ライフサイエンスコーパス: phosphatidylinositol 3-phosphate

1 by a GFP-tagged 2xFYVE protein that binds to phosphatidylinositol 3-phosphate.

2 ts FYVE (Fab1p, YOTB, Vac1p, EEA1) domain to phosphatidylinositol 3-phosphate.

3 functional and that binding is specific for phosphatidylinositol 3-phosphate.

4 n binds with high specificity and avidity to phosphatidylinositol 3-phosphate.

5 Vps15 and stimulates increased production of phosphatidylinositol 3-phosphate.

6 imulated the activity of PI3K as measured by phosphatidylinositol 3-phosphate.

7 m-1 to abolish its weak, specific binding to phosphatidylinositol 3-phosphate.

8 domain that has recently been shown to bind phosphatidylinositol 3-phosphate.

9 multiple negative charges such as citrate or phosphatidylinositol 3-phosphate.

10 holipid bilayer can abet specific binding to phosphatidylinositol 3-phosphate.

11 strates phosphatidylinositol 4-phosphate and phosphatidylinositol 3-phosphate.

12 tein known (in any context) to interact with phosphatidylinositol 3-phosphate.

13 gets 3-position phosphoinositides, including phosphatidylinositol 3-phosphate.

14 required an intact FYVE domain, which binds phosphatidylinositol 3-phosphate.

15 CP1 is an ER-resident molecule that binds to phosphatidylinositol 3-phosphate.

16 ty was determined by measuring production of phosphatidylinositol-3-phosphate.

17 s involved in autophagy initiation, and bind phosphatidylinositol-3-phosphate.

18 complexes responsible for the generation of phosphatidylinositol-3-phosphate.

19 tidylinositols such as phosphatidylinositol, phosphatidylinositol 3-phosphate, 4-phosphate, 5-phospha

20 lization and degradation requires binding to phosphatidylinositol 3-phosphate 5-kinase (PIKfyve), a l

21 The activated Akt acted through phosphatidylinositol 3-phosphate 5-kinase and Rab11 to f

22 The Fab1 protein is a phosphatidylinositol 3-phosphate 5-kinase involved in ye

23 We had previously shown that Fab1 phosphatidylinositol 3-phosphate 5-kinase is also requir

24 e (PtdIns(3,5)P2) is synthesized by a single phosphatidylinositol 3-phosphate 5-kinase, Fab1.

25 genomics screen that unexpectedly identified Phosphatidylinositol-3-phosphate 5 kinase (PIKfyve) as a

26 cell lines that identified the lipid kinase phosphatidylinositol-3-phosphate 5-kinase (PIKfyve) as a

27 ly potent and cell-active chemical probe for phosphatidylinositol-3-phosphate 5-kinase (PIKfyve), SGC

28 ell-active chemical probe (17) that inhibits phosphatidylinositol-3-phosphate 5-kinase (PIKfyve).

29 te 5-kinase, its3p, but does not require the phosphatidylinositol-3-phosphate 5-kinase, fab1p.

30 Leucettine L41 modestly inhibited phosphatidylinositol-3-phosphate 5-kinase, FYVE domain-c

31 I PI3K Vps34, while PI(3,5)P(2) requires the phosphatidylinositol-3-phosphate-5-kinase PIKFYVE.

32 he lack of Vps34p resulted in the absence of phosphatidylinositol 3-phosphate, a lipid required for S

33 14/PI3KIII complex in regard to synthesis of phosphatidylinositol 3-phosphate, a process that is link

34 Endosomal traffic is largely controlled by phosphatidylinositol-3-phosphate, a phosphoinositide syn

35 responsible for inducing the accumulation of phosphatidylinositol-3-phosphate, a regulator of both NO

36 othesis that targeted hyperactivation of the phosphatidylinositol-3-phosphate/AKT (PI3K/AKT)-signalin

37 eases in the potential products of 5PTase11, phosphatidylinositol (3) phosphate and phosphatidylinosi

38 tive binding to the endosomal membrane lipid phosphatidylinositol 3-phosphate and assembles an AKT si

39 in a diminishment of localized generation of phosphatidylinositol 3-phosphate and blockade of both en

40 These findings define the generation of phosphatidylinositol 3-phosphate and EEA1 recruitment as

41 t MTMR7 dephosphorylated the D-3 position of phosphatidylinositol 3-phosphate and inositol 1,3-bispho

42 ms a complex with MTMR9 and dephosphorylates phosphatidylinositol 3-phosphate and Ins(1,3)P2 in neuro

43 acting protein (WIPI)2, a protein that binds phosphatidylinositol 3-phosphate and its product phospha

44 tion, the central region mediated binding to phosphatidylinositol 3-phosphate and other phosphoinosit

45 sphorylated phosphatidylinositols (including phosphatidylinositol 3-phosphate and phosphatidylinosito

46 direct measurement of increases in cellular phosphatidylinositol 3-phosphate and phosphatidylinosito

47 PIKfyve binds to phosphatidylinositol 3-phosphate and synthesizes phospha

48 ity through a functional interaction between phosphatidylinositol 3-phosphate and the Phox homology (

49 we targeted PTEN, an enzyme that hydrolyzes phosphatidylinositol 3-phosphate and thereby prevents AK

50 is the result of interactions of Vps27 with phosphatidylinositol 3-phosphate and ubiquitin.

51 zinc finger domain, which specifically binds phosphatidylinositol(3)-phosphate and is conserved in se

52 ins a phox homology domain predicted to bind phosphatidylinositol-3-phosphate and a C-terminal coiled

53 5-biphosphate marks the plasma membrane, and phosphatidylinositol-3-phosphate and phosphatidylinosito

54 in, an enzyme specifically dephosphorylating phosphatidylinositol-3-phosphate and phosphatidylinosito

55 Our data demonstrate that H7 binds phosphatidylinositol-3-phosphate and phosphatidylinosito

56 of phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3-phosphate, and phosphatidic acid

57 represents a bifunctional protein with both phosphatidylinositol 3-phosphate- and arabinogalactan pr

58 linositol (3,5)-bisphosphate and decrease in phosphatidylinositol 3-phosphate] and up-regulation of m

59 mmediate autophagic response, accompanied by phosphatidylinositol-3-phosphate appearance at the ER me

60 By metabolic labeling, we here identify phosphatidylinositol 3-phosphate as the sole in vivo pro

61 Here, we explored Phytophthora-derived PI3P (phosphatidylinositol 3-phosphate) as a novel control tar

62 kinase (also known as Vps34) and its product phosphatidylinositol-3-phosphate, as well as on the lipi

63 This defect reduces the phosphatidylinositol 3-phosphate binding affinity of Cb,

64 studies therefore indicate that low affinity phosphatidylinositol 3-phosphate binding by the C-termin

65 increased IgA production dependent upon its phosphatidylinositol 3-phosphate binding domain.

66 hly conserved small GTPases, Gtr1/2, and the phosphatidylinositol 3-phosphate binding protein, Pib2.

67 docytic pathway and the number of accessible phosphatidylinositol 3-phosphate binding sites they cont

68 The phosphatidylinositol 3-phosphate binding, FYVE domain-co

69 ntains only 12 genes predicted to encode for phosphatidylinositol 3-phosphate binding, FYVE domain-co

70 ATG18 is a phosphatidylinositol-3-phosphate binding protein essenti

71 TyA-GFP to endosome membranes by fusion to a phosphatidylinositol 3-phosphate-binding domain induced

72 n phosphatidylinositol 3-kinase activity and phosphatidylinositol 3-phosphate-binding effectors.

73 cruited to the phagophore by a subset of the phosphatidylinositol 3-phosphate-binding seven-bladedB -

74 ws how anionic ligands can interact with the phosphatidylinositol 3-phosphate-binding site.

75 a synthetic interaction via competition for phosphatidylinositol 3-phosphate-binding sites with endo

76 nuclear receptor-like fingers, LIM domains, phosphatidylinositol-3-phosphate-binding domains and His

77 We also identify FYVE1, a phosphatidylinositol-3-phosphate-binding protein recruit

78 Phosphatidylinositol 3-phosphate binds to a pocket forme

79 es is blocked by inhibition of fatty acid or phosphatidylinositol-3-phosphate biosynthesis, and the f

80 ibition of PI3KC2alpha-mediated synthesis of phosphatidylinositol 3-phosphates by PITCOINs impairs en

81 gnaling and membrane-trafficking proteins to phosphatidylinositol 3-phosphate-containing endosomes, e

82 In addition to establishing phosphatidylinositol-3-phosphate deficiency as a contrib

83 horylation of Thr-252 in vitro by the enzyme phosphatidylinositol 3-phosphate-dependent kinase-1 or m

84 Phosphatidylinositol 3-phosphate directs the endosomal l

85 tely after budding coincides with a burst of phosphatidylinositol-3-phosphate, distinct from any late

86 onto the membrane in three steps by (i) the phosphatidylinositol 3-phosphate effector protein WD rep

87 quired for Transport) pathway, including the phosphatidylinositol-3-phosphate effector Hrs and Tsg101

88 of a sorting nexin (SNX) dimer that binds to phosphatidylinositol 3-phosphate-enriched endosomal memb

89 he phox (PX) domain of Snx 17 interacts with phosphatidylinositol-3-phosphate for membrane associatio

90 by accumulation of the MTMR substrate lipid phosphatidylinositol 3-phosphate generated from the type

91 3,4,5-trisphosphate (PtdIns-(3,4,5)P(3)) >> phosphatidylinositol 3-phosphate > phosphatidylinositol

92 To begin to address the function of phosphatidylinositol 3-phosphate in skeletal muscle, we

93 65Q mutant, which has decreased affinity for phosphatidylinositol 3-phosphate in vitro, fails to targ

94 ard the vacuole of structures labeled by the phosphatidylinositol 3-phosphate indicator YFP-2xFYVE.

95 Here we show that phosphatidylinositol-3-phosphate is selectively deficien

96 inositides, Tiam1 selectively interacts with phosphatidylinositol 3-phosphate (K(D) approximately 5-1

97 ng MAP kinases, insulin receptor substrates, phosphatidylinositol 3' phosphate kinase, diacylglycerol

98 Phosphatidylinositol 3-phosphate kinase activity was als

99 Phosphatidylinositol 3-phosphate kinase and Akt activiti

100 Both phosphatidylinositol 3-phosphate kinase and caveolin-1 w

101 tivities were also induced by C5b-9, and the phosphatidylinositol 3-phosphate kinase inhibitor LY2940

102 Here, we report on the role of the class II phosphatidylinositol 3-phosphate kinase PIK3C2A in S. fl

103 g (PTEN), the main negative regulator of the phosphatidylinositol 3-phosphate kinase/Akt pathway, are

104 rsed with LY294002 or wortmannin, suggesting phosphatidylinositol-3-phosphate kinase (PI3K) dependenc

105 however, diploids exhibit resistance to the phosphatidylinositol-3-phosphate kinase inhibitor wortma

106 evels, thereby restricting activation of the phosphatidylinositol-3-phosphate kinase pathway and prom

107 Inhibition of phosphatidylinositol-3-phosphate kinase, an upstream act

108 active beta1-integrins rather than rescue of phosphatidylinositol 3-phosphate levels underlies the ab

109 KO and Mtm1 p.R69C mice have similar muscle phosphatidylinositol 3-phosphate levels.

110 f2 deficiency led to increased intracellular phosphatidylinositol-3 phosphate levels and diminished A

111 , a chimeric protein that specifically binds phosphatidylinositol 3-phosphate, localizes to the trypa

112 uires the activity of Vps34, suggesting that phosphatidylinositol(3)phosphate may be essential for th

113 ncreasingly clarified, the normal role(s) of phosphatidylinositol 3-phosphate metabolism in muscle de

114 X19 to the ER, and a PX domain that binds to phosphatidylinositol 3-phosphate on the endolysosomal me

115 NX2 protein as did the overexpression of the phosphatidylinositol 3-phosphate phosphatase, confirming

116 n of dominant-negative PI3K (DN-p85alpha) or phosphatidylinositol 3-phosphate-phosphatase, PTEN, also

117 ot phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3-phosphate, phosphatidylinositol,

118 ll-molecule inhibitors of the main endosomal phosphatidylinositol-3-phosphate/phosphatidylinositol 5-

119 sitide-3-phosphatases, which dephosphorylate phosphatidylinositol 3-phosphate (PI(3)P) and bisphospha

120 Autophagosome formation is known to require phosphatidylinositol 3-phosphate (PI(3)P) and occurs nea

121 e report here that the stepwise formation of phosphatidylinositol 3-phosphate (PI(3)P) and phosphatid

122 Phosphatidylinositol 3-phosphate (PI(3)P) and phosphatid

123 dentified the phosphoinositide lipids (PIPs) phosphatidylinositol 3-phosphate (PI(3)P) and phosphatid

124 , has an N-terminal PX domain which binds to phosphatidylinositol 3-phosphate (PI(3)P) and to HOPS an

125 nner that depended on its FYVE domain and on phosphatidylinositol 3-phosphate (PI(3)P) biosynthesis.

126 ically dephosphorylate at the D3 position of phosphatidylinositol 3-phosphate (PI(3)P) in PI(3)P and

127 Phosphatidylinositol 3-phosphate (PI(3)P) levels in Plas

128 3, with a relative potency of PI(3,4,5)P3 >> phosphatidylinositol 3-phosphate (PI(3)P) or phosphatidy

129 phoinositide 3-kinase Vps34, suggesting that phosphatidylinositol 3-phosphate (PI(3)P) plays a role i

130 Phosphatidylinositol 3-phosphate (PI(3)P) plays an impor

131 Mtm-mediated turnover of endosomal phosphatidylinositol 3-phosphate (PI(3)P) pools generate

132 Invaginations are stabilized by phosphatidylinositol 3-phosphate (PI(3)P) produced by th

133 recruits the VPS34 component VPS15, enabling phosphatidylinositol 3-phosphate (PI(3)P) synthesis on n

134 a MTM pseudophosphatase Sbf coordinates both phosphatidylinositol 3-phosphate (PI(3)P) turnover and R

135 Most FYVE domains bind specifically to phosphatidylinositol 3-phosphate (PI(3)P), a lipid that

136 bularin utilizes the lipid second messenger, phosphatidylinositol 3-phosphate (PI(3)P), as a physiolo

137 YFP-2xFYVE, recognizing phosphatidylinositol 3-phosphate (PI(3)P), showed two pa

138 p7p/Vps19p, associates with Pep12p and binds phosphatidylinositol 3-phosphate (PI(3)P), the product o

139 Phosphatidylinositol 3-phosphate (PI(3)P), the product o

140 along microtubules, tethered to vesicles via phosphatidylinositol 3-phosphate (PI(3)P), the signature

141 t RME-8 associates with early endosomes in a phosphatidylinositol 3-phosphate (PI(3)P)-dependent fash

142 ased CPTP transfer activity, whereas others (phosphatidylinositol 3-phosphate (PI-3P) and PI) did not

143 Finally, we show that the conserved phosphatidylinositol-3-phosphate (PI(3)P) binding protei

144 A recent study reported that phosphatidylinositol-3-phosphate (PI(3)P) concentrated i

145 cilitates export by recognition of the lipid phosphatidylinositol-3-phosphate (PI(3)P) in the ER, pri

146 assays revealed that RavD selectively binds phosphatidylinositol-3-phosphate (PI(3)P) in vitro We fu

147 Phosphatidylinositol-3-phosphate (PI(3)P) is a key regul

148 5-trisphosphate were below detection limits, phosphatidylinositol-3-phosphate (PI(3)P) levels in rod

149 Here we report that a conversion of phosphatidylinositol-3-phosphate (PI(3)P) to phosphatidy

150 tively, along with a PX domain that binds to phosphatidylinositol-3-phosphate (PI(3)P), which is gene

151 nd WIPI2, belong to a WD40 repeat-containing phosphatidylinositol-3-phosphate (PI(3)P)-binding protei

152 EA1 binds endosomal membranes, which contain phosphatidylinositol-3-phosphate (PI(3)P).

153 uired to maintain normal endosomal levels of phosphatidylinositol-3-phosphate (PI(3)P).

154 lcholine/phosphatidylinositol monophosphate (phosphatidylinositol-3-phosphate (PI-3P), -4-phosphate (

155 These findings indicate that phosphatidylinositol-3-phosphate (PI[3]P) is required fo

156 s nanomolar affinity for bilayers containing phosphatidylinositol-3-phosphate (PI[3]P).

157 curved membranes, but not flat ones, can use phosphatidylinositol 3-phosphate [PI(3)P] along with pho

158 the HOPS complex), and 2 phosphoinositides, phosphatidylinositol 3-phosphate [PI(3)P] and phosphatid

159 ases that dephosphorylate the 3' position of phosphatidylinositol 3-phosphate [PI(3)P] and PI(3,5)P(2

160 d its recruitment to the endosome depends on phosphatidylinositol 3-phosphate [PI(3)P] and the Rab5 G

161 y represses the synthesis of endosomal lipid phosphatidylinositol 3-phosphate [PI(3)P] by the lipid k

162 Binding of the lipid phosphatidylinositol 3-phosphate [PI(3)P] is a critical

163 We found that yeast mutants lacking the phosphatidylinositol 3-phosphate [PI(3)P] kinase Vps34 o

164 The lipid second messenger phosphatidylinositol 3-phosphate [PI(3)P] plays a crucia

165 d phosphatidylinositol 4-phosphate [PI(4)P], phosphatidylinositol 3-phosphate [PI(3)P], and the lipid

166 ity of PX domains bind with high affinity to phosphatidylinositol 3-phosphate [PI(3)P], whereas the m

167 tophagy pathways, which are characterized by phosphatidylinositol 3-phosphate [PI(3)P]-positive membr

168 he KCa3.1 channel also specifically requires phosphatidylinositol-3 phosphate [PI(3)P] for channel ac

169 sed assay also showed stimulatory effects by phosphatidylinositol-3-phosphate [PI(3)P] and ergosterol

170 is due to the HT signal binding to the lipid phosphatidylinositol-3-phosphate [PI(3)P] in the parasit

171 nt of phosphatidylethanolamine phospholipid, phosphatidylinositol-3-phosphate [PI(3)P], and phosphati

172 The synthesis and recognition of the lipid phosphatidylinositol 3-phosphate, PI(3)P, is essential f

173 of downstream target proteins: Raf kinases, phosphatidylinositol-3 phosphate (PI3) kinase, and Ral-s

174 activates several kinase cascades, including phosphatidylinositol 3-phosphate (PI3K)/Akt, a signaling

175 While the role of phosphatidylinositol 3-phosphate (PI3P) and phosphatidyl

176 urs by coincidence detection, requiring both phosphatidylinositol 3-phosphate (PI3P) and Rag GTPases.

177 le (AV) biogenesis through the generation of phosphatidylinositol 3-phosphate (PI3P) and the recruitm

178 erminal PX domain of Vam7 binds to the lipid phosphatidylinositol 3-phosphate (PI3P) and the tetherin

179 ts abrogate binding to its cognate substrate phosphatidylinositol 3-phosphate (PI3P) and thus prevent

180 of retromer to endosomes requires the lipid phosphatidylinositol 3-phosphate (PI3P) as well as Rab5

181 Filimonenko et al. provide evidence that the phosphatidylinositol 3-phosphate (PI3P) binding protein,

182 n strains vps34Delta and vps15Delta, lacking phosphatidylinositol 3-phosphate (PI3P) biosynthesis, al

183 PI(3,5)P2 is generated from phosphatidylinositol 3-phosphate (PI3P) by the lipid kin

184 the process, specifically for Vps34-mediated phosphatidylinositol 3-phosphate (PI3P) deposition.

185 protein kinase activated by the phospholipid phosphatidylinositol 3-phosphate (PI3P) downstream of gr

186 nramp4 Our results indicate that AtPH1 binds phosphatidylinositol 3-phosphate (PI3P) in vivo and acts

187 Phosphatidylinositol 3-phosphate (PI3P) is a key ligand

188 y negative regulatory role in autophagy of a phosphatidylinositol 3-phosphate (PI3P) phosphatase Jump

189 Phosphatidylinositol 3-phosphate (PI3P), a membrane traf

190 ysosomes, the existence of cyclical waves of phosphatidylinositol 3-phosphate (PI3P), a membrane traf

191 o bind with high affinity and specificity to phosphatidylinositol 3-phosphate (PI3P), a phosphoinosit

192 and poly-PR-expressing neurons by elevating phosphatidylinositol 3-phosphate (PI3P), accompanied by

193 w that Vps13 binds phospholipids, especially phosphatidylinositol 3-phosphate (PI3P), via its SHR_BD

194 VPS34 produces phosphatidylinositol 3-phosphate (PI3P), which is the su

195 zing the paramagnetic restraints obtained in phosphatidylinositol 3-phosphate (PI3P)-enriched micelle

196 (ATG2), the rod-shaped protein that tethers phosphatidylinositol 3-phosphate (PI3P)-enriched phagoph

197 AnkB associates with phosphatidylinositol 3-phosphate (PI3P)-positive organel

198 e fusion) and has Phox homology, providing a phosphatidylinositol 3-phosphate (PI3P)-specific membran

199 rect binding to phosphoinositides, including phosphatidylinositol 3-phosphate (PI3P).

200 ergosterol (ERG), diacylglycerol (DAG), and phosphatidylinositol 3-phosphate (PI3P).

201 cs that are highly specialized with abundant phosphatidylinositol 3-phosphate (PI3P).

202 itol 3-kinase (VPS34) specifically increases phosphatidylinositol 3-phosphate (PI3P).

203 of Cb binds phosphoinositides, specifically phosphatidylinositol 3-phosphate (PI3P).

204 s, presumably by preventing the formation of phosphatidylinositol 3-phosphate (PI3P).

205 atidylinositol 3-kinase Vps34, and the lipid phosphatidylinositol 3-phosphate (PI3P).

206 We have previously shown phosphatidylinositol-3-phosphate (PI3P) accumulation in

207 selectively binds the membrane phospholipid phosphatidylinositol-3-phosphate (PI3P) and is important

208 r viral replication and for binding of H7 to phosphatidylinositol-3-phosphate (PI3P) and phosphatidyl

209 vestigation identified the EE membrane lipid phosphatidylinositol-3-phosphate (PI3P) as a link betwee

210 t this hypothesis, we elevated the levels of phosphatidylinositol-3-phosphate (PI3P) by generating hy

211 The lipid phosphatidylinositol-3-phosphate (PI3P) is a regulator o

212 Here, we identified that phosphatidylinositol-3-phosphate (PI3P) mediates Arc cap

213 date that the viral protein 3 (VP3) binds to phosphatidylinositol-3-phosphate (PI3P) present in EE me

214 s stimulated by p40(phox) and its binding to phosphatidylinositol-3-phosphate (PI3P), a phosphoinosit

215 otal syntheses of phosphatidylinositol (PI), phosphatidylinositol-3-phosphate (PI3P), phosphatidylino

216 R motifs enable binding to the phospholipid, phosphatidylinositol-3-phosphate (PI3P).

217 I) to generate the essential signaling lipid phosphatidylinositol-3-phosphate (PI3P).

218 of the kinase, as well as its lipid product phosphatidylinositol-3-phosphate (PI3P).

219 Cdt functioned both as a DNase and a phosphatidylinositol 3-phosphate (PIP(3)) phosphatase, a

220 dylinositol 3'-kinase (PI 3-kinase) produces phosphatidylinositol 3'-phosphates, plays a critical rol

221 In the presence of phosphatidylinositol 3-phosphate, polymerization is both

222 , distinct from any later encounter with the phosphatidylinositol-3-phosphate pool in early endosomes

223 fferent vesicle maturation stages shows that phosphatidylinositol 3-phosphate production precedes fus

224 d such that the VPS34 lipid kinase catalyzes phosphatidylinositol-3 phosphate production on membranes

225 which, when expressed alone, interacts with phosphatidylinositol 3-phosphate (PtdIns (3)P).

226 Phosphatidylinositol 3-phosphate (PtdIns(3)P) is a phosp

227 Phosphatidylinositol 3-phosphate (PtdIns(3)P) is a signa

228 tions with both the dynactin subunit p62 and phosphatidylinositol 3-phosphate (PtdIns(3)P) lipids gen

229 We provide evidence that Phosphatidylinositol 3-Phosphate (PtdIns(3)P) regulates

230 autophagy by endoplasmic reticulum-localized phosphatidylinositol 3-phosphate (PtdIns(3)P) synthesis.

231 Tollip preferentially binds phosphatidylinositol 3-phosphate (PtdIns(3)P) via its C2

232 re, we examined the relationship between the phosphatidylinositol 3-phosphate (PtdIns(3)P)-binding ab

233 n membrane trafficking and cell signaling to phosphatidylinositol 3-phosphate (PtdIns(3)P)-containing

234 s, we found that the p40(phox) PX domain has phosphatidylinositol 3-phosphate (PtdIns(3)P)-dependent

235 nserved cell renewal process that depends on phosphatidylinositol 3-phosphate (PtdIns(3)P).

236 ia a phox homology (PX) domain that binds to phosphatidylinositol 3-phosphate (PtdIns(3)P).

237 ruited to endosomes through interaction with phosphatidylinositol 3-phosphate (PtdIns(3)P).

238 FYVE domain that interacts specifically with phosphatidylinositol 3-phosphate (PtdIns-3-P) and a Rab5

239 at certain PX domains specifically recognize phosphatidylinositol 3-phosphate (PtdIns-3-P) and drive

240 and have been shown to bind specifically to phosphatidylinositol 3-phosphate (PtdIns-3-P).

241 TECPR1 binds to the Atg12-Atg5 conjugate and phosphatidylinositol 3-phosphate (PtdIns[3]P) to promote

242 ruited to endosomal membranes via binding to phosphatidylinositol 3-phosphate (PtdIns[3]P).

243 and is required for endosomal generation of phosphatidylinositol-3-phosphate (PtdIns(3)P) and recrui

244 singly, the regulatory early endosomal lipid phosphatidylinositol-3-phosphate (PtdIns(3)P) persists o

245 This was mediated through stimulation of phosphatidylinositol-3-phosphate (PtdIns(3)P) production

246 w metabolically stabilized (ms) analogues of phosphatidylinositol-3-phosphate (PtdIns(3)P) were synth

247 Similarly, the role of phosphatidylinositol-3-phosphate (PtdIns-3-P) as an intr

248 Phosphatidylinositol-3-phosphate (PtdIns-3-P) is conside

249 motifs can bind phospholipids, specifically phosphatidylinositol-3-phosphate (PtdIns-3-P).

250 omyces cerevisiae FAB1 gene encodes the sole phosphatidylinositol 3-phosphate [PtdIns(3)P] 5-kinase r

251 ossess catalytic activity, dephosphorylating phosphatidylinositol 3-phosphate [PtdIns(3)P] and phosph

252 membrane, and it favors membrane composed of phosphatidylinositol 3-phosphate [PtdIns(3)P] and phosph

253 2A expression was required for production of phosphatidylinositol 3-phosphate [PtdIns(3)P] at the pla

254 LtpD471-626 bound directly to phosphatidylinositol 3-phosphate [PtdIns(3)P] in vitro a

255 d signaling proteins to membranes containing phosphatidylinositol 3-phosphate [PtdIns(3)P] is mediate

256 Vps34 lipid kinase complex, which generates phosphatidylinositol 3-phosphate [PtdIns(3)P] on the for

257 ylinositol 3-kinase) complex and its product phosphatidylinositol 3-phosphate [PtdIns(3)P] play key r

258 Phagosome maturation requires phosphatidylinositol 3-phosphate [PtdIns(3)P], yet how P

259 ins a zinc-binding FYVE finger that may bind phosphatidylinositol 3-phosphate [PtdIns(3)P].

260 P3], accompanied by small quantities of [32P]phosphatidylinositol 3-phosphate [PtdIns(3)P].

261 The lipid kinase Fab1 converts phosphatidylinositol-3-phosphate [PtdIns(3)P] to PtdIns(

262 MTMR3 decreased PRR-induced phosphatidylinositol 3-phosphate (PtdIns3P) and autophag

263 ide (PI) 3-phosphatases that dephosphorylate phosphatidylinositol 3-phosphate (PtdIns3P) and PtdIns(3

264 ide (PI) 3-phosphatases that dephosphorylate phosphatidylinositol 3-phosphate (PtdIns3P) and PtdIns(3

265 g and by amino acid-stimulated production of phosphatidylinositol 3-phosphate (PtdIns3P) by the lipid

266 In contrast, phosphatidylinositol 3-phosphate (PtdIns3P) levels were

267 linositols (PIs) demonstrates that it is the phosphatidylinositol 3-phosphate (PtdIns3P) or its metab

268 ynthesis depends upon both the generation of phosphatidylinositol 3-phosphate (PtdIns3P), which is se

269 ABH binds with high affinity to phosphatidylinositol-3-phosphate (PtdIns3P) and cleaves

270 Specific recognition of phosphatidylinositol 3-phosphate [PtdIns3P] by the FYVE

271 Recognition of phosphatidylinositol 3-phosphate (Ptdlns(3)P) is crucial

272 Phosphatidylinositol 3-phosphate regulates membrane traf

273 everal vacuolar membrane constituents: HOPS, phosphatidylinositol 3-phosphate, SNAREs, and acidic pho

274 19 PX domains bind the early endosomal lipid phosphatidylinositol 3-phosphate, SNX14 shows no membran

275 lusion that the p40(phox) PX domain binds to phosphatidylinositol 3-phosphate specifically in vitro a

276 ulates Akt activation via a cellular pool of phosphatidylinositol 3-phosphate that is distinct from t

277 Here we identify a lysosomal pool of phosphatidylinositol 3-phosphate that, when depleted by

278 Remarkably, these kinases can convert phosphatidylinositol 3-phosphate to phosphatidylinositol

279 Conversely, SNAREs and actin regulate phosphatidylinositol 3-phosphate vertex enrichment.

280 7 and the endosomally enriched lipid species phosphatidylinositol 3-phosphate via the FYVE domain (Fa

281 cells, whereas levels of the PtdIns(4)P and phosphatidylinositol-3-phosphate were unchanged.

282 ion of the p40(phox) PX domain is induced by phosphatidylinositol 3-phosphate, whereas that of the p4

283 he PX domain of p40(phox) specifically binds phosphatidylinositol 3-phosphate, whereas the PX domain

284 psinogen activation causes a 75% decrease in phosphatidylinositol 3-phosphate, which is implicated in

285 of macrophages Slamf1 induces production of phosphatidylinositol 3-phosphate, which positively regul

286 lated state disrupts SNX17's ability to bind phosphatidylinositol-3-phosphate, which in turn impairs