we noticed the phosphatidylinositol 4,5-bisphosphate (PIP2)-binding pro

145 pha (also known as PIP5K1A)) and its product phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P(2)).

146 M8 requires the plasma membrane phospholipid phosphatidylinositol 4,5-bisphosphate [PI(4,5)P(2) or PI

147 ) enzyme and to lead to a robust decrease in phosphatidylinositol 4,5-bisphosphate [PI(4,5)P(2)] leve

148 evation of cytosolic Ca(2+) and modulated by phosphatidylinositol 4,5-bisphosphate [PI(4,5)P(2)].

149 pase C pathway, leading to the hydrolysis of phosphatidylinositol 4,5-bisphosphate [PI(4,5)P(2)].

150 for both cooling agonists and membrane lipid phosphatidylinositol 4,5-bisphosphate [PI(4,5)P(2)].

151 AT1508 is an allosteric modulator of channel-phosphatidylinositol 4,5-bisphosphate interactions.

152 Neurites induce formation of plasma membrane phosphatidylinositol 4,5-bisphosphate microdomains at na

153 The latter was due to accumulation of phosphatidylinositol 4,5-bisphosphate PI(4,5)P2 in endol

154 embrane and electrostatically interacts with phosphatidylinositol 4,5-bisphosphate to stabilize MA or

155 , an endosome-localized enzyme that produces phosphatidylinositol 4,5-bisphosphate, directly interact

156 ds of an I-BAR domain, we find clustering of phosphatidylinositol 4,5-bisphosphate-like lipids that i

157 When we include phosphatidylinositol 4,5-bisphosphate-like lipids that p

158 ivity is promoted by G proteins that deplete phosphatidylinositol 4,5-bisphosphate.

159 through SC-specific genetic inactivation of phosphatidylinositol 4-kinase beta (PI4KB), a Golgi-asso

160 Here we show that the lipid kinase phosphatidylinositol 4-kinase III beta (PI4KIIIbeta) reg

161 ysis identified the evolutionarily conserved phosphatidylinositol 4-kinase IIIalpha (PI4KIIIalpha), a

162 n revealed that Pipinib selectively inhibits phosphatidylinositol 4-kinase IIIbeta (PI4KB) and suppre

163 ibosylation factor 1 (Arf1) or its effector, phosphatidylinositol 4-kinase IIIbeta [PI(4)KIIIbeta], i

164 MMV390048 is the first Plasmodium phosphatidylinositol 4-kinase inhibitor to reach clinica

165 iazolopyridine core disturbed the binding to phosphatidylinositol 4-kinase, catalytic beta (PIK4CB).

166 Thus, Nir2, along with VAPs, OSBP, and the phosphatidylinositol 4-kinase, completes a cycle of phos

167 osphate (PI4P) biosynthesis regulated by the phosphatidylinositol 4-kinases PI4KIIIbeta1 and PI4KIIIb

168 exchange key lipids, such as cholesterol and phosphatidylinositol 4-phosphate (PI(4)P), between organ

169 Here, we demonstrate that phosphatidylinositol 4-phosphate (PI4P) biosynthesis reg

170 PI4KIIIbeta generates phosphatidylinositol 4-phosphate (PI4P) from phosphatidy

171 nding of pleckstrin homology (PH) domains to phosphatidylinositol 4-phosphate (PI4P) in the yeast tra

172 early endosomal sorting and accumulation of phosphatidylinositol 4-phosphate (PI4P) on SG membranes.

173 tional co-distribution of unsaturated PS and phosphatidylinositol 4-phosphate (PI4P) species in stero

174 d, ER-localized phosphatase whose substrate, phosphatidylinositol 4-phosphate (PI4P), coordinates sec

175 STING was expressed on phosphatidylinositol 4-phosphate (PI4P)-enriched membran

176 1 induces its PH domain to recognize instead phosphatidylinositol 4-phosphate (PI4P).

177 tic activity of the protein is stimulated by phosphatidylinositol 4-phosphate (PI4P).

178 help channel production of specific pools of phosphatidylinositol 4-phosphate (PtdIns(4)P) dedicated

179 h protein ligands, synergistically stimulate phosphatidylinositol 4-phosphate 5-kinase (PIP5K) activi

180 Cdk5-mediated phosphorylation regulates phosphatidylinositol 4-phosphate 5-kinase type I gamma 9

181 Elevated levels of phosphatidylinositol 4-phosphate [PI(4)P] in HCV replica

182 Here, we found that microdomains of phosphatidylinositol 4-phosphate [PI(4)P] on trans-Golgi

183 we found that deletion or depletion of Sac1 phosphatidylinositol 4-phosphate [PI(4)P] phosphatase re

184 he HCV replication organelle in exchange for phosphatidylinositol 4-phosphate [PI(4)P].

185 le interactions with plasma membrane lipids: Phosphatidylinositol (4, 5)-bisphosphate (PIP(2)) activa

186 have previously shown that the phospholipid, phosphatidylinositol (4, 5)-bisphosphate (PIP(2)), direc

187 interaction of ExoU with soluble analogs of phosphatidylinositol (4,5)-bisphosphate (PI(4,5)P(2)).

188 We also identify a unique phosphatidylinositol (4,5)-bisphosphate (PIP(2)) interac

189 Here we show that phosphatidylinositol (4,5)-bisphosphate (PIP(2)) regulat

190 e proteins are critical for the synthesis of phosphatidylinositol (4,5)-bisphosphate [PI(4,5)P(2)], a

191 ion between K-Ras4B with the signaling lipid phosphatidylinositol (4,5)-phosphate (PIP2).

192 Phospholipase C (PLC)s degrade phosphatidylinositol-4, 5-bisphosphate (PI(4,5)P2) lipid

193 Phosphatidylinositol-4,5-bisphosphate (PI-4,5-P(2) ) is

194 he Syt-7 C2AB tandem binds liposomes lacking phosphatidylinositol-4,5-bisphosphate (PIP(2)) with grea

195 Phosphatidylinositol-4,5-bisphosphate (PIP2) is an impor

196 domains that exhibit specificity for binding phosphatidylinositol-4,5-bisphosphate (PtdIns4,5P2).

197 rms that one important physiological signal, phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) ac

198 ound to be mediated at least in part through phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) ac

199 sequencing found a missense mutation in the Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic

200 Pik3cg, encoding phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic

201 ncers (CRCs) with oncogenic mutations in the phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic

202 ential methylation of two replicated PIK3CD (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic

203 taining 2 mol % 1,2-dipalmitoyl-sn-glycero-3-phosphatidylinositol-4,5-bisphosphate and Atto488-1,2-di

204 membrane, where receptors are activated and phosphatidylinositol-4,5-bisphosphate is concentrated.

205 In addition, we observe a phosphatidylinositol-4,5-bisphosphate molecule forming a

206 Each GABA(A) receptor pentamer contains two phosphatidylinositol-4,5-bisphosphate molecules, the hea

207 es the interactions with the signaling lipid phosphatidylinositol-4,5-bisphosphate.

208 hosphatidylinositol-4-phosphate [PI(4)P] and phosphatidylinositol-4,5-phosphate [PI(4,5)P(2)] on memb

209 We show herein that phosphatidylinositol-4-kinase IIalpha (PI4KIIalpha) play

210 n activator and is specifically activated by phosphatidylinositol-4-phosphate (PI4P), although the un

211 Phosphatidylinositol-4-phosphate (PtdIns(4)P), which is

212 larized localization of plasma membrane (PM) phosphatidylinositol-4-phosphate (PtdIns4P) directs the

213 TLR4 responses in murine DCs by generating a phosphatidylinositol-4-phosphate (PtdIns4P) platform con

214 control of PI(4,5)P(2) production by type-I phosphatidylinositol-4-phosphate 5-kinase (PIP5KI), whic

215 We investigated the role of phosphatidylinositol-4-phosphate 5-kinase alpha (PIP5Kal

216 g to identify OsPIP5K1, a member of the rice phosphatidylinositol-4-phosphate 5-kinase family, as a p

217 generated by two families of kinases: type 1 phosphatidylinositol-4-phosphate 5-kinases, encoded by P

218 reaction that drives the interconversion of phosphatidylinositol-4-phosphate [PI(4)P] and phosphatid

219 in autophagy-related (ATG)-9A and the lipid, phosphatidylinositol-4-phosphate [PI(4)P].

220 , and SAC1 phosphatase that dephosphorylates phosphatidylinositol-4-phosphate as potential candidate

221 te OSBP-VAP ER-Golgi tethering implicated in phosphatidylinositol-4-phosphate transport and metabolis

222 l C2 domains (C2A and C2B) with affinity for phosphatidylinositol-(4,5)-bisphosphate (PIP(2)).

223 o re-synthesize phosphoinositides, including phosphatidylinositol-(4,5)-bisphosphate (PIP2), resultin

224 highly basic region (MA-HBR) interacts with phosphatidylinositol-(4,5)-bisphosphate [PI(4,5)P2], a P

225 to PM sites is facilitated by its binding to phosphatidylinositol-(4,5)-bisphosphate [PI(4,5)P2], and

226 n endosomal phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, PIKfyve.

227 We show that nuclear phosphatidylinositol 5-phosphatase (PIP5Pase) interacts

228 r role in many important signaling pathways, phosphatidylinositol 5-phosphate 4-kinases (PI5P4Ks) are

229 proteins is not allosterically regulated by phosphatidylinositol 5-phosphate that interacts with a s

230 en consumption and promotes the synthesis of phosphatidylinositol-5-phosphate (PtdIns5P), which trigg

231 by PIP5K1A, PIP5K1B and PIP5K1C, and type 2 phosphatidylinositol-5-phosphate 4-kinases, encoded by P

232 phosphatidylinositol 4-phosphate (PI4P) from phosphatidylinositol and is highly expressed in a subset

233 phospholipids including phosphatidylcholine, phosphatidylinositol and phosphatidylethanolamine.

234 gnificantly affect phosphatidylethanolamine, phosphatidylinositol, and phosphatidylserine profiles.

235 s are defined by their abilities to transfer phosphatidylinositol between membranes in vitro, and to

236 rtase supports heterotetramer formation, and phosphatidylinositol binding at the heterotetramer inter

237 ed risk for the minor allele of rs3851179 in phosphatidylinositol binding clathrin assembly protein w

238 POE), forkhead box class O3a, clusterin, and phosphatidylinositol binding clathrin assembly protein.

239 diated inhibition is mutually exclusive with phosphatidylinositol binding.

240 nner leaflet of the plasma membrane, such as phosphatidylinositol-bisphosphate (PIP(2)) and phosphati

241 ction with anionic lipid (phosphatidylserine/phosphatidylinositol) containing membranes, both in the

242 mechanism in which direct interactions with phosphatidylinositol-containing lipids play an essential

243 anisms to regulate DGKepsilon ensures proper phosphatidylinositol cycle function regardless of the tr

244 ycerol to form phosphatidic acid (PA) in the phosphatidylinositol cycle.

245 not a readily exchangeable ligand, and that phosphatidylinositol-exchange activity is resuscitated i

246 n the CNS with a conditional mouse allele of phosphatidylinositol glycan anchor biosynthesis, class A

247 lelic mutations in PIGB, a gene that encodes phosphatidylinositol glycan class B, which transfers the

248 throcytes fluorescently stained for glycosyl phosphatidylinositol (GPI)-anchored proteins; CD55 and C

249 and biosynthesis of phosphatidylglycerol and phosphatidylinositol in the endoplasmic reticulum (ER).

250 virus infection by 1-stearoyl-2-arachidonoyl-phosphatidylinositol in vitro.

251 Pharmacological inhibition of phosphatidylinositol kinases and cholesterol homeostasis

252 of the cell wall, including the glycolipids phosphatidylinositol mannoside, lipomannan, and lipoarab

253 n lines showed that phosphatidylglycerol and phosphatidylinositol metabolism was affected differently

254 for Shh signal transduction and the ciliary phosphatidylinositol phosphatase Inpp5e is linked to Shh

255 Rs simulated, in particular, cholesterol and phosphatidylinositol phosphate (PIP) lipids, but the num

256 Here, we demonstrate that type Igamma phosphatidylinositol phosphate 5-kinase i5 (PIPKIgammai5

257 Additionally, we identified phosphatidylinositol phosphate biosynthesis and choleste

258 o phosphatase activity, but it can recognize phosphatidylinositol phosphate head groups.

259 pe and mutant p53 is regulated by the type I phosphatidylinositol phosphate kinase (PIPKI-alpha (also

260 stored by expression of wild-type ORP1S or a phosphatidylinositol phosphate-binding mutant but not by

261 framework to strengthen our understanding of phosphatidylinositol-phosphate biosynthesis in the conte

262 idine diphosphate-alcohol phosphotransferase phosphatidylinositol-phosphate synthase (PIPS), an essen

263 acylglycerol and inositol-phosphate to yield phosphatidylinositol-phosphate, the immediate precursor

264 Like the yeast Sec14p, CPSFL1 binds phosphatidylinositol phosphates (PIPs) and phosphatidic

265 Phosphatidylinositol phosphates (PIPs) are membrane phos

266 Total PL and PC, PE, phosphatidylinositol + phosphatidylserine and CL contain

267 re membrane interacting domains that bind to phosphatidylinositol phospholipids or phosphoinositides,

268 es the enzymatic activation of the class III phosphatidylinositol (PI) 3-kinase complex I (PI3KC3-C1)

269 r membrane dynamics and cell signaling, with phosphatidylinositol (PI) 3-phosphates being the predomi

270 In mycobacteria, phosphatidylinositol (PI) acts as a common lipid anchor

271 The phosphatidylinositol (PI) cycle is central to eukaryotic

272 Conversely, rephosphorylation of phosphatidylinositol (PI) derivatives into PIP(2) using

273 Phosphatidylinositol (PI) is an essential structural com

274 SAPI), which is the most abundant endogenous phosphatidylinositol (PI) molecular species, as an anti-

275 itoyl-oleoyl-phosphatidylglycerol (POPG) and phosphatidylinositol (PI), antagonize the cognate ligand

276 holine (PC), phosphatidyl-ethanolamine (PE), phosphatidylinositol (PI), phosphatidylserine (PS), and

277 It is unclear how phosphatidylinositol (PI), the precursor of polyphosphoi

278 ely charged lipids, with elevated amounts of phosphatidylinositol (PI), were also present.

279 are derived from the major structural lipid, phosphatidylinositol (PI).

280 ine (PC), phosphatidylethanolamine (PE), and phosphatidylinositol (PI).

281 The class III phosphatidylinositol (PI)3-kinase complexes I and II (PI

282 , with high amounts of phosphatidylcholines, phosphatidylinositols (PI) and cholesterol.

283 nolamines (PE), lactosylceramides (LCER) and phosphatidylinositols (PI) were also detected in the BM

284 rated phospholipids (PUFA-PLs), specifically phosphatidylinositol (-PI) lipids linked to lethal infla

285 anes, it phosphorylates its substrate lipid (phosphatidylinositol, PI) to generate the essential sign

286 e proteins both potentiate the activities of phosphatidylinositol (PtdIns) 4-OH kinases and help chan

287 that the VAP-interacting membrane-associated phosphatidylinositol (PtdIns) transfer proteins PYK2 N-t

288 We identified 1-stearoyl-2-arachidonoyl-phosphatidylinositol (SAPI), which is the most abundant

289 sitol polyphosphates and participates in the phosphatidylinositol signaling pathway.

290 serves as a regulatory component to connect phosphatidylinositol signaling to F-actin polymerization

291 as myosin-1, serve as key molecules to link phosphatidylinositol signals to podosome assembly.

292 l strength by generating different levels of phosphatidylinositol species that engage alternate signa

293 TCR signal strength differentially generates phosphatidylinositol species.

294 pore-forming toxin listeriolysin O (LLO) and phosphatidylinositol-specific phospholipase C (PI-PLC).

295 Sfh5 is an unusual member of the Sec14-like phosphatidylinositol transfer protein (PITP) family.

296 Ps) and phosphatidic acid (PA) and acts as a phosphatidylinositol transfer protein in vitro, and expr

297 Here, we found that the phosphatidylinositol transfer protein Nir2 acts as an LT

298 In addition, we identify the phosphatidylinositol transfer protein Nir2 as an effecto

299 SEC14-like phosphatidylinositol transfer proteins (SEC14L-PITPs) pr

300 Phosphatidylinositol-transfer proteins (PITPs) are key r