ライフサイエンスコーパス: phosphatidylserine

1 he binding is facilitated by the presence of phosphatidylserine.

2 associate with anionic phospholipids such as phosphatidylserine.

3 stimuli, including the anionic phospholipid phosphatidylserine.

4 grin tension is coupled with the exposure of phosphatidylserine.

5 asts, with a strong substrate preference for phosphatidylserine.

6 ed mutant of C2Am (iC2Am) that does not bind phosphatidylserine.

7 ace of these two processes resides the lipid phosphatidylserine.

8 hospholipid mixtures with a high fraction of phosphatidylserine.

9 ipid exchange method was then used to remove phosphatidylserine, a phagocyte recognition marker, from

10 0A) maintains the asymmetric distribution of phosphatidylserine, an integral component of the cell me

11 corporation of anionic phospholipids such as phosphatidylserine and an acidic pH.

12 Total PL and PC, PE, phosphatidylinositol + phosphatidylserine and CL contained higher levels of ole

13 We find that phosphatidylserine and ergosterol are essential for Lyp1

14 tides antagonize the binding of factor Xa to phosphatidylserine and inhibit the enzymatic activity of

15 the selective binding of the PLAT domain to phosphatidylserine and L-alpha-phosphatidylinositol-4-ph

16 nly observed upon binding onto monolayers of phosphatidylserine and not in the case of other anionic

17 ulin secretory granules (ISG) suggested that phosphatidylserine and other phospholipids, such as phos

18 ell membrane was built with equal amounts of phosphatidylserine and phosphatidylcholine.

19 ereas the inner, cytoplasmic leaf is rich in phosphatidylserine and phosphatidylcholine.

20 ATP8A2 is a P4-ATPase that flips phosphatidylserine and phosphatidylethanolamine across c

21 complex mixture of phospholipids, especially phosphatidylserine and phosphatidylethanolamine, in TBSV

22 We show that the natural ligands of CD300c, phosphatidylserine and phosphatidylethanolamine, modulat

23 ls is mediated by aminophospholipid ligands, phosphatidylserine and phosphatidylethanolamine, which a

24 but less extreme than their GB values, with phosphatidylserine and phosphatidylglycerol being the mo

25 Phosphatidylinositol, phosphatidylserine and phosphatidylglycerol were minor g

26 that this protein plays a role in recruiting phosphatidylserine and phosphatidylinositides to Atg16L-

27 VP40 residues in the absence and presence of phosphatidylserine and phosphatidylinositol 4,5-bisphosp

28 rization induces nanoscale reorganization of phosphatidylserine and phosphatidylinositol 4,5-bisphosp

29 receptor phospho-Tyr and two anionic lipids (phosphatidylserine and PIP2) to make PI3Kalpha competent

30 ion, granularity, mitochondrial content, and phosphatidylserine and protein receptor surface expressi

31 e stimulation, the concentration of many ISG phosphatidylserines and phosphatidylinositols increased;

32 drial membrane potential, externalization of phosphatidylserine, and DNA fragmentation, that ultimate

33 ed MPs expressed VE-cadherin and superficial phosphatidylserine, and in a thrombin generation assay,

34 pholipids in vitro, notably, cardiolipin and phosphatidylserine, and interacts with liposomes contain

35 lysis, allosteric activation, stimulation by phosphatidylserine, and pharmacological inhibition by th

36 osphatidylethanolamine, phosphatidylcholine, phosphatidylserine, and phosphatidic acid classes.

37 -sn-glycero-3-phosphocholine or cholesterol, phosphatidylserine, and phosphatidylcholine, two low-aff

38 ted in flipping of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine.

39 s were formed with a mixture of cholesterol, phosphatidylserine, and phosphatidylcholine.

40 rations of negatively charged phospholipids, phosphatidylserine, and phosphatidylinositol in ISG were

41 spholipids, which include phosphatidic acid, phosphatidylserine, and phosphoinositides, represent a s

42 osphatidic acids, phosphatidylethanolamines, phosphatidylserines, and phosphoinositides.

43 verse correlation between the levels of anti-phosphatidylserine antibodies and plasma hemoglobin, sug

44 -not-eat-me" signal, but the binding of anti-phosphatidylserine antibodies mediates their phagocytosi

45 tion, such as docosahexaenoic acid (DHA) and phosphatidylserines, appear early and then fall dramatic

46 Phosphatidylethanolamine and phosphatidylserine are found to be similar in GB to basi

47 hemical and biophysical methods, we identify phosphatidylserine as a molecular target of Apo-15.

48 njugates through the zinc(II) dipicolylamine-phosphatidylserine association and resulted in compoundi

49 C-STAMP)-dependent non-apoptotic exposure of phosphatidylserine at the surface of fusion-committed ce

50 ic G12V-KRAS mutant in a phosphatidylcholine/phosphatidylserine bilayer, we first show that internal

51 Using a phosphatidylserine binding domain and an RGD motif, MFG-

52 aenorhabditis elegans PSR, mediates specific phosphatidylserine binding in vitro and clearance of apo

53 We describe here the validation of a phosphatidylserine-binding agent for detecting tumor cel

54 Here, we report utility of the phosphatidylserine-binding conjugate of Bis(zinc(II)-dip

55 function normally provided by the C-terminal phosphatidylserine-binding KA1 domain (residues 1379-151

56 the fluorophores conjugated to annexin V, a phosphatidylserine-binding probe commonly used to report

57 ish and identified Cavin-2, a membrane-bound phosphatidylserine-binding protein and critical organize

58 ssays, this study demonstrates that PR3 is a phosphatidylserine-binding protein and this interaction

59 ion also depended on extracellular annexins, phosphatidylserine-binding proteins, which, along with a

60 that can be replaced by other, heterologous phosphatidylserine-binding sequences.

61 Finally, saturating the phosphatidylserine-binding sites on HIV target cells did

62 Phosphatidylserine binds to an integral-membrane N-termi

63 so contain background anionic lipids such as phosphatidylserine but much weaker when either the backg

64 Inhibition of phosphatidylserine, but not administration of antisickli

65 for phosphatidylethanolamine synthesis from phosphatidylserine catalyzed by phosphatidylserine decar

66 c phospholipids and sphingolipids, including phosphatidylserine, ceramide-1-phosphate, glucosylcerami

67 Inhalation of phosphatidylserine coated liposome loaded with STING ago

68 ufficient to drive its weak association with phosphatidylserine-containing membranes, whereas in C2B,

69 h Pb(2+)-complexed C2 domains associate with phosphatidylserine-containing membranes.

70 ein mesh able to form polyhedral lattices on phosphatidylserine-containing vesicles.

71 drial inner membrane (IM) and is executed by phosphatidylserine decarboxylase (Psd1).

72 Phosphatidylserine decarboxylase 1 (Psd1p), an ancient e

73 he mitochondrial enzyme that generates PE is phosphatidylserine decarboxylase 1 (Psd1p).

74 nthesis from phosphatidylserine catalyzed by phosphatidylserine decarboxylase enzymes (PSD) as a suit

75 Here, we demonstrate that the phosphatidylserine decarboxylase Psd1, located in the in

76 ndrial localization of a key pathway enzyme, phosphatidylserine decarboxylase Psd1, which generates p

77 ugh reduction of the levels of mitochondrial phosphatidylserine decarboxylase, which is involved in t

78 Phosphatidylserine decarboxylases (PSDs) are central enz

79 Phosphatidylserine decarboxylases (PSDs) catalyze the co

80 Phosphatidylserine decarboxylases (PSDs) catalyze the de

81 e C-terminal 33 residues resulted in reduced phosphatidylserine-dependent ATPase activity, phosphatid

82 Notably, "soluble" phosphatidylserine (dihexanoyl-phosphatidylserine) faile

83 the engulfment of erythrocytes with exposed phosphatidylserine directly modulated the phenotype of b

84 er and that incorporation of PI(4,5)P(2) and phosphatidylserine enhances the binding of MA to nanodis

85 ine-rich C-kinase substrate (MARCKS) bind to phosphatidylserine exposed on activated platelets and th

86 In particular, phosphatidylserine exposed on the external leaflet of th

87 They show that fibrin interacts with phosphatidylserine exposed on the senescent sickle red c

88 ein S and Gas6 are involved in the uptake of phosphatidylserine-exposing apoptotic cells in macrophag

89 We find that phosphatidylserine-exposing erythrocytes are reticulocyt

90 ) T cells following phagocytosis of injured, phosphatidylserine-exposing oligodendroglial cells is ab

91 ncentrations measured in healthy volunteers, phosphatidylserine-exposing platelet extracellular vesic

92 Next, we discuss the molecular mechanisms of phosphatidylserine exposure during necroptosis and its r

93 markers of GSDMD activation, correlated with phosphatidylserine exposure in peripheral leukocytes and

94 annel that is required for Ca(2+) -activated phosphatidylserine exposure on the surface of many eukar

95 pores mediated calcium influx, which induced phosphatidylserine exposure through transmembrane protei

96 throcyte sickling, and increased erythrocyte phosphatidylserine exposure was also observed.

97 ll death analysis by morphologic assessment, phosphatidylserine exposure, caspase cleavage and chemic

98 ne potential dissipation, membrane blebbing, phosphatidylserine exposure, DNA damage and chromatin co

99 sembled acanthocytes and displayed increased phosphatidylserine exposure, high intracellular calcium,

100 of gasdermin D (GSDMD) pores and subsequent phosphatidylserine exposure, in a manner independent of

101 phage proinflammatory cytokine release after phosphatidylserine exposure.

102 ceptor for C1q, an eat-me signal, that binds phosphatidylserine expressed on the surface of apoptotic

103 h flow cytometry and phenotyped according to phosphatidylserine expression (PS(+)/PS(-)), cellular or

104 via reducing thromboxane B(2) and modulating phosphatidylserine expression) to promote cerebral prote

105 iated with the initiation and propagation of phosphatidylserine externalization after axotomy.SIGNIFI

106 time-lapse imaging to study the dynamics of phosphatidylserine externalization immediately after axo

107 ucing drug, slowed the onset and velocity of phosphatidylserine externalization in wild-type axons si

108 Phosphatidylserine externalization is an early molecular

109 The extension of phosphatidylserine externalization was slowed and delaye

110 embrane phospholipid polarity, manifested as phosphatidylserine externalization, which was significan

111 ly, "soluble" phosphatidylserine (dihexanoyl-phosphatidylserine) failed to stimulate C1P transfer.

112 hosphatidylserine-dependent ATPase activity, phosphatidylserine flippase activity, and neurite extens

113 however, assembled with CDC50A and displayed phosphatidylserine flippase activity.

114 n with its subunit CDC50A, and function as a phosphatidylserine flippase.

115 ) yeast Psd1p does not require its substrate phosphatidylserine for autocatalysis; and 3) contrary to

116 y translocating phosphatidylethanolamine and phosphatidylserine from the outer leaflet to the cytosol

117 nity of recoverin for the negatively charged phosphatidylserine has been clearly shown to be governed

118 We further elucidated mechanistically that phosphatidylserine in EVs was a key triggering-factor, a

119 od coagulation by catalyzing the exposure of phosphatidylserine in platelets.

120 the level of the N-containing lipids PE and phosphatidylserine in root hairs decreased whereas the l

121 led to the discovery of the critical role of phosphatidylserine in TBSV replication and a novel role

122 eutic loop through the in situ generation of phosphatidylserine in the tumor microenvironment.

123 membrane by electrostatic interactions with phosphatidylserine, in turn undergoes enhanced nanoclust

124 sitols increased; unsaturated fatty acids in phosphatidylserine increased; and most phosphatidylethan

125 This motif also mediates phosphatidylserine-induced oligomerization of PSR-1, sug

126 Blocking phosphatidylserine, inhibiting thrombin or blocking PAR1

127 phagocytosis-like process that depends on a phosphatidylserine/integrin complex, driven by actin-ric

128 As phosphatidylserine is a major component of microvesicles

129 eted from this periprotein lipidome, whereas phosphatidylserine is enriched relative to the bulk of t

130 ization of lipids, e.g. a large diversity of phosphatidylserine lipids in brain compared to other org

131 zwitterionic phosphatidylcholine and anionic phosphatidylserine lipids in mixed lipid membranes.

132 effects are more pronounced for the anionic phosphatidylserine lipids than for zwitterionic phosphat

133 Both the phosphatase and C2 domains bind phosphatidylserine lipids, which likely helps to positio

134 epends strongly on interactions with anionic phosphatidylserine lipids.

135 Direct binding of NM2s to phosphatidylserine-liposomes, but not to phosphatidylcho

136 platelet secretion, and surface exposure of phosphatidylserine, loss of the Rap1-talin-1 interaction

137 Triacylglycerides, phosphatidylserines, lysophosphatidylethanolamines, lyso

138 We demonstrate that phosphatidylserine maintains PDK1 in an inactive conform

139 Next, the phosphatidylserine marker GFP::Lact-C2 was expressed in

140 ed and the possibility of ligand-independent phosphatidylserine-mediated binding is explored.

141 amics simulations yielded a dynamic model of phosphatidylserine membrane recognition by Tim1 with ato

142 highest affinity for ZENV; HSP70, TIM-1, and phosphatidylserine might also play active roles in zika

143 SR-A siRNA and catalase complexation, and a phosphatidylserine-modified rHDL-based outer shell for S

144 ic residues of MA and multiple PI(4,5)P2 and phosphatidylserine molecules.

145 ects competes for annexin V on an artificial phosphatidylserine monolayer, replicating a key activity

146 as the extent of penetration of recoverin in phosphatidylserine monolayers was estimated by ellipsome

147 eir ability to recognize the 'eat-me' signal phosphatidylserine on apoptotic cells.

148 necrosis by binding to the phagocytic marker phosphatidylserine on dying tumour cells.

149 Functionally, masking phosphatidylserine on sperm via three different approach

150 otic mimicry, many enveloped viruses display phosphatidylserine on the outer leaflet of their membran

151 r typical scavenger receptors that recognize phosphatidylserine on the surface of dead cells.

152 Moreover, the levels of phosphatidylserine on the surface of HIV-1 particles, wh

153 ramblase activity results in the exposure of phosphatidylserine on the surface of RBCs, decreasing RB

154 Activated platelets expose phosphatidylserine on their outer membrane leaflet and a

155 brane-derived microparticles (PMPs) exposing phosphatidylserine on their surface.

156 Collectively, these data identify phosphatidylserine on viable sperm and PtdSer recognitio

157 er for partitioning into negatively charged (phosphatidylserine or phosphatidylcholine) membranes tha

158 p11, ablation of Gsdmd, or neutralization of phosphatidylserine or TF prevented LPS-induced DIC.

159 hich express immunomodulatory molecules like phosphatidylserine or TGF-beta1.

160 eric state that preferentially binds anionic phosphatidylserine over neutral phosphatidylcholine.

161 ) and phospholipids (FXa/phosphatidylcholine-phosphatidylserine [PCPS]) vs LD100 Escherichia coli We

162 e and phosphatidylethanolamine) and anionic (phosphatidylserine, phosphatidic acid, cardiolipin, and

163 the inner leaf of phosphatidylethanolamine, phosphatidylserine, phosphatidylcholine, and cholesterol

164 he anionic phospholipids, phosphatidic acid, phosphatidylserine, phosphatidylglycerol, and phosphatid

165 containing one or more acidic phospholipids (phosphatidylserine, phosphatidylinositol 4,5-diphosphate

166 ynaptotagmin interaction with anionic lipid (phosphatidylserine/phosphatidylinositol) containing memb

167 r, 71 sulfatides and 59 polar phospholipids (phosphatidylserines, phosphatidylinositols, lysophosphat

168 tidylethanolamine, phosphatidylinositol, and phosphatidylserine profiles.

169 composition-specifically by the presence of phosphatidylserine-providing new clues to pHLIP's unique

170 We measured anti-phosphatidylserine (PS) and anti-DNA antibody levels in

171 We demonstrate that Mfn2 binds phosphatidylserine (PS) and can specifically extract PS

172 Furthermore, Na,K-ATPase activity depends on phosphatidylserine (PS) and cholesterol, which stabilize

173 mediated by endothelial cells (ECs) through phosphatidylserine (PS) and examined the effect of plate

174 We investigated the biologic effect of phosphatidylserine (PS) and phosphatidylcholine (PC), 2

175 these major biological processes.IMPORTANCE Phosphatidylserine (PS) and phosphatidylethanolamine (PE

176 ype (WT) yeast normally restrict most of the phosphatidylserine (PS) and phosphatidylethanolamine (PE

177 n real-time assays, we find that unsaturated phosphatidylserine (PS) and sterols, both Osh protein li

178 FF-1 fusogen after axotomy, and establishing phosphatidylserine (PS) and the PS receptor (PSR-1) as c

179 ir ligands phosphatidylethanolamine (PE) and phosphatidylserine (PS) and their differential ability t

180 erythrocytes is promoted by autoimmune anti-phosphatidylserine (PS) antibodies produced by T-bet(+)B

181 Phosphatidylethanolamine (PE) and phosphatidylserine (PS) are ubiquitously expressed and m

182 s hsc-70 interaction with negatively charged phosphatidylserine (PS) at the endosomal limiting membra

183 sensor proteins (mNG-KRn), and the specific phosphatidylserine (PS) binding protein Evectin2.

184 mbin-stimulated platelets expose very little phosphatidylserine (PS) but express binding sites for fa

185 acidic region, preferentially interacts with phosphatidylserine (PS) compared with other phospholipid

186 ng proteins bind to membrane components in a phosphatidylserine (PS) dependent manner to assemble mul

187 -dependent platelet signaling with defective phosphatidylserine (PS) exposure and microparticle forma

188 but instead associated with reduced platelet phosphatidylserine (PS) exposure and procoagulant functi

189 In this issue of Blood, Mankelow et al link phosphatidylserine (PS) exposure in sickle erythrocytes

190 Phosphatidylserine (PS) exposure is increased in red cel

191 , MLKL-dependent calcium (Ca(2+)) influx and phosphatidylserine (PS) exposure on the outer leaflet of

192 shrinkage and cell membrane scrambling with phosphatidylserine (PS) exposure.

193 ral bioeffects triggered by nsPEF, including phosphatidylserine (PS) externalization, nanopore-conduc

194 , increased lipid-raft disruption, decreased phosphatidylserine (PS) flip from the cell-surface, and

195 The specific function of phosphatidylserine (PS) in the context of the developmen

196 Phosphatidylserine (PS) interacts at the previously iden

197 rs published in The EMBO Journal reveal that phosphatidylserine (PS) is a neuronal cue for microglial

198 Phosphatidylserine (PS) is an abundant charged lipid tha

199 Phosphatidylserine (PS) is asymmetrically distributed be

200 we present evidence that surface exposure of phosphatidylserine (PS) is pivotal for ADAM17 to exert s

201 osphatidylinositol 4,5 bisphosphate, even if phosphatidylserine (PS) is present in the cis membrane.

202 ast species have shown that the phospholipid phosphatidylserine (PS) is synthesized from CDP-diacylgl

203 Herein, we show that Zn(2+) binds to phosphatidylserine (PS) lipids in supported lipid bilaye

204 The interaction between immune cells and phosphatidylserine (PS) molecules exposed on the surface

205 ormation, the exposure of negatively charged phosphatidylserine (PS) on adherent leukocytes, and clot

206 a vacuolar protein B (CvpB) binds PI(3)P and phosphatidylserine (PS) on CCVs and early endosomal comp

207 Phosphatidylserine (PS) on presynaptic elements binds GP

208 The detection of externalized phosphatidylserine (PS) on the cell surface is commonly

209 increase exposure of the negatively charged phosphatidylserine (PS) on the outer leaflet of the plas

210 observed during apoptosis is the exposure of phosphatidylserine (PS) on the outer plasma membrane.

211 OV, and that the interaction between TIM and phosphatidylserine (PS) on the surface of EBOV mediates

212 We discovered that IFNgamma is captured by phosphatidylserine (PS) on the surface of viable cells b

213 Specifically, phosphatidylserine (PS) receptors - including members of

214 Phosphatidylserine (PS) receptors mediate clearance of a

215 ily proteins were recently found to serve as phosphatidylserine (PS) receptors which promote infectio

216 Here, we show that exposed phosphatidylserine (PS) represents a neuronal "eat-me" s

217 Mutations in thePTDSS1gene coding one of the phosphatidylserine (PS) synthase enzymes, PSS1, were des

218 Diabetic MPs show greater externalized phosphatidylserine (PS) than normal MPs.

219 rboxylases (PSDs) catalyze the conversion of phosphatidylserine (PS) to phosphatidylethanolamine (PE)

220 rmation, we observed a significant number of phosphatidylserine (PS)+ platelets in PNAs in CypDplt+/+

221 encoding PTDSS1, an enzyme that synthesizes phosphatidylserine (PS), a phospholipid constituent of t

222 Phosphatidylserine (PS), an 'eat-me' signal for macropha

223 thanolamine (PE), phosphatidylinositol (PI), phosphatidylserine (PS), and phosphatidyl-glycerol (PG)

224 EnDi-modified phosphatidylethanolamine (PE), phosphatidylserine (PS), and phosphatidylcholine (PC) li

225 VSMC exosome composition and accumulation of phosphatidylserine (PS), annexin A6 and matrix metallopr

226 re submicron extracellular vesicles exposing phosphatidylserine (PS), detected at high concentration

227 EnDi-modified phosphatidylethanolamine (PE), phosphatidylserine (PS), phosphatidylcholine (PC), and s

228 nalysis showed that ScBOR1p co-isolates with phosphatidylserine (PS), phosphatidylcholine (PC), phosp

229 hatidic acid (PA), phosphoethanolamine (PE), phosphatidylserine (PS), phosphatidylglycerol (PG), phos

230 pecific eat-me signals, such as externalized phosphatidylserine (PS), that are recognized in a specif

231 establish that PlyCB interacts strongly with phosphatidylserine (PS), whereas its interaction with ot

232 of three peptides per vesicle, but only with phosphatidylserine (PS)-containing vesicles.

233 receptors known for their functional role in phosphatidylserine (PS)-dependent clearance of apoptotic

234 el process whereby large, intact, inside-out phosphatidylserine (PS)-exposed autophagic vesicles are

235 Binding of coagulation factors to phosphatidylserine (PS)-exposing procoagulant-activated

236 MDSs) to analyze how annexin-V (A5) binds to phosphatidylserine (PS)-rich membranes leading to high C

237 complexes (SLMO2-TRIAP1 in humans) serve as phosphatidylserine (PS)-specific lipid transfer proteins

238 cell surface exposure of the membrane lipid phosphatidylserine (PS).

239 immune antibodies against the membrane lipid phosphatidylserine (PS).

240 osphatidylinositol-bisphosphate (PIP(2)) and phosphatidylserine (PS).

241 interacting with cell- and virion-associated phosphatidylserine (PS).

242 karyotic membranes is the negatively charged phosphatidylserine (PS).

243 low basal activity, it is fully activated by phosphatidylserine (PS).

244 ibitory receptor TIM3 (hTIM3) and its ligand phosphatidylserine (PSF).

245 an occur with phosphatidylcholines (PCs) and phosphatidylserines (PSs), making them indistinguishable

246 s (PCs), phosphatidylethanolamine (PEs), and phosphatidylserines (PSs).

247 on of oncogenic K-Ras and H-Ras by depleting phosphatidylserine (PtdSer) and cholesterol contents, re

248 Phosphatidylserine (PtdSer) and phosphatidylinositol 4,5

249 o negatively charged membrane lipids (mainly phosphatidylserine (PtdSer) and phosphoinositides (PtdIn

250 luorescence imaging approaches revealed that phosphatidylserine (PtdSer) exposure on the outer leafle

251 Here, we show that phosphatidylserine (PtdSer) is exposed on the head regio

252 Phosphatidylserine (PtdSer) receptors that are responsib

253 Phagocytes express multiple phosphatidylserine (PtdSer) receptors that recognize apo

254 The plasma membrane is uniquely enriched in phosphatidylserine (PtdSer).

255 ll surface, the most fundamental of which is phosphatidylserine (PtdSer).

256 l immunoglobulin mucin receptor-4 (TIM-4), a phosphatidylserine receptor expressed on macrophages tha

257 We report that the phosphatidylserine receptor HAVCR1 (refs.

258 KIM-1/TIM-1 is a phosphatidylserine receptor that is expressed on epithel

259 The phosphatidylserine receptor TIM4, encoded by TIMD4, medi

260 lasmacytoid DCs (pDCs) that express the TIM1 phosphatidylserine receptor, a known viral- and exosomal

261 However, many phosphatidylserine receptors are also capable of recogni

262 xperiments to produce an atomistic model for phosphatidylserine recognition by the immune receptor Ti

263 isit the work on signaling downstream of the phosphatidylserine recognition receptor BAI1, and evalua

264 Phosphatidylserine recognition receptors are a highly di

265 On the oocyte, phosphatidylserine recognition receptors BAI1, CD36, Tim

266 We also propose the concept that phosphatidylserine recognition receptors could be viewed

267 Most of the phosphatidylserine recognition receptors dampen inflamma

268 Therefore, how phosphatidylserine recognition receptors mediate specifi

269 results establish that PSR-1 is a conserved, phosphatidylserine-recognizing phagocyte receptor.

270 step in osteoclastogenesis is controlled by phosphatidylserine-regulated activity of several protein

271 transfer activity for phosphatidic acid and phosphatidylserine, respectively.

272 binds to phosphatidylinositol phosphates and phosphatidylserine (restricted to the cell membrane inne

273 ce from the PM and impaired Ca(2+)-triggered phosphatidylserine scrambling.

274 er repels perforin and, in addition, exposed phosphatidylserine sequesters and inactivates perforin.

275 Anionic liposomes containing phosphatidylserine showed higher clearance to the lympha

276 trast, replacement with 1-palmitoyl-2-oleoyl-phosphatidylserine stimulated C1P transfer by ACD11 and

277 d provided strong discrimination against the phosphatidylserine substrate.

278 or of this lipid flippase, and specific to a phosphatidylserine substrate.

279 milar overall fold as phospholipase D (PLD), phosphatidylserine synthase (PSS) and tyrosyl-DNA phosph

280 the PAP-mediated regulation of CHO1-encoded phosphatidylserine synthase (PSS), which catalyzes the c

281 We report that compound 13, a novel phosphatidylserine-targeting zinc(II) dipicolylamine dru

282 Interestingly, at high proportions of phosphatidylserine, the Kd values of all four proteins b

283 e enzyme responsible for remodeling of human phosphatidylserine to bacterial phosphatidylethanolamine

284 lases (PSDs) catalyze the decarboxylation of phosphatidylserine to generate phosphatidylethanolamine,

285 e 1 (Psd1p), an ancient enzyme that converts phosphatidylserine to phosphatidylethanolamine in the in

286 eing required due to its ability to transfer phosphatidylserine to the TGN.

287 vely modifies cell surface determinants (eg, phosphatidylserine) to promote platelet phagocytosis by

288 mutagenesis, we found that ABCA1's PIP2 and phosphatidylserine translocase activities are independen

289 r drugs in cultured cell lines by monitoring phosphatidylserine translocation that occurs in early ap

290 osphatidylcholine, phosphatidylethanolamine, phosphatidylserine, triacylglycerol, and cholesteryl est

291 ltiple cell markers and largely externalized phosphatidylserine; vascular images illustrate MP biogen

292 In contrast, phosphatidylserine vesicles were only marginally affecte

293 simulations suggest that PR3 interacts with phosphatidylserine via a small number of amino acids, wh

294 The current transient seen with phosphatidylserine was abolished by the mutation E198Q,

295 lipids such as phosphatidylethanolamine and phosphatidylserine were only moderately increased, by fo

296 P and the negatively charged lipid substrate phosphatidylserine, whereas only a diminutive current wa

297 ecific binding of myristoylated recoverin to phosphatidylserine, whereas the extent of penetration of

298 Furthermore, we reveal that the phospholipid phosphatidylserine, which becomes exposed on the damaged

299 ls of intracellular phospholipids, including phosphatidylserine, which controlled AML stemness and di

300 These antibodies recognize phosphatidylserine, which is exposed on the surface of a