ライフサイエンスコーパス: phosphatidylinositol 4-kinase

1 with the N terminus of Pik1, a 1066-residue phosphatidylinositol 4-kinase.

2 the clone contains the STT4 gene, encoding a phosphatidylinositol 4-kinase.

3 drophobic residues that specifically contact phosphatidylinositol 4-kinase.

4 from fission yeast (Ncs1), which activates a phosphatidylinositol 4-kinase.

5 he transcription factor MYB99 and a putative phosphatidylinositol 4-kinase.

6 ed the Las17-binding protein Lsb6, a type II phosphatidylinositol 4-kinase.

7 y serve as regulators of certain isoforms of phosphatidylinositol 4-kinase.

8 which is associated with the recruitment of phosphatidylinositol 4-kinase 2A.

9 iculum (ER)-lysosome membrane contact sites, phosphatidylinositol 4-kinase-2a (PI4K2A), phosphatidyli

10 st, blockade of lipid kinases, in particular phosphatidylinositol-4-kinase, abolished recovery, as di

11 PITP did not enhance the initial rate of phosphatidylinositol 4-kinase activity but did increase

12 xpression of PI4KIIalpha increased the basal phosphatidylinositol 4-kinase activity of each membrane

13 pstB1 mutant exhibits a defect in Stt4p-type phosphatidylinositol 4-kinase activity, and direct gene

14 overexpression of frequenin, a modulator of phosphatidylinositol 4-kinase activity, on biosynthetic

15 tments, a corresponding increase in cellular phosphatidylinositol 4-kinase activity.

16 the vacuolar surface, and associated with a phosphatidylinositol-4 kinase activity.

17 mechanism that tethers Arabidopsis thaliana phosphatidylinositol 4-kinase alpha1 (PI4Kalpha1) to the

18 of a plant phosphatidylinositol 3-kinase and phosphatidylinositol 4-kinase, an observation that sugge

19 ow that PKCmu forms a complex in vivo with a phosphatidylinositol 4-kinase and a phosphatidylinositol

20 tial action of a lysosome-associated type II phosphatidylinositol 4-kinase and a soluble type I phosp

21 pervillin, MAGuK, three heat shock proteins, phosphatidylinositol 4-kinase and receptor protein tyros

22 By pharmacologically blocking phosphatidylinositol-4-kinase and PIPKI or disrupting th

23 sphatidylinositol 3-kinase), PI4Ka-like Stt4 phosphatidylinositol 4-kinase, and Psd2 phosphatidylseri

24 Phosphatidylinositol 4-kinases are most abundant in the

25 7A interacts with EFR3 homolog B to regulate phosphatidylinositol 4-kinase at the plasma membrane.

26 RL5B were found to interact with and recruit phosphatidylinositol 4-kinase beta (PI4KB) at trans-Golg

27 Phosphatidylinositol 4-kinase beta (PI4KB) is one of fou

28 through SC-specific genetic inactivation of phosphatidylinositol 4-kinase beta (PI4KB), a Golgi-asso

29 y showed a similar distribution of NCS-1 and phosphatidylinositol 4-kinase beta (PI4Kbeta).

30 man oligosaccharyltransferase complex, and a phosphatidylinositol 4-kinase beta adaptor hijacked by v

31 ndant phosphoinositide biosynthesis enzymes, phosphatidylinositol 4-kinase beta proteins (PI4Kbetas),

32 ent inhibitors of Plasmodium falciparum (Pf) phosphatidylinositol-4-kinase beta (PI4K), identified 1,

33 s include GROWTH REGULATORY FACTOR 1 (GRF1), PHOSPHATIDYLINOSITOL 4-KINASE beta1 (PI-4Kbeta1), and OB

34 Supporting this idea, inhibition of phosphatidylinositol 4-kinase, but not the RhoA effector

35 iazolopyridine core disturbed the binding to phosphatidylinositol 4-kinase, catalytic beta (PIK4CB).

36 The activity of phosphatidylinositol 4-kinase class III beta (PI4KIIIbet

37 s by concentrations of wortmannin that block phosphatidylinositol 4-kinase completely blocked calcium

38 Thus, Nir2, along with VAPs, OSBP, and the phosphatidylinositol 4-kinase, completes a cycle of phos

39 c1 homology domain, in complex with Vps74, a phosphatidylinositol 4-kinase effector and the orthologu

40 e unique inhibitor sensitivities of type-III phosphatidylinositol 4-kinase enzymes (PI4Ks).

41 onserved role for Gga proteins in regulating phosphatidylinositol 4-kinase function at the TGN.

42 The Stt4 phosphatidylinositol 4-kinase has been shown to generate

43 ammalian cells express two type II isoforms, phosphatidylinositol 4-kinase IIalpha (PI4KIIalpha) and

44 Phosphatidylinositol 4-kinase IIalpha (PI4KIIalpha) is p

45 rectly correlated with increased activity of phosphatidylinositol 4-kinase IIalpha (PI4KIIalpha), a l

46 Phosphatidylinositol 4-kinase IIalpha (PI4KIIalpha), a m

47 oinositide kinase activity is contributed by phosphatidylinositol 4-kinase IIalpha (PI4KIIalpha).

48 We show herein that phosphatidylinositol-4-kinase IIalpha (PI4KIIalpha) play

49 The lipid kinase phosphatidylinositol 4 kinase III alpha (PI4KIIIalpha/PI

50 Phosphatidylinositol 4-kinase III alpha (PI4KA) is an es

51 High expression of phosphatidylinositol 4-kinase III alpha (PI4KIIIalpha) c

52 cluding oxysterol binding protein (OSBP) and phosphatidylinositol 4-kinase III beta (PI4KB).

53 Here we show that the lipid kinase phosphatidylinositol 4-kinase III beta (PI4KIIIbeta) reg

54 eviously shown to interact with and modulate phosphatidylinositol 4-kinase III-beta (PI4KIIIbeta) act

55 ation was dependent on mouse cyclophilin and phosphatidylinositol-4 kinase III alpha (PI4KIIIalpha) a

56 Phosphatidylinositol 4-kinase IIIa (PI4KIIIa/PI4KA/OMIM:

57 Phosphatidylinositol 4 kinase IIIalpha (PI4KIIIalpha/PI4

58 tes the activity of a cellular lipid kinase, phosphatidylinositol 4-kinase IIIalpha (PI4KA).

59 ysis identified the evolutionarily conserved phosphatidylinositol 4-kinase IIIalpha (PI4KIIIalpha), a

60 plicated independently from microRNA-122 and phosphatidylinositol 4-kinase IIIalpha and beta (PI4KIII

61 d RhoA signaling and defective expression of phosphatidylinositol 4-kinase IIIalpha represent biochem

62 g the synthesis of PIP(2) via stimulation of phosphatidylinositol 4-kinase IIIalpha.

63 ties of NS5A, including its interaction with phosphatidylinositol-4 kinase IIIalpha and induction of

64 eb, which was not linked to an inhibition of phosphatidylinositol-4 kinase IIIalpha.

65 ized to the Golgi complex, and both regulate phosphatidylinositol 4-kinase IIIbeta (PI(4)Kbeta).

66 This class inhibits phosphatidylinositol 4-kinase IIIbeta (PI4K) in the huma

67 n revealed that Pipinib selectively inhibits phosphatidylinositol 4-kinase IIIbeta (PI4KB) and suppre

68 teroviruses, enterovirus 71 (EV71) relies on phosphatidylinositol 4-kinase IIIbeta (PI4KB) for genome

69 The lipid kinase phosphatidylinositol 4-kinase IIIbeta (PI4KB) is an esse

70 Phosphatidylinositol 4-kinase IIIbeta (PI4KB) is indispe

71 Instead, ARMH3 functions to activate phosphatidylinositol 4-kinase IIIbeta (PI4KB), accountin

72 to enviroxime-like compounds, which target a phosphatidylinositol 4-kinase IIIbeta (PI4KIIIbeta)-depe

73 Previously reported antimalarial Plasmodium phosphatidylinositol 4-kinase IIIbeta 2,8-diaryl-1,5-nap

74 ibosylation factor 1 (Arf1) or its effector, phosphatidylinositol 4-kinase IIIbeta [PI(4)KIIIbeta], i

75 iated by an up-regulated interaction between phosphatidylinositol 4-kinase IIIbeta and PKC; the incre

76 Phosphatidylinositol 4-kinase IIIbeta is a cellular lipi

77 rotein of enterovirus 71 recruits an enzyme, phosphatidylinositol 4-kinase IIIbeta, by interacting wi

78 found to be through an enhanced activity of phosphatidylinositol 4-kinase IIIbeta, which was mediate

79 GBF1, promoting preferential recruitment of phosphatidylinositol-4-kinase IIIbeta (PI4KIIIbeta) to m

80 Enzymatic and immunochemical assays show a phosphatidylinositol 4-kinase in novel and specific comp

81 MMV390048 is the first Plasmodium phosphatidylinositol 4-kinase inhibitor to reach clinica

82 venger polylysine, and the inhibition by the phosphatidylinositol 4-kinase inhibitor wortmannin corre

83 However, because phosphatidylinositol 4-kinase is an integral chromaffin

84 st, the sole essential target of Frq1 is the phosphatidylinositol 4-kinase isoform, Pik1; both FRQ1 a

85 he EF-hand superfamily and regulates a yeast phosphatidylinositol 4-kinase isoform.

86 Mammalian type II phosphatidylinositol 4-kinases may regulate WASp protein

87 Depletion of PIP(2) by inhibition of phosphatidylinositol 4-kinase or sequestration by aminog

88 Inhibition of phosphatidylinositol 4-kinases or enzymatic removal of p

89 he size (55 kDa) and other properties of the phosphatidylinositol 4-kinase (PI 4-K) (stimulated by no

90 n contrast, expression of the NCS-1 effector phosphatidylinositol 4-kinase (PI 4-kinase) inhibited in

91 fwd is shown to encode a phosphatidylinositol 4-kinase (PI 4-kinase), a member of

92 sent genetic and biochemical evidence that a phosphatidylinositol 4-kinase (PI 4-kinase), STT4, is a

93 Phosphatidylinositol 4-kinases (PI 4-kinases) catalyze t

94 ulation, RabA4B recruits the closely related phosphatidylinositol 4-kinase (PI4K) PI4Kbeta1 and PI4Kb

95 Mammalian cells express two classes of phosphatidylinositol 4-kinase (PI4K), designated as Type

96 vated TRPM8 channels in excised patches in a phosphatidylinositol 4-kinase (PI4K)-dependent manner.

97 Because phosphatidylinositol 4-kinase (PI4K)-mediated phosphatid

98 Phosphatidylinositol 4-kinases (PI4K) catalyze the first

99 centration (3 mum), suggesting that type III phosphatidylinositol-4-kinase (PI4K) activity is require

100 vestigated via inhibition of the activity of phosphatidylinositol-4-kinase (PI4K).

101 embrane-associated interactors including the phosphatidylinositol 4-kinase (PI4KA) complex containing

102 phosphatidylinositol 3-kinase (PI3K), and 3) phosphatidylinositol 4-kinase (PI4Ka-like).

103 red for HCV replication, including class III phosphatidylinositol 4-kinases (PI4KA and PI4KB), carbam

104 CD63-mediated SG maturation requires type II phosphatidylinositol 4 kinase (PI4KII)-dependent early e

105 The type II phosphatidylinositol 4-kinase (PI4KII) enzymes synthesiz

106 malian cells express two isoforms of type II phosphatidylinositol 4-kinase: PI4KIIalpha and PI4KIIbet

107 olated mutations in CG10260, which encodes a phosphatidylinositol 4-kinase (PI4KIIIalpha), and found

108 Type III phosphatidylinositol 4-kinase (PI4KIIIbeta) is an essent

109 osphate (PI4P) biosynthesis regulated by the phosphatidylinositol 4-kinases PI4KIIIbeta1 and PI4KIIIb

110 Unlike PI3Ks, phosphatidylinositol 4-kinases (PI4Ks) and phosphatidyli

111 Phosphatidylinositol 4-kinases (PI4Ks) and small guanosi

112 Two phosphatidylinositol 4-kinases (PI4Ks) have been localiz

113 We found that distinct phosphatidylinositol 4-kinases (PI4Ks) play important ro

114 he biogenesis of cargo transport vesicles by phosphatidylinositol 4-kinases (PI4Ks) that produce phos

115 ly different compounds that inhibit type III phosphatidylinositol 4-kinases (PI4Ks).

116 ecreased by inhibition or down-regulation of phosphatidylinositol 4-kinases (PI4Ks).

117 l N-myristoylated EF-hand protein, activates phosphatidylinositol 4-kinase Pik1.

118 Phosphatidylinositol 4-kinase, Pik1, is essential for vi

119 We identify two motifs in the yeast phosphatidylinositol 4-kinase, Pik1, which are required

120 D8 ubiquitin-like protein (rub1Delta), and a phosphatidylinositol 4-kinase (pik1Delta).

121 In Saccharomyces cerevisiae, the phosphatidylinositol 4-kinase, Pik1p generates a distinc

122 Phosphatidylinositol 4-kinases play essential roles in c

123 e conclude that frequenin, and by inference, phosphatidylinositol 4-kinase, plays an important and se

124 and complexes of CD63 (a TM4SF protein) with phosphatidylinositol 4-kinase (PtdIns 4-K) may indeed lo

125 Phosphatidylinositol 4-kinases (PtdIns 4-kinases or PI4K

126 ed a considerably higher level of associated phosphatidylinositol-4-kinase (PtdIns 4-kinase) activity

127 hich encodes a conserved PM scaffold for the phosphatidylinositol-4 kinase Stt4, build CRs that can s

128 Here we show that Pik1, a phosphatidylinositol 4-kinase that localizes primarily t

129 We now describe a novel class of phosphatidylinositol 4-kinases that probably corresponds

130 ence (RNAi) of PI4KIIalpha, a Golgi resident phosphatidylinositol 4 kinase, to determine whether PI(4

131 Defects in the phosphatidylinositol 4-kinase-TTC7A-EFR3 homolog B pathw

132 In particular, the role of the TTC7A/phosphatidylinositol 4 kinase type III alpha pathway in

133 s the trafficking of late endosomes carrying phosphatidylinositol 4-kinase type 2 alpha (PI4KIIalpha)

134 We investigated the relationship between Phosphatidylinositol 4-Kinase Type 2 Beta (PI4K2B) expre

135 small interfering RNA library, we identified phosphatidylinositol 4-kinase type II alpha and phosphat

136 ed sequentially by Myotubularin 1 (MTM1) and phosphatidylinositol 4-kinase type IIalpha (PI4KIIalpha)

137 revealed that AZD0156 inhibits P. falciparum phosphatidylinositol 4-kinase type III beta (PfPI4Kbeta)

138 targets, and potent inhibition of Plasmodium phosphatidylinositol 4-kinase type III beta (PI4Kbeta) a

139 um kinases, including the high-value targets phosphatidylinositol 4-kinase type III beta (PI4Kbeta) a

140 Phosphatidylinositol 4-kinase type IIIalpha (PI4KA) is a

141 Upon LMP, phosphatidylinositol-4 kinase type 2alpha (PI4K2A) accum

142 his hypothesis by analyzing the targeting of phosphatidylinositol-4-kinase type II alpha (PI4KIIalpha

143 Phosphatidylinositol-4-kinase type II alpha (PI4KIIalpha

144 tein sorting complex subunits; clathrin; and phosphatidylinositol-4-kinase type II alpha (PI4KIIalpha

145 eficiencies affected the targeting of LAMP1, phosphatidylinositol-4-kinase type II alpha, and VAMP7-T

146 t with and are regulated by the lipid kinase phosphatidylinositol-4-kinase type IIalpha (PI4KIIalpha)

147 A protein enriched in this fraction was phosphatidylinositol-4-kinase type IIalpha (PI4KIIalpha)

148 Phosphatidylinositol 4-kinase was found to co-immunoprec

149 f the alpha(3)beta(1)-CD151Cys8 complex with phosphatidylinositol 4-kinase was not affected.

150 trongest temporal change is seen at a SNP in phosphatidylinositol 4-kinase, which is involved in a pa

151 The novel phosphatidylinositol 4-kinases, which are widely express

152 Inhibiting phosphatidylinositol 4 kinases with wortmannin decreased