ライフサイエンスコーパス: phosphatidylinositol 4,5-bisphosphate

1 sence and presence of phosphatidylserine and phosphatidylinositol 4,5-bisphosphate.

2 igh curvature strictly depends on binding to phosphatidylinositol 4,5-bisphosphate.

3 hosphatidic acid and boosts the synthesis of phosphatidylinositol 4,5-bisphosphate.

4 rn repeated for C2F domain interactions with phosphatidylinositol 4,5-bisphosphate.

5 2 phosphorylation and impaired metabolism of phosphatidylinositol 4,5-bisphosphate.

6 pids, capsaicin-induced activity depended on phosphatidylinositol 4,5-bisphosphate.

7 the membrane phospholipid signaling molecule phosphatidylinositol 4,5-bisphosphate.

8 lipase C, and it increased the hydrolysis of phosphatidylinositol 4,5-bisphosphate.

9 in, and treatment with neomycin to sequester phosphatidylinositol 4,5-bisphosphate.

10 ivity is promoted by G proteins that deplete phosphatidylinositol 4,5-bisphosphate.

11 dhesion of a pleckstrin homology domain with phosphatidylinositol 4,5-bisphosphate.

12 t increases substantially in the presence of phosphatidylinositol 4,5-bisphosphate.

13 converts phosphatidylinositol-5-phosphate to phosphatidylinositol-4,5-bisphosphate.

14 es the interactions with the signaling lipid phosphatidylinositol-4,5-bisphosphate.

15 a specific structure upon binding its ligand phosphatidylinositol-(4,5)-bisphosphate.

16 Gag through interaction with an acidic lipid phosphatidylinositol-(4,5)-bisphosphate.

17 ced YAP nuclear accumulation via the FAK-Src-phosphatidylinositol 4,5-bisphosphate 3-kinase (PI3K) si

18 rms that one important physiological signal, phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) ac

19 ound to be mediated at least in part through phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) ac

20 h encodes the catalytic subunit alpha of the phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) fr

21 tivation of spleen tyrosine kinase (Syk) and phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K).

22 the list of genes encoding components of the phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/AK

23 Phosphatidylinositol-4,5-bisphosphate 3-kinase 1A, activ

24 Akt/PKB, a key effector of phosphatidylinositol-4,5-bisphosphate 3-kinase 1A, was p

25 ential methylation of two replicated PIK3CD (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic

26 sequencing found a missense mutation in the Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic

27 Pik3cg, encoding phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic

28 ncers (CRCs) with oncogenic mutations in the phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic

29 intact signaling through the Janus Kinase 2/phosphatidylinositol-4,5-bisphosphate 3-kinase pathway.

30 Itk(-/-)Btk(-/-) mast cells, and blockage of phosphatidylinositol-4,5-bisphosphate 3-kinase, Akt, or

31 breast cancer bearing an activating PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase, catalyti

32 r receptor 2 (HER2; ERBB2) amplification and phosphatidylinositol-4,5-bisphosphate 3-kinase, catalyti

33 e included an activating mutation in PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase, catalyti

34 IAM1 to the membrane require the activity of phosphatidylinositol-4,5-bisphosphate 3-kinase.

35 ivation of canonical nuclear factor kappa B, phosphatidylinositol-4,5-bisphosphate 3-kinase/Akt, and

36 The phosphatidylinositol-4,5-bisphosphate 3-kinase/Akt/ mamm

37 Although phosphatidylinositol 4,5-bisphosphate, 3-phosphate, and

38 Postzygotic somatic mutations activating the phosphatidylinositol-4,5-bisphosphate-3-kinase (PI3K)-pr

39 VEGFR2 interacts with phosphatidylinositol-4,5-bisphosphate-3-kinase and AKT t

40 We found VEGFR2 to activate phosphatidylinositol-4,5-bisphosphate-3-kinase and AKT,

41 Septin filaments and phosphatidylinositol-4,5-bisphosphate (also known as Ptd

42 r reorientation, while depleting the pool of phosphatidylinositol-4,5-bisphosphate, an activator of m

43 er by the presence of phospholipid vesicles, phosphatidylinositol 4,5-bisphosphate and Ca(2+), or by

44 iven by the plasma membrane phosphoinositide phosphatidylinositol 4,5-bisphosphate and cargo relieves

45 NCX inactivation occurs in the absence of phosphatidylinositol 4,5-bisphosphate and is facilitated

46 kers for the anionic signaling phospholipids phosphatidylinositol 4,5-bisphosphate and phosphatidic a

47 this regard, phosphoinositides, particularly phosphatidylinositol 4,5-bisphosphate and phosphatidylin

48 shuttles two lipid second messengers, i.e., phosphatidylinositol 4,5-bisphosphate and phosphatidylin

49 ortical granule exocytosis, the elevation of phosphatidylinositol 4,5-bisphosphate and the large, lat

50 ne and occurs following its interaction with phosphatidylinositol-(4,5)-bisphosphate and its subseque

51 taining 2 mol % 1,2-dipalmitoyl-sn-glycero-3-phosphatidylinositol-4,5-bisphosphate and Atto488-1,2-di

52 branes containing the annexin binding lipids phosphatidylinositol-4,5-bisphosphate and phosphatidylse

53 odomains, which are enriched in cholesterol, phosphatidylinositol 4,5-bisphosphate, and gangliosidic

54 e cation channel activated by cold, voltage, phosphatidylinositol 4,5-bisphosphate, and menthol.

55 d protein kinase, the signaling phospholipid phosphatidylinositol-(4, 5)-bisphosphate, and the c-Abl-

56 sphate (PIP3) signaling and converts PIP3 to phosphatidylinositol (4,5)-bisphosphate at the plasma me

57 otentiated by cold temperature involving the phosphatidylinositol 4,5-bisphosphate binding residue (L

58 ge-sensing domain, and about cold sensor and phosphatidylinositol 4,5-bisphosphate binding sites, whi

59 ) input, including motifs for calmodulin and phosphatidylinositol 4,5-bisphosphate binding, protein k

60 ary to localize the -amine of Lys-170 in the phosphatidylinositol 4,5-bisphosphate-binding site.

61 Our results further indicate conserved phosphatidylinositol 4,5-bisphosphate-binding sites in t

62 rotein (GFP)-Myo1c mutants revealed that the phosphatidylinositol-4,5-bisphosphate-binding site is ne

63 ale reorganization of phosphatidylserine and phosphatidylinositol 4,5-bisphosphate but not other anio

64 yoblast fusion depended on dynamin activity, phosphatidylinositol(4,5)bisphosphate content, and cell

65 We show that phosphatidylinositol 4,5-bisphosphate-dependent FGF2 oli

66 nventional secretory mechanism that involves phosphatidylinositol 4,5-bisphosphate-dependent insertio

67 leaflet of plasma membranes that may control phosphatidylinositol 4,5-bisphosphate-dependent membrane

68 Here, we show that phosphatidylinositol 4,5-bisphosphate-dependent membrane

69 ivates p75NTR to induce a Rac1-dependent and phosphatidylinositol 4,5-bisphosphate-dependent signalin

70 orrelating with the drug's ability to induce phosphatidylinositol 4,5-bisphosphate depletion after ag

71 nding to KCNQ2 channel, caused resistance to phosphatidylinositol 4,5-bisphosphate depletion, and inc

72 S4 movement and gate opening by mutations or phosphatidylinositol 4,5-bisphosphate depletion, we show

73 re due to the differences in plasma membrane phosphatidylinositol 4,5-bisphosphate depletion.

74 , an endosome-localized enzyme that produces phosphatidylinositol 4,5-bisphosphate, directly interact

75 Thus, although cholesterol and phosphatidylinositol 4,5-bisphosphate do not interact wi

76 move laterally across the plasma membrane to phosphatidylinositol (4,5)-bisphosphate-enriched domains

77 penetrate in trans to a membrane containing phosphatidylinositol 4,5 bisphosphate, even if phosphati

78 intact F-actin architecture is required for phosphatidylinositol 4,5-bisphosphate homeostasis mediat

79 increases phospholipase C activity, causing phosphatidylinositol 4,5-bisphosphate hydrolysis and ino

80 r bradykinin-induced M-current inhibition or phosphatidylinositol 4,5-bisphosphate hydrolysis.

81 ion displaces ciliary Inpp5e and accumulates phosphatidylinositol 4,5-bisphosphate in distal cilia.

82 in the surrounding membrane, including PIP2 (phosphatidylinositol-4,5-bisphosphate) in the inner leaf

83 beta1 activity measured with the fluorescent phosphatidylinositol 4,5-bisphosphate/inositol 1,4,5-tri

84 AT1508 is an allosteric modulator of channel-phosphatidylinositol 4,5-bisphosphate interactions.

85 phospholipase C (PLC) isozymes to hydrolyze phosphatidylinositol 4,5-bisphosphate into the second me

86 Phospholipase C (PLC) enzymes convert phosphatidylinositol-4,5-bisphosphate into the second me

87 membrane, where receptors are activated and phosphatidylinositol-4,5-bisphosphate is concentrated.

88 Specific binding of ENTH to phosphatidylinositol 4,5-bisphosphate leads to a substan

89 PIPKIgamma activity and, thereby, modulates phosphatidylinositol (4,5)-bisphosphate levels and adhes

90 ds of an I-BAR domain, we find clustering of phosphatidylinositol 4,5-bisphosphate-like lipids that i

91 When we include phosphatidylinositol 4,5-bisphosphate-like lipids that p

92 Upon binding to the phosphatidylinositol 4,5-bisphosphate lipid, the wild-ty

93 uration to membranes containing PS even if a phosphatidylinositol 4,5 bisphosphate membrane is presen

94 Neurites induce formation of plasma membrane phosphatidylinositol 4,5-bisphosphate microdomains at na

95 rings were initiated by a circular array of phosphatidylinositol(4,5)bisphosphate microdomains, and

96 red filaments on lipid monolayers containing phosphatidylinositol-4,5-bisphosphate, mimicking presenc

97 In addition, we observe a phosphatidylinositol-4,5-bisphosphate molecule forming a

98 Each GABA(A) receptor pentamer contains two phosphatidylinositol-4,5-bisphosphate molecules, the hea

99 phatase activity toward the phosphoinositide phosphatidylinositol (4,5)-bisphosphate or altered the s

100 The latter was due to accumulation of phosphatidylinositol 4,5-bisphosphate PI(4,5)P2 in endol

101 The phosphatidylinositol (4,5) bisphosphate (PI(4,5)P2) head

102 interaction of ExoU with soluble analogs of phosphatidylinositol (4,5)-bisphosphate (PI(4,5)P(2)).

103 (3,4,5)-trisphosphate (PI(3,4,5)P3) to form phosphatidylinositol (4,5)-bisphosphate (PI(4,5)P2).

104 Eisosomes promote hydrolysis of phosphatidylinositol 4,5 bisphosphate (PI(4,5)P2) by fun

105 yn with the acidic phosphoinositides (PIPs), phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)) and

106 Many actin-regulatory proteins interact with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)) and

107 we show that Flower Ca(2+) channel-dependent phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)) comp

108 utative second messengers, change in pH, and phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)) depl

109 the effects of Ca(2+), calmodulin (CaM), and phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)) in e

110 phate-mediated Ca(2+) release by hydrolyzing phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)) in t

111 osphoinositides and the other explaining how phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)) infl

112 Since phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)) main

113 by the Galphaq/phospholipase Cbeta (PLCbeta)/phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)) sign

114 RTKs can hydrolyze phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)) with

115 lysosomes, whereas PI 4-phosphates, such as phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)), are

116 terminal myristoylated matrix (MA) domain to phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)).

117 to the plasma membrane (PM), where it binds phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) and di

118 Weak TCR signals generated elevated phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) and re

119 CAPS binds phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) and SN

120 Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) has be

121 Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) is a m

122 Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) is a n

123 Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) is a v

124 Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) reside

125 s recently found to bind to the phospholipid phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), a mar

126 study the direct interaction of Ca(2+) with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), the m

127 demonstrated to be secreted from cells in a phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2)-depend

128 nexin A2 (AnxA2), to induce the formation of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2)-rich d

129 d by the presence of its biological product, phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2).

130 Moreover, steady-state PM phosphatidylinositol 4,5-bisphosphate (PI[4,5]P2) levels

131 occur through interactions of proteins with phosphatidylinositol(4,5)-bisphosphate (PI(4,5)P2), whic

132 Regulated by phosphatidylinositol-(4,5)-bisphosphate (PI(4,5)P2)-leve

133 Phospholipase C (PLC)s degrade phosphatidylinositol-4, 5-bisphosphate (PI(4,5)P2) lipid

134 virtue of its affinity to the phospholipid, phosphatidylinositol-4,5-bisphosphate (PI(4,5)P(2)).

135 embrane protein ATP1A1, the phosphoinositide phosphatidylinositol-4,5-bisphosphate (PI(4,5)P2), and T

136 by bradykinin led to a moderate decrease in phosphatidylinositol-4,5-bisphosphate (PI(4,5)P2), but n

137 Phosphatidylinositol-4,5-bisphosphate (PI-4,5-P(2) ) is

138 e proteins are critical for the synthesis of phosphatidylinositol (4,5)-bisphosphate [PI(4,5)P(2)], a

139 on the ability of PI5P4Kalpha to synthesize phosphatidylinositol (4,5)-bisphosphate [PI(4,5)P2] rath

140 M8 requires the plasma membrane phospholipid phosphatidylinositol 4,5-bisphosphate [PI(4,5)P(2) or PI

141 ) enzyme and to lead to a robust decrease in phosphatidylinositol 4,5-bisphosphate [PI(4,5)P(2)] leve

142 for both cooling agonists and membrane lipid phosphatidylinositol 4,5-bisphosphate [PI(4,5)P(2)].

143 evation of cytosolic Ca(2+) and modulated by phosphatidylinositol 4,5-bisphosphate [PI(4,5)P(2)].

144 pase C pathway, leading to the hydrolysis of phosphatidylinositol 4,5-bisphosphate [PI(4,5)P(2)].

145 holipase requiring the cellular host factors phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] and ub

146 Protein kinase C (PKC) and phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] are ob

147 Phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] is a m

148 Phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] is an

149 In this study, we demonstrate that phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] is ano

150 In other systems, phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] is kno

151 In neurons, loss of plasma membrane phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] leads

152 ipid-binding module in TMEM24 transports the phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] precur

153 Plasma membrane (PM) phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] regula

154 idylinositol 3-phosphate [PI(3)P] along with phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] to sti

155 ubule cell survival through interaction with phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2], but p

156 Membrane phosphoinositides, especially phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2], regul

157 itol 4-phosphate 5-kinase that Mcp5 binds to phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2].

158 t-SNARE-carrying vesicles in the absence of phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2].

159 hoinositides, key signaling lipids including phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2].

160 Phosphatidylinositol-(4,5)-bisphosphate [PI(4,5)P(2)] pl

161 erminal myristoylated matrix (MA) domain and phosphatidylinositol-(4,5)-bisphosphate [PI(4,5)P(2)].

162 ion is stimulated by physiological levels of phosphatidylinositol-(4,5)-bisphosphate [PI(4,5)P2] and

163 highly basic region (MA-HBR) interacts with phosphatidylinositol-(4,5)-bisphosphate [PI(4,5)P2], a P

164 to PM sites is facilitated by its binding to phosphatidylinositol-(4,5)-bisphosphate [PI(4,5)P2], and

165 sma membrane (PM)-specific phosphoinositide, phosphatidylinositol-(4,5)-bisphosphate [PI(4,5)P2].

166 binding to the plasma membrane phospholipid phosphatidylinositol-(4,5)-bisphosphate [PI(4,5)P2].

167 Phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2] is ess

168 gion, and a PM-specific acidic phospholipid, phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2].

169 d is dependent on the plasma membrane marker phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2].

170 the plasma membrane via specific binding to phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2].

171 tep activation mechanism of FAK initiated by phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2].

172 In addition, we observed phosphatidylinositol-4,5-bisphosphate (PI4,5P(2)) accumu

173 le interactions with plasma membrane lipids: Phosphatidylinositol (4, 5)-bisphosphate (PIP(2)) activa

174 have previously shown that the phospholipid, phosphatidylinositol (4, 5)-bisphosphate (PIP(2)), direc

175 We also identify a unique phosphatidylinositol (4,5)-bisphosphate (PIP(2)) interac

176 Phosphatidylinositol (4,5)-bisphosphate (PIP(2)) is a ph

177 Here we show that phosphatidylinositol (4,5)-bisphosphate (PIP(2)) regulat

178 Phosphatidylinositol 4,5 bisphosphate (PIP(2)) is a key

179 i/o) activation of TRPC4 through hydrolysing phosphatidylinositol 4,5-bisphosphate (PIP(2) ) to produ

180 ally dependent on and bimodally regulated by phosphatidylinositol 4,5-bisphosphate (PIP(2) ), the sub

181 on of TRPC1 essential for channel opening by phosphatidylinositol 4,5-bisphosphate (PIP(2) ).

182 TRPC1 proteins to promote channel opening by phosphatidylinositol 4,5-bisphosphate (PIP(2) ).

183 ted mechanisms, namely depletion of membrane phosphatidylinositol 4,5-bisphosphate (PIP(2)) and a ris

184 is mediated by its role in the generation of phosphatidylinositol 4,5-bisphosphate (PIP(2)) and in in

185 oform SGK1.1 interacts with phosphoinositide-phosphatidylinositol 4,5-bisphosphate (PIP(2)) and is di

186 In contrast, swapping carboxy-terminal phosphatidylinositol 4,5-bisphosphate (PIP(2)) binding d

187 Phosphatidylinositol 4,5-bisphosphate (PIP(2)) has a sig

188 ransition of this region that is promoted by phosphatidylinositol 4,5-bisphosphate (PIP(2)) is also p

189 h mutant forms of Merlin that cannot bind to phosphatidylinositol 4,5-bisphosphate (PIP(2)) or that c

190 The plasma membrane phospholipid phosphatidylinositol 4,5-bisphosphate (PIP(2)) regulates

191 nsporter (hSERT), in which direct binding of phosphatidylinositol 4,5-bisphosphate (PIP(2)) stabilize

192 Phospholipase C (PLC) converts phosphatidylinositol 4,5-bisphosphate (PIP(2)) to inosit

193 n of G(q/11)-coupled receptors both consumes phosphatidylinositol 4,5-bisphosphate (PIP(2)) via phosp

194 s disrupt current potentiation by increasing phosphatidylinositol 4,5-bisphosphate (PIP(2)), and our

195 dynamically regulated plasma membrane lipid phosphatidylinositol 4,5-bisphosphate (PIP(2)), but it i

196 steric actions of agonist and membrane lipid phosphatidylinositol 4,5-bisphosphate (PIP(2)), but lack

197 The phosphoinositide, phosphatidylinositol 4,5-bisphosphate (PIP(2)), has long

198 persistence in bulk membranes, in particular phosphatidylinositol 4,5-bisphosphate (PIP(2)), initiall

199 ucleotide exchange activity is stimulated by phosphatidylinositol 4,5-bisphosphate (PIP(2)).

200 RF GAP domains of ASAP1, and is modulated by phosphatidylinositol 4,5-bisphosphate (PIP(2)).

201 undown is common among channels regulated by phosphatidylinositol 4,5-bisphosphate (PIP(2)).

202 l C2 domains (C2A and C2B) with affinity for phosphatidylinositol-(4,5)-bisphosphate (PIP(2)).

203 utyrate (PDBu), a PKC catalytic subunit, and phosphatidylinositol-4,5-bisphosphate (PIP(2)) and phosp

204 ds in DRG neurons and injection of exogenous phosphatidylinositol-4,5-bisphosphate (PIP(2)) fully rev

205 he Syt-7 C2AB tandem binds liposomes lacking phosphatidylinositol-4,5-bisphosphate (PIP(2)) with grea

206 e capsaicin receptor, TRPV1, is regulated by phosphatidylinositol-4,5-bisphosphate (PIP(2)), although

207 mechanism involving diacylglycerol (DAG) or phosphatidylinositol-4,5-bisphosphate (PIP(2)).

208 th its interaction with the second messenger phosphatidylinositol (4,5)-bisphosphate (PIP2).

209 Pases Rac1 and Cdc42 as well as by the lipid phosphatidylinositol (4,5)-bisphosphate (PIP2).

210 We previously reported that the phospholipid phosphatidylinositol 4,5-bisphosphate (PIP2 ) directly s

211 Previous work demonstrated that the lipid phosphatidylinositol 4,5-bisphosphate (PIP2 ) enabled th

212 Phosphatidylinositol 4,5-bisphosphate (PIP2) affects the

213 is conformational transition is dependent on phosphatidylinositol 4,5-bisphosphate (PIP2) and is rela

214 a process that involves binding of ezrin to phosphatidylinositol 4,5-bisphosphate (PIP2) and phospho

215 arance and recovery correlated with synaptic phosphatidylinositol 4,5-bisphosphate (PIP2) and that al

216 lly investigated the close interplay between Phosphatidylinositol 4,5-bisphosphate (PIP2) and the F-a

217 Here, we identify phosphatidylinositol 4,5-bisphosphate (PIP2) as a critic

218 analyses of Rabphilin-3A C2B-SNAP25 and C2B-phosphatidylinositol 4,5-bisphosphate (PIP2) complexes,

219 evident at the level of Galphaq activation, phosphatidylinositol 4,5-bisphosphate (PIP2) depletion,

220 s TRPC4/5 channel activity is potentiated by phosphatidylinositol 4,5-bisphosphate (PIP2) depletion.

221 ve previously reported that the phospholipid phosphatidylinositol 4,5-bisphosphate (PIP2) directly st

222 The lipid phosphatidylinositol 4,5-bisphosphate (PIP2) forms nanos

223 from the cell-surface, and redistribution of phosphatidylinositol 4,5-bisphosphate (PIP2) from the pl

224 ducing (pronociceptive) receptors signal via phosphatidylinositol 4,5-bisphosphate (PIP2) hydrolysis.

225 Here, we show that the membrane lipid phosphatidylinositol 4,5-bisphosphate (PIP2) is a potent

226 Phosphatidylinositol 4,5-bisphosphate (PIP2) is critical

227 Plasma membrane phosphatidylinositol 4,5-bisphosphate (PIP2) is required

228 used an initial increase and a later fall in phosphatidylinositol 4,5-bisphosphate (PIP2) levels in t

229 hoinositides in vitro and colocalized with a phosphatidylinositol 4,5-bisphosphate (PIP2) marker in p

230 d it remains unclear how PLCzeta targets its phosphatidylinositol 4,5-bisphosphate (PIP2) membrane su

231 6R associated weakly but preferentially with phosphatidylinositol 4,5-bisphosphate (PIP2) through the

232 -beta) isozymes hydrolyze the membrane lipid phosphatidylinositol 4,5-bisphosphate (PIP2) to propagat

233 lserine, phosphatidic acid, cardiolipin, and phosphatidylinositol 4,5-bisphosphate (PIP2)) PLs contai

234 Cgamma, enzymes that deplete plasma membrane phosphatidylinositol 4,5-bisphosphate (PIP2), and these

235 on by SMIT-transported, myo-inositol-derived phosphatidylinositol 4,5-bisphosphate (PIP2), the mechan

236 diacylglycerols produced by PLC breakdown of phosphatidylinositol 4,5-bisphosphate (PIP2), the mechan

237 e replenishment of the membrane phospholipid phosphatidylinositol 4,5-bisphosphate (PIP2), the source

238 permissive role in myogenesis and depends on phosphatidylinositol 4,5-bisphosphate (PIP2), underlies

239 the N termini in the presence and absence of phosphatidylinositol 4,5-bisphosphate (PIP2), we found t

240 , we show that CDO is contingent on membrane phosphatidylinositol 4,5-bisphosphate (PIP2), which is f

241 2/3 channel activity is augmented in vivo by phosphatidylinositol 4,5-bisphosphate (PIP2), which is g

242 ctivation of IPF fibroblasts, we noticed the phosphatidylinositol 4,5-bisphosphate (PIP2)-binding pro

243 Oxo-M inhibition is occluded by screening phosphatidylinositol 4,5-bisphosphate (PIP2)-negative ch

244 Phosphatidylinositol 4,5-bisphosphate (PIP2)-sensitive t

245 with CCh resulted in a similar reduction in phosphatidylinositol 4,5-bisphosphate (PIP2).

246 cific interactions with the regulatory lipid phosphatidylinositol 4,5-bisphosphate (PIP2).

247 binding to the plasma membrane phospholipid phosphatidylinositol 4,5-bisphosphate (PIP2).

248 known regulator of Kv7 channels is the lipid phosphatidylinositol 4,5-bisphosphate (PIP2).

249 the plasma membrane, it can be inhibited by phosphatidylinositol 4,5-bisphosphate (PIP2).

250 oupling in Kv7.1 channels requires the lipid phosphatidylinositol 4,5-bisphosphate (PIP2).

251 and NBCn1-A by IRBIT and their regulation by phosphatidylinositol 4,5-bisphosphate (PIP2).

252 only in an 84-residue sequence that binds to phosphatidylinositol(4,5)bisphosphate (PIP2), the substr

253 o re-synthesize phosphoinositides, including phosphatidylinositol-(4,5)-bisphosphate (PIP2), resultin

254 ted by conformational changes in response to phosphatidylinositol-4,5-bisphosphate (PIP2) and cargo b

255 al understanding of how the signalling lipid phosphatidylinositol-4,5-bisphosphate (PIP2) and intrace

256 inositides, we investigated the influence of phosphatidylinositol-4,5-bisphosphate (PIP2) availabilit

257 f this linkage is the activation of ezrin by phosphatidylinositol-4,5-bisphosphate (PIP2) binding and

258 Phosphatidylinositol-4,5-bisphosphate (PIP2) is an impor

259 We found that phosphatidylinositol-4,5-bisphosphate (PIP2) or clotrima

260 Nerve functions require phosphatidylinositol-4,5-bisphosphate (PIP2) that binds

261 kinases phosphorylate the constitutive lipid phosphatidylinositol-4,5-bisphosphate (PIP2) to produce

262 the GIRK1 subunit in a manner that requires phosphatidylinositol-4,5-bisphosphate (PIP2), but is oth

263 1 C terminus (CT) binds calmodulin (CaM) and phosphatidylinositol-4,5-bisphosphate (PIP2), but the ro

264 Phosphatidylinositol-4,5-bisphosphate (PIP2), one of the

265 rich C kinase substrate (MARCKS) and release phosphatidylinositol-4,5-bisphosphate (PIP2), thereby st

266 catalyze the final step in the synthesis of phosphatidylinositol-4,5-bisphosphate (PIP2), which in t

267 channels exhibit spontaneous activity via a phosphatidylinositol-4,5-bisphosphate (PIP2)-dependent g

268 ntial for the maintenance of plasma membrane phosphatidylinositol 4,5-bisphosphate pools but only dur

269 ellular phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate pools.

270 6 (LRP5/6) and frizzled proteins, leading to phosphatidylinositol (4,5)bisphosphate (PtdIns(4,5)P(2))

271 hosphatidylinositol 3,4,5-trisphosphate into phosphatidylinositol 4,5-bisphosphate (PtdIns(3,4)P2).

272 sphatidylinositol-5-phosphate (PtsIns5P) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P(2)).

273 pha (also known as PIP5K1A)) and its product phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P(2)).

274 ,5-trisphosphate (Ins(1,4,5)P3) 3-kinase and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) 3-

275 Phosphatidylserine (PtdSer) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) ha

276 eins controlling the lateral organization of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) la

277 inase i5 (PIPKIgammai5), an enzyme producing phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), s

278 n via its actin-binding motor domain and its phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2)-bi

279 phosphorylation via a novel interaction with phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2)-bi

280 TRPM4 is a calcium-activated, phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2) -m

281 he affinity of the polybasic lysine patch to phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2).

282 sphatidylinositol 4-phosphate (PtdIns4P) and phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2] as

283 main enriched in the regulatory phospholipid phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2] is

284 phoinositide second messengers, PtdIns5P and phosphatidylinositol-(4,5)-bisphosphate [PtdIns(4,5)P2].

285 The functions of the minor phospholipid phosphatidylinositol-4,5-bisphosphate [PtdIns(4,5)P2] du

286 Phosphatidylinositol-4,5-bisphosphate (PtdIns4,5P(2)) is

287 domains that exhibit specificity for binding phosphatidylinositol-4,5-bisphosphate (PtdIns4,5P2).

288 ed in all LPS responses, but a single lipid (phosphatidylinositol-4,5-bisphosphate) regulates many LP

289 for promoting the spatially highly organized phosphatidylinositol-4,5-bisphosphate signaling program

290 e 1alpha (PIP5K), the enzyme responsible for phosphatidylinositol 4,5-bisphosphate synthesis, is modi

291 nase that mediates the rate-limiting step in phosphatidylinositol 4,5-bisphosphate synthesis.

292 ning cholesterol, phosphatidylserine, and/or phosphatidylinositol-4,5-bisphosphate, thus providing a

293 embrane and electrostatically interacts with phosphatidylinositol 4,5-bisphosphate to stabilize MA or

294 olipase C-beta (PLC-beta) isoforms hydrolyze phosphatidylinositol 4,5-bisphosphate to the second mess

295 In the presence of 2.5 mum phosphatidylinositol 4,5-bisphosphate, TRPV1 channels de

296 haq Therefore, XY-69 can replace radioactive phosphatidylinositol 4,5-bisphosphate used in convention

297 dynamins bind the plasma membrane-localized phosphatidylinositol-4,5-bisphosphate using the pleckstr

298 ain probe revealed that the regulatory lipid phosphatidylinositol 4,5-bisphosphate was enriched at si

299 arly in IS formation, in parallel to a local phosphatidylinositol (4,5)-bisphosphate wave, and requir

300 bicans IRS4 encodes a protein that regulates phosphatidylinositol-(4,5)-bisphosphate, which was shown